Nature agingPub Date : 2025-02-19DOI: 10.1038/s43587-025-00813-5
Yun-Hee Youm, Christy Gliniak, Yuan Zhang, Tamara Dlugos, Philipp E Scherer, Vishwa Deep Dixit
{"title":"Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.","authors":"Yun-Hee Youm, Christy Gliniak, Yuan Zhang, Tamara Dlugos, Philipp E Scherer, Vishwa Deep Dixit","doi":"10.1038/s43587-025-00813-5","DOIUrl":"https://doi.org/10.1038/s43587-025-00813-5","url":null,"abstract":"<p><p>Age-related thymic involution precedes aging of all other organs in vertebrates and initiates the process of declining T cell diversity, which leads to eventual immune dysfunction. Whether FGF21, a liver-derived pro-longevity hormone that is also produced in thymic stroma, including by adipocytes, controls the mechanism of thymic demise is incompletely understood. Here, we demonstrate that elevation of FGF21 in thymic epithelial cells (TECs) and in adipocytes protects against thymic aging, whereas conditional hepatic overexpression did not impact thymic biology in aged mice. Notably, elevation of thymic FGF21 increased naïve CD8 T cells in aged animals and extended healthspan. Mechanistically, thymic FGF21 overexpression elevated TECs and reduced fibroadipogenic cells. Ablation of β-klotho, the obligatory co-receptor for FGF21 in Foxn1<sup>+</sup> TECs, accelerated thymic aging, suggesting regulation of TECs by FGF21 is partially required for thymic lymphopoiesis. These findings establish that paracrine FGF21 improves thymic function and delays immune aging.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-17DOI: 10.1038/s43587-025-00831-3
{"title":"Uncovering a gut microbiota-derived metabolite that triggers host cellular senescence","authors":"","doi":"10.1038/s43587-025-00831-3","DOIUrl":"10.1038/s43587-025-00831-3","url":null,"abstract":"During the healthy aging process, the microbial-derived metabolite phenylacetylglutamine (PAGln) drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via adrenoreceptor–AMPK signaling. Low-dose adrenoreceptor blockade treatment mitigates this PAGln-induced cellular senescence.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"346-347"},"PeriodicalIF":17.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-17DOI: 10.1038/s43587-025-00829-x
Daniel H. Nussey
{"title":"Studying aging in the wild can help us to understand resilience and healthy aging","authors":"Daniel H. Nussey","doi":"10.1038/s43587-025-00829-x","DOIUrl":"10.1038/s43587-025-00829-x","url":null,"abstract":"Environmental exposures contribute substantially to interindividual variation in aging outcomes, yet the range of exposures studied in the laboratory — or in relatively affluent human cohort studies — fails to capture the wide spectrum of challenges faced by human populations. Dan Nussey highlights how longitudinal studies of aging in the wild, such as the St Kilda Soay sheep project, can help us to understand variation in physiological resilience and healthy aging.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"337-338"},"PeriodicalIF":17.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-13DOI: 10.1038/s43587-025-00815-3
Jerome N. Feige
{"title":"An mTOR paradox in sarcopenia via BCAA catabolism","authors":"Jerome N. Feige","doi":"10.1038/s43587-025-00815-3","DOIUrl":"10.1038/s43587-025-00815-3","url":null,"abstract":"Dietary proteins stimulate skeletal muscle growth via mTOR-mediated activation of muscle protein synthesis by amino acids. Zuo and colleagues identify impaired mitochondrial branched-chain amino acid (BCAA) catabolism during sarcopenia. Pathological BCAA accumulation in aged muscle overactivates mTOR and paradoxically contributes to loss of muscle mass and strength by inhibiting autophagy and mitochondrial function.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"341-343"},"PeriodicalIF":17.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-12DOI: 10.1038/s43587-025-00810-8
Emelie Andersson, Nils Lindblom, Shorena Janelidze, Gemma Salvadó, Eleni Gkanatsiou, Linda Söderberg, Christer Möller, Lars Lannfelt, Junyue Ge, Jörg Hanrieder, Kaj Blennow, Tomas Deierborg, Niklas Mattsson-Carlgren, Henrik Zetterberg, Gunnar Gouras, Oskar Hansson
{"title":"Soluble cerebral Aβ protofibrils link Aβ plaque pathology to changes in CSF Aβ42/Aβ40 ratios, neurofilament light and tau in Alzheimer’s disease model mice","authors":"Emelie Andersson, Nils Lindblom, Shorena Janelidze, Gemma Salvadó, Eleni Gkanatsiou, Linda Söderberg, Christer Möller, Lars Lannfelt, Junyue Ge, Jörg Hanrieder, Kaj Blennow, Tomas Deierborg, Niklas Mattsson-Carlgren, Henrik Zetterberg, Gunnar Gouras, Oskar Hansson","doi":"10.1038/s43587-025-00810-8","DOIUrl":"10.1038/s43587-025-00810-8","url":null,"abstract":"The Aβ42/Aβ40 ratio in the cerebrospinal fluid (CSF) and the concentrations of neurofilament light (NfL) and total tau (t-tau) are changed in the early stages of Alzheimer’s disease (AD)1, but their neurobiological correlates are not