Nature aging最新文献

{"title":"Physical activity delays ovarian aging in part through adiponectin-related signaling pathways.","authors":"Biao Li, Nana Zheng, Tong Luo, Yueqi Chen, Xionge Mei, Qiyuan Huang, Wei Wang, Longyan Li, Lincheng Han, Wanying Wang, Bingqin Lin, Yimei Fan, Yaping Liu, Zili Liu, Sizhi Ai, Yannis Yan Liang, Han Wang, Xiao Tan, Meijia Zhang, Hongliang Feng, Jihui Zhang","doi":"10.1038/s43587-026-01177-0","DOIUrl":"https://doi.org/10.1038/s43587-026-01177-0","url":null,"abstract":"<p><p>Ovarian aging leads to infertility, endocrine dysregulation and increased chronic disease risk, yet there are currently no approved therapies to delay ovarian aging. Physical activity (PA) is a crucial lifestyle factor for human health and antiaging, but its effects and mechanisms on ovarian aging remain unclear. Here we show, through a cross-sectional analysis of 152,435 participants in the UK Biobank, that lower PA levels were observed among postmenopausal persons when compared to premenopausal persons, and this finding was supported by another cross-sectional study of 12,418 participants in the National Health and Nutrition Examination Survey. Animal studies in mice show that higher levels of PA can delay ovarian aging. In addition, PA significantly increased adiponectin levels in the ovary, and the protective effects of PA on ovarian aging were attenuated in adiponectin-deficient mice. The adiponectin receptor agonist AdipoRon delayed ovarian aging and extended reproductive lifespan in mice. Our findings elucidate the role and mechanisms of PA in delaying ovarian aging, highlighting potential therapeutic targets for extending the reproductive lifespan.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":25.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A National Institute on Aging workshop on sex differences in health across the lifespan.","authors":"Jeffrey Pea, Siobhan Addie, Fabrisia Ambrosio, Rozalyn M Anderson, C Noel Bairey Merz, Elizabeth Barr, Stacy Carrington-Lawrence, Rafael de Cabo, Patrice Desvigne-Nickens, Dena B Dubal, Chelsea Haakenson, Passley Hargove-Grimes, Emily G Jacobs, Mihoko Kai, Maja Maric, Sunila G Nair, Kristy Nicks, Jennifer L Pluznick, Kimberlee Potter, Mercy R Prabhudas, Marta Rodriguez-Garcia, Michael B Stout, Barbara E Stranger, Susan Taymans, Dan Theodorescu, John P Williams, Fei Wang, Xin Yuan, Viviana I Perez, Francesca E Duncan","doi":"10.1038/s43587-026-01194-z","DOIUrl":"https://doi.org/10.1038/s43587-026-01194-z","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":25.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve","authors":"Arturo D’Angelo,&nbsp;Daniel Franco-Barranco,&nbsp;Marco Musy,&nbsp;Juan Manuel Duran,&nbsp;James Sharpe,&nbsp;Nicholas Stroustrup,&nbsp;Ignacio Arganda Carreras,&nbsp;Elvan Böke","doi":"10.1038/s43587-026-01178-z","DOIUrl":"10.1038/s43587-026-01178-z","url":null,"abstract":"Female fertility depends on a finite pool of oocytes that depletes during aging1,2, yet the spatiotemporal dynamics of this depletion remain poorly understood. Traditional methods obscure the three-dimensional architecture of the ovary, limiting quantitative insights. Here we combine light-sheet microscopy, artificial intelligence-driven segmentation and mathematical modeling to map over 85,000 oocytes in whole ovaries across the reproductive lifespan in mouse. We find that newly activated oocytes represent a fixed fraction of the total oocyte pool despite an age-related decline in oocyte numbers. Spatial analysis revealed that oocytes are enriched along the lateral ovarian axis, and local oocyte density positively correlates with activation. We also uncover a bimodal