A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions.

IF 17 Q1 CELL BIOLOGY
Nature aging Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI:10.1038/s43587-025-00886-2
Jing Wang, Xiaolan Zhou, Peng Yu, Jun Yao, Pengfei Guo, Qiushi Xu, Yuqi Zhao, Guanlong Wang, Qianru Li, Xiaofeng Zhu, Gang Wei, Weixu Wang, Ting Ni
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引用次数: 0

Abstract

Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited markers or homogeneous samples, which might fail to capture universal senescence features, limiting their generalizability. Here we developed the human universal senescence index (hUSI), an accurate and robust senescence evaluation method for diverse cells and samples. Based on features learned from the most comprehensive cellular senescence-associated transcriptome data so far, hUSI demonstrated its convincing connections with senescence phenotypes and superior robustness in predicting senescence state. Using hUSI, we discovered potential senescence regulators and mapped senescent cell accumulation across cell types in coronavirus disease 2019 (COVID-19). The method also facilitates decoding heterogeneous senescence states in melanoma tumors, identifying prognosis-associated signaling pathways. Overall, hUSI demonstrates its utility in characterizing cellular senescence across biological contexts, with broad applications in aging research and clinical practice.

基于转录组的人类普遍衰老指数(hUSI)在各种条件下可靠地预测细胞衰老。
尽管细胞衰老在衰老和各种疾病中的表现和贡献,但准确识别异质性衰老细胞仍然具有挑战性。目前的衰老评估方法主要依赖于有限的标记物或同质样本,可能无法捕捉到普遍的衰老特征,限制了其通用性。我们建立了人类普遍衰老指数(hUSI),这是一种针对不同细胞和样本的准确、稳健的衰老评估方法。基于迄今为止从最全面的细胞衰老相关转录组数据中了解到的特征,hUSI证明了其与衰老表型的令人信服的联系以及在预测衰老状态方面的优越稳健性。利用hUSI,我们发现了潜在的衰老调节因子,并绘制了2019冠状病毒病(COVID-19)中不同细胞类型的衰老细胞积累图谱。该方法还有助于解码黑色素瘤肿瘤的异质衰老状态,识别预后相关的信号通路。总体而言,hUSI证明了其在生物学背景下表征细胞衰老的效用,在衰老研究和临床实践中具有广泛的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
14.70
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0.00%
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