Nature aging最新文献_第7页

Healthy diets for healthy aging. 健康饮食促进健康老龄化。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00871-9

Hannah Walters

引用次数: 0

Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer. 单细胞和空间RNA测序鉴定早期和晚发性前列腺癌不同的微环境和进展特征。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-10 DOI: 10.1038/s43587-025-00842-0

Yifei Cheng, Bingxin Liu, Junyi Xin, Xiaobin Wu, Wenchao Li, Jinwei Shang, Jiajin Wu, Zhengdong Zhang, Bin Xu, Mulong Du, Gong Cheng, Meilin Wang

{"title":"Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.","authors":"Yifei Cheng, Bingxin Liu, Junyi Xin, Xiaobin Wu, Wenchao Li, Jinwei Shang, Jiajin Wu, Zhengdong Zhang, Bin Xu, Mulong Du, Gong Cheng, Meilin Wang","doi":"10.1038/s43587-025-00842-0","DOIUrl":"10.1038/s43587-025-00842-0","url":null,"abstract":"The clinical and pathological outcomes differ between early-onset (diagnosed in men ≤55 years of age) and late-onset prostate cancer, potentially attributed to the changes in hormone levels and immune activities associated with aging. Exploring the heterogeneity therein holds potential for developing age-specific precision interventions. Here, through single-cell and spatial transcriptomic analyses of prostate cancer tissues, we identified that an androgen response-related transcriptional meta-program (AR-MP) might underlie the age-related heterogeneity of tumor cells and microenvironment. APOE+ tumor-associated macrophages infiltrated AR-MP-activated tumor cells in early-onset prostate cancer, potentially facilitating tumor progression and immunosuppression. By contrast, inflammatory cancer-associated fibroblasts in late-onset prostate cancer correlated with downregulation of AR-MP of tumor cells and increased epithelial-to-mesenchymal transition and pre-existing castration resistance, which may also be linked to smoking. This study provides potential insights for tailoring precision treatments by age groups, emphasizing interventions that include targeting AR and tumor-associated macrophages in young patients but anchoring epithelial-to-mesenchymal transition and inflammatory cancer-associated fibroblasts in old counterparts.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"909-928"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valuing caregiving is a prerequisite for the wellbeing economy and mental wealth. 重视照顾是幸福经济和精神财富的先决条件。

IF 17

Nature aging Pub Date : 2025-05-01 DOI: 10.1038/s43587-025-00868-4

Mouna Sawan, Saman Khalatbari-Soltani, Anita van Zwieten, Suraj Samtani, Jo-An Occhipinti, J Jaime Miranda

引用次数: 0

The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. 反转录转座子衍生的衣壳基因PNMA1和PNMA4维持生殖能力。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1038/s43587-025-00852-y

Thomas W P Wood, William S Henriques, Harrison B Cullen, Mayra Romero, Cecilia S Blengini, Shreya Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaelle Laureau, Alexei Chemiakine, Rishad C Khondker, José V V Isola, Michael B Stout, Vincenzo A Gennarino, Binyam Mogessie, Devanshi Jain, Karen Schindler, Yousin Suh, Blake Wiedenheft, Luke E Berchowitz

{"title":"The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity.","authors":"Thomas W P Wood, William S Henriques, Harrison B Cullen, Mayra Romero, Cecilia S Blengini, Shreya Sarathy, Julia Sorkin, Hilina Bekele, Chen Jin, Seungsoo Kim, Xifan Wang, Raphaelle Laureau, Alexei Chemiakine, Rishad C Khondker, José V V Isola, Michael B Stout, Vincenzo A Gennarino, Binyam Mogessie, Devanshi Jain, Karen Schindler, Yousin Suh, Blake Wiedenheft, Luke E Berchowitz","doi":"10.1038/s43587-025-00852-y","DOIUrl":"10.1038/s43587-025-00852-y","url":null,"abstract":"Almost half of the human genome consists of retrotransposons-'parasitic' sequences that insert themselves into the host genome via an RNA intermediate. Although most of these sequences are silenced or mutationally deactivated, they can present opportunities for evolutionary innovation: mutation of a deteriorating retrotransposon can result in a gene that provides a selective advantage to the host in a process termed 'domestication'1-3. The PNMA family of gag-like capsid genes was domesticated from an ancient vertebrate retrotransposon of the Metaviridae clade at least 100 million years ago4,5. PNMA1 and PNMA4 are positively regulated by the master germ cell transcription factors MYBL1 and STRA8, and their transcripts are bound by the translational regulator DAZL during gametogenesis6. This developmental regulation of PNMA1 and PNMA4 expression in gonadal tissue suggested to us that they might serve a reproductive function. Through the analysis of donated human ovaries, genome-wide association studies (GWASs) and mouse models, we found that PNMA1 and PNMA4 are necessary for the maintenance of a normal reproductive lifespan. These proteins self-assemble into capsid-like structures that exit human cells, and we observed large PNMA4 particles in mouse male gonadal tissue that contain RNA and are consistent with capsid formation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":" ","pages":"765-779"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow. 富含线粒体的造血干细胞表现出更高的自我更新能力，在衰老的骨髓中茁壮成长。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI: 10.1038/s43587-025-00828-y

