Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Tongue squamous cell carcinoma treated by 5-aminolevulinic acid administrated through Microdrop method","authors":"Yong Zhang ,&nbsp;Anqi Lyu ,&nbsp;Fang Zhang,&nbsp;Lingdi Zhao,&nbsp;Baozhen Ma,&nbsp;Quanli Gao","doi":"10.1016/j.pdpdt.2024.104308","DOIUrl":"10.1016/j.pdpdt.2024.104308","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative recurrence of tongue squamous cell carcinoma (TSCC) has always been a clinical problem for patients and doctors. Surgery and radiotherapy are the main treatment methods for TSCC, but reoperation often leads to functional impairment. Side effects of radiotherapy include mucosal gland damage, dry mouth, weakened or lost taste. Improved treatment is needed.</p></div><div><h3>Objective</h3><p>To evaluate the clinical outcome of a patient with TSCC treated with Microdrop aminolevulinic acid (ALA) photodynamic treatment (PDT) twice.</p></div><div><h3>Methods</h3><p>ALA was dissolved in 5 % lidocaine and the concentration of ALA was 20 % by Microdrop method. Then, the tumor tissue was expanded 1 cm outward, and the injection points were evenly distributed with an upper and lower left and right interval of 2–3 mm. The 1 ml syringe was used to perform the injection in the skin of the tumor area, and there was a small cuticle at each injection point. A pathologically confirmed patient with TSCC received twice Microdrop ALA-PDT treatments, which were evaluated at 1 month and 4 months later.</p></div><div><h3>Results</h3><p>After 3 h of Microdrop ALA injection, the wavelength of semiconductor laser was set to 630 nm, and the energy of 300 mW /cm² was irradiated for 30 min. After two treatments, the lesions were not visible, and no recurrence occurred after 4 months of follow-up. The patient's tongue function was well preserved and the cosmetic effect was good.</p></div><div><h3>Conclusion</h3><p>Microdrop ALA-PDT may be effective in the salvage treatment of select tongue squamous cell carcinoma.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104308"},"PeriodicalIF":3.1,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003454/pdfft?md5=dea3ee9730b381e4227a3fc230233309&pid=1-s2.0-S1572100024003454-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal vascular arcade angle in fundus image was associated with the rate of spherical equivalent refractive error and axial length changes in myopia children with young school age","authors":"Xuejing Mi ,&nbsp;Yuxin Fang ,&nbsp;Jianing Pu ,&nbsp;Wei Chen ,&nbsp;Zhen Zhou ,&nbsp;Mengmeng Qin ,&nbsp;Ranran Zhang ,&nbsp;Dan Wang ,&nbsp;Yanyan Yang ,&nbsp;Chuzhi Peng ,&nbsp;Shimeng Bian ,&nbsp;Mingrui Jin ,&nbsp;Huaying Xu ,&nbsp;Yonghong Jiao","doi":"10.1016/j.pdpdt.2024.104305","DOIUrl":"10.1016/j.pdpdt.2024.104305","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate temporal vascular arcade angle and its influencing factors in myopic children.</p></div><div><h3>Methods</h3><p>It was a retrospective study, we reviewed the records of 119 patients aged 6–10 years with myopia (spherical equivalent refractive error (SER) ≤ -0.05D) in the third year of follow-up in Beijing Hyperopia Reserve Research. We measured temporal vascular arcade angles on the fundus photographs and measured 3-year rate of spherical equivalent(D/year) and axial length (AXL) changes(mm/year).</p></div><div><h3>Results</h3><p>Mean age at initial visit was 7.71±1.20 years and mean SER was -1.32±1.09D. Children were divided into two groups according to the refractive status of children at baseline: Myopia onset group (SER&gt;-0.50D at baseline) (<em>n</em> = 107) and Myopia progression group (SER≤-0.50D at baseline) (<em>n</em> = 12). The mean SER in Myopia progression group was much smaller than Myopia onset group (<em>P</em> &lt; 0.001) and mean AXL in Myopia progression group was much longer than Myopia onset group (<em>P</em> = 0.042). AXL (<em>r</em>=-0.320, <em>P</em> &lt; 0.001), SER change rate (<em>r</em>=-0.209, <em>P</em> = 0.022) and AXL change rate (<em>r</em>=-0.232, <em>P</em> = 0.011) were associated with temporal vascular arcade angle in all participants. In Myopia onset group, AXL (<em>r</em>=-0.317, <em>P</em> &lt; 0.001) and AXL change rate (<em>r</em>=-0.190, <em>P</em> = 0.05) were associated with temporal vascular arcade angle. There were no parameters were associated with temporal vascular arcade angle (all <em>P</em> &gt; 0.05) in Myopia progression group. Only AXL (<em>r</em>=-0.306, <em>P</em> = 0.018) was associated with temporal vascular arcade angle in girls while AXL (<em>r</em>=-0.370, <em>P</em> = 0.004), SER change rate (<em>r</em>=-0.317, <em>P</em> = 0.013) and AXL change rate (<em>r</em>=-0.365, <em>P</em> = 0.004) were all associated with the Angle in boys.