Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Effects of photobiomodulation with 940 Nm diode laser on post-rhinoplasty nasal tip swelling: A randomized controlled trial","authors":"Mohammadreza Jamalpour ,&nbsp;Hanieh Tavassoli Ara ,&nbsp;Fatemeh Sheibani ,&nbsp;Pantea Amiri ,&nbsp;Reza Fekrazad","doi":"10.1016/j.pdpdt.2025.104723","DOIUrl":"10.1016/j.pdpdt.2025.104723","url":null,"abstract":"<div><div>Rhinoplasty, while effective for nasal reshaping, frequently results in postoperative edema and delayed recovery.</div><div>This randomized controlled trial evaluated photobiomodulation (PBM) using a 940 nm diode laser (4 J/cm² energy density, 0.1 W power, 2.27 cm² spot size) for managing nasal swelling in 20 patients following open rhinoplasty. Participants were allocated to laser (16 sessions over 8 weeks) or control groups, with standardized photogrammetric measurements of nasal width and tip rotation preoperatively and at 1, 4, and 8 weeks postoperatively.</div><div>The intervention group demonstrated a mean nasal width reduction of 2.5 mm (<em>p</em> = 0.08) and a 3-degree improvement in tip rotation (<em>p</em> = 0.12) compared to controls, though statistical significance was not achieved. Qualitative assessments revealed marked edema reduction in 70 % of treated patients versus 30 % of controls.</div><div>While limited by sample size, these findings suggest 940 nm PBM may accelerate resolution of post-rhinoplasty swelling through anti-inflammatory mechanisms, warranting further investigation in larger cohorts.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104723"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of topical coenzyme Q10 in conjunction with vitamin e on the pattern visual evoked potential, visual field, retinal ganglion cell layer and retinal nerve fibre layer thickness in patients with primary open-angle glaucoma","authors":"Mahmut Dogan ,&nbsp;Galip Ertugrul Mirza","doi":"10.1016/j.pdpdt.2025.104720","DOIUrl":"10.1016/j.pdpdt.2025.104720","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effects of coenzyme Q10+vitamin E on the pattern visual evoked potential (VEP), visual field, retinal ganglion cell layer and RNFLthickness in patients with primary open-angle glaucoma (POAG).</div></div><div><h3>Methods</h3><div>Ninety-six eyes from forty-eight POAG patients were enrolled. Forty-eight eyes were chosen for the study group, and fellow forty-eight eyes were chosen for the control group. At baseline, 6th month, and 12th month, the VEP, visual field parameters, and optical coherence tomography (OCT) (i.e.RNFL) were recorded for the 48 POAG eyes that underwent treatment with coenzyme Q10+vitamin E (Coqun®) in addition timolol+dorzolamide in study group and for the 48 POAG eyes that were only treated with timolol+dorzolamide in control group.</div></div><div><h3>Results</h3><div>After 12 months, ganglion cell layer of both groups were decreased when compared to baseline (<em>p</em> &lt; 0.05). Although the decrease in the ganglion cell layer in the control group was greater. After 12 months, in control group patients VEP P100 implicit times were increased, whereas P100 amplitudes were decreased (<em>P</em> &lt; 0.05) .In study group patients, VEP P100 implicit times were decreased, whereas P100 amplitudes were increased (<em>P</em> &lt; 0.05) when compared to baseline. At the end of 12 months in the study group, there was no significant change in the 32 patients ( %67), and the current visual field was preserved. (<em>p</em> &gt; 0.05).In the control group at the end of the12 month, 24 ( %50)patients had an increase in MD (<em>p</em> &lt; 0.05). In both groups, the RNFL thickness at 12 months showed a significant decrease (p˂ 0.05) compared to baseline.</div></div><div><h3>Conclusion</h3><div>Currently, neuroprotective drug studies in glaucoma are increasing daily.These results suggest that Coqun® administration in POAG had a beneficial effect on the inner retinal layer with consequent enhancement of the visual cortical responses (VEP improvement),visual field (decreased MD) and protect RNFL thickness.