Haruhito Totani, Takayoshi Matsumura, Rui Yokomori, Terumasa Umemoto, Yuji Takihara, Chong Yang, Lee Hui Chua, Atsushi Watanabe, Takaomi Sanda, Toshio Suda

引用次数: 0

Endometrial aging is accompanied by H3K27ac and PGR loss. 子宫内膜衰老伴随着H3K27ac和PGR的丢失。

IF 17

Nature aging Pub Date : 2025-05-01 Epub Date: 2025-05-20 DOI: 10.1038/s43587-025-00859-5

Yue Wang, Ping Zhou, Hongying Shan, Xiyao Liu, Ming Cheng, Zhenhong Ye, Xiunan Chen, Baoying Liao, Tianliu Peng, Chenxi Xiao, Ziying Huang, Yunshu Dong, Yang Yu, Heng Pan, Rong Li

{"title":"Endometrial aging is accompanied by H3K27ac and PGR loss.","authors":"Yue Wang, Ping Zhou, Hongying Shan, Xiyao Liu, Ming Cheng, Zhenhong Ye, Xiunan Chen, Baoying Liao, Tianliu Peng, Chenxi Xiao, Ziying Huang, Yunshu Dong, Yang Yu, Heng Pan, Rong Li","doi":"10.1038/s43587-025-00859-5","DOIUrl":"10.1038/s43587-025-00859-5","url":null,"abstract":"Whether and how endometrial aging affects fertility remains unclear. In our in-house clinical cohort at the Center for Reproductive Medicine of Peking University Third Hospital (n = 1,149), we observed adverse pregnancy outcomes in the middle-aged group after excluding aneuploid embryos, implying the negative impact of endometrial aging on fertility. To understand endometrial aging, we performed comprehensive transcriptomic profiling of the mid-secretory endometrium of young (<35 years) and middle-aged (≥35 years) patients. This analysis revealed that H3K27ac loss is linked to impaired endometrial receptivity in the middle-aged group. We eliminated H3K27ac in young human endometrial stromal cells and observed reduced progesterone receptor (PGR), a critical regulator of endometrial receptivity. Lastly, we validated the association between H3K27ac/PGR loss and uterine aging in a mouse model. Our findings establish H3K27ac as a critical regulator of PGR and demonstrate that endometrial H3K27ac loss is associated with aging-related fertility decline. This work provides valuable insights into enhancing the safety and efficacy of assisted reproductive technologies in future clinical practices.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 5","pages":"816-830"},"PeriodicalIF":17.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay of somatic mutations and epigenetic aging clocks. 体细胞突变与表观遗传衰老时钟的相互作用。

IF 17

Nature aging Pub Date : 2025-04-01 DOI: 10.1038/s43587-025-00846-w

Wolfgang Wagner

引用次数: 0

Somatic mutation as an explanation for epigenetic aging. 体细胞突变是表观遗传衰老的一种解释。

IF 17

Nature aging Pub Date : 2025-04-01 Epub Date: 2025-01-13 DOI: 10.1038/s43587-024-00794-x

Zane Koch, Adam Li, Daniel S Evans, Steven Cummings, Trey Ideker

引用次数: 0

FGF21 keeps the thymus young. FGF21使胸腺保持年轻。