Photodiagnosis and Photodynamic Therapy最新文献

{"title":"A chlorin e6 derivative-mediated photodynamic therapy for mild to moderate acne: A prospective, single-blind, randomized, split-face controlled study","authors":"Haiyan Zhang ,&nbsp;Yan Zhao ,&nbsp;Hui Tao ,&nbsp;Chunmei Feng ,&nbsp;Peiru Wang ,&nbsp;Linglin Zhang ,&nbsp;Xiaojing Liu ,&nbsp;Yamei Chen ,&nbsp;Xiuli Wang","doi":"10.1016/j.pdpdt.2024.104304","DOIUrl":"10.1016/j.pdpdt.2024.104304","url":null,"abstract":"<div><h3>Background</h3><p>Acne vulgaris is a chronic inflammatory skin disease involving the pilosebaceous unit.</p></div><div><h3>Objective</h3><p>To assess the efficacy and safety of a chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) in the treatment of mild to moderate acne patients.</p></div><div><h3>Methods</h3><p>In this prospective patient single-blind randomized split-face controlled study, patients diagnosed with mild to moderate acne were treated with four sessions of STBF-PDT on one-half of the face, while the other half were treated with the same dose of red-light treatment without photosensitizer. Follow-up assessment including the skin lesion clearance rate, facial fluorescence scattering spots on VISIA Porphyrins mode, and skin physiological parameters was conducted before and after treatment as well as 2 and 4 weeks after the final treatment.</p></div><div><h3>Results</h3><p>A total of 26 patients were recruited, of which 22 patients completed this study. STBF-PDT is significantly effective in improving lesions in patients with acne. The clearance rate of total lesions was 67.42±8.51 % in the STBF-PDT group and 41.05±11.97 % in the control group 4 weeks after the treatment (<em>P</em> &lt; 0.001). The average clearance rate of inflammatory lesions was 84.41±7.13 % in the STBF-PDT group and 50.10±13.91 % in the control group, with a statistically significance (<em>P</em> &lt; 0.0001). The skin sebum of the STBF-PDT side was significantly lower than that on the control side. There was no obvious adverse reaction especially no pain or reactive acne.</p></div><div><h3>Conclusion</h3><p>STBF-PDT may be a safe and effective treatment for mild to moderate acne and can significantly inhibit sebum secretion.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104304"},"PeriodicalIF":3.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003417/pdfft?md5=34d4328921699bbfd8a4eff4bc90d5f7&pid=1-s2.0-S1572100024003417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of choroidal parameters in type 1 macular neovascularization linked to central serous chorioretinopathy and neovascular age-related macular degeneration","authors":"Xiang-Gui Zhang ,&nbsp;Ming Yan ,&nbsp;Zhen Huang ,&nbsp;Ya Ye ,&nbsp;Zhen-De Deng ,&nbsp;Yan-Ping Song","doi":"10.1016/j.pdpdt.2024.104324","DOIUrl":"10.1016/j.pdpdt.2024.104324","url":null,"abstract":"<div><h3>Objective</h3><p>To use ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) to evaluate the choroidal features of neovascular age-related macular degeneration (nAMD) and type 1 macular neovascularization (MNV) attributable to central serous chorioretinopathy (CSC).</p></div><div><h3>Method</h3><p>A cross-sectional research was carried out to examine patients with type 1 MNV due to CSC (50 eyes) and nAMD (98 eyes) utilizing UWF SS-OCTA examinations. The scan procedure covered a vertical 20 mm × horizontal 24 mm region with 9 subfields. A typical set of 68 healthy eyes was used for comparison. The effects of different diagnoses on choroidal parameters were assessed using covariance tests, using gender and age as variables.</p></div><div><h3>Results</h3><p>The research showed that all choroidal characteristics were age-related (all <em>p</em> &lt; 0.05). The calculated marginal averages of choroidal thickness (ChT) and choroidal volume (CV) in the central area were substantially lower in the nAMD group than in the CSC group and the normal group after age differences were taken into account (all <em>p &lt;</em> 0.05). In both the superotemporal and temporal areas, the CSC group had a greater choroidal vascular index (CVI) compared to the nAMD group (<em>p &lt;</em> 0.05). Additionally, the CSC group had a greater temporal area choriocapillaris density (CCD) than the nAMD group (<em>p &lt;</em> 0.05).