Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Visualization of retinal displacement after macular hole surgery and its correlation with postoperative visual function","authors":"Naxin Duan ,&nbsp;Lin Liu ,&nbsp;Song Lin,&nbsp;Zetong Nie,&nbsp;Siqiong Bai,&nbsp;Boshi Liu,&nbsp;Xiaorong Li,&nbsp;Wenbo Li ,&nbsp;Bojie Hu","doi":"10.1016/j.pdpdt.2025.104503","DOIUrl":"10.1016/j.pdpdt.2025.104503","url":null,"abstract":"<div><h3>Purpose</h3><div>To observe retinal displacement following macular hole surgery using a three-dimensional barycenter localization algorithm and to evaluate its relationship with postoperative visual function.</div></div><div><h3>Methods</h3><div>This prospective study included 28 eyes of 27 patients with idiopathic macular holes. A customized algorithm takes a weighted sum to locate the perimacular area (PMA) barycenter based on the magnitude of the distance between the barycenter and the intersection of retinal vessels. Retinal displacement distance, angle, and the rate of change in the PMA were calculated by comparing the barycenters in preoperative and postoperative photographs. Correlations between retinal displacement and various clinical parameters were also analyzed.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcomes included retinal displacement characteristics (distance, angle, and rate of change in the PMA). Secondary outcomes were postoperative visual function, including best-corrected visual acuity, mean retinal sensitivity, and fixation stability.</div></div><div><h3>Results</h3><div>A significant \"rebound\" phenomenon, characterized by PMA wrinkling and extension, was observed in 11 cases (39.3 %). The PMA was lower at 1 month postoperatively compared to that preoperatively (<em>t</em> = 1.876, <em>p</em> = 0.025). The mean displacement distance at 1 and 3 months postoperatively was 7.725 ± 0.097 and 6.187 ± 0.827, respectively. Mean retinal sensitivity at 3 months postoperatively improved compared to preoperative values (<em>t</em> = -2.171, <em>p</em> = 0.039) and was significantly correlated with the rate of change in PMA at 3 months postoperatively (<em>t</em> = -2.162, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The three-dimensional barycenter localization algorithm effectively visualized retinal displacement. The PMA was shown to be associated with postoperative visual function in this analysis. The change trend of PMA and mean retinal sensitivity is consistent.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104503"},"PeriodicalIF":3.1,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study","authors":"Shuhei Suzuki ,&nbsp;Yoshiyuki Nagumo ,&nbsp;Kosuke Kojo ,&nbsp;Atsushi Ikeda ,&nbsp;Bunpei Isoda ,&nbsp;Akane Yamaguchi ,&nbsp;Kozaburo Tanuma ,&nbsp;Satoshi Nitta ,&nbsp;Masanobu Shiga ,&nbsp;Takashi Kawahara ,&nbsp;Shuya Kandori ,&nbsp;Akio Hoshi ,&nbsp;Hiromitsu Negoro ,&nbsp;Bryan J. Mathis ,&nbsp;Hiroyuki Nishiyama","doi":"10.1016/j.pdpdt.2024.104429","DOIUrl":"10.1016/j.pdpdt.2024.104429","url":null,"abstract":"<div><h3>Background</h3><div>To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience.</div></div><div><h3>Methods</h3><div>Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral resection of bladder tumors (TURBT) with orally 5-amibolevulinic acid at our institute. Surgical experience was categorized by urological experience (first-year and second-year) and PDD experience (&lt;10, 10–19, and ≥20 cases). Sensitivity, specificity, and accuracy rates were calculated based on PDD or white light (WL) findings and pathologic diagnosis. The bladder neck, trigone, and prostatic urethra were defined as areas with a high probability of tangential effect.