Nature aging最新文献_第8页

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging. KLRG1识别随年龄增长而积累线粒体改变的调节性T细胞。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.1038/s43587-025-00855-9

Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M Gómez de Las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M Fernández-Díaz, María Beatriz Álvarez-Flores, Ana Ramírez de Molina, Sascha Jung, Antonio Del Sol, Virginia Zorita, Fátima Sánchez-Cabo, Carlos Torroja, María Mittelbrunn

{"title":"KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging.","authors":"Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M Gómez de Las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M Fernández-Díaz, María Beatriz Álvarez-Flores, Ana Ramírez de Molina, Sascha Jung, Antonio Del Sol, Virginia Zorita, Fátima Sánchez-Cabo, Carlos Torroja, María Mittelbrunn","doi":"10.1038/s43587-025-00855-9","DOIUrl":"10.1038/s43587-025-00855-9","url":null,"abstract":"Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification of age-associated T cell subsets in systematic larger analysis in mice. We use this panel to evaluate at the single-cell level mitochondrial and senescence marks in the different age-associated CD4+ T cell subpopulations. Our analysis identifies a subpopulation of regulatory T (Treg) cells that is characterized by the extracellular expression of the co-inhibitory molecule killer cell lectin-like receptor subfamily G member 1 (KLRG1) and accumulates with aging in humans and mice. KLRG1-expressing Treg cells display senescence features such as mitochondrial alterations, increased expression of cell-cycle regulators and genomic DNA damage. Functionally, KLRG1+ Treg cells show a reduced suppressive activity in vivo accompanied by a pro-inflammatory phenotype.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"799-815"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. 症状前帕金森病血液检测定量重复序列基序在转移RNA片段。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1038/s43587-025-00851-z

Nimrod Madrer, Shani Vaknine-Treidel, Tamara Zorbaz, Yonat Tzur, Estelle R Bennett, Paz Drori, Nitzan Suissa, David S Greenberg, Eitan Lerner, Eyal Soreq, Iddo Paldor, Hermona Soreq

{"title":"Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments.","authors":"Nimrod Madrer, Shani Vaknine-Treidel, Tamara Zorbaz, Yonat Tzur, Estelle R Bennett, Paz Drori, Nitzan Suissa, David S Greenberg, Eitan Lerner, Eyal Soreq, Iddo Paldor, Hermona Soreq","doi":"10.1038/s43587-025-00851-z","DOIUrl":"10.1038/s43587-025-00851-z","url":null,"abstract":"Early, efficient Parkinson's disease (PD) tests may facilitate pre-symptomatic diagnosis and disease-modifying therapies. Here we report elevated levels of PD-specific transfer RNA fragments carrying a conserved sequence motif (RGTTCRA-tRFs) in the substantia nigra, cerebrospinal fluid and blood of patients with PD. A whole blood qPCR test detecting elevated RGTTCRA-tRFs and reduced mitochondrial-originated tRFs (MT-tRFs) segregated pre-symptomatic patients with PD from controls (area under the receiver operating characteristic curve (ROC-AUC) of 0.75 versus 0.71 based on traditional clinical scoring). Strengthening PD relevance, patients carrying PD-related mutations presented higher blood RGTTCRA-tRFs/MT-tRFs ratios than mutation-carrying non-symptomatic controls, and RGTTCRA-tRF levels decreased in patients' blood after deep brain stimulation. Furthermore, RGTTCRA-tRFs complementarity to ribosomal RNA and the translation-supporting LeuCAG3-tRF might aggravate PD via translational inhibition, as reflected by disrupted ribosomal association of RGTTCRA-tRFs in depolarized neuroblastoma cells. Our findings show tRF involvement in PD and suggest a potential simple and safe blood test that may aid clinicians in pre-symptomatic PD diagnosis after validation in larger independent cohorts.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"868-882"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recycling tRNA fragment 'trash' into treasure. 将tRNA片段“垃圾”转化为财富。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00870-w

Frank A Middleton

引用次数: 0

The effect of ambient air pollution (PM_2.5) on dementia risk. 环境空气污染（PM2.5）对痴呆风险的影响。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00865-7

引用次数: 0

Aging, regeneration and whole-body rejuvenation in long-lived planarians. 长寿涡虫的衰老、再生和全身年轻化。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00863-9

引用次数: 0

Healthy diets for healthy aging. 健康饮食促进健康老龄化。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00871-9

Hannah Walters

引用次数: 0

Valuing caregiving is a prerequisite for the wellbeing economy and mental wealth. 重视照顾是幸福经济和精神财富的先决条件。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00868-4

Mouna Sawan, Saman Khalatbari-Soltani, Anita van Zwieten, Suraj Samtani, Jo-An Occhipinti, J Jaime Miranda

引用次数: 0

Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer. 单细胞和空间RNA测序鉴定早期和晚发性前列腺癌不同的微环境和进展特征。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1038/s43587-025-00842-0

Yifei Cheng, Bingxin Liu, Junyi Xin, Xiaobin Wu, Wenchao Li, Jinwei Shang, Jiajin Wu, Zhengdong Zhang, Bin Xu, Mulong Du, Gong Cheng, Meilin Wang

