Retinal curvature in myopia: correlation with ocular physiological parameters

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-21 DOI:10.1016/j.pdpdt.2025.104771

Siyu Yang, Ruibing Sun, Nan Xu, Lijiao Lu, Danyang Wang, Mingzhe Cao

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引用次数: 0

Abstract

Purpose

Investigate the correlation of retinal curvature (RC) with ocular physiological parameters in myopic eyes.

Method

Clinical data from 332 patients (447 myopic eyes) were retrospectively analyzed. Eyes were classified into low myopia (LM), moderate myopia (MM), and high myopia (HM) groups based on spherical equivalent (SE) and axial length (AL). Ultra-widefield sweptsource optical coherence tomography (UWF-SS-OCT) was used to acquire 24 × 20 mm OCT scans. Bruch’s membrane segmentation and AL-based correction produced a 3D retinal model. RC maps derived top curvature values (RC-MAX, RC-MID, RC-MIN) averaged as RC-AVE. Angiography quantified retinal vessel density (RVD), subfoveal choroidal thickness (SFCT), and choroidal parameters (CVI: choroidal vessel index; CSV/a: choroidal stromal volume per unit area; CVV/a: choroidal vascular volume per unit area) in macular and optic disc areas.

Results

RC-AVE decreased with myopia severity: LM: 1.02 (0.89, 1.14) × 10⁻²mm⁻², MM: 0.93 (0.83, 1.12) × 10⁻²mm⁻², HM: 0.76 (0.67, 0.90) × 10⁻²mm⁻². RC exhibited a significant negative correlation with AL (β = - 3.15, p < 0.001) and significant positive correlations with SE (β = 5.34, p < 0.001) and SFCT (β = 56.61, p = 0.001). In the macular region, RC positively correlated with choroidal vascular parameters CSV/a and CVV/a (β = 30.62, p = 0.005; β = 18.67, p = 0.002). In the optic disc region, RC showed significant positive associations with CVI, CSV/a, and CVV/a (β = 3.66, p < 0.001; β = 49.56, p < 0.001; β = 38.04, p < 0.001).

Conclusion

RC can quantitatively characterize retinal shape and the morphological changes induced by myopia. Significantly reduced RC in high myopia, with RC exhibiting negative correlations with AL and positive correlations with SE, SFCT, and vascular parameters.

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近视视网膜曲率：与眼部生理参数的相关性。

目的：探讨近视眼视网膜曲率与眼生理参数的相关性。方法：回顾性分析332例（447只眼）近视患者的临床资料。根据眼球体当量（SE）和眼轴长度（AL）将眼睛分为低近视（LM）、中度近视（MM）和高度近视（HM）组。使用超宽视场扫描源光学相干断层扫描（UWF-SS-OCT）获得24张 × 20 mm OCT扫描图。Bruch的膜分割和基于al的校正产生了三维视网膜模型。RC地图得到的顶曲率值（RC- max, RC- mid, RC- min）平均为RC- ave。血管造影量化黄斑和视盘区域视网膜血管密度（RVD）、中央凹下脉络膜厚度（SFCT）和脉络膜参数（CVI：脉络膜血管指数；CSV/a：单位面积脉络膜间质体积；CVV/a：单位面积脉络膜血管体积）。结果：RC-AVE随近视严重程度降低：LM: 1.02（0.89, 1.14） × 10-2mm-2, MM: 0.93（0.83, 1.12） × 10-2mm-2, HM: 0.76（0.67, 0.90） × 10-2mm-2。RC与AL呈显著负相关（β = - 3.15,p < 0.001），与SE呈显著正相关（β = 5.34,p < 0.001），与SFCT呈显著正相关（β = 56.61,p = 0.001）。在黄斑区，RC与脉络膜血管参数CSV/a和CVV/a呈正相关（β = 30.62,p = 0.005;β = 18.67,p = 0.002）。在视盘区，RC与CVI、CSV/a、CVV/a呈显著正相关（β = 3.66,p < 0.001; β = 49.56,p < 0.001; β = 38.04,p < 0.001）。结论：RC能定量表征近视视网膜的形态变化。高度近视患者RC显著降低，RC与AL呈负相关，与SE、SFCT和血管参数呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.