Photodiagnosis and Photodynamic Therapy最新文献

{"title":"Efficacy and safety of fluorescence navigation combined with 3D imaging in precise liver resection: A systematic review and meta-analysis","authors":"Chunwei Xu,&nbsp;Xinhua Cui,&nbsp;Jiafei Che,&nbsp;Xiaojing Shen,&nbsp;Dingchao Chen","doi":"10.1016/j.pdpdt.2024.104446","DOIUrl":"10.1016/j.pdpdt.2024.104446","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness and safety of fluorescence navigation combined with three-dimensional imaging (FN&amp;3DI) technology in precise liver resection.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases for all English-language publications on fluorescence-guided navigation combined with three-dimensional (3D) imaging technology–assisted precise liver resection, with a cutoff date of July 2024. After assessing the quality of the included studies and extracting relevant data, a meta-analysis was performed using Stata 12.0 software.</div></div><div><h3>Results</h3><div>A total of 6 studies involving 451 patients were included in this study, with 207 patients in the FN&amp;3DI group and 244 patients in the conventional surgery (CS) group. The meta-analysis results showed that the FN&amp;3DI group exhibited significantly lower values than the CS group in terms of intraoperative blood loss [mean difference (MD) = –97.90, 95 % confidence intervals (CI) = –151.15 to –44.66, <em>P</em> = 0.000], intraoperative blood transfusion rates [odds ratios (OR) = 2.96, 95 % CI = 1.71–5.10, <em>P</em> = 0.000], hospital stay (MD = –0.91, 95 % CI = –1.78 to –0.04, <em>P</em> = 0.041), and overall postoperative complications (OR = 1.68, 95 % CI = 1.11 to 2.53, <em>P</em> = 0.014). However, the FN&amp;3DI group exhibited significantly longer surgery time (MD = 57.36, 95 % CI = 13.31–101.40, <em>P</em> = 0.011), but no statistically significant difference was noted in conversion rate, R0 resection margins, and postoperative recurrence between the two groups.</div></div><div><h3>Conclusion</h3><div>Fluorescence navigation combined with 3D imaging technology is safe and feasible for guiding precise liver resection.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104446"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating choroidal vascular changes in young adults with high myopia utilizing swept source optical coherence tomography angiography","authors":"Qing wang ,&nbsp;Lin-Bo He ,&nbsp;Sha Li ,&nbsp;Hong-Ling Liu ,&nbsp;Yong Liu","doi":"10.1016/j.pdpdt.2025.104475","DOIUrl":"10.1016/j.pdpdt.2025.104475","url":null,"abstract":"<div><h3>Purpose</h3><div>Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in the vascular characteristics of the choriocapillaris and larger vascular layers, including Sattler's and Haller's layers, in the macular region of young myopia patients, in order to Enhance our comprehension of the underlying mechanisms of the pathogenesis of myopia.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 103 young adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL &lt; 26.5 mm as non-high myopia (NHM) and 90 eyes with AL ≥ 26.5 mm as high myopia (HM). Macular superficial capillary plexuses (SCP), deep capillary plexuses (DCP), choriocapillaris (CC) density, choroidal Sattler's and Haller's layers (CSHL) density, foveal avascular zone area (FAZ area), and subfoveal choroidal thickness (SFCT) were assessed. Multivariate regression analysis was employed to assess the effect of age,spherical equivalent(SE), axial length(AL),and SFCT on OCTA parameters.</div></div><div><h3>Results</h3><div>SCP and DCP densities in the foveal retina of NHM group were significantly lower than those in HM group(SCP 20.09 ± 4.30 vs. 21.54 ± 4.52, <em>p</em> = 0.043;DCP14.73 ± 3.93 vs. 16.21 ± 4.07, <em>p</em> = 0.024). Also, CC density subfoveal was significantly lower in NHM group compared to HM group(55.02 ± 2.39 vs. 56.37 ± 2.76, <em>p</em> = 0.0001); CSHL density subfoveal and parafoveal temporal were also significantly lower in NHM than HM(subfoveal 55.78 ± 4.67 vs. 58.17 ± 4.41, <em>p</em> = 0.002;parafoveal temporal 52.10 ± 3.48 vs. 54.06 ± 4.12, <em>p</em> = 0.002). In the multiple linear regression analysis, density of SCP in the foveal retina was increased with higher myopia(sβ=0.226, <em>p</em> = 0.047)and decreased with aging(sβ=-0.304, <em>p</em> = 0.001). Moreover, gradual decrease of the DCP was observed with aging(sβ=-0.227, <em>p</em> = 0.004). CSHL density subfoveal increased with the increase in AL(sβ=0.318, <em>p</em> = 0.007).