Nature aging最新文献_第3页

Balancing the promise and risks of geroscience interventions 平衡地球科学干预措施的前景与风险。

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Nature aging Pub Date : 2025-01-03 DOI: 10.1038/s43587-024-00788-9

Alan A. Cohen, John R. Beard, Luigi Ferrucci, Tamàs Fülöp, Vadim N. Gladyshev, Mahdi Moqri, Marcel G. M. Olde Rikkert, Martin Picard

引用次数: 0

Author Correction: Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring. 作者更正：女性和男性生殖特征的遗传学及其与健康、寿命和后代后果的关系。

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Nature aging Pub Date : 2025-01-02 DOI: 10.1038/s43587-024-00800-2

Stefania Benonisdottir, Vincent J Straub, Augustine Kong, Melinda C Mills

引用次数: 0

Chronic stress induces senescence build-up early in life 慢性压力会在生命早期引起衰老。

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Nature aging Pub Date : 2025-01-02 DOI: 10.1038/s43587-024-00774-1

Victor Lau, Ifeoluwa Awogbindin, Marie-Ève Tremblay

引用次数: 0

Restoring aging-related tissue homeostasis via reactivated innate immunotherapy 通过再激活先天免疫疗法恢复衰老相关组织的稳态。

IF 17

Nature aging Pub Date : 2025-01-02 DOI: 10.1038/s43587-024-00782-1

引用次数: 0

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging. 基于神经节苷脂的免疫检查点使衰老细胞在衰老过程中逃避免疫监视。

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Nature aging Pub Date : 2024-12-27 DOI: 10.1038/s43587-024-00776-z

Charlène Iltis, Iryna Moskalevska, Antoine Debiesse, Laetitia Seguin, Christina Fissoun, Ludovic Cervera, Lyvia Moudombi, Maude Ardin, Anthony Ferrari, Coline Eliott, Didier Pisani, Alexandre Ottaviani, Manon Bourinet, Carmelo Luci, Philippe Gual, Gabriela Makulyte, David Bernard, Manon Durandy, Lou C Duret, Tynhinane Hamidouche, Sarah Kunz, Olivier Croce, Clément Delannoy, Yann Guérardel, Fabrice Allain, Paul Hofman, Delphine Benarroch-Popivker, Laurence Bianchini, Berengère Dadone-Montaudie, Estelle Cosson, Julien Guglielmi, Thierry Pourcher, Véronique M Braud, Marina Shkreli, Yves-Marie Pers, Christian Jorgensen, Jean-Marc Brondello, Chloé C Féral, Marie-Cécile Michallet, Eric Gilson, Julien Cherfils-Vicini

{"title":"A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging.","authors":"Charlène Iltis, Iryna Moskalevska, Antoine Debiesse, Laetitia Seguin, Christina Fissoun, Ludovic Cervera, Lyvia Moudombi, Maude Ardin, Anthony Ferrari, Coline Eliott, Didier Pisani, Alexandre Ottaviani, Manon Bourinet, Carmelo Luci, Philippe Gual, Gabriela Makulyte, David Bernard, Manon Durandy, Lou C Duret, Tynhinane Hamidouche, Sarah Kunz, Olivier Croce, Clément Delannoy, Yann Guérardel, Fabrice Allain, Paul Hofman, Delphine Benarroch-Popivker, Laurence Bianchini, Berengère Dadone-Montaudie, Estelle Cosson, Julien Guglielmi, Thierry Pourcher, Véronique M Braud, Marina Shkreli, Yves-Marie Pers, Christian Jorgensen, Jean-Marc Brondello, Chloé C Féral, Marie-Cécile Michallet, Eric Gilson, Julien Cherfils-Vicini","doi":"10.1038/s43587-024-00776-z","DOIUrl":"10.1038/s43587-024-00776-z","url":null,"abstract":"Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance. In mice, we found that targeting GD3+ senescent cells with anti-GD3 immunotherapy attenuated the development of experimentally induced or age-related lung and liver fibrosis and age-related bone remodeling. These results demonstrate that GD3 upregulation confers immune privilege to senescent cells. We propose that GD3 acts as a senescence immune checkpoint (SIC) that allows senescent cells to escape immunosurveillance and to trigger immune anergy during aging.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog 利用胶束包裹的苏丹黑 B 共轭类似物生成选择性衰老分解平台。

