Nature aging最新文献_第6页

Replacement as an aging intervention. 替代作为一种老龄化干预。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-05-08 DOI: 10.1038/s43587-025-00858-6

Sierra Lore, Jesse R Poganik, Anthony Atala, George Church, Vadim N Gladyshev, Morten Scheibye-Knudsen, Eric Verdin

{"title":"Replacement as an aging intervention.","authors":"Sierra Lore, Jesse R Poganik, Anthony Atala, George Church, Vadim N Gladyshev, Morten Scheibye-Knudsen, Eric Verdin","doi":"10.1038/s43587-025-00858-6","DOIUrl":"10.1038/s43587-025-00858-6","url":null,"abstract":"Substantial progress in aging research continues to deepen our understanding of the fundamental mechanisms of aging, yet there is a lack of interventions conclusively shown to attenuate the processes of aging in humans. By contrast, replacement interventions such as joint replacements, pacemaker devices and transplant therapies have a long history of restoring function in injury or disease contexts. Here, we consider biological and synthetic replacement-based strategies as aging interventions. We discuss innovations in tissue engineering, such as the use of scaffolds or bioprinting to generate functional tissues, methods for enhancing donor-recipient compatibility through genetic engineering and recent progress in both cell therapies and xenotransplantation strategies. We explore synthetic approaches including prostheses, external devices and brain-machine interfaces. Additionally, we evaluate the evidence from heterochronic parabiosis experiments in mice and donor-recipient age-mismatched transplants to consider whether systemic benefits could result from personalized replacement approaches. Finally, we outline key challenges and future directions required to advance replacement therapies as viable, scalable and ethical interventions for aging.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"750-764"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell therapies for Parkinson's disease. 帕金森病的干细胞疗法。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00885-3

Yahyah Aman

引用次数: 0

mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice. mRNA代谢调节因子人抗原R （HuR）调节老年小鼠年龄相关性听力损失。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-05-20 DOI: 10.1038/s43587-025-00860-y

Siwei Guo, Jieying Cao, Guodong Hong, Yuning Song, Ming Xia, Peipei Li, Wei Yuan, Yu Xiao, Guoqiang Sun, Shuang Liu, Shengda Cao, Jieyu Qi, Xiuli Bi, Ziyi Liu, Yunhao Wu, Wen Li, Xiaoxu Zhao, Jiangang Gao, Renjie Chai, Xiaolong Fu

{"title":"mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice.","authors":"Siwei Guo, Jieying Cao, Guodong Hong, Yuning Song, Ming Xia, Peipei Li, Wei Yuan, Yu Xiao, Guoqiang Sun, Shuang Liu, Shengda Cao, Jieyu Qi, Xiuli Bi, Ziyi Liu, Yunhao Wu, Wen Li, Xiaoxu Zhao, Jiangang Gao, Renjie Chai, Xiaolong Fu","doi":"10.1038/s43587-025-00860-y","DOIUrl":"10.1038/s43587-025-00860-y","url":null,"abstract":"Age-related hearing loss (ARHL) is among the most prevalent and complex disorders in older adults. However, the pathogenesis of ARHL remains poorly understood. Using a single-cell transcriptomic landscape of mouse cochlea at five time points (1, 2, 5, 12 and 15 months), we found that the levels of human antigen R (HuR)-a classical RNA-binding protein-increase with age. Here we show that HuR is specifically transported from the nucleus to the cytoplasm in hair cells in both aging mice and nonhuman primates. HuR overexpression in cochlea could successfully alleviate ARHL in aged mice. Meanwhile, HuR deficiency led to premature hearing dysfunction characterized by degeneration of stereocilia and the subsequent loss of hair cells. RNA immunoprecipitation sequencing analysis revealed that HuR can bind to messenger RNAs that enable stereocilia maintenance, including Gnai3. Adeno-associated virus-mediated Gnai3 overexpression partially rescues the hearing defects in HuR-deficient mice. Taken together, these findings indicate that HuR is a potential therapeutic target for ARHL.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 5","pages":"848-867"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM_2.5) exposure on dementia. 长期暴露于环境细颗粒物（PM2.5）对痴呆健康影响的系统回顾和举证责任荟萃分析。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1038/s43587-025-00844-y

