Nature aging最新文献

Phenome-wide associations of human aging uncover sex-specific dynamics. 人类衰老的全貌关联揭示了性别特异性动态变化。

IF 17

Nature aging Pub Date : 2024-11-05 DOI: 10.1038/s43587-024-00734-9

Lee Reicher, Noam Bar, Anastasia Godneva, Yotam Reisner, Liron Zahavi, Nir Shahaf, Raja Dhir, Adina Weinberger, Eran Segal

{"title":"Phenome-wide associations of human aging uncover sex-specific dynamics.","authors":"Lee Reicher, Noam Bar, Anastasia Godneva, Yotam Reisner, Liron Zahavi, Nir Shahaf, Raja Dhir, Adina Weinberger, Eran Segal","doi":"10.1038/s43587-024-00734-9","DOIUrl":"https://doi.org/10.1038/s43587-024-00734-9","url":null,"abstract":"Aging varies significantly among individuals of the same chronological age, indicating that biological age (BA), estimated from molecular and physiological biomarkers, may better reflect aging. Prior research has often ignored sex-specific differences in aging patterns and mainly focused on aging biomarkers from a single data modality. Here we analyze a deeply phenotyped longitudinal cohort (10K project, Israel) of 10,000 healthy individuals aged 40-70 years that includes clinical, physiological, behavioral, environmental and multiomic parameters. Follow-up visits are scheduled every 2 years for a total of 25 years. We devised machine learning models of chronological age and computed biological aging scores that represented diverse physiological systems, revealing different aging patterns among sexes. Higher BA scores were associated with a higher prevalence of age-related medical conditions, highlighting the clinical relevance of these scores. Our analysis revealed system-specific aging dynamics and the potential of deeply phenotyped cohorts to accelerate improvements in our understanding of chronic diseases. Our findings present a more holistic view of the aging process, and lay the foundation for personalized medical prevention strategies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from the HEALEY adaptive platform trial in amyotrophic lateral sclerosis. 肌萎缩性脊髓侧索硬化症 HEALEY 适应性平台试验的启示。

IF 17

Nature aging Pub Date : 2024-11-01 DOI: 10.1038/s43587-024-00740-x

Sabrina Paganoni, Brittney Harkey, Elisa Giacomelli, Merit Cudkowicz

引用次数: 0

Rejuvenating older neural stem cells. 让年老的神经干细胞重新焕发青春。

IF 17

Nature aging Pub Date : 2024-10-31 DOI: 10.1038/s43587-024-00761-6

George Andrew S Inglis

引用次数: 0

Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype. 撤回声明：KDM4 可协调衰老细胞的表观基因组重塑，并增强衰老相关的分泌表型。

IF 17

Nature aging Pub Date : 2024-10-31 DOI: 10.1038/s43587-024-00749-2

Boyi Zhang, Qilai Long, Shanshan Wu, Qixia Xu, Shuling Song, Liu Han, Min Qian, Xiaohui Ren, Hanxin Liu, Jing Jiang, Jianming Guo, Xiaoling Zhang, Xing Chang, Qiang Fu, Eric W-F Lam, Judith Campisi, James L Kirkland, Yu Sun

引用次数: 0

The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke. 泡沫细胞衍生的外泌体 miRNA Novel-3 在缺血性中风期间驱动神经炎症和铁变态反应。

IF 17

Nature aging Pub Date : 2024-10-28 DOI: 10.1038/s43587-024-00727-8

Chuan Qin, Ming-Hao Dong, Yue Tang, Yun-Hui Chu, Luo-Qi Zhou, Hang Zhang, Sheng Yang, Lu-Yang Zhang, Xiao-Wei Pang, Li-Fang Zhu, Wei Wang, Dai-Shi Tian

{"title":"The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke.","authors":"Chuan Qin, Ming-Hao Dong, Yue Tang, Yun-Hui Chu, Luo-Qi Zhou, Hang Zhang, Sheng Yang, Lu-Yang Zhang, Xiao-Wei Pang, Li-Fang Zhu, Wei Wang, Dai-Shi Tian","doi":"10.1038/s43587-024-00727-8","DOIUrl":"https://doi.org/10.1038/s43587-024-00727-8","url":null,"abstract":"Large artery atherosclerosis (LAA) is a prevalent cause of acute ischemic stroke (AIS). Understanding the mechanisms linking atherosclerosis to stroke is essential for developing appropriate intervention strategies. Here, we found that the exosomal miRNA Novel-3 is selectively upregulated in the plasma of patients with LAA-AIS. Notably, Novel-3 was predominantly expressed in macrophage-derived foam cells, and its expression correlated with atherosclerotic plaque vulnerability in patients undergoing carotid endarterectomy. Exploring the function of Novel-3 in a mouse model of cerebral ischemia, we found that Novel-3 exacerbated ischemic injury and targeted microglia and macrophages expressing ionized calcium-binding adapter molecule 1 in peri-infarct regions. Mechanistically, Novel-3 increased ferroptosis and neuroinflammation by interacting with striatin (STRN) and downregulating the phosphoinositide 3-kinase-AKT-mechanistic target of rapamycin signaling pathway. Blocking Novel-3 activity or overexpressing STRN provided neuroprotection under ischemic conditions. Our findings suggest that exosomal Novel-3, which is primarily derived from macrophage-derived foam cells, targets microglia and macrophages in the brain to induce neuroinflammation and could serve as a potential therapeutic target for patients with stroke who have atherosclerosis.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer's disease. 信息提供者的特征会影响基于临床痴呆分级的阿尔茨海默病分期。

