病理性近视萎缩性黄斑孔的临床特征：一项多中心研究。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-06-13 DOI:10.1016/j.pdpdt.2025.104680

Hai-Long He , Guang-Qi An , Yue Qi , Xiao-Bing Yu , Ming-Wei Zhao , Zong-Ming Song , Xue Min Jin , Li-Ping Du , Zi-Bing Jin

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引用次数: 0

摘要

目的：描述并分析病理性近视（PM）患者的严重并发症萎缩性黄斑孔（AMH）的临床特征。方法：对2023年1月至2023年12月诊断为AMH的17例患者（17眼）和诊断为PM单纯性黄斑孔（SMH）的52例患者（52眼）进行多中心回顾性分析。收集临床资料和多模态图像。描述AMH患者的年龄、性别、球形当量（SE）、轴向长度（AL）、最佳矫正视力（BCVA），并分析其影像学特征。结果：17例确诊AMH患者中，女性15例（88.24%）；平均年龄64.59±12.61岁；SE为-17.85±4.15 D；AL为30.40±1.67 mm；BCVA为1.30 (1.00,1.35)logMAR。11眼（64.71%）出现近视视网膜裂孔，7眼出现脉络膜新生（Fuchs斑），1眼合并视网膜前膜，未见累及黄斑的视网膜脱离。轴长和新生血管形成是AMH患者BCVA的显著相关因素（P0.05）。结论：我们提出“萎缩性黄斑裂孔”一词来描述一种类似黄斑裂孔并伴有RPE和脉络膜萎缩的疾病，这种疾病由外视网膜进行性变性或眼球牵拉引起，严重损害患者的中心视力。

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Clinical characteristics of atrophic macular hole in pathologic myopia: A multicenter study

Purpose

This study aims to describe and analyze the clinical characteristics of atrophic macular hole (AMH), a severe complication in patients with pathologic myopia (PM).

Methods

A multicenter, retrospective analysis was conducted involving 17 patients (17 eyes) diagnosed with AMH and 52 patients (52 eyes) diagnosed with simple macular hole (SMH) in PM from January 2023 to December 2023. Clinical data and multimodal images were collected. The age, gender, spherical equivalent (SE), axial length (AL), and best-corrected visual acuity (BCVA) of patients with AMH were described and their imaging characteristics analyzed.

Results

Of the 17 patients diagnosed with AMH, 15 (88.24 %) were female; the mean age was 64.59±12.61 years; the SE was -17.85±4.15 D; the AL was 30.40±1.67 mm; and the BCVA was 1.30 (1.00, 1.35) logMAR. Eleven eyes (64.71 %) exhibited myopic foveoschisis, seven eyes showed choroidal neovascularization (Fuchs spot), one eye had a concomitant epiretinal membrane, and no cases of retinal detachment involving the macula were observed. Axial length and neovascularization were significant correlates of BCVA in AMH patients (P < 0.05). Compared with SMH in PM, patients with AMH were older (t = 2.247, P = 0.028) and had worse BCVA (Z = 375, P = 0.037); no significant differences were found between the two groups in terms of gender, SE, and AL (P > 0.05).

Conclusion

We propose the term “atrophic macular hole” to describe a condition resembling a macular hole accompanied by atrophy of the RPE and choroid, caused by progressive degeneration of the outer retina or traction of the eyeball, which severely impairs central vision in patients.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.