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104720"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of dermatologists and deep learning model on diagnosing childhood vitiligo","authors":"Shijuan Yu ,&nbsp;Zhilin Chen ,&nbsp;Jingyi He ,&nbsp;Hua Wang","doi":"10.1016/j.pdpdt.2025.104727","DOIUrl":"10.1016/j.pdpdt.2025.104727","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the performance of a deep learning (DL) model based on dermoscopy images in diagnosing childhood vitiligo.</div></div><div><h3>Methods</h3><div>A total of 474 pediatric patients (223 with vitiligo and 251 without vitiligo) were enrolled. Three types of imaging data were collected: dermoscopic images, Wood’s lamp images, and standard clinical photographs. Two diagnostic evaluation approaches were established. Clinician-based assessment: Eight dermatologists performed a double-blind evaluation using dermoscopic images. DL-based assessment: ResNet152 and DenseNet121 models were trained on 3896 dermoscopic images (with an 8:2 split between the development set and validation set). The evaluation metrics included the AUC of ROC curve, sensitivity, specificity, F1-score, and accuracy. Additionally, the correlation between clinicians’ diagnostic performance and their years of experience was analyzed.</div></div><div><h3>Results</h3><div>ROC curve analysis revealed that using the training questionnaire as a control group, the diagnostic performance of dermatologists for vitiligo based solely on dermoscopy images yielded an AUC of 0.77 (95 % CI: 0.51–1.00), sensitivity of 0.88 (95 % CI: 0.53–0.99), and specificity of 0.75 (95 % CI: 0.41–0.96). The confusion matrix for the ResNet152 model indicated an accuracy of 83.08 %, a recall rate of 86.84 %, a precision of 81.08 %, a specificity of 79.22 %, an F1 score of 0.8386, and an AUC of 0.91. The confusion matrix for the DenseNet121 model indicated an accuracy of 81.41 % and a recall rate of 83.41 % (precision: 82.03 %, specificity: 79.12 %, F1 score: 0.8271, and AUC: 0.89).</div></div><div><h3>Conclusion</h3><div>Both DL models based on dermoscopy images exhibit high overall classification performance in the diagnosis of childhood vitiligo.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104727"},"PeriodicalIF":2.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of non-invasive photobiomodulation for congenital color vision deficiency: A randomized controlled trial","authors":"Nandi Bao ,&nbsp;Chunyi Jia ,&nbsp;Liang Jia","doi":"10.1016/j.pdpdt.2025.104721","DOIUrl":"10.1016/j.pdpdt.2025.104721","url":null,"abstract":"<div><h3>Background</h3><div>Congenital color vision deficiency (CVD) is a prevalent ophthalmic condition for which effective therapeutic interventions remain limited. This study evaluated the efficacy of photobiomodulation (PBM) therapy in individuals with congenital CVD.</div></div><div><h3>Methods</h3><div>A randomized, single-blind, controlled clinical trial was conducted involving 80 participants diagnosed with red-green CVD. Participants were randomly assigned to either a PBM treatment group or a control group. Color vision performance was assessed at baseline, and after 1, 2, and 4 weeks of intervention. Statistical analyses were conducted using the Kruskal-Wallis test with Dunn’s post hoc test for multiple comparisons.</div></div><div><h3>Results</h3><div>Color vision recognition ability demonstrated a statistically significant improvement in the PBM treatment group compared to the control group across various parameters (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Non-invasive PBM therapy significantly enhances color vision in individuals with congenital CVD, with particularly notable improvements observed in those with green CVD.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104721"},"PeriodicalIF":2.