</p></div><div><h3>Conclusion</h3><p>At the choroidal level, type 1 MNV due to CSC and nAMD may be distinguished by UWF SS-OCTA. Compared to the nAMD affected eyes, the CSC affected eyes had increased ChT, CV, CVI, and CCD in several areas. The two diseases could be distinguished based on ChT and CV.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104324"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003612/pdfft?md5=130c73506c68ca4425a262d907ab9a63&pid=1-s2.0-S1572100024003612-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two laser power levels in the subthreshold micropulse yellow laser treatment of acute central serous chorioretinopathy","authors":"Liru Qin ,&nbsp;Daming Li ,&nbsp;Yuzhe Zhou ,&nbsp;Han Zhang ,&nbsp;Guisen Zhang ,&nbsp;Xiurong Zhang ,&nbsp;Wei Shi","doi":"10.1016/j.pdpdt.2024.104323","DOIUrl":"10.1016/j.pdpdt.2024.104323","url":null,"abstract":"<div><h3>Aims</h3><p>To compare the efficacy of two power levels in the 577 nm sub-threshold micro pulse laser (SML) treatment of acute central serous chorioretinopathy (aCSC).</p></div><div><h3>Methods</h3><p>A retrospective comparative study was conducted. A total of 65 patients (65 eyes) with aCSC were enrolled. Of which, 32 patients received low power treatment and 33 patients received high power treatment of 577 nm SML. Best-corrected visual acuity (BCVA), central macular thickness (CMT), fundus-monitored microperimetry and height of subfoveal choroidal thickness (SFCT) as well as subretinal fluid (SRF) were evaluated at baseline and 3 months.</p></div><div><h3>Results</h3><p>The height of SFCT and retinal sensitivity in the low power treatment group was significantly better than that in the high power treatment group at 4 weeks (all <em>p</em> &lt; 0.001). Mean BCVA improved from baseline to 3 months after treatments but with no significant difference between the two groups after 3 months (<em>p</em> &gt; 0.05). In the low power group, the CMT decreased from 379.76 ± 139.23 μm at baseline to 176.56 ± 37.78 μm at 3 months, and in the high power group, the CMT decreased from 364.97 ± 143.08 at baseline to 191.77 ± 38.26 μm at 3 months. There was no significant difference at 3 months between the two groups (<em>p</em> &gt; 0.05). Similar results were also found in term of SRF.</p></div><div><h3>Conclusions</h3><p>Timely intervention with 577 nm SML with low power treatment can improve visual acuity, and included anatomic success without adverse events.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104323"},"PeriodicalIF":3.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003600/pdfft?md5=267bc768dfa2d73e4c37941c1c94ad7a&pid=1-s2.0-S1572100024003600-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of photodynamic therapy as a minimally invasive treatment for oral verrucous carcinoma","authors":"Chen Li ,&nbsp;Dandan Wang ,&nbsp;Jian Ding","doi":"10.1016/j.pdpdt.2024.104320","DOIUrl":"10.1016/j.pdpdt.2024.104320","url":null,"abstract":"<div><div>Oral verrucous carcinoma (OVC) and proliferative verrucous leukoplakia (PVL) share similar histological characteristics and may have a common origin. When they appear simultaneously, the risk of malignant transformation in PVL increases. In elderly patients with both conditions, a safe, effective, simple, and minimally invasive treatment is preferable. Photodynamic therapy (PDT), a non-invasive treatment, utilizes specific wavelengths of light to activate photosensitizers, generating reactive oxygen species that selectively target malignant tissues with cytotoxic effects. This case report describes an elderly patient with coexisting extensive leukoplakia, PVL, and OVC, who achieved complete remission with no recurrence at 10 months following PDT. The treatment resulted in a satisfactory clinical outcome, preserving both the appearance and function of the oral cavity.