Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins","authors":"Xiaoqing Wang ,&nbsp;Ting Zhang ,&nbsp;Tianhang Li ,&nbsp;Yahui Feng ,&nbsp;Li Ma ,&nbsp;Dongmei Li ,&nbsp;Yeqiang Song ,&nbsp;Dongmei Shi","doi":"10.1016/j.pdpdt.2025.104500","DOIUrl":"10.1016/j.pdpdt.2025.104500","url":null,"abstract":"<div><div>Periocular basal cell carcinoma (pBCC) is the most common malignancy in the periocular region, characterized by local aggressiveness, high incidence, and significant recurrence rates. While surgery is the primary treatment option, achieving complete lesion removal can be challenging due to the sensitive anatomy of this area and associated cosmetic considerations. Recent advancements in photodynamic therapy (PDT) have demonstrated promising efficacy and cosmetic outcomes for superficial BCC, offering alternatives to traditional treatments. However, PDT's effectiveness is often limited by the penetration depth of photosensitizers, particularly for deep tumors. To address these challenges, we developed a regimen that combines palliative surgery with immediate PDT for pBCC cases with inadequate or positive surgical margins. This integrated approach aims to overcome the penetration limitations of PDT while enhancing tumor clearance and preserving cosmetic outcomes. We report on three cases where all patients achieved complete clinical remission, with satisfactory cosmetic results and no recurrence observed during follow-up periods ranging from 12 to 23 months. Our findings suggest that palliative surgical resection, in conjunction with PDT, represents an effective treatment strategy for pBCC. This approach is particularly valuable when standard surgical margins cannot be achieved, especially considering the importance of cosmetic healing.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104500"},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of the macular and optic nerve head microvasculature in amblyopic and non-amblyopic patients with constant exotropia in comparison to healthy controls","authors":"Vahideh Manouchehri ,&nbsp;Amir Eftekhari Milani ,&nbsp;Raheleh Chegini ,&nbsp;Amin Arasteh","doi":"10.1016/j.pdpdt.2025.104506","DOIUrl":"10.1016/j.pdpdt.2025.104506","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the retinal microvascular changes in strabismic amblyopia and compare them to the strabismic cases without amblyopia and controls.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Participants</h3><div>Three groups of patients, including 25 amblyopic cases with exotropia (XT), 25 constant XT cases without amblyopia, and 25 healthy subjects as controls, are included in the study. Both eyes of the included participants are evaluated.</div></div><div><h3>Methods</h3><div>All the patients underwent a thorough ophthalmic examination, BCVA assessment, and macular and optic nerve head OCTA with the AngioVue™ Imaging System.</div></div><div><h3>Main Outcome Measures</h3><div>The vascular density (VD) of various layers (Deep and superficial capillary plexus (DCP and SCP) in different regions of the macula, optic nerve head, and FAZ area were evaluated as the target variables.</div></div><div><h3>Results</h3><div>42 females and 33 males with a mean age of 32.2 (95%CI:29.8-34.6) entered our study. The median exotropia in both groups was 35 PD. The parafoveal DCP VD was significantly lower in both eyes of amblyopic cases than in controls (53.56 and 52.31 vs. 56.13%, p:0.021, &lt;0.001). The parafoveal SCP VD was only lower in the dominant eye of the amblyopic cases than in the controls (50.53 vs. 53.54%, p:0.002). The foveal and peripapillary VD showed no significant difference between the groups. The FAZ area was significantly larger in amblyopic eyes than the fellow eyes (0.250 vs. 0.194 mm², p:0.025) and correlated with worse BCVA (Correlation Coefficient: 0.358, p: 0.011).