Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Assessment of systemic reaction to inflammation induced by photodynamic therapy in cervical intraepithelial neoplasia","authors":"Nasrulla Shanazarov ,&nbsp;Tatyana Grishacheva ,&nbsp;Alisher Aitkaliyev ,&nbsp;Zhanara Salmaganbetova ,&nbsp;Sandugash Smailova ,&nbsp;Balkenzhe Imankulova ,&nbsp;Maxim Afanasiev ,&nbsp;Alexander Dushkin","doi":"10.1016/j.pdpdt.2024.104416","DOIUrl":"10.1016/j.pdpdt.2024.104416","url":null,"abstract":"<div><div>Photodynamic therapy is a curative treatment of human papillomavirus-associated diseases that provides a selective effect leading to the destruction of pathological cells containing the virus. The retrospective study aimed to determine the role of systemic inflammatory reaction induced by photodynamic stimulation in low- and high-squamous intraepithelial lesion treatment.</div></div><div><h3>Methods</h3><div>143 patients with confirmed human papillomavirus-associated cervical intraepithelial neoplasia underwent photodynamic therapy with Photolon and activation in the range of 662 nm. All patients underwent colposcopy, histologic study, HPV DNA analysis, CBC, and immunogram. The chi-square criterion was used to evaluate differences before, 5 days post, and 3 months after PDT; a P value &lt;0.05 was considered significant.</div></div><div><h3>Results</h3><div>A complete regression in patients with low-squamous intraepithelial lesion (n=117) was achieved 3 months after PDT in 89.7% of cases (105/117) while it persisted in 12 patients. Complete regression in patients with high-squamous intraepithelial lesion (n=26) was achieved in 92.3% (24/26), one patient retained with the lesion, and another one had partial regression in the form of lower grade lesion. On the 5th day post-PDT, the formation of dense fibrin in photodynamic effect was noted on colposcopy, and changes in CBC, accompanied by statistically significant neutrocytosis, increased ESR and other indicators of reactive inflammation were recorded. Patients noted increased body temperature up to 37.8±0.5°C in 88% of cases.</div></div><div><h3>Conclusion</h3><div>One of the mechanisms of PDT`s antitumor and antiviral action is the development of acute inflammation in response to cytotoxic action on cells and vascular response in the form of pathological area devascularization. Such reactive inflammation activates all parts of the immune system. Changes on day 5 post-PDT in inflammatory parameters in CBC and IL-1, IL-6 and TNF-α markers correlate with the clinical picture of the post-photodynamic effect.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104416"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid diagnosis of latent and active pulmonary tuberculosis by autofluorescence spectroscopy of blood plasma combined with artificial neural network algorithm","authors":"Fengjiao Yue ,&nbsp;Si Li ,&nbsp;Lijuan Wu ,&nbsp;Xuerong Chen ,&nbsp;Jianhua Zhu","doi":"10.1016/j.pdpdt.2024.104426","DOIUrl":"10.1016/j.pdpdt.2024.104426","url":null,"abstract":"<div><div>The existing clinical diagnostic methods of pulmonary tuberculosis (TB) usually have some of the following limitations, such as time-consuming, invasive, radioactive, insufficiently sensitive and accurate. This study demonstrates the possibility of using blood plasma autofluorescence spectroscopy and Artificial Neural Network (ANN) algorithm for the rapid and accurate diagnosis of latent and active pulmonary TB from healthy subjects. The fluorescence spectra of blood plasma from 18 healthy volunteers, 12 individuals with latent TB infections and 80 active TB patients are measured and analyzed. By optimizing the ANN structure and activation functions, the ANN three-classification model achieves average classification accuracy of 96.3 %, and the accuracy of healthy persons, latent TB infections and active TB patients are 100 %, 83.3 % and 97.5 %, respectively, which is much better than the results of traditional Principal component analysis (PCA) and Linear discriminant analysis (LDA) method. To the best of our knowledge, this is the first research work of differentiating latent, active pulmonary TB cases from healthy samples with autofluorescence spectroscopy. As a rapid, accurate, safe, label-free, non-invasive and cost-effective technique, it can be developed as a promising diagnostic tool for the screening of pulmonary TB disease in the early stage.