Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Evaluation of the effect of ocular dominance on macular microcirculation via swept-source optical coherence tomography angiography","authors":"Yalcin Karakucuk ,&nbsp;Serhat Eker","doi":"10.1016/j.pdpdt.2024.104317","DOIUrl":"10.1016/j.pdpdt.2024.104317","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the existence of differences in the retinal microcirculation of dominant and non-dominant eyes, as well as of interocular differences in macular microcirculation, using swept-source optical coherence tomography angiography (OCTA).</p></div><div><h3>Methods</h3><p>In total, 122 eyes of 61 individuals were enrolled in this cross-sectional study. Measurements were taken using the swept-source optical coherence tomography Triton device (Topcon Corp, Tokyo, Japan) coupled with non-invasive OCTA technology. Macular perfusion parameters were assessed, including superficial vascular complex, vascular density of the deep vascular complex, vascular density of the choriocapillaris vascular complex, superficial foveal avascular zone and deep foveal avascular zone. Ocular dominance was determined among individuals with healthy eyes using the hole-in-the-card test.</p></div><div><h3>Results</h3><p>Ocular dominance was found in 68.9 % of right eyes and 31.1 % of left eyes. The mean age of the subjects was 34.45 ± 16.48 years (range: 18–73 years). We found that 16 (30.76 %) males and 22 (31.42 %) females had left-eye dominance (<em>p</em> &gt; 0.05). None of the OCTA parameters differed between the eyes based on dominance (<em>p</em> &gt; 0.05). Central macular thickness and sub-foveal choroidal thickness did not show significant differences (<em>p</em> &gt; 0.05). When comparing interocular parameters, a significant difference was observed only in the inferior sector of the superficial vascular complex (<em>p</em> = 0.04).</p></div><div><h3>Conclusion</h3><p>There was no significant difference in OCTA parameters between dominant and non-dominant eyes. There was no predominant interocular difference in the measurements.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104317"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003545/pdfft?md5=333b2160dc68768fc1a05ab8fe4f4296&pid=1-s2.0-S1572100024003545-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regorafenib enhances the efficacy of photodynamic therapy in hepatocellular carcinoma through MAPK signaling pathway suppression","authors":"Song Zhang ,&nbsp;Xiao Zhang ,&nbsp;Yali Ren ,&nbsp;Lu Huang ,&nbsp;Weitian Xu ,&nbsp;Haiping Wang ,&nbsp;Qiping Lu","doi":"10.1016/j.pdpdt.2024.104319","DOIUrl":"10.1016/j.pdpdt.2024.104319","url":null,"abstract":"<div><p>Photodynamic therapy (PDT) is a promising and innovative approach for treating tumors. The synergistic effect of PDT and chemotherapy can enhance the anti-tumor efficacy by leveraging their complementing benefits. In this study, we created lipid vesicles to deliver a photosensitizer (chlorin e6, Ce6) and Regorafenib into tumors for the purpose of examining the effectiveness and mechanism of Lipo-Ce6@Rego-PDT (LCR-P) on Hepatocellular carcinoma (HCC) both <em>in vitro</em> and <em>in vivo</em>. We found that the cytotoxicity on HCC caused by LCR-P was significantly stronger than that caused by Lipo-Ce6-PDT (LC-P). Cellular ROS production in the LCR-P group was approximately higher than that in the LC-P group, and Regorafenib significantly inhibited the phosphorylation of JNK, ERK, and P38 of Lipo-Ce6-PDT group <em>in vitro</em> and <em>in vivo</em>. Furthermore, Regorafenib significantly downregulated the expression of Bcl-2 and upregulated the expression of Bax and cleaved caspase-3 of LC-P group <em>in vitro</em> and <em>in vivo</em>. Compared with LC-P, LCR-P significantly increased cell apoptosis rate. The body weight and HE staining of normal organs primarily indicated the safety of this combined strategy. These results indicate that the combination of Regorafenib and Lipo-Ce6 can significantly enhance the anti-tumor efficiency of PDT for HCC and exhibits good biosafety.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104319"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003569/pdfft?md5=5c6450b376804776d649a3c80f2607bc&pid=1-s2.0-S1572100024003569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal perfusion related to visual field within the same asymmetric thyroid-associated ophthalmopathy","authors":"Yu Shi ,&nbsp;Weijie Liu ,&nbsp;Xiaozhou Hu ,&nbsp;Yunhai Tu ,&nbsp;Wencan Wu ,&nbsp;Jie Ye","doi":"10.1016/j.pdpdt.2024.104318","DOIUrl":"10.1016/j.pdpdt.2024.104318","url":null,"abstract":"<div><h3>Purpose</h3><p>To quantify interocular differences in the retinal microvasculature between disparate eyes and explore associations between the retinal microvasculature and visual field abnormalities within the same asymmetric thyroid-associated ophthalmopathy (TAO) patients.