Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Exploratory analyses of factors related to 5-aminolevulinic acid-induced intraoperative hypotension during malignant glioma surgery via literature review","authors":"Kyoichi Tomoto ,&nbsp;Akihiko Teshigawara ,&nbsp;Tomohiro Aoki ,&nbsp;Masahiko Itani ,&nbsp;Yuzuru Hasegawa ,&nbsp;Yuichi Murayama ,&nbsp;Toshihide Tanaka","doi":"10.1016/j.pdpdt.2025.104675","DOIUrl":"10.1016/j.pdpdt.2025.104675","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic diagnosis using 5-aminolevulinic acid (5ALA) improves glioma resection but has been associated with intraoperative hypotension (IOH), particularly in Japan. Although nitric oxide (NO) production has been suggested as a mechanism, the pathophysiology remains unclear.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 148 glioma patients who underwent surgery between 2015 and 2024, comparing 5ALA(+) and 5ALA(-) groups in terms of IOH incidence and potential contributing factors, including age, body mass index, antihypertensive drug use, anesthesia duration, and extent of resection. IOH was defined as a mean arterial pressure &lt;60 mmHg after induction. We also assessed phosphorylation of endothelial NO synthase (eNOS) in surgical specimens using immunofluorescence.</div></div><div><h3>Results</h3><div>IOH occurred in 88.9 % of the 5ALA(+) group and 82.9 % of the 5ALA(-) group (<em>p</em> = 0.296). Elderly patients (&gt;60 years old) and those using angiotensin II receptor blockers (ARBs) showed significantly higher IOH incidence in the 5ALA(+) group. Immunofluorescence revealed no detectable phospho-eNOS expression in tumor tissues, regardless of IOH presence.</div></div><div><h3>Conclusions</h3><div>Our findings confirm previously reported risk factors for 5ALA-induced IOH, including older age and ARB use. The lack of eNOS expression in glioma tissues suggests that systemic, rather than tumoral, endothelial responses may mediate IOH via heme-dependent NO synthesis. Further studies using non-tumor tissues or experimental models are needed to elucidate the precise mechanisms and potential interactions between ARBs and 5ALA metabolism.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104675"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term postoperative changes in nucleus drop cases during phacoemulsification surgery: a comparative analysis of the choroidal vascular index following pars plana vitrectomy","authors":"Ali Hakim Reyhan ,&nbsp;Funda Yüksekyayla ,&nbsp;İrfan Uzun ,&nbsp;Çağrı Mutaf ,&nbsp;Mübeccel Bulut ,&nbsp;Ali Şimşek ,&nbsp;Mehmet Eryavuz","doi":"10.1016/j.pdpdt.2025.104676","DOIUrl":"10.1016/j.pdpdt.2025.104676","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the clinical outcomes of cases of nucleus drop developing during phacoemulsification surgery. It particularly focused on analyzing the effects of pars plana vitrectomy (PPV) on postoperative visual and anatomical parameters, including choroidal thickness and the choroidal vascular index (CVI).</div></div><div><h3>Methods</h3><div>Patients who experienced nucleus drop during phacoemulsification and subsequently underwent PPV were reviewed retrospectively. Data for these cases were compared with a group of patients who underwent uncomplicated phacoemulsification and with a healthy control group. Key parameters assessed included surgical outcomes and changes in choroidal metrics, including quantitative assessments of choroidal thickness in various regions and the CVI, measured using enhanced depth imaging optical coherence tomography.</div></div><div><h3>Results</h3><div>Mean visual acuity in the PPV eyes was 0.44±0.11, significantly lower than the 0.71±0.13 in the phacoemulsification group and 0.80±0.08 in the controls (p &lt; 0.001). Nasal choroidal thickness at 1000 µm was markedly lower in the PPV eyes (282.08±53.67 µm) compared with both the phacoemulsification (341.94±54.88 µm) and control (379.19±67.65 µm; p &lt; 0.001) groups, with similar significant decreases being observed across other choroidal thickness parameters. However, no significant intergroup differences were observed in terms of CVI or stromal area/luminal area (LA/SA) ratio values (p &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>The study findings demonstrated that decreases observed in choroidal thickness, total choroidal area, luminal area, and stromal area measurements indicate that this procedure affects the anatomical structure. However, the similarities in CVI and LA/SA ratio values suggest that the relative balance within the microvascular structure is maintained.