Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment","authors":"Hanhan Chen ,&nbsp;Honglin Li ,&nbsp;Huijie Li ,&nbsp;Zhen Zhang","doi":"10.1016/j.pdpdt.2025.104472","DOIUrl":"10.1016/j.pdpdt.2025.104472","url":null,"abstract":"<div><h3>Background</h3><div>Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma.</div></div><div><h3>Objective</h3><div>To systematically evaluate the existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality and strength while performing updated meta-analyses to refine survival outcomes.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to September 18, 2024, to identify meta-analyses and clinical studies on PDT in patients with cholangiocarcinoma. The random-effects model was employed to re-synthesize existing meta-analyses, with a comprehensive evaluation of methodological quality. Updated meta-analyses of survival data were conducted, including subgroup analyses stratified by cholangiocarcinoma type and intervention modality.</div></div><div><h3>Results</h3><div>A total of 5 meta-analyses and 21 clinical studies were included. The findings indicated that combining PDT with stenting or chemotherapy can significantly improve overall survival in patients with cholangiocarcinoma and reduce mortality rate, without increasing the risk of adverse events (AEs) such as cholangitis or abscess formation. For extrahepatic cholangiocarcinoma, adding PDT to stenting demonstrated a notable improvement in the 2-year survival rate. Meanwhile, for hilar cholangiocarcinoma, the addition of chemotherapy to PDT showed a more pronounced enhancement in the 1-year survival rate.</div></div><div><h3>Conclusion</h3><div>Current evidence indicates that PDT combined with stenting or chemotherapy in the palliative treatment of cholangiocarcinoma decreases overall mortality and enhances OS without increasing the incidence of AEs. Adding PDT to stenting or chemotherapy may be more beneficial for long-term efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104472"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical riboflavin versus 5-aminolevulinic acid photodynamic therapy for the treatment of mild to moderate acne: A split-face randomized study","authors":"Aijia Ding ,&nbsp;Li Shi ,&nbsp;Feng Jiang ,&nbsp;Chong Wang ,&nbsp;Jianglin Zhang","doi":"10.1016/j.pdpdt.2024.104449","DOIUrl":"10.1016/j.pdpdt.2024.104449","url":null,"abstract":"<div><h3>Background</h3><div>ALA-PDT has been widely used in mild to moderate acne vulgaris worldwide. However, very few studies used riboflavin-PDT to treat acne vulgaris.</div></div><div><h3>Objective</h3><div>To investigate the efficacy and adverse events of riboflavin-PDT to treat mild to moderate facial acne, and compare it with ALA-PDT on a non-inferiority basis.</div></div><div><h3>Methods</h3><div>33 eligible patients were enrolled, and 30 patients completed follow-up. Either side of the face was assigned randomly to riboflavin or ALA blue-light-PDT. Patients received 3 sessions of PDT in 1-week intervals and were followed up at weeks 4, 6, and 10.</div></div><div><h3>Results</h3><div>Both ALA and riboflavin-PDT significantly reduced non-inflammatory and inflammatory lesions at weeks 4, 6, and 10 compared to baseline (P all &lt;0.001). For the primary outcome, the difference in the improvement rate of total lesions between the Ribo and ALA side was 2.6 % (-4.3 %, 12.5 %; <em>p</em> = 0.71), which didn't reach the inferiority margin. Patients described greater in-treatment pain and burning sensation (<em>P</em> &lt; 0.001), more prominent post-treatment erythema (<em>P</em> = 0.003), hyperpigmentation (<em>P</em> &lt; 0.001), and desquamation (<em>P</em> = 0.006) on the ALA side than on riboflavin side.</div></div><div><h3>Conclusion</h3><div>The efficacy of riboflavin-PDT was comparable to that of blue-light ALA-PDT in treating mild to moderate acne vulgaris. Riboflavin-PDT had fewer in-treatment and post-treatment adverse events than ALA-PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104449"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal vascular parameters in ocular rosacea patients","authors":"Mariagrazia Avella,&nbsp;Isabella Pellegrino","doi":"10.1016/j.pdpdt.2024.104468","DOIUrl":"10.1016/j.pdpdt.2024.104468","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104468"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photodynamic therapy on vaginal intraepithelial neoplasia grade one: A retrospective cohort study","authors":"Yao Yang ,&nbsp;Dan Cao ,&nbsp;Yi Chen,&nbsp;Ying Xu,&nbsp;Zhenhong Xiong,&nbsp;Zhengrong Zhang,&nbsp;Dan Wu","doi":"10.1016/j.pdpdt.2025.104486","DOIUrl":"10.1016/j.pdpdt.2025.104486","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of photodynamic therapy (PDT) for vaginal intraepithelial neoplasia grade 1 (VaIN1) related to high-risk (Hr)-human papillomavirus (HPV).