</p></div><div><h3>Conclusion</h3><p>Temporal vascular arcade angle was associated with the rate of SER and AXL changes in myopia onset children, and showed gender differences. These may suggest that lamina cribrosa location has different influencing factors in different genders and different stages of myopia development. Due to the small number of people in Myopia progression group, large sample size studies are still needed in the future.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104305"},"PeriodicalIF":3.1,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003429/pdfft?md5=84033b7255a3ea1629ee0ad881ce492a&pid=1-s2.0-S1572100024003429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of central corneal thickness measured in myopic eyes by Pentacam, Sirius and IOLMaster 700","authors":"Han Song ,&nbsp;Chengyang Liu ,&nbsp;Wei Yang ,&nbsp;Chunliu Yang ,&nbsp;Xiaodong Cheng","doi":"10.1016/j.pdpdt.2024.104302","DOIUrl":"10.1016/j.pdpdt.2024.104302","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to evaluate the correlations and consistency among the central corneal thickness (CCT) of healthy myopic patients measured with three different anterior segment analysis systems.</p></div><div><h3>Design</h3><p>This was a retrospective study. The study included myopia patients who had undergone preoperative examinations in the refractive surgery department of our hospital between January 2021 and December 2023. The CCT was measured separately using Pentacam, Sirius, and IOLMaster 700.</p></div><div><h3>Methods</h3><p>Statistical analysis was conducted using SPSS software. Correlations among the three groups of measured values were assessed using the Pearson method, and a simple scatter plot and fitting line were drawn. Bland‒Altman scatter plots and 95 % limits of agreement (LoAs) were used to evaluate consistency in the data among the systems.</p></div><div><h3>Results</h3><p>A total of 269 patients participated in the study, including 134 males (49.8 %) and 135 females (50.2 %). The CCT measurements by Pentacam, Sirius, and IOLMaster 700 instruments were found to be 541.63 ± 31.67 μm, 541.74 ± 33.36 μm, and 548.90 ± 34.19 μm respectively; significant differences were observed among these measurements (<em>p &lt;</em> 0.05). Significant differences were also observed in CCT between Pentacam and IOLMaster 700 as well as between Sirius and IOLMaster 700 (<em>p &lt;</em> 0.05). The CCT measurements by all three devices showed high positive correlation with all <em>p</em> values less than 0.001: Pentacam and Sirius, <em>r</em> = 0.972; Pentacam and IOLMaster 700, <em>r</em> = 0.966; and Sirius and IOLMaster 700, <em>r</em> = 0.962. The respective 95 % LoAs were -0.18∼0.18; -1.51∼-1.11; and -1.52∼-1.</p></div><div><h3>Conclusion</h3><p>The results indicate that there is a high correlation in measuring CCT for healthy myopic eyes using three different anterior segment analysis systems. However, the differences in the values measured by the three devices were statistically significant. Therefore, in actual clinical practice, it is suggested that the same device should be used to measure and evaluate the CCT across visits.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104302"},"PeriodicalIF":3.1,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003399/pdfft?md5=ce3ce962d1ce32c8d23745d294cc79c0&pid=1-s2.0-S1572100024003399-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful combined treatment with surgery and ALA-PDT for cutaneous infection by candida tropicalis: A case report and literature review","authors":"Xian He,&nbsp;Yuangang Lu","doi":"10.1016/j.pdpdt.2024.104303","DOIUrl":"10.1016/j.pdpdt.2024.104303","url":null,"abstract":"<div><p>Candidiasis is a common fungal infection, with Candida tropicalis infections being relatively rare. These infections develop into skin fungal infections under conditions such as broad-spectrum antibiotic use, diabetes, and immunosuppression. Traditionally, antifungal drugs have been the primary treatment; however, issues like hepatotoxicity and the need for long-term use persist. Consequently, new treatment approaches are essential. Most previous reports have focused on Candida albicans, with fewer addressing Candida tropicalis. This study reports a case where a patient with a skin Candida tropicalis infection was treated with a combination of surgery and ALA photodynamic therapy(635 nm, 120 J/cm², 177 mW/cm²). After just one session of this combined treatment, the patient achieved significant clinical remission. Therefore, the combination of surgery and ALA-PDT may offer a safe and effective treatment option.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104303"},"PeriodicalIF":3.1,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003405/pdfft?md5=ad3c993c74e615eaa987390d811c6dfe&pid=1-s2.0-S1572100024003405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Low-Level Laser Therapy in reducing postoperative pain after dental implant surgery: A randomized clinical trial","authors":"Javier Basualdo Allende ,&nbsp;Rodrigo Caviedes ,&nbsp;Alfredo von Marttens ,&nbsp;Francisca González Ramírez ,&nbsp;Iara Vargas Piña ,&nbsp;Milton Kuga ,&nbsp;Eduardo Fernández","doi":"10.1016/j.pdpdt.2024.104293","DOIUrl":"10.1016/j.pdpdt.2024.104293","url":null,"abstract":"<div><h3>Background</h3><p>A clinical trial was conducted to measure the effectiveness of a combined wavelength of 660 nm and 808 nm Low-Level Laser Therapy (LLLT) in reducing postoperative pain in partially and totally edentulous patients who underwent dental implant surgery.