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104426"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity assessment of a third-generation light-induced fluorescence device in detecting proximal and occlusal caries lesions: Correspondence","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.pdpdt.2024.104420","DOIUrl":"10.1016/j.pdpdt.2024.104420","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104420"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for oral mucositis in cancer patients- a systematic review and meta-analysis","authors":"Betsy Joseph ,&nbsp;Matti Mauramo ,&nbsp;Baiju Kamalasanan Vijayakumary ,&nbsp;Tuomas Waltimo ,&nbsp;Sukumaran Anil ,&nbsp;Timo Sorsa","doi":"10.1016/j.pdpdt.2024.104424","DOIUrl":"10.1016/j.pdpdt.2024.104424","url":null,"abstract":"<div><h3>Aim</h3><div>This systematic review aimed to evaluate the efficacy of photodynamic therapy (PDT) in reducing the severity of chemotherapy-induced oral mucositis, and associated symptoms in cancer patients compared to standard care or other interventions.</div></div><div><h3>Materials and methods</h3><div>A comprehensive literature search identified seven relevant studies (randomized controlled trials and non-randomized clinical trials) published between January 1, 2000, and May 31, 2024. The data analysis was carried out using the standardized mean difference as the outcome measure. A random-effects model was fitted to the data. The rank correlation test and the regression test, using the standard error of the observed outcomes as predictors, were used to check for funnel plot asymmetry.</div></div><div><h3>Results</h3><div>Studies combining PDT with photobiomodulation therapy (PBMT) consistently showed superior therapeutic outcomes compared to PBMT alone, particularly in accelerating healing and reducing pain. In the meta-analysis (<em>k</em> = 4), the observed standardized mean differences ranged from -0.9605 to -0.0223, with most estimates being negative (100 %). The estimated average standardized mean difference based on the random-effects model was -0.5138 (95% CI: -0.8799 to -0.1477).</div></div><div><h3>Conclusion</h3><div>PDT, especially when combined with PBMT, shows promise in reducing the severity of oral mucositis and associated symptoms in cancer patients.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104424"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates","authors":"Jian Zhang ,&nbsp;Youlin Zhu ,&nbsp;Ping Yuan ,&nbsp;Xiaojuan Dong ,&nbsp;Manyun Xie ,&nbsp;Zongrui Ma ,&nbsp;Rong Tian","doi":"10.1016/j.pdpdt.2024.104408","DOIUrl":"10.1016/j.pdpdt.2024.104408","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the correlations of spherical equivalent (SE), axial length (AL), and AL to corneal curvature radius ratio (AL/CR) with anterior segment biometrics in candidates for myopic refractive surgery.</div></div><div><h3>Methods</h3><div>Anterior segment biometrics of 2,478 myopic refractive surgery candidates measured by Pentacam were collected retrospectively. The anterior segment biometrics included anterior corneal curvature (ACC), posterior corneal curvature (PCC), white-to-white corneal diameter (WTW), central corneal thickness (CCT), corneal volume at 3 mm (CV), anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), anterior corneal eccentricity (ACE), posterior corneal eccentricity (PCE), anterior corneal asphericity (ACAP), posterior corneal asphericity (PCAP), anterior chamber depth (ACD), and anterior chamber volume (ACV). The eyes were divided into four groups according to the AL: group 1, AL≤24 mm; group 2, 24mm&lt;AL≤26 mm; group 3, 26mm&lt;AL≤28 mm; group 4, AL≥28mm. The correlations between these biometrics with SE, AL, and AL/CR were assessed by Pearson or Spearman correlation tests. A correlation with a coefficient ≥0.3 and a p value &lt;0.05 were considered significant.</div></div><div><h3>Results</h3><div>In all AL groups, ACC was positively correlated with SE (<em>r</em> = 0.446 to 0.620) and negatively correlated with AL/CR (<em>r</em> = -0.704 to -0.894), whereas PCC was positively correlated with SE (<em>r</em> = 0.394 to 0.612) and negatively correlated with AL/CR (<em>r</em> = -0.606 to -0.787). WTW was positively correlated with SE (<em>r</em> = 0.304 to 0.474) in every group, and negatively correlated with AL/CR (<em>r</em> = -0.405 and -0.412) in group 1 and 4. ACA was positively correlated with AL (<em>r</em> = 0.310) and AL/CR (<em>r</em> = -0.333) in group 4. ACD was negatively correlated with AL (<em>r</em> = -0.304) in group 4, and positively correlated with AL/CR (<em>r</em> = -0.325) in group 2. ACV was positively correlated with SE (<em>r</em> = 0.344) in group 4, and positively correlated with AL (<em>r</em> = 0.303) in group 2. CCT, CV, PCA, ACE, PCE, ACAP, and PCAP was not significantly correlated with SE, AL, or AL/CR in any of group.</div></div><div><h3>Conclusions</h3><div>Differential correlations were observed between anterior segment biometrics and SE, AL, and AL/CR, suggesting that various myopia indicators have different effects on ocular structures. These findings may help identify the ocular structures that can be targeted of refractive surgery.