Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Prediction model for the risk of vitreous haemorrhage after vitrectomy combined with intraocular injection for the treatment of proliferative diabetic retinopathy","authors":"Shasha Yao,&nbsp;Chunfang Gan,&nbsp;Rugang Pan","doi":"10.1016/j.pdpdt.2025.105313","DOIUrl":"10.1016/j.pdpdt.2025.105313","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to develop a lightweight multimodal deep learning model for accurately predicting the risk of postoperative vitreous cavity haemorrhage (POVCH) following vitrectomy with intraocular pharmacotherapy in patients with proliferative diabetic retinopathy (PDR).</div></div><div><h3>Methods</h3><div>This retrospective study included patients with PDR who underwent vitrectomy combined with intraocular medication for the first time. After applying the exclusion criteria, 1318 eyes from 968 patients were analysed. A lightweight multimodal deep learning model was developed by integrating ultra-widefield fluorescein angiography images, processed using an EfficientNet-V2 backbone, using clinical data from a multilayer perceptron. The model was trained and evaluated using a stratified four-fold cross-validation approach, and an independent external test set comprising 264 eyes was used to assess generalisability.</div></div><div><h3>Results</h3><div>On the external test set, the model achieved an area under the receiver operating characteristic curve (AUROC) of 0.978 (95 % CI: 0.952–0.994) and an area under the precision-recall curve of 0.957. Accuracy was 0.914, with a Brier score of 0.056. The model demonstrated excellent calibration (slope: 0.97; intercept: −0.03). Decision curve analysis indicated a net benefit increase of 0.031 at a 25 % risk threshold. Interpretability analyses revealed that the model’s focus, via Gradient-weighted Class Activation Mapping Plus, aligned with clinical areas of neovascularisation and retinal ischaemia. SHapley Additive exPlanations analysis identified the ischaemia index, leakage index and neovascularisation area as key predictors. The model outperformed the best traditional CatBoost model, with an absolute AUROC improvement of 0.09.</div></div><div><h3>Conclusion</h3><div>The lightweight multimodal deep learning model integrating ultra-widefield fluorescein angiography images and clinical data demonstrated advantages in predicting the risk of POVCH after PDR surgery, with high accuracy, good calibration, excellent clinical utility and interpretability and low resource requirements.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105313"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior segment structural changes across myopia severity and their association with myopia progression: A large-scale clinical analysis","authors":"He Du ,&nbsp;Bo Deng ,&nbsp;Yang Cao","doi":"10.1016/j.pdpdt.2026.105352","DOIUrl":"10.1016/j.pdpdt.2026.105352","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the variations in anterior segment parameters among patients with different degrees of myopia and explore their impact on myopia progression.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on ocular parameters of 4392 patients who underwent myopia correction surgery at the affiliated hospital of Southwest Medical University from January 2019 to January 2023. The patients were categorized into mild, moderate, and high myopia groups based on the severity of their myopia. Measurements of corneal thickness (CCT), intraocular pressure (IOP), axial length (AL), steep corneal curvature (Ks), flat corneal curvature (Kf), white-to-white corneal diameter (WTW), pupil diameter under bright conditions (LPD), pupil diameter under dark-adapted conditions (DPD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber depth (ACD), and Kappa angle values (Kx and Ky) were performed and analyzed using SPSS 28.0 software.</div></div><div><h3>Results</h3><div>Significant differences were observed in most of the aforementioned parameters among patients with different degrees of myopia. With increasing myopia severity, CCT, IOP, AL, Ks, Kf, CV, ACV, ACD, and Ky exhibited a gradual increase (all <em>P</em> &lt; 0.05), while WTW and DPD showed a gradual decrease (all <em>P</em> &lt; 0.05). Kx and LPD did not exhibit statistically significant differences (<em>P</em> &gt; 0.05). Correlation analysis revealed significant positive correlations between IOP and the degree of myopia (OR = 1.02, <em>P</em> = 0.005), WTW and the degree of myopia (OR = 0.47, <em>P</em> &lt; 0.001), ACV and the degree of myopia (OR = 1.01, <em>P</em> &lt; 0.001), and significant negative correlations between ACD and the degree of myopia (OR = 0.83, <em>P</em> = 0.031). Ky showed a significant positive correlation with the degree of myopia (OR = 2.55, <em>P</em> &lt; 0.001). These findings provide further evidence of the association between ocular parameters and myopia progression.