Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Three Decades of Photodynamic Therapy for Glioblastoma: A Comprehensive Scientometric Analysis","authors":"Jiheng Zhang ,&nbsp;Xiuwei Yan ,&nbsp;Xin Gao ,&nbsp;Jiahe Hu ,&nbsp;Hongtao Zhao ,&nbsp;Chengyun Yang ,&nbsp;Lei Xu ,&nbsp;Yapeng Niu ,&nbsp;Mo Geng ,&nbsp;Nan Wang ,&nbsp;Shaoshan Hu","doi":"10.1016/j.pdpdt.2025.104533","DOIUrl":"10.1016/j.pdpdt.2025.104533","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) has emerged as a promising adjunctive treatment for glioblastoma (GBM), yet a comprehensive bibliometric analysis of this field is lacking. This study explores research trends, major contributors, and hotspots in PDT for GBM to provide an integrated overview of its development.</div></div><div><h3>Methods</h3><div>Literature from 1993 to 2024 was retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace, analyzed publication trends, collaborations, and keyword co-occurrence to identify influential authors, institutions, and journals.</div></div><div><h3>Results</h3><div>A total of 799 publications showed a growing research interest, peaking in 2022. The United States and China were leading contributors, with prominent institutions like the University of California System and Centre National de la Recherche Scientifique. Influential figures, such as Jiro Akimoto and Walter Stummer, advanced clinical applications and fluorescence-guided techniques. Early studies of PDT for GBM have focused on evaluating its efficacy and potential side effects, while recent research has transitioned toward innovative strategies like targeted drug delivery, nanotechnology, and combination therapies. However, the similarities between early and recent studies are in the search for safe and reliable photosensitizers. Keyword analysis highlighted \"5-aminolevulinic acid\", \"in vitro\", and \"polyethylene glycol compounds\" as key areas, while timeline analysis revealed shifts from foundational photosensitizer research to approaches addressing tumor heterogeneity and resistance.</div></div><div><h3>Conclusions</h3><div>This study provides a systematic overview of PDT research for GBM, spotlighting breakthroughs and collaborative networks. The findings emphasize the importance of innovation and clinical translation to fully realize PDT's potential in GBM therapy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104533"},"PeriodicalIF":3.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of surgical management combined with photodynamic therapy in the treatment of nontuberculous mycobacterial infections after cosmetic surgery","authors":"Huiling Kou ,&nbsp;Xinying Li ,&nbsp;Hailin Wang ,&nbsp;Yunchuan Yang ,&nbsp;Menggang Liu","doi":"10.1016/j.pdpdt.2025.104545","DOIUrl":"10.1016/j.pdpdt.2025.104545","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, the number of patients with nontuberculous mycobacteria (NTM) infections caused by invasive procedures such as cosmetic surgery has been increasing. However, treating NTM infections presents significant challenges, with no standardized diagnostic or treatment guidelines currently available.</div></div><div><h3>Methods</h3><div>This study included 10 patients diagnosed with skin and soft tissue NTM infections following cosmetic surgery. Each patient underwent surgical treatment, followed by Photodynamic therapy (PDT) after debridement. PDT was performed using topical 20 % 5-aminolevulinic acid (ALA, 2 mL: 10 mg) applied to the wound periphery (2 cm margin), followed by a 3-hour incubation under light occlusion and activation with a 635 nm diode laser at an energy density of 120 J/cm². Exposure durations were dynamically adjusted (20–40 min) based on real-time pain tolerance. Weekly PDT sessions were administered, with total treatment duration individualized according to wound healing progression. Post-procedural pain was assessed using the Facial Expression Pain Scale (FEPS) and managed through a tiered protocol: ice compression for mild-to-moderate pain (FEPS 2–4) and NSAIDs/opioids for severe pain (FEPS &gt;4). Antibiotics were selected based on the results of drug susceptibility testing.</div></div><div><h3>Results</h3><div>All ten patients achieved clinical cure, with a notable reduction in the duration of therapy. All patients were followed for over six months without recurrence of infection. Post-PDT pain was universally in all patients, with FEPS scores ranging from 2 to 7, and managed effectively by the final treatment. Transient adverse events included erythema (<em>n</em> = 10) and pruritus (<em>n</em> = 2), resolving spontaneously within 48 h. No chronic complications were observed.