Nature aging最新文献

Cohort trends in intrinsic capacity in England and China.

IF 17

Nature aging Pub Date : 2024-12-19 DOI: 10.1038/s43587-024-00741-w

John R Beard, Katja Hanewald, Yafei Si, Jotheeswaran Amuthavalli Thiyagarajan, Dario Moreno-Agostino

引用次数: 0

Supporting the sexual healthcare needs of aging women

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00725-w

Holly N. Thomas

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Emerging therapeutic strategies to mitigate female and male reproductive aging

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00771-4

Yasmyn E. Winstanley, Jennifer S. Stables, Macarena B. Gonzalez, Takashi Umehara, Robert J. Norman, Rebecca L. Robker

{"title":"Emerging therapeutic strategies to mitigate female and male reproductive aging","authors":"Yasmyn E. Winstanley, Jennifer S. Stables, Macarena B. Gonzalez, Takashi Umehara, Robert J. Norman, Rebecca L. Robker","doi":"10.1038/s43587-024-00771-4","DOIUrl":"10.1038/s43587-024-00771-4","url":null,"abstract":"People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development. Preclinical studies, in mouse models of aging, have identified pharmaceutical candidates that improve egg and sperm quality. Further, a diverse array of medically assisted reproduction methodologies, including those that stimulate rare ovarian follicles and rejuvenate egg quality using mitochondria, may have future utility for older patients. Finally, we highlight the many knowledge gaps and possible future directions in the field of therapeutics to extend the age of healthy human reproduction. People now choose to start families in their 30s to 40s, when fertility is low owing to reproductive aging. In this Perspective, the authors highlight the absence of clinically confirmed therapeutics to mitigate reproductive aging or extend fertility, and they summarize the range of emerging strategies and point to knowledge gaps and future directions in the field.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1682-1696"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy longevity requires bridging reproductive medicine, aging research and public engagement 健康长寿需要在生殖医学、老龄化研究和公众参与之间架起桥梁

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00713-0

Zhongwei Huang, on behalf of NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE)

引用次数: 0

Reproductive aging research as a gateway to health and wellbeing

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00786-x

引用次数: 0

Healthy aging in individuals born after assisted reproductive technology is a research area for the future

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00721-0

Anna Sophie Lebech Kjaer, Maria Linander Vestager, Rikke Beck Jensen, Anja Pinborg

引用次数: 0

Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00733-w

Stefania Benonisdottir, Vincent J. Straub, Augustine Kong, Melinda C. Mills

{"title":"Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring","authors":"Stefania Benonisdottir, Vincent J. Straub, Augustine Kong, Melinda C. Mills","doi":"10.1038/s43587-024-00733-w","DOIUrl":"10.1038/s43587-024-00733-w","url":null,"abstract":"Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increasingly important. Although monogenic genetic effects are known, the genetics underlying human reproductive traits are complex, with both causal effects and statistical bias often confounded by socioeconomic factors. Here, we review genome-wide association studies (GWASs) of 44 reproductive traits of both female and male individuals from 2007 to early 2024, examining reproductive behavior, reproductive lifespan and aging, infertility and hormonal concentration. Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproductive traits, more than half of which are linked to rare Mendelian disorders, including ten genes linked to reproductive-related disorders: FSHB, MCM8, DNAH2, WNT4, ESR1, IGSF1, THRB, BRWD1, CYP19A1 and PTPRF. We also review the relationship of reproductive genetics to related health and behavioral traits, aging and longevity and the effect of parental age on offspring outcomes as well as reflecting on limitations, open questions and challenges in this fast-moving field. Benonisdottir et al. review the genetics of reproductive traits and examine how these associate with links to health, behavior, aging and longevity as well as outcomes for offspring.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1745-1759"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The CALERIE Genomic Data Resource. CALERIE 基因组数据资源。