</div></div><div><h3>Conclusion</h3><div>Significant differences exist in anterior segment parameters among patients with varying degrees of myopia, which may be related to myopia progression. Further investigation into the relationship between these parameters and the development of myopia will contribute to a better understanding of the underlying mechanisms and provide a theoretical basis for scientific myopia prevention and control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105352"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data of verteporfin-related ocular adverse events: A disproportionality analysis","authors":"Nesrin Caglayan Duman ,&nbsp;Aslihan Uzun","doi":"10.1016/j.pdpdt.2025.105322","DOIUrl":"10.1016/j.pdpdt.2025.105322","url":null,"abstract":"<div><h3>Aim/Background</h3><div>To investigate verteporfin-induced ocular adverse events (AEs) by analysing real-world data reported in the US Food and Drug Administration's Adverse Event Reporting System (FAERS) database.</div></div><div><h3>Methods</h3><div>The OpenVigil 2.1-MedDRA-v24 disproportionality analysis software package, including the Reporting Odds Ratio (ROR) and Proportional Reporting Ratio (PRR) algorithms, was used to detect potential ocular AEs associated with verteporfin and to determine signal intensity. AE reports related to verteporfin as the primary suspect in the FAERS database between 01 January 2004 and 31 December 2024 were included in the study. The signal strengths were classified as low, medium and strong according to the ROR and PRR values.</div></div><div><h3>Results</h3><div>The most reported preferred terms (PTs) were ‘visual acuity reduced’ (<em>n</em> = 212), ‘retinal haemorrhage’ (<em>n</em> = 100), and ‘choroidal neovascularization’ (<em>n</em> = 77). However ‘polypoidal choroidal vasculopathy’ (ROR=3538.345, PRR=3420.433), ‘subretinal fibrosis’ (ROR=3376.777, PRR=3283.005) and ‘macular scar’ (ROR=2458.542, PRR=2414.169) had the highest signal strength. The results of disproportionality analysis of PTs with 3 or more ‘eye disorder’ reports associated with verteporfin (<em>n</em> = 52), revealed 40 strong, 7 moderate, and 5 weak signal intensities.</div></div><div><h3>Conclusion</h3><div>The most common verteporfin-related ocular AEs (reduced visual acuity, retinal haemorrhage and choroidal neovascularization) were consistent with the drug label. However dozens of new potential ocular AEs with strong signal strengths that were not listed in the drug label, were identified. It should be noted that the proportional data in the study cannot provide information about other drugs used for the same indications as verteporfin. A fully-comprehension of these AEs will be highly beneficial in deciding which patients should be closely monitored for verteporfin-related ocular AEs. However, we emphasis our view that this study should be supported by prospective, clinically conducted research, as data on verteporfin's therapeutic indications and dosage are unavailable in this study.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105322"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agent-specific differences in sustained intraoperative hypotension during oral 5-Aminolevulinic acid-guided transurethral resection of bladder tumor: A retrospective observational study","authors":"Yoshifumi Katsumata ,&nbsp;Shinkuro Yamamoto ,&nbsp;Hideki Iwata ,&nbsp;Hajime Kuroiwa ,&nbsp;Hideo Fukuhara ,&nbsp;Satoshi Fukata ,&nbsp;Keiji Inoue ,&nbsp;Takashi Kawano","doi":"10.1016/j.pdpdt.2025.105319","DOIUrl":"10.1016/j.pdpdt.2025.105319","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe intraoperative hypotension is frequently reported during transurethral resection of bladder tumor (TURBT) using orally administered 5-aminolevulinic acid hydrochloride (5-ALA); however, the influence of anesthetic technique on prolonged hypotensive episodes remains unclear.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 423 consecutive patients who underwent oral 5-ALA-guided TURBT between 2018 and 2024. Sustained hypotension was defined as mean arterial pressure &lt;65 mmHg lasting ≥30 min. Baseline characteristics, anesthetic variables, and hemodynamic parameters were compared between patients with and without sustained hypotension. Multivariable logistic regression was used to identify independent predictors.</div></div><div><h3>Results</h3><div>Among patients receiving general anesthesia (n=274), the incidence of sustained hypotension varied significantly depending on the anesthetic agent (p=0.02). In multivariable logistic regression, remimazolam was independently associated with a significantly lower risk of sustained hypotension compared with sevoflurane (adjusted OR 0.35, 95% CI 0.14–0.83, p=0.02).