Effects of monochromatic light on eye growth regulation and Myopia control

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-23 DOI:10.1016/j.pdpdt.2025.104735

Tiange Liu , Jing Wang , Yang Liu , Shiqi Liu , Zihui Gao , Xiaotong Li , Wei Zhang

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Abstract

The application of monochromatic light in myopia has remained a research hotspot in the field of myopia prevention and control. With rapid advances in clinical applications, numerous studies have confirmed its unique potential in slowing axial elongation in children and adolescents. However, the underlying mechanisms of monochromatic light remain inconclusive within the academic community. This review summarizes recent progress in animal studies investigating the effects of monochromatic light characteristics—including wavelength, exposure duration, light intensity, and exposure initiation period—as well as related circadian rhythm disturbances on ocular growth and refractive development. Current evidence suggests that monochromatic light may regulate eye growth through mechanisms such as modulation of retinal cone signaling, dopamine metabolism, and choroidal thickness alterations. In clinical research, investigations of monochromatic light have primarily focused on repeated low-level red light (RLRL) therapy. As an emerging intervention, RLRL has demonstrated potential in slowing myopia progression. However, its long-term efficacy and safety remain topics of ongoing debate. This review synthesizes current findings from both animal and human studies, explores the underlying biological mechanisms, and discusses the challenges associated with the clinical application of RLRL therapy.

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单色光对眼睛生长调节和近视控制的影响。

单色光在近视中的应用一直是近视防治领域的研究热点。随着临床应用的快速发展，许多研究证实了其在减缓儿童和青少年轴向伸长方面的独特潜力。然而，单色光的潜在机制在学术界仍然没有定论。本文综述了单色光特性（包括波长、照射时间、光强和照射起始时间）以及相关昼夜节律紊乱对眼部生长和屈光发育影响的动物研究进展。目前的证据表明，单色光可能通过调节视网膜锥信号、多巴胺代谢和脉络膜厚度改变等机制来调节眼睛的生长。在临床研究中，单色光的研究主要集中在重复低水平红光（RLRL）治疗上。作为一种新兴的干预措施，RLRL已被证明具有减缓近视进展的潜力。然而，其长期疗效和安全性仍是争论不休的话题。本文综合了动物和人类研究的最新发现，探讨了潜在的生物学机制，并讨论了RLRL治疗临床应用的相关挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.