Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu
{"title":"后葡萄肿的角膜生物力学。","authors":"Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu","doi":"10.1016/j.pdpdt.2025.105231","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare the corneal biomechanical differences of eyes with and without posterior staphyloma (PS) using Corneal Visualization Scheimpflug Technology (Corvis ST).</p><p><strong>Methods: </strong>This is a cross-sectional study. The patients were classified into the PS group and control group. Corneal biomechanical parameters were measured by Corvis ST and compared between the two groups and among different PS subtypes.</p><p><strong>Results: </strong>This study included 40 patients in the PS group and the control group respectively. The deformation amplitude at the highest concavity (HCDA), deflection amplitude at the highest concavity, max deflection amplitude (DLA max) and deformation amplitude ratio max at 2mm were significant higher in the PS group after adjusting the axial length (AL). After matching the AL, only the HCDA and DLA max were significantly greater in the PS group. There was no significant difference in corneal biomechanical parameters among the subtype PS. The A2 V, PD, Radius, HCDA, HCDLL, HCDLA, A2DLA, DLAmax, HC dArc Length, A2 dArc Length, dArc Length Max, DA Ratio Max, Integrated Radius are significantly correlated with PS. In distinguishing PS, DLA Max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.79 (95% CI,0.71-0.85), meanwhile, the area under the ROC curve of all data after the combination of gender and age was 0.813(95%CI:0.74-0.88).</p><p><strong>Conclusion: </strong>Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pathogenesis.</p>","PeriodicalId":94170,"journal":{"name":"Photodiagnosis and photodynamic therapy","volume":" ","pages":"105231"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The corneal biomechanics of the posterior staphyloma.\",\"authors\":\"Xiqiong Liao, Guanshun Yu, Yi Jiang, Xiaoyu Zhuang, Shumeng Yao, Kaige Li, Shuhan Yu, Yi Wang, Qi Dai, Lin Fu\",\"doi\":\"10.1016/j.pdpdt.2025.105231\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To compare the corneal biomechanical differences of eyes with and without posterior staphyloma (PS) using Corneal Visualization Scheimpflug Technology (Corvis ST).</p><p><strong>Methods: </strong>This is a cross-sectional study. The patients were classified into the PS group and control group. Corneal biomechanical parameters were measured by Corvis ST and compared between the two groups and among different PS subtypes.</p><p><strong>Results: </strong>This study included 40 patients in the PS group and the control group respectively. The deformation amplitude at the highest concavity (HCDA), deflection amplitude at the highest concavity, max deflection amplitude (DLA max) and deformation amplitude ratio max at 2mm were significant higher in the PS group after adjusting the axial length (AL). After matching the AL, only the HCDA and DLA max were significantly greater in the PS group. There was no significant difference in corneal biomechanical parameters among the subtype PS. The A2 V, PD, Radius, HCDA, HCDLL, HCDLA, A2DLA, DLAmax, HC dArc Length, A2 dArc Length, dArc Length Max, DA Ratio Max, Integrated Radius are significantly correlated with PS. In distinguishing PS, DLA Max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.79 (95% CI,0.71-0.85), meanwhile, the area under the ROC curve of all data after the combination of gender and age was 0.813(95%CI:0.74-0.88).</p><p><strong>Conclusion: </strong>Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pathogenesis.</p>\",\"PeriodicalId\":94170,\"journal\":{\"name\":\"Photodiagnosis and photodynamic therapy\",\"volume\":\" \",\"pages\":\"105231\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and photodynamic therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.pdpdt.2025.105231\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and photodynamic therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.pdpdt.2025.105231","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The corneal biomechanics of the posterior staphyloma.
Purpose: To compare the corneal biomechanical differences of eyes with and without posterior staphyloma (PS) using Corneal Visualization Scheimpflug Technology (Corvis ST).
Methods: This is a cross-sectional study. The patients were classified into the PS group and control group. Corneal biomechanical parameters were measured by Corvis ST and compared between the two groups and among different PS subtypes.
Results: This study included 40 patients in the PS group and the control group respectively. The deformation amplitude at the highest concavity (HCDA), deflection amplitude at the highest concavity, max deflection amplitude (DLA max) and deformation amplitude ratio max at 2mm were significant higher in the PS group after adjusting the axial length (AL). After matching the AL, only the HCDA and DLA max were significantly greater in the PS group. There was no significant difference in corneal biomechanical parameters among the subtype PS. The A2 V, PD, Radius, HCDA, HCDLL, HCDLA, A2DLA, DLAmax, HC dArc Length, A2 dArc Length, dArc Length Max, DA Ratio Max, Integrated Radius are significantly correlated with PS. In distinguishing PS, DLA Max achieved the highest diagnostic performance, with an area under the receiver operating characteristic curve (AUROC) of 0.79 (95% CI,0.71-0.85), meanwhile, the area under the ROC curve of all data after the combination of gender and age was 0.813(95%CI:0.74-0.88).
Conclusion: Eyes with posterior staphyloma (PS) exhibit greater corneal deformability, elasticity, and viscoelasticity than controls, independent of PS location. These findings suggest PS impacts the anterior ocular wall, offering insights into PS pathogenesis.