</div></div><div><h3>Conclusions</h3><div>Approximately one-fourth of patients undergoing oral 5-ALA–guided TURBT experienced sustained intraoperative hypotension, with spinal anesthesia showing a lower incidence than general anesthesia. Longer anesthesia and surgical durations increased the risk. The choice of anesthetic agents under general anesthesia also appeared to affect the risk of sustained hypotension. These findings highlight the importance of individualized anesthetic management to maintain hemodynamic stability during this procedure.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105319"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of orthokeratology lenses on axial length, refractive power, and complications in myopic children under corneal curvature stratification","authors":"Feifei Shi,&nbsp;Feidi Li,&nbsp;Qunwu Tang,&nbsp;Huifeng Wu","doi":"10.1016/j.pdpdt.2025.105326","DOIUrl":"10.1016/j.pdpdt.2025.105326","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the long-term effects of orthokeratology lenses (OK lenses) on myopic children with different baseline corneal curvatures (CCs).</div></div><div><h3>Methods</h3><div>178 myopic children were categorized into three groups based on their CC: Axial Group (AG, CC ≤41.5D), Curvature Group (CG, CC ≥44D), and Mixed Group (MG, 41.5D ≤ CC ≤44D). The age range was from 6 to 15 years. The refractive error (RE), axial length (AL), CC, RE changes, axial elongation rate, changes in CC, corneal endothelial cell (CEC) parameters, and complications were compared among the three groups.</div></div><div><h3>Results</h3><div>After wearing glasses, the patients’ RE, CC, AL, and axial growth rate in all three groups were significantly improved compared to before wearing glasses (<em>P</em>&lt;0.05). The differences in AL increase at different time points after wearing glasses were not statistically significant (<em>F</em> = 10.20, <em>P</em> &gt; 0.05). The changes in CC in the AG were significantly different from those in the CG (<em>P</em> &lt; 0.05), and the AG showed a greater increase in AL after treatment compared to the CG and MG (<em>P</em> &lt; 0.05). For instance, the mean CC in the AG before wearing glasses was 41.82 ± 0.79D, which decreased to 38.17 ± 0.59D after two years of wearing glasses. In the CG, the mean CC before wearing glasses was 43.69 ± 1.57D, decreasing to 42.87 ± 1.08D after two years of wearing glasses. The differences in CEC density, mean cell area, coefficient of variation (COA), and hexagonal cell ratio (HCR) at various time points before and after wearing glasses and between the different groups were minimal (<em>P</em> &gt; 0.05). The complication rate was 58.62% in the AG, 41.82% in the CG, and 53.85% in the MG, with the CG showing the lowest complication rate after two years, which was significantly different from the other two groups (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>OK lenses demonstrate marked efficacy in controlling myopia, particularly in patients with higher CC, where the control of AL growth is notably effective. Additionally, CC is associated with the incidence of complications.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105326"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of laughter exercise on intraocular pressure, Schlemm’s canal and chorioretinal parameters in healthy adults","authors":"Yunkao Zeng ,&nbsp;Kityee Ng ,&nbsp;Wanni Chen,&nbsp;Yue Zhou,&nbsp;Yan Mao,&nbsp;Jinfei Lu,&nbsp;Junming Wang","doi":"10.1016/j.pdpdt.2026.105339","DOIUrl":"10.1016/j.pdpdt.2026.105339","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigated the effects of laughter exercise on IOP, anterior and posterior segment parameters in healthy adults.</div></div><div><h3>Methods</h3><div>This study involved 23 healthy adults who underwent baseline and post-intervention measurements of IOP and ocular structures. Using swept-source OCT(SS-OCT), we quantified Schlemm’s canal area (SCAR) and trabecular meshwork thickness across four quadrants, and assessed posterior segment parameters with a 24 × 20 mm ultra-widefield protocol. Measurements were repeated at 1, 15, 30, and 60 min after a 5-minute standardized laughter exercise to analyze longitudinal changes and IOP correlations.</div></div><div><h3>Results</h3><div>IOP significantly decreased at 1, 15, and 30 min after laughter exercise (all <em>p</em> &lt; 0.01), then recovered at 60 min(<em>p</em> = 0.131). The nasal SCAR significantly enlarged at 15 min(<em>p</em> &lt; 0.001) and 30 min post-exercise(<em>p</em> = 0.004). Temporal SCAR only showed significant increase at 1 min post-exercise(<em>p</em> = 0.025). The superior SCAR significantly enlarged at 1 min(<em>p</em> = 0.008) and 30 min(<em>p</em> = 0.041) post-exercise. Inferior SCAR remained stable throughout the study period(<em>p</em> = 0.204). The trabecular meshwork thickness in all 4 quadrants only exhibited significant increase at 1 min post-exercise(all <em>p</em> &lt; 0.01). No significant changes in chorioretinal parameters were noted (all <em>p</em> &gt; 