Comparative Analysis of Anterior and Posterior Segment Parameters in the Fellow Eye of Unilateral Pseudoexfoliation Glaucoma.

IF 2.6
Zeynep Duru, Mutluay Bozoklu
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Abstract

Purpose: This study aimed to investigate structural and microvascular changes in affected and clinically unaffected fellow eyes of patients with unilateral pseudoexfoliation glaucoma (PEG), and compared with healthy controls.

Methods: In this prospective, cross-sectional study, 30 patients with unilateral PEG and 27 age-matched controls underwent ocular biometry, corneal tomography, specular microscopy, swept-source optical coherence tomography (SS-OCT), and OCT angiography (OCT-A). Central corneal thickness, anterior chamber depth and angle, lens thickness, pupil diameter, chord mu, axial length, and endothelial cell density, peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell layer-inner plexiform layer (GCL-IPL), lamina cribrosa thickness (LCT) and depth (LCD), Bruch's membrane opening distance (BMO-D), subfoveal choroidal thickness (SFCT), and macular superficial capillary plexus vessel density (SCP VD) were evaluated.

Results: Anterior segment parameters were largely similar across PEG, fellow, and control eyes, except for a slightly shallower anterior chamber in PEG eyes (p=0.032). PEG eyes showed significantly reduced RNFL and GCL-IPL thickness compared with fellow and control eyes, while fellow eyes were comparable to controls. LCT was thinner in PEG eyes, whereas LCD, BMO-D, and SFCT showed no differences. OCT-A revealed reduced SCP VD in inferior, nasal, and temporal quadrants of PEG eyes, with preserved foveal perfusion. Fellow eyes did not demonstrate significant vascular changes.

Conclusion: PEG eyes exhibit pronounced structural and microvascular compromise, while anterior segment parameters remain mostly preserved. Clinically unaffected fellow eyes are similar to healthy controls, highlighting the asymmetric clinical manifestation of pseudoexfoliation. SS-OCT and OCT-A offer valuable insight into early glaucomatous damage in PEG.

单侧假脱落性青光眼同侧眼前后段参数的比较分析。
目的:本研究旨在探讨单侧假脱落性青光眼(PEG)患者的结构和微血管变化,并与健康对照进行比较。方法:在这项前瞻性横断面研究中,30例单侧PEG患者和27例年龄匹配的对照组接受了眼部生物测量、角膜断层扫描、镜面显微镜、扫源光学相干断层扫描(SS-OCT)和OCT血管造影(OCT- a)。评估角膜中央厚度、前房深度和角度、晶状体厚度、瞳孔直径、索目数、轴向长度、内皮细胞密度、乳头周围视网膜神经纤维层(RNFL)、黄斑神经节细胞层-内丛状层(GCL-IPL)、筛层厚度(LCT)和深度(LCD)、Bruch膜开口距离(BMO-D)、中央凹下脉络膜厚度(SFCT)、黄斑浅层毛细血管丛血管密度(SCP VD)。结果:除了PEG眼的前房略浅(p=0.032)外,PEG眼、同眼和对照眼的前段参数基本相似。与对照组和对照组相比,PEG组的眼RNFL和GCL-IPL厚度显著降低,而对照组的眼与对照组相当。LCT在PEG眼中较薄,而LCD、BMO-D和SFCT无差异。OCT-A显示PEG眼下、鼻和颞象限的SCP VD减少,中心凹灌注保留。其他眼睛没有明显的血管改变。结论:聚乙二醇眼表现出明显的结构和微血管损伤,而前节参数基本保留。临床未受影响的眼睛与健康对照相似,突出了假性去角质的不对称临床表现。SS-OCT和OCT-A对PEG的早期青光眼损伤提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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