Nature aging最新文献

{"title":"Plasma proteins associated with the brain age gap","authors":"Erik C. B. Johnson","doi":"10.1038/s43587-024-00780-3","DOIUrl":"10.1038/s43587-024-00780-3","url":null,"abstract":"Accelerated brain aging is a risk factor for dementia, and resilience to normal brain aging is associated with cognitive preservation. Liu and colleagues explore plasma proteomic changes associated with brain aging and identify peaks of brain aging-related protein changes in middle-aged or older adults.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"15-16"},"PeriodicalIF":17.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seventy really may be the new sixty for English baby boomers","authors":"","doi":"10.1038/s43587-024-00796-9","DOIUrl":"10.1038/s43587-024-00796-9","url":null,"abstract":"A study examined trends in intrinsic capacity, a comprehensive measure of cognitive, locomotor, psychological and sensory capacities that was recently developed by the World Health Organization. The results indicate that older adults in England today seem to be experiencing far higher levels of physical and mental functioning than did previous generations at the same age.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"19-20"},"PeriodicalIF":17.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing the promise and risks of geroscience interventions","authors":"Alan A. Cohen, John R. Beard, Luigi Ferrucci, Tamàs Fülöp, Vadim N. Gladyshev, Mahdi Moqri, Marcel G. M. Olde Rikkert, Martin Picard","doi":"10.1038/s43587-024-00788-9","DOIUrl":"10.1038/s43587-024-00788-9","url":null,"abstract":"Although the emerging field of geroscience holds great promise for identifying new approaches to improve healthspan, several risks of the current framework are underappreciated. Long time horizons, challenges in identifying causality-driven surrogate biomarkers of aging, and the potential for biological trade-offs and antagonistic effects across various timescales mean it will be hard to know when such interventions have a net benefit. We propose eight strategies to mitigate these risks going forwards.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"4-8"},"PeriodicalIF":17.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring","authors":"Stefania Benonisdottir, Vincent J. Straub, Augustine Kong, Melinda C. Mills","doi":"10.1038/s43587-024-00800-2","DOIUrl":"10.1038/s43587-024-00800-2","url":null,"abstract":"","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"332-332"},"PeriodicalIF":17.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00800-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress induces senescence build-up early in life","authors":"Victor Lau, Ifeoluwa Awogbindin, Marie-Ève Tremblay","doi":"10.1038/s43587-024-00774-1","DOIUrl":"10.1038/s43587-024-00774-1","url":null,"abstract":"Chronic stress markedly affects health, but the underlying mechanisms have remained unexplored. Using two stress paradigms (simulating bullying and confinement), Lyons and colleagues now demonstrate that even a brief, single-month exposure to stress can induce neuronal senescence in mice.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"12-14"},"PeriodicalIF":17.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring aging-related tissue homeostasis via reactivated innate immunotherapy","authors":"","doi":"10.1038/s43587-024-00782-1","DOIUrl":"10.1038/s43587-024-00782-1","url":null,"abstract":"A chimeric peptide designed to recruit immune cells has been shown to enhance the ‘coupling’ between senescent cells and natural killer cells to promote immune clearance of senescent cells for restoration of tissue homeostasis in liver fibrosis, lung injury, cancer and even natural aging in mice.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"17-18"},"PeriodicalIF":17.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging","authors":"Charlène Iltis, Iryna Moskalevska, Antoine Debiesse, Laetitia Seguin, Christina Fissoun, Ludovic Cervera, Lyvia Moudombi, Maude Ardin, Anthony Ferrari, Coline Eliott, Didier Pisani, Alexandre Ottaviani, Manon Bourinet, Carmelo Luci, Philippe Gual, Gabriela Makulyte, David Bernard, Manon Durandy, Lou C. Duret, Tynhinane Hamidouche, Sarah Kunz, Olivier Croce, Clément Delannoy, Yann Guérardel, Fabrice Allain, Paul Hofman, Delphine Benarroch-Popivker, Laurence Bianchini, Berengère Dadone-Montaudie, Estelle Cosson, Julien Guglielmi, Thierry Pourcher, Véronique M. Braud, Marina Shkreli, Yves-Marie Pers, Christian Jorgensen, Jean-Marc Brondello, Chloé C. Féral, Marie-Cécile Michallet, Eric Gilson, Julien Cherfils-Vicini","doi":"10.1038/s43587-024-00776-z","DOIUrl":"10.1038/s43587-024-00776-z","url":null,"abstract":"Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance. In mice, we found that targeting GD3+ senescent cells with anti-GD3 immunotherapy attenuated the development of experimentally induced or age-related lung and liver fibrosis and age-related bone remodeling. These results demonstrate that GD3 upregulation confers immune privilege to senescent cells. We propose that GD3 acts as a senescence immune checkpoint (SIC) that allows senescent cells to escape immunosurveillance and to trigger immune anergy during aging. This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-related diseases.