0.05). In the multivariate model, retinal superficial capillary plexus vessel density positively corelated with IOP (β=4.00, <em>p</em> = 0.009), whereas nasal SCAR demonstrated a negative correlation (β=-2.40, <em>p</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>The anterior and posterior segment demonstrated distinct responses to a standardized laughter exercise. The IOP changes are associated with the expansion of Schlemm’s canal. Further research is warranted to determine the efficacy of laughter exercise as a non-pharmacological adjunct for IOP control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105339"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D analysis of age-related compensation of retinal capillary plexuses in normal population via wide-field volume-mode SS-OCTA: Focus on interlayer connecting branches","authors":"Xindi Liu ,&nbsp;Nianjia Wang ,&nbsp;Meizhu Wang ,&nbsp;Qi Gao ,&nbsp;Menglu Chen ,&nbsp;Liang Yao ,&nbsp;Juan Ye","doi":"10.1016/j.pdpdt.2026.105350","DOIUrl":"10.1016/j.pdpdt.2026.105350","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the age-related compensatory features of retinal capillary plexuses (RCP) in normal people, with emphasis on the role of interlayer connecting branches.</div></div><div><h3>Methods</h3><div>Wide-field volume-mode swept-source optical coherence tomography angiography (SS-OCTA) B-scans of 3 × 3 mm and 12×12 mm of 60 healthy eyes were collected. Pearson correlation analyzed blood flow indices including blood volume (BV), vessel surface area (VSA), and vessel density (VD); 3D volume rendering observed interlayer connecting branches.</div></div><div><h3>Results</h3><div>1. Blood flow compensation: 3 × 3 mm macular BV and VSA showed no correlation with age; BV and VSA in the 12×12 mm area decreased with age. Only the macular VD of the intermediate capillary plexus (ICP) dropped significantly, with a correlation coefficient twice that of the superficial vascular plexus (SVP) and deep capillary plexus (DCP). 2. Interlayer branches: Three types were identified: small, vertical ones (prevalent in young people) and two types of large, oblique ones (prominent in the elderly). With age, total branch number decreased, more markedly in vertical ones; oblique ones became dominant, accompanied by reduced small vessels (most marked in ICP) and thickened large vessels (most prominent in DCP).</div></div><div><h3>Conclusion</h3><div>Normal RCP has an age-related compensatory mechanism: \"sacrificing peripheral blood flow to protect macular blood flow\". This compensation is supported by interlayer branch changes: vertical branches decrease while oblique branches become relatively dominant. It maintains macular blood flow and central vision, helping distinguish normal aging from pathological vascular damage.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105350"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined feature-based classification of premalignant and malignant oral lesions using VELscope endogenous fluorescence imaging and dry serum Raman spectroscopy","authors":"Mukta Sharma ,&nbsp;Chia-Lung Tsai ,&nbsp;M.V. Arularasu ,&nbsp;Shiang-Fu Huang ,&nbsp;Yu-Li Hsieh ,&nbsp;Liann-Be Chang","doi":"10.1016/j.pdpdt.2025.105247","DOIUrl":"10.1016/j.pdpdt.2025.105247","url":null,"abstract":"<div><h3>Background:</h3><div>Accurate differentiation between premalignant and malignant oral lesions is critical for improving clinical management and patient outcomes. This study explores a multimodal diagnostic approach, uniquely combining endogenous fluorescence imaging, Visually Enhanced Lesion Scope (VELscope) and dry serum Raman spectroscopy features, to enhance lesion classification.</div></div><div><h3>Methods:</h3><div>Patients with histologically confirmed premalignant and malignant oral lesions were included. Endogenous fluorescence images and corresponding Raman spectra from dry serum samples were collected from a total of 66 patients. Features extracted from both modalities were integrated (feature fusion) and evaluated using a Gaussian Naïve Bayes classifier. Due to limited sample size, the model was trained and cross-validated using the complete dataset. Diagnostic performance was assessed via accuracy, precision–recall (PR) analysis, and decision boundary visualization.</div></div><div><h3>Results:</h3><div>The multimodal fusion approach yielded an accuracy of 86%, with a precision–recall curve area under the curve (AUC) of 0.94, demonstrating robust discrimination between malignant and premalignant lesions. Decision boundary visualization illustrated effective nonlinear separation, underscoring the complementary nature of combined imaging and biochemical features.</div></div><div><h3>Conclusion:</h3><div>Integrating VELscope endogenous fluorescence imaging and dry serum Raman spectroscopy provides enhanced diagnostic accuracy for oral lesion classification. This multimodal feature fusion approach demonstrates potential clinical utility, particularly within small, high-dimensional biomedical datasets, warranting further validation in larger patient cohorts.