Nature agingPub Date : 2024-10-07DOI: 10.1038/s43587-024-00702-3
S. Jay Olshansky, Bradley J. Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez
{"title":"Implausibility of radical life extension in humans in the twenty-first century","authors":"S. Jay Olshansky, Bradley J. Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez","doi":"10.1038/s43587-024-00702-3","DOIUrl":"10.1038/s43587-024-00702-3","url":null,"abstract":"Over the course of the twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven by advances in public health and medicine. Mortality reduction was observed initially at an early age and continued into middle and older ages. However, it was unclear whether this phenomenon and the resulting accelerated rise in life expectancy would continue into the twenty-first century. Here using demographic survivorship metrics from national vital statistics in the eight countries with the longest-lived populations (Australia, France, Italy, Japan, South Korea, Spain, Sweden and Switzerland) and in Hong Kong and the United States from 1990 to 2019, we explored recent trends in death rates and life expectancy. We found that, since 1990, improvements overall in life expectancy have decelerated. Our analysis also revealed that resistance to improvements in life expectancy increased while lifespan inequality declined and mortality compression occurred. Our analysis suggests that survival to age 100 years is unlikely to exceed 15% for females and 5% for males, altogether suggesting that, unless the processes of biological aging can be markedly slowed, radical human life extension is implausible in this century. In the twentieth century, human life expectancy rose dramatically. Based on the past three decades of observed mortality in the eight countries with the longest-lived populations and in Hong Kong and the United States, Olshansky et al. propose that, without medical breakthroughs that slow aging, radical lifespan extension is implausible in this century.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 11","pages":"1635-1642"},"PeriodicalIF":17.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00702-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2024-10-07DOI: 10.1038/s43587-024-00722-z
Dmitri Jdanov, Domantas Jasilionis
{"title":"Optimistic versus pessimistic scenarios for future life expectancy","authors":"Dmitri Jdanov, Domantas Jasilionis","doi":"10.1038/s43587-024-00722-z","DOIUrl":"10.1038/s43587-024-00722-z","url":null,"abstract":"There was a radical increase in record human life expectancy during the 20th century. A study by Olshansky et al., however, now suggests that similar progress in the 21st century is unlikely. Although further advances will be difficult to achieve, more optimistic alternative scenarios should also be considered that rely on historical evidence and experiences of vanguard groups at the subnational level.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 11","pages":"1524-1526"},"PeriodicalIF":17.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2024-10-01DOI: 10.1038/s43587-024-00715-y
Jing Wang, Chun So
{"title":"Aged eggs improve within young follicles","authors":"Jing Wang, Chun So","doi":"10.1038/s43587-024-00715-y","DOIUrl":"10.1038/s43587-024-00715-y","url":null,"abstract":"Wang and colleagues investigate the effects of the follicular microenvironment on egg aging in mouse and demonstrate that it is possible to rejuvenate aged eggs by exposing them to a young follicular microenvironment.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1338-1339"},"PeriodicalIF":17.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2024-09-30DOI: 10.1038/s43587-024-00714-z
Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero
{"title":"Lymphoma lurks within aged B cells","authors":"Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero","doi":"10.1038/s43587-024-00714-z","DOIUrl":"10.1038/s43587-024-00714-z","url":null,"abstract":"Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1343-1345"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2024-09-30DOI: 10.1038/s43587-024-00712-1
Kaarin J. Anstey
{"title":"Total physical activity matters for brain health","authors":"Kaarin J. Anstey","doi":"10.1038/s43587-024-00712-1","DOIUrl":"10.1038/s43587-024-00712-1","url":null,"abstract":"Many people struggle to be physically active during the week. Research now shows that accumulating the recommended amount of physical activity within a shorter time period, such as the weekend, has benefits for brain health equal to those of a regular physical activity pattern, and that this reduces risk of brain disorders, depression and anxiety.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1340-1342"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2024-09-30DOI: 10.1038/s43587-024-00720-1
Michael D. West, João Pedro de Magalhães, S. Jay Olshansky
{"title":"Leonard Hayflick (1928–2024)","authors":"Michael D. West, João Pedro de Magalhães, S. Jay Olshansky","doi":"10.1038/s43587-024-00720-1","DOIUrl":"10.1038/s43587-024-00720-1","url":null,"abstract":"Pioneer of cell aging research and discoverer of the Hayflick limit.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1329-1330"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00720-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}