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Aged eggs improve within young follicles 老化的卵子在年轻的卵泡内会得到改善。
IF 17
Nature aging Pub Date : 2024-10-01 DOI: 10.1038/s43587-024-00715-y
Jing Wang, Chun So
{"title":"Aged eggs improve within young follicles","authors":"Jing Wang, Chun So","doi":"10.1038/s43587-024-00715-y","DOIUrl":"10.1038/s43587-024-00715-y","url":null,"abstract":"Wang and colleagues investigate the effects of the follicular microenvironment on egg aging in mouse and demonstrate that it is possible to rejuvenate aged eggs by exposing them to a young follicular microenvironment.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoma lurks within aged B cells 老化的 B 细胞中潜伏着淋巴瘤。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00714-z
Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero
{"title":"Lymphoma lurks within aged B cells","authors":"Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero","doi":"10.1038/s43587-024-00714-z","DOIUrl":"10.1038/s43587-024-00714-z","url":null,"abstract":"Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total physical activity matters for brain health 全面的体育锻炼对大脑健康至关重要。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00712-1
Kaarin J. Anstey
{"title":"Total physical activity matters for brain health","authors":"Kaarin J. Anstey","doi":"10.1038/s43587-024-00712-1","DOIUrl":"10.1038/s43587-024-00712-1","url":null,"abstract":"Many people struggle to be physically active during the week. Research now shows that accumulating the recommended amount of physical activity within a shorter time period, such as the weekend, has benefits for brain health equal to those of a regular physical activity pattern, and that this reduces risk of brain disorders, depression and anxiety.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leonard Hayflick (1928–2024) 伦纳德-海弗里克（1928-2024）。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00720-1
Michael D. West, João Pedro de Magalhães, S. Jay Olshansky
{"title":"Leonard Hayflick (1928–2024)","authors":"Michael D. West, João Pedro de Magalhães, S. Jay Olshansky","doi":"10.1038/s43587-024-00720-1","DOIUrl":"10.1038/s43587-024-00720-1","url":null,"abstract":"Pioneer of cell aging research and discoverer of the Hayflick limit.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00720-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Older age reduces mtDNA mutation inheritance. 作者更正：高龄会降低 mtDNA 变异的遗传性。
IF 17
Nature aging Pub Date : 2024-09-23 DOI: 10.1038/s43587-024-00726-9
Polyxeni Papadea, Nils-Göran Larsson
{"title":"Author Correction: Older age reduces mtDNA mutation inheritance.","authors":"Polyxeni Papadea, Nils-Göran Larsson","doi":"10.1038/s43587-024-00726-9","DOIUrl":"https://doi.org/10.1038/s43587-024-00726-9","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probabilistic inference of epigenetic age acceleration from cellular dynamics 从细胞动力学推断表观遗传年龄加速的概率。
IF 17
Nature aging Pub Date : 2024-09-23 DOI: 10.1038/s43587-024-00700-5
Jan K. Dabrowski, Emma J. Yang, Samuel J. C. Crofts, Robert F. Hillary, Daniel J. Simpson, Daniel L. McCartney, Riccardo E. Marioni, Kristina Kirschner, Eric Latorre-Crespo, Tamir Chandra
{"title":"Probabilistic inference of epigenetic age acceleration from cellular dynamics","authors":"Jan K. Dabrowski, Emma J. Yang, Samuel J. C. Crofts, Robert F. Hillary, Daniel J. Simpson, Daniel L. McCartney, Riccardo E. Marioni, Kristina Kirschner, Eric Latorre-Crespo, Tamir Chandra","doi":"10.1038/s43587-024-00700-5","DOIUrl":"10.1038/s43587-024-00700-5","url":null,"abstract":"The emergence of epigenetic predictors was a pivotal moment in geroscience, propelling the measurement and concept of biological aging into a quantitative era; however, while current epigenetic clocks show strong predictive power, they are data-driven in nature and are not based on the underlying biological mechanisms driving methylation dynamics. We show that predictions of these clocks are susceptible to several confounding non-age-related phenomena that make interpretation of these estimates and associations difficult. To address these limitations, we developed a probabilistic model describing methylation transitions at the cellular level. Our approach reveals two measurable components, acceleration and bias, which directly reflect perturbations of the underlying cellular dynamics. Acceleration is the proportional increase in the speed of methylation transitions across CpG sites, whereas bias corresponds to global changes in methylation levels. Using data from 15,900 participants from the Generation Scotland study, we develop a robust inference framework and show that these are two distinct processes confounding current epigenetic predictors. Our results show improved associations of acceleration and bias with physiological traits known to impact healthy aging, such as smoking and alcohol consumption, respectively. Furthermore, a genome-wide association study of epigenetic age acceleration identified seven genomic loci. Epigenetic clocks estimate biological age; however, the underlying processes are incompletely understood. Here the authors developed a model that describes methylation changes at the cellular level to provide a biologically interpretable predictor of epigenetic age. They reveal acceleration and bias components, and links with health traits.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00700-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum protein patterns are associated with future diagnosis of Alzheimer’s disease 血清蛋白模式与阿尔茨海默病的未来诊断有关。
