Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Titanium oxide and chitosan nanoparticles loaded in methylene blue activated by photodynamic therapy on caries-affected dentin disinfection, bond strength, and smear layer removal efficacy","authors":"Sari Luthfiyah","doi":"10.1016/j.pdpdt.2025.104491","DOIUrl":"10.1016/j.pdpdt.2025.104491","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104491"},"PeriodicalIF":3.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of light-emitting diode-mediated photobiomodulation therapy on orthodontic tooth movement: A literature review","authors":"Rashin Bahrami ,&nbsp;Nariman Nikparto ,&nbsp;Fateme Gharibpour ,&nbsp;Maryam Pourhajibagher ,&nbsp;Abbas Bahador","doi":"10.1016/j.pdpdt.2025.104488","DOIUrl":"10.1016/j.pdpdt.2025.104488","url":null,"abstract":"<div><div>This study aims to review and analyze the impact of light-emitting diode (LED) photobiomodulation (PBM) therapy on orthodontic tooth movement. This non-invasive technique is proposed to reduce time-related side effects, such as white spot lesions, dental caries, and root resorption. Five studies were included in the review, comprising two animal studies (ages 10 and 12 weeks) and three human studies (ages ranging from 15 to 17 years). All studies applied PBM concurrently with force application using sliding mechanics for canine retraction (three studies) and molar protraction (two studies). Two studies employed LEDs with a wavelength of 850 nm, with an exposure time of 5 min daily. Another two studies used LEDs with a wavelength of 618 nm, with an exposure time of 20 min daily. In summary, these studies demonstrated that LED-mediated PBM enhanced orthodontic tooth movement by 33 % (a 1.36-fold increase) compared to the control group. The mean tooth movement per month was 1.55 ± 0.33 mm, which was higher than the control group's average of 1.06 ± 0.35 mm. Also, no studies demonstrated any side effects such as anchorage loss, root resorption, canine rotation, or tooth inclinations. In conclusion, LED-mediated PBM (at wavelengths of 618 nm and 850 nm) can accelerate orthodontic tooth movement without adverse effects, thanks to its biostimulatory properties. Given the advantages of LEDs over traditional lasers—particularly their lower cost and easier application—this method shows promise as a tool to accelerate tooth movement, potentially reducing treatment time and associated side effects.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104488"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALA photodynamic therapy combined with dual 980nm/1470nm diode laser for classic Kaposi's sarcoma","authors":"Yajing Cao ,&nbsp;Dixin Wang ,&nbsp;Yeqiang Liu ,&nbsp;Linglin Zhang ,&nbsp;Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104487","DOIUrl":"10.1016/j.pdpdt.2025.104487","url":null,"abstract":"<div><div>A 84-year old man who has a history of refractory Kaposi's sarcoma (KS) was treated with ALA-PDT combined with the dual 980-nm/1470-nm diode laser for 6 times every other week. Satisfactory result was noted without any unbearable adverse effects. The combination of the dual 980nm/1470 nm diode laser and ALA-PDT may be astrategy in treating local KS with good tolerance, especially in elder patients who can not tolerate radiotherapy and chemotherapy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104487"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of optic disc and macular microvasculature in children with anisometropic amblyopia before and after treatment","authors":"Jia-Hao Li ,&nbsp;Chen-Yu Yang ,&nbsp;Jia-Yu Ma ,&nbsp;Jing Wang ,&nbsp;Ying-Jun Li","doi":"10.1016/j.pdpdt.2025.104481","DOIUrl":"10.1016/j.pdpdt.2025.104481","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate optic disc and macular microvasculature changes in children with anisometropic amblyopia before and after treatment.