Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Distribution and inter-device agreement of chord mu/alpha lengths and axes between Pentacam HR, Sirius, and IOLMaster 700","authors":"Armin Doostparast ,&nbsp;Maryam Ghandhari ,&nbsp;Mohammadreza Rastegar ,&nbsp;Amir Hossein Khosronejad ,&nbsp;Mohammadreza Ghandhari ,&nbsp;Alireza Eslampoor","doi":"10.1016/j.pdpdt.2025.105275","DOIUrl":"10.1016/j.pdpdt.2025.105275","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the distribution and inter-device agreement of chord mu (C-µ) and chord alpha (C-α) lengths and axes across three imaging systems—Pentacam HR, Sirius, and IOLMaster 700—in healthy candidates for refractive surgery.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 101 healthy right eyes. C-µ and C-α were obtained from Pentacam HR, Sirius, and IOLMaster 700. Agreement was assessed using intraclass correlation coefficients (ICC), circular correlation coefficients (CCC), Bland-Altman plots, and paired <em>t</em>-tests. Subgroup analyses were conducted based on refractive status and myopia severity.</div></div><div><h3>Results</h3><div>C-µ and C-α lengths were significantly greater in hyperopic than myopic eyes (C-µ: +0.11–0.13 mm; C-α: +0.15–0.16 mm; P &lt; 0.001). No associations were found with gender or myopia severity. Inter-device agreement for C-µ length was moderate to good overall (ICC: 0.56–0.73), and best in hyperopic eyes (ICC: 0.79–0.91). For the C-µ axis, CCC values showed good agreement between Pentacam HR and Sirius (CCC = 0.81), and moderate agreement between Sirius–IOLMaster 700 (CCC = 0.70) and Pentacam HR–IOLMaster 700 (CCC = 0.68). C-α measurements (available only for Pentacam HR and IOLMaster 700) showed moderate agreement (ICC = 0.68, CCC = 0.51).</div></div><div><h3>Conclusion</h3><div>C-µ and C-α measurements vary significantly across devices, with the poorest agreement consistently observed between Pentacam HR and IOLMaster 700, particularly in myopic eyes. These discrepancies are clinically relevant when planning centration-sensitive procedures such as multifocal intraocular lens implantation or wavefront-guided laser-assisted in situ keratomileusis. Surgeons should account for inter-device variability and consider device-specific measurement biases when planning treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105275"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of dermoscopic characteristics in vitiligo lesions treated with autologous non-cultured epidermal cell suspension transplantation: A prospective study","authors":"Rongsi Sun ,&nbsp;Yuqing Hu ,&nbsp;Xiaoyi Shi,&nbsp;Yukun Yuan,&nbsp;Mengyi Zhu,&nbsp;Xiaolan Ding","doi":"10.1016/j.pdpdt.2025.105279","DOIUrl":"10.1016/j.pdpdt.2025.105279","url":null,"abstract":"<div><h3>Background</h3><div>Non-cultured epidermal cell suspension (NCES) transplantation, as a cellular grafting technique to treat stable vitiligo, is gaining wider acceptance among dermatologists. However, the continuous dermoscopic characteristics of the vitiligo lesions treated with NCES transplantation have not been fully investigated.</div></div><div><h3>Objective</h3><div>To observe the dermoscopic features of vitiligo lesions treated with NCES transplantation and identify the repigmentation-associated indicators.</div></div><div><h3>Methods</h3><div>Patients with stable vitiligo were enrolled and received NCES transplantation. All patients were followed up and underwent dermoscopy examination of the recipient sites at 1, 2, 3, 4, 5 and 6 months postoperatively.</div></div><div><h3>Results</h3><div>Among 8 patches with excellent repigmentation (&gt;80 % repigmentation), six dermoscopic features exhibited significant changes. The emergence of poorly-defined border and altered pigment network signified the appearance of repigmentation.