</div></div><div><h3>Results</h3><div>A total of 108 patients and 343 specimens were extracted. The second-year surgeons had significantly higher accuracy rates than first-year surgeons (81.5 % vs. 69.0 %, <em>p</em> = 0.013), while PDD experience did not significantly affect accuracy rates (76.5, 75.5, and 69.0 %). In addition, the accuracy rate was also significantly lower in tangential effect areas (59.6 % vs. 80.8 %). Multivariate analysis identified urological experience as a significant factor improving accuracy rate (odds ratio [OR] 2.14) while tangential effects substantially reduced accuracy rate (OR 0.37). Notably, combining both PDD and WL resulted in a sensitivity exceeding 94 %, even in first-year urology residents and tangential effect areas.</div></div><div><h3>Conclusions</h3><div>Urological experience had a greater impact on diagnostic performance of PDD compared to PDD experience. The combination of PDD and WL findings may improve sensitivity and reduce the possibility of missed diagnoses for less experienced urology residents.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104429"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts","authors":"Jiaoquan Chen ,&nbsp;Xinyi Xie ,&nbsp;Yingxue Liu,&nbsp;Fengyi Chen,&nbsp;Yeqing Gong,&nbsp;Bihua Liang,&nbsp;Yiling Wu,&nbsp;Shiqi He,&nbsp;Yueming Li,&nbsp;Huilan Zhu,&nbsp;Shaoyin Ma","doi":"10.1016/j.pdpdt.2024.104407","DOIUrl":"10.1016/j.pdpdt.2024.104407","url":null,"abstract":"<div><h3>Significance</h3><div>Plantar warts, benign lesions on the soles of the feet, are caused by the human papillomavirus (HPV) infecting keratinocytes. Complete eradication of these warts is challenging, often leading to recurrences. This study evaluates the combined clinical efficacy of topical 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) and fractional carbon dioxide (CO₂) laser treatment for recalcitrant plantar warts.</div></div><div><h3>Approach</h3><div>Data from 10 patients with recalcitrant plantar warts were analyzed. Initially, thickened hyperkeratotic tissue was removed using a super-pulsed CO₂ laser. This was followed by fractional laser application, after which a 20 % 5-ALA cream was applied occlusively for 4 h. Patients then received He-Ne laser irradiation for 30 min at an energy density of 100 mW/cm², with treatments spaced 4 weeks apart.</div></div><div><h3>Results</h3><div>The study included 10 participants aged 24 to 53 years (mean age: 33.4 ± 8.09 years). In total, 40 lesions were treated across 1 to 9 PDT sessions, with an average of 5.2 ± 2.86 sessions per patient. Complete clearance was achieved in 3 patients (30 %), 4 patients (40 %) showed an excellent response (≥80 % improvement), while 2 patients had a partial response. One patient (10 %) showed &lt;50 % improvement. The overall clearance rate was 70 % (28 out of 40 lesions). Aside from temporary pain during the procedure and mild erythema post-treatment, one patient developed localized proliferative scarring. After a one-year follow-up, only one patient experienced recurrence.</div></div><div><h3>Conclusions</h3><div>The combination of 5-ALA PDT and fractional CO₂ laser therapy shows promise as an effective and safe alternative for treating persistent plantar warts.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104407"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The disinfectant effects of portable ultraviolet light devices and their application to dentures","authors":"Kae Harada ,&nbsp;Reiya Horinouchi ,&nbsp;Mamoru Murakami ,&nbsp;Masakazu Isii ,&nbsp;Yuji Kamashita ,&nbsp;Naohiro Shimotahira ,&nbsp;Fumio Suehiro ,&nbsp;Yasuhiro Nishi ,&nbsp;Hiroshi Murata ,&nbsp;Masahiro Nishimura","doi":"10.1016/j.pdpdt.2024.104434","DOIUrl":"10.1016/j.pdpdt.2024.104434","url":null,"abstract":"<div><div>Interest in ultraviolet (UV) light devices for disinfection has increased due to pandemic concerns, but their efficacy in denture disinfection is underexplored. This study evaluated seven-enclosed type portable UV irradiation devices (devices A–G). Among these, devices A, B, and C used bulb light sources, while devices D, E, F, and G utilized LED (light-emitting diode) light sources. All devices were assessed in agar plate assay, and <em>Candida albicans</em> and <em>Staphylococcus aureus</em> spread on agar plates and irradiated under two conditions: inoculated surface facing upward and downward. Colony counts were recorded. Devices A and