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104408"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hiporfin photodynamic therapy for early-stage cervical cancer: A case report","authors":"Yu Liu ,&nbsp;Ruifang Wu ,&nbsp;Changzhong Li ,&nbsp;Mingmei Li ,&nbsp;Hao Li ,&nbsp;Lihui Wei ,&nbsp;Ruizhen Li","doi":"10.1016/j.pdpdt.2024.104422","DOIUrl":"10.1016/j.pdpdt.2024.104422","url":null,"abstract":"<div><div>A 28-year-old female patient, diagnosed with stage IA1 cervical cancer, received PDT treatment with intravenous injection of Hiporfin, a HpD type photosensitizer. The patient's human papillomavirus (HPV) and cytology testing results were negative at the 3-month. At 6 months, the lesions on the cervical surface and within the cervical canal had completely resolved. There were no signs of recurrence or HPV infection during the 12-month follow-up period. There were no serious adverse events reported during or after the PDT treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104422"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon nanodots as photosensitizer in photodynamic inactivation of Rickettsia slovaca","authors":"Yevheniy-Yuliy Peresh ,&nbsp;Katarína Šoltys ,&nbsp;Ľuboš Kľúčár ,&nbsp;Gábor Beke ,&nbsp;Mária Kováčová ,&nbsp;Zdenko Špitalský ,&nbsp;Eva Špitalská","doi":"10.1016/j.pdpdt.2024.104402","DOIUrl":"10.1016/j.pdpdt.2024.104402","url":null,"abstract":"<div><div>Carbon quantum dots (CQDs) are promising therapeutic agent due to their pro-oxidant, antioxidant, antiviral, antibacterial, and anticancer properties when exposed to visible light irradiation. Oxidative stress in bacteria is the main reason for bacteria death after exposure to blue light photoexcited quantum dots. Herein, we present the antibacterial activities of hydrophobic carbon quantum dots/polydimethylsiloxane nanocomposites, hydrophilic citric acid CQDs, and combinations of CQDs with methylene blue. We investigated the antirickettsial effect of hydrophilic and hydrophobic CQDs against <em>Rickettsia slovaca</em>, a tick-borne bacterial pathogen. Photodynamic activity against on rickettsiae reached 99.66% using CQDs with 470 nm blue light irradiation. Combining methylene blue with CQDs further enhanced the effect on rickettsial infection, achieving 99,98% efficacy. The obtained results reveal the in vitro antirickettsial properties of CQDs. Sequencing analysis on the genomic level of control and treated samples showed single nucleotide variants (SNVs). Based on snippy analysis SNVs were assigned to the <em>rRNA</em> genes, <em>16S rRNA</em> and <em>30S rRNA</em> genes. By freebayes analysis in treated samples, a stop-lost mutation was detected in pseudogene (RSL_RS06070), while the possible effect on down-stream genes including <em>tsaD</em>, acyl-CoA-desaturase, 30S ribosomal protein S6 and DUF424 family protein. The frameshift mutation was localized within <em>clpB</em> pseudogene belonging to stress-response heat-shock proteins.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104402"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generational shift for clinical application of the QLF system for evaluating tooth wear","authors":"Sang-Kyeom Kim,&nbsp;Eun-Song Lee,&nbsp;Baek-Il Kim","doi":"10.1016/j.pdpdt.2024.104413","DOIUrl":"10.1016/j.pdpdt.2024.104413","url":null,"abstract":"<div><h3>Background</h3><div>No study has quantitatively assessed tooth wear using a clinical quantitative light-induced fluorescence (QLF) system. This study aimed to compare fluorescence parameters (ΔF_wear) between the research QLF system (QLF-D) and clinical QLF system (Qraycam Pro) and evaluate the validity of both systems in detecting dentin exposure from tooth wear.</div></div><div><h3>Methods</h3><div>Thirty-five human molars and premolars were collected. Two blinded examiners conducted evaluations. Images from QLF-D and Qraycam Pro were captured and analyzed by the first examiner to calculate ΔF_wear, representing the maximum fluorescence intensity for occlusal wear. The stage of tooth wear was determined by the second examiner using the tooth wear index (TWI). The area of interest (AOI) was determined as the cusp without defects, such as caries or fractures. Only areas mutually agreed by both examiners were included in analysis. The Kruskal-Wallis test was conducted to assess differences in ΔF_wear between two devices. ROC analysis evaluated the validity of both systems in determining dentin exposure using AUROC.