</div></div><div><h3>Conclusions</h3><div>The amblyopia could be accompanied by a lower parafoveal DCP VD and a larger FAZ area in strabismic amblyopia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104506"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of repeated low-level red-light therapy on axial length, refraction, and macular retinal blood flow density in adolescents with mild to moderate myopia","authors":"Meifeng Ji ,&nbsp;Teer Ba ,&nbsp;Huixia Li ,&nbsp;Dongxue Wang ,&nbsp;Guisen Zhang ,&nbsp;Wei Wang","doi":"10.1016/j.pdpdt.2025.104499","DOIUrl":"10.1016/j.pdpdt.2025.104499","url":null,"abstract":"<div><h3>Background</h3><div>In order to evaluate the effectiveness of repeated low-level red-light (RLRL) therapy on stabilizing axial elongation and refractive changes in adolescents with mild to moderate myopia. In addition, we also examined whether RLRL therapy affects retinal blood flow density in the macular region, a factor previously unstudied in this context.</div></div><div><h3>Methods</h3><div>Conducted at a single clinical site, this retrospective, single-arm study followed participants over six months, with assessments at baseline, 1 month, 3 months, and 6 months. The primary outcomes included axial length and spherical equivalent refraction (SER) changes. Secondary assessments included retinal blood flow density (superficial and deep macular layers), white-to-white corneal diameter, central corneal thickness, intraocular pressure (IOP), corneal curvature, light sensitivity, and peripheral retinal thickness.</div></div><div><h3>Results</h3><div>There were 32 enrolled participants (mean age = 11.5 ± 1.72) in the current study. The spherical equivalent (SER) remained relatively stable over the first three months, but it significantly improved at six months, changing from -2.39 ± 2.21 D at baseline to -2.01 ± 2.12 D (<em>P</em> &lt; 0.05). However, the axial length also showed minimal variation across follow-up visits, indicating stable eye growth with no substantial elongation throughout the study period. Furthermore, RLRL therapy resulted in stable measurements across primary and secondary outcomes (all <em>P</em> &gt; 0.05), with no significant changes over the six months. There were no obvious side effects following the treatment.</div></div><div><h3>Conclusions</h3><div>Low-energy red light therapy shows promise as a non-invasive approach for stabilizing myopia in adolescents, with no observed compromise to retinal blood flow density. Further longitudinal research is needed to validate these findings and support clinical recommendations for myopia management.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104499"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report”","authors":"Manizhe Khosravi ,&nbsp;Salehoddin Bouya ,&nbsp;Masoud Keikha","doi":"10.1016/j.pdpdt.2025.104501","DOIUrl":"10.1016/j.pdpdt.2025.104501","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104501"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Fourier transform infrared spectroscopy and chemometric analysis to predict the bacilloscopic index in the saliva of leprosy patients","authors":"Paulo Cezar de Moraes ,&nbsp;Maria Lúcia Scroferneker ,&nbsp;Alessandra Koehler ,&nbsp;Letícia Maria Eidt ,&nbsp;Cristiane Almeida Soares Cattani ,&nbsp;Valeriano Antonio Corbellini","doi":"10.1016/j.pdpdt.2025.104507","DOIUrl":"10.1016/j.pdpdt.2025.104507","url":null,"abstract":"<div><div>Leprosy is an infectious disease caused by the <em>Mycobacterium leprae</em> complex. Although the diagnosis of this disease is clinical, additional tests are often needed. One of the most common tests is intradermal smear bacilloscopy, which detects the patient's bacillary load. However, bacilloscopy is an invasive test and its results are subjective. The aim of this study was to propose a methodology based on Fourier transform infrared (FTIR) spectroscopy to predict the bacilloscopic index in the saliva of leprosy patients. A total of 88 saliva samples were included, and the bacilloscopic index of the patients was previously defined by intradermal smear bacilloscopy. The saliva samples were analyzed by attenuated total reflection (ATR)-FTIR; a supervised analysis with partial least squares regression (PLS), after orthogonal signal correction (OSC), was used to predict the bacilloscopic index. The PLS model with three latent variables and one OSC component obtained a coefficient of determination greater than 0.9999 in both the calibration and prediction sets. The model was