光动力治疗口腔念珠菌病在人类临床试验：循证分析。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-16 DOI:10.1016/j.pdpdt.2025.104729

Yao Lin , Jianfeng Ding , Yufu He , Manting Zhang , Jingqi Zhang , Haotian Zhong , Qinghua Liu , Junbing He

{"title":"光动力治疗口腔念珠菌病在人类临床试验：循证分析。","authors":"Yao Lin , Jianfeng Ding , Yufu He , Manting Zhang , Jingqi Zhang , Haotian Zhong , Qinghua Liu , Junbing He","doi":"10.1016/j.pdpdt.2025.104729","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Traditional antifungal drug treatment (AT) often induce resistance that may limit their ability to eradicate oral candidiasis. This study aimed to evaluate the efficacy of photodynamic therapy (PDT) compared to AT in reducing Candida colony count or improving clinical outcomes in oral candidiasis.</div></div><div><h3>Methods</h3><div>We searched relevant articles through Cochrane Library, Web of Science, and PubMed databases up to June 25, 2024. Randomized controlled trials (RCTs) or other clinical comparative studies assessing the effectiveness of single or adjunctive PDT, or conventional chemical therapies were included. Study outcomes were clinical response or the changes from baseline in Candida colony counts.</div></div><div><h3>Results</h3><div>A total of 16 clinical trials, including 13 RCTs, were enrolled. The pooled results showed PDT and AT therapy for oral candidiasis have comparable efficacy in the overall response rate (RR=0.97, <em>P</em> = 0.540) and no significant difference in the complete response rate between them. PDT+AT had a higher curing rate than AT alone (RR=1.67, CI: 1.16–2.39, <em>P</em> = 0.005). The network meta‑analysis revealed that PDT+AT, PDT or AT alone improved the reduction of Candida colony counts compared to distilled water treatment. Moreover, PDT+AT was significantly more effective than either PDT or AT alone, and it was most likely to provide the greatest benefit in Candida clearance, followed by AT, PDT, chlorhexidine, and distilled water. There was no statistical difference in the improvement of Candida colony counts between the PDT and AT groups.</div></div><div><h3>Conclusions</h3><div>PDT demonstrates comparable efficacy to AT in treating oral candidiasis and may serve as a promising alternative approach. Combining PDT with AT further improves cure rates and Candida reduction. Future large-scale, high-quality RCTs are warranted to confirm these findings.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104729"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photodynamic therapy for oral candidiasis in human clinical trials: an evidence-based analysis\",\"authors\":\"Yao Lin , Jianfeng Ding , Yufu He , Manting Zhang , Jingqi Zhang , Haotian Zhong , Qinghua Liu , Junbing He\",\"doi\":\"10.1016/j.pdpdt.2025.104729\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Traditional antifungal drug treatment (AT) often induce resistance that may limit their ability to eradicate oral candidiasis. This study aimed to evaluate the efficacy of photodynamic therapy (PDT) compared to AT in reducing Candida colony count or improving clinical outcomes in oral candidiasis.</div></div><div><h3>Methods</h3><div>We searched relevant articles through Cochrane Library, Web of Science, and PubMed databases up to June 25, 2024. Randomized controlled trials (RCTs) or other clinical comparative studies assessing the effectiveness of single or adjunctive PDT, or conventional chemical therapies were included. Study outcomes were clinical response or the changes from baseline in Candida colony counts.</div></div><div><h3>Results</h3><div>A total of 16 clinical trials, including 13 RCTs, were enrolled. The pooled results showed PDT and AT therapy for oral candidiasis have comparable efficacy in the overall response rate (RR=0.97, <em>P</em> = 0.540) and no significant difference in the complete response rate between them. PDT+AT had a higher curing rate than AT alone (RR=1.67, CI: 1.16–2.39, <em>P</em> = 0.005). The network meta‑analysis revealed that PDT+AT, PDT or AT alone improved the reduction of Candida colony counts compared to distilled water treatment. Moreover, PDT+AT was significantly more effective than either PDT or AT alone, and it was most likely to provide the greatest benefit in Candida clearance, followed by AT, PDT, chlorhexidine, and distilled water. There was no statistical difference in the improvement of Candida colony counts between the PDT and AT groups.</div></div><div><h3>Conclusions</h3><div>PDT demonstrates comparable efficacy to AT in treating oral candidiasis and may serve as a promising alternative approach. Combining PDT with AT further improves cure rates and Candida reduction. Future large-scale, high-quality RCTs are warranted to confirm these findings.</div></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"54 \",\"pages\":\"Article 104729\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572100025002613\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025002613","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：传统的抗真菌药物治疗（AT）经常引起耐药性，这可能限制其根除口腔念珠菌病的能力。本研究旨在评估光动力治疗（PDT）与AT在减少口腔念珠菌菌落计数或改善口腔念珠菌病临床结果方面的疗效。方法：我们通过Cochrane Library、Web of Science和PubMed数据库检索到2024年6月25日的相关文章。随机对照试验（rct）或其他临床比较研究评估了单一或辅助PDT或常规化学治疗的有效性。研究结果是临床反应或念珠菌菌落计数与基线相比的变化。结果：共纳入16项临床试验，其中rct 13项。综合结果显示，PDT与AT治疗口腔念珠菌病的总有效率相当（RR=0.97， P=0.540），两者的完全有效率无显著差异。PDT+AT的固化率高于单纯AT （RR=1.67, CI: 1.16 ~ 2.39， P=0.005）。网络荟萃分析显示，与蒸馏水处理相比，PDT+AT、PDT或单独使用AT可改善念珠菌菌落计数的减少。此外，PDT+AT明显比单独使用PDT或AT更有效，并且在清除念珠菌方面最有可能提供最大的益处，其次是AT， PDT，氯己定和蒸馏水。PDT组和AT组对念珠菌菌落计数的改善无统计学差异。结论：PDT治疗口腔念珠菌病的疗效与AT相当，可能是一种有希望的替代方法。PDT联合AT进一步提高治愈率和减少念珠菌。未来有必要进行大规模、高质量的随机对照试验来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Photodynamic therapy for oral candidiasis in human clinical trials: an evidence-based analysis