</p></div><div><h3>Methods</h3><p>Within the same asymmetric TAO eye, the eye with a severer visual field abnormality (based on the mean deviation [MD]) was considered a severe eye, and the fellow eye was considered mild. The densities of radial peripapillary capillary (RPC) and superficial retinal capillary plexuses (SRCP) were determined using optical coherence tomography angiography. Interocular differences in RPC and SRCP densities were analyzed. A generalized estimating equation (GEE) was used to form a predictive model for visual field abnormalities. Pearson's correlation was used to show the correlation between MD and the densities of RPC and SRCP.</p></div><div><h3>Results</h3><p>In 57 asymmetric TAO patients, the global RPC density in severe eyes was lower than that in mild eyes (<em>P</em> &lt; 0.001), but there was no significant difference in SRCP density between the two groups (<em>P</em> = 0.114). In a multivariate GEE model with MD as the outcome, MD was associated only with global RPC density (coefficient β=0.327, <em>P</em> &lt; 0.001). The global RPC density was correlated with MD (<em>r</em> = 0.360, <em>P</em> = 0.003) in severe eyes, but not in mild eyes (<em>r</em> = 0.179, <em>P</em> = 0.092). No significant correlation was observed between global SRCP density and MD in either group (Both <em>P</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>RPC density decreased significantly and correlated with visual field abnormalities in severe eyes of TAO patients. Alterations in RPC density may contribute to visual field abnormalities in TAO eyes.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104318"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003557/pdfft?md5=c7c025a59a614dc21e5b3bc32a753d11&pid=1-s2.0-S1572100024003557-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of photodynamic therapy to combat recurrent pharyngotonsillitis: Three case reports","authors":"Laíza Mohana Pinheiro Duarte ,&nbsp;Isabella Dotta Damha Santiago ,&nbsp;Kate Cristina Blanco ,&nbsp;Vanderlei Salvador Bagnato","doi":"10.1016/j.pdpdt.2024.104312","DOIUrl":"10.1016/j.pdpdt.2024.104312","url":null,"abstract":"<div><h3>Background</h3><div>Pharyngotonsillitis (PT) is an inflammatory and infectious condition affecting the tonsils in the oropharynx, predominantly caused by a variety of viral, fungal, and bacterial pathogens, including <em>Streptococcus pyogenes</em>. With the increasing challenge of antibiotic resistance, alternative therapeutic approaches are needed.</div></div><div><h3>Methods</h3><div>This study explores the effectiveness and safety of Photodynamic Therapy (PDT) as a therapeutic approach for managing acute PT. PDT involves the use of a photosensitizer, light, and molecular oxygen. We utilized a curcumin-based photosensitizer incorporated into a gum formulation, followed by exposure to blue LED irradiation (455 ± 30 nm, intensity of 200 mW for 6 min) with 1 to 2 PDT sessions depending on the clinical case.</div></div><div><h3>Results</h3><div>The treatment's impact was assessed through systematic monitoring of clinical progression post-treatment, encompassing clinical history, examination, and follow-up. In all three cases examined, PDT was observed to effectively eradicate the infection and prevent its recurrence during the period evaluated.</div></div><div><h3>Conclusion</h3><div>Photodynamic Therapy, using a curcumin-based photosensitizer and blue LED light, appears to be a promising alternative to traditional antibiotics for the treatment of PT, demonstrating both efficacy in infection eradication and safety in application. Further studies are recommended to substantiate these findings and explore long-term outcomes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104312"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003491/pdfft?md5=f5a59f48636f9ff5585dfd40de59a582&pid=1-s2.0-S1572100024003491-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case series of low-level laser therapy treatment in patients with peripheral facial palsy","authors":"Javier Basualdo Allende ,&nbsp;Rodrigo Caviedes ,&nbsp;Alfredo von Marttens ,&nbsp;Milton Kuga ,&nbsp;Eduardo Fernández","doi":"10.1016/j.pdpdt.2024.104314","DOIUrl":"10.1016/j.pdpdt.2024.104314","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral Facial Palsy (PFP) is a facial paralysis with various etiologies, including idiopathic causes (Bell's palsy), infections, trauma, and genetic factors. Traditional treatments involve antiviral medications, corticosteroids, and physiotherapy. However, new therapies, such as Low-Level Laser Therapy (LLLT), are emerging with promising results.