D were tested on <em>C. albicans</em>-contaminated dentures immersed in <em>C. albicans</em> medium, with samples collected before and after irradiation on the mucosal surfaces of the dentures. Device A was tested on denture-wearing patients in a clinical study, with samples collected from mucosal surfaces before and after irradiation to assess microbial CFUs (colony forming units). Devices A, C, and D significantly reduced <em>C. albicans</em> and <em>S. aureus</em> on plates with the inoculated surface facing upward, while device F showed a slight reduction when the inoculated surfaces were facing downward. Devices A and D eliminated <em>C. albicans</em> on contaminated dentures in vitro. Device A reduced all microorganism CFUs on denture surfaces in clinical studies. This study demonstrates that some portable UV light devices effectively reduce microbial contamination on denture surfaces, suggesting their potential as valuable tools for improving denture hygiene in the future.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104434"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of retinal vascular abnormalities in the fellow eyes of children with Coats’ disease and normal subjects using ultra-widefield fundus fluorescein angiography","authors":"Shenshen Yan ,&nbsp;Haixia Ji ,&nbsp;Yuzhu Liu ,&nbsp;Haicheng She ,&nbsp;Haiying Zhou","doi":"10.1016/j.pdpdt.2024.104455","DOIUrl":"10.1016/j.pdpdt.2024.104455","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate retinal vascular abnormalities in the affected and fellow eyes of children with Coats’ disease using Optos® ultra-widefield fundus fluorescein angiography (UWFFA) and compare the peripheral vascular abnormalities between fellow eyes and normal control eyes.</div></div><div><h3>Methods</h3><div>Children diagnosed with Coats’ disease who underwent UWFFA were retrospectively reviewed. Healthy eyes with complete UWFFA data were selected as controls. Retinal vascular abnormalities of the primary affected, fellow eyes and normal control eyes were recorded by investigating the UWFFA images.</div></div><div><h3>Results</h3><div>Among the 190 eyes of 95 patients with unilateral Coats’ disease, 83 (87.4%) were male, and the median age was 9.00 (7.00, 12.25) years (4–18 years). 93 (97.9%) fellow eyes had peripheral capillary telangiectasia that most commonly located in the temporal periphery. 59 (62.1%) fellow eyes had microaneurysms and 19 (20.0%) had vascular leakage; 29 (30.5%) fellow eyes had peripheral vascular tortuosity and 86 (90.5%) eyes had peripheral right-angle vessels. Peripheral capillary non-perfusion (CNP) were found in 31.6% (30/95) fellow eyes. We also found that the terminal vascular patterns in the fellow eyes were mainly loop pattern, accounting for 90.5%. The incidence of capillary bed abnormalities, vascular leakage, right-angle vessels and CNP were significantly higher in fellow eyes of Coats’ disease than control eyes (p&lt;0.001, p=0.044, p&lt;0.001, p=0.001, respectively). Regarding the terminal vascular patterns, the proportion of loop pattern in fellow eye group was significantly higher than that in control eye group (p&lt;0.001). A total of 21 Coats’ patients had follow-up UWFFA data. The average follow-up time was 13.19±10.09 (3–35) months. There was no significant change in peripheral retinal vascular abnormalities in the fellow eye of all patients between the first and last visit.</div></div><div><h3>Conclusions</h3><div>Because Optos® UWFFA device is able to quickly take panoramic fundus images using mild excitation light without contacting the cornea, it allows the detection of peripheral vascular changes in the fellow eyes of children with Coats’ disease. Contrary to the previous belief that Coats’ disease is a “unilateral condition”, our finding shows that Coats’ disease appears to be a highly asymmetric bilateral disease, and the peripheral vascular abnormalities in the fellow eye remains stable in short term.