Photobiomodulation and orthodontic root resorption: A systematic review and meta-analysis

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-05-30 DOI:10.1016/j.pdpdt.2025.104659

Jing Yang, Qianqian Zhang, Dehua Zheng, Fengchun Hou

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引用次数: 0

Abstract

Objectives

Orthodontically induced inflammatory root resorption (OIIRR) is a common adverse effect of orthodontic treatment, characterized by the reduction in root length and volume. Photobiomodulation (PBM), a non-invasive method, has gained attention for its potential in controlling OIIRR. This review aims to analyze and summarize randomized controlled trials (RCTs) to evaluate the impact of PBM on root resorption during orthodontic treatment in humans.

Methods

A systematic search was conducted using relevant keywords in the Cochrane Library, PubMed, EMBASE, Web of Science, and ScienceDirect for studies published up to January 2025. Studies were selected based on predefined inclusion and exclusion criteria. The Cochrane Risk of Bias tool (RoB 2) was used to assess the risk of bias in the included RCTs. A meta-analysis was performed using RevMan software (version 5.4), and subgroup analyses were conducted to identify sources of heterogeneity.

Results

Eight studies with a total of 185 participants were included in the analysis. The forest plot results demonstrated that LED interventions led to statistically significant improvements in root resorption (MD = –0.15, [95 % CI –0.19, –0.10], p < 0.00001). While LLLT studies indicated a trend toward reduced root resorption, the results did not reach statistical significance (SMD = –1.69, [95 % CI –3.52, 0.14], p = 0.07). The overall change in root length was not statistically significant, except for the canine tooth, where a significant reduction in resorption was observed (MD = –0.49, 95 % CI [–0.95, –0.03], p = 0.04). Subgroup analysis indicated that a wavelength of 850 nm or longer, a fluence exposure greater than 10 J/cm², irradiance less than 25 mW/cm², treatment durations exceeding two minutes, and more than six treatment sessions were associated with a beneficial effect in reducing orthodontically induced inflammatory root resorption.

Conclusion

In conclusion, while photobiomodulation (PBM) appears to have a beneficial effect on orthodontically induced root resorption, the current body of evidence is limited, with a low number of studies and considerable heterogeneity. These findings are exploratory and require validation through high-quality trials with robust designs, standardized methods, and longer follow-ups.

Registration

PROSPERO registration number - CRD42023444677.

Abstract Image

查看原文本刊更多论文

光生物调节和正畸牙根吸收：系统综述和meta分析。

目的：正畸诱导炎症性牙根吸收（OIIRR）是正畸治疗中常见的不良反应，其特征是牙根长度和体积减少。光生物调节（PBM）作为一种非侵入性的方法，因其在控制OIIRR方面的潜力而受到关注。本综述旨在分析和总结随机对照试验（rct），以评估PBM对人类正畸治疗中牙根吸收的影响。方法：系统检索Cochrane Library、PubMed、EMBASE、Web of Science和ScienceDirect等相关关键词，检索截止到2025年1月发表的研究。根据预先确定的纳入和排除标准选择研究。采用Cochrane偏倚风险工具（RoB 2）评估纳入的随机对照试验的偏倚风险。采用RevMan软件（version 5.4）进行meta分析，并进行亚组分析以确定异质性来源。结果：8项研究共185名参与者被纳入分析。森林样地结果表明，LED干预导致根系吸收的改善具有统计学意义（MD = -0.15,[95% CI -0.19, -0.10], p < 0.00001）。虽然LLLT研究显示了根吸收减少的趋势，但结果没有达到统计学意义（SMD = -1.69,[95% CI -3.52, 0.14], p = 0.07）。牙根长度的总体变化无统计学意义，但犬牙的吸收明显减少（MD = -0.49,95% CI [-0.95, -0.03], p = 0.04）。亚组分析表明，波长为850 nm或更长，辐照量大于10 J/cm²，辐照度小于25 mW/cm²，治疗时间超过2分钟，治疗时间超过6次，与减少正畸诱导的炎症根吸收的有益效果相关。结论：综上所述，虽然光生物调节（PBM）似乎对正畸诱导的牙根吸收有有益的影响，但目前的证据有限，研究数量少，异质性大。这些发现是探索性的，需要通过高质量的试验、可靠的设计、标准化的方法和更长的随访来验证。报名：普洛斯彼罗注册号- CRD42023444677。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.