Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Evaluation of the lamina cribrosa after topical latanoprost therapy in primary open-angle glaucoma or ocular hypertension","authors":"Zeynep Duru ,&nbsp;Medine Gündoğan ,&nbsp;İbrahim Sert ,&nbsp;Numan Işın ,&nbsp;Mustafa Ataş ,&nbsp;Ender Sırakaya","doi":"10.1016/j.pdpdt.2024.104257","DOIUrl":"10.1016/j.pdpdt.2024.104257","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate that the changes of lamina cribrosa (LC) thickness and depth after latanoprost therapy in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) patients.</p></div><div><h3>Methods</h3><p>In this single-center prospective cross-sectional study, 35 eyes from 35 patients with POAG or OHT (study group) and 26 age- and gender- matched healthy individuals (control group) were included. All participants were examined by spectral domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode for LC thickness and depth measurements at the first visit before latanoprost therapy and at visits after 1 (second visit) and 3 (third visit) months of latanoprost therapy.</p></div><div><h3>Results</h3><p>The mean LC thickness in both horizontal and vertical scans of the study group were thinner than the control group (<em>p</em> &lt; 0.001, for both). During latanoprost therapy in the study group, the LC thickness values in horizontal scans significantly differed over the three visits, gradually increased (<em>p</em> &lt; 0.05). There was significantly decrease in LC depth in horizontal scans between the first and third visits, and the second and third visits (<em>p</em> = 0.003 and <em>p</em> = 0.008, respectively). The gradual decrease in LC depth in vertical scans was observed at all visits, but the statistically significant difference was between the first and third visits only (<em>p</em> = 0.048).</p></div><div><h3>Conclusion</h3><p>POAG/OHT patients showed more LC thinning compared with healthy individuals. The significant increase in LC thickness and the significant decrease in LC depth were detected after IOP reduction therapy with latanoprost in ocular hypertensive/ glaucomatous eyes.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002941/pdfft?md5=c9d220e4d164e3c4169bd837a6e07be1&pid=1-s2.0-S1572100024002941-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of photobiomodulation on osseointegration in dental implants: A systematic review and meta-analysis","authors":"Ravinder S Saini ,&nbsp;Masroor Ahmed Kanji ,&nbsp;Abdulmajeed Okshah ,&nbsp;Abdulkhaliq Ali F Alshadidi ,&nbsp;Rayan Ibrahim H Binduhayyim ,&nbsp;Rajesh Vyas ,&nbsp;Lujain Ibrahim N Aldosari ,&nbsp;Anna Vardanyan ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.pdpdt.2024.104256","DOIUrl":"10.1016/j.pdpdt.2024.104256","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to assess the effectiveness of photobiomodulation therapy (PBM) in enhancing bone integration with dental implants.</p></div><div><h3>Method</h3><p>PubMed, ScienceDirect, the Cochrane Library, Scopus, and Google Scholar were searched. Studies assessing PBM effectiveness with defined intervention/control groups were included, while those lacking specified laser types, involving severe maxillofacial defects or surgery, and not reporting outcomes related to dental implant osseointegration post-PBM therapy were excluded. The studies' risk of bias was assessed using Robvis for randomized controlled trials (RCTs) and ROBINS-I for non-RCTs. The meta-analysis was conducted utilizing a random-effects model at a significance level of 0.01.</p></div><div><h3>Results</h3><p>The study reviewed 26 papers involving 571 patients undergoing dental implant procedures with PBM/Low-Level Laser Therapy (LLLT) or placebo/control. Implant stability quotients (ISQ) analysis showed a non-significant difference (<em>p</em> = 0.06, mean difference: 1.02, 95 % CI: 0.28 to 1.75, <em>I²</em>=28 %), while the Periotest method indicated significant improvement in stability (<em>p</em> &lt; 0.01, mean difference: -0.51, 95 % CI: -0.78 to -0.24, <em>I²</em>=71 %). PBM resulted in a significant bone density increase (<em>p</em> &lt; 0.01, mean difference: 26, 95 % CI: 6.93 to 45.06, <em>I²</em>=91 %), but marginal bone loss showed no significant difference (<em>p</em> = 0.11, mean difference: 0.00, 95 % CI: -0.06 to 0.05, <em>I²</em>=45 %). Implant survival rate did not significantly differ (<em>p</em> = 0.73, mean difference: 1.56, 95 % CI: 0.38 to 6.46, <em>I²</em>=0 %). Most studies raised concerns regarding randomization.