</div></div><div><h3>Methods</h3><div>In all, 60 children with unilateral anisometropic amblyopia between the ages of 6 and 12 were randomly selected from the ophthalmology clinic of Fuyang People's Hospital, while 60 children with non-amblyopia in the same age range were randomly selected as a normal control group. The right eye was uniformly taken in the control group with at least 6 months of follow-up. Optical coherence tomography angiography (OCTA) was used to evaluate the macular vessel density of superficial capillary plexus (SCP) and deep capillary plexus (DCP), optic disc vascular density (VD), foveal avascular zone (FAZ) area, macular thickness, and retinal nerve fiber layer thickness (RNFLT).</div></div><div><h3>Results</h3><div>Before treatment, the vessel density of the optic disc, macular SCP and DCP in the amblyopic group was significantly lower than those in the fellow eyes and the control group (<em>P</em> &lt; 0.05), while there were no statistically significant differences in the vessel densities of the optic disc, macular SCP and DCP between the amblyopic eyes, the fellow eyes, and the control group after treatment (<em>P</em> &gt; 0.05). Statistically significant negative correlations were found between the alterations of BCVA in amblyopic eyes and the alterations of the vessel densities of the optic disc, macular SCP and DCP in amblyopia eyes (<em>P</em> &lt; 0.05) except for superior nasal (SN) and inferior nasal (IN) regions of the optic disc radial peripapillary capillary, temporal and nasal regions of macular parafoveal SCP, nasal regions of macular parafoveal DCP and inferior regions of macular perifoveal DCP (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Macular and optic disc vessel density in OCTA are lower in children with anisometropic amblyopia and tend to return to normal levels to a certain extent following treatment for amblyopia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104481"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of raman spectroscopy in the non-invasive diagnosis of urological diseases via urine","authors":"Ailiyaer Ainiwaer ,&nbsp;ShuWen Sun ,&nbsp;Ayinuer Bohetiyaer ,&nbsp;Yuchao Liu ,&nbsp;Yufeng Jiang ,&nbsp;Wentao Zhang ,&nbsp;JingCheng Zhang ,&nbsp;Tianyuan Xu ,&nbsp;Hanyang Chen ,&nbsp;Xudong Yao ,&nbsp;Chengyou Jia ,&nbsp;Yang Yan","doi":"10.1016/j.pdpdt.2025.104477","DOIUrl":"10.1016/j.pdpdt.2025.104477","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective of this review is to provide a comprehensive overview of the utilization of Raman spectroscopy in urinary system diseases, highlighting its potential in non-invasive diagnostic methodologies for early diagnosis and prognostic assessment of urinary ailments.</div></div><div><h3>Methods</h3><div>We searched PubMed, Web of Science, and Google Scholar using 'raman,' 'bladder,' 'kidney,' 'prostate,' 'cancer,' 'infection,' 'stone or urinary calculi,' and 'urine or urinary,' along with 'AND' and 'OR' to refine our search. We excluded irrelevant articles and screened potential ones based on titles and abstracts before assessing the full texts for relevance and quality.</div></div><div><h3>Findings</h3><div>The findings indicate that RS can furnish data on biomolecules in urine, which is significant for non-invasive diagnostic approaches. It has shown potential within non-invasive diagnostic methodologies and is expected to play a pivotal role in the early diagnosis and prognostic assessment of urinary system diseases, such as malignancies, urinary tract infections, kidney diseases, urolithiasis, and other urinary conditions.</div></div><div><h3>Conclusions</h3><div>Raman spectroscopy has demonstrated significant potential in providing precise and rapid diagnostic approaches for clinical use in the context of urinary system diseases. Its ability to analyze biomolecules non-invasively positions it as an increasingly important tool in the early diagnosis and prognostic assessment of these conditions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104477"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-surgical mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of peri-implantitis among patients undergoing chemotherapy","authors":"Asma Saleh Almeslet ,&nbsp;Malak