Nature aging最新文献_第5页

The CALERIE Genomic Data Resource. CALERIE 基因组数据资源。

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Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00775-0

C P Ryan, D L Corcoran, N Banskota, C Eckstein Indik, A Floratos, R Friedman, M S Kobor, V B Kraus, W E Kraus, J L MacIsaac, M C Orenduff, C F Pieper, J P White, L Ferrucci, S Horvath, K M Huffman, D W Belsky

{"title":"The CALERIE Genomic Data Resource.","authors":"C P Ryan, D L Corcoran, N Banskota, C Eckstein Indik, A Floratos, R Friedman, M S Kobor, V B Kraus, W E Kraus, J L MacIsaac, M C Orenduff, C F Pieper, J P White, L Ferrucci, S Horvath, K M Huffman, D W Belsky","doi":"10.1038/s43587-024-00775-0","DOIUrl":"10.1038/s43587-024-00775-0","url":null,"abstract":"Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 .","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hallmarks of female reproductive aging in physiologic aging mice 生理衰老小鼠雌性生殖衰老的特征

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00769-y

Julia L. Balough, Shweta S. Dipali, Karen Velez, T. Rajendra Kumar, Francesca E. Duncan

{"title":"Hallmarks of female reproductive aging in physiologic aging mice","authors":"Julia L. Balough, Shweta S. Dipali, Karen Velez, T. Rajendra Kumar, Francesca E. Duncan","doi":"10.1038/s43587-024-00769-y","DOIUrl":"10.1038/s43587-024-00769-y","url":null,"abstract":"The female reproductive axis is one of the first organ systems to age, which has consequences for fertility and overall health. Here, we provide a comprehensive overview of the biological process of female reproductive aging across reproductive organs, tissues and cells based on research with widely used physiologic aging mouse models, and describe the mechanisms that underpin these phenotypes. Overall, aging is associated with dysregulation of the hypothalamic–pituitary–ovarian axis, perturbations of the ovarian stroma, reduced egg quantity and quality, and altered uterine morphology and function that contributes to reduced capacity for fertilization and impaired embryo development. Ultimately, these age-related phenotypes contribute to altered pregnancy outcomes and adverse consequences in offspring. Conserved mechanisms of aging, as well as those unique to the reproductive system, underlie these phenotypes. The knowledge of such mechanisms will lead to development of therapeutics to extend female reproductive longevity and support endocrine function and overall health. Female reproductive system aging has consequences for fertility and overall health. In this Review, the authors provide a comprehensive overview of the biological process of female reproductive aging based on research with physiologic aging mouse models, and describe the mechanisms that underlie these phenotypes.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1711-1730"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause 探讨雌激素缺乏和衰老对绝经期机体稳态的影响

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00767-0

Celine Camon, Michael Garratt, Stephanie M. Correa

{"title":"Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause","authors":"Celine Camon, Michael Garratt, Stephanie M. Correa","doi":"10.1038/s43587-024-00767-0","DOIUrl":"10.1038/s43587-024-00767-0","url":null,"abstract":"Sex hormone signaling declines during aging, from early midlife through menopause, as a consequence of reduced circulating estrogens and decreased receptiveness to these hormones in target tissues. Estrogens preserve energy homeostasis and promote metabolic health via coordinated and simultaneous effects throughout the brain and body. Age-associated loss of estrogen production during menopause has been implicated in a higher risk for metabolic diseases and increased mortality. However, it remains unclear whether age-associated changes in homeostasis are dependent on reduced estrogen signaling during menopause. Although menopausal hormone therapies containing estrogens can alleviate symptoms, concerns about the risks involved have contributed to a broad decline in the use of these approaches. Non-hormonal therapies have emerged that target tissues or pathways with varying levels of selectivity, reducing risk. We summarize here the broad effects of estrogen loss on homeostasis during menopause, current and emerging therapies and opportunities for understanding homeostatic disruptions associated with menopause. Sex hormone signaling declines during aging. In this Review, the authors provide an overview of the role of estrogen signaling in the maintenance of energy homeostasis and the dysregulation of this equilibrium during menopause, dissect the contributions of hormonal decline and aging to health changes and discuss current and emerging therapies.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1731-1744"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on biomarkers of reproductive aging for fertility and beyond 生殖老化生物标志物对生育及其他问题的展望