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Nature aging Pub Date : 2024-12-27 DOI: 10.1038/s43587-024-00747-4

Sophia Magkouta, Dimitris Veroutis, Angelos Papaspyropoulos, Maria Georgiou, Nikolaos Lougiakis, Natassa Pippa, Sophia Havaki, Anastasia Palaiologou, Dimitris-Foivos Thanos, Konstantinos Kambas, Nefeli Lagopati, Nikos Boukos, Nicole Pouli, Panagiotis Marakos, Athanassios Kotsinas, Dimitris Thanos, Konstantinos Evangelou, Fotios Sampaziotis, Constantin Tamvakopoulos, Stergios Pispas, Russell Petty, Nicholas Kotopoulos, Vassilis G. Gorgoulis

{"title":"Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog","authors":"Sophia Magkouta, Dimitris Veroutis, Angelos Papaspyropoulos, Maria Georgiou, Nikolaos Lougiakis, Natassa Pippa, Sophia Havaki, Anastasia Palaiologou, Dimitris-Foivos Thanos, Konstantinos Kambas, Nefeli Lagopati, Nikos Boukos, Nicole Pouli, Panagiotis Marakos, Athanassios Kotsinas, Dimitris Thanos, Konstantinos Evangelou, Fotios Sampaziotis, Constantin Tamvakopoulos, Stergios Pispas, Russell Petty, Nicholas Kotopoulos, Vassilis G. Gorgoulis","doi":"10.1038/s43587-024-00747-4","DOIUrl":"10.1038/s43587-024-00747-4","url":null,"abstract":"The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging. Enhancing the selectivity of senolytic treatments toward senescent cells stands to reduce the adverse effects associated with existing senolytic interventions. Taking advantage of lipofuscin accumulation in senescent cells, we describe here the development of a highly efficient senolytic platform consisting of a lipofuscin-binding domain scaffold, which can be conjugated with a senolytic drug via an ester bond. As a proof of concept, we present the generation of GL392, a senolytic compound that carries a dasatinib senolytic moiety. Encapsulation of the GL392 compound in a micelle nanocarrier (termed mGL392) allows for both in vitro and in vivo (in mice) selective elimination of senescent cells via targeted release of the senolytic agent with minimal systemic toxicity. Our findings suggest that this platform could be used to enhance targeting of senotherapeutics toward senescent cells. Exploiting the selective accumulation of lipofuscin in senescent cells, the authors developed a targeted senolytic platform. As proof of concept, they show that selective delivery of dasatinib elicits senolysis with minimal toxicity, in vitro, in organoids and in mice.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"162-175"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00747-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas. 结构性不平等与美洲老龄化和痴呆症的脑容量和网络动态有关。

IF 17

Nature aging Pub Date : 2024-12-27 DOI: 10.1038/s43587-024-00781-2

Agustina Legaz, Florencia Altschuler, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Vicente Medel, Marcelo Adrián Maito, María E Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazuchi, Hernando Santamaria Garcia, Francesca R Farina, Pablo Reyes, Shireen Javandel, Adolfo M García, Álvaro Deleglise, Diana L Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I Behrens, Nilton Custodio, Catalina Trujillo-Llano, Juan F Cardona, Pablo Barttfeld, Ignacio L Brusco, Martín A Bruno, Ana L Sosa Ortiz, Stefanie D Pina-Escudero, Leonel T Takada, Elisa de Paula França Resende, Katherine L Possin, Maira Okada de Oliveira, Kun Hu, Francisco Lopera, Brian Lawlor, Victor Valcour, Jennifer S Yokoyama, Bruce Miller, Agustin Ibañez