</p></div><div><h3>Conclusion</h3><p>PBM could improve implant stability, as assessed with Periotest, and increase bone density, enhancing osseointegration. However, implant stability assessed with ISQ, marginal bone loss, and implant survival rate were comparable between the study groups.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S157210002400293X/pdfft?md5=976bc27a7777403be492e932359ecbba&pid=1-s2.0-S157210002400293X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PDD-TURBT alone versus white light TURBT plus intravesical BCG therapy: A propensity-score matching study","authors":"Jimpei Miyakawa ,&nbsp;Yuta Yamada ,&nbsp;Yuji Hakozaki ,&nbsp;Katsuhiro Makino ,&nbsp;Jun Kamei ,&nbsp;Satoru Taguchi ,&nbsp;Taketo Kawai ,&nbsp;Yoshiyuki Akiyama ,&nbsp;Daisuke Yamada ,&nbsp;Haruki Kume","doi":"10.1016/j.pdpdt.2024.104254","DOIUrl":"10.1016/j.pdpdt.2024.104254","url":null,"abstract":"<div><h3>Background</h3><p>Although photodynamic-diagnosed transurethral resection of bladder cancer (PDD-TURBT) and Bacillus Calmette-Guérin (BCG) intravesical instillation are the two representative therapies for non-muscle invasive bladder cancer (NMIBC), no studies directly compare their efficacy. We evaluated the outcome of PDD-TURBT alone compared with white light TURBT with intravesical BCG therapy and analyzed the efficacy of both therapies depending on the characteristics of the tumors.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed intermediate- and high-risk NMIBC patients treated with PDD-TURBT alone (the PDD group) or white light TURBT with BCG therapy (the white light group) using propensity score matched analysis.</p></div><div><h3>Results</h3><p>In the propensity score matched cohort, the 1-, 2-, and 3-year recurrence-free survival rates for the PDD group were 77.6 %, 64.1 %, and 48.1 %, respectively, compared to 84.6 %, 75.1 %, and 75.1 % for the white light group (<em>p</em> = 0.44, 0.27, 0.17, respectively). The difference in recurrence rates between the two groups tended to become more pronounced over time, although there was no significant difference. In the univariate and multivariate analysis, recurrence, multiplicity, and tumor grade were the significant prognostic factors of recurrence in the PDD group (<em>p</em> = 0.010, 0.047, 0.048, respectively). Long-term RFS was similar in the PDD and white light groups when the population was limited to the primary and single tumors, suggesting that PDD-TURBT alone may be sufficient in this spectrum of patients.</p></div><div><h3>Conclusions</h3><p>PDD-TURBT alone is insufficient to control the long-term recurrence of bladder cancer but can be effective in selected cases such as primary and single tumors.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002916/pdfft?md5=38828f5ba76f96d9ed00f7a17b8a278d&pid=1-s2.0-S1572100024002916-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemin enhances the 5-aminolevulinic acid-photodynamic therapy effect through the changes of cellular iron homeostasis","authors":"Anantya Pustimbara,&nbsp;Chenhan Li,&nbsp;Shun-ichiro Ogura","doi":"10.1016/j.pdpdt.2024.104253","DOIUrl":"10.1016/j.pdpdt.2024.104253","url":null,"abstract":"<div><h3>Background</h3><p>Photodynamic therapy (PDT) has been utilized as a promising alternative cancer treatment due to its minimum invasiveness over the years. Exogenous 5-aminolevulinic acid (ALA) triggers protoporphyrin IX (PpIX) accumulation, which happens in cancer cells. However, certain types of cancer exhibit reduced effectiveness in the PpIX accumulation mechanism. This study aimed to determine the effect of ALA-PDT combination with hemin on gastric carcinoma TMK-1 cells.</p></div><div><h3>Methods</h3><p>This study utilized TMK-1 gastric cancer cell line to evaluate PpIX, ROS, and Fe²⁺ accumulation following the administration of ALA, hemin, and a combination of ALA and hemin PDT. We also evaluate the mRNA expressions related to iron homeostasis and treatment impacts on cell viability.</p></div><div><h3>Results</h3><p>The co-addition of ALA and hemin PDT for 4 h of treatment resulted in a significant decrease in cell viability by up to 18 %. While ALA-PDT enhanced PpIX metabolism, the addition of hemin influenced both the production of reactive oxygen species (ROS) and cellular iron homeostasis by inducing Fe²⁺ accumulation and affecting mRNA levels of <em>IRP, Tfr1, Ferritin, NFS1,</em> and <em>SDHB.