Nature aging最新文献_第3页

A TFEB-TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state. tfeb - tgf - β轴系统调节滞育、干细胞恢复力和防止衰老样状态。

IF 17

Nature aging Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI: 10.1038/s43587-025-00911-4

Tim J Nonninger, Jennifer Mak, Birgit Gerisch, Valentina Ramponi, Kazuto Kawamura, Roberto Ripa, Klara Schilling, Christian Latza, Jonathan Kölschbach, Manuel Serrano, Adam Antebi

{"title":"A TFEB-TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state.","authors":"Tim J Nonninger, Jennifer Mak, Birgit Gerisch, Valentina Ramponi, Kazuto Kawamura, Roberto Ripa, Klara Schilling, Christian Latza, Jonathan Kölschbach, Manuel Serrano, Adam Antebi","doi":"10.1038/s43587-025-00911-4","DOIUrl":"10.1038/s43587-025-00911-4","url":null,"abstract":"Diapause is a long-lived state of resilience that allows organisms to outlast adversity. Caenorhabditis elegans can endure months in a fasting-induced adult reproductive diapause (ARD) and, upon refeeding, regenerate and reproduce. Here we find that mutants of ARD master regulator hlh-30/TFEB arrest in a senescence-like state during ARD and refeeding, in which germline stem cells are characterized by DNA damage, nucleolar expansion, cell cycle arrest and mitochondrial dysfunction, alongside dysregulated immune and growth metabolic signatures, elevated senescence-associated β-galactosidase and premature aging at the organismal level. Forward genetic screens reveal a TFEB-TGFβ signaling axis that systemically controls diapause, stem cell longevity and senescence, aligning nutrient supply to proper metabolism and growth signaling. Notably, TFEB's vital role is conserved in mouse embryonic and human cancer diapause. Thus, ARD offers a powerful model to study stem cell longevity and senescence in vivo, directly relevant to mammals.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"1340-1357"},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease. DunedinPACNI从单个大脑图像中估计衰老的纵向速度，以跟踪健康和疾病。

IF 17

Nature aging Pub Date : 2025-07-01 DOI: 10.1038/s43587-025-00897-z

Ethan T Whitman, Maxwell L Elliott, Annchen R Knodt, Wickliffe C Abraham, Tim J Anderson, Nicholas J Cutfield, Sean Hogan, David Ireland, Tracy R Melzer, Sandhya Ramrakha, Karen Sugden, Reremoana Theodore, Benjamin S Williams, Avshalom Caspi, Terrie E Moffitt, Ahmad R Hariri

{"title":"DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease.","authors":"Ethan T Whitman, Maxwell L Elliott, Annchen R Knodt, Wickliffe C Abraham, Tim J Anderson, Nicholas J Cutfield, Sean Hogan, David Ireland, Tracy R Melzer, Sandhya Ramrakha, Karen Sugden, Reremoana Theodore, Benjamin S Williams, Avshalom Caspi, Terrie E Moffitt, Ahmad R Hariri","doi":"10.1038/s43587-025-00897-z","DOIUrl":"10.1038/s43587-025-00897-z","url":null,"abstract":"To understand how aging affects functional decline and increases disease risk, it is necessary to develop measures of how fast a person is aging. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain magnetic resonance imaging, that is, the Dunedin Pace of Aging Calculated from NeuroImaging (DunedinPACNI). Exporting this measure to the Alzheimer's Disease Neuroimaging Initiative, UK Biobank and BrainLat datasets revealed that faster DunedinPACNI predicted cognitive impairment, accelerated brain atrophy and conversion to diagnosed dementia. Faster DunedinPACNI also predicted physical frailty, poor health, future chronic diseases and mortality in older adults. When compared to brain age gap, DunedinPACNI was similarly or more strongly related to clinical outcomes. DunedinPACNI is a next-generation brain magnetic resonance imaging biomarker that can help researchers explore aging effects on health outcomes and evaluate the effectiveness of antiaging strategies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts. 在现实世界初级保健队列中监测临床健康结果的内在能力的参考百分位数。

IF 17

Nature aging Pub Date : 2025-07-01 Epub Date: 2025-05-13 DOI: 10.1038/s43587-025-00861-x