</p></div><div><h3>Materials and Methods</h3><p>The study included 20 blinded individuals divided in a randomized split-mouth fashion; the experimental group in one hemiarch and the control group in the other hemiarch. The experimental group received a total of 22.5 Joules (J) of LLLT divided into 5 points per implant immediately after surgery. The control group received a placebo treatment. At 24 h, 72 h, and 7 days, a blinded surveyor administered a pain questionnaire using a Numerical Rating Scale (NRS) combined with a Verbal Rating Scale (VRS) to assess pain onset after surgery, duration of the first pain episode, and pain evolution. Group data were analyzed with an ANOVA test for repeated measures and a paired <em>t</em>-test at defined time intervals.</p></div><div><h3>Results</h3><p>The experimental group showed a significant decrease in postoperative pain at 24 h and at 72 h for fully edentulous patients. There was a non-significant difference in the duration of the first pain episode. The mean pain levels decreased over time for both the experimental and control treatments, but only statistically significantly for the experimental group in the 24–72 h and 24 h to 7 days intervals. The same was true for the control group when comparing 24 and 72 h and between 24 h and 1 week. The time range between 72 h and 1 week showed no statistically significant differences.</p></div><div><h3>Conclusion</h3><p>Within the limitations of this study, a single dose of 22.5 J LLLT per implant helps to decrease postoperative pain in dental implant surgery at 24 h for partially edentulous patients and at 24 and 72 h for fully edentulous patients.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104293"},"PeriodicalIF":3.1,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003302/pdfft?md5=ea6e362f03ea397093cbe9e03e33130f&pid=1-s2.0-S1572100024003302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the retina and choroid in fibromyalgia patients and their correlation with disease severity and quality of life","authors":"Mariagrazia Avella,&nbsp;Alfredo Mignone","doi":"10.1016/j.pdpdt.2024.104301","DOIUrl":"10.1016/j.pdpdt.2024.104301","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104301"},"PeriodicalIF":3.1,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003387/pdfft?md5=c09cd5a0fea5ca5c9f59baa8850b7780&pid=1-s2.0-S1572100024003387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodiagnosis and Photodynamic Therapy (PD-PDT) Journal","authors":"","doi":"10.1016/j.pdpdt.2024.104222","DOIUrl":"10.1016/j.pdpdt.2024.104222","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"48 ","pages":"Article 104222"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002606/pdfft?md5=5cd0fb02f979535f098edaca20ab6875&pid=1-s2.0-S1572100024002606-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival of cancer patients after photobiomodulation therapy for prevention and treatment of oral mucositis","authors":"","doi":"10.1016/j.pdpdt.2024.104248","DOIUrl":"10.1016/j.pdpdt.2024.104248","url":null,"abstract":"<div><h3>Background</h3><p>Photobiomodulation therapy (PBMT) has been employed for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing treatment. However, information about the survival of patients receiving PBMT is still lacking. Therefore, the aim of this study was to correlate the survival of patients who either received or did not receive PBMT, combined with cancer treatments, and to assess whether the number of PBMT sessions had a positive impact on survival.</p></div><div><h3>Methods</h3><p>The records of 751 patients seen at Hospital de Caridade São Vicente de Paulo diagnosed with head and neck cancer, treated by D.L.P., the sole operator of PBMT, between 2000 and 2016, were analyzed. The median survival rates were compared by analyzing diagnostic staging, the combination of cancer treatments, and the number of PBMT sessions. Correlation analyses were performed to assess the interactions between the number of PBMT sessions and survival.</p></div><div><h3>Results</h3><p>PBMT increased survival by 55.14 %, from 1.07 (Without PBMT) to 1.66 years (With PBMT) for the total population and more significantly in Group 41 (stages III and IV, radiation therapy/chemotherapy, with more than five PBMT sessions), the median survival value of 1.83 years, which represents a 66.36 % higher survival rate. In all the analyzed populations, the larger number of sessions was associated with better survival. In terms of survival, advanced stages III and IV almost equated with stages I and II in the absence of PBMT.