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104676"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of choroidal vascular changes in juveniles with different degrees of myopia: The application of swept-source optical coherence tomography angiography","authors":"Linbo He ,&nbsp;Qing Wang ,&nbsp;Ziyang Li ,&nbsp;Libing Song ,&nbsp;Bo Liu ,&nbsp;Yuli Yang","doi":"10.1016/j.pdpdt.2025.104674","DOIUrl":"10.1016/j.pdpdt.2025.104674","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiological characteristics of myopic eyes further.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case-control study involving 103 patients (198 eyes) aged 6–17 years who had undergone SS-OCT examination. Based on equivalent spherical power, they were divided into four groups: emmetropia group, low myopia group, moderate myopia group, and high myopia group. The density of superficial capillary plexuses (SCP), choriocapillaris (CC), choroid vessel (CV)layers, and subfoveal choroidal thickness (SFCT) in the macular area were measured using SS-OCT. Multivariate regression analysis was employed to determine the ocular and demographic factors associated with retinal and choroidal blood flow indicators.</div></div><div><h3>Results</h3><div>In the temporal parafoveal area, the superficial capillary plexus (SCP) density was significantly lower in the moderate myopia group compared to the low myopia group (47.27 ± 2.21 vs. 48.51 ± 1.8, <em>p</em> = 0.002). Conversely, subfoveal choroidal vessel (CV) density was substantially higher in highly myopic eyes than in emmetropic eyes (56.98± 3.65 vs. 53.70 ± 4.31, <em>p</em> = 0.023). The multiple linear regression analysis showed that in the area under the fovea, thinner choroidal thickness is associated with higher choroidal vessel density. Specifically, as choroidal thickness decreases, the density of choroidal vessels increases (<em>p</em> = 0.024).</div></div><div><h3>Conclusions</h3><div>For juveniles, with the progression of myopia, the density of retinal superficial blood vessels and choroidal capillaries remains at a relatively stable level, while the choroidal vessel density under the fovea gradually increases. The main cause of changes in choroidal vessel density is the thickness of choroid under the fovea.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104674"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic chamber combined with photodynamic therapy inhibits bacterial growth on dental devices","authors":"Jeter Bochnia Ribeiro ,&nbsp;Augusto Alberto Foggiato ,&nbsp;Douglas Silva Fernandes ,&nbsp;João Victor Frazão Câmara ,&nbsp;Amanda de Oliveira Pinto Ribeiro ,&nbsp;Fabiana Mantovani Gomes França","doi":"10.1016/j.pdpdt.2025.104669","DOIUrl":"10.1016/j.pdpdt.2025.104669","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy is a two-stage treatment that combines light energy with a photosensitizer, and enhances the treatment against bacterial infections. In this context, the present study evaluated a newly patented device, called an ultrasonic photodynamic inactivation device (UPID), which performs microbial inactivation using photodynamic therapy for both prosthetic braces (PBs) and prototyped surgical guides (PSGs).</div></div><div><h3>Methods</h3><div>Photodynamic inactivation was analyzed by contaminating the instruments with bacterial suspensions (3 × 10⁸ CFU/mL) of 100 µM/L methylene blue solution for 20 min, followed by irradiation (0.30 J/cm²) with red light-emitting diode (660 nm) for 20 min, on three types of microorganisms: <em>Candida albicans</em> ATCC 10,231, <em>Staphylococcus aureus</em> ATCC 25,923 and <em>Escherichia coli</em> ATCC 25,922. The PSGs included a group with irradiation for 30 min (0.45 J/cm²), and a control group with 0.2 % peracetic acid, evaluated at both 20-minute time points. Microbial inhibition was assessed by counting the number of colony-forming units (CFU), and by the data evaluated using the Shapiro-Wilk, Mann-Whitney-U, and Kruskal-Wallis tests, at a 5 % significance level.