</div></div><div><h3>Conclusion</h3><div>The combination of surgical intervention and PDT, along with appropriate antibiotic therapy, may be a safe and effective approach for treating skin and soft tissue NTM infections after cosmetic surgery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104545"},"PeriodicalIF":3.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of efficacy of ALA-PDT and CO2 laser in the treatment of vaginal intraepithelial neoplasia II (VaIN II)","authors":"Huixiang Ji ,&nbsp;Yufang Xia ,&nbsp;Huihui Cai ,&nbsp;Zhaoxia Ding ,&nbsp;Hailong Guo ,&nbsp;Hui Liu ,&nbsp;Yanhui Lou","doi":"10.1016/j.pdpdt.2025.104543","DOIUrl":"10.1016/j.pdpdt.2025.104543","url":null,"abstract":"<div><h3>Objective</h3><div>To compare and analyze the efficacy as well as adverse effects of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) and carbon dioxide (CO₂) laser therapy in the treatment of vaginal intraepithelial neoplasia II (VaIN II), and assess the feasibility, safety, and influencing factors of ALA-PDT.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted on the clinical data of 79 patients with VaIN II (PDT group = 37, Laser group = 42) who were treated at the Gynecology Department of the Affiliated Hospital of Qingdao University from January 2022 to January 2024. Follow-up evaluations were carried out at 3, 6, and 12 months after treatment. During these follow-ups, human papillomavirus (HPV) testing, cervical liquid-based cytology (TCT), colposcopy, and vaginal lesion biopsy were utilized to assess key outcomes, including the lesion reversal rate, HPV clearance, and treatment-related adverse reactions in both groups.</div></div><div><h3>Results</h3><div>The lesion reversal rates following ALA-PDT treatment were 83.3 %, 86.1 %, and 88.2 % at 3, 6, and 12 months, respectively. There was no significant difference when compared to the laser group. However, the negative HPV conversion rates at 6 and 12 months after ALA-PDT treatment were 73.5 % and 87.5 %, respectively, which were significantly higher than those observed in the CO₂ laser group (<em>P</em> &lt; 0.05). Adverse events related to photodynamic therapy occurred in 13.5 % (5/37) of the cases, which was significantly lower than the 35.7 % (15/42) in the laser group. In the laser group, increased incidences of vaginal bleeding and scarring were observed. Logistic univariate regression analysis revealed that factors such as a disease duration of &gt;1 year, multifocal lesions, and a history of cervical cancer or precancerous surgery negatively influenced lesion reversal at 6 months after ALA-PDT treatment (<em>P</em> &lt; 0.05). Additionally, factors like patient age over 50 years old (menopause), having more than two pregnancies, an imbalance in the vaginal microbiota, a prolonged HPV infection (lasting &gt;1 year), and HPV superinfection affected HPV clearance at 6 months after ALA-PDT treatment (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>For the treatment of VaIN II, ALA-PDT exhibits equivalent lesion reversal rates and superior HPV clearance compared to CO₂ laser treatment, while causing minimal anatomical disruption to the vaginal tissue.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104543"},"PeriodicalIF":3.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient gingival health screening using biofluorescence of anterior dental biofilms","authors":"Hyo-Jung Kim,&nbsp;Eun-Song Lee,&nbsp;Baek-Il Kim","doi":"10.1016/j.pdpdt.2025.104546","DOIUrl":"10.1016/j.pdpdt.2025.104546","url":null,"abstract":"<div><h3>Purpose</h3><div>In study, we aimed to evaluate the biofluorescence of anterior dental biofilms using Quantitative Light-induced Fluorescence (QLF) technology to screen for gingival health.</div></div><div><h3>Methods</h3><div>Fifty-five (<em>n</em> = 55) adult participants aged ≥ 20 years with gingivitis were included in this study. Fluorescence images of the upper and lower anterior teeth were obtained using Qraycam Pro, a device based on the QLF technology. To evaluate the biofilm fluorescence deposition level, the percentage of the dental biofilm area detected using red biofluorescence was calculated relative to the total surface area of the anterior teeth. To evaluate the gingival health status, the Silness-Lӧe plaque index (PI), Lӧe -Silness gingival index (GI), and bleeding-on-probing index (BOP) were assessed. Pearson's correlation and logistic regression analyses were performed to examine the relationship between biofilm biofluorescence and the gingival health status.