</div></div><div><h3>Conclusion</h3><div>Dermoscopy can effectively and dynamically reflect subtle changes in vitiligo lesions treated with NCES transplantation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105279"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of subjective efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of refractory vulvar lichen sclerosus","authors":"Guiqin Chen ,&nbsp;Yicheng Li ,&nbsp;Jingyi Mu ,&nbsp;Zhenzhen Lu ,&nbsp;Lei Cao ,&nbsp;Xin Cheng ,&nbsp;Yue Wang","doi":"10.1016/j.pdpdt.2025.104768","DOIUrl":"10.1016/j.pdpdt.2025.104768","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in refractory Vulvar lichen sclerosus (VLS) patients. <strong><em>Methods</em></strong><em>:</em> This prospective study enrolled a total of 60 patients with refractory VLS. These patients received 6 sessions of ALA-PDT treatment. Follow-ups were conducted at 3, 6 and 12 months after treatment to evaluate the improvement of patients' subjective symptom and objective clinical signs. In addition, the Dermatology Life Quality Index (DLQI) was used to assess the quality of life (QoL) of patients after treatment.</div></div><div><h3>Results</h3><div>Significant reductions were observed in both itching and burning pain scores post-treatment (p &lt; 0.05). Objective clinical signs also demonstrated marked improvement (p &lt; 0.01). At 12 months after treatment, 53 of 60 patients (88.33%) achieved clinically significant response (defined as ≥50% reduction in symptom scores). The DLQI score decreased from 20 points before treatment to 4, 2, and 3, indicating enhanced QoL. Most adverse reactions were mild and resolved with supportive care.</div></div><div><h3>Conclusion</h3><div>ALA-PDT represents a promising therapeutic alternative for refractory VLS, offering sustained symptom relief and objective clinical improvement with a favorable safety profile.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104768"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning predictive model based on the corneal biomechanics of clinical data","authors":"Tianyu Shi","doi":"10.1016/j.pdpdt.2025.105262","DOIUrl":"10.1016/j.pdpdt.2025.105262","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a machine learning model for predicting postoperative corneal ectasia risk after refractive surgery by integrating multidimensional preoperative and postoperative biomechanical parameters.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 200 patients who underwent LASIK or SMILE at Shenyang Xingqi Eye Hospital between January 2023 and December 2024 was analyzed. Variables including corneal morphology, biomechanics, and early postoperative changes were screened using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Multiple algorithms—generalized linear model (GLM), gradient boosting machine (GBM), and support vector machine (SVM)—were compared via 10-fold cross-validation. The optimal SVM model was fine-tuned through grid search and further tested in a prospective temporal validation cohort (<em>n</em> = 40, January–September 2025). Model performance was evaluated by AUC, calibration, and decision-curve analysis.</div></div><div><h3>Results</h3><div>LASSO identified PreopCCT, PreopKmax, CH, CRF, and early postoperative changes (PostopCCTChange1m, PostopKmaxChange3m) as key predictors. The SVM model achieved the best discrimination among all models (AUC = 0.88 in cross-validation). In prospective validation, the locked SVM maintained high accuracy (AUC = 0.984, 95 % CI 0.944–1.000; sensitivity = 0.88; specificity = 0.90) with good calibration (slope = 0.96; Brier = 0.098) and net clinical benefit across threshold probabilities of 0.1–0.7.</div></div><div><h3>Conclusion</h3><div>The optimized SVM model provides a reliable, data-driven approach for individualized ectasia-risk assessment in refractive surgery. By combining biomechanical and tomographic features, it enables early identification of high-risk patients and supports personalized surgical planning and postoperative monitoring. Further multi-center and long-term validation is warranted to enhance generalizability and clinical implementation.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105262"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo simulations of light-skin interactions: implications for therapeutic and oncological applications","authors":"Mahdi Qaryan ,&nbsp;Iman Kafian-Attari ,&nbsp;Isaac O. Afara","doi":"10.1016/j.pdpdt.2025.105251","DOIUrl":"10.1016/j.pdpdt.2025.105251","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Monte Carlo (MC) simulations are crucial tools for understanding light-skin interactions, which have significant applications in dermatology and oncology. This review provides foundational insights into light propagation in skin tissue, focusing on absorption, scattering, and optical properties to enhance therapeutic and diagnostic applications.