后葡萄肿的角膜生物力学。

IF 2.6
Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu
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引用次数: 0

摘要

目的:应用角膜显像技术(Corvis ST)比较有无后路葡萄肿(PS)眼的角膜生物力学差异。方法:这是一个横断面研究。将患者分为PS组和对照组。采用Corvis ST测量角膜生物力学参数,比较两组及不同PS亚型之间的差异。结果:本研究纳入PS组和对照组各40例。调整轴向长度(AL)后,PS组最大凹度变形幅值(HCDA)、最大凹度挠度幅值、最大挠度幅值(DLA max)和2mm处变形幅值比max均显著高于PS组。匹配AL后,PS组只有HCDA和DLA max显著高于AL组。不同亚型PS的角膜生物力学参数差异无统计学意义,A2 V、PD、Radius、HCDA、HCDLL、HCDLA、A2DLA、DLAmax、HC dArc Length、A2 dArc Length、dArc Length Max、DA Ratio Max、Integrated Radius与PS显著相关,在区分PS时,DLA Max具有最高的诊断效能,其受试者工作特征曲线下面积(AUROC)为0.79 (95% CI,0.71 ~ 0.85);性别与年龄合并后所有资料的ROC曲线下面积为0.813(95%CI:0.74 ~ 0.88)。结论:后路葡萄肿(PS)的角膜变形性、弹性和粘弹性均高于对照组,与后路葡萄肿的位置无关。这些发现提示PS影响眼前壁,为PS的发病机制提供了新的思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The corneal biomechanics of the posterior staphyloma.

Purpose: To compare the corneal biomechanical differences of eyes with and without posterior staphyloma (PS) using Corneal Visualization Scheimpflug Technology (Corvis ST).

Methods: This is a cross-sectional study. The patients were classified into the PS group and control group. Corneal biomechanical parameters were measured by Corvis ST and compared between the two groups and among different PS subtypes.

Results: This study included 40 patients in the PS group and the control group respectively. The deformation amplitude at the highest concavity (HCDA), deflection amplitude at the highest concavity, max deflection amplitude (DLA max) and deformation amplitude ratio max at 2mm were significant higher in the PS group after adjusting the axial length (AL). After matching the AL, only the HCDA and DLA max were significantly greater in the PS group. There was no significant difference in corneal biomechanical parameters among the subtype PS. The A2 V, PD, Radius, HCDA, HCDLL, HCDLA, A2DLA, DLAmax, HC dArc Length, A2 dArc Length, dArc Length Max, DA Ratio Max, Integrated Radius are significantly correlated with PS. In distinguishing PS, DLA Max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.79 (95% CI,0.71-0.85), meanwhile, the area under the ROC curve of all data after the combination of gender and age was 0.813(95%CI:0.74-0.88).

Conclusion: Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pathogenesis.

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