</p></div><div><h3>Methods</h3><p>This case series reports on two patients with PFP treated with LLLT combined with Vitamin B1, B6, and B12 supplementation. The first case involved a 52-year-old female with PFP due to a viral infection. The second case was a 33-year-old male who developed PFP following a traumatic brain injury. Both patients received LLLT sessions every two weeks, targeting 10 points along the facial nerve pathway from the facial notch across the face. The laser device used was the Theraphy EC (DMC, Sao Carlos, SP, Brazil), with each point receiving 4 Joules of energy applied perpendicular to the skin after cleaning the face with water and soap to remove lipids that could interfere. The administration of Vitamin B was done using NEUROBIONTA tablets (Vitamin B1 + Vitamin B6 + Vitamin B12; Procter &amp; Gamble, Santiago, Chile) with one tablet taken daily for 30 days.</p></div><div><h3>Results</h3><p>After six to seven sessions, both patients showed significant improvement in facial muscle function and overall facial symmetry. In the first case, improvements were noted in muscle tonicity and facial movements, with the patient reporting reduced facial disfigurement. In the second case, notable recovery in facial mobility and symmetry was observed, with the patient experiencing decreased paresthesia and restored muscle functionality.</p></div><div><h3>Conclusion</h3><p>These findings suggest that LLLT, combined with Vitamin B1, B6, and B12 supplementation, may effectively improve facial muscle function and symmetry in PFP patients. The non-invasive nature and ease of application make LLLT a viable option for PFP treatment. Further studies with larger sample sizes and standardized protocols are necessary to confirm these results and establish LLLT as a standard treatment for PFP.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104314"},"PeriodicalIF":3.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S157210002400351X/pdfft?md5=aa8d943233e8959430be2141dfb1a716&pid=1-s2.0-S157210002400351X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near infrared photothermal inactivation of Candida albicans assisted by plasmonic nanorods","authors":"Gabrielli Maria Ferreira de Oliveira ,&nbsp;Túlio de Lima Pedrosa ,&nbsp;Renato Evangelista de Araujo","doi":"10.1016/j.pdpdt.2024.104309","DOIUrl":"10.1016/j.pdpdt.2024.104309","url":null,"abstract":"<div><p>The use of photothermal processes has been proven effective in the control of microbial infections. Simultaneously, the localized surface plasmon resonance phenomena in metallic nanoparticles have been explored as an alternative strategy to achieve highly efficient localized heating. In this work, we propose the use of selected nanoheaters to improve the efficiency of fungal photothermal inactivation of <em>Candida albicans</em> through size optimization of plasmonic gold nanorods. Here, the optical heating of polyethylene glycol coated gold nanorods of varying sizes is evaluated, both theoretically and experimentally. A size-dependent computational approach was applied to identify metallic nanorods with maximized thermal performance at 800 nm, followed by the experimental comparison of optimal and suboptimal nanoheaters. Comparison among samples show temperatures of up to <span><math><mrow><mn>53</mn><mo>.</mo><mn>0</mn></mrow></math></span> °C for <span><math><mrow><mrow><mn>41</mn></mrow><mo>×</mo><mrow><mn>10</mn></mrow></mrow></math></span> nm gold nanorods against <span><math><mrow><mn>32</mn><mo>.</mo><mn>3</mn></mrow></math></span> °C for <span><math><mrow><mrow><mn>90</mn></mrow><mo>×</mo><mrow><mn>25</mn></mrow></mrow></math></span> nm, a percentage increase of <span><math><mo>∼</mo></math></span>63% in photothermal inactivation assessments. Our findings reveal that gold nanorods of <span><math><mrow><mrow><mn>41</mn></mrow><mo>×</mo><mrow><mn>10</mn></mrow></mrow></math></span> nm exhibit superior efficiency in near-infrared (800 nm) photothermal inactivation of fungi, owing to their higher light-thermal conversion efficiency. The identification of high performance metallic nanoheaters may lead to the reduction of the nanoparticle dose used in plasmonic-based procedures and decrease the laser exposure time needed to induce cell death. Moreover, our results provide insights to better exploit plasmonic nanoparticles on photothermal inactivation protocols.