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Incompetent neck valves threaten the aging brain 不健全的颈部瓣膜威胁老化的大脑
IF 17
Nature aging Pub Date : 2024-09-11 DOI: 10.1038/s43587-024-00707-y
Monica M. Santisteban, Costantino Iadecola
{"title":"Incompetent neck valves threaten the aging brain","authors":"Monica M. Santisteban, Costantino Iadecola","doi":"10.1038/s43587-024-00707-y","DOIUrl":"10.1038/s43587-024-00707-y","url":null,"abstract":"Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: A plasma protein-based risk score to predict hip fractures 出版商更正：预测髋部骨折的血浆蛋白风险评分。
IF 17
Nature aging Pub Date : 2024-09-10 DOI: 10.1038/s43587-024-00717-w
Thomas R. Austin, Maria Nethander, Howard A. Fink, Anna E. Törnqvist, Diana I. Jalal, Petra Buzkova, Joshua I. Barzilay, Laura Carbone, Maiken E. Gabrielsen, Louise Grahnemo, Tianyuan Lu, Kristian Hveem, Christian Jonasson, Jorge R. Kizer, Arnulf Langhammer, Kenneth J. Mukamal, Robert E. Gerszten, Bruce M. Psaty, John A. Robbins, Yan V. Sun, Anne Heidi Skogholt, John A. Kanis, Helena Johansson, Bjørn Olav Åsvold, Rodrigo J. Valderrabano, Jie Zheng, J. Brent Richards, Eivind Coward, Claes Ohlsson
{"title":"Publisher Correction: A plasma protein-based risk score to predict hip fractures","authors":"Thomas R. Austin, Maria Nethander, Howard A. Fink, Anna E. Törnqvist, Diana I. Jalal, Petra Buzkova, Joshua I. Barzilay, Laura Carbone, Maiken E. Gabrielsen, Louise Grahnemo, Tianyuan Lu, Kristian Hveem, Christian Jonasson, Jorge R. Kizer, Arnulf Langhammer, Kenneth J. Mukamal, Robert E. Gerszten, Bruce M. Psaty, John A. Robbins, Yan V. Sun, Anne Heidi Skogholt, John A. Kanis, Helena Johansson, Bjørn Olav Åsvold, Rodrigo J. Valderrabano, Jie Zheng, J. Brent Richards, Eivind Coward, Claes Ohlsson","doi":"10.1038/s43587-024-00717-w","DOIUrl":"10.1038/s43587-024-00717-w","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00717-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rejuvenation of aged oocyte through exposure to young follicular microenvironment 暴露于年轻卵泡微环境中的高龄卵母细胞返老还童
IF 17
Nature aging Pub Date : 2024-09-09 DOI: 10.1038/s43587-024-00697-x
HaiYang Wang, Zhongwei Huang, Xingyu Shen, Yaelim Lee, XinJie Song, Chang Shu, Lik Hang Wu, Leroy Sivappiragasam Pakkiri, Poh Leong Lim, Xi Zhang, Chester Lee Drum, Jin Zhu, Rong Li
{"title":"Rejuvenation of aged oocyte through exposure to young follicular microenvironment","authors":"HaiYang Wang, Zhongwei Huang, Xingyu Shen, Yaelim Lee, XinJie Song, Chang Shu, Lik Hang Wu, Leroy Sivappiragasam Pakkiri, Poh Leong Lim, Xi Zhang, Chester Lee Drum, Jin Zhu, Rong Li","doi":"10.1038/s43587-024-00697-x","DOIUrl":"10.1038/s43587-024-00697-x","url":null,"abstract":"Reproductive aging is a major cause of fertility decline, attributed to decreased oocyte quantity and developmental potential. A possible cause is aging of the surrounding follicular somatic cells that support oocyte growth and development by providing nutrients and regulatory factors. Here, by creating chimeric follicles, whereby an oocyte from one follicle was transplanted into and cultured within another follicle whose native oocyte was removed, we show that young oocytes cultured in aged follicles exhibited impeded meiotic maturation and developmental potential, whereas aged oocytes cultured within young follicles were significantly improved in rates of maturation, blastocyst formation and live birth after in vitro fertilization and embryo implantation. This rejuvenation of aged oocytes was associated with enhanced interaction with somatic cells, transcriptomic and metabolomic remodeling, improved mitochondrial function and higher fidelity of meiotic chromosome segregation. These findings provide the basis for a future follicular somatic cell-based therapy to treat female infertility. Oocyte quality declines during aging. Here the authors show that oocytes from aged mice cultured within follicles from young mice have improved developmental potential. Aged oocytes cultured within young follicles have enhanced interaction with somatic cells, improved mitochondrial function and better meiotic chromosome segregation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142196159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stromal cell dysfunction contributes to thymic decline in aging 基质细胞功能障碍导致胸腺衰老。
IF 17
Nature aging Pub Date : 2024-09-06 DOI: 10.1038/s43587-024-00711-2
Hannah Walters
{"title":"Stromal cell dysfunction contributes to thymic decline in aging","authors":"Hannah Walters","doi":"10.1038/s43587-024-00711-2","DOIUrl":"10.1038/s43587-024-00711-2","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spermidine controls autophagy during fasting 精氨酸在禁食期间控制自噬。
IF 17
Nature aging Pub Date : 2024-09-04 DOI: 10.1038/s43587-024-00710-3
Anna Kriebs