IF 17

Nature aging Pub Date : 2024-12-13 DOI: 10.1038/s43587-024-00770-5

Si Wang, Jie Ren, Ying Jing, Jing Qu, Guang-Hui Liu

{"title":"Perspectives on biomarkers of reproductive aging for fertility and beyond","authors":"Si Wang, Jie Ren, Ying Jing, Jing Qu, Guang-Hui Liu","doi":"10.1038/s43587-024-00770-5","DOIUrl":"10.1038/s43587-024-00770-5","url":null,"abstract":"Reproductive aging, spanning an age-related functional decline in the female and male reproductive systems, compromises fertility and leads to a range of health complications. In this Perspective, we first introduce a comprehensive framework for biomarkers applicable in clinical settings and discuss the existing repertoire of biomarkers used in practice. These encompass functional, imaging-based and biofluid-based biomarkers, all of which reflect the physiological characteristics of reproductive aging and help to determine the reproductive biological age. Next, we delve into the molecular alterations associated with aging in the reproductive system, highlighting the gap between these changes and their potential as biomarkers. Finally, to enhance the precision and practicality of assessing reproductive aging, we suggest adopting cutting-edge technologies for identifying new biomarkers and conducting thorough validations in population studies before clinical applications. These advancements will foster improved comprehension, prognosis and treatment of subfertility, thereby increasing chances of preserving reproductive health and resilience in populations of advanced age. Measuring reproductive aging in humans remains challenging. In this Perspective, Wang et al. summarize biomarkers for reproductive aging in clinical use, discuss age-linked molecular changes related to reproductive aging that could potentially serve as future biomarkers and highlight unresolved challenges and upcoming opportunities in the field.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1697-1710"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges for aging research in Lebanon in times of crisis and conflict 危机和冲突时期黎巴嫩老龄化研究面临的挑战。

IF 17

Nature aging Pub Date : 2024-12-10 DOI: 10.1038/s43587-024-00787-w

Martine Elbejjani, Adina Zeki Al Hazzouri, Kaylie Moropoulos, Abla M. Sibai

引用次数: 0

IL-23R is a senescence-linked circulating and tissue biomarker of aging. IL-23R是一种与衰老相关的循环和组织生物标志物。

IF 17

Nature aging Pub Date : 2024-12-10 DOI: 10.1038/s43587-024-00752-7

Chase M Carver, Sonia L Rodriguez, Elizabeth J Atkinson, Andrew J Dosch, Niels C Asmussen, Paul T Gomez, Ethan A Leitschuh, Jair M Espindola-Netto, Karthik B Jeganathan, Madison G Whaley, Theodore M Kamenecka, Darren J Baker, Andrew J Haak, Nathan K LeBrasseur, Marissa J Schafer

{"title":"IL-23R is a senescence-linked circulating and tissue biomarker of aging.","authors":"Chase M Carver, Sonia L Rodriguez, Elizabeth J Atkinson, Andrew J Dosch, Niels C Asmussen, Paul T Gomez, Ethan A Leitschuh, Jair M Espindola-Netto, Karthik B Jeganathan, Madison G Whaley, Theodore M Kamenecka, Darren J Baker, Andrew J Haak, Nathan K LeBrasseur, Marissa J Schafer","doi":"10.1038/s43587-024-00752-7","DOIUrl":"10.1038/s43587-024-00752-7","url":null,"abstract":"Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells, can counteract age-associated conditions that span several organs. The comparative efficacy of distinct senolytic drugs for modifying aging and senescence biomarkers in vivo has not been demonstrated. Here, we established aging- and senescence-related plasma proteins and tissue transcripts that changed in old versus young female and male mice. We investigated responsivity to acute treatment with venetoclax, navitoclax, fisetin or luteolin versus transgenic senescent cell clearance in aged p16-InkAttac mice. We discovered that age-dependent changes in plasma proteins, including IL-23R, CCL5 and CA13, were reversed by senotherapeutics, which corresponded to expression differences in tissues, particularly in the kidney. In plasma from humans across the lifespan, IL-23R increased with age. Our results reveal circulating factors as candidate mediators of senescence-associated interorgan signal transduction and translationally impactful biomarkers of systemic senescent cell burden.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma proteomics identify biomarkers and undulating changes of brain aging 血浆蛋白质组学确定了大脑衰老的生物标志物和起伏变化。