</div></div><div><h3>Results</h3><div>All experimental treatments showed significant reduction in log CFU/mL. The UPID promoted a significant microbial reduction (<em>p</em> &lt; 0.001), compared with the positive control. In addition, peracetic acid was more effective than PDT for the PSG (<em>p</em> &lt; 0.001). However, after 20 min, both treatments protected the surface material against bacterial growth.</div></div><div><h3>Conclusion</h3><div>The device proved effective for microbial inhibition of PB and PSG, thus proposing a new technique for the non-toxic disinfection of biomedical devices.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104669"},"PeriodicalIF":3.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"InnovEyes photodiagnosis of corneal parameters and photoablation in LASIK: a review of literature","authors":"Yuen Tsing Adeline Ho ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104661","DOIUrl":"10.1016/j.pdpdt.2025.104661","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104661"},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of early inner retinal layer changes in hydroxychloroquine users without evident retinopathy: A comparative study","authors":"Mahmut Asfuroğlu ,&nbsp;Ahmet Selçuk Çobanoğlu ,&nbsp;Yonca Asfuroğlu ,&nbsp;Cenk Zeki Fikret ,&nbsp;Nil İrem Uçgun Zeki Fikret","doi":"10.1016/j.pdpdt.2025.104662","DOIUrl":"10.1016/j.pdpdt.2025.104662","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to examine alterations in the macular ganglion cell complex (GCC), peripapillary retinal nerve fiber layer (RNFL), and macular vasculature prior to the manifestation of evident outer retinal toxicity in patients receiving hydroxychloroquine (HCQ).</div></div><div><h3>Material-Method</h3><div>The present comparative cross-sectional study included 42 patients with no evident retinopathy who were taking &lt;5 mg/kg HCQ for rheumatoid arthritis and 41 age-matched healthy subjects. Both groups were analyzed using swept-source optical coherence tomography (SS-OCT), comprising macular GCC and peripapillary RNFL. Macular vessel density (MVD) analysis was conducted using OCT angiography.</div></div><div><h3>Results</h3><div>The superior (<em>p</em> = 0.04), inferior (<em>p</em> = 0.01), and total GCC (<em>p</em> = 0.02) values were significantly lower in the study group than in the control group. However, the RNFL and MVD measurements demonstrated no statistically significant disparities in any of the quadrants between the two groups (<em>p</em> &gt; 0.05). The subgroup analysis revealed that patients who had received HCQ for ≥ 8 years demonstrated significantly lower superior, inferior, and total GCC thickness, in addition to thinner RNFL values in superior quadrants when compared to patients who had received HCQ for a period of &lt; 8 years and the control group.</div></div><div><h3>Conclusion</h3><div>The present study demonstrated that after eight years of HCQ use at recommended doses, significant thinning of the inner retinal layers was observed in eyes exhibiting no evident retinal toxicity. It may be beneficial to include an inner retinal layer assessment in individuals chronically using HCQ as part of a comprehensive ophthalmic screening process.