</div></div><div><h3>Conclusion</h3><div>Age primarily influenced retinal vessel density, whereas axial length significantly affected Sattler's and Haller's layers. This also indicates that the subfoveal and parafoveal temporal CSHL densities are crucial for monitoring changes during myopia progression. Additionally, there appears to be a compensatory mechanism for high myopia to sustain visual function.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104475"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal vascular parameters in patients with type 2 diabetes mellitus","authors":"Isabella Pellegrino,&nbsp;Mariagrazia Avella","doi":"10.1016/j.pdpdt.2024.104423","DOIUrl":"10.1016/j.pdpdt.2024.104423","url":null,"abstract":"","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104423"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wood's lamp for early detection of Microsporum Canis tinea capitis in children","authors":"Dexiang Sun ,&nbsp;Jinming Lu ,&nbsp;Tao Liu ,&nbsp;Jun Wang","doi":"10.1016/j.pdpdt.2024.104428","DOIUrl":"10.1016/j.pdpdt.2024.104428","url":null,"abstract":"<div><h3>Background</h3><div>Pediatric alopecia is increasingly common, influenced by conditions like alopecia areata and infections such as tinea capitis, primarily caused by <em>Microsporum canis</em>. Diagnosing tinea capitis in primary care is challenging due to limited access to advanced tools, leading to treatment delays.</div></div><div><h3>Objectives</h3><div>This study evaluates the effectiveness of Wood's lamp for early diagnosis of tinea capitis and its role in distinguishing it from other pediatric alopecia types.</div></div><div><h3>Methods</h3><div>Fifty pediatric patients under 12 with alopecia were enrolled from March 2023 to March 2024. Data collected included contact history, CFW microscopy, fungal cultures, Wood's lamp examinations, treatments, and follow-ups.</div></div><div><h3>Results</h3><div>Wood's lamp identified 22 cases linked to animal contact, confirmed as <em>Microsporum canis</em>. Overall, 30 tinea capitis, 15 alopecia areata, and 5 trichotillomania cases were diagnosed. Post-treatment, fluorescence decreased in tinea capitis patients, who also showed hair regrowth, with no recurrence during follow-up.</div></div><div><h3>Conclusions</h3><div>Wood's lamp is a valuable, cost-effective diagnostic tool for tinea capitis, especially when combined with animal contact history, supporting its use in primary healthcare.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104428"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caries affected Dentin biomodification using Bromelain, Riboflavin photosensitizer via UVA, and Chitosan Nanoparticles on shear bond strength and microleakage scores: A SEM evaluation","authors":"Khold Alahdal,&nbsp;Ahmed Maawadh,&nbsp;Laila AlDeeb,&nbsp;Thamer Almohareb,&nbsp;Ahoud S Alshamrani,&nbsp;Ali Alrahlah","doi":"10.1016/j.pdpdt.2024.104419","DOIUrl":"10.1016/j.pdpdt.2024.104419","url":null,"abstract":"<div><h3>Aims</h3><div>Assessment of the impact of different dentin bio-modifiers i.e., Bromelain, Riboflavin photosensitizer (RFP/Ultraviolet-A), and Chitosan nanoparticles (CHNPs) on the shear bond strength (SBS) and microleakage of composite bonded to acid etched carious affected dentin (CAD).</div></div><div><h3>Materials and methods</h3><div>Sixty-four human molars in which carious lesions extend till the middle third of the dentin were included. The infected dentin was removed and CAD was exposed. All specimens were categorized into four groups based on the application of dentin bio-modifier (<em>n</em> = 16) Group 1 (No dentin modifier), Group 2 (Bromelain), Group 3 (RFP/UVA), and Group 4 (CHNPs). Dental adhesive application and composite buildup were performed. A dye penetration test was used to assess marginal leakage. Resin CAD interface assessment was performed using SEM. For SBS and failure pattern analysis, a universal testing machine and stereomicroscope were used respectively. One-way ANOVA followed by Bonferroni's posthoc test was employed to analyze the differences among various groups <em>(p</em> <em>≤</em> <em>0.05)</em></div></div><div><h3>Results</h3><div>The lowest microleakage (13.27 ± 0.10) and highest SBS (11.64 ± 0.16 MPa) were observed in Group 2 (Bromelain). However, the maximum values of marginal leakage (37.21 ± 0.21) and minimum SBS (7.34 ± 0.07 MPa) were detected in Group 1 samples. The length of resin tags in the Group 2 specimens (Bromelain) was found to be the highest (102.11 ± 5.12 μm)^. However, Group 1 (No modifier) exhibited the lowest resin tag length (50.45 ± 2.37 μm).