</div></div><div><h3>Results</h3><div>The group with the larger fluorescent biofilm area exhibited significantly higher GI and BOP values (<em>p</em> &lt; 0.05) than the group with the smaller fluorescent biofilm area. Furthermore, significant correlations were found between the fluorescent biofilm area and GI, BOP, and PI (<em>r</em> = 0.422, <em>r</em> = 0.376, and <em>r</em> = 0.499, respectively; <em>p</em> &lt; 0.05). Logistic regression analysis adjusted for sociodemographic variables, smoking, and alcohol consumption showed that the odds ratio for moderate gingivitis in the group with a larger fluorescent biofilm area was 6.07 compared with that in the group with a smaller area (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Evaluating the biofluorescence of anterior dental biofilms using QLF technology is an effective indicator for screening gingival health and identifying individuals at a high risk for gingivitis.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104546"},"PeriodicalIF":3.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical value of reflectance confocal microscopy in monitoring treatment of actinic keratosis: A systematic review","authors":"Jinrui Zhang,&nbsp;Haolong Ran,&nbsp;Yongyao Zhao,&nbsp;Xiyu Liang,&nbsp;Zhiqian Gu,&nbsp;Yanning Xue","doi":"10.1016/j.pdpdt.2025.104539","DOIUrl":"10.1016/j.pdpdt.2025.104539","url":null,"abstract":"<div><h3>Background</h3><div>Actinic keratosis (AK) is a precancerous skin lesion that can progress to squamous cell carcinoma (SCC). Early diagnosis and effective treatment are crucial, but current treatment evaluation methods lack consistency. Reflectance confocal microscopy (RCM) has emerged as a promising non-invasive tool for monitoring treatment outcomes in AK, but the absence of standardized evaluation protocols limits its clinical applicability.</div></div><div><h3>Objective</h3><div>This study aims to establish standardized RCM imaging features for evaluating treatment responses in AK, thereby enhancing the consistency and clinical utility of RCM in treatment monitoring.</div></div><div><h3>Methods</h3><div>A systematic review was conducted following the PRISMA 2020 guidelines. Studies that evaluated the treatment of AK using RCM were included. A comprehensive literature search was performed across MEDLINE, Embase, and the Cochrane Library up to October 2024. Data on study design, treatment modalities, RCM imaging features, and scoring systems were extracted. A meta-analysis was not performed due to heterogeneity in study designs and outcome measures.</div></div><div><h3>Conclusion</h3><div>This review identifies key RCM imaging features of AK, including keratinocyte atypia and architectural disarray, and highlights the lack of a standardized scoring system for evaluating treatment outcomes. The findings underscore the need for a universally accepted protocol to improve the consistency and reliability of RCM in clinical practice. Standardization of RCM evaluation will enhance its utility in both clinical monitoring and future research on AK treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104539"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of foveal microstructural reconstruction after idiopathic macular hole surgery","authors":"Mengqi An ,&nbsp;Xiang Zhang ,&nbsp;Zetong Nie,&nbsp;Naxin Duan,&nbsp;Chang Liu,&nbsp;Xiaorong Li,&nbsp;Wenbo Li,&nbsp;Bojie Hu","doi":"10.1016/j.pdpdt.2025.104541","DOIUrl":"10.1016/j.pdpdt.2025.104541","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify prediction models and risk factors for anatomical microstructural reconstruction after surgery for idiopathic macular holes (IMHs).</div></div><div><h3>Methods</h3><div>This retrospective study involved 74 patients (77 eyes) who underwent successful closure after IMH surgery. The conventional MH indicators, macular hole occupancy index (MHOI) and internal limiting membrane (ILM) peeling index were calculated. Binary logistic regression analysis was used to identify prognostic factors and establish predictive models.