Mohammed ALOsaimi ,&nbsp;Chitra Jhugroo ,&nbsp;Abdullah Faraj Alshammari ,&nbsp;Darshan Devang Divakar ,&nbsp;Cristalle Soman","doi":"10.1016/j.pdpdt.2025.104476","DOIUrl":"10.1016/j.pdpdt.2025.104476","url":null,"abstract":"<div><h3>Objective</h3><div>Studies have shown that a single session of antimicrobial photodynamic therapy (aPDT) as an adjunct to mechanical debridement (MD) is effective for treating peri‑implant diseases. The objective was to assess the efficacy of MD with and without adjunct aPDT in treating peri‑implantitis among patients undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>Patients with peri‑implantitis were included. These individuals were divided into two groups (a) patients with peri‑implantitis undergoing chemotherapy; (b) systemically healthy patients with peri‑implantitis. These individuals were further subclassified into two subgroups: (a) individuals that received NSMD alone and (b) individuals that underwent NSMD with adjunct aPDT. Non-surgical MD was performed using plastic curettes. The aPDT was performed using a 680 nm diode laser at a power and power density of 150 mW and 1.1 mW/cm², respectively. The photosensitizer was placed in the peri‑implant pocket and left in place for 60 s following which the laser was applied using a using an optical fiber with a diameter of 600 μm. Peri-implant modified plaque and gingival indices (mPI and mGI), probing depth (PD) and crestal bone loss (CBL) were measured at baseline and after three months. Group comparisons were performed using one way analysis of variance and Bonferroni post-hoc adjustment tests. P-values &lt;0.05 were considered statistically significant.</div></div><div><h3>Results</h3><div>At baseline, there was no statistically significant difference in peri‑implant mPI, mGI, PD and CBL among patients undergoing chemotherapy and systemically healthy individuals with peri‑implantitis. At three months’ follow up, there was no statistically significant difference in peri‑implant mPI, mGI, PD and CBL among patients undergoing chemotherapy and systemically healthy individuals with peri‑implantitis compared to their respective baseline scores.</div></div><div><h3>Conclusion</h3><div>Among patients undergoing chemotherapy and systemically healthy individuals, a single session of aPDT and NSMD is ineffective in the treatment of peri‑implantitis. Nevertheless, poor oral hygiene of the participants and the short-term follow-up may have influenced the results. Hence further long-term follow-up clinical trials involving multiple sessions of aPDT after MD are needed.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104476"},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence images of skin lesions and automated diagnosis using convolutional neural networks","authors":"Matheus B. Rocha ,&nbsp;Sebastiao Pratavieira ,&nbsp;Renan Souza Vieira ,&nbsp;Juliana Duarte Geller ,&nbsp;Amanda Lima Mutz Stein ,&nbsp;Fernanda Sales Soares de Oliveira ,&nbsp;Tania R.P. Canuto ,&nbsp;Luciana de Paula Vieira ,&nbsp;Renan Rossoni ,&nbsp;Maria C.S. Santos ,&nbsp;Patricia H.L. Frasson ,&nbsp;Renato A. Krohling","doi":"10.1016/j.pdpdt.2024.104462","DOIUrl":"10.1016/j.pdpdt.2024.104462","url":null,"abstract":"<div><div>In recent years, interest in applying deep learning (DL) to medical diagnosis has rapidly increased, driven primarily by the development of Convolutional Neural Networks and Transformers. Despite advancements in DL, the automated diagnosis of skin cancer remains a significant challenge. Emulating dermatologists, deep learning approaches using clinical images acquired from smartphones and considering patient lesion information have achieved performance levels close to those of specialists. While including clinical information, such as whether the lesion bleeds, hurts, or itches, improves diagnostic metrics, it is insufficient for correctly differentiating some major skin cancer lesions. An alternate technology for diagnosing skin cancer is fluorescence widefield imaging, where the skin lesion is illuminated with excitation