distribution of oocyte sizes, suggesting a bottleneck during oogenesis. Finally, a differential equation-based model captures the kinetics of oocyte activation and loss. Our findings establish a quantitative framework for understanding ovarian aging and suggest that an organ-scale regulatory mechanism coordinates the age-related decline in oocyte numbers. The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and found that ovaries maintain a stable fraction of newly activated oocytes throughout aging, suggesting organ-wide control of oocyte activation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1580-1591"},"PeriodicalIF":25.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s43587-026-01178-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.","authors":"Wei-Chieh Mu, Marine Barthez, Yufan Feng, Yibing Chen, Chih Ling Wang, Jing-Yi Huang, Jie Li, Paul Lanhart, K Claire Tsuei, Yang Joon Kim, Eric Verdin, Mihai G Netea, Danica Chen","doi":"10.1038/s43587-026-01213-z","DOIUrl":"10.1038/s43587-026-01213-z","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":25.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging","authors":"Ruixuan Wang \u0000 (,&nbsp;),&nbsp;Tahmineh Tabrizian,&nbsp;Donghai Wang,&nbsp;Jeb English,&nbsp;Anita Ayer,&nbsp;Maya Gal,&nbsp;Weng-Lang Yang,&nbsp;Zhiping Wu,&nbsp;Kai Mao,&nbsp;Ardijana Novaj,&nbsp;Xusheng Zhang,&nbsp;Indranil Basu,&nbsp;Nils P. Brodin,&nbsp;Wade Koba,&nbsp;Deepak Saxena,&nbsp;Jiahn Choi,&nbsp;Leonard H. Augenlicht,&nbsp;Aaron Ericsson,&nbsp;Evripidis Gavathiotis,&nbsp;Chandan Guha,&nbsp;Derek M. Huffman","doi":"10.1038/s43587-026-01170-7","DOIUrl":"10.1038/s43587-026-01170-7","url":null,"abstract":"Aging is characterized by a decline in function of intestinal stem cells (ISCs), but the extent to which this is shaped by systemic factors is unclear. Here we show that the ISC aging phenotype can be propagated from old to young mice utilizing heterochronic parabiosis, and implicate a role for inflammation in these effects, as anti-inflammatory drugs, including TNF antibodies, restored function. Parabiotic rescue experiments demonstrate that TNFR1 knockout protected young ISCs from the old environment. In young organoids, TNF downregulated crypt budding, while impairing mitochondrial pathways and fatty acid oxidation (FAO). However, aged ISC function was enhanced by boosting mitochondrial fusion, whereas FAO in aged crypts was improved by countering inflammation with salicylate treatment. Thus, these data identify the old environment through the progeronic factor TNF, as a driver of ISC aging phenotypes through intestinal epithelial cell TNF receptor 1 signaling to downregulate FAO, proliferation and regenerative capacity in these cells. Wang et al. identify TNFR1 signaling as a key link between inflammation and intestinal stem cell aging. This aging phenotype is transferable from old to young mice via shared circulation, suggesting systemic inflammation as a target to improve intestinal health.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1631-1646"},"PeriodicalIF":25.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s43587-026-01170-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148710566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging.","authors":"Maziar Divangahi, Katherine Y King","doi":"10.1038/s43587-026-01197-w","DOIUrl":"https://doi.org/10.1038/s43587-026-01197-w","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":25.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FAD is an immune checkpoint metabolite for cGAS and RIG-I","authors":"Hannah Walters","doi":"10.1038/s43587-026-01203-1","DOIUrl":"10.1038/s43587-026-01203-1","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1543-1543"},"PeriodicalIF":25.