</em></p></div><div><h3>Conclusion</h3><p>These findings suggest that the addition of ALA and hemin enhances phototoxicity in TMK-1 cells. The combination of ALA and hemin with PDT induces cell death, evidenced by increased cytotoxicity properties such as PpIX and ROS, along with significant changes in TMK-1 gastric cancer iron homeostasis. Therefore, the combination of ALA and hemin could be one of the alternatives in photodynamic therapy for cancer in the future.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002904/pdfft?md5=a72a80d2b3398fb2d881bd8561b76884&pid=1-s2.0-S1572100024002904-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium iodide enhances the killing effect of methylene blue mediated photodynamic therapy against F. monophora","authors":"Qian Li ,&nbsp;Yinghui Liu ,&nbsp;Jinjin Zheng ,&nbsp;Yangxia Chen ,&nbsp;Zeyu Liu ,&nbsp;Qiulin Xie ,&nbsp;Dongmei Li ,&nbsp;Liyan Xi ,&nbsp;Judun Zheng ,&nbsp;Hongfang Liu","doi":"10.1016/j.pdpdt.2024.104255","DOIUrl":"10.1016/j.pdpdt.2024.104255","url":null,"abstract":"<div><h3>Background</h3><p>Chromoblastomycosis (CMB) is a chronic granulomatous fungal infection that affect the skin and subcutaneous tissues. It is clinically problematic due to limited treatment options, low cure rates, and high rates of relapse. This underscores the necessity for innovative treatment approaches. In this study, potassium iodide (KI) combined with Methylene Blue (MB) mediated antimicrobial photodynamic therapy (PDT) were assessed in the treatment of <em>Fonsecaea monophora (F. monophora)</em> both <em>in vitro</em> and <em>in vivo</em>. And the underlying mechanism that contributes to the efficacy of this treatment approach was investigated.</p></div><div><h3>Methods</h3><p><em>In vitro</em> experiments were conducted using different combinations and concentrations of MB, KI, and 660 nm light (60 mW/cm²) to inhibit <em>F. monophora</em>. The study was carried out using colony-forming unit (CFU) counts and scanning electron microscopy (SEM). The production of singlet oxygen (¹O₂), free iodine (I₂), hydrogen peroxide (H₂O₂), and superoxide anion during the KI combined MB-mediated antimicrobial PDT process was also detected. <em>In vivo</em> experiments were developed using a Balb/c mouse paw infection model with <em>F. monophora</em> and treated with PBS, 10 mM KI, 2 mM MB +100 J/cm² and 10 mM KI+2 mM MB +100 J/cm² respectively. Inflammatory swelling, fungal load and histopathological analyses of the mouse footpads were assessed.</p></div><div><h3>Results</h3><p>KI enhanced the killing effect of MB-mediated antimicrobial PDT on the conidial spores of <em>F. monophora</em> at the cell and infected animal model level. During the process, the main antimicrobial agents in KI combined with MB- mediated antimicrobial PDT could produce stronger toxic active species including free I₂ and H₂O_2.</p></div><div><h3>Conclusion</h3><p>KI combined with MB-mediated antimicrobial PDT could be an effective adjunct therapy for treating CBM.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002928/pdfft?md5=e607f6dc3f1a70cd395b065919e9354c&pid=1-s2.0-S1572100024002928-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis and characterization of AgNPs, liposomal loaded AgNPs and ZnPcS4 photosensitizer for enhanced photodynamic therapy effects in MCF-7 breast cancer cells","authors":"Alexander Chota,&nbsp;Heidi Abrahamse,&nbsp;Blassan P. George","doi":"10.1016/j.pdpdt.2024.104252","DOIUrl":"10.1016/j.pdpdt.2024.104252","url":null,"abstract":"<div><p>Breast cancer remains a formidable challenge in oncology despite significant advancements in treatment modalities. Conventional therapies such as surgery, chemotherapy, radiation therapy, and hormonal therapy have been the mainstay in managing breast cancer for decades. However, a subset of patient's experiences treatment failure, leading to disease recurrence and progression. Therefore, this study investigates the therapeutic potential of green-synthesized silver nanoparticles (AgNPs) using an African medicinal plant (<em>Dicoma anomala</em> methanol root extract) as a reducing agent for combating breast cancer. AgNPs were synthesized using the bottom-up