</div></div><div><h3>Results</h3><div>Thirty-eight AOIs were analyzed. ΔF_wear significantly increased with higher TWI scores. Median ΔF_wear for TWI scores (0, 1, and 2) were 6.9 %, 10.3 %, and 24.8 %, respectively, for QLF-D, and 5.7 %, 7.7 %, and 23.9 %, respectively, for Qraycam Pro. No significant differences in ΔF_wear were observed between QLF-D and Qraycam Pro for any TWI score. The AUROC for both systems was 0.95.</div></div><div><h3>Conclusion</h3><div>ΔF_wear was comparable between QLF-D and Qraycam Pro and demonstrated high validity in detecting dentin exposure. These findings support the clinical application of the QLF for quantitative tooth wear assessment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104413"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of repeated low-level red-light exposure on choroidal thickness and blood flow in pediatric patients: A SS-OCTA study","authors":"Huihang Wang ,&nbsp;Huifen Zhong ,&nbsp;Jingjin Zhang ,&nbsp;Wei Wei ,&nbsp;Xiaoyuan Cui ,&nbsp;Weidong Zheng","doi":"10.1016/j.pdpdt.2024.104412","DOIUrl":"10.1016/j.pdpdt.2024.104412","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the impact of repeated low-level red-light (RLRL) therapy on choroidal thickness and blood flow in pediatric myopia.</div></div><div><h3>Methods</h3><div>A three-month trial (April 1, 2023 – September 30, 2023) was conducted involving 44 children (ages 6–16) with myopia. Participants underwent RLRL therapy at home twice daily for five days per week, with each session lasting three minutes. Assessments at baseline, one month, and three months included cycloplegic refraction, best-corrected visual acuity (BCVA), intraocular pressure (IOP), ocular biometrics, swept-source optical coherence tomography angiography (SS-OCTA), slit-lamp, and fundus examinations.</div></div><div><h3>Results</h3><div>The study included 44 children (average age: 9.79 years; 56.82 % male). RLRL therapy significantly increased subfoveal choroidal thickness (Baseline: 272.82 ± 64.01 μm; 1-month: 297.77 ± 72.94 μm; 3-month: 298.77 ± 77.17 μm, <em>p</em> = 0.001), reduced axial length (Baseline: 24.97 ± 1.47 mm; 3-month: 24.88 ± 1.38 mm, <em>p</em> = 0.002), and showed a marginal regression in spherical equivalent (<em>p</em> = 0.055). Significant elevations in choroidal vessel volume and thickness were noted, with positive correlations intensifying with distance from the fovea.</div></div><div><h3>Conclusion</h3><div>RLRL therapy shows promise in managing pediatric myopia by increasing choroidal vessel volume and thickness, potentially mitigating myopia progression.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104412"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished retinal microcirculation in mild preeclampsia without obvious retinopathy in high-altitude native Tibetans by OCTA","authors":"Chong Tang ,&nbsp;Shuren Pan ,&nbsp;Xiangfang Zeng ,&nbsp;Xinlu Fu ,&nbsp;Jiaxuan Deng ,&nbsp;Kai Shi","doi":"10.1016/j.pdpdt.2024.104396","DOIUrl":"10.1016/j.pdpdt.2024.104396","url":null,"abstract":"<div><h3>Background</h3><div>To investigate the retinal microcirculation in mild preeclampsia (PE) without obvious retinopathy in high-altitude native Tibetans by optical coherence tomography angiography (OCTA).</div></div><div><h3>Methods</h3><div>This study enrolled 64 mild preeclamptic pregnant women without retinopathy (group PPW), 63 healthy pregnant women (group HPW), and 61 healthy non-pregnant women (group HNPW). All participants were high-altitude native Tibetans who underwent OCTA, retinal thickness (RT), vascular density (VD), perfusion density (PD) and foveal avascular zone (FAZ) parameters were measured in the macula. Differences in these parameters among the groups were compared, and the correlations of these parameters with blood pressure were evaluated.</div></div><div><h3>Results</h3><div>In the entire macula, VD and PD were significantly lower in group PPW than in group HPW and HNPW (<em>p</em> &lt; 0.05). In the subregions, VD was significantly different in fovea, parafovea and perifovea, PD was significantly different in parafovea and perifovea among the three groups (<em>p</em> &lt; 0.05), the further pairwise comparisons showed VD and PD in parafovea and perifovea were lower in group PPW than in group HPW, and VD and PD in perifovea were lower in group PPW than in group HNPW (<em>p</em> &lt; 0.05). RT and FAZ parameters did not differ among the groups (<em>P</em> &gt; 0.05). VD and PD exhibited negative correlations with SBP and DBP (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>OCTA can objectively evaluate diminished microcirculation in mild PE without obvious retinopathy among high-altitude native Tibetans, and provide a crucial time window for early screening of PE-induced retinopathy.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"50 ","pages":"Article 104396"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}