able to predict the bacilloscopic indexes with a minimum error, demonstrating its robustness. Thus, modeling with ATR/FTIR and multivariate calibration using one OSC component showed high accuracy and reproducibility, overcoming the limitations of intradermal smear bacilloscopy and proving to be a promising method in the clinical management of patients with leprosy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104507"},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations","authors":"Yugo Minegishi,&nbsp;Yasutomo Nomura","doi":"10.1016/j.pdpdt.2025.104498","DOIUrl":"10.1016/j.pdpdt.2025.104498","url":null,"abstract":"<div><h3>Introduction</h3><div>The successful diagnosis and treatment of early-stage breast cancer enhances the quality of life of patients. As a promising alternative to recently developed magnetic resonance imaging-guided radiotherapy, we proposed fluorescence molecular imaging-guided photodynamic therapy (FMI-guided PDT), which requires no expensive equipment. In the FMI simulations, ICG-C11 which has emission peaks at near-infrared wavelengths was used as the FMI agent. In the PDT simulation, Upconversion nanoparticles-Quantum dots-Rose bengal (UCQR) which was a PDT agent with upconversion capabilities was used.</div></div><div><h3>Methods</h3><div>The feasibility of breast cancer diagnosis and treatment using our proposed method is evaluated through Monte Carlo simulations of exact light transport through a realistic breast model in the prone position. Monte Carlo modeling in voxelized media was performed. Fluorescence propagation from the tumor and the amount of singlet oxygen produced within the tumor were estimated from the calculated fluence. Next, the effects of tumor diameter and depth from the skin surface on the simulation results were evaluated.</div></div><div><h3>Results</h3><div>The simulation results showed successful detection of tumors with diameters of 5–9 mm in the 15–25 mm depth region, where tumors are commonly found. Furthermore, simulations have estimated that those tumors can be completely treated by PDT with less than ten light irradiations.</div></div><div><h3>Conclusion</h3><div>This study suggests that fluorescent molecular imaging-guided photodynamic therapy may be a potential treatment for early-stage breast cancer. Our method would be more suitable than the conventional method for young women who are at higher risk of radiation exposure effects.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104498"},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative swept-source optical coherence tomography angiography (SS-OCTA) analysis of macular microvascular alterations in Bietti crystalline dystrophy","authors":"Shiyi Yin ,&nbsp;Jinyuan Wang ,&nbsp;Haihan Zhang ,&nbsp;Xuan Yang ,&nbsp;Jingting Luo ,&nbsp;Wenbin Wei","doi":"10.1016/j.pdpdt.2025.104485","DOIUrl":"10.1016/j.pdpdt.2025.104485","url":null,"abstract":"<div><h3>Purpose</h3><div>Bietti crystalline dystrophy (BCD) is a rare retinal dystrophy characterized by progressive visual impairment. This study aimed to evaluate changes in retinal and choroidal vessels and blood flow in BCD patients using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate potential parameters associated with visual function.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 eyes from 86 clinically diagnosed BCD patients, classified into three disease stages based on Yuzawa's classification. OCTA imaging (VG200S; SVision Imaging, Henan, China) covered a 12 mm × 12 mm area of the macula, measuring thickness, vessel density (VD), perfusion area (PA), choroidal vascularity index (CVI), choroidal vascularity volume (CVV), and foveal avascular zone (FAZ) metrics. Associations between OCTA parameters and visual function metrics, including best-corrected visual acuity (BCVA), mean deviation (MD) and visual field index (VFI) of the Humphrey visual field test, were analyzed.