Xinmei Huang, Jaimie Steinmetz, Elizabeth K Marsh, Aleksandr Y Aravkin, Charlie Ashbaugh, Christopher J L Murray, Fanghan Yang, John S Ji, Peng Zheng, Reed J D Sorensen, Sarah Wozniak, Simon I Hay, Susan A McLaughlin, Vanessa Garcia, Michael Brauer, Katrin Burkart

{"title":"A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM2.5) exposure on dementia.","authors":"Xinmei Huang, Jaimie Steinmetz, Elizabeth K Marsh, Aleksandr Y Aravkin, Charlie Ashbaugh, Christopher J L Murray, Fanghan Yang, John S Ji, Peng Zheng, Reed J D Sorensen, Sarah Wozniak, Simon I Hay, Susan A McLaughlin, Vanessa Garcia, Michael Brauer, Katrin Burkart","doi":"10.1038/s43587-025-00844-y","DOIUrl":"10.1038/s43587-025-00844-y","url":null,"abstract":"Previous studies have indicated increased dementia risk associated with fine particulate matter (PM2.5) exposure; however, the findings are inconsistent. In this systematic review, we assessed the association between long-term PM2.5 exposure and dementia outcomes using the Burden of Proof meta-analytic framework, which relaxes log-linear assumptions to better characterize relative risk functions and quantify unexplained between-study heterogeneity (PROSPERO, ID CRD42023421869). Here we report a meta-analysis of 28 longitudinal cohort studies published up to June 2023 that investigated long-term PM2.5 exposure and dementia outcomes. We derived risk-outcome scores (ROSs), highly conservative measures of effect size and evidence strength, mapped onto a 1-5-star rating from 'weak and/or inconsistent evidence' to 'very strong and/or consistent evidence'. We identified a significant nonlinear relationship between PM2.5 exposure and dementia, with a minimum 14% increased risk averaged across PM2.5 levels between 4.5 and 26.9 µg m-3 (the 15th to 85th percentile exposure range across included studies), relative to a reference of 2.0 µg m-3 (n = 49, ROS = 0.13, two stars). We found a significant association of PM2.5 with Alzheimer's disease (n = 12, ROS = 0.32, three stars) but not with vascular dementia. Our findings highlight the potential impact of air pollution on brain aging.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"897-908"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting health and survival through lowered body temperature. 通过降低体温促进健康和生存。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1038/s43587-025-00850-0

Bruno Conti, Rafael de Cabo

{"title":"Promoting health and survival through lowered body temperature.","authors":"Bruno Conti, Rafael de Cabo","doi":"10.1038/s43587-025-00850-0","DOIUrl":"10.1038/s43587-025-00850-0","url":null,"abstract":"Core body temperature (Tb) is a long-established determinant of longevity across species. In this Perspective, we first summarize evidence demonstrating that reducing Tb increases lifespan and that lowered Tb contributes to the antiaging effects of calorie restriction. Next, we discuss recent data that diverge from prior hypotheses on the mechanisms by which Tb affects longevity, suggesting these are limited neither to the thermodynamics of nonenzymatic chemical reactions, nor reduced formation of mitochondrial reactive oxygen species nor lowered metabolic rate. Instead, recent findings in invertebrates show that cold promotes longevity via specific pathways including nutrient sensing and proteostasis, as well as modulating the thermodynamics of proteins and nucleic acids by changing their structure and function, for example, affecting temperature-sensitive ion channels, long-lived temperature-sensitive dauer mutations, base-pair stability and stem-loop RNA structures. Temperature affects the epigenetic signature and inflammation, and lowering Tb can also induce RNA-binding cold shock proteins, activate cold-sensitive kinases and differential splicing to potentially reshape the cellular environment. Finally, we reflect on important future work and the translational potential of temperature management and temperature mimetics.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"740-749"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New biomarkers for early-stage tau pathology in Alzheimer's disease. 阿尔茨海默病早期tau病理的新生物标志物。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00854-w