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104455"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between choroidal thickness and rate of axial elongation in orthokeratology lens users","authors":"Riping Zhang ,&nbsp;Suoqing Zhuang ,&nbsp;Youming Zhou ,&nbsp;Man Pan Chin ,&nbsp;Lixia Sun ,&nbsp;Vishal Jhanji ,&nbsp;Mingzhi Zhang","doi":"10.1016/j.pdpdt.2024.104450","DOIUrl":"10.1016/j.pdpdt.2024.104450","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the impact of using orthokeratology lenses (OK lenses) for one year on the axial length (AL) and choroidal thickness (ChT) in the 6 mm concentric central retinal region.</div></div><div><h3>Methods</h3><div>36 myopic children (36 eyes) aged 8 to 16 years were enrolled. For the duration of one year, the OK group (18 subjects) utilized OK lenses, while the spectacles group (18 subjects) utilized single-vision spectacles as a control. Only their right eyes were used for analysis. ChT in nine regions of the retina was evaluated using optical coherence tomography. AL and other ocular parameters were measured using optical biometry. The measurements were obtained at baseline, 3 months, 6 months, and 12 months.</div></div><div><h3>Results</h3><div>After 12 months of treatment, the OK group showed a reduced rate of AL elongation. The first interval (baseline to 3 months) saw the most notable alteration (<em>p</em> &lt; 0.0001). ChT increased in most regions after wearing OK lenses, except for the nasal retinal region. However, the alteration in nasal ChT exhibited the strongest association with the alteration in AL.</div></div><div><h3>Conclusion</h3><div>The efficacy of myopia control with OK lenses is most pronounced during the initial months of wear. Alterations in the thickness of the nasal choroidal region may correlate with the elongation of the AL, implying its potential role as a biomarker for assessing the efficacy of OK lenses in myopia control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104450"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report","authors":"Xiaoqing Xiang ,&nbsp;Yanliang Li ,&nbsp;Can Shi ,&nbsp;Runqun Liu ,&nbsp;Guozhang Ma ,&nbsp;Yunyun Cao ,&nbsp;Lianheng Xia ,&nbsp;Jie Gao","doi":"10.1016/j.pdpdt.2024.104465","DOIUrl":"10.1016/j.pdpdt.2024.104465","url":null,"abstract":"<div><div>Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmesis. Photodynamic therapy (PDT) is an emerging, safe, and non-invasive technique utilizing a photosensitizer and a specific light source, widely applied in the treatment of malignancies and skin diseases. We report the case of a 74-year-old woman presenting with a large, dark brown patch on the vulva, histopathologically confirmed as BD. The patient also had lesions within the vagina. Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) was administered, with an optical fiber used for targeted treatment of the vaginal lesions. Complete resolution of the lesions was observed after a single treatment. A follow-up biopsy at 7 months post-treatment revealed no residual tumor cells. The patient remains disease-free at 2 years follow-up and continues to be monitored. This case suggests that HpD-PDT is a viable treatment option for BD, and may be particularly advantageous for elderly patients with extensive or vaginally located lesions, where preserving function and cosmesis is paramount.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104465"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic nerve head changes in acute central serous chorioretinopathy: Implications for glaucoma risk","authors":"Esma Ecem Ersoy,&nbsp;Ebubekir Durmuş","doi":"10.1016/j.pdpdt.2025.104478","DOIUrl":"10.1016/j.pdpdt.2025.104478","url":null,"abstract":"<div><h3>Objective</h3><div>Imaging techniques have demonstrated changes in the choroid and retina in acute central serous chorioretinopathy (CSCR), but the effects on the optic nerve head (ONH) remain unclear. This study investigates ONH structural changes in acute CSCR using enhanced deep imaging optical coherence tomography (EDI-OCT).