Objectives

Traditional antifungal drug treatment (AT) often induce resistance that may limit their ability to eradicate oral candidiasis. This study aimed to evaluate the efficacy of photodynamic therapy (PDT) compared to AT in reducing Candida colony count or improving clinical outcomes in oral candidiasis.

Methods

We searched relevant articles through Cochrane Library, Web of Science, and PubMed databases up to June 25, 2024. Randomized controlled trials (RCTs) or other clinical comparative studies assessing the effectiveness of single or adjunctive PDT, or conventional chemical therapies were included. Study outcomes were clinical response or the changes from baseline in Candida colony counts.

Results

A total of 16 clinical trials, including 13 RCTs, were enrolled. The pooled results showed PDT and AT therapy for oral candidiasis have comparable efficacy in the overall response rate (RR=0.97, P = 0.540) and no significant difference in the complete response rate between them. PDT+AT had a higher curing rate than AT alone (RR=1.67, CI: 1.16–2.39, P = 0.005). The network meta‑analysis revealed that PDT+AT, PDT or AT alone improved the reduction of Candida colony counts compared to distilled water treatment. Moreover, PDT+AT was significantly more effective than either PDT or AT alone, and it was most likely to provide the greatest benefit in Candida clearance, followed by AT, PDT, chlorhexidine, and distilled water. There was no statistical difference in the improvement of Candida colony counts between the PDT and AT groups.

Conclusions

PDT demonstrates comparable efficacy to AT in treating oral candidiasis and may serve as a promising alternative approach. Combining PDT with AT further improves cure rates and Candida reduction. Future large-scale, high-quality RCTs are warranted to confirm these findings.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.