</div></div><div><h3>Methods</h3><div>Articles were selected based on their relevance to Monte Carlo simulations of light-skin interactions, emphasizing their applications in therapeutic dermatology and cancer research. The selection process prioritized recent, high-quality studies and categorized them by spectral range, penetration depth, and Monte Carlo implementations to extract trends and insights.</div></div><div><h3>Results</h3><div>Existing MC simulation techniques and their clinical applications were analyzed through models of light distribution in multilayered skin. Various simulation approaches were explored, focusing on their ability to model therapeutic applications, including Photodynamic Therapy (PDT) and photothermal therapy (PTT). MC simulations also provide valuable insights into the optical characteristics of the skin tissue, including constituent-based optical variations, vascular modifications, and structural changes in cancerous tissues. This review also highlights key trends in the spectral ranges and penetration depths studied in the literature, as well as the prevalence and diversity of Monte Carlo implementations used for simulating light-skin interactions. These insights collectively demonstrate the precision and adaptability of MC methods in advancing diagnostic and therapeutic applications.</div></div><div><h3>Conclusions</h3><div>MC simulations provide a robust framework for advancing both cancer diagnostics and treatments. This review identifies current challenges, emerging trends, and future research directions, emphasizing the potential of MC simulations to revolutionize cancer care.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105251"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the invisible: In vivo imaging for photoaging therapies- review of the literature","authors":"Judit Korponai,&nbsp;Eva Remenyik,&nbsp;Emese Gellén","doi":"10.1016/j.pdpdt.2025.105298","DOIUrl":"10.1016/j.pdpdt.2025.105298","url":null,"abstract":"<div><h3>Background</h3><div>Photoaging refers to the cumulative structural and functional changes in the skin caused by chronic exposure to ultraviolet (UV) radiation, distinct from chronological (intrinsic) aging. Among available interventions, photodynamic therapy (PDT) has demonstrated not only anti-tumor efficacy but also skin rejuvenating effects. To evaluate treatment outcomes objectively, modern non-invasive imaging technologies are increasingly applied in dermatology. This review aims to summarize the use of in vivo imaging tools—Antera 3D, VISIA complexion analysis system, optical coherence tomography (OCT), and reflectance confocal microscopy (RCM)—to assess the clinical efficacy of PDT and other interventions for photoaging.</div></div><div><h3>Methods</h3><div>A PubMed search was conducted up to May 2024. Eligible studies included human participants, a minimum follow-up period of three months, treatment of photoaged facial or décolleté skin, and an objective assessment using one of the four imaging modalities. Seventeen studies fulfilled the inclusion criteria.</div></div><div><h3>Results</h3><div>The reviewed imaging modalities demonstrated complementary strengths. The Antera 3D and VISIA systems provide rapid and reproducible quantification of wrinkles, pigmentation, and vascular changes. OCT enables cross-sectional analysis of the epidermis and dermis, particularly collagen density and dermo-epidermal junction architecture. RCM offers near-histological resolution of epidermal and superficial dermal structures, capturing cellular and extracellular matrix changes. These modalities confirmed clinically visible improvements in photoaging after PDT and other rejuvenation procedures.</div></div><div><h3>Conclusion</h3><div>PDT and other interventions can partially reverse the clinical signs of photoaging. In vivo imaging tools enhance objectivity in treatment monitoring. A multimodal imaging approach may represent the future standard for both clinical and research settings.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105298"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for extramammary paget’s disease: A retrospective analysis of 15 cases","authors":"Feng Chen,&nbsp;Lingling Sun,&nbsp;Ruifang Zeng,&nbsp;Xiaohua Chen,&nbsp;Libo Li,&nbsp;Xiaojun Cai","doi":"10.1016/j.pdpdt.2025.105301","DOIUrl":"10.1016/j.pdpdt.2025.105301","url":null,"abstract":"<div><h3>Background</h3><div>Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. Photodynamic therapy (PDT) has shown promise as a treatment option for various skin cancers, including EMPD. This study aims to assess the clinical effectiveness of PDT in treating 15 cases of EMPD.