Nature aging最新文献

筛选
英文 中文
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells. 作者更正:源于龛位的Semaphorin 4A可保护髓系偏异造血干细胞的功能特性。
IF 17
Nature aging Pub Date : 2025-04-01 DOI: 10.1038/s43587-025-00837-x
Dorsa Toghani, Sanika Gupte, Sharon Zeng, Elmir Mahammadov, Edie I Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Alexis Georgiades, Fabienne Lucas, Nicola K Wilson, Sarah J Kinston, Berthold Göttgens, Le Zong, Isabel Beerman, Bongsoo Park, Derek H Janssens, Daniel Jones, Ali Toghani, Claus Nerlov, Eric M Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Jin-Gyu Cheong, Steven Z Josefowicz, Peter Kharchenko, David T Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein
{"title":"Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.","authors":"Dorsa Toghani, Sanika Gupte, Sharon Zeng, Elmir Mahammadov, Edie I Crosse, Negar Seyedhassantehrani, Christian Burns, David Gravano, Stefan Radtke, Hans-Peter Kiem, Sonia Rodriguez, Nadia Carlesso, Amogh Pradeep, Alexis Georgiades, Fabienne Lucas, Nicola K Wilson, Sarah J Kinston, Berthold Göttgens, Le Zong, Isabel Beerman, Bongsoo Park, Derek H Janssens, Daniel Jones, Ali Toghani, Claus Nerlov, Eric M Pietras, Marion Mesnieres, Christa Maes, Atsushi Kumanogoh, Thomas Worzfeld, Jin-Gyu Cheong, Steven Z Josefowicz, Peter Kharchenko, David T Scadden, Antonio Scialdone, Joel A Spencer, Lev Silberstein","doi":"10.1038/s43587-025-00837-x","DOIUrl":"10.1038/s43587-025-00837-x","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"720"},"PeriodicalIF":17.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invigorating discovery and clinical translation of aging biomarkers. 促进衰老生物标志物的发现和临床转化。
IF 17
Nature aging Pub Date : 2025-04-01 DOI: 10.1038/s43587-025-00838-w
Erik Jacques, Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, Raghav Sehgal, Seth Paulson, Julian Reinhard, Jakob Träuble, Waylon J Hastings, Alexander Tyshkovskiy, Sara Hägg, John C Earls, Christian E Behrens, Jessica Lasky-Su, Gavin Zhou, Eric Morgen, John S Tsang, Riccardo E Marioni, Xiao-Jun Ma, Alexandra Stolzing, Christin Glorioso, Jonathan S Gootenberg, Omar O Abudayyeh, M Austin Argentieri, Raymond H Mak, Lynne S Cox, Andrew S Brack, Gordan Lauc, David Furman, Jason D Buenrostro, Björn Schumacher, Jamie N Justice, Tina Woods, David Gobel, Viviana I Perez, David A Sinclair, Andrea B Maier, Nir Barzilai, Michael P Snyder, Tony Wyss-Coray, Steve Horvath, Luigi Ferrucci, Jesse R Poganik, Mahdi Moqri, Vadim N Gladyshev
{"title":"Invigorating discovery and clinical translation of aging biomarkers.","authors":"Erik Jacques, Chiara Herzog, Kejun Ying, Alan Tomusiak, Jessica Kasamoto, Raghav Sehgal, Seth Paulson, Julian Reinhard, Jakob Träuble, Waylon J Hastings, Alexander Tyshkovskiy, Sara Hägg, John C Earls, Christian E Behrens, Jessica Lasky-Su, Gavin Zhou, Eric Morgen, John S Tsang, Riccardo E Marioni, Xiao-Jun Ma, Alexandra Stolzing, Christin Glorioso, Jonathan S Gootenberg, Omar O Abudayyeh, M Austin Argentieri, Raymond H Mak, Lynne S Cox, Andrew S Brack, Gordan Lauc, David Furman, Jason D Buenrostro, Björn Schumacher, Jamie N Justice, Tina Woods, David Gobel, Viviana I Perez, David A Sinclair, Andrea B Maier, Nir Barzilai, Michael P Snyder, Tony Wyss-Coray, Steve Horvath, Luigi Ferrucci, Jesse R Poganik, Mahdi Moqri, Vadim N Gladyshev","doi":"10.1038/s43587-025-00838-w","DOIUrl":"10.1038/s43587-025-00838-w","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"539-543"},"PeriodicalIF":17.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Women In Autophagy network empowers global equity in science. 自噬中的女性网络促进了科学领域的全球平等。
IF 17
Nature aging Pub Date : 2025-04-01 DOI: 10.1038/s43587-025-00839-9
Ghita Ghislat, Inmaculada Tasset