</div></div><div><h3>Conclusion</h3><div>Caries-affected dentin modified with Bromelain resulted in satisfactory SBS with minimal microleakage scores. Chitosan nanoparticles and RFP/Ultraviolet-A also presented better outcomes in terms of microleakage and SBS than the control.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104419"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma","authors":"Nan Yang ,&nbsp;Yunchuan Yang ,&nbsp;Wanqi Zhang,&nbsp;Xinying Li,&nbsp;Hao Jiang,&nbsp;Huiling Kou,&nbsp;Junbo Zhang,&nbsp;Yuanyuan Wang,&nbsp;Liuchang Tan,&nbsp;Yuangang Lu","doi":"10.1016/j.pdpdt.2024.104469","DOIUrl":"10.1016/j.pdpdt.2024.104469","url":null,"abstract":"<div><h3>Background</h3><div>Cutaneous squamous cell carcinoma (cSCC) is an aggressive tumor with unclear margins. Photodynamic diagnosis (PDD) enables the differentiation of tumor tissue from normal tissue via visible fluorescence. Photodynamic therapy (PDT) is widely used in the treatment of non-melanoma skin tumors. This study aims to illustrate the efficacy and safety of PDD-guided tumor excision combined with ALA-PDT in patients with cSCC.</div></div><div><h3>Methods</h3><div>This study involved 23 cSCC patients, randomly assigned to the PDD group (<em>n</em> = 11) and the non-PDD group (<em>n</em> = 12). Patients in the PDD group underwent tumor excision guided by PDD, while those in the non-PDD group received wide local excision (WLE). Both groups were subjected to frozen section analysis, and PDT was applied during and post-surgery.</div></div><div><h3>Results</h3><div>The negative margin rate in the PDD group was 98.6 %, significantly higher than the 69.2 % observed in the non-PDD group. The PDD group required fewer frozen section analyses and experienced reduced surgical duration.</div></div><div><h3>Conclusions</h3><div>PDD effectively delineates tumor margins in cSCC, guiding the scope of surgical excision. The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104469"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study","authors":"Yun Wu ,&nbsp;Qing Fan ,&nbsp;Xiaojing Liu ,&nbsp;Yajing Cao ,&nbsp;Jin Yang ,&nbsp;Yu Yan ,&nbsp;Hui Tao ,&nbsp;Fuhe Zhang ,&nbsp;Linglin Zhang ,&nbsp;Peiru Wang ,&nbsp;Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104474","DOIUrl":"10.1016/j.pdpdt.2025.104474","url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea.</div></div><div><h3>Methods</h3><div>In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up.</div></div><div><h3>Results</h3><div>A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in <em>Demodex</em> mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed.</div></div><div><h3>Conclusions</h3><div>STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104474"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypocrellin A-mediated photodynamic antibacterial activity against Cutibacterium acnes: An in vitro study","authors":"Muqiu Zhang ,&nbsp;Xinyao Liu ,&nbsp;Xin Ran ,&nbsp;Runyan Gao ,&nbsp;Jitong Sun ,&nbsp;Kaiwen Zhuang ,&nbsp;Zimeng You ,&nbsp;Zhi Zhang ,&nbsp;Yuping Ran","doi":"10.1016/j.pdpdt.2024.104467","DOIUrl":"10.1016/j.pdpdt.2024.104467","url":null,"abstract":"<div><div>Skin dysbiosis caused by <em>Cutibacterium acnes</em> contributes greatly to the complex pathogenesis of acne, and antimicrobial photodynamic therapy (PDT) has emerged as a promising treatment option for acne treatment. Hypocrellin, a photosensitizer extracted from a traditional Chinese medicinal fungus, has showed effective antimicrobial activity. This study aimed to evaluate the antibacterial ability of hypocrellin mediated PDT against <em>Cutibacterium acnes.</em> Using modified broth dilution method and morphological observation, the antibacterial effect was tested under a series of experimental conditions. The results showed that hypocrellin initiates type II photodynamic reactions by inducing amount of reactive oxygen species, particularly singlet oxygen. Within a certain concentration range, hypocrellin effectively maintained the antibacterial efficacy with minimal damage to keratinocyte cells. These results provide new insights into the use of PDT for acne treatment.