IF 17

Nature aging Pub Date : 2024-12-09 DOI: 10.1038/s43587-024-00753-6

Wei-Shi Liu, Jia You, Shi-Dong Chen, Yi Zhang, Jian-Feng Feng, Yu-Ming Xu, Jin-Tai Yu, Wei Cheng

{"title":"Plasma proteomics identify biomarkers and undulating changes of brain aging","authors":"Wei-Shi Liu, Jia You, Shi-Dong Chen, Yi Zhang, Jian-Feng Feng, Yu-Ming Xu, Jin-Tai Yu, Wei Cheng","doi":"10.1038/s43587-024-00753-6","DOIUrl":"10.1038/s43587-024-00753-6","url":null,"abstract":"Proteomics enables the characterization of brain aging biomarkers and discernment of changes during brain aging. We leveraged multimodal brain imaging data from 10,949 healthy adults to estimate brain age gap (BAG), an indicator of brain aging. Proteome-wide association analysis across 4,696 participants of 2,922 proteins identified 13 significantly associated with BAG, implicating stress, regeneration and inflammation. Brevican (BCAN) (β = −0.838, P = 2.63 × 10−10) and growth differentiation factor 15 (β = 0.825, P = 3.48 × 10−11) showed the most significant, and multiple, associations with dementia, stroke and movement functions. Dysregulation of BCAN affected multiple cortical and subcortical structures. Mendelian randomization supported the causal association between BCAN and BAG. We revealed undulating changes in the plasma proteome across brain aging, and profiled brain age-related change peaks at 57, 70 and 78 years, implicating distinct biological pathways during brain aging. Our findings revealed the plasma proteomic landscape of brain aging and pinpointed biomarkers for brain disorders. Using proteomics and imaging data from UK Biobank, the authors identified multiple circulating proteins associated with brain aging and discovered undulating age-related changes in the plasma proteome, with peaks occurring at 57, 70 and 78 years of age.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"99-112"},"PeriodicalIF":17.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions. 绘制老年人大脑中的microRNA景观及其对神经精神疾病的遗传贡献。

IF 17

Nature aging Pub Date : 2024-12-06 DOI: 10.1038/s43587-024-00778-x

Selina M Vattathil, Ekaterina S Gerasimov, Se Min Canon, Adriana Lori, Sarah Sze Min Tan, Paul J Kim, Yue Liu, Eric C Lai, David A Bennett, Thomas S Wingo, Aliza P Wingo

{"title":"Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions.","authors":"Selina M Vattathil, Ekaterina S Gerasimov, Se Min Canon, Adriana Lori, Sarah Sze Min Tan, Paul J Kim, Yue Liu, Eric C Lai, David A Bennett, Thomas S Wingo, Aliza P Wingo","doi":"10.1038/s43587-024-00778-x","DOIUrl":"10.1038/s43587-024-00778-x","url":null,"abstract":"MicroRNAs (miRNAs) play a crucial role in regulating gene expression and influence many biological processes. Despite their importance, understanding of how genetic variation affects miRNA expression in the brain and how this relates to brain disorders remains limited. Here we investigated these questions by identifying microRNA expression quantitative trait loci (miR-QTLs), or genetic variants associated with brain miRNA levels, using genome-wide small RNA sequencing profiles from dorsolateral prefrontal cortex samples of 604 older adult donors of European ancestry. Here we show that nearly half (224 of 470) of the analyzed miRNAs have associated miR-QTLs, many of which fall in regulatory regions such as brain promoters and enhancers. We also demonstrate that intragenic miRNAs often have genetic regulation independent from their host genes. Furthermore, by integrating our findings with 16 genome-wide association studies of psychiatric and neurodegenerative disorders, we identified miRNAs that likely contribute to bipolar disorder, depression, schizophrenia and Parkinson's disease. These findings advance understanding of the genetic regulation of miRNAs and their role in brain health and disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":""},"PeriodicalIF":17.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-related changes in mammary gland increase tumorigenesis 年龄相关的乳腺变化会增加肿瘤的发生。

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Nature aging Pub Date : 2024-12-05 DOI: 10.1038/s43587-024-00783-0

Anna Kriebs

引用次数: 0

Age as an ingredient of household food waste 年龄是家庭食物垃圾的一个组成部分。

IF 17

Nature aging Pub Date : 2024-12-04 DOI: 10.1038/s43587-024-00784-z

George Andrew S. Inglis

引用次数: 0