Skin health and biological aging.

IF 17 Q1 CELL BIOLOGY
David Furman, Johan Auwerx, Anne-Laure Bulteau, George Church, Virginie Couturaud, Laure Crabbe, Kelvin J A Davies, Anabelle Decottignies, Vadim N Gladyshev, Brian K Kennedy, Nicola Neretti, Carine Nizard, Karl Pays, Daisy Robinton, Vittorio Sebastiano, Rachel E B Watson, Meng C Wang, Knut Woltjen
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引用次数: 0

Abstract

Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome and its effects on systemic aging. The complex interplay across hallmarks of aging in the skin and systemic biological aging suggests that physiological processes associated with skin aging influence, and are influenced by, systemic hallmarks of aging. This bidirectional relationship provides potential avenues for the prevention of accelerated biological aging and the identification of therapeutic targets. We provide a review of the interactions between skin exposure, aging hallmarks in the skin and associated systemic changes, and their implications in treatment and disease. We also discuss key questions that need to be addressed to maintain skin and overall health, highlighting the need for the development of precise biomarkers and advanced skin models.

皮肤健康与生物老化。
越来越多的证据表明,环境暴露(统称为“暴露体”)会加速生物衰老。皮肤作为最大和最暴露的器官,可以被视为深入探索暴露体及其对全身衰老影响的“窗口”。皮肤衰老特征和全身生物衰老之间复杂的相互作用表明,与皮肤衰老相关的生理过程影响并受全身衰老特征的影响。这种双向关系为预防加速的生物衰老和确定治疗靶点提供了潜在的途径。我们提供了皮肤暴露,皮肤老化标志和相关系统变化之间的相互作用,以及它们对治疗和疾病的影响的综述。我们还讨论了需要解决的关键问题,以保持皮肤和整体健康,强调需要发展精确的生物标志物和先进的皮肤模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
14.70
自引率
0.00%
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