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 15 patients diagnosed with EMPD in the Oncology Department of Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine from June 2014 to December 2024, all of whom received PDT as part of their treatment. According to the therapeutic regimens, patients were stratified into three cohorts: group A received systemic hematoporphyrin-derivative (HpD) PDT (with or without sequential ALA-PDT); group B underwent surgical excision followed by ALA-PDT as an adjunct; and group C was treated with ALA-PDT alone. Clinical outcomes, including lesion regression, recurrence rates, and adverse events, were evaluated during the follow-up period.</div></div><div><h3>Results</h3><div>The treatment of EMPD with PDT resulted in significant clinical improvement in most patients. Complete remission was achieved in 6 of 15 patients (40 %), partial remission was observed in 7 patients (46.7 %). In Group A, complete response was observed in 2 patients, partial response in 6 patients, and minimal response in 1 patient. All three patients in Group B achieved complete response. Group C had one patient in each category (CR 33 %, PR 33 %, MR 33 %). Treatment response was significantly more favourable in group B, in which all patients achieved a complete response (ordered logistic regression, <em>P</em> = 0.031; Group B vs Group A, OR = 18.0). However, among the six patients who achieved complete remission, four experienced disease recurrence during the subsequent follow-up period. The most common complaint was pain. Local infection and scarring were also observed in a small proportion of patients.</div></div><div><h3>Conclusions</h3><div>PDT shows promising results as a non-invasive treatment option for EMPD, providing a favorable balance between effectiveness and safety. The short-term efficacy of photodynamic therapy is highly encouraging; however, its long-term efficacy remains suboptimal. For patients who are unwilling or unsuitable for surgery, photodynamic therapy is a viable alternative. Although photodynamic therapy can achieve complete remission of lesions in some patients, its cure rate is relatively low, and there is a risk of recurrence. Further studies with larger sample sizes are needed to confirm these findings and investigate long-term outcomes.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105301"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bibliometric Analysis of the Global Research Landscape and Trends in Photoaging Therapy (2015–2024)","authors":"Ying Peng ,&nbsp;Qiong Gao ,&nbsp;Yibin Fan ,&nbsp;Yangyan Yi ,&nbsp;Yan Teng","doi":"10.1016/j.pdpdt.2025.105295","DOIUrl":"10.1016/j.pdpdt.2025.105295","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Skin photoaging, a degenerative skin process driven primarily by chronic ultraviolet radiation exposure, has become a key focus in dermatological research and clinical practice, with growing demand for effective preventive and therapeutic strategies. Despite the expansion of research in this field, no systematic bibliometric analysis has characterized the global research landscape of photoaging therapy over the past decade, leaving a gap in understanding its developmental trajectory.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We retrieved publications related to photoaging therapy from the Web of Science (WoS) Core Collection, with data searches and exports completed on August 26, 2025. The search covered literature published between January 1, 2015, and December 31, 2024, using the strategy: TS= (“skin photoaging” OR “photoaging” OR “photoaging of skin” OR “solar aging of skin”) AND TS= (therapy OR therapies OR treatment). After screening for publication timeframe (2015–2024), document types (articles and reviews), and language (English), 1172 eligible articles were included. Data analysis was performed using CiteSpace (Version 6.4.R1), VOSviewer (Version 1.6.20), Tableau (2025.2) and Excel (v2021) to examine annual publication trends, global distribution of research output, productivity and influence of countries, institutions, journals, and authors, collaborative networks, reference co-citations, and keyword co-occurrences.