</div></div><div><h3>Methods</h3><div>Participants aged 25–65 years treated for VaIN1 between March 2022 and September 2022 were retrospectively analyzed into three groups. The PDT and follow-up groups were matched 1:1 for gravidity, HPV type, and quadrants involved. The PDT and CO₂ laser groups were compared without matching. Patients were followed up at 6, 12, and 24 months.</div></div><div><h3>Results</h3><div>After matched, the lesion and Hr-HPV clearance rates of the PDT group (89.5%, 89.5%, 92.1%, and 81.6%, 84.2%, 89.5%) were significantly higher than those of the follow-up group (31.6%, 50.0%, 63.2%, and 21.1%, 26.3%, 31.6%, <em>P</em> &lt; 0.05) at 6, 12, and 24 months. But the lesion clearance rates did not differ significantly between the PDT (68.9%, 82.2%, and 91.1%) and CO₂ laser groups (68.7%, 78.3%, and 85.5%, <em>P</em> &gt; 0.05) at 6, 12, and 24 months, and so did Hr-HPV clearance rates (PDT as 62.2% and 77.8%, and CO₂ laser 54.2% and 61.4%, respectively, <em>P</em> &gt; 0.05) at 6 and 12 months. However, at 24 months, the Hr-HPV clearance rate was higher in the PDT group than in the CO₂ laser group (86.7% vs 71.1%, <em>P</em> = 0.047). In the PDT group, none of the lesions progressed.</div></div><div><h3>Conclusions</h3><div>Compared with CO₂ laser, PDT resulted in a higher Hr-HPV clearance, as well as a low risk of complications and disease progression. PDT is an effective and noninvasive treatment for VaIN1.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104486"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘Photodynamic therapy light’: An enhanced treatment protocol for actinic keratoses with minimal pain and optimal clinical outcome by combining laser-assisted low irradiance PDT with shortened daylight PDT","authors":"Martin T. Braun ,&nbsp;Kelly Del Tredici ,&nbsp;Anna Wölling ,&nbsp;Luitgard Wiest","doi":"10.1016/j.pdpdt.2024.104372","DOIUrl":"10.1016/j.pdpdt.2024.104372","url":null,"abstract":"<div><h3>Background</h3><div>Between 2003 and 2016, 546 patients in our clinic discontinued outpatient treatment for actinic keratoses (AKs) using conventional photodynamic therapy (PDT) because of intolerable pain, thereby necessitating the use of a less painful procedure. Therefore, we developed a novel off-label PDT protocol: ‘PDT light’.</div></div><div><h3>Methods</h3><div>Laser-assisted low irradiance PDT (li-PDT) was performed beginning in 2014. The dosage was gradually lowered to 8–12 <em>J</em>/cm² in 2018, so that we achieved considerable pain reduction while maintaining comparable therapeutic efficacy. A further considerable reduction in pain was achieved from 2018 onwards by combining the advantages of li-PDT with daylight PDT (DLPDT), thereby resulting in 2018 in the new technique ‘PDT light’. Patients with AK Olsen grades 1 or 2 and field cancerization initially received a mild-fractionated CO2 laser pretreatment prior to MAL-incubation (methyl aminolaevulinate, Metvix ®) under occlusion for 1.5–3 h. Then, patients were illuminated on average for 1.02 min with the Aktilite-LED and, after application of an UV-screen on the illuminated area, sent out into daylight for 1 h.</div></div><div><h3>Results</h3><div>Between March and November 2019, we successfully treated 152 cases using the enhanced ‘PDT light’ procedure, with 137 cases achieving at follow-up 1 (on average after 8.14 months) good-to-excellent clearance rates (CLA and CLB together 90 %) and minimal adverse effects.</div></div><div><h3>Conclusions</h3><div>The novel ‘PDT light’ protocol proved to be an excellent and nearly painless method with an average visual-analogue scale (VAS) score of 1.19. Additional advantages included reduced illumination time, shorter outpatient stays in the clinic, fewer adverse effects, and better patient compliance than with DLPDT alone.