{"title":"血液DNA甲基化测试揭示了每个器官系统衰老的速度。","authors":"","doi":"10.1038/s43587-025-00959-2","DOIUrl":null,"url":null,"abstract":"We developed a single blood-based methylation test that estimates biological aging across 11 physiological systems. This multisystem measure predicts mortality and health outcomes more precisely than existing epigenetic clocks, and reveals distinct aging patterns that could guide personalized gerotherapeutic and geroprotective interventions.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 9","pages":"1665-1666"},"PeriodicalIF":19.4000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A blood DNA methylation test reveals how quickly each organ system is aging\",\"authors\":\"\",\"doi\":\"10.1038/s43587-025-00959-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We developed a single blood-based methylation test that estimates biological aging across 11 physiological systems. This multisystem measure predicts mortality and health outcomes more precisely than existing epigenetic clocks, and reveals distinct aging patterns that could guide personalized gerotherapeutic and geroprotective interventions.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 9\",\"pages\":\"1665-1666\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00959-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00959-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
A blood DNA methylation test reveals how quickly each organ system is aging
We developed a single blood-based methylation test that estimates biological aging across 11 physiological systems. This multisystem measure predicts mortality and health outcomes more precisely than existing epigenetic clocks, and reveals distinct aging patterns that could guide personalized gerotherapeutic and geroprotective interventions.
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