{"title":"Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.","authors":"Yifei Cheng, Bingxin Liu, Junyi Xin, Xiaobin Wu, Wenchao Li, Jinwei Shang, Jiajin Wu, Zhengdong Zhang, Bin Xu, Mulong Du, Gong Cheng, Meilin Wang","doi":"10.1038/s43587-025-00842-0","DOIUrl":"10.1038/s43587-025-00842-0","url":null,"abstract":"The clinical and pathological outcomes differ between early-onset (diagnosed in men ≤55 years of age) and late-onset prostate cancer, potentially attributed to the changes in hormone levels and immune activities associated with aging. Exploring the heterogeneity therein holds potential for developing age-specific precision interventions. Here, through single-cell and spatial transcriptomic analyses of prostate cancer tissues, we identified that an androgen response-related transcriptional meta-program (AR-MP) might underlie the age-related heterogeneity of tumor cells and microenvironment. APOE+ tumor-associated macrophages infiltrated AR-MP-activated tumor cells in early-onset prostate cancer, potentially facilitating tumor progression and immunosuppression. By contrast, inflammatory cancer-associated fibroblasts in late-onset prostate cancer correlated with downregulation of AR-MP of tumor cells and increased epithelial-to-mesenchymal transition and pre-existing castration resistance, which may also be linked to smoking. This study provides potential insights for tailoring precision treatments by age groups, emphasizing interventions that include targeting AR and tumor-associated macrophages in young patients but anchoring epithelial-to-mesenchymal transition and inflammatory cancer-associated fibroblasts in old counterparts.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"909-928"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. 反转录转座子衍生的衣壳基因PNMA1和PNMA4维持生殖能力。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1038/s43587-025-00852-y

Thomas W P Wood, William S Henriques, Harrison B Cullen, Mayra Romero, Cecilia S Blengini, Shreya Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaelle Laureau, Alexei Chemiakine, Rishad C Khondker, José V V Isola, Michael B Stout, Vincenzo A Gennarino, Binyam Mogessie, Devanshi Jain, Karen Schindler, Yousin Suh, Blake Wiedenheft, Luke E Berchowitz

{"title":"The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.","authors":"Thomas W P Wood, William S Henriques, Harrison B Cullen, Mayra Romero, Cecilia S Blengini, Shreya Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaelle Laureau, Alexei Chemiakine, Rishad C Khondker, José V V Isola, Michael B Stout, Vincenzo A Gennarino, Binyam Mogessie, Devanshi Jain, Karen Schindler, Yousin Suh, Blake Wiedenheft, Luke E Berchowitz","doi":"10.1038/s43587-025-00852-y","DOIUrl":"10.1038/s43587-025-00852-y","url":null,"abstract":"Almost half of the human genome consists of retrotransposons-'parasitic' sequences that insert themselves into the host genome via an RNA intermediate. Although most of these sequences are silenced or mutationally deactivated, they can present opportunities for evolutionary innovation: mutation of a deteriorating retrotransposon can result in a gene that provides a selective advantage to the host in a process termed 'domestication'1-3. The PNMA family of gag-like capsid genes was domesticated from an ancient vertebrate retrotransposon of the Metaviridae clade at least 100 million years ago4,5. PNMA1 and PNMA4 are positively regulated by the master germ cell transcription factors MYBL1 and STRA8, and their transcripts are bound by the translational regulator DAZL during gametogenesis6. This developmental regulation of PNMA1 and PNMA4 expression in gonadal tissue suggested to us that they might serve a reproductive function. Through the analysis of donated human ovaries, genome-wide association studies (GWASs) and mouse models, we found that PNMA1 and PNMA4 are necessary for the maintenance of a normal reproductive lifespan. These proteins self-assemble into capsid-like structures that exit human cells, and we observed large PNMA4 particles in mouse male gonadal tissue that contain RNA and are consistent with capsid formation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"765-779"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial aging is accompanied by H3K27ac and PGR loss. 子宫内膜衰老伴随着H3K27ac和PGR的丢失。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-05-20 DOI: 10.1038/s43587-025-00859-5

Yue Wang, Ping Zhou, Hongying Shan, Xiyao Liu, Ming Cheng, Zhenhong Ye, Xiunan Chen, Baoying Liao, Tianliu Peng, Chenxi Xiao, Ziying Huang, Yunshu Dong, Yang Yu, Heng Pan, Rong Li

{"title":"Endometrial aging is accompanied by H3K27ac and PGR loss.","authors":"Yue Wang, Ping Zhou, Hongying Shan, Xiyao Liu, Ming Cheng, Zhenhong Ye, Xiunan Chen, Baoying Liao, Tianliu Peng, Chenxi Xiao, Ziying Huang, Yunshu Dong, Yang Yu, Heng Pan, Rong Li","doi":"10.1038/s43587-025-00859-5","DOIUrl":"10.1038/s43587-025-00859-5","url":null,"abstract":"Whether and how endometrial aging affects fertility remains unclear. In our in-house clinical cohort at the Center for Reproductive Medicine of Peking University Third Hospital (n = 1,149), we observed adverse pregnancy outcomes in the middle-aged group after excluding aneuploid embryos, implying the negative impact of endometrial aging on fertility. To understand endometrial aging, we performed comprehensive transcriptomic profiling of the mid-secretory endometrium of young (<35 years) and middle-aged (≥35 years) patients. This analysis revealed that H3K27ac loss is linked to impaired endometrial receptivity in the middle-aged group. We eliminated H3K27ac in young human endometrial stromal cells and observed reduced progesterone receptor (PGR), a critical regulator of endometrial receptivity. Lastly, we validated the association between H3K27ac/PGR loss and uterine aging in a mouse model. Our findings establish H3K27ac as a critical regulator of PGR and demonstrate that endometrial H3K27ac loss is associated with aging-related fertility decline. This work provides valuable insights into enhancing the safety and efficacy of assisted reproductive technologies in future clinical practices.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 5","pages":"816-830"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0