IF 17
Nature aging Pub Date : 2024-09-20 DOI: 10.1038/s43587-024-00723-y
{"title":"Serum protein patterns are associated with future diagnosis of Alzheimer’s disease","authors":"","doi":"10.1038/s43587-024-00723-y","DOIUrl":"10.1038/s43587-024-00723-y","url":null,"abstract":"Insights into the Alzheimer’s disease blood proteome from a population-based cohort show how the serum levels of certain proteins change prior to diagnosis, how they overlap with signature changes in disease-relevant tissues, and how the association between certain proteins and the disease markedly shifts according to APOE-ε4 carrier status.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease 作者更正：血清蛋白质组学揭示阿尔茨海默病中依赖 APOE-ε4 和不依赖 APOE-ε4 的蛋白质特征
IF 17
Nature aging Pub Date : 2024-09-16 DOI: 10.1038/s43587-024-00718-9
Elisabet A. Frick, Valur Emilsson, Thorarinn Jonmundsson, Anna E. Steindorsdottir, Erik C. B. Johnson, Raquel Puerta, Eric B. Dammer, Anantharaman Shantaraman, Amanda Cano, Mercè Boada, Sergi Valero, Pablo García-González, Elias F. Gudmundsson, Alexander Gudjonsson, Rebecca Pitts, Xiazi Qiu, Nancy Finkel, Joseph J. Loureiro, Anthony P. Orth, Nicholas T. Seyfried, Allan I. Levey, Agustin Ruiz, Thor Aspelund, Lori L. Jennings, Lenore J. Launer, Valborg Gudmundsdottir, Vilmundur Gudnason
{"title":"Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease","authors":"Elisabet A. Frick, Valur Emilsson, Thorarinn Jonmundsson, Anna E. Steindorsdottir, Erik C. B. Johnson, Raquel Puerta, Eric B. Dammer, Anantharaman Shantaraman, Amanda Cano, Mercè Boada, Sergi Valero, Pablo García-González, Elias F. Gudmundsson, Alexander Gudjonsson, Rebecca Pitts, Xiazi Qiu, Nancy Finkel, Joseph J. Loureiro, Anthony P. Orth, Nicholas T. Seyfried, Allan I. Levey, Agustin Ruiz, Thor Aspelund, Lori L. Jennings, Lenore J. Launer, Valborg Gudmundsdottir, Vilmundur Gudnason","doi":"10.1038/s43587-024-00718-9","DOIUrl":"10.1038/s43587-024-00718-9","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00718-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and recommendations for the translation of biomarkers of aging 老龄化生物标志物转化的挑战和建议。
IF 17
Nature aging Pub Date : 2024-09-16 DOI: 10.1038/s43587-024-00683-3
Biomarkers of Aging Consortium, Chiara M. S. Herzog, Ludger J. E. Goeminne, Jesse R. Poganik, Nir Barzilai, Daniel W. Belsky, Joe Betts-LaCroix, Brian H. Chen, Michelle Chen, Alan A. Cohen, Steven R. Cummings, Peter O. Fedichev, Luigi Ferrucci, Alexander Fleming, Kristen Fortney, David Furman, Vera Gorbunova, Albert Higgins-Chen, Lee Hood, Steve Horvath, Jamie N. Justice, Douglas P. Kiel, George A. Kuchel, Jessica Lasky-Su, Nathan K. LeBrasseur, Andrea B. Maier, Birgit Schilling, Vittorio Sebastiano, P. Eline Slagboom, Michael P. Snyder, Eric Verdin, Martin Widschwendter, Alex Zhavoronkov, Mahdi Moqri, Vadim N. Gladyshev
{"title":"Challenges and recommendations for the translation of biomarkers of aging","authors":"Biomarkers of Aging Consortium, Chiara M. S. Herzog, Ludger J. E. Goeminne, Jesse R. Poganik, Nir Barzilai, Daniel W. Belsky, Joe Betts-LaCroix, Brian H. Chen, Michelle Chen, Alan A. Cohen, Steven R. Cummings, Peter O. Fedichev, Luigi Ferrucci, Alexander Fleming, Kristen Fortney, David Furman, Vera Gorbunova, Albert Higgins-Chen, Lee Hood, Steve Horvath, Jamie N. Justice, Douglas P. Kiel, George A. Kuchel, Jessica Lasky-Su, Nathan K. LeBrasseur, Andrea B. Maier, Birgit Schilling, Vittorio Sebastiano, P. Eline Slagboom, Michael P. Snyder, Eric Verdin, Martin Widschwendter, Alex Zhavoronkov, Mahdi Moqri, Vadim N. Gladyshev","doi":"10.1038/s43587-024-00683-3","DOIUrl":"10.1038/s43587-024-00683-3","url":null,"abstract":"Biomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings. We surveyed experts in these areas to better understand current challenges for the translation of aging biomarkers. We identified six key barriers to clinical translation and developed guidance for the field to overcome them. Core recommendations include linking BOA to clinically actionable insights, improving affordability and availability to broad populations and validation of biomarkers that are robust and responsive at the level of individuals. Our work provides key insights and practical recommendations to overcome barriers impeding clinical translation of BOA. Biomarkers of aging have potential to accelerate the clinical translation of interventions that promote healthy aging but are currently limited to research. The authors identify six barriers to be overcome to enable biomarker translation, providing a roadmap to clinical implementation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incompetent neck valves threaten the aging brain 不健全的颈部瓣膜威胁老化的大脑
IF 17
Nature aging Pub Date : 2024-09-11 DOI: 10.1038/s43587-024-00707-y
Monica M. Santisteban, Costantino Iadecola
{"title":"Incompetent neck valves threaten the aging brain","authors":"Monica M. Santisteban, Costantino Iadecola","doi":"10.1038/s43587-024-00707-y","DOIUrl":"10.1038/s43587-024-00707-y","url":null,"abstract":"Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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