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared photoimmunotherapy for recurrent cancer at the base of the tongue","authors":"Takuma Makino ,&nbsp;Asami Nishikori ,&nbsp;Yasuharu Sato ,&nbsp;Yuto Naoi ,&nbsp;Junya Matsumoto ,&nbsp;Shohei Fujimoto ,&nbsp;Mizuo Ando","doi":"10.1016/j.pdpdt.2025.104719","DOIUrl":"10.1016/j.pdpdt.2025.104719","url":null,"abstract":"<div><div>Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapeutic approach that targets epidermal growth factor receptor (EGFR). In NIR-PIT, administration of cetuximab sarotalocan sodium is followed by laser irradiation of the affected area, which theoretically should induce tumor cell death. However, residual tumors are occasionally observed. This study investigated factors that influence the therapeutic efficacy of NIR-PIT in cases of recurrence of cancer at the base of the tongue. Six patients undergoing 11 treatment cycles were analyzed, focusing on the puncture interval of cylindrical diffusers and the expression of EGFR in tumors. The results demonstrated that a puncture interval of ≤12 mm significantly enhanced therapeutic efficacy, with one case achieving complete response. EGFR expression was positive in all cases and expression score showed no significant change between before and after treatment. These findings suggest that puncture interval plays a critical role in therapeutic outcomes, whereas EGFR expression may not directly influence treatment efficacy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104719"},"PeriodicalIF":2.6,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of selective laser trabeculoplasty in military pilots with open-angle glaucoma: Implications for intraocular pressure control and aeromedical certification","authors":"Hua Wang,&nbsp;Yan-Yan Zhao,&nbsp;Shan-Shan Cao,&nbsp;Wei Chen,&nbsp;Xin Wang,&nbsp;Yong Liu","doi":"10.1016/j.pdpdt.2025.104717","DOIUrl":"10.1016/j.pdpdt.2025.104717","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the clinical efficacy and safety of selective laser trabeculoplasty (SLT) in individuals diagnosed with open-angle glaucoma within the military pilot population and to examine its impact on intraocular pressure (IOP) regulation and aeromedical certification status.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted using clinical data from four military pilots (eight eyes) who underwent SLT at the Ophthalmology Department of the Air Force Characteristics Medical Center between January 2013 and January 2025. Outcomes assessed included 24 h IOP fluctuations before and after SLT, changes in pharmacological management, and medical certification results.</div></div><div><h3>Results</h3><div>A statistically significant reduction in mean IOP was observed in six eyes following SLT (<em>p</em> &lt; 0.05), with accompanying decreases in both the 24 h peak IOP and IOP fluctuation range (<em>p</em> &lt; 0.05). Among the four cases, two individuals demonstrated a reduction or cessation in the use of IOP-lowering medications. All individuals exhibited stable ocular conditions post-treatment and retained or regained their flight qualification status.</div></div><div><h3>Conclusion</h3><div>Based upon the 4 cases of primary open-angle glaucoma investigated, SLT demonstrated favourable safety and efficacy in lowering IOP and reducing medication dependencey in this cohort. Among military pilots with open-angle glaucoma or ocular hypertension, SLT may be regarded as a viable therapeutic option that supports the maintenance of flight readiness and aeromedical certification.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104717"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy on chronic pathology during the post-COVID19 and worldwide shortage of verteporfin (Visudyne®) era","authors":"Ana Boned-Murillo ,&nbsp;Mª Jesús López-Prats Lucea ,&nbsp;Enrique Alfonso Muñoz ,&nbsp;Lourdes Vidal-Oliver ,&nbsp;Jorge Mataix Boronat ,&nbsp;Elena Palacios Pozo ,&nbsp;Mª Carmen Desco Esteban","doi":"10.1016/j.pdpdt.2025.104711","DOIUrl":"10.1016/j.pdpdt.2025.104711","url":null,"abstract":"<div><h3>Background</h3><div>We analyze COVID19 pandemia and shortage of verteporfin (Visudyne®) consequences in photodynamic therapy (PDT) treated patients.