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social inequalities linked to accelerated biological aging","authors":"Susan Rahimi","doi":"10.1038/s43587-026-01201-3","DOIUrl":"10.1038/s43587-026-01201-3","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1542-1542"},"PeriodicalIF":25.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence","authors":"Jing Hou,&nbsp;Kai-Xuan Chen,&nbsp;Chen He,&nbsp;Xiao-Xiao Li,&nbsp;Mei Huang,&nbsp;Yang-Zi Jiang,&nbsp;Yu-Rui Jiao,&nbsp;Qiao-Ni Xiao,&nbsp;Wen-Zhen He,&nbsp;Ling Liu,&nbsp;Nan-Yu Zou,&nbsp;Min Huang,&nbsp;Jie Wei,&nbsp;Ye Xiao,&nbsp;Mi Yang,&nbsp;Xiang-Hang Luo,&nbsp;Chao Zeng,&nbsp;Guang-Hua Lei,&nbsp;Chang-Jun Li","doi":"10.1038/s43587-026-01208-w","DOIUrl":"10.1038/s43587-026-01208-w","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1-1"},"PeriodicalIF":25.0,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s43587-026-01208-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming","authors":"Aidan R. Cole,&nbsp;Raquel Buj,&nbsp;Apoorva Uboveja,&nbsp;Evan Levasseur,&nbsp;Alexander Tom,&nbsp;Hui Wang,&nbsp;Katarzyna M. Kedziora,&nbsp;Adam Chatoff,&nbsp;Andrea Andress Huacachino,&nbsp;Mariola M. Marcinkiewicz,&nbsp;Amandine Amalric,&nbsp;Baixue Yang,&nbsp;Naveen Kumar Tangudu,&nbsp;Emily Noonan,&nbsp;Jeff Danielson,&nbsp;Miho Naruse,&nbsp;Amal Taher Elhaw,&nbsp;Sierra White,&nbsp;Danyang Li,&nbsp;Callen T. Wallace,&nbsp;Frederick Keeney,&nbsp;Felicia Lazure,&nbsp;Esther Elishaev,&nbsp;Lauren Borho,&nbsp;Hope A. Townsend,&nbsp;Robin D. Dowell,&nbsp;Aaron Clauset,&nbsp;Dorota E. Jazwinska,&nbsp;Matthew S. Laird,&nbsp;Huda Atiya,&nbsp;Denarda Dangaj,&nbsp;Lan G. Coffman,&nbsp;George Tseng,&nbsp;Steffi Oesterreich,&nbsp;Andrew Kossenkov,&nbsp;Qin Liu,&nbsp;Ana P. Gomes,&nbsp;Aditi U. Gurkar,&nbsp;Francisco J. Schopfer,&nbsp;Francesmary Modugno,&nbsp;Simon C. Watkins,&nbsp;Ioannis K. Zervantonakis,&nbsp;Benjamin G. Bitler,&nbsp;Wayne Stallaert,&nbsp;Nadine Hempel,&nbsp;Nathaniel W. Snyder,&nbsp;Katherine M. Aird","doi":"10.1038/s43587-026-01172-5","DOIUrl":"10.1038/s43587-026-01172-5","url":null,"abstract":"Cellular senescence is a consequence of many chemotherapeutics that plays context-dependent roles in cancer. Senescent cells secrete an array of factors collectively known as the senescence-associated secretory phenotype (SASP). Here we show that the cisplatin-induced SASP enhances the detachment of high-grade serous ovarian cancer (HGSOC) cells in vitro and dissemination in vivo. We identify fructose as a metabolic component of the SASP that facilitates cell detachment and show that a high-fructose diet increases HGSOC dissemination in vivo. We identified complex I as the driver of SASP-mediated cell detachment and HGSOC dissemination. Mechanistically, this effect was driven by SASP-mediated inhibition of an NAD+–SIRT–SREBP axis, leading to decreased plasma membrane cholesterol that increased cell detachment. These findings reveal that the SASP reprograms the metabolic microenvironment, promoting metastatic dissemination in a paracrine fashion, and highlight a pro-tumorigenic metabolic effect of fructose in the SASP that may contribute to the high recurrence rate of HGSOC. Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms neighboring cancer cells, enhancing their ability to detach by reducing plasma membrane cholesterol through modulation of complex I and NAD.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"6 8","pages":"1647-1666"},"PeriodicalIF":25.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s43587-026-01172-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}