Nature aging最新文献

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Immune aging impairs tumor control 免疫老化损害肿瘤控制
IF 17
Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00737-6
Hannah Walters
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引用次数: 0
Implausibility of radical life extension in humans in the twenty-first century 二十一世纪人类彻底延长寿命的不可能性。
IF 17
Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00702-3
S. Jay Olshansky, Bradley J. Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez
{"title":"Implausibility of radical life extension in humans in the twenty-first century","authors":"S. Jay Olshansky, Bradley J. Willcox, Lloyd Demetrius, Hiram Beltrán-Sánchez","doi":"10.1038/s43587-024-00702-3","DOIUrl":"10.1038/s43587-024-00702-3","url":null,"abstract":"Over the course of the twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven by advances in public health and medicine. Mortality reduction was observed initially at an early age and continued into middle and older ages. However, it was unclear whether this phenomenon and the resulting accelerated rise in life expectancy would continue into the twenty-first century. Here using demographic survivorship metrics from national vital statistics in the eight countries with the longest-lived populations (Australia, France, Italy, Japan, South Korea, Spain, Sweden and Switzerland) and in Hong Kong and the United States from 1990 to 2019, we explored recent trends in death rates and life expectancy. We found that, since 1990, improvements overall in life expectancy have decelerated. Our analysis also revealed that resistance to improvements in life expectancy increased while lifespan inequality declined and mortality compression occurred. Our analysis suggests that survival to age 100 years is unlikely to exceed 15% for females and 5% for males, altogether suggesting that, unless the processes of biological aging can be markedly slowed, radical human life extension is implausible in this century. In the twentieth century, human life expectancy rose dramatically. Based on the past three decades of observed mortality in the eight countries with the longest-lived populations and in Hong Kong and the United States, Olshansky et al. propose that, without medical breakthroughs that slow aging, radical lifespan extension is implausible in this century.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 11","pages":"1635-1642"},"PeriodicalIF":17.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00702-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimistic versus pessimistic scenarios for future life expectancy 未来预期寿命的乐观与悲观情景。
IF 17
Nature aging Pub Date : 2024-10-07 DOI: 10.1038/s43587-024-00722-z
Dmitri Jdanov, Domantas Jasilionis
{"title":"Optimistic versus pessimistic scenarios for future life expectancy","authors":"Dmitri Jdanov, Domantas Jasilionis","doi":"10.1038/s43587-024-00722-z","DOIUrl":"10.1038/s43587-024-00722-z","url":null,"abstract":"There was a radical increase in record human life expectancy during the 20th century. A study by Olshansky et al., however, now suggests that similar progress in the 21st century is unlikely. Although further advances will be difficult to achieve, more optimistic alternative scenarios should also be considered that rely on historical evidence and experiences of vanguard groups at the subnational level.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 11","pages":"1524-1526"},"PeriodicalIF":17.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital reminders improve vaccination rates 数字提醒可提高疫苗接种率。
IF 17
Nature aging Pub Date : 2024-10-04 DOI: 10.1038/s43587-024-00736-7
George Andrew S. Inglis
{"title":"Digital reminders improve vaccination rates","authors":"George Andrew S. Inglis","doi":"10.1038/s43587-024-00736-7","DOIUrl":"10.1038/s43587-024-00736-7","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1336-1336"},"PeriodicalIF":17.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex dimorphism in the aged melanoma microenvironment 老年黑色素瘤微环境中的性别双态性。
IF 17
Nature aging Pub Date : 2024-10-04 DOI: 10.1038/s43587-024-00729-6
Jean Nakhle
{"title":"Sex dimorphism in the aged melanoma microenvironment","authors":"Jean Nakhle","doi":"10.1038/s43587-024-00729-6","DOIUrl":"10.1038/s43587-024-00729-6","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1335-1335"},"PeriodicalIF":17.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aged eggs improve within young follicles 老化的卵子在年轻的卵泡内会得到改善。
IF 17
Nature aging Pub Date : 2024-10-01 DOI: 10.1038/s43587-024-00715-y
Jing Wang, Chun So
{"title":"Aged eggs improve within young follicles","authors":"Jing Wang, Chun So","doi":"10.1038/s43587-024-00715-y","DOIUrl":"10.1038/s43587-024-00715-y","url":null,"abstract":"Wang and colleagues investigate the effects of the follicular microenvironment on egg aging in mouse and demonstrate that it is possible to rejuvenate aged eggs by exposing them to a young follicular microenvironment.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1338-1339"},"PeriodicalIF":17.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoma lurks within aged B cells 老化的 B 细胞中潜伏着淋巴瘤。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00714-z
Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero
{"title":"Lymphoma lurks within aged B cells","authors":"Raúl F. Pérez, Víctor Jiménez-Martínez, José I. Martín-Subero","doi":"10.1038/s43587-024-00714-z","DOIUrl":"10.1038/s43587-024-00714-z","url":null,"abstract":"Cancer and aging are inextricably linked conditions. However, whether cancer emerges as a byproduct of the aging process or whether aged cells themselves are prone to become neoplastic remains enigmatic. A study by Castro, Shindyapina and colleagues now provides support for the latter by demonstrating that in aged mice that spontaneously develop lymphomas, tumors originate from clonally expanded age-associated B cells.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1343-1345"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total physical activity matters for brain health 全面的体育锻炼对大脑健康至关重要。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00712-1
Kaarin J. Anstey
{"title":"Total physical activity matters for brain health","authors":"Kaarin J. Anstey","doi":"10.1038/s43587-024-00712-1","DOIUrl":"10.1038/s43587-024-00712-1","url":null,"abstract":"Many people struggle to be physically active during the week. Research now shows that accumulating the recommended amount of physical activity within a shorter time period, such as the weekend, has benefits for brain health equal to those of a regular physical activity pattern, and that this reduces risk of brain disorders, depression and anxiety.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1340-1342"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leonard Hayflick (1928–2024) 伦纳德-海弗里克(1928-2024)。
IF 17
Nature aging Pub Date : 2024-09-30 DOI: 10.1038/s43587-024-00720-1
Michael D. West, João Pedro de Magalhães, S. Jay Olshansky
{"title":"Leonard Hayflick (1928–2024)","authors":"Michael D. West, João Pedro de Magalhães, S. Jay Olshansky","doi":"10.1038/s43587-024-00720-1","DOIUrl":"10.1038/s43587-024-00720-1","url":null,"abstract":"Pioneer of cell aging research and discoverer of the Hayflick limit.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 10","pages":"1329-1330"},"PeriodicalIF":17.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00720-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Older age reduces mtDNA mutation inheritance. 作者更正:高龄会降低 mtDNA 变异的遗传性。
IF 17
Nature aging Pub Date : 2024-09-23 DOI: 10.1038/s43587-024-00726-9
Polyxeni Papadea, Nils-Göran Larsson
{"title":"Author Correction: Older age reduces mtDNA mutation inheritance.","authors":"Polyxeni Papadea, Nils-Göran Larsson","doi":"10.1038/s43587-024-00726-9","DOIUrl":"https://doi.org/10.1038/s43587-024-00726-9","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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