5-氨基乙酰丙酸光动力疗法治疗难治性外阴硬化性地衣的主观疗效分析。

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-21 DOI:10.1016/j.pdpdt.2025.104768

Guiqin Chen , Yicheng Li , Jingyi Mu , Zhenzhen Lu , Lei Cao , Xin Cheng , Yue Wang

{"title":"5-氨基乙酰丙酸光动力疗法治疗难治性外阴硬化性地衣的主观疗效分析。","authors":"Guiqin Chen , Yicheng Li , Jingyi Mu , Zhenzhen Lu , Lei Cao , Xin Cheng , Yue Wang","doi":"10.1016/j.pdpdt.2025.104768","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in refractory Vulvar lichen sclerosus (VLS) patients. <strong><em>Methods</em></strong><em>:</em> This prospective study enrolled a total of 60 patients with refractory VLS. These patients received 6 sessions of ALA-PDT treatment. Follow-ups were conducted at 3, 6 and 12 months after treatment to evaluate the improvement of patients' subjective symptom and objective clinical signs. In addition, the Dermatology Life Quality Index (DLQI) was used to assess the quality of life (QoL) of patients after treatment.</div></div><div><h3>Results</h3><div>Significant reductions were observed in both itching and burning pain scores post-treatment (p < 0.05). Objective clinical signs also demonstrated marked improvement (p < 0.01). At 12 months after treatment, 53 of 60 patients (88.33%) achieved clinically significant response (defined as ≥50% reduction in symptom scores). The DLQI score decreased from 20 points before treatment to 4, 2, and 3, indicating enhanced QoL. Most adverse reactions were mild and resolved with supportive care.</div></div><div><h3>Conclusion</h3><div>ALA-PDT represents a promising therapeutic alternative for refractory VLS, offering sustained symptom relief and objective clinical improvement with a favorable safety profile.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"56 ","pages":"Article 104768"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of subjective efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of refractory vulvar lichen sclerosus\",\"authors\":\"Guiqin Chen , Yicheng Li , Jingyi Mu , Zhenzhen Lu , Lei Cao , Xin Cheng , Yue Wang\",\"doi\":\"10.1016/j.pdpdt.2025.104768\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This study evaluated the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in refractory Vulvar lichen sclerosus (VLS) patients. <strong><em>Methods</em></strong><em>:</em> This prospective study enrolled a total of 60 patients with refractory VLS. These patients received 6 sessions of ALA-PDT treatment. Follow-ups were conducted at 3, 6 and 12 months after treatment to evaluate the improvement of patients' subjective symptom and objective clinical signs. In addition, the Dermatology Life Quality Index (DLQI) was used to assess the quality of life (QoL) of patients after treatment.</div></div><div><h3>Results</h3><div>Significant reductions were observed in both itching and burning pain scores post-treatment (p < 0.05). Objective clinical signs also demonstrated marked improvement (p < 0.01). At 12 months after treatment, 53 of 60 patients (88.33%) achieved clinically significant response (defined as ≥50% reduction in symptom scores). The DLQI score decreased from 20 points before treatment to 4, 2, and 3, indicating enhanced QoL. Most adverse reactions were mild and resolved with supportive care.</div></div><div><h3>Conclusion</h3><div>ALA-PDT represents a promising therapeutic alternative for refractory VLS, offering sustained symptom relief and objective clinical improvement with a favorable safety profile.</div></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"56 \",\"pages\":\"Article 104768\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S157210002500300X\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S157210002500300X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：评价5-氨基乙酰丙酸光动力疗法（ALA-PDT）治疗难治性外阴硬化性地衣（VLS）的疗效。方法：本前瞻性研究共纳入60例难治性VLS患者。这些患者接受了6次ALA-PDT治疗。分别于治疗后3、6、12个月进行随访，评估患者主观症状及客观临床体征的改善情况。此外，采用Dermatology Life Quality Index （DLQI）评价治疗后患者的生活质量（QoL）。结果：治疗后瘙痒和灼痛评分均显著降低（p < 0.05）。客观临床症状也有明显改善（p < 0.01）。治疗12个月后，60例患者中有53例（88.33%）达到临床显著缓解（定义为症状评分降低≥50%）。DLQI评分由治疗前的20分下降到4分、2分和3分，表明生活质量提高。大多数不良反应是轻微的，并通过支持性护理解决。结论：ALA-PDT是治疗难治性VLS的一种有希望的替代治疗方法，具有持续的症状缓解和客观的临床改善，且具有良好的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Analysis of subjective efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of refractory vulvar lichen sclerosus

Objective

This study evaluated the therapeutic effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in refractory Vulvar lichen sclerosus (VLS) patients. Methods: This prospective study enrolled a total of 60 patients with refractory VLS. These patients received 6 sessions of ALA-PDT treatment. Follow-ups were conducted at 3, 6 and 12 months after treatment to evaluate the improvement of patients' subjective symptom and objective clinical signs. In addition, the Dermatology Life Quality Index (DLQI) was used to assess the quality of life (QoL) of patients after treatment.

Results

Significant reductions were observed in both itching and burning pain scores post-treatment (p < 0.05). Objective clinical signs also demonstrated marked improvement (p < 0.01). At 12 months after treatment, 53 of 60 patients (88.33%) achieved clinically significant response (defined as ≥50% reduction in symptom scores). The DLQI score decreased from 20 points before treatment to 4, 2, and 3, indicating enhanced QoL. Most adverse reactions were mild and resolved with supportive care.

Conclusion

ALA-PDT represents a promising therapeutic alternative for refractory VLS, offering sustained symptom relief and objective clinical improvement with a favorable safety profile.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.