</p></div><div><h3>Conclusions</h3><p>PBMT seems to interfere with the survival of patients with head and neck cancer, corroborating its recommendation for the treatment of mucositis, but further research is needed to investigate possible synergistic effects between PBMT and cancer treatments.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"48 ","pages":"Article 104248"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024002850/pdfft?md5=af6693b62cb58a547157c3348dcf1c65&pid=1-s2.0-S1572100024002850-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting choroidal circulation parameters in 4–14-year-old Chinese children measured by SS-OCT/OCTA","authors":"Haoming Geng ,&nbsp;Jingyu Mu ,&nbsp;Juan Wen ,&nbsp;Weili Yao ,&nbsp;Luting Liu ,&nbsp;Chunmeng Liu ,&nbsp;Junguo Duan","doi":"10.1016/j.pdpdt.2024.104275","DOIUrl":"10.1016/j.pdpdt.2024.104275","url":null,"abstract":"<div><h3>Purpose</h3><p>To measure the choroidal circulatory parameters Han Chinese children aged 4–14 years from Southwest China, and to explore the relationships between these parameters and age, axial length (AL), and choroidal thickness (ChT).</p></div><div><h3>Methods</h3><p>284 eyes from 142 subjects were included in this cross-sectional study. All participants underwent cycloplegic refraction and IOLMaster500 examination. Swept-source optical coherence tomography (SS-OCT) was used to measure submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.</p></div><div><h3>Results</h3><p>In this population, the mean CVV was 2.92 ± 0.55 mm³, CSV was 4.69 ± 0.68 mm³, CVI was 38.22 ± 2.46 %, and CVV/CSV ratio was 62.11 ± 6.44 %. Multivariable regression analyses showed that both CVV and CSV were negatively correlated with AL (both <em>P</em> &lt; 0.001) and positively correlated with ChT (both <em>P</em> &lt; 0.001), while age showed no significant correlation with them (both <em>P</em> &gt; 0.05). However, the correlations between CVI and age were not uniform rectilinear. Among participants aged ≤8 years, CVI showed no correlation with age (<em>P</em> &gt; 0.05), while among those aged &gt;8 years, it was positively correlated with age (<em>P</em> &lt; 0.01). CVV/CSV ratio was positively correlated with ChT and age (both <em>P</em> &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>After the age of 8, age was positively correlated with CVI. ChT was well correlated with CVI. Longer AL and thinner ChT were associated with reduced CVV and CSV, with CVV decreasing more rapidly than CSV.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"48 ","pages":"Article 104275"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003120/pdfft?md5=6f8ca19835f5889fb339e8c725470621&pid=1-s2.0-S1572100024003120-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year results of central corneal stromal thickness reduction in small-incision lenticule extraction for high myopia correction","authors":"Xian Liu ,&nbsp;Qiang Liu ,&nbsp;Lan-hui Yu ,&nbsp;Rui Xiong ,&nbsp;Sheng-tao Liu ,&nbsp;Zhi-peng You","doi":"10.1016/j.pdpdt.2024.104278","DOIUrl":"10.1016/j.pdpdt.2024.104278","url":null,"abstract":"<div><h3>Background</h3><p>To investigate the long-term corneal stromal remodeling and central stromal thickness (CST) reduction accuracy after small-incision lenticule extraction (SMILE) for high myopia correction.</p></div><div><h3>Methods</h3><p>This prospective study included 30 patients (50 eyes) who had undergone SMILE. Measurements of CST reduction using optical coherence tomography were performed at 1 month, 6 months, 1 year, and 3 years after surgery. Correlations were performed between planned and achieved CST reductions.</p></div><div><h3>Results</h3><p>The study enrolled 50 eyes of 30 patients. The mean spherical equivalent was -9.25±1.52 D(diopters). The postoperative CST increased in the first month after surgery and remained stable for a year. Thereafter, it remained stable during follow-up from 1 to 3 years postoperatively. The predicted CST reduction was 146.4 ± 10.3 μm. The achieved CST reductions at 1 month, 6 months, 1 year, and 3 years after surgery were 135.3 ± 12.1 μm, 130.8 ± 10.6 μm, 125.9 ± 9.4 μm, and 122.2 ± 10.6 μm, respectively. An overestimation of CST reduction was observed three years after surgery. Correlation analysis revealed a strong correlation between planned and achieved CST reductions; however, no correlation was found between CST reductions predicted error and the planned CST reductions.</p></div><div><h3>Conclusion</h3><p>During long-term follow-up, our findings revealed a significant stromal remodeling following SMILE in patients with high myopia. Therefore, clinicians should consider it when screening patients with high myopia for SMILE.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"48 ","pages":"Article 104278"},"PeriodicalIF":3.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003156/pdfft?md5=344829c632505c6a2b299c79568cd7c4&pid=1-s2.0-S1572100024003156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}