</div></div><div><h3>Methods</h3><div>A prospective cohort study included 51 acute CSCR patients and 51 healthy controls aged 18–65 years. Patients had symptoms for less than three months, with no prior treatment or ocular pathology. Participants with refractive errors of ±6D spherical or less and ±3D cylindrical or less were included, while with optic nerve/choroidal conditions, corticosteroid use, systemic diseases like sleep apnea, and media opacities were excluded. Comprehensive eye exams and EDI-OCT were performed to evaluate retinal, choroidal, and ONH parameters.</div></div><div><h3>Results</h3><div>The mean subfoveal choroidal thickness (SFCT) (434.51±95.45 µm vs. 289.55±87.21 µm) and peripapillary choroidal thickness (PPCT) (282.12±79.14 µm vs. 180.79±53.99 µm) were significantly higher in the CSCR group compared to controls (<em>p</em> &lt; 0.001 for both). Retinal nerve fiber layer (RNFL) (107.14±15.15 µm vs. 101.06±14.31 µm, <em>p</em> = 0.04) and lamina cribrosa thickness (LCT) (307.14±63.83 µm vs. 200.04±54.23 µm, <em>p</em> &lt; 0.001) were significantly higher, while anterior laminar depth (ALD) and Bruch's membran opening-minimum rim width (BMO-MRW) were significantly lower in the acute CSCR.</div></div><div><h3>Conclusion</h3><div>In acute CSCR, increased SFCT is accompanied by a corresponding rise in PPCT, leading to significant ONH structural changes and enhanced blood flow, potentially offering glaucoma protection. However, further research is needed to explore the long-term effects of chronic CSCR on choriocapillaris ischemia and optic nerve.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104478"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosing intervals in Comparison of one-year real-world outcomes between red (670 nm) subthreshold micropulse laser treatment and intravitreal aflibercept injection for treatment-naïve diabetic macular edema","authors":"Kai Ching Peter Leung,&nbsp;Sunny, Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104484","DOIUrl":"10.1016/j.pdpdt.2025.104484","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104484"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment","authors":"Hanhan Chen ,&nbsp;Honglin Li ,&nbsp;Huijie Li ,&nbsp;Zhen Zhang","doi":"10.1016/j.pdpdt.2025.104472","DOIUrl":"10.1016/j.pdpdt.2025.104472","url":null,"abstract":"<div><h3>Background</h3><div>Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma.</div></div><div><h3>Objective</h3><div>To systematically evaluate the existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality and strength while performing updated meta-analyses to refine survival outcomes.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to September 18, 2024, to identify meta-analyses and clinical studies on PDT in patients with cholangiocarcinoma. The random-effects model was employed to re-synthesize existing meta-analyses, with a comprehensive evaluation of methodological quality. Updated meta-analyses of survival data were conducted, including subgroup analyses stratified by cholangiocarcinoma type and intervention modality.</div></div><div><h3>Results</h3><div>A total of 5 meta-analyses and 21 clinical studies were included. The findings indicated that combining PDT with stenting or chemotherapy can significantly improve overall survival in patients with cholangiocarcinoma and reduce mortality rate, without increasing the risk of adverse events (AEs) such as cholangitis or abscess formation. For extrahepatic cholangiocarcinoma, adding PDT to stenting demonstrated a notable improvement in the 2-year survival rate. Meanwhile, for hilar cholangiocarcinoma, the addition of chemotherapy to PDT showed a more pronounced enhancement in the 1-year survival rate.</div></div><div><h3>Conclusion</h3><div>Current evidence indicates that PDT combined with stenting or chemotherapy in the palliative treatment of cholangiocarcinoma decreases overall mortality and enhances OS without increasing the incidence of AEs. Adding PDT to stenting or chemotherapy may be more beneficial for long-term efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104472"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}