approach and later modified with liposomes (Lip) loaded with photosensitizer (PS) zinc phthalocyanine tetrasulfonate (Lip@ZnPcS₄) using thin film hydration method. The successful formation and Lip modification of AgNPs, alongside ZnPcS₄, were confirmed through various analytical techniques including UV–Vis spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). Following a 24 h treatment period, MCF-7 cells were assessed for viability using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT viability assay), cell death analysis using mitochondrial membrane potential (MMP) (Δ<em>Ψm</em>), Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) kit, and caspase- 3, 8 and 9 activities. The experiments were repeated four times (<em>n</em> = 4), and the results were analyzed using SPSS statistical software version 27, with a confidence interval set at 0.95. The synthesized nanoparticles and nanocomplex, including AgNPs, AgNPs-Lip, Lip@ZnPcS₄, and AgNPs-Lip@ZnPcS₄, exhibited notable cytotoxicity and therapeutic efficacy against MCF-7 breast cancer cells. Notably, the induction of apoptosis, governed by the upregulation of apoptotic proteins i.e., caspase 8 and 9 activities. In addition, caspase 3 was not expressed by MCF-7 cells in both control and experimental groups. Given the challenging prognosis associated with breast cancer, the findings underscore the promise of liposomal nanoformulations in cancer photodynamic therapy (PDT), thus warranting further exploration in clinical settings.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002898/pdfft?md5=7a7108178e9e896a2a04379e76be2d70&pid=1-s2.0-S1572100024002898-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral cancer detection and diagnosis: A promising future with quantum dots","authors":"Vijayaraj Venkatachalam,&nbsp;Deepankumar Shanmugamprema,&nbsp;Muthaiah Shellaiah,&nbsp;Sandeep Eswaran Panchu","doi":"10.1016/j.pdpdt.2024.104251","DOIUrl":"10.1016/j.pdpdt.2024.104251","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002886/pdfft?md5=048305da254c8f69e7fa2e69fad54f89&pid=1-s2.0-S1572100024002886-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photodynamic therapy with two photosensitizers on the microtensile bond strength of a universal adhesive to affected dentin","authors":"Sedighe Sadat Hashemikamangar ,&nbsp;Pardis Biglari ,&nbsp;Zahra Shahidi ,&nbsp;Nasim Chiniforush","doi":"10.1016/j.pdpdt.2024.104249","DOIUrl":"10.1016/j.pdpdt.2024.104249","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to evaluate the impact of photodynamic therapy (PDT) using two photosensitizers, methylene blue and indocyanine green, on the microtensile bond strength of a universal adhesive to caries-affected dentin.</p></div><div><h3>Methods</h3><p>The occlusal enamel of 60 third molars was cut to expose the inner one-third of the dentin. Artificial caries were induced through a pH cycling process. The samples were divided into three groups: M (Methylene blue+ diode laser), I (Indocyanine green agents+ diode laser irradiation), and control. Each group was further divided into two subgroups according to the adhesive protocol (self-etch, total-etch). After restoring with Gradia composite resin, teeth were sectioned and exposed to 5000 thermal cycles. Microtensile bond strength was measured using a universal testing machine. The data were subjected to two- and one-way ANOVA and paired comparisons were performed by the Tamhane and Tukey tests.</p></div><div><h3>Results</h3><p>The study found significant effects of the photosensitizer, etching pattern, and their interactions on the microtensile bond strength of composite resin to caries-affected dentin (<em>P</em> &lt; 0.001). In the self-etching mode, PDT with indocyanine green exhibited significantly higher bond strength values compared to PDT with methylene blue (<em>P</em> = 0.001) and the control groups (<em>P</em> &lt; 0.001). However, no significant differences were observed in the total-etch mode. (<em>P</em> = 0.54).</p></div><div><h3>Conclusions</h3><p>The etching mode played a more significant role in the bond strength when using the universal adhesive alongside PDT with methylene blue and indocyanine green. Employing two photosensitizers in PDT during the self-etch mode significantly increased the bond strength values.