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104320"},"PeriodicalIF":3.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003570/pdfft?md5=61a0262c1858112201062585c01ae3f7&pid=1-s2.0-S1572100024003570-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematoporphyrin photodynamic therapy for treatment of pathological scar with ulceration: A case report","authors":"Lianheng Xia ,&nbsp;Hang Lv ,&nbsp;Shaolei Yu ,&nbsp;Xiaoqing Xiang ,&nbsp;Yanliang Li ,&nbsp;Jiaxin Wang ,&nbsp;Guozhang Ma ,&nbsp;Jie Gao","doi":"10.1016/j.pdpdt.2024.104315","DOIUrl":"10.1016/j.pdpdt.2024.104315","url":null,"abstract":"<div><p>Pathological scars result from abnormal wound healing and represent a fibrotic process in the repair of skin injuries. Post-burn scars are prone to malignant transformation, especially when ulceration occurs, raising concerns for precancerous lesions. We report a case of a 56-year-old female with a 50-year history of a large burn scar on her left forearm. The scar developed non-healing ulceration with local pain and itching over the past three years. Treatment with hematoporphyrin photodynamic therapy (HpD-PDT) led to resolution of the ulceration, thinning of the scar tissue, and significant alleviation of pain and itching. After a five-year follow-up, there has been no recurrence of ulceration, suggesting that photodynamic therapy effectively promotes wound healing in scarred tissue with ulcerations.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104315"},"PeriodicalIF":3.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003521/pdfft?md5=071ce2556f9aed2b74440fd68aefcbe1&pid=1-s2.0-S1572100024003521-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the length of macular Bruch's membrane on fundus photograph and myopia occurrence in pre-myopia children aged 3–6 years: A 3-year longitudinal study","authors":"Xuejing Mi ,&nbsp;Yuxin Fang ,&nbsp;Jianing Pu ,&nbsp;Wei Chen ,&nbsp;Zhen Zhou ,&nbsp;Mengmeng Qin ,&nbsp;Ranran Zhang ,&nbsp;Dan Wang ,&nbsp;Yanyan Yang ,&nbsp;Chuzhi Peng ,&nbsp;Shimeng Bian ,&nbsp;Mingrui Jin ,&nbsp;Huaying Xu ,&nbsp;Yonghong Jiao","doi":"10.1016/j.pdpdt.2024.104322","DOIUrl":"10.1016/j.pdpdt.2024.104322","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the occurrence and influencing factors of myopia occurrence in pre-myopia children aged 3–6 years.</p></div><div><h3>Methods</h3><p>This study included 204 pre-myopia (-0.50D&lt;spherical equivalent (SE) ≤+0.75D) children with three years follow-up in Beijing Hyperopia Reserve Research. All participants underwent a comprehensive eye examination. The length of macular Bruch's membrane (BM) and the temporal vascular arcade angle were measured upon fundus photographs.</p></div><div><h3>Results</h3><p>Mean age at initial visit was 4.28 ± 0.98 years and mean SE was 0.45 ± 0.29D. Both at baseline and after 3 years of follow-up, axial length was longer in boys than that in girls. (all <em>P</em> &lt; 0.001) Children were divided into two groups according to the refractive status of children at the final follow-up: Myopia group (SE≤-0.50D) and Non-myopia group (SE&gt;-0.50D). The length of macular BM was shorter in Myopia group than that in Non-myopia group (<em>P</em> &lt; 0.001). Baseline SE and the length of macular BM were independent influencing factors which associated with myopia occurrence (OR, 0.031; 95 % CI, 0.008–0.117, <em>P</em> &lt; 0.001 and OR, 0.204; 95 % CI, 0.055–0.763, <em>P</em> = 0.018, respectively) by multivariate binary logistic regression analysis. SE changing process represented the changes of SE, Myopia group had bigger SE changes (<em>P</em> &lt; 0.001). And in the multivariate liner regression analysis, age was the common influencing factor of SE changing process in total participants, Non-myopia group and Myopia group (<em>B</em> = 0.234, <em>P</em> &lt; 0.001; <em>B</em> = 0.078, <em>P</em> = 0.010; <em>B</em> = 0.161, <em>P</em> = 0.046, respectively)</p></div><div><h3>Conclusions</h3><p>Initial SE and the length of macular BM in pre-myopia children aged 3–6 years were the independent factors of the occurrence of myopia. And initial age was the common factor that associated with SE changing process.