{"title":"The Women In Autophagy network empowers global equity in science.","authors":"Ghita Ghislat, Inmaculada Tasset","doi":"10.1038/s43587-025-00839-9","DOIUrl":"10.1038/s43587-025-00839-9","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"532-533"},"PeriodicalIF":17.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging. 性别特异性和细胞类型特异性变化的伴侣介导的自噬跨组织在衰老过程中。
IF 17
Nature aging Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1038/s43587-024-00799-6
Rabia R Khawaja, Adrián Martín-Segura, Olaya Santiago-Fernández, Rebecca Sereda, Kristen Lindenau, Mericka McCabe, Adrián Macho-González, Maryam Jafari, Aurora Scrivo, Raquel Gomez-Sintes, Bhakti Chavda, Ana Rosa Saez-Ibanez, Inmaculada Tasset, Esperanza Arias, Xianhong Xie, Mimi Kim, Susmita Kaushik, Ana Maria Cuervo
{"title":"Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging.","authors":"Rabia R Khawaja, Adrián Martín-Segura, Olaya Santiago-Fernández, Rebecca Sereda, Kristen Lindenau, Mericka McCabe, Adrián Macho-González, Maryam Jafari, Aurora Scrivo, Raquel Gomez-Sintes, Bhakti Chavda, Ana Rosa Saez-Ibanez, Inmaculada Tasset, Esperanza Arias, Xianhong Xie, Mimi Kim, Susmita Kaushik, Ana Maria Cuervo","doi":"10.1038/s43587-024-00799-6","DOIUrl":"10.1038/s43587-024-00799-6","url":null,"abstract":"<p><p>Aging leads to progressive decline in organ and tissue integrity and function, partly due to loss of proteostasis and autophagy malfunctioning. A decrease with age in chaperone-mediated autophagy (CMA), a selective type of lysosomal degradation, has been reported in various organs and cells from rodents and humans. Disruption of CMA recapitulates features of aging, whereas activating CMA in mice protects against age-related diseases such as Alzheimer's, retinal degeneration and/or atherosclerosis. However, sex-specific and cell-type-specific differences in CMA with aging remain unexplored. Here, using CMA reporter mice and single-cell transcriptomic data, we report that most organs and cell types show CMA decline with age, with males exhibiting a greater decline with aging. Reduced CMA is often associated with fewer lysosomes competent for CMA. Transcriptional downregulation of CMA genes may further contribute to CMA decline, especially in males. These findings suggest that CMA differences may influence organ vulnerability to age-related degeneration.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"691-708"},"PeriodicalIF":17.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination. 单细胞免疫老化时钟揭示了感染和接种过程中个体间的异质性。
IF 17
Nature aging Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1038/s43587-025-00819-z
Wenchao Li, Zhenhua Zhang, Saumya Kumar, Javier Botey-Bataller, Martijn Zoodsma, Ali Ehsani, Qiuyao Zhan, Ahmed Alaswad, Liang Zhou, Inge Grondman, Valerie Koeken, Jian Yang, Gang Wang, Sonja Volland, Tania O Crişan, Leo A B Joosten, Thomas Illig, Cheng-Jian Xu, Mihai G Netea, Yang Li
{"title":"Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination.","authors":"Wenchao Li, Zhenhua Zhang, Saumya Kumar, Javier Botey-Bataller, Martijn Zoodsma, Ali Ehsani, Qiuyao Zhan, Ahmed Alaswad, Liang Zhou, Inge Grondman, Valerie Koeken, Jian Yang, Gang Wang, Sonja Volland, Tania O Crişan, Leo A B Joosten, Thomas Illig, Cheng-Jian Xu, Mihai G Netea, Yang Li","doi":"10.1038/s43587-025-00819-z","DOIUrl":"10.1038/s43587-025-00819-z","url":null,"abstract":"<p><p>Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status remains unclear. Here we developed robust, cell-type-specific aging clocks (sc-ImmuAging) for the myeloid and lymphoid immune cell populations in circulation within peripheral blood mononuclear cells, using single-cell RNA-sequencing data from 1,081 healthy individuals aged from 18 to 97 