眼周基底细胞癌局部切除及二次意向愈合联合光动力治疗。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-07-20 DOI:10.1016/j.pdpdt.2025.104732

Jing Peng, Honghong Yang, Chengcheng Xiong, Xianfeng Fang, Decheng Wang

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引用次数: 0

摘要

目的：评价局部切除和二次意向愈合联合光动力治疗眼周基底细胞癌（pBCC）的疗效。方法：回顾性分析2022 - 2023年间5例pBCC患者的临床资料。局部肿瘤切除后，术中立即进行PDT治疗，随后通过二次意向愈合和每周PDT治疗进行伤口管理。结果：5例pBCC均获得病灶完全清除，美容效果良好。随访18 ~ 39个月（平均25个月），无复发。结论：联合方案可使手术缺损缩小，简化术后重建，提高肿瘤清除率。它特别适用于位于解剖关键区域的BCC患者，如眼周区域，传统的手术切除是不可行的。

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Local excision and secondary intention healing combined with photodynamic therapy for periocular basal cell carcinoma

Objective

To evaluate the efficacy of combining Local excision and secondary intention healing with photodynamic therapy (PDT) in treating periocular basal cell carcinoma (pBCC).

Methods

Clinical data from 5 pBCC patients treated between 2022 and 2023 were retrospectively analyzed. After local tumor excision, immediate intraoperative PDT was administered, followed by wound management via secondary intention healing and weekly PDT sessions.

Results

Complete lesion clearance was achieved in all 5 cases of pBCC, with favorable cosmetic outcomes. During a follow-up period of 18–39 months (mean 25 months), no recurrence was observed.

Conclusion

The combined protocol minimizes the surgical defect size, simplifies post-procedural reconstruction, and enhances tumor clearance rates. It is particularly suitable for patients with BCC located in anatomically critical regions such as the periocular area, where traditional surgical excision is not amenable.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.