Philipe de Souto Barreto, Wan-Hsuan Lu, Neda Tavassoli, Fatemeh Nourhashémi, Renato Gorga Bandeira de Mello, Eduardo Ferriolli, Sophie Guyonnet, Yves Rolland, Maria Eugenia Soto Martín, Bruno Vellas

{"title":"Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts.","authors":"Philipe de Souto Barreto, Wan-Hsuan Lu, Neda Tavassoli, Fatemeh Nourhashémi, Renato Gorga Bandeira de Mello, Eduardo Ferriolli, Sophie Guyonnet, Yves Rolland, Maria Eugenia Soto Martín, Bruno Vellas","doi":"10.1038/s43587-025-00861-x","DOIUrl":"10.1038/s43587-025-00861-x","url":null,"abstract":"Intrinsic capacity (IC) refers to physical and mental capacities that determine healthy aging. IC is the central element of the World Health Organization care pathway 'Integrated Care for Older People' (ICOPE). However, the operationalization of a composite IC measurement in clinical settings remains to be defined. We used screening data from ICOPE implementation in a real-life population of 27,706 adults 60 years or older that were users of primary care services to elaborate and cross-validate IC scores and centile values for men and women. Here, we show that IC centiles were cross-sectionally associated with comorbidity, frailty and limitations in both activities of daily living and instrumental activities of daily living. External validation using populations from high-income (French INSPIRE-T cohort) and upper-middle-income (ICOPE Brazil) countries validated the associations between IC centiles and clinical outcomes. The IC centiles developed using ICOPE screening data constitute a standardized parameter to monitor individual and population IC through a clinically friendly approach.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"1217-1231"},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin health and biological aging. 皮肤健康与生物老化。

IF 17

Nature aging Pub Date : 2025-07-01 Epub Date: 2025-06-17 DOI: 10.1038/s43587-025-00901-6

David Furman, Johan Auwerx, Anne-Laure Bulteau, George Church, Virginie Couturaud, Laure Crabbe, Kelvin J A Davies, Anabelle Decottignies, Vadim N Gladyshev, Brian K Kennedy, Nicola Neretti, Carine Nizard, Karl Pays, Daisy Robinton, Vittorio Sebastiano, Rachel E B Watson, Meng C Wang, Knut Woltjen

{"title":"Skin health and biological aging.","authors":"David Furman, Johan Auwerx, Anne-Laure Bulteau, George Church, Virginie Couturaud, Laure Crabbe, Kelvin J A Davies, Anabelle Decottignies, Vadim N Gladyshev, Brian K Kennedy, Nicola Neretti, Carine Nizard, Karl Pays, Daisy Robinton, Vittorio Sebastiano, Rachel E B Watson, Meng C Wang, Knut Woltjen","doi":"10.1038/s43587-025-00901-6","DOIUrl":"10.1038/s43587-025-00901-6","url":null,"abstract":"Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on systemic aging. The complex interplay across hallmarks of aging in the skin and systemic biological aging suggests that physiological processes associated with skin aging influence, and are influenced by, systemic hallmarks of aging. This bidirectional relationship provides potential avenues for the prevention of accelerated biological aging and the identification of therapeutic targets. We provide a review of the interactions between skin exposure, aging hallmarks in the skin and associated systemic changes, and their implications in treatment and disease. We also discuss key questions that need to be addressed to maintain skin and overall health, highlighting the need for the development of precise biomarkers and advanced skin models.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"1195-1206"},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOXO3-enhanced mesenchymal progenitor cells impede aging in monkeys. foxo3增强的间充质祖细胞延缓了猴子的衰老。

IF 17

Nature aging Pub Date : 2025-07-01 DOI: 10.1038/s43587-025-00930-1

Anna Kriebs

引用次数: 0

Lifestyle interventions can save over US $500 million in healthcare spending. 生活方式干预可以节省5亿多美元的医疗保健支出。

IF 17

Nature aging Pub Date : 2025-07-01 DOI: 10.1038/s43587-025-00916-z

引用次数: 0

Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice. 提高小胶质细胞中的血管紧张素转换酶（ACE）可预防5xFAD小鼠的阿尔茨海默病。

IF 17

Nature aging Pub Date : 2025-07-01 Epub Date: 2025-06-09 DOI: 10.1038/s43587-025-00879-1

Andrew R Gomez, Hyae Ran Byun, Shaogen Wu, A K M Ghulam Muhammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Kenneth E Bernstein, Richard Ainsworth, Warren G Tourtellotte