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104372"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and gender-related changes in choroidal thickness: Insights from deep learning analysis of swept-source OCT images","authors":"Dan Song ,&nbsp;Guanzheng Wang ,&nbsp;Guangfeng Liu ,&nbsp;Chengxia Zhang ,&nbsp;Bin Lv ,&nbsp;Yuan Ni ,&nbsp;Guotong Xie","doi":"10.1016/j.pdpdt.2025.104511","DOIUrl":"10.1016/j.pdpdt.2025.104511","url":null,"abstract":"<div><h3>Background</h3><div>The choroid is a vital vascular layer of the eye, essential for maintaining ocular health. Understanding its structural variations, particularly choroidal thickness (CT), is crucial for the early detection of diseases, such as age-related macular degeneration (AMD), high myopia (HM), and diabetes mellitus (DM). Recent advancements in deep learning have significantly improved the segmentation and measurement of choroidal layers.</div></div><div><h3>Objective</h3><div>This study aims to investigate age- and gender-related changes in CT and its components through deep learning analysis of swept-source optical coherence tomography (SS-OCT) images.</div></div><div><h3>Methods</h3><div>A total of 262 participants (136 females and 126 males) were recruited from Peking University International Hospital. Exclusion criteria included ocular pathologies and systemic conditions. SS-OCT was utilized for CT, Sattler layer-choriocapillaris complex thickness (SLCCT), and Haller layer thickness (HLT) measurements. auto-measurement method, based on deep learning algorithms, ensured accuracy. Ethics approval and informed consent were obtained from all participants.</div></div><div><h3>Findings</h3><div>Significant thinning of CT and SLCCT was observed after the age of 60, with HLT declining after the age of 30. Females exhibited marked thinning between the ages of 40 and 50, while males began to show thinning at age 60.</div></div><div><h3>Conclusion and Implications</h3><div>This research highlights age-related changes in choroidal thickness, with a particular emphasis on gender differences. The findings suggest that females experience earlier thinning, potentially attributable to hormonal changes. Additionally, the study validates the efficiency of deep learning algorithms in measuring choroidal thickness, thereby enhancing the reliability of clinical practice.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104511"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes","authors":"Yuanyuan Liu ,&nbsp;Xueli Yang ,&nbsp;Wei Zhou,&nbsp;Jinguo Yu,&nbsp;Song Chen,&nbsp;Tiangeng He,&nbsp;Caiyun You,&nbsp;Xiangda Meng,&nbsp;Mengyu Liao,&nbsp;Yi Lei,&nbsp;Hua Yan","doi":"10.1016/j.pdpdt.2024.104458","DOIUrl":"10.1016/j.pdpdt.2024.104458","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the association between photoreceptor structural restoration and visual function outcomes in patients undergoing surgery for closed macular holes (MHs). Using adaptive optics scanning laser ophthalmoscopy (AOSLO) and microperimetry, we aimed to provide a more detailed understanding of photoreceptor recovery and visual improvement in closed MHs.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study of 31 eyes of 28 patients who underwent vitrectomy with internal limiting membrane (ILM) peeling to treat idiopathic MHs. Visual and structural outcomes were monitored 3 months to 2 years postoperatively: best-corrected visual acuity (BCVA), MH diameter and duration, optical coherence tomography (OCT) images, 4° retinal mean sensitivity (RMS), fixation rates, 68.2 % BCEA (binary contour ellipse area) of microperimetry, and cone density as measured by AOSLO. Based on the OCT findings, the patients were categorized into two groups: type 1 (closed MH with no neurosensory defect at the fovea) and type 2 (closed MH with a foveal neurosensory defect).</div></div><div><h3>Results</h3><div>The analysis revealed that type 1 closures resulted in significantly better photoreceptor recovery, with cone cells migrating toward the fovea and forming dense islets, consistent with the integrity of the inner segment/outer segment layer on OCT. These patients also had better postoperative BCVA and higher RMS rather than fixation improvement, aligning with the improved cone density. In contrast, type 2 closures exhibited sparse cone distribution and a prevalence of large, high-density cells, possibly indicating glial cell proliferation and exposed retinal pigment epithelium (RPE). MH size, rather than duration or preoperative BCVA, was a key determinant of type 1 closure outcomes.</div></div><div><h3>Conclusion</h3><div>AOSLO is a valuable tool for evaluating microstructural healing in MHs and reveals that type 1 closure, characterized by cone migration, leads to greater neuroretinal repair and improved BCVA and retinal sensitivity. Meanwhile, type 2 closures, marked by less photoreceptor recovery and higher glial proliferation, correspond to poorer visual function outcomes. This study highlights the role of photoreceptor density and migration in achieving optimal visual function post-surgery for MH closure.