years. Application of sc-ImmuAging to transcriptome data of patients with COVID-19 revealed notable age acceleration in monocytes, which decreased during recovery. Furthermore, inter-individual variations in immune aging induced by vaccination were identified, with individuals exhibiting elevated baseline interferon response genes showing age rejuvenation in CD8<sup>+</sup> T cells after BCG vaccination. sc-ImmuAging provides a powerful tool for decoding immune aging dynamics, offering insights into age-related immune alterations and potential interventions to promote healthy aging.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"607-621"},"PeriodicalIF":17.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palliative care use in Taiwanese older adults 台湾老年人缓和疗护之使用。
IF 17
Nature aging Pub Date : 2025-03-11 DOI: 10.1038/s43587-025-00843-z
Anna Kriebs
{"title":"Palliative care use in Taiwanese older adults","authors":"Anna Kriebs","doi":"10.1038/s43587-025-00843-z","DOIUrl":"10.1038/s43587-025-00843-z","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"339-339"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposing the exposome in aging 在衰老中暴露暴露者。
IF 17
Nature aging Pub Date : 2025-03-11 DOI: 10.1038/s43587-025-00845-x
George Andrew S. Inglis
{"title":"Exposing the exposome in aging","authors":"George Andrew S. Inglis","doi":"10.1038/s43587-025-00845-x","DOIUrl":"10.1038/s43587-025-00845-x","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"340-340"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease 亚细胞蛋白质组学和iPSC模型揭示了阿尔茨海默病轴突病理的可逆机制。
IF 17
Nature aging Pub Date : 2025-03-10 DOI: 10.1038/s43587-025-00823-3
Yifei Cai, Jean Kanyo, Rashaun Wilson, Shveta Bathla, Pablo Leal Cardozo, Lei Tong, Shanshan Qin, Lukas A. Fuentes, Iguaracy Pinheiro-de-Sousa, Tram Huynh, Liyuan Sun, Mohammad Shahid Mansuri, Zichen Tian, Hao-Ran Gan, Amber Braker, Hoang Kim Trinh, Anita Huttner, TuKiet T. Lam, Evangelia Petsalaki, Kristen J. Brennand, Angus C. Nairn, Jaime Grutzendler
{"title":"Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease","authors":"Yifei Cai,&nbsp;Jean Kanyo,&nbsp;Rashaun Wilson,&nbsp;Shveta Bathla,&nbsp;Pablo Leal Cardozo,&nbsp;Lei Tong,&nbsp;Shanshan Qin,&nbsp;Lukas A. Fuentes,&nbsp;Iguaracy Pinheiro-de-Sousa,&nbsp;Tram Huynh,&nbsp;Liyuan Sun,&nbsp;Mohammad Shahid Mansuri,&nbsp;Zichen Tian,&nbsp;Hao-Ran Gan,&nbsp;Amber Braker,&nbsp;Hoang Kim Trinh,&nbsp;Anita Huttner,&nbsp;TuKiet T. Lam,&nbsp;Evangelia Petsalaki,&nbsp;Kristen J. Brennand,&nbsp;Angus C. Nairn,&nbsp;Jaime Grutzendler","doi":"10.1038/s43587-025-00823-3","DOIUrl":"10.1038/s43587-025-00823-3","url":null,"abstract":"Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer’s disease (AD), where they impair axonal electrical conduction, disrupt neural circuits and correlate with AD severity. Despite their importance, the mechanisms underlying spheroid formation remain incompletely understood. To address this, we developed a proximity labeling approach to uncover the proteome of spheroids in human postmortem and mouse brains. Additionally, we established a human induced pluripotent stem cell (iPSC)-derived AD model enabling mechanistic investigation and optical electrophysiology. These complementary approaches revealed the subcellular molecular architecture of spheroids and identified abnormalities in key biological processes, including protein turnover, cytoskeleton dynamics and lipid transport. Notably, the PI3K/AKT/mTOR pathway, which regulates these processes, was activated in spheroids. Furthermore, phosphorylated mTOR levels in spheroids correlated with AD severity in humans. Notably, mTOR inhibition in iPSC-derived neurons and mice ameliorated spheroid pathology. Altogether, our study provides a multidisciplinary toolkit for investigating mechanisms and therapeutic targets for axonal pathology in neurodegeneration. Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to dysregulated mTOR, cytoskeletal and lipid transport signaling.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"504-527"},"PeriodicalIF":17.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-025-00823-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan 小鼠的类似冬眠状态减缓了血液表观遗传老化,延长了健康寿命。