{"title":"Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer's disease in 5xFAD mice.","authors":"Andrew R Gomez, Hyae Ran Byun, Shaogen Wu, A K M Ghulam Muhammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Kenneth E Bernstein, Richard Ainsworth, Warren G Tourtellotte","doi":"10.1038/s43587-025-00879-1","DOIUrl":"10.1038/s43587-025-00879-1","url":null,"abstract":"Genome-wide association studies have identified many gene polymorphisms associated with an increased risk of developing late-onset Alzheimer's disease (LOAD). Many of these LOAD risk-associated alleles alter disease pathogenesis by influencing innate immune responses and lipid metabolism of microglia (MG). Here we show that boosting the expression of angiotensin-converting enzyme (ACE), a genome-wide association study LOAD risk-associated gene product, specifically in MG, reduces amyloid-β (Aβ) plaque load, preserves vulnerable neurons and excitatory synapses, and significantly reduces learning and memory abnormalities in the 5xFAD amyloid mouse model of AD. ACE-expressing MG surround plaques more frequently and they have increased Aβ phagocytosis, endolysosomal trafficking and spleen tyrosine kinase activation downstream of the major Aβ receptors, triggering receptor expressed on myeloid cells 2 (Trem2) and C-type lectin domain family 7 member A (Clec7a). These findings establish a role for ACE in enhancing microglial immune function and they identify a potential use for ACE-expressing MG as a cell-based therapy to augment endogenous microglial responses to Aβ in AD.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"1280-1294"},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits. 作者更正：利用头部方向网络中的非规范前庭输入来纠正与年龄相关的导航缺陷。

IF 17

Nature aging Pub Date : 2025-07-01 DOI: 10.1038/s43587-025-00934-x

Xiao-Qian Hu, Kenneth Lap-Kei Wu, Kang-Lin Rong, Ya Ke, Wing-Ho Yung, Daisy Kwok-Yan Shum, Ying-Shing Chan

引用次数: 0

Disease burden, lifetime healthcare cost and long-term intervention impact projections among older adults in Singapore. 新加坡老年人的疾病负担、终生医疗保健费用和长期干预影响预测。

IF 17

Nature aging Pub Date : 2025-07-01 Epub Date: 2025-07-15 DOI: 10.1038/s43587-025-00915-0

Xueying Guo, Bryan Tysinger, Hwee Lin Wee, Mythily Subramaniam, Stefan Ma, Tze Pin Ng, Cynthia Chen

{"title":"Disease burden, lifetime healthcare cost and long-term intervention impact projections among older adults in Singapore.","authors":"Xueying Guo, Bryan Tysinger, Hwee Lin Wee, Mythily Subramaniam, Stefan Ma, Tze Pin Ng, Cynthia Chen","doi":"10.1038/s43587-025-00915-0","DOIUrl":"10.1038/s43587-025-00915-0","url":null,"abstract":"Singapore's rapidly aging population and increasing healthcare demands highlight the need for projections to inform policy planning. Here we adapted a previously published dynamic Markov microsimulation model, the Future Elderly Model, to estimate disease trajectories and healthcare expenditure among adults aged 51 years and older in Singapore. The model simulated four long-term lifestyle interventions aligned with the Healthier SG program from 2020 to 2050. Our projections indicate an increasing prevalence of chronic conditions, comorbidities, obesity and disabilities, with ethnic differences. The projected lifetime healthcare expenditure is the highest among Indians (US $93,900; 95% credible interval (CI), US $68,900-119,000), followed by the Chinese (US $75,700; 95% CI, US $57,600-93,800) and Malays (US $70,000; 95% CI, US $52,000-88,000). Despite having a higher chronic disease burden, Malays are expected to incur lower lifetime expenditure due to their shorter life expectancy. Implementing all 4 interventions could save US $505 million (95% CI, US $462-547 million) in healthcare use by 2050. Sustained lifestyle interventions may moderate the increase in future burdens. Policy strategies should prioritize preventive care tailored to the specific needs of diverse population subgroups.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"1358-1369"},"PeriodicalIF":17.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tau PET positivity marks early clinical transition in Alzheimer's disease progression. Tau PET阳性标志着阿尔茨海默病进展的早期临床转变。

IF 17

Nature aging Pub Date : 2025-07-01 DOI: 10.1038/s43587-025-00932-z

Yahyah Aman

引用次数: 0