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002862/pdfft?md5=238d51d3bb36e50849575ec10480306b&pid=1-s2.0-S1572100024002862-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the therapeutic effects of photodynamic therapy, transpupillary thermotherapy, and their combination on circumscribed choroidal haemangioma","authors":"Yanfang Si ,&nbsp;Ying Li ,&nbsp;Juan Zhao ,&nbsp;Xiaoda Bi ,&nbsp;Qian Shi ,&nbsp;Lei Shi ,&nbsp;Qian Wang ,&nbsp;Ping Zhang","doi":"10.1016/j.pdpdt.2024.104250","DOIUrl":"10.1016/j.pdpdt.2024.104250","url":null,"abstract":"<div><h3>Objective</h3><p>To characterize the clinical and imaging features of circumscribed choroidal hemangioma (CCH), and to evaluate individualized treatment efficiency of photodynamic therapy (PDT), transpupillary thermotherapy (TTT), or their combination, followed by retrobulbar injection of betamethasone on CCH resolvement.</p></div><div><h3>Methods</h3><p>Forty-nine patients with CCHs who underwent PDT, TTT or PDT+TTT treatments were retrospectively analyzed. Their treatment efficacy was compared by analyzing the change of best corrected visual acuity (BCVA), subretinal fluid (SRF) and CCH lesion characteristics.</p></div><div><h3>Results</h3><p>PDT, TTT and PDT+TTT were respectively administrated in 17, 11 and 21 patients. No significant difference in age, gender, affected eyes and tumor location across the three groups. Baseline BCVA were 0.41 ± 0.28, 0.62 ± 0.30 and 0.24 ± 0.24 for PDT, TTT and PDT+TTT groups, respectively (<em>F</em> = 6.572, <em>P</em> = 0.003). CCH treated by three strategies showed significant difference in maximum tumor basal diameter, SRF areas and macula involvement prior to the treatment (<em>P</em> &lt; 0.05). Patients receiving PDT+TTT exhibited larger tumor basal diameter, more SRF, higher ratio of macular involvement than other groups. A total of 38 (77.6 %) cases had good visual acidity with final BCVA ≥0.5 after treatments. PDT and PDT+TTT treatment groups acquired more vision improvement (0.27 ± 0.23 and 0.31 ± 0.26) in BCVA than TTT group (0.09 ± 0.13). All SRF were resolved within two weeks of treatment and no recurrent SRF were found.</p></div><div><h3>Conclusion</h3><p>The three treatments showed good performance in improving visual function and controlling SRF, and individualized treatment should be selected primarily by the tumor location, and then the tumor size and presence of SRF.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002874/pdfft?md5=e4853bce7365304ed0d0ae0c2ff2e64b&pid=1-s2.0-S1572100024002874-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141405274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior segment optical coherence tomography for superficial keratectomy","authors":"Zi-wen Wang ,&nbsp;Xiao-fang Yin ,&nbsp;Chun-xiao Wang ,&nbsp;Hui-zhen Wang ,&nbsp;Shi-you Zhou","doi":"10.1016/j.pdpdt.2024.104237","DOIUrl":"10.1016/j.pdpdt.2024.104237","url":null,"abstract":"<div><h3>Purpose</h3><p>To report the use of anterior segment optical coherence tomography (AS-OCT) for superficial keratectomy (SK) in anterior corneal opacity.</p></div><div><h3>Methods</h3><p>The characteristics of 43 eyes (39 patients) with various lesions responsible for anterior corneal opacity were included in this retrospective non-comparative study. AS-OCT was performed on all eyes before surgery. The thickness of corneal opacity and the underlying healthy stroma were measured. SK was performed on each individual.</p></div><div><h3>Results</h3><p>Four types of anterior corneal opacity were evaluated, including corneal degeneration (26/43), Reis-Bücklers corneal dystrophy (8/43), alkali burn (1/43) and corneal tumors (8/43). Based on AS-OCT images, all eyes showed abnormal hyper-reflective signals in the superficial cornea to less than one-third of the normal corneal thickness in the deepest corneal opacity. All 43 eyes underwent an SK procedure. In addition, 1 eye with alkali burns and 7 eyes with corneal tumors were combined with amniotic membrane transplantation. All eyes restored transparency without significant complications.</p></div><div><h3>Conclusion</h3><p>AS-OCT is a valuable method for objective preoperative and noninvasive assessments of anterior corneal opacities and is useful for guiding SK.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002746/pdfft?md5=09702558e76fce98eabc058ea2993895&pid=1-s2.0-S1572100024002746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}