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104309"},"PeriodicalIF":3.1,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003466/pdfft?md5=c7da538e4e50527b326e306ea84036a7&pid=1-s2.0-S1572100024003466-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIR-triggered NO production combined with photodynamic therapy for tumor treatment","authors":"Zhiyuan Lin ,&nbsp;Tao Zhu ,&nbsp;Xiaoqin Zhong","doi":"10.1016/j.pdpdt.2024.104241","DOIUrl":"10.1016/j.pdpdt.2024.104241","url":null,"abstract":"<div><p>Photodynamic therapy (PDT), as one of the most promising cancer therapy methods, is still limited by several drawbacks, such as tissue hypoxia and shallow light penetration of blue-violet light (200–450 nm), and red light (750 nm) is more penetrating to tissues than blue-violet light, but still lower than near-red light (750–1350 nm). Therefore, we proposed a synergistic therapy system by combining the near-infrared light-triggered PDT with nitric oxide (NO)-based gas therapy to enhance the anti-tumor effects. Upconversion nanoparticles (UCNPs) were loaded with the photosensitizers of ZnPc and the NO donors of l-arginine (L-Arg) to obtain the nanocomposites of UCN@mSiO₂@ZnPc@L-Arg. Under 980 nm laser irradiation, reactive oxygen species (ROS) could be produced for PDT and react with l-Arg to produce NO, which is previously reported to have a greater killing effect on tumor cells than ROS and also plays an important role in promoting PDT in our study. Both the in vitro and in vivo tests demonstrated that the combined therapy of PDT with NO therapy could enhance the tumor killing effect significantly compared with the unique application of PDT. The UCNPs-based nanocomposites are expected to be widely used in biomedicine for tumor inhibition.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104241"},"PeriodicalIF":3.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002783/pdfft?md5=6afdc83138dd57166f45257127206835&pid=1-s2.0-S1572100024002783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photodynamic therapy on peripheral immune system for unresectable cholangiocarcinoma","authors":"Xinqiang Wu ,&nbsp;Xiaofeng Jiang ,&nbsp;Zhaoyuan Liu ,&nbsp;Ping Xue ,&nbsp;Yubin Chen ,&nbsp;Liangqi Cao ,&nbsp;Zilong Wen ,&nbsp;Yunqiang Tang","doi":"10.1016/j.pdpdt.2024.104279","DOIUrl":"10.1016/j.pdpdt.2024.104279","url":null,"abstract":"<div><h3>Background</h3><p>Photodynamic therapy (PDT) has been emerging as a promising treatment for unresectable cholangiocarcinoma (CCA). A number of experiments have demonstrated that PDT could enhance antitumor immunity significantly. However, the impact of PDT on peripheral immune system for unresectable CCA remains unclear.</p></div><div><h3>Methods</h3><p>In a clinical trial comparing the perioperative and long-term outcomes of PDT+stent treatment and stent alone treatment for unresectable CCA, we tested the levels of lymphocytes (CD4+ T cells, CD8+ T cells, NK cells, B cells and Treg cells) and immune-related cytokines (IL-4, IL-6, IL-10, TNF-α, TGF-β, perforin, GM-CSF and IFN-γ) in peripheral blood before and after PDT+stent treatment or stent alone treatment and analyzed the influence of PDT on peripheral immune system for unresectable CCA.</p></div><div><h3>Results</h3><p>Before treatment, the levels of all the immune cells and immune-related cytokines did not show significant differences between the PDT+stent group and stent alone group. The ratio of CD8+ T cells increased significantly after PDT treatment, but other kinds of lymphocytes did not show significant difference. Increased level of IL-6 and decreased level of perforin and TGF-β after PDT treatment were demonstrated, whereas no significant changes were found for other immune-related cytokines.</p></div><div><h3>Conclusion</h3><p>PDT altered the levels of immune cells and immune-related cytokines in the peripheral blood of unresectable CCA patients, potentially correlating with the therapeutic efficacy of PDT in unresectable CCA treatment. Future studies could delve deeper into this aspect to explore how PDT can be more effectively utilized in the management of unresectable CCA.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104279"},"PeriodicalIF":3.