light, causing it to emit fluorescence. Since there is no public dataset of fluorescence images for skin lesions, to the best of our knowledge, an effort has been made and resulted in 1,563 fluorescence images of major skin lesions taken by smartphones using the handheld LED wieldfield fluorescence device. The collected images were annotated and analyzed, creating a new dataset named FLUO-SC. Convolutional neural networks were then applied to classify skin lesions using these fluorescence images. Experimental results indicate that fluorescence images are competitive with clinical images (baseline) for classifying major skin lesions and show promising potential for discrimination.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"52 ","pages":"Article 104462"},"PeriodicalIF":3.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleaching efficacy of in-office bleaching with violet light using low-concentration hydrogen peroxide nanoparticulate photocatalyst gel: A randomized controlled trial","authors":"Gustavo Garcia Castro ,&nbsp;Palena Araújo Pinto ,&nbsp;Michael Willian Favoreto ,&nbsp;Alessandra Reis ,&nbsp;Maria Viviana-Mora ,&nbsp;Rita de Cássia Mendonça de Miranda ,&nbsp;Andres Felipe Milan Cardenas ,&nbsp;Alessandro D. Loguercio ,&nbsp;Rudys Rodolfo de Jesus Tavarez","doi":"10.1016/j.pdpdt.2024.104410","DOIUrl":"10.1016/j.pdpdt.2024.104410","url":null,"abstract":"<div><h3>Objective</h3><div>This randomized controlled trial aimed to evaluate the bleaching efficacy and tooth sensitivity (TS) of participants submitted to different application protocols of in-office bleaching with violet light using 6 % hydrogen peroxide (HP) nanoparticulate photocatalyst gel.</div></div><div><h3>Materials and methods</h3><div>Sixty-six participants were randomized and bleached using either a 6 % HP (Nano White, DMC), and/or violet light (Bright Max Whitening, MMOptics), according to the following protocols: 1) only violet light (VIOL); 2) only bleaching gel application (BG) and; 3) combined bleaching gel application + violet light (BG+VIOL). The bleaching efficacy was evaluated with the Vita Easyshade spectrophotometer, Vita Classical and Vita Bleachedguide scales. The risk and intensity of TS were recorded using a 0–10 visual analogue scale (VAS) and a 0–4 numerical scale (NRS). Color change and intensity of TS values were compared using one-way ANOVA and Tukey's test were used. The absolute risk of TS was compared using the Chi-square test (α = 0.05).</div></div><div><h3>Results</h3><div>A significant and higher degree of bleaching was observed in the BG and BG+VIOL groups compared to the VIOL group (<em>p</em> &lt; 0.003). Despite no significant differences in the risk (<em>p</em> &gt; 0.07) and intensity (<em>p</em> &gt; 0.28) of TS among groups, a higher risk of TS was observed in the BG and BG+VIOL groups.</div></div><div><h3>Conclusions</h3><div>Using VIOL reduced the risk of TS but did not improve bleaching. However, BG+VIOL with low-concentration HP nanoparticulate photocatalyst gel achieved equal efficacy and was less likely to cause TS compared to BG.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104410"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study","authors":"Gokcen Unal Kocabas ,&nbsp;Onur Furundaoturan ,&nbsp;Cumali Degırmencı ,&nbsp;Su Ozgur ,&nbsp;Meltem Kocamanoglu ,&nbsp;Cigdem Gozde Aslan ,&nbsp;Esma Pehlivan Koroglu ,&nbsp;Filiz Afrashı ,&nbsp;Yasemin Akcay ,&nbsp;Ilgin Yildirim Simsir ,&nbsp;Banu Sarer Yurekli","doi":"10.1016/j.pdpdt.2024.104415","DOIUrl":"10.1016/j.pdpdt.2024.104415","url":null,"abstract":"<div><h3>Objective</h3><div>There are controversial results about the effects of GH/IGF-1 on retinal vasculature. Gremlin-1 has roles in both pituitary tumorigenesis and angiogenesis. Therefore, we aimed to detect retinal micro-vascular changes in acromegaly with OCTA and examine its association with serum Gremlin-1 levels.