{"title":"肌氨酸在预防肌肉减少症方面显示出希望。","authors":"","doi":"10.1038/s43587-025-00954-7","DOIUrl":null,"url":null,"abstract":"Metabolomics and lipidomics uncover the metabolic features and heterogeneity associated with sarcopenia — the age-related loss of muscle mass and strength. Circulating sarcosine levels decrease in sarcopenia and supplementation with sarcosine enhances fat metabolism and muscle repair in mice by activating anti-inflammatory macrophages. These results suggest sarcosine could be used therapeutically to slow sarcopenic progression.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 9","pages":"1663-1664"},"PeriodicalIF":19.4000,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sarcosine shows promise in preventing sarcopenia\",\"authors\":\"\",\"doi\":\"10.1038/s43587-025-00954-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Metabolomics and lipidomics uncover the metabolic features and heterogeneity associated with sarcopenia — the age-related loss of muscle mass and strength. Circulating sarcosine levels decrease in sarcopenia and supplementation with sarcosine enhances fat metabolism and muscle repair in mice by activating anti-inflammatory macrophages. These results suggest sarcosine could be used therapeutically to slow sarcopenic progression.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 9\",\"pages\":\"1663-1664\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00954-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00954-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Metabolomics and lipidomics uncover the metabolic features and heterogeneity associated with sarcopenia — the age-related loss of muscle mass and strength. Circulating sarcosine levels decrease in sarcopenia and supplementation with sarcosine enhances fat metabolism and muscle repair in mice by activating anti-inflammatory macrophages. These results suggest sarcosine could be used therapeutically to slow sarcopenic progression.
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