</div></div><div><h3>Material and methods</h3><div>A retrospective study was performed in 97 patients treated with PDT last 3 years. We used HALF DOSE PDT for chronic central serous chorioretinopathy (cCSCR) (<em>n</em> = 84) and FULL DOSE for polypoidal choroidal vasculopathy (PCV) (<em>n</em> = 13). We evaluated changes in visual acuity (VA) and resolution of subretinal fluid (SRF) by optical coherence tomography (OCT), assessing the number of retreatments.</div></div><div><h3>Results</h3><div>The mean referral delay time was 28.5 ± 6.24 months. 53.6 % of cCSCR and 75 % of PCV patients received previous treatments. An improvement in VA was observed in cCSCR patients after treatment, while PCV patients tends to stabilization. Patients with longer therapeutic delay (≥1 year) showed worse VA. Complete resolution of SRF was noted in 71.4 % of cCSCR and 83.3 % of PCV patients. The shorter the referral delay, the better the resolution rate (76.9 % &lt; 1 year vs 61.5 % if ≥1 year). One-third-of patients required retreatment, superior if longer delay (26.9 % if &lt;1 year vs 34.3 % if ≥1 year).</div></div><div><h3>Conclusion</h3><div>Even with referral delay or chronic evolution, PDT is worth it and safe to resolve SRF or polyps activity for cCSCR and PCV.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104711"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ray tracing-guided LASIK for high myopia and astigmatism: Initial clinical outcomes","authors":"Lei Luo ,&nbsp;Yimeng Fan ,&nbsp;Xindi Wang ,&nbsp;Linjuan Yang ,&nbsp;Shimin Tan ,&nbsp;Yu Zhang ,&nbsp;Yan Cai ,&nbsp;Jingni Yu ,&nbsp;Zhao Liu ,&nbsp;Shengjian Mi ,&nbsp;Qianyan Kang","doi":"10.1016/j.pdpdt.2025.104715","DOIUrl":"10.1016/j.pdpdt.2025.104715","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate visual acuity, refractive outcomes and ocular higher order aberrations (HOAs) following ray tracing-guided laser-assisted in situ keratomileusis (LASIK) for high myopia and astigmatism.</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 77 eyes in 42 patients with high myopia and astigmatism undergoing ray tracing-guided LASIK. InnvoEyes Sightmap was used for ocular wavefront aberrometry, tomography and biometry assessment. Visual acuity, refractive error and ocular HOAs were evaluated preoperatively and 3 months postoperatively.</div></div><div><h3>Results</h3><div>Preoperative manifest refraction spherical equivalent (MRSE) was -7.52 ± 0.86 D (sphere:6.87 ± 1.02 D; cylinder:1.29 ± 0.82 D). At 3 months, 100 % of eyes achieved uncorrected distance visual acuity (UDVA) ≥ 20/20 with no loss of CDVA. Refractive outcomes showed MRSE within ± 0.50 D in 97 % of eyes and astigmatism within ± 0.25 D in 83 % of eyes. The correction index demonstrated high accuracy (arithmetic: 1.09; geometric: 1.07) with minimal difference vector (0.04 D@99°). While ocular total HOA increased from 0.209 ± 0.080 µm to 0.330 ± 0.108 (<em>p</em> &lt; 0.001), spherical aberration maintained comparable values (0.034 ± 0.067 µm vs 0.038 ± 0.086 µm, <em>p</em> = 0.700).</div></div><div><h3>Conclusions</h3><div>Ray tracing-guided LASIK demonstrated favorable safety, efficacy and predictability for high myopia and astigmatism in this study. Notably, spherical aberration maintained its values after the procedure, suggesting the potential of ray tracing-guided LASIK to optimize visual acuity and refractive outcomes in the correction of high myopia.