IF 17

Nature aging Pub Date : 2024-10-25 DOI: 10.1038/s43587-024-00732-x

Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia

引用次数: 0

The Clinical Dementia Rating scale is useful but caution is needed. 临床痴呆评定量表很有用，但需要谨慎。

IF 17

Nature aging Pub Date : 2024-10-25 DOI: 10.1038/s43587-024-00742-9

Ronald C Petersen

引用次数: 0

METTL3 governs thymocyte development and thymic involution by regulating ferroptosis. METTL3 通过调节铁蛋白沉积来控制胸腺细胞的发育和胸腺的消退。

IF 17

Nature aging Pub Date : 2024-10-23 DOI: 10.1038/s43587-024-00724-x

Huiru Jing, Jiayu Song, Jie Sun, Shaojun Su, Jin Hu, Haojian Zhang, Yanmin Bi, Bing Wu

{"title":"METTL3 governs thymocyte development and thymic involution by regulating ferroptosis.","authors":"Huiru Jing, Jiayu Song, Jie Sun, Shaojun Su, Jin Hu, Haojian Zhang, Yanmin Bi, Bing Wu","doi":"10.1038/s43587-024-00724-x","DOIUrl":"https://doi.org/10.1038/s43587-024-00724-x","url":null,"abstract":"Given its central role in immune aging, it is important to identify the regulators of thymic involution. While conventional programmed cell death has a fundamental role in thymocyte development, how cell death pathways contribute to thymic involution are unclear. In this study, we found that CD4+CD8+ double-positive (DP) thymocytes acquired the characteristics of senescence in aged mice undergoing thymic involution, while expression of the m6A methyltransferase-like protein 3 (METTL3), which is enriched in DP cells from young mice, decreased with aging. By conditionally deleting METTL3 in T cells, we revealed a critical role for METTL3 in DP cell survival and in restraining the features of aging in DP thymocytes by preventing ferroptosis signaling through glutathione peroxidase 4. Mechanistically, glutathione peroxidase 4 was maintained by METTL3 at the translational level, independently of its methyltransferase activity. Furthermore, we found that pharmacological inhibition of ferroptosis promoted DP cell survival and attenuated the features of aging in DP thymocytes. These findings uncover a role for METTL3-regulated ferroptosis in thymic involution and identify strategies to restore thymic function.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metformin slows signs of primate aging. 二甲双胍可减缓灵长类动物的衰老迹象。

IF 17

Nature aging Pub Date : 2024-10-22 DOI: 10.1038/s43587-024-00748-3

Anna Kriebs

引用次数: 0

A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age. 根据小鼠纵向衰老研究得出的血液学时钟来估算生物年龄。

IF 17

Nature aging Pub Date : 2024-10-18 DOI: 10.1038/s43587-024-00728-7

Jorge Martinez-Romero, Maria Emilia Fernandez, Michel Bernier, Nathan L Price, William Mueller, Julián Candia, Simonetta Camandola, Osorio Meirelles, Yi-Han Hu, Zhiguang Li, Nigus Asefa, Andrew Deighan, Camila Vieira Ligo Teixeira, Dushani L Palliyaguru, Carlos Serrano, Nicolas Escobar-Velasquez, Stephanie Dickinson, Eric J Shiroma, Luigi Ferrucci, Gary A Churchill, David B Allison, Lenore J Launer, Rafael de Cabo

{"title":"A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age.","authors":"Jorge Martinez-Romero, Maria Emilia Fernandez, Michel Bernier, Nathan L Price, William Mueller, Julián Candia, Simonetta Camandola, Osorio Meirelles, Yi-Han Hu, Zhiguang Li, Nigus Asefa, Andrew Deighan, Camila Vieira Ligo Teixeira, Dushani L Palliyaguru, Carlos Serrano, Nicolas Escobar-Velasquez, Stephanie Dickinson, Eric J Shiroma, Luigi Ferrucci, Gary A Churchill, David B Allison, Lenore J Launer, Rafael de Cabo","doi":"10.1038/s43587-024-00728-7","DOIUrl":"https://doi.org/10.1038/s43587-024-00728-7","url":null,"abstract":"Biological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging clock to predict blood age and determine whether the difference between predicted age and chronologic age (aging gap) is associated with advanced aging in mice. Data from 2,562 mice of both sexes and three strains were drawn from two longitudinal studies of aging. Eight hematological variables and two metabolic indices were collected longitudinally (12,010 observations). Blood age was predicted using a deep neural network. Blood age was significantly correlated with chronological age, and aging gap was positively associated with mortality risk and frailty. Platelets were identified as the strongest age predictor by the deep neural network. An aging clock based on routinely collected blood measures has the potential to provide a practical clinical tool to better understand individual variability in the aging process.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0