Nature aging最新文献

{"title":"Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas","authors":"Agustina Legaz, Florencia Altschuler, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Vicente Medel, Marcelo Adrián Maito, María E. Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazuchi, Hernando Santamaria Garcia, Francesca R. Farina, Pablo Reyes, Shireen Javandel, Adolfo M. García, Álvaro Deleglise, Diana L. Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I. Behrens, Nilton Custodio, Catalina Trujillo-Llano, Juan F. Cardona, Pablo Barttfeld, Ignacio L. Brusco, Martín A. Bruno, Ana L. Sosa Ortiz, Stefanie D. Pina-Escudero, Leonel T. Takada, Elisa de Paula França Resende, Katherine L. Possin, Maira Okada de Oliveira, Kun Hu, Francisco Lopera, Brian Lawlor, Victor Valcour, Jennifer S. Yokoyama, Bruce Miller, Agustin Ibañez","doi":"10.1038/s43587-024-00781-2","DOIUrl":"10.1038/s43587-024-00781-2","url":null,"abstract":"Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations. The authors find that structural economic inequality is linked to reduced brain volume and connectivity in middle-aged and older adults across the Americas, more so in Alzheimer’s disease than in frontotemporal dementia. The findings emphasize the biological embedding of inequality in aging and dementia.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"259-274"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global analysis of adaptation to societal aging across low-, middle- and high-income countries using the Global Aging Society Index","authors":"Cynthia Chen, Julian Lim, Jemima Koh, John Beard, John W. Rowe, for the Research Network on an Aging Society","doi":"10.1038/s43587-024-00772-3","DOIUrl":"10.1038/s43587-024-00772-3","url":null,"abstract":"We have previously presented a multidimensional Aging Society Index, a weighted summation of five domains central to successful adaptation to societal aging: well-being, productivity and engagement, equity, cohesion and security, as a tool to assess countries’ adaptation to demographic transformation. As the index was based on data from developed countries and some of the individual metrics or weightings may not be well suited for application to low- and middle-income countries, we here present the scores on a modified index (Global Aging Society Index) on 143 countries distributed across the span of economic development. Only 5 out of 143 (3.5%) countries had higher scores for women than men. Countries with the most notable gender differences were primarily low-income countries. The multidimensional index permits cross-national comparisons and may facilitate the identification of targets for developing policies and programs to enhance the likelihood that older persons will age successfully. The authors score and rank the adaptation to societal aging across 143 countries using a newly developed index called the Global Aging Society Index, which may be helpful to identify targets for the development of policies and programs to enhance the likelihood that older people will age successfully.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"113-121"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00772-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort trends in intrinsic capacity in England and China","authors":"John R. Beard, Katja Hanewald, Yafei Si, Jotheeswaran Amuthavalli Thiyagarajan, Dario Moreno-Agostino","doi":"10.1038/s43587-024-00741-w","DOIUrl":"10.1038/s43587-024-00741-w","url":null,"abstract":"To understand how the health of older adults today compares to that of previous generations, we estimated intrinsic capacity and subdomains of cognitive, locomotor, sensory, psychological and vitality capacities in participants of the English Longitudinal Study of Ageing and the China Health and Retirement Longitudinal Study. Applying multilevel growth curve models, we found that more recent cohorts entered older ages with higher levels of capacity, while subsequent age-related declines were somewhat compressed compared to earlier cohorts. Trends were most evident for the cognitive, locomotor and vitality capacities. Improvements were large, with the greatest gains being in the most recent cohorts. For example, a 68-year-old participant of the English Longitudinal Study of Ageing born in 1950 had higher capacity than a 62-year-old born 10 years earlier. Trends were similar for men and women and were generally consistent across English and Chinese cohorts. Possible causes include broad societal influences and improvements in medical care. Intrinsic capacity includes a person’s mental and physical capacities. The authors examined cohort trends in intrinsic capacity in two large English and Chinese studies. They report that more recently born participants entered older ages with markedly higher levels of functioning, while subsequent age-related declines were somewhat delayed.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"87-98"},"PeriodicalIF":17.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00741-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting the sexual healthcare needs of aging women","authors":"Holly N. Thomas","doi":"10.1038/s43587-024-00725-w","DOIUrl":"10.1038/s43587-024-00725-w","url":null,"abstract":"A satisfying sex life is a key component of health and well-being for many older women. However, there is insufficient awareness of and care for women’s sexual health. This Comment discusses steps healthcare providers can take to support women’s sexual health across the lifespan, which should be a top priority.