{"title":"Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas.","authors":"Agustina Legaz, Florencia Altschuler, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Vicente Medel, Marcelo Adrián Maito, María E Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazuchi, Hernando Santamaria Garcia, Francesca R Farina, Pablo Reyes, Shireen Javandel, Adolfo M García, Álvaro Deleglise, Diana L Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I Behrens, Nilton Custodio, Catalina Trujillo-Llano, Juan F Cardona, Pablo Barttfeld, Ignacio L Brusco, Martín A Bruno, Ana L Sosa Ortiz, Stefanie D Pina-Escudero, Leonel T Takada, Elisa de Paula França Resende, Katherine L Possin, Maira Okada de Oliveira, Kun Hu, Francisco Lopera, Brian Lawlor, Victor Valcour, Jennifer S Yokoyama, Bruce Miller, Agustin Ibañez","doi":"10.1038/s43587-024-00781-2","DOIUrl":"10.1038/s43587-024-00781-2","url":null,"abstract":"Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer's disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer's disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global analysis of adaptation to societal aging across low-, middle- and high-income countries using the Global Aging Society Index 使用全球老龄化社会指数对低、中、高收入国家适应社会老龄化的全球分析。

IF 17

Nature aging Pub Date : 2024-12-27 DOI: 10.1038/s43587-024-00772-3

Cynthia Chen, Julian Lim, Jemima Koh, John Beard, John W. Rowe, for the Research Network on an Aging Society

{"title":"A global analysis of adaptation to societal aging across low-, middle- and high-income countries using the Global Aging Society Index","authors":"Cynthia Chen, Julian Lim, Jemima Koh, John Beard, John W. Rowe, for the Research Network on an Aging Society","doi":"10.1038/s43587-024-00772-3","DOIUrl":"10.1038/s43587-024-00772-3","url":null,"abstract":"We have previously presented a multidimensional Aging Society Index, a weighted summation of five domains central to successful adaptation to societal aging: well-being, productivity and engagement, equity, cohesion and security, as a tool to assess countries’ adaptation to demographic transformation. As the index was based on data from developed countries and some of the individual metrics or weightings may not be well suited for application to low- and middle-income countries, we here present the scores on a modified index (Global Aging Society Index) on 143 countries distributed across the span of economic development. Only 5 out of 143 (3.5%) countries had higher scores for women than men. Countries with the most notable gender differences were primarily low-income countries. The multidimensional index permits cross-national comparisons and may facilitate the identification of targets for developing policies and programs to enhance the likelihood that older persons will age successfully. The authors score and rank the adaptation to societal aging across 143 countries using a newly developed index called the Global Aging Society Index, which may be helpful to identify targets for the development of policies and programs to enhance the likelihood that older people will age successfully.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"113-121"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00772-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cohort trends in intrinsic capacity in England and China 英国和中国内在能力的队列趋势。

IF 17

Nature aging Pub Date : 2024-12-19 DOI: 10.1038/s43587-024-00741-w

John R. Beard, Katja Hanewald, Yafei Si, Jotheeswaran Amuthavalli Thiyagarajan, Dario Moreno-Agostino

{"title":"Cohort trends in intrinsic capacity in England and China","authors":"John R. Beard, Katja Hanewald, Yafei Si, Jotheeswaran Amuthavalli Thiyagarajan, Dario Moreno-Agostino","doi":"10.1038/s43587-024-00741-w","DOIUrl":"10.1038/s43587-024-00741-w","url":null,"abstract":"To understand how the health of older adults today compares to that of previous generations, we estimated intrinsic capacity and subdomains of cognitive, locomotor, sensory, psychological and vitality capacities in participants of the English Longitudinal Study of Ageing and the China Health and Retirement Longitudinal Study. Applying multilevel growth curve models, we found that more recent cohorts entered older ages with higher levels of capacity, while subsequent age-related declines were somewhat compressed compared to earlier cohorts. Trends were most evident for the cognitive, locomotor and vitality capacities. Improvements were large, with the greatest gains being in the most recent cohorts. For example, a 68-year-old participant of the English Longitudinal Study of Ageing born in 1950 had higher capacity than a 62-year-old born 10 years earlier. Trends were similar for men and women and were generally consistent across English and Chinese cohorts. Possible causes include broad societal influences and improvements in medical care. Intrinsic capacity includes a person’s mental and physical capacities. The authors examined cohort trends in intrinsic capacity in two large English and Chinese studies. They report that more recently born participants entered older ages with markedly higher levels of functioning, while subsequent age-related declines were somewhat delayed.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"87-98"},"PeriodicalIF":17.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00741-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supporting the sexual healthcare needs of aging women 支持老年妇女的性保健需求

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00725-w

Holly N. Thomas

引用次数: 0