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Over the 2015–2024 period, research on photoaging therapy showed a steady upward trend in annual publications, increasing from 60 in 2015 to 199 in 2024 (a more than threefold growth). A total of 75 countries/regions, 1831 institutions, and 5860 authors contributed to the field. China led in publication volume (336 papers, 28.67%), followed by the United States (232 papers, 19.8%) and South Korea (231 papers, 19.71%), though China’s citation-per-publication rate (14.92) was relatively low. Among institutions, Kyung Hee University (South Korea) was the most productive (40 papers, 822 citations), while China Medical University (China) had the highest citation-per-publication ratio (29.32) among top institutions. The Journal of Cosmetic Dermatology published the most relevant papers (70), and the International Journal of Molecular Sciences had the highest total citations (1390, IF=4.9). Hwang, Eunson (21 papers) was the most productive author, with top authors predominantly affiliated with Kyung Hee University. Keyword co-occurrence analysis identified four core clusters: ultraviolet radiation-induced damage and mechanisms, photoaging-related skin diseases, prevention/treatment strategies, and pigmentation regulation/local therapies. Emerging research trends included the use of exosomes, microRNA, NF-κB signaling modulation, and platelet-rich plasma for regenerative repair.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This comprehensive bibliometric analysis quantifies the","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105295"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 50 % vs. 100 % intensity repeated low-level red-light on choroidal thickness and vasculature: A randomized crossover trial","authors":"Shiran Zhang ,&nbsp;Yanxian Chen ,&nbsp;Jian Zhang ,&nbsp;Zhuoting Zhu ,&nbsp;Xiaotong Han ,&nbsp;Meng Xuan ,&nbsp;Xiaohu Ding ,&nbsp;Ruilin Xiong ,&nbsp;Yixiong Yuan ,&nbsp;Yueye Wang ,&nbsp;Cong Li ,&nbsp;Lirong Liao ,&nbsp;Qiuxia Yin ,&nbsp;Yingfeng Zheng ,&nbsp;Xiangbin Kong ,&nbsp;Mingguang He","doi":"10.1016/j.pdpdt.2025.105240","DOIUrl":"10.1016/j.pdpdt.2025.105240","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine if 50 % repeated low-level red-light therapy (RLRL) can achieve the same choroidal thickening as the standard 100 % intensity, potentially reducing energy use without sacrificing efficacy in myopia control. This study aimed to investigate the daily choroidal thickness (ChT) and vasculature, as surrogate outcomes for myopia control efficacy, with the RLRL at 100 % and 50 % intensity.</div></div><div><h3>Methods</h3><div>This prospective crossover randomized controlled trial recruited adults aged 18–40 years with myopia. The study consisted of two 4-week treatment phases separated by a 4-week washout period, with participants randomly assigned to either a 100 %-50 % or 50 %-100 % RLRL treatment sequence. The primary outcomes were changes in subfoveal ChT (sfChT) and mean macular ChT (mChT) measured daily using swept-source optical coherence tomography. Secondary outcomes included macular choroidal vasculature.</div></div><div><h3>Results</h3><div>The study included 27 participants (mean age, 21.2 years). After 1 month of treatment, both 50 % and 100 % RLRL resulted in significant increases in sfChT, mChT, and peripapillary ChT, with no significant differences between the two groups. Choroidal thickening developed gradually over the treatment period, and daily change profiles in ChT and vasculature parameters were comparable.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that both 50 % and 100 % RLRL produced similar choroidal thickening, suggesting that 50 % RLRL may offer comparable myopia control efficacy with reduced energy usage.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105240"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Fire needle pretreatment combined with ALA-PDT for Penile Bowen’s disease: A case report\"","authors":"Meiyu Song","doi":"10.1016/j.pdpdt.2025.105264","DOIUrl":"10.1016/j.pdpdt.2025.105264","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 105264"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}