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003168/pdfft?md5=189aca818f59bee6e703f7d5d4b5c2ae&pid=1-s2.0-S1572100024003168-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of internal limiting membrane peeling versus internal limiting membrane flap insertion for treating idiopathic macular holes","authors":"Xueying Ma ,&nbsp;Jie Sun ,&nbsp;Qiaohong Liang,&nbsp;Yuerong Kong,&nbsp;Hong Yang,&nbsp;Xiaogang Huang","doi":"10.1016/j.pdpdt.2024.104311","DOIUrl":"10.1016/j.pdpdt.2024.104311","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the clinical efficacy of internal limiting membrane (ILM) peeling combined with perimacular hole massage versus ILM flap insertion in the management of patients with idiopathic macular holes was conducted.</p></div><div><h3>Methods</h3><p>35 patients (total of 35 eyes) with idiopathic macular holes (with hole diameters ranging from 366 to 1430 μm) were divided into two groups—Group A consisted of 20 eyes that underwent pars plana vitrectomy (PPV) combined with ILM peeling and perimacular hole massage, while Group B comprised 15 eyes that underwent PPV combined with ILM flap insertion. Subsequent follow-up examinations were performed at 1 week, 1 month, and 3 months post-surgery. The study also involved a comparison of best corrected visual acuity (BCVA) and optical coherence tomography (OCT) classifications between both the patient groups.</p></div><div><h3>Results</h3><p>The macular hole closure rates in Group A were 60 %, while in Group B, the closure rate was 93 %. There was significant difference in hiatus healing rate between the two groups (<em>t</em> = 4.843, <em>p</em> = 0.048). The difference in BCVA at 3 months post-operation between the two groups was statistically significant (<em>t</em> = 3.221, <em>p</em> = 0.003). Three months post-operatively, the BCVA in Group B demonstrated improvement compared to the pre-operative BCVA, with a statistically significant difference (<em>p</em> &gt; 0.05). Three months post-operatively, the BCVA in Group A demonstrated improvement compared to the pre-operative BCVA, but this difference was not statistically significant (<em>p</em> &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>The combination of PPV with ILM flap insertion demonstrates favorable therapeutic efficacy in the treatment of idiopathic macular holes, leading to improved visual acuity.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104311"},"PeriodicalIF":3.1,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S157210002400348X/pdfft?md5=2276396f86ff77898a70e99c276013de&pid=1-s2.0-S157210002400348X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nanotube-modified adhesive to caries affected dentin conditioned with Nd: YAP laser, phosphoric acid, and photoactivated-erythrosine","authors":"Fahad Alkhudhairy ,&nbsp;Mohammad H. AlRefeai","doi":"10.1016/j.pdpdt.2024.104307","DOIUrl":"10.1016/j.pdpdt.2024.104307","url":null,"abstract":"<div><h3>Aim</h3><p>Dentin conditioned with phosphoric acid (PA) Nd: YAP laser, and photoactivated-Ery(Erythrosine) on microleakage, shear bond strength (SBS) degree of conversion (DC), and rheological assessment of adhesive-infused with carbon nanotubes (CNTs).</p></div><div><h3>Material and method</h3><p>Carious ninety-six human mandibular molars were included. Specimens were disinfected and allocated into three groups based on surface pretreatment (<em>n</em> = 32) Group 1 (PA), Group 2 (Nd: YAP) laser, and Group 3 (Photoactivated-Ery). Conditioned groups were further divided into two 2 subgroups based on the application of unmodified ERA and CNTs-modified ERA. Composite restorations were placed on the CAD surface and thermal aging of the samples was performed. The microleakage assessment was conducted using a dye penetration test. Universal testing machine (UTM) assessed SBS bond failure was evaluated using a stereomicroscope. Scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) analyses of CNT, and Fourier Transform Infrared FTIR of adhesives were performed. One-way ANOVA and Tukey post hoc analyzed the outcomes.</p></div><div><h3>Results</h3><p>Group 1B samples (PA+ CNTs modified adhesive) presented the minimum marginal leakage and highest bond integrity. Group 2A (Nd:YAP laser+Unmodified adhesive) displayed the maximum scores of microleakage and lowest bond strength.</p></div><div><h3>Conclusion</h3><p>Photoactivated Ery-PS can serve as an alternative to phosphoric acid for conditioning CAD. Incorporating CNT in adhesive significantly enhanced bond integrity and marginal seal with no significant difference in DC.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104307"},"PeriodicalIF":3.1,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003442/pdfft?md5=24817e563e773dc1b328fc317b08f2ab&pid=1-s2.0-S1572100024003442-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}