entirely understood. Here, we used 5xFAD transgenic mice to investigate the associations between these CSF biomarkers and measures of cerebral Aβ, including Aβ42/Aβ40 ratios in plaques, insoluble fibrillar deposits and soluble protofibrils. A high Aβ42/Aβ40 ratio in soluble protofibrils was the strongest independent predictor of low CSF Aβ42/Aβ40 ratios and high CSF NfL and t-tau concentrations when compared to Aβ42/Aβ40 ratios in plaques and insoluble fibrillar deposits. Furthermore, the Aβ42/Aβ40 ratio in soluble protofibrils fully mediated the associations between the corresponding ratio in plaques and all the investigated CSF biomarkers. In AppNL-G-F/NL-G-F knock-in mice, protofibrils fully mediated the association between plaques and the CSF Aβ42/Aβ40 ratio. Together, the results suggest that the Aβ42/Aβ40 ratio in CSF might better reflect brain levels of soluble Aβ protofibrils than insoluble Aβ fibrils in plaques in AD. Furthermore, elevated concentrations of NfL and t-tau in CSF might be triggered by increased brain levels of soluble Aβ protofibrils. Andersson et al. identify that high Aβ42/Aβ40 ratios in brain protofibrils best predict lower Aβ42/Aβ40 ratios in the cerebrospinal fluid (CSF) and higher neurofilament light/total tau levels, indicating that CSF changes in Alzheimer’s disease reflect soluble protofibrils more accurately than amyloid plaques.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"366-375"},"PeriodicalIF":17.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-025-00810-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-12DOI: 10.1038/s43587-025-00826-0
George Andrew S. Inglis
{"title":"Oligodendrocyte ankyrin G in aging","authors":"George Andrew S. Inglis","doi":"10.1038/s43587-025-00826-0","DOIUrl":"10.1038/s43587-025-00826-0","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"178-178"},"PeriodicalIF":17.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-10DOI: 10.1038/s43587-025-00825-1
Yahyah Aman
{"title":"Effect of cholinergic modulator in Parkinson’s disease with cognitive impairment","authors":"Yahyah Aman","doi":"10.1038/s43587-025-00825-1","DOIUrl":"10.1038/s43587-025-00825-1","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"177-177"},"PeriodicalIF":17.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-06DOI: 10.1038/s43587-025-00812-6
Toshiko Tanaka, Felipe Sierra, Vadim N. Gladyshev, Tony Wyss-Coray, Ana Maria Cuervo, Viviana Perez, Luigi Ferrucci, On behalf of the Hevolution Alliance for Aging Biomarkers
{"title":"Recommendations for implementing the Hevolution Alliance for Aging Biomarkers initiative","authors":"Toshiko Tanaka, Felipe Sierra, Vadim N. Gladyshev, Tony Wyss-Coray, Ana Maria Cuervo, Viviana Perez, Luigi Ferrucci, On behalf of the Hevolution Alliance for Aging Biomarkers","doi":"10.1038/s43587-025-00812-6","DOIUrl":"10.1038/s43587-025-00812-6","url":null,"abstract":"In January 2024, a Hevolution Alliance for Aging Biomarkers thinktank convened at Cold Spring Harbor to discuss the framework for creating an open and diverse data resource for developing reliable aging biomarkers. As the funding for this initiative has now been confirmed, we summarize recommendations and key milestones for its implementation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"188-192"},"PeriodicalIF":17.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-05DOI: 10.1038/s43587-025-00821-5
{"title":"Multiomics atlas reveals molecular and genetic drivers of human ovarian aging","authors":"","doi":"10.1038/s43587-025-00821-5","DOIUrl":"10.1038/s43587-025-00821-5","url":null,"abstract":"Single-nuclei multiomics analyses of ovarian tissue from young and reproductively aged individuals reveal mTOR signaling as an ovary-specific aging pathway and identify functional genetic variants associated with ovarian aging. This comprehensive atlas provides insights into molecular and genetic mechanisms of ovarian aging and potential therapeutic targets for reproductive longevity.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"186-187"},"PeriodicalIF":17.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature agingPub Date : 2025-02-05DOI: 10.1038/s43587-025-00822-4
{"title":"Transdisciplinary links between societal inequality and brain structure and dynamics","authors":"","doi":"10.1038/s43587-025-00822-4","DOIUrl":"10.1038/s43587-025-00822-4","url":null,"abstract":"This study highlights the biological embedding of aggregate-level structural socioeconomic inequality and reveals its effect on brain volume and network dynamics, particularly in aging, Alzheimer’s disease and frontotemporal dementia. Through a comparative analysis between Latin America and the USA, the research highlights brain health disparities driven by structural inequality.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"184-185"},"PeriodicalIF":17.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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