</div></div><div><h3>Results</h3><div>The early postoperative anatomy of the inner segment/outer segment (IS/OS) showed a significant correlation with the MHOI, macular hole index (MHI), and traction hole index (THI) (<em>P</em> = 0.018, <em>P</em> = 0.047, <em>P</em> = 0.002, at-1-month; <em>P</em> = 0.008, <em>P</em> = 0.014, <em>P</em> = 0.005, at-3-months). Poorer preoperative best-corrected visual acuity (BCVA) (β = 2.954, <em>P</em> = 0.002) and larger inferior ILM peeling index (IIPI) (β = 7.446, <em>P</em> = 0.006) predicted poorer IS/OS prognosis. The early postoperative continuity of external limiting membrane (ELM) was significantly associated with the MHOI(<em>P</em> = 0.005), diameter hole index (DHI) (<em>P</em> = 0.031), MHI (<em>P</em> = 0.004), and THI (<em>P</em> &lt; 0.001). Larger IIPI (β = 8.490, <em>P</em> = 0.004 at-1-month) and poorer preoperative BCVA (β = 3.665, <em>P</em> = 0.001, at-1-month; β = 4.342, <em>P</em> = 0.002, at-3-months) were independent risk factors. Outer nuclear layer (ONL) disruption was significantly predicated by poorer preoperative BCVA (β = -2.781, <em>P</em> = 0.019) and larger IIPI (β = -5.653, <em>P</em> = 0.061). IS/OS and ELM integrity correlated with early postoperative BCVA, whereas the ONL showed sustained significance over 6 months.</div></div><div><h3>Conclusion</h3><div>MHOI, MHI, and THI influenced the repair of the IS/OS, ELM, and ONL in the short-term. Preoperative BCVA and IIPI were crucial for long-term prognosis of foveal microstructure. Foveal microstructure integrity is closely related to postoperative visual function recovery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104541"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus changes in healthy adults after high altitude exposure","authors":"Jiaxin Li ,&nbsp;Yunzhu Kong ,&nbsp;Peiyu Wang ,&nbsp;Chen Chen,&nbsp;Juping Liu,&nbsp;Xiaorong Li,&nbsp;Yan Shao","doi":"10.1016/j.pdpdt.2025.104542","DOIUrl":"10.1016/j.pdpdt.2025.104542","url":null,"abstract":"<div><h3>Background</h3><div>To quantify the changes of long-term high altitude (HA) exposure of fundus in healthy adults. The aim is to provide a reference for the prevention and treatment of high altitude ophthalmopathy.</div></div><div><h3>Methods</h3><div>30 eyes of 15 healthy participants exposed to high altitude were recruited in this study. Swept-source optical coherence tomography/Swept-source optical coherence tomography angiography (SS-OCT/SS-OCTA) was used to analyze fundus changes in participants before and after plateau exposure. Fundus metrics included best corrected visual acuity (BCVA), the thickness of the retina (ReT), Inner ReT, Outer ReT, nerve fiber layer thickness (RNFLT), and ganglion cell internal plexiform layer thickness (GCIPLT), vascular density (VD), the size of the perfusion area (PA), choroidal vessel volume (CVV), and choroidal vascularity index (CVI) in all quadrants of the macula. All metrics were analyzed by generalized estimating equations (GEE).</div></div><div><h3>Results</h3><div>Compared with baseline data, all participants who worked at high altitude for more than one year showed no change in visual acuity (<em>P</em> &gt; 0.05) and a decreased in ReT, Outer ReT, GCIPLT and VD in all quadrants (<em>P</em> &gt; 0.05). In addition, Inner ReT and RNFLT show an upward trend (<em>P</em> &gt; 0.05). PA was significantly increased in the overall retina, Inner retina, superficial capillary plexus (SCP), and middle capillary plexus (ICP) (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The systemic adaptive changes due to high altitude exposure may cause varying degrees of structural and functional changes in the fundus. The current findings require large-scale longitudinal studies to obtain more definitive data on this topic.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104542"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large primary macular holes treated with internal limiting membrane peeling: A literature review","authors":"Wai Yan Lam ,&nbsp;Sunny Chi Lik Au","doi":"10.1016/j.pdpdt.2025.104540","DOIUrl":"10.1016/j.pdpdt.2025.104540","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104540"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro efficacy of photodynamic therapy with toluidine blue for decontamination of resorbable membranes inoculated with Streptococcus mutans","authors":"Ardavan Etemadi ,&nbsp;Sepideh Zonoozi ,&nbsp;Maryam Shad ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2025.104537","DOIUrl":"10.1016/j.pdpdt.2025.104537","url":null,"abstract":"<div><h3>Objectives</h3><div>This study assessed the efficacy of antimicrobial photodynamic therapy (aPDT) with toluidine blue (TB) for decontamination of resorbable membranes inoculated with <em>Streptococcus mutans (S. mutans).