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104467"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of one-year real-world outcomes between red (670 nm) subthreshold micropulse laser treatment and intravitreal aflibercept injection for treatment-naïve diabetic macular edema","authors":"Wataru Kikushima,&nbsp;Yukiko Furuhata,&nbsp;Taiyo Shijo,&nbsp;Mizuki Matsumoto,&nbsp;Yoichi Sakurada,&nbsp;Daphne Viel Tsuru,&nbsp;Kenji Kashiwagi","doi":"10.1016/j.pdpdt.2024.104430","DOIUrl":"10.1016/j.pdpdt.2024.104430","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the treatment outcomes of subthreshold micropulse laser (SMPL) with a wavelength of 670 nm (red) for treatment-naïve diabetic macular edema (DME).</div></div><div><h3>Methods</h3><div>A retrospective observational study which included 42 eyes in 34 patients diagnosed with treatment-naïve DME was conducted. Twenty-one eyes underwent red SMPL and the other 21 eyes underwent intravitreal injection of aflibercept (IVA) as initial treatment and were followed up for 12 months. Best-corrected visual acuity (BCVA), central retinal thickness (CRT) on optical coherence tomography (OCT), vessel density (VD), and foveal avascular zone area on OCT angiography (OCTA) were measured and compared between the two groups.</div></div><div><h3>Results</h3><div>In the red SMPL group, the mean BCVA slightly improved from 0.29 ± 0.28 at baseline to 0.22 ± 0.29 at 12 months (<em>p</em> = 0.18), while the mean CRT significantly decreased from 472 ± 200 µm at baseline to 320 ± 136 µm at 12 months (<em>p</em> = 0.003). At 12 months from baseline, the mean change in BCVA and CRT were similar between the red SMPL and IVA groups (<em>p</em> = 0.79 and <em>p</em> = 0.31, respectively). No significant change was detected in OCTA parameters except for VD at the nasal section in the red SMPL group.</div></div><div><h3>Conclusion</h3><div>Red SMPL for treatment-naïve DME maintained BCVA and significantly reduced CRT at 12 months. These treatment outcomes were equivalent to IVA in real-world settings, which tend to be inferior to clinical trials.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104430"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of retinal and choroidal vascular changes via optical coherence tomography angiography between pseudoexfoliative glaucoma and pseudoexfoliation syndrome and control group","authors":"Mohammad Hossein Ahoor,&nbsp;Rana Sorkhabi,&nbsp;Farhad Najafzadeh,&nbsp;Sheyda Mahmoudzadeh,&nbsp;Amin Arasteh,&nbsp;Tahereh Attar Gharamaleki","doi":"10.1016/j.pdpdt.2024.104444","DOIUrl":"10.1016/j.pdpdt.2024.104444","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to evaluate the differences in retinal and choroidal vasculature using optical coherence tomography angiography (OCTA) in patients with pseudoexfoliative glaucoma (PEX-G) and patients with pseudoexfoliation syndrome without glaucoma (PEX-S) and the control group.</div></div><div><h3>Materials and Methods</h3><div>In this cross-sectional study, 25 patients with PEX-G, 27 PEX-S cases, and 25 patients as the control group (C) were evaluated. All patients and the control group underwent macular and optic nerve head (ONH) OCTA, performed using the Optovue device. The foveal and parafoveal vascular density (VD) in superficial capillary plexus (SCP) and deep capillary plexus (DCP), foveal avascular zone (FAZ) area, outer retina flow area, choriocapillaris flow area, peripapillary VD, and retinal nerve fiber layer (RNFL) thickness in the macula and peripapillary region were assessed.</div></div><div><h3>Results</h3><div>77 eyes of 77 patients were included. The mean foveal SCP VD in the control group was 9.62 % and 8.92 % higher than in the PEX-S and PEX-G groups; the median foveal DCP VD had 11.3 % and 13.2 % higher values in the controls. The PEX-S and PEX-G groups showed no differences regarding the macular microvasculature. The intradisc VD and the peripapillary VD were 7.5 % and 17.9 % lower in the PEX-G group compared to the controls. Besides, the peripapillary VD was significantly correlated with the RNFL thickness (R²:0.789, p:&lt;0.0001).</div></div><div><h3>Conclusion</h3><div>In patients with PEX, regardless of glaucoma, the retinal VD showed deficiencies compared to the controls. Also, the peripapillary VD was strongly correlated with the RNFL thickness. These findings mean that retinal vascular changes might precede the development of glaucoma in PEX syndrome and can even be its cause.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104444"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}