</div></div><div><h3>Design</h3><div>A cross-sectional, case-control study</div></div><div><h3>Methods</h3><div>We included 53 acromegaly patients and age/gender-matched 31 healthy controls. To evaluate retinal structure, optical coherence tomography angiography (OCTA) imaging was performed. Gremlin -1 levels were measured by the ELISA method.</div></div><div><h3>Results</h3><div>Acromegaly patients had significantly lower superficial total density <em>(p</em> <em>&lt;</em> 0.001), superficial parafoveal density (<em>p</em> = 0.002), superficial perifoveal density (<em>p</em> &lt; 0.001); deep total density (<em>p</em> &lt; 0.001), deep parafoveal density (<em>p</em> &lt; 0.001), deep perifoveal density (<em>p</em> &lt; 0.001). Total thickness and perifoveal thickness were significantly lower in the acromegaly group.</div><div>Gremlin-1 levels were significantly lower in acromegaly patients (1.22(0.13) vs 1.38(0.29); <em>p</em> = 0.015, for acromegaly and control groups, respectively). We assessed study groups based on glucose tolerance status. Normal glucose tolerance (NGT) acromegaly patients had significantly lower superficial total density (<em>p</em> = 0.036), superficial perifoveal density (<em>p</em> = 0.003), deep total density (<em>p</em> = 0.023), and deep perifoveal density (<em>p</em> = 0.023) compared to NGT controls. According to backward linear regression analysis, the presence of acromegaly itself consistently showed a significant negative impact on all types of vascular density.</div></div><div><h3>Conclusion</h3><div>Patients with acromegaly have decreased vascular density and lower levels of Gremlin-1 independent of glucose tolerance status. Acromegaly may cause a reduction in gremlin-1 as a compensatory mechanism due to high IGF-1 levels known as an angiogenic factor, which in turn leads to the decrease in vascular density, or gremlin-1 may already have shown a decline in response to chronic inflammation and endothelial dysfunction in acromegaly resulting in a reduction in vascular density.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104415"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of photodynamic therapy in recurrent genital herpes","authors":"Jinyi Chen ,&nbsp;Yuancheng Li ,&nbsp;Dechao Li ,&nbsp;Nian Chen ,&nbsp;Wen Ding ,&nbsp;Ting Zou ,&nbsp;Yang Tan ,&nbsp;Xia Lei","doi":"10.1016/j.pdpdt.2024.104386","DOIUrl":"10.1016/j.pdpdt.2024.104386","url":null,"abstract":"<div><h3>Background</h3><div>Frequently, recurrence of genital herpes imposes significant physical and psychological burdens on patients, and existing treatments are often ineffective in preventing recurrence. Previous studies have indicated that photodynamic therapy (PDT) showed promising outcomes in the treatment of labial herpes simplex virus (HSV) infections; however, its efficacy for genital herpes remained unclear.</div></div><div><h3>Method</h3><div>The study screened patients with genital herpes at Daping Hospital from July 2020 to May 2024. Patients were divided into two groups based on whether they received PDT treatment. Over a one-year follow-up period, patients' healing time and recurrence rates were compared between the two groups. The cumulative incidence of recurrence and restricted mean survival time (RMST) were used to assess outcomes. Propensity score matching (PSM) was employed to minimize bias.</div></div><div><h3>Result</h3><div>A total of 41 patients enrolled in our study, with 8 (19.5 %) received PDT. The non-PDT group exhibited a slower skin lesion healing time, averaging at 7.2 days compared to 5.4 days in the PDT group. A significant difference was observed in the cumulative incidence of recurrence between the PDT and non-PDT groups (37.5 % versus 71.4 %) after PSM. The RMST in the PDT group was 9.94 days, compared to 5.13 days in the non-PDT group before PSM, and 4.14 after PSM.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated that the PDT effectively reduced lesion recovery time and delayed recurrences of genital herpes. We recommend considering PDT as a potential treatment option for patients with recurrent genital herpes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104386"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}