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"55 ","pages":"Article 104715"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chlorhexidine combined with curcumin-mediated photodynamic treatment effectively inhibits biofilm formation by clinical Candida isolates from the oral cavity","authors":"João Salviano Simões Chagas da Silva ,&nbsp;Maria José Barbaresco ,&nbsp;Reuber Mendes Rocha ,&nbsp;Maria Gabriella Fernandes Ribeiro Eliseu ,&nbsp;Marina de Andrade ,&nbsp;Lucas Danilo Dias ,&nbsp;Plínio Lázaro Faleiro Naves","doi":"10.1016/j.pdpdt.2025.104709","DOIUrl":"10.1016/j.pdpdt.2025.104709","url":null,"abstract":"<div><div>This study evaluated the efficacy of chlorhexidine (CHX) in combination with curcumin-mediated photodynamic therapy (CUR-PDT) against clinical <em>Candida</em> spp. isolates. Seven strains were analyzed, including <em>Candida albicans</em> (Ca2, Ca4, CaATCC 10,231) and <em>Candida krusei</em> (Ck7, Ck8, Ck11, Ck12), previously characterized for their biofilm-forming ability using the crystal violet assay after 48 h of incubation in BHIS medium at 35.5 °C, with an initial inoculum of approximately 1–5 × 10⁵ CFU/mL. Antifungal activity was assessed through the minimum biofilm inhibitory concentration (MBIC₅₀) under both irradiated and non-irradiated conditions using blue LED light at 450 nm (20 and 100 J/cm²). CHX alone exhibited MBIC₅₀ values ranging from 3.71 to 14.84 µM. CUR showed no inhibitory activity in the absence of light, with no measurable MIC or MBIC₅₀ values. Upon irradiation, CUR exhibited MBIC₅₀ values ranging from 4 to 64 µM, depending on the strain and light dose. The combined CHX + CUR treatment under 100 J/cm² irradiation demonstrated a pronounced additive effect, reducing MBIC₅₀ values to 0.625 µM for all strains except <em>Candida albicans</em> Ca2, which required 1.25 µM. This combination achieved biofilm inhibition rates exceeding 90 % (<em>p</em> &lt; 0.05). These findings indicate that CHX combined with CUR-PDT under high-dose irradiation significantly enhances biofilm inhibition in <em>Candida</em> spp., supporting its potential as a promising antifungal strategy for the management of biofilm-associated infections.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104709"},"PeriodicalIF":3.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic nephropathy nomogram construction based on optical coherence tomography angiography variables","authors":"Lobsang Tshedron ,&nbsp;Zijing Li","doi":"10.1016/j.pdpdt.2025.104718","DOIUrl":"10.1016/j.pdpdt.2025.104718","url":null,"abstract":"<div><h3>Aims</h3><div>To develop a prediction model and corresponding nomogram for diabetic nephropathy (DN) using optical coherence tomography angiography (OCTA) variables.</div></div><div><h3>Methods</h3><div>Patients with type 2 diabetes mellitus (T2DM) were retrospectively enrolled during diabetic retinopathy screening and randomly assigned to training and validation sets in a 7:3 ratio. Predictive OCTA variables were selected using the least absolute shrinkage and selection operator (LASSO) method and used to establish the model. Model performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis. A nomogram was then constructed based on the final model.</div></div><div><h3>Results</h3><div>A total of 324 eyes were included in the training set and 140 in the validation set. Deep capillary plexus (DCP) parafoveal density, foveal capillary density in the 300 µm-wide area surrounding the foveal avascular zone (FD-300), age, sex, and axial length were incorporated into the model. In the training set, the model achieved a C-index of 0.728 with single sampling and 0.747 with repeated sampling. In the validation set, the C-index was 0.678 with single sampling and 0.681 with repeated sampling. Calibration curves demonstrated good agreement between predicted and observed outcomes in both sets. Decision curve analysis supported the clinical utility and applicability of the nomogram.</div></div><div><h3>Conclusions</h3><div>We developed a prediction model for DN with relatively good performance using OCTA-derived variables. DCP density and the FD-300 area were identified as key predictors. The resulting nomogram may serve as a useful diagnostic tool for DN and support future advances in OCTA-based artificial intelligence diagnostic systems. However, as external validation datasets are still missing, the results of this study should still be considered somewhat preliminary.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"54 ","pages":"Article 104718"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}