Distribution and Determinants of Lens Biometrics in Cataract Patients: Insights from Biometrics and Implications for Surgical Precision.

IF 2.6
Chunwen Zheng, Ruirui Ma, Xiaoning Hao, Wenwen Geng, Ling Jin, Yijun Hu
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Abstract

Objectives: To investigate the distribution patterns of lens-specific biometrics, including lens thickness (LT), relative lens thickness (RLT), lens position (LP), and relative lens position (RLP), and their determinants among the other ocular biometrics in patients with cataract.

Design: A retrospective and cross-sectional study was performed.

Setting: This study was conducted in a tertiary care ophthalmology department in Shenzhen, China, between 2022 and 2024.

Participants: A total of 715 cataract patients with bilateral ocular biometric measurements using Lenstar LS-900 were recruited.

Outcome measures: The lens-specific biometrics of the bilateral eyes were analyzed separately, with results of the left eyes to validate those of the right eyes. The eyes were divided into two sex groups, three axial length (AL) groups, and four age groups. Independent t-test and Mann-Whitney U test were performed to analyze the differences in sex groups. One-way analysis of variance and Kruskal-Wallis test were used to compare different age and axial length groups. Spearman's correlation tests were conducted to assess the correlations between each lens-specific biometric and the other ocular biometrics, including central corneal thickness (CCT), corneal curvature (CR), anterior chamber depth (ACD), AL, white-to-white corneal diameter (WTW), anterior corneal astigmatism (ACA), pupil size (PS), angle kappa, and iris center distance (ICD). Univariable and multivariable linear regression analyses were used to determine those independent determinants for lens-specific biometrics.

Results: LT was significantly thicker in females, older patients, and eyes of shorter AL (all P < 0.05, except in the sex group of the left eyes), while RLT was increased in eyes of short AL and older patients in bilateral eyes. LP showed anterior displacement in females, older patients, and eyes of shorter AL in both right and left eyes, while RLP only showed significant differences in different AL groups (P < 0.0001). ACD was correlated to all lens-specific biometrics in bilateral eyes (r = -0.77 to 0.87), while correlations of other ocular biometrics to lens-specific biometrics varied between right and left eyes. ACD was identified as the dominant determinant for all lens-specific biometrics in bilateral eyes (β = -0.70 to 0.66). AL was found to inversely predict the RLT and RLP changes in both eyes (all β = -0.01).

Conclusions: Distributions of lens-specific biometrics varied with sex, age, and AL, and the lens-specific biometrics were correlated to similar but also distinct determinants in bilateral eyes. Our study provides a better understanding of the significance of lensspecific biometrics in preoperative assessments and personalization of cataract surgery in patients with diverse anatomical and demographic characteristics.

白内障患者晶状体生物特征的分布和决定因素:来自生物特征的见解和对手术精度的影响。
目的:探讨白内障患者晶状体特异性生物特征,包括晶状体厚度(LT)、相对晶状体厚度(RLT)、晶状体位置(LP)和相对晶状体位置(RLP)的分布规律及其在其他眼部生物特征中的决定因素。设计:进行回顾性和横断面研究。背景:本研究于2022年至2024年在中国深圳的一家三级保健眼科进行。参与者:共招募715例白内障患者,使用Lenstar LS-900进行双侧眼生物特征测量。结果测量:分别分析双眼晶状体特异性生物特征,以左眼的结果验证右眼的结果。眼睛分为两个性别组、三个轴长组和四个年龄组。采用独立t检验和Mann-Whitney U检验分析性别组间差异。采用单因素方差分析和Kruskal-Wallis检验对不同年龄和轴长组进行比较。进行Spearman相关检验,以评估每种晶状体特异性生物特征与其他眼部生物特征之间的相关性,包括角膜中央厚度(CCT)、角膜曲率(CR)、前房深度(ACD)、AL、白-白角膜直径(WTW)、角膜前散光(ACA)、瞳孔大小(PS)、角kappa和虹膜中心距离(ICD)。单变量和多变量线性回归分析用于确定晶状体特异性生物特征的独立决定因素。结果:女性、老年患者及短AL组的RLT均显著增厚(除左眼性别组外,均P < 0.05),而短AL组及老年患者双侧眼RLT均增加。LP在女性、老年、短AL组中均表现为右眼和左眼前移位,而RLP仅在不同AL组中有显著差异(P < 0.0001)。ACD与双眼所有晶状体特异性生物特征相关(r = -0.77 ~ 0.87),而其他眼部生物特征与晶状体特异性生物特征的相关性在左右眼之间存在差异。ACD被确定为双眼所有晶状体特异性生物特征的主要决定因素(β = -0.70至0.66)。AL与双眼RLT和RLP变化呈负相关(均β = -0.01)。结论:晶状体特异性生物特征的分布随性别、年龄和AL而变化,并且晶状体特异性生物特征与双侧眼睛相似但也不同的决定因素相关。我们的研究有助于更好地理解晶状体特异性生物识别技术在具有不同解剖和人口统计学特征的患者白内障手术术前评估和个性化中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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