Rongcan Luo, Jin-Tai Yu

引用次数: 0

Ancient viruses sustain mammalian reproduction. 古老的病毒维持着哺乳动物的繁殖。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00867-5

Caroline A Doherty, Diana J Laird

引用次数: 0

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging. KLRG1识别随年龄增长而积累线粒体改变的调节性T细胞。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.1038/s43587-025-00855-9

Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M Gómez de Las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M Fernández-Díaz, María Beatriz Álvarez-Flores, Ana Ramírez de Molina, Sascha Jung, Antonio Del Sol, Virginia Zorita, Fátima Sánchez-Cabo, Carlos Torroja, María Mittelbrunn

{"title":"KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging.","authors":"Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M Gómez de Las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M Fernández-Díaz, María Beatriz Álvarez-Flores, Ana Ramírez de Molina, Sascha Jung, Antonio Del Sol, Virginia Zorita, Fátima Sánchez-Cabo, Carlos Torroja, María Mittelbrunn","doi":"10.1038/s43587-025-00855-9","DOIUrl":"10.1038/s43587-025-00855-9","url":null,"abstract":"Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification of age-associated T cell subsets in systematic larger analysis in mice. We use this panel to evaluate at the single-cell level mitochondrial and senescence marks in the different age-associated CD4+ T cell subpopulations. Our analysis identifies a subpopulation of regulatory T (Treg) cells that is characterized by the extracellular expression of the co-inhibitory molecule killer cell lectin-like receptor subfamily G member 1 (KLRG1) and accumulates with aging in humans and mice. KLRG1-expressing Treg cells display senescence features such as mitochondrial alterations, increased expression of cell-cycle regulators and genomic DNA damage. Functionally, KLRG1+ Treg cells show a reduced suppressive activity in vivo accompanied by a pro-inflammatory phenotype.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"799-815"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. 症状前帕金森病血液检测定量重复序列基序在转移RNA片段。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1038/s43587-025-00851-z

Nimrod Madrer, Shani Vaknine-Treidel, Tamara Zorbaz, Yonat Tzur, Estelle R Bennett, Paz Drori, Nitzan Suissa, David S Greenberg, Eitan Lerner, Eyal Soreq, Iddo Paldor, Hermona Soreq

{"title":"Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments.","authors":"Nimrod Madrer, Shani Vaknine-Treidel, Tamara Zorbaz, Yonat Tzur, Estelle R Bennett, Paz Drori, Nitzan Suissa, David S Greenberg, Eitan Lerner, Eyal Soreq, Iddo Paldor, Hermona Soreq","doi":"10.1038/s43587-025-00851-z","DOIUrl":"10.1038/s43587-025-00851-z","url":null,"abstract":"Early, efficient Parkinson's disease (PD) tests may facilitate pre-symptomatic diagnosis and disease-modifying therapies. Here we report elevated levels of PD-specific transfer RNA fragments carrying a conserved sequence motif (RGTTCRA-tRFs) in the substantia nigra, cerebrospinal fluid and blood of patients with PD. A whole blood qPCR test detecting elevated RGTTCRA-tRFs and reduced mitochondrial-originated tRFs (MT-tRFs) segregated pre-symptomatic patients with PD from controls (area under the receiver operating characteristic curve (ROC-AUC) of 0.75 versus 0.71 based on traditional clinical scoring). Strengthening PD relevance, patients carrying PD-related mutations presented higher blood RGTTCRA-tRFs/MT-tRFs ratios than mutation-carrying non-symptomatic controls, and RGTTCRA-tRF levels decreased in patients' blood after deep brain stimulation. Furthermore, RGTTCRA-tRFs complementarity to ribosomal RNA and the translation-supporting LeuCAG3-tRF might aggravate PD via translational inhibition, as reflected by disrupted ribosomal association of RGTTCRA-tRFs in depolarized neuroblastoma cells. Our findings show tRF involvement in PD and suggest a potential simple and safe blood test that may aid clinicians in pre-symptomatic PD diagnosis after validation in larger independent cohorts.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"868-882"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recycling tRNA fragment 'trash' into treasure. 将tRNA片段“垃圾”转化为财富。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00870-w

Frank A Middleton

引用次数: 0