Nature aging最新文献_第2页

LGBTQ older adults deserve safe and affirming housing. 男女同性恋、双性恋、变性者和跨性别者中的老年人理应获得安全、平等的住房。

IF 17

Nature aging Pub Date : 2024-10-15 DOI: 10.1038/s43587-024-00739-4

Philippe Saad

引用次数: 0

SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease SEA-AD 是阿尔茨海默病的多模态细胞图谱和资源

IF 17

Nature aging Pub Date : 2024-10-14 DOI: 10.1038/s43587-024-00719-8

Michael Hawrylycz, Eitan S. Kaplan, Kyle J. Travaglini, Mariano I. Gabitto, Jeremy A. Miller, Lydia Ng, Jennie L. Close, Rebecca D. Hodge, Brian Long, Tyler Mollenkopf, Shoaib Mufti, Nicole M. Gatto, Eric B. Larson, Paul K. Crane, Thomas J. Grabowski, C. Dirk Keene, Ed S. Lein

引用次数: 0

Francisco Lopera (1951-2024). 弗朗西斯科-洛佩拉（1951-2024）。

IF 17

Nature aging Pub Date : 2024-10-09 DOI: 10.1038/s43587-024-00735-8

Agustín Ibáñez, Randall Bateman, Hernando Santamaria-García

引用次数: 0

The brain–body energy conservation model of aging 脑-体能量守恒衰老模型。

IF 17

Nature aging Pub Date : 2024-10-08 DOI: 10.1038/s43587-024-00716-x

Evan D. Shaulson, Alan A. Cohen, Martin Picard

{"title":"The brain–body energy conservation model of aging","authors":"Evan D. Shaulson, Alan A. Cohen, Martin Picard","doi":"10.1038/s43587-024-00716-x","DOIUrl":"10.1038/s43587-024-00716-x","url":null,"abstract":"Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage accumulation increases cellular energy expenditure, yet whole-body energy expenditure remains stable or decreases with age. We resolve this apparent contradiction by positioning the brain as the mediator and broker in the organismal energy economy. As somatic tissues accumulate damage over time, costly intracellular stress responses are activated, causing aging or senescent cells to secrete cytokines that convey increased cellular energy demand (hypermetabolism) to the brain. To conserve energy in the face of a shrinking energy budget, the brain deploys energy conservation responses, which suppress low-priority processes, producing fatigue, physical inactivity, blunted sensory capacities, immune alterations and endocrine ‘deficits’. We term this cascade the brain–body energy conservation (BEC) model of aging. The BEC outlines (1) the energetic cost of cellular aging, (2) how brain perception of senescence-associated hypermetabolism may drive the phenotypic manifestations of aging and (3) energetic principles underlying the modifiability of aging trajectories by stressors and geroscience interventions. The authors offer a new energy-focused perspective on aging by introducing a brain–body model that positions the brain’s response to cytokine signals of hypermetabolism as a mechanistic link between the cellular hallmarks and organismal manifestations of aging.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senescent stromal fibroblasts in bladder tumors support cancer progression. 膀胱肿瘤中的衰老基质成纤维细胞支持癌症进展。

IF 17

Nature aging Pub Date : 2024-10-08 DOI: 10.1038/s43587-024-00738-5

引用次数: 0

Immune aging impairs tumor control 免疫老化损害肿瘤控制

IF 17

Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00737-6

Hannah Walters

引用次数: 0

Implausibility of radical life extension in humans in the twenty-first century. 二十一世纪人类彻底延长寿命的不可能性。

IF 17

Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00702-3

S Jay Olshansky, Bradley J Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez

{"title":"Implausibility of radical life extension in humans in the twenty-first century.","authors":"S Jay Olshansky, Bradley J Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez","doi":"10.1038/s43587-024-00702-3","DOIUrl":"https://doi.org/10.1038/s43587-024-00702-3","url":null,"abstract":"<p><p>Over the course of the twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven by advances in public health and medicine. Mortality reduction was observed initially at an early age and continued into middle and older ages. However, it was unclear whether this phenomenon and the resulting accelerated rise in life expectancy would continue into the twenty-first century. Here using demographic survivorship metrics from national vital statistics in the eight countries with the longest-lived populations (Australia, France, Italy, Japan, South Korea, Spain, Sweden and Switzerland) and in Hong Kong and the United States from 1990 to 2019, we explored recent trends in death rates and life expectancy. We found that, since 1990, improvements overall in life expectancy have decelerated. Our analysis also revealed that resistance to improvements in life expectancy increased while lifespan inequality declined and mortality compression occurred. Our analysis suggests that survival to age 100 years is unlikely to exceed 15% for females and 5% for males, altogether suggesting that, unless the processes of biological aging can be markedly slowed, radical human life extension is implausible in this century.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimistic versus pessimistic scenarios for future life expectancy. 未来预期寿命的乐观与悲观情景。

IF 17

Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00722-z

Dmitri Jdanov, Domantas Jasilionis

引用次数: 0

Digital reminders improve vaccination rates 数字提醒可提高疫苗接种率。

IF 17

Nature aging Pub Date : 2024-10-04 DOI: 10.1038/s43587-024-00736-7

George Andrew S. Inglis

引用次数: 0

Sex dimorphism in the aged melanoma microenvironment 老年黑色素瘤微环境中的性别双态性。

IF 17

Nature aging Pub Date : 2024-10-04 DOI: 10.1038/s43587-024-00729-6

Jean Nakhle

引用次数: 0