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104458"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy","authors":"Yuqing Wang ,&nbsp;Yiting Xu ,&nbsp;Yong Qu ,&nbsp;Yifang Jin ,&nbsp;Juanmei Cao ,&nbsp;Jinshan Zhan ,&nbsp;Zhuoxia Li ,&nbsp;Chuxing Chai ,&nbsp;Changzheng Huang ,&nbsp;Min Li","doi":"10.1016/j.pdpdt.2024.104463","DOIUrl":"10.1016/j.pdpdt.2024.104463","url":null,"abstract":"<div><div>Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent additional strategies for tumor treatment. Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. Ferroptosis, an iron-dependent type of programmed cell death characterized by accumulation of reactive oxygen species and lipid peroxidation products to lethal levels, has emerged as an attractive target trigger for tumor therapies. Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104463"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anterior chamber depth measured by three different anterior segment analysis systems","authors":"Han Song ,&nbsp;Wei Yang ,&nbsp;Chunliu Yang ,&nbsp;Qing Sun","doi":"10.1016/j.pdpdt.2025.104471","DOIUrl":"10.1016/j.pdpdt.2025.104471","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to compare and evaluate the correlation and agreement among three distinct anterior segment analysis systems in measuring anterior chamber depth (ACD) in healthy myopic individuals.</div></div><div><h3>Methods</h3><div>Myopic patients who underwent preoperative assessments at our hospital's refractive surgery department from January 2021 to December 2023 were included in this investigation. ACD was measured using three anterior segment analysis systems: Pentacam, Sirius, and IOLMaster 700. Statistical analyses were performed using SPSS software. The Pearson method was utilized to analyze correlations between the measured values of the three groups. Bland-Altman scatter plots were generated using MedCalc software, with 95 % limits of agreement applied to assess consistency among the datasets.</div></div><div><h3>Results</h3><div>The mean anterior chamber depth (ACD) measured by the Pentacam, Sirius, and IOLMaster 700 was found to be 3.26 ± 0.26 mm, 3.30 ± 0.26 mm and 3.22 ± 0.25 mm, respectively. The mean ACD values obtained from these three devices exhibited statistically significant differences (<em>p</em> &lt; 0.05). Furthermore, the ACD measurements from all three devices demonstrated a strong positive correlation with each other, <em>p</em> &lt; 0.001, <em>r</em> = 0.965 (Pentacam and Sirius), <em>r</em> = 0.955 (Pentacam and IOLMaster 700), and <em>r</em> = 0.966 (Sirius and IOLMaster 700). The respective 95 % LoAs were -1.16 ∼ -0.73(Pentacam and Sirius);0.55 ∼ 1.05(Pentacam and IOLMaster 700);1.53 ∼ 1.96 (Sirius and IOLMaster 700).</div></div><div><h3>Conclusion</h3><div>There is a high positive correlation between the anterior chamber depth (ACD) measured by three different anterior segment analysis systems in healthy myopic eyes. However, the differences in the measurement of different optical devices should be considered in clinical work, and it is not recommended to interchange them.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104471"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience","authors":"Gennady Meerovich ,&nbsp;Evgeniya Kogan ,&nbsp;Igor Romanishkin ,&nbsp;Nikolay Zharkov ,&nbsp;Sofiya Avraamova ,&nbsp;Elena Shchelokova ,&nbsp;Ekaterina Akhlyustina ,&nbsp;Marina Strakhovskaya ,&nbsp;Irina Meerovich ,&nbsp;Sofya Demura ,&nbsp;Irina Tiganova ,&nbsp;Yulia Romanova ,&nbsp;Zhi-Long Chen ,&nbsp;Igor Reshetov","doi":"10.1016/j.pdpdt.2024.104447","DOIUrl":"10.1016/j.pdpdt.2024.104447","url":null,"abstract":"<div><div>The problem of treating cancer patients with lung cancer has become more difficult due to the SARS-CoV-2 viral infection and concomitant bacterial lesions. The analysis shows that the photodynamic effect of long-wavelength polycationic photosensitizers suppresses the tumor process (including the destruction of cancer stem cells), SARS-CoV-2 coronavirus infection, Gram-positive and Gram-negative bacteria, including those that can cause pneumonia. Therefore, the photodynamic approach using such photosensitizers is promising for the development of an effective treatment method for patients with lung cancer, including those with SARS-CoV-2 infection and bacterial complications.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104447"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}