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104322"},"PeriodicalIF":3.1,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003594/pdfft?md5=fca771f403031cc9d6386732ebb7f071&pid=1-s2.0-S1572100024003594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy combined with voriconazole of extensive ulcer caused by Trichosporon asahii","authors":"Shuting Chen ,&nbsp;Yuwu Luo ,&nbsp;Hui Wu ,&nbsp;Jing Zhang ,&nbsp;Wei Li","doi":"10.1016/j.pdpdt.2024.104313","DOIUrl":"10.1016/j.pdpdt.2024.104313","url":null,"abstract":"<div><p>Trichosporon species are part of the normal microbiota of humans which can cause both superficial and invasive infections, primarily affecting immunocompetent and immunocompromised hosts, respectively. Giant ulcer caused by Trichosporon asahii is relatively uncommon in immunocompetent hosts. Increased drug resistance and biofilm-associated virulence makes the treatment of infectious ulcers challenging. Herein, we present a case of a massive ulcer caused by T. asahii which resulted in completed healing when treated with photodynamic therapy (PDT) and voriconazole. It provided the feasibility for PDT combined with antifungal drugs to treat similar refractory cases.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104313"},"PeriodicalIF":3.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003508/pdfft?md5=c932e5b638564474d5e5bfb95f848bfb&pid=1-s2.0-S1572100024003508-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the comment on \"Hyperplasia of the retinal pigment epithelium secondary to subthreshold laser treatment in chronic central serous chorioretinopathy\"","authors":"Jacobo Emilio Enríquez-Fuentes ,&nbsp;Antonio Domingo Alarcón-García ,&nbsp;Carlos Oribio-Quinto ,&nbsp;José Ignacio Fernández-Vigo","doi":"10.1016/j.pdpdt.2024.104321","DOIUrl":"10.1016/j.pdpdt.2024.104321","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104321"},"PeriodicalIF":3.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003582/pdfft?md5=cb40924df52f11d8b3576c302feaa970&pid=1-s2.0-S1572100024003582-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified experimental adhesive with sepiolite nanoparticles on caries dentin treated with femtosecond laser and photodynamic activated erythrosine. An in vitro study","authors":"Fayez Hussain Niazi ,&nbsp;Badi Alotaibi ,&nbsp;Anshad M. Abdulla ,&nbsp;Sarah AbdulRahman AlTowayan ,&nbsp;Syed Zubairuddin Ahmed ,&nbsp;Dhaifallah Alshehri ,&nbsp;Abdulaziz Samran ,&nbsp;Nouf Alsuwayyigh ,&nbsp;Norhayati Luddin","doi":"10.1016/j.pdpdt.2024.104306","DOIUrl":"10.1016/j.pdpdt.2024.104306","url":null,"abstract":"<div><h3>Aim</h3><p>To assess the effect of CAD surface conditioners and their effect on Ra and SBS of tooth-colored filling material adhered to CAD surface with adhesive modified with 1 % Sep-NPs. Also, the DC of modified EA and its effect on the rheological properties.</p></div><div><h3>Methods</h3><p>Ninety human molars with carious extension up to the middle third of occlusal dentin were included. The teeth were then arbitrarily allocated into three groups based on the type of surface conditioning received (<em>n</em> = 30) Group 1 (PA), Group 2 (FS laser), and Group 3 (Ery PS). Ten samples from each group underwent Ra analysis using a stylus profiler. Twenty samples from each cohort were distributed into two subcategories based on the application of unmodified EA (A) and Sep-infiltrated EA (B). Composite restoration was built followed by SBS and failure mode analysis. Scanning electron microscopy and Energy dispersive X-ray EDX were assessed of sepiolite NPs. Degree of conversion (DC) and rheological analysis of the modified adhesive and unmodified adhesive were also performed. One-way analysis of variance (ANOVA) and the Tukey post hoc test were employed to conduct comparisons between the different groups.