IF 17
Nature aging Pub Date : 2025-03-07 DOI: 10.1038/s43587-025-00830-4
Lorna Jayne, Aurora Lavin-Peter, Julian Roessler, Alexander Tyshkovskiy, Mateusz Antoszewski, Erika Ren, Aleksandar Markovski, Senmiao Sun, Hanqi Yao, Vijay G. Sankaran, Vadim N. Gladyshev, Robert T. Brooke, Steve Horvath, Eric C. Griffith, Sinisa Hrvatin
{"title":"A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan","authors":"Lorna Jayne,&nbsp;Aurora Lavin-Peter,&nbsp;Julian Roessler,&nbsp;Alexander Tyshkovskiy,&nbsp;Mateusz Antoszewski,&nbsp;Erika Ren,&nbsp;Aleksandar Markovski,&nbsp;Senmiao Sun,&nbsp;Hanqi Yao,&nbsp;Vijay G. Sankaran,&nbsp;Vadim N. Gladyshev,&nbsp;Robert T. Brooke,&nbsp;Steve Horvath,&nbsp;Eric C. Griffith,&nbsp;Sinisa Hrvatin","doi":"10.1038/s43587-025-00830-4","DOIUrl":"10.1038/s43587-025-00830-4","url":null,"abstract":"Torpor and hibernation are extreme physiological adaptations of homeotherms associated with pro-longevity effects. Yet the underlying mechanisms of how torpor affects aging, and whether hypothermic and hypometabolic states can be induced to slow aging and increase healthspan, remain unknown. Here we demonstrate that the activity of a spatially defined neuronal population in the preoptic area, which has previously been identified as a torpor-regulating brain region, is sufficient to induce a torpor-like state (TLS) in mice. Prolonged induction of TLS slows epigenetic aging across multiple tissues and improves healthspan. We isolate the effects of decreased metabolic rate, long-term caloric restriction, and decreased core body temperature (Tb) on blood epigenetic aging and find that the decelerating effect of TLSs on aging is mediated by decreased Tb. Taken together, our findings provide novel mechanistic insight into the decelerating effects of torpor and hibernation on aging and support the growing body of evidence that Tb is an important mediator of the aging processes. Dissecting the effects of hypothermic and hypometabolic states on aging processes, the authors show that activation of neurons in the preoptic area induces a torpor-like state in mice that slows epigenetic aging and improves healthspan. These pro-longevity effects are mediated by reduced Tb, reinforcing evidence that Tb is a key mediator of aging processes.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"437-449"},"PeriodicalIF":17.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-025-00830-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cold is hot for slowing aging 冷是热,可以延缓衰老。
IF 17
Nature aging Pub Date : 2025-03-07 DOI: 10.1038/s43587-025-00817-1
Matteo Cerri
{"title":"Cold is hot for slowing aging","authors":"Matteo Cerri","doi":"10.1038/s43587-025-00817-1","DOIUrl":"10.1038/s43587-025-00817-1","url":null,"abstract":"Hrvatin and colleagues explore the antiaging mechanisms of torpor, and separate the roles of metabolic rate and body temperature. The study demonstrates that hypothermia, and not hypometabolism, drives deceleration of epigenetic aging, which positions body temperature as a pivotal target in aging research.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 3","pages":"344-345"},"PeriodicalIF":17.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信