</div></div><div><h3>Results</h3><div>By stage 3, 92 % of eyes exhibited an undetectable ellipsoid zone (EZ). From stage 1 to stage 2, VD in all retinal layers decreased significantly (<em>P</em> &lt; 0.05), whereas differences between stages 2 and 3 were not statistically significant (<em>P</em> &gt; 0.05). The FAZ area and perimeter showed no significant difference across the three stages (<em>P</em> &gt; 0.05). Choroidal parameters, including PA, CVI, and CVV, progressively decreased across all stages (<em>P</em> &lt; 0.001). Multivariate regression analysis revealed that SVC-VD (<em>P</em> &lt; 0.001), SVC-PA (<em>P</em> &lt; 0.001) and choroid-PA (<em>P</em> = 0.030) were significantly associated with BCVA, while DVC-VD (<em>P</em> = 0.014), outer retinal thickness (<em>P</em> = 0.011), and CVI (<em>P</em> = 0.004) were significantly associated with visual field damage.</div></div><div><h3>Conclusions</h3><div>SS-OCTA effectively quantifies the progressive microvascular changes in the retina and choroid associated with BCD. Retinal vascular alterations are prominent in the early stages of the disease, whereas choroidal damage persists throughout its progression. OCTA parameters of the retina and choroid demonstrate varying degrees of correlation with visual function, underscoring their potential as biomarkers for monitoring disease progression and evaluating therapeutic efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104485"},"PeriodicalIF":3.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of macula ganglion cell analysis and retinal nerve fiber layer thickness in preperimetric glaucoma, early stage glaucoma and healthy individuals","authors":"Ozlem AKTAS  OZALTUN ,&nbsp;Ozlem GURBUZ  KOZ ,&nbsp;Ahmet Alper YARANGUMELI","doi":"10.1016/j.pdpdt.2025.104495","DOIUrl":"10.1016/j.pdpdt.2025.104495","url":null,"abstract":"<div><h3>Purpose</h3><div>In this study, it was planned to compare the macular ganglion cell analysis (GCA) and peripapillary retinal nerve fiber layer (pRNFL) of the patients with preperimetric glaucoma (PPG), early stage glaucoma (EG) and the control group.</div></div><div><h3>Methods</h3><div>This retrospective study included a total of 103 eyes: 38 from EG patients, 30 from PPG patients, and 35 from healthy individuals at Ankara Bilkent City Hospital Glaucoma Unit between January 2018 and September 2021. Eyes were categorized into control, PPG, and EG groups based on visual field (VF) classification. Topcon DRI Optical Coherence Tomography (OCT)-1, a Swept−Source OCT (SS-OCT), measured optic nerve head parameters, pRNFL, gangliyon cell inner plexiform layer (GCIPL), and ganglion cell complex (GCC) thickness. Glaucomatous defects were identified using also the SS-OCT SuperPixel map. Diagnostic efficacy of OCT parameters was assessed through area under the curve (AUC) values.</div></div><div><h3>Results</h3><div>All pRNFL and ganglion cell parameters in OCT showed significant differences between the control-PPG and control-EG groups (<em>p</em> &lt; 0.05). GCIPL, GCC, and pRNFL thicknesses in the PPG and EG groups were significantly lower than those in the control group (<em>p</em> &lt; 0.05). The mean pRNFL thickness emerged as the most valuable diagnostic parameter for distinguishing between the control and EG groups (<em>p</em> &lt; 0.05). In the wide-field SuperPixel map, the frequency of glaucomatous defect detection was higher in the EG group than in the PPG group (<em>p</em> &lt; 0.05). Mean pRNFL and mean GCIPL thicknesses exhibited the highest sensitivity and specificity for differentiating glaucoma groups from controls.</div></div><div><h3>Conclusion</h3><div>OCT parameters were not significantly superior to each other in control-PPG and control-EG. The evaluation of pRNFL and GCA together is still considered to be the most valid diagnostic method.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104495"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of photodynamic research in bladder cancer: Trends and future directions","authors":"Xi Xu ,&nbsp;Jinshan Xu ,&nbsp;Hongliang Gao ,&nbsp;Zhaoyang Sheng ,&nbsp;Yang Xu ,&nbsp;Shuxiong Zeng ,&nbsp;Guanghua Chen ,&nbsp;Zhensheng Zhang","doi":"10.1016/j.pdpdt.2025.104494","DOIUrl":"10.1016/j.pdpdt.2025.104494","url":null,"abstract":"<div><h3>Background</h3><div>Recent years have seen the use of photodynamic technologies concerning the detection and therapy of bladder cancer (BC) due to their rapid development and well-established therapeutic impact. However, a thorough analysis and bibliometric assessment of photodynamic technologies publishing trends in BC has not been completed yet.