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00775-0

C P Ryan, D L Corcoran, N Banskota, C Eckstein Indik, A Floratos, R Friedman, M S Kobor, V B Kraus, W E Kraus, J L MacIsaac, M C Orenduff, C F Pieper, J P White, L Ferrucci, S Horvath, K M Huffman, D W Belsky

{"title":"The CALERIE Genomic Data Resource.","authors":"C P Ryan, D L Corcoran, N Banskota, C Eckstein Indik, A Floratos, R Friedman, M S Kobor, V B Kraus, W E Kraus, J L MacIsaac, M C Orenduff, C F Pieper, J P White, L Ferrucci, S Horvath, K M Huffman, D W Belsky","doi":"10.1038/s43587-024-00775-0","DOIUrl":"10.1038/s43587-024-00775-0","url":null,"abstract":"<p><p>Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 .</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallmarks of female reproductive aging in physiologic aging mice 生理衰老小鼠雌性生殖衰老的特征

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00769-y

Julia L. Balough, Shweta S. Dipali, Karen Velez, T. Rajendra Kumar, Francesca E. Duncan

{"title":"Hallmarks of female reproductive aging in physiologic aging mice","authors":"Julia L. Balough, Shweta S. Dipali, Karen Velez, T. Rajendra Kumar, Francesca E. Duncan","doi":"10.1038/s43587-024-00769-y","DOIUrl":"10.1038/s43587-024-00769-y","url":null,"abstract":"The female reproductive axis is one of the first organ systems to age, which has consequences for fertility and overall health. Here, we provide a comprehensive overview of the biological process of female reproductive aging across reproductive organs, tissues and cells based on research with widely used physiologic aging mouse models, and describe the mechanisms that underpin these phenotypes. Overall, aging is associated with dysregulation of the hypothalamic–pituitary–ovarian axis, perturbations of the ovarian stroma, reduced egg quantity and quality, and altered uterine morphology and function that contributes to reduced capacity for fertilization and impaired embryo development. Ultimately, these age-related phenotypes contribute to altered pregnancy outcomes and adverse consequences in offspring. Conserved mechanisms of aging, as well as those unique to the reproductive system, underlie these phenotypes. The knowledge of such mechanisms will lead to development of therapeutics to extend female reproductive longevity and support endocrine function and overall health. Female reproductive system aging has consequences for fertility and overall health. In this Review, the authors provide a comprehensive overview of the biological process of female reproductive aging based on research with physiologic aging mouse models, and describe the mechanisms that underlie these phenotypes.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1711-1730"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00767-0

Celine Camon, Michael Garratt, Stephanie M. Correa

{"title":"Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause","authors":"Celine Camon, Michael Garratt, Stephanie M. Correa","doi":"10.1038/s43587-024-00767-0","DOIUrl":"10.1038/s43587-024-00767-0","url":null,"abstract":"Sex hormone signaling declines during aging, from early midlife through menopause, as a consequence of reduced circulating estrogens and decreased receptiveness to these hormones in target tissues. Estrogens preserve energy homeostasis and promote metabolic health via coordinated and simultaneous effects throughout the brain and body. Age-associated loss of estrogen production during menopause has been implicated in a higher risk for metabolic diseases and increased mortality. However, it remains unclear whether age-associated changes in homeostasis are dependent on reduced estrogen signaling during menopause. Although menopausal hormone therapies containing estrogens can alleviate symptoms, concerns about the risks involved have contributed to a broad decline in the use of these approaches. Non-hormonal therapies have emerged that target tissues or pathways with varying levels of selectivity, reducing risk. We summarize here the broad effects of estrogen loss on homeostasis during menopause, current and emerging therapies and opportunities for understanding homeostatic disruptions associated with menopause. Sex hormone signaling declines during aging. In this Review, the authors provide an overview of the role of estrogen signaling in the maintenance of energy homeostasis and the dysregulation of this equilibrium during menopause, dissect the contributions of hormonal decline and aging to health changes and discuss current and emerging therapies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1731-1744"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0