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105247"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonodynamic therapy with chemo-radiotherapy in high-grade brainstem gliomas: A prospective phase IIa clinical trial","authors":"Xiaohao Liu ,&nbsp;Linkuan Huangfu ,&nbsp;Long Wang ,&nbsp;Jiayin Ding ,&nbsp;Tianqi Li ,&nbsp;Yahang Liu ,&nbsp;Yue Yu ,&nbsp;Miaomiao Zhang ,&nbsp;Zhifei Dai ,&nbsp;Yingjuan Zheng","doi":"10.1016/j.pdpdt.2025.105296","DOIUrl":"10.1016/j.pdpdt.2025.105296","url":null,"abstract":"<div><div>The treatment of high-grade brainstem gliomas (HBSGs), which are a type of malignant neoplasm, is challenging. There is a need to develop novel and effective therapeutic approaches for HBSGs. This study analyzed the data between sonodynamic therapy (SDT) group and control groups. 24 patients with HBSGs who were treated with the combination of SDT and Stupp regimen served as SDT group. Admitted patients (n = 39) during the same period in our hospital,receiving only the Stupp regimen served as the control group. Most SDT-related adverse events (AEs) were classified as grade 1–2, indicating manageable safety risks. The incidence rates of severe AEs were not significantly different between the two groups. The median progression-free survival (PFS) and overall survival (OS) were not significantly different between the SDT and control groups. However, the 6-month PFS rate (<em>P</em> = 0.009), 1-year PFS rate (<em>P</em> = 0.021), objective response rate(ORR) (<em>P</em> = 0.044), median duration of disease control(DDC) (<em>P</em> = 0.002), median duration of response(DOR) (<em>P</em> = 0.010), and improvement in Karnofsky Performance Status(KPS) scores at month 1 post-treatment in the SDT group were significantly superior than those in the control group (<em>P &lt;</em> 0.001). In the SDT group, the median OS of patients undergoing &lt; 2 and ≥ 2 SDT cycles of treatment was 14.9 (95% CI: 6.9–22.9) and 20.9 months (95% CI: 16.5–25.3), respectively (<em>P</em> = 0.003). SDT and chemoradiotherapy combination was associated with favorable safety and dose-dependent survival benefit in patients with HBSGs, indicating its therapeutic potential.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105296"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ABO and Rh blood groups and choroidal structural parameters in adult population","authors":"Özkan Kocamış,&nbsp;Tülay Karacan Erşekerci,&nbsp;Kemal Örnek","doi":"10.1016/j.pdpdt.2025.105328","DOIUrl":"10.1016/j.pdpdt.2025.105328","url":null,"abstract":"<div><h3>Background</h3><div>The ABO and Rh blood group systems have been associated with various systemic and ocular diseases. The choroid, as the most vascularized ocular structure, plays a critical role in retinal health. The choroidal vascularity index (CVI) has emerged as arobust metric for evaluating choroidal structure. This study aimed to investigate the association between ABO and Rh blood groups and choroidal structural parameters, including CVI, in a healthy adult population.</div></div><div><h3>Methods</h3><div>This prospective study included 164 healthy participants who underwent comprehensive ophthalmologic examination, including enhanced depth imaging optical coherence tomography (EDI-OCT). Subfoveal choroidal parameters—stromal area (SA), luminal area (LA), total choroidal area (TCA), and CVI—were measured using Image-J software. Participants were grouped according to ABO and Rh blood types. Statistical comparisons were conducted using Kruskal-Wallis, Mann-Whitney U, Chi- Square, and Spearman correlation tests.</div></div><div><h3>Results</h3><div>Among the 164 participants (55.5% female), blood type distributions were: A (36.6%), B (20.1%), AB (15.9%), and O (27.4%). Statistically significant differences were found between ABO blood groups for SA, LA, and TCA (<em>p</em> &lt; 0.05). Blood group B exhibited significantly higher SA, LA, and TCA compared to other groups. However, CVI did not differ significantly among ABO or Rh groups (<em>p</em> &gt; 0.05). No correlations were observed between age or axial length and choroidal parameters.</div></div><div><h3>Conclusion</h3><div>While SA, LA, and TCA values vary across ABO blood groups—particularly elevated in blood group B—CVI remains stable, suggesting a proportional expansion of stromal and vascular components. These findings imply a potential genetic influence of blood group antigens on choroidal morphology without affecting vascular density. Further large-scale, multiethnic studies are warranted to validate these associations.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"57 ","pages":"Article 105328"},"PeriodicalIF":2.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}