</div></div><div><h3>Methods</h3><div>Retrieving bibliographies from the Web of Science Core Collection limited the publication date to December 31, 2023, from January 1, 2004. We used VOSviewer (Version 1.6.19) and CiteSpace (Version 6.4 R1) for both statistical and visualization analysis.</div></div><div><h3>Results</h3><div>We selected a total of 870 documents for analysis. The yearly publication findings show notable upward patterns over the last two decades. The Kochi Medical School in Japan was the most productive school, while the USA was the most productive nation. Japanese researcher Inoue Keiji published the highest number of photodynamic -related articles in BC. The most quoted and prolific journals were the <em>Photodynamic Therapy and Photodiagnosis</em>. According to the keyword analysis, the terms \"cystoscopy,\" \"carcinoma in situ,\" \"drug delivery,\" \"follow-up,\" \"hexaminolevulinate,\" and \"impact\" are all relatively recent and hot field.</div></div><div><h3>Conclusions</h3><div>Our investigation produced a bibliometric outcome for the field, potentially opening up new research opportunities. We suggest that future research concentrate on in-situ carcinoma identification, photosensitizer invention, medication delivery enhancement, and photodynamic technology follow-up in BC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104494"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of photodynamic therapy and LEEP in women of reproductive age with cervical squamous intraepithelial neoplasia 2 (CIN2): A prospective observational study in China","authors":"Cheng Li,&nbsp;Xuanhui Wang,&nbsp;Qiulin Cui,&nbsp;Mian He,&nbsp;Ming Chen","doi":"10.1016/j.pdpdt.2025.104496","DOIUrl":"10.1016/j.pdpdt.2025.104496","url":null,"abstract":"<div><h3>Background</h3><div>Non-invasive treatments, such as 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT), has gained increasing attention among women with cervical intraepithelial neoplasia grade 2 (CIN2) who have fertility requirements. To compare the effectiveness of 5-ALA-PDT and loop electrosurgical excision procedure (LEEP) in patients with CIN2, we conducted this prospective cohort study in Chinese patients with CIN2.</div></div><div><h3>Methods</h3><div>229 patients with CIN2 were enrolled. They were divided into the PDT Group (n=94) and LEEP Group (n=135) according to the patient's willingness. Patients were evaluated at the 3-, 6-, 12- and 18-month follow-up periods, using cytology, HPV testing, and colposcopy examination.</div></div><div><h3>Results</h3><div>At the 3-month follow-up, the rates of disease regression to normal or CIN1 in the PDT group were 76.6% (72/94) and 13.8% (13/94), respectively, whereas in the LEEP group, they were 80.7% (109/135) and 11.1% (15/135), respectively. Logistic regression analysis revealed that the transformation zone type 3 was the only risk factor for both the PDT (OR=3.68; 95% CI, 2.43-5.26; P=0.008) and LEEP groups (OR=2.34; 95% CI, 1.84-4.53; P=0.02). The treatment efficacy in the PDT group increased gradually and peaked at the 18-month follow-up point with disease disappearance and regression rates of 90.4% and 8.5%, respectively. The disease disappearance and regression rates in the LEEP group were highest at the first half year posttreatment, with disease disappearance and regression rates of 87.4% and 12.6%, respectively. The hrHPV-negative rates in the PDT group and LEEP group were the highest at the 18-month follow-up (78.7% and 74.8%). There was no significant difference in the disappearance or regression rates between the two groups at the follow-up points (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Our study revealed that both 5-ALA PDT therapy and LEEP were highly effective at treating CIN2. 5-ALA-PDT, as a non-invasive treatment, could be an effective option for CIN2 patients with fertility preservation needs.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104496"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}