{"title":"Spermidine controls autophagy during fasting","authors":"Anna Kriebs","doi":"10.1038/s43587-024-00710-3","DOIUrl":"10.1038/s43587-024-00710-3","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Older age reduces mtDNA mutation inheritance 年龄越大，mtDNA 变异的遗传性越低。
IF 17
Nature aging Pub Date : 2024-09-04 DOI: 10.1038/s43587-024-00701-4
Polyxeni Papadea, Nils-Göran Larsson
{"title":"Older age reduces mtDNA mutation inheritance","authors":"Polyxeni Papadea, Nils-Göran Larsson","doi":"10.1038/s43587-024-00701-4","DOIUrl":"10.1038/s43587-024-00701-4","url":null,"abstract":"A study from Ru, Deng, Chen, Zhang and colleagues investigates how mutations in the mitochondrial genes Nd1 and Nd5 are inherited in mice. The authors report that increased maternal age strengthens purifying selection during postnatal oocyte development, probably through an increase in oocyte protein synthesis.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA hydroxymethylation in aging 衰老过程中的 DNA 羟甲基化。
IF 17
Nature aging Pub Date : 2024-09-04 DOI: 10.1038/s43587-024-00709-w
George Andrew S. Inglis
{"title":"DNA hydroxymethylation in aging","authors":"George Andrew S. Inglis","doi":"10.1038/s43587-024-00709-w","DOIUrl":"10.1038/s43587-024-00709-w","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of coordination between basic cellular processes in human aging 人类衰老过程中基本细胞过程之间失去协调。
IF 17
Nature aging Pub Date : 2024-09-03 DOI: 10.1038/s43587-024-00696-y
Ana Carolina Leote, Francisco Lopes, Andreas Beyer
{"title":"Loss of coordination between basic cellular processes in human aging","authors":"Ana Carolina Leote, Francisco Lopes, Andreas Beyer","doi":"10.1038/s43587-024-00696-y","DOIUrl":"10.1038/s43587-024-00696-y","url":null,"abstract":"Age-related loss of gene expression coordination has been reported for distinct cell types and may lead to impaired cellular function. Here we propose a method for quantifying age-related changes in transcriptional regulatory relationships between genes, based on a model learned from external data. We used this method to uncover age-related trends in gene–gene relationships across eight human tissues, which demonstrates that reduced co-expression may also result from coordinated transcriptional responses. Our analyses reveal similar numbers of strengthening and weakening gene–gene relationships with age, impacting both tissue-specific (for example, coagulation in blood) and ubiquitous biological functions. Regulatory relationships becoming weaker with age were established mostly between genes operating in distinct cellular processes. As opposed to that, regulatory relationships becoming stronger with age were established both within and between different cellular functions. Our work reveals that, although most transcriptional regulatory gene–gene relationships are maintained during aging, those with declining regulatory coupling result mostly from a loss of coordination between distinct cellular processes. Age-related loss of gene expression coordination may contribute to impaired cellular function. In this study, the authors analyzed age-related trends in gene–gene relationships. They found that expression control often remains intact among genes involved in shared cellular functions while the coordination between functions tends to decline.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00696-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-associated changes in gene regulatory relationships affect basic cellular processes 与年龄相关的基因调控关系变化会影响基本的细胞过程。
IF 17
Nature aging Pub Date : 2024-09-03 DOI: 10.1038/s43587-024-00706-z
{"title":"Age-associated changes in gene regulatory relationships affect basic cellular processes","authors":"","doi":"10.1038/s43587-024-00706-z","DOIUrl":"10.1038/s43587-024-00706-z","url":null,"abstract":"We quantified age-related changes in gene regulatory relationships across eight human tissues. Our results reveal that the gene–gene relationships that become stronger with age affect mostly genes that operate on the same cellular processes, whereas relationships that become weaker affect genes involved in different processes.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging the epigenetic landscape in single cells to study aging trajectories 成像单细胞表观遗传景观，研究衰老轨迹。
IF 17
Nature aging Pub Date : 2024-08-29 DOI: 10.1038/s43587-024-00689-x
{"title":"Imaging the epigenetic landscape in single cells to study aging trajectories","authors":"","doi":"10.1038/s43587-024-00689-x","DOIUrl":"10.1038/s43587-024-00689-x","url":null,"abstract":"We developed ‘imaging-based chromatin and epigenetic age’ (ImAge), a technique that captures intrinsic age-related trajectories of the spatial organization of chromatin and epigenetic marks in single nuclei. We propose that ImAge represents a first-in-class imaging-based biomarker of aging with single-cell resolution.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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