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104662"},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Antimicrobial Photodynamic Inactivation of Pseudomonas aeruginosa Persister Cells and Biofilms” [Photodiagnosis and Photodynamic Therapy 51 (2025) 104456]","authors":"Mona Mahmoud ,&nbsp;Peter Richter ,&nbsp;Philipp Arnold ,&nbsp;Michael Lebert ,&nbsp;Andreas Burkovski","doi":"10.1016/j.pdpdt.2025.104508","DOIUrl":"10.1016/j.pdpdt.2025.104508","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104508"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of retinal and choroidal microvascular changes after endonasal endoscopic pituitary adenoma resection: An OCTA study","authors":"Liu Chen ,&nbsp;Linhao Wang ,&nbsp;Yonggang Wu ,&nbsp;Ning Li ,&nbsp;Lin Lin ,&nbsp;Xiaolong Li ,&nbsp;Yunxian Gao ,&nbsp;Yong Zhao","doi":"10.1016/j.pdpdt.2025.104639","DOIUrl":"10.1016/j.pdpdt.2025.104639","url":null,"abstract":"<div><h3>Background</h3><div>This study used swept-source optical coherence tomography angiography (SS-OCTA) to compare retinal and choroidal vascular parameter changes before and after transsphenoidal surgery in pituitary adenoma (PA) patients, and to compare these changes with healthy controls, in order to evaluate its predictive value for visual recovery and determine the optimal timing for surgery.</div></div><div><h3>Methods</h3><div>23 PA patients (46 eyes) and 25 healthy volunteers (50 eyes) were included. The PA group was followed up at 1 week and 1 month postoperatively. Retinal and choroidal parameters in the macula(M) area and optic nerve head(ONH) area were assessed, including thickness(T), volume(V), vascular flow density (VFD), foveal avascular zone (FAZ), choroidal vascular volume (CVV) and choroidal vascular index (CVI).</div></div><div><h3>Results</h3><div>Comparison of retinal and choroidal morphology and blood flow between the case group and the control group showed significant increases in the deep capillary plexus (DCP) thickness and volume in the macula. The superficial capillary plexus (SCP) thickness, volume, large and medium choroidal vessels (LMCV) CVI (<em>p</em> = 0.032) in the optic disc area, as well as all indicators of the FAZ were significantly reduced. Compared to preoperative values, a week postoperatively, SCP-T and SCP-V in the optic disc area, and DCP FAZ perimeter all significantly decreased, while SCP VFD in the foveal avascular zone within 300 μm (FAZ300) significantly increased (<em>p</em> = 0.047). Compared to preoperative values, 1 month postoperatively, LMCV choroidal matrix density (CSI), CVI (<em>p</em> = 0.022) and DCP-T in the optic nerve area significantly decreased, while SCP-FAZ300 significantly increased (<em>p</em> = 0.0282). Tumor size was the most important factor affecting retinal and choroidal parameters.</div></div><div><h3>Conclusion</h3><div>The SCP-T, CSI, CVI, and other parameters in PA patients were significantly lower compared to healthy controls. These parameters further decreased after decompression surgery, likely due to secondary changes from optic nerve atrophy caused by tumor compression. The continulous improvement of SCP foveal avascular zone within 300 μm(FAZ300) may be related to the recovery of blood flow after the decompression, as the macular cells remain intact. These parameters—SCP-FAZ300, LMCV-CVI/CSI, and SCP-ONH T/V—collectively quantify postoperative visual acuity(VA)and visual field(VF) outcomes and guide surgical timing selection.These findings suggest that PA patients require earlier screening and treatment, and OCTA can serve as an optimal non-invasive evaluation tool.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104639"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Correlation of retinal curvature with ocular biometry in patients with myopia” [Photodiagnosis and Photodynamic Therapy 52 (2025) 104505]","authors":"Guo-Ren Xu ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2025.104605","DOIUrl":"10.1016/j.pdpdt.2025.104605","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104605"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “ALA-PDT promotes IL-1β secretion from human SZ95 sebocytes via activation of the NLRP3 inflammasome” [Photodiagnosis and Photodynamic Therapy 46 (2024) 104007]","authors":"Jian Zhang ,&nbsp;Yufeng Chang ,&nbsp;Suqing Liu ,&nbsp;Jiang Tuo ,&nbsp;Zhongyi Xu ,&nbsp;Jiayi Ying ,&nbsp;Yijian Zhu ,&nbsp;Zhengzhou Shi ,&nbsp;Christos C. Zouboulis ,&nbsp;Min Jiang ,&nbsp;Qianqian Wang ,&nbsp;Leihong Xiang","doi":"10.1016/j.pdpdt.2025.104607","DOIUrl":"10.1016/j.pdpdt.2025.104607","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104607"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}