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1660-1662"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging therapeutic strategies to mitigate female and male reproductive aging","authors":"Yasmyn E. Winstanley, Jennifer S. Stables, Macarena B. Gonzalez, Takashi Umehara, Robert J. Norman, Rebecca L. Robker","doi":"10.1038/s43587-024-00771-4","DOIUrl":"10.1038/s43587-024-00771-4","url":null,"abstract":"People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development. Preclinical studies, in mouse models of aging, have identified pharmaceutical candidates that improve egg and sperm quality. Further, a diverse array of medically assisted reproduction methodologies, including those that stimulate rare ovarian follicles and rejuvenate egg quality using mitochondria, may have future utility for older patients. Finally, we highlight the many knowledge gaps and possible future directions in the field of therapeutics to extend the age of healthy human reproduction. People now choose to start families in their 30s to 40s, when fertility is low owing to reproductive aging. In this Perspective, the authors highlight the absence of clinically confirmed therapeutics to mitigate reproductive aging or extend fertility, and they summarize the range of emerging strategies and point to knowledge gaps and future directions in the field.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1682-1696"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy longevity requires bridging reproductive medicine, aging research and public engagement","authors":"Zhongwei Huang, on behalf of NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE)","doi":"10.1038/s43587-024-00713-0","DOIUrl":"10.1038/s43587-024-00713-0","url":null,"abstract":"Reproductive health is fundamentally connected with overall health. The Bia-Echo Asia Centre for Reproductive Longevity and Equality discusses an innovative approach to healthy longevity that is tailored uniquely to individual patterns of aging, which will require reproductive medicine, biological aging research and public engagement to join forces.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1658-1659"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy aging in individuals born after assisted reproductive technology is a research area for the future","authors":"Anna Sophie Lebech Kjaer, Maria Linander Vestager, Rikke Beck Jensen, Anja Pinborg","doi":"10.1038/s43587-024-00721-0","DOIUrl":"10.1038/s43587-024-00721-0","url":null,"abstract":"As fertility rates decline and childbearing age increases globally, assisted reproductive technology (ART) has a crucial role in enhancing birth rates and will contribute substantially to future generations. ART has fulfilled family formation wishes for many individuals facing infertility and aids in solving demographic challenges. Today, up to 9% of the European population is conceived after ART. Considerable advancements in ARTs have improved the effectiveness of treatment, but the ultimate quality control in ART is healthy offspring. Therefore, it is of utmost importance to monitor the health of individuals conceived through ART, and ensure that ART not only provides for the birth of healthy children but also for health into old age.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1663-1666"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive aging research as a gateway to health and wellbeing","authors":"","doi":"10.1038/s43587-024-00786-x","DOIUrl":"10.1038/s43587-024-00786-x","url":null,"abstract":"Reproductive aging is increasingly recognized as an important determinant of fertility span and overall health and wellbeing in older age. In this Focus issue, Nature Aging presents a series of reviews and opinion pieces on recent advances in reproductive aging research.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1657-1657"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00786-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CALERIE Genomic Data Resource","authors":"C. P. Ryan, D. L. Corcoran, N. Banskota, C. Eckstein Indik, A. Floratos, R. Friedman, M. S. Kobor, V. B. Kraus, W. E. Kraus, J. L. MacIsaac, M. C. Orenduff, C. F. Pieper, J. P. White, L. Ferrucci, S. Horvath, K. M. Huffman, D. W. Belsky","doi":"10.1038/s43587-024-00775-0","DOIUrl":"10.1038/s43587-024-00775-0","url":null,"abstract":"Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial. These data constitute a genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome single-nucleotide polymorphism genotypes, and three-timepoint-longitudinal DNA methylation, mRNA and small RNA datasets generated from blood, skeletal muscle and adipose tissue samples (total sample n = 2,327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omics, longitudinal data resource has great potential to advance translational geroscience. ClinicalTrials.gov registration: NCT00427193 . Ryan and colleagues present multi-tissue, multi-omics, longitudinal datasets from the CALERIE phase 2 randomized controlled trial of caloric restriction in humans, providing a powerful resource for translational geroscience.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"320-331"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring","authors":"Stefania Benonisdottir, Vincent J. Straub, Augustine Kong, Melinda C. Mills","doi":"10.1038/s43587-024-00733-w","DOIUrl":"10.1038/s43587-024-00733-w","url":null,"abstract":"Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increasingly important. Although monogenic genetic effects are known, the genetics underlying human reproductive traits are complex, with both causal effects and statistical bias often confounded by socioeconomic factors. Here, we review genome-wide association studies (GWASs) of 44 reproductive traits of both female and male individuals from 2007 to early 2024, examining reproductive behavior, reproductive lifespan and aging, infertility and hormonal concentration. Using the GWAS Catalog as a basis, from 159 relevant studies, we isolate 37 genes that harbor association signals for four or more reproductive traits, more than half of which are linked to rare Mendelian disorders, including ten genes linked to reproductive-related disorders: FSHB, MCM8, DNAH2, WNT4, ESR1, IGSF1, THRB, BRWD1, CYP19A1 and PTPRF. We also review the relationship of reproductive genetics to related health and behavioral traits, aging and longevity and the effect of parental age on offspring outcomes as well as reflecting on limitations, open questions and challenges in this fast-moving field. Benonisdottir et al. review the genetics of reproductive traits and examine how these associate with links to health, behavior, aging and longevity as well as outcomes for offspring.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"4 12","pages":"1745-1759"},"PeriodicalIF":17.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}