</p></div><div><h3>Results</h3><p>The highest score of Ra and bond strength were displayed by Group 1B (PA + Sep-NPs filled EA) (17.32 ± 1.43 MPa) samples. Nevertheless, the lowest values were established by Group 3A (Ery-PS + EA) (13.45 ± 0.80 MPa) treated teeth. An increase in Ra resulted in a rise in SBS.DC decreased with the incorporation of 1 % Sep-NPs in EA compared to unmodified EA.</p></div><div><h3>Conclusion</h3><p>Conditioning of CAD with PA and FS laser shows high surface roughness and favorable adhesion to experimental adhesive modified with 1 % Sep-NPs. Modified adhesive with 1 % Sep-NPs decreases DC and rheological properties.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104306"},"PeriodicalIF":3.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003430/pdfft?md5=ce15ba55482abbccc2a321c5ec954a01&pid=1-s2.0-S1572100024003430-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan nanoparticles, Rose Bengal-chitosan activated photodynamic therapy as final irrigant on pushout bond strength, smear layer removal efficacy and antibacterial effectiveness against E.faecalis","authors":"Fahad Alkhudhairy ,&nbsp;Mohammad H. AlRefeai","doi":"10.1016/j.pdpdt.2024.104316","DOIUrl":"10.1016/j.pdpdt.2024.104316","url":null,"abstract":"<div><h3>Aim</h3><p>Impact of final root canal disinfectants diode laser (DL), Rose Bengal photosensitizer (RBP), Chitosan Nanoparticles (CNPs), and CNPs modified RBP on Enterococcus faecalis (<em>E.faecalis</em>) survival rate, smear layer (SL) removal efficacy and push out bond strength (PBS) of resin sealer to the radicular dentin.</p></div><div><h3>Material and method</h3><p>Single rooted seventy-five human mandibular premolar teeth were sectioned at a level of cementoenamel (CEJ) and root canal treatment was performed using a ProTaper rotary instrument. To assess the antibacterial efficiency <em>E.faecalis</em> inoculation was performed using a pour plate method. The samples were arbitrarily allocated into five groups based on the final disinfectant received (<em>n</em> = 15) Group-1 (NaOCl+17 % EDTA), Group-2 (NaOCl+DL), Group-3 (NaOCl+CNPs), Group-4 (NaOCl+RBP activated by DL) and Group-5 (NaOCl+CNPs-RBP activated by DL). SEM analysis for SL removal was performed on five specimens from each group. Root canal obturation and sectioning were performed at cervical, middle, and apical levels. PBS and failure mode were analyzed using a universal testing machine (UTM) and stereomicroscope respectively. The data was subjected to analysis using one-way analysis of variance (ANOVA) and Tukey's post hoc test.</p></div><div><h3>Result</h3><p>Group 1 (NaOCl+17 % EDTA) (0.36 ± 0.01 CFU/mL) unveiled the maximum survival rate of tested bacteria. However, Group 5 (NaOCl+CNPs-RBP activated by DL) (0.11 ± 0.01 CFU/mL) displayed minimum survival of <em>E.faecalis</em>. The highest SL removal (1.44 ± 0.11) and bond integrity scores (12.23 ± 0.24 MPa) were recorded in the coronal section of Group 5 (NaOCl+ CNPs-RBP activated by DL) treated roots. However, the lowest removal of SL (3.15 ± 1.09) and PBS (7.24 ± 0.09 MPa) were recorded in Group 4 (NaOCl+RBP activated by DL) treated canals.</p></div><div><h3>CONCLUSION</h3><p>CNPs-RBP activated by DL as the final irrigant provided satisfactory antibacterial activity, SL removal, and bond strength outcomes compared to other tested groups.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104316"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003533/pdfft?md5=02a41ed6550773a9d7d03379ad820fb9&pid=1-s2.0-S1572100024003533-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}