</em></div></div><div><h3>Materials and Methods</h3><div>In this <em>in vitro</em> study, Mucoderm and Jason resorbable membranes were cut into 15 pieces each, and were inoculated with <em>S. mutans</em> at 10⁵ colony forming units (CFUs)/mL concentration. The membranes were subsequently assigned to 3 subgroups each (<em>n</em> = 5), for decontamination with TB (100 µg/mL) activated by 635 nm laser (60 s) as the experimental group (aPDT), 0.12 % chlorhexidine (CHX) as the positive control, and phosphate buffered saline (PBS) as the negative control. Changes in colony count after the interventions were calculated. Data were analyzed by the Kruskal-Wallis and Dunn's tests (alpha=0.05).</div></div><div><h3>Results</h3><div>In both membrane types, the difference in colony count was significant among the three subgroups (<em>P</em> = 0.002). The lowest colony count was noted in the CHX subgroup, and the highest was recorded in the PBS subgroup. aPDT caused a significant reduction in colony count compared with the negative control group (<em>P</em> = 0.002). Significant differences were found between all three groups in pairwise comparisons (<em>P</em> &lt; 0.05). The efficacy of aPDT was not significantly different for decontamination of the two membrane types (<em>P</em> = 635).</div></div><div><h3>Conclusion</h3><div>aPDT with 635 nm diode laser and TB had optimal efficacy (although inferior to CHX) for decontamination of both Jason and Mucoderm resorbable membranes inoculated with <em>S. mutans</em>.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"53 ","pages":"Article 104537"},"PeriodicalIF":3.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of the effects of photodynamic therapy on the brain: A review of the literature","authors":"Paweł Woźnicki ,&nbsp;Dorota Bartusik-Aebisher ,&nbsp;Agnieszka Przygórzewska ,&nbsp;David Aebisher","doi":"10.1016/j.pdpdt.2025.104536","DOIUrl":"10.1016/j.pdpdt.2025.104536","url":null,"abstract":"<div><div>Malignant gliomas are the most common primary brain tumors in adults. These tumors have a diverse molecular origin and a very poor prognosis. There is a lack of effective treatment at WHO grade IV glioma, and all glioblastomas progress or recur. Current treatments including surgical intervention, radiation therapy, and chemotherapy are insufficient and can cause damage to healthy brain tissue and neurological deficits. The preservation of healthy brain tissue during therapeutic intervention is made extremely difficult by the ability of malignant gliomas to diffusely infiltrate the surrounding brain parenchyma. Photodynamic therapy (PDT) is a treatment modality for glioma that can possibly overcome the inherent shortcommings of traditional therapies. Photodynamic therapy involves the use of a photosensitizer (PS) which, upon absorption of light by photosensitized tissue, triggers photochemical reactions generating reactive oxygen species (ROS) leading to the killing of tumor cells. Research focusing on the effective use of PDT in the treatment of glioma is already underway with promising results. Clinical studies on PDT for the treatment of gliomas have shown it to be a safe therapeutic modality with acceptable levels of side effects. However, some adverse sequelae have been observed during PDT of these tumours, such as increased photosensitivity, increased intracranial pressure or transient aphasia and worsening of pre-existing neurological deficits. Although the clinical sequelae of PDT are well described, the molecular mechanisms of PDT's effects on the healthy brain have not yet been thoroughly characterized. In our work, we attempt to summarize the molecular mechanisms of the effects of photosensitization on neural tissue, brain vasculature and the blood-brain barrier (BBB). We also point to findings presenting molecular approaches to protect the healthy brain from the adverse effects of photodynamic damage.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104536"},"PeriodicalIF":3.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}