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"219-236"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00776-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog","authors":"Sophia Magkouta, Dimitris Veroutis, Angelos Papaspyropoulos, Maria Georgiou, Nikolaos Lougiakis, Natassa Pippa, Sophia Havaki, Anastasia Palaiologou, Dimitris-Foivos Thanos, Konstantinos Kambas, Nefeli Lagopati, Nikos Boukos, Nicole Pouli, Panagiotis Marakos, Athanassios Kotsinas, Dimitris Thanos, Konstantinos Evangelou, Fotios Sampaziotis, Constantin Tamvakopoulos, Stergios Pispas, Russell Petty, Nicholas Kotopoulos, Vassilis G. Gorgoulis","doi":"10.1038/s43587-024-00747-4","DOIUrl":"10.1038/s43587-024-00747-4","url":null,"abstract":"The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging. Enhancing the selectivity of senolytic treatments toward senescent cells stands to reduce the adverse effects associated with existing senolytic interventions. Taking advantage of lipofuscin accumulation in senescent cells, we describe here the development of a highly efficient senolytic platform consisting of a lipofuscin-binding domain scaffold, which can be conjugated with a senolytic drug via an ester bond. As a proof of concept, we present the generation of GL392, a senolytic compound that carries a dasatinib senolytic moiety. Encapsulation of the GL392 compound in a micelle nanocarrier (termed mGL392) allows for both in vitro and in vivo (in mice) selective elimination of senescent cells via targeted release of the senolytic agent with minimal systemic toxicity. Our findings suggest that this platform could be used to enhance targeting of senotherapeutics toward senescent cells. Exploiting the selective accumulation of lipofuscin in senescent cells, the authors developed a targeted senolytic platform. As proof of concept, they show that selective delivery of dasatinib elicits senolysis with minimal toxicity, in vitro, in organoids and in mice.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"162-175"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00747-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas","authors":"Agustina Legaz, Florencia Altschuler, Raul Gonzalez-Gomez, Hernán Hernández, Sandra Baez, Joaquín Migeot, Sol Fittipaldi, Vicente Medel, Marcelo Adrián Maito, María E. Godoy, Sebastián Moguilner, Josephine Cruzat, Carlos Coronel-Oliveros, Enzo Tagliazuchi, Hernando Santamaria Garcia, Francesca R. Farina, Pablo Reyes, Shireen Javandel, Adolfo M. García, Álvaro Deleglise, Diana L. Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I. Behrens, Nilton Custodio, Catalina Trujillo-Llano, Juan F. Cardona, Pablo Barttfeld, Ignacio L. Brusco, Martín A. Bruno, Ana L. Sosa Ortiz, Stefanie D. Pina-Escudero, Leonel T. Takada, Elisa de Paula França Resende, Katherine L. Possin, Maira Okada de Oliveira, Kun Hu, Francisco Lopera, Brian Lawlor, Victor Valcour, Jennifer S. Yokoyama, Bruce Miller, Agustin Ibañez","doi":"10.1038/s43587-024-00781-2","DOIUrl":"10.1038/s43587-024-00781-2","url":null,"abstract":"Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations. The authors find that structural economic inequality is linked to reduced brain volume and connectivity in middle-aged and older adults across the Americas, more so in Alzheimer’s disease than in frontotemporal dementia. The findings emphasize the biological embedding of inequality in aging and dementia.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"259-274"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global analysis of adaptation to societal aging across low-, middle- and high-income countries using the Global Aging Society Index","authors":"Cynthia Chen, Julian Lim, Jemima Koh, John Beard, John W. Rowe, for the Research Network on an Aging Society","doi":"10.1038/s43587-024-00772-3","DOIUrl":"10.1038/s43587-024-00772-3","url":null,"abstract":"We have previously presented a multidimensional Aging Society Index, a weighted summation of five domains central to successful adaptation to societal aging: well-being, productivity and engagement, equity, cohesion and security, as a tool to assess countries’ adaptation to demographic transformation. As the index was based on data from developed countries and some of the individual metrics or weightings may not be well suited for application to low- and middle-income countries, we here present the scores on a modified index (Global Aging Society Index) on 143 countries distributed across the span of economic development. Only 5 out of 143 (3.5%) countries had higher scores for women than men. Countries with the most notable gender differences were primarily low-income countries. The multidimensional index permits cross-national comparisons and may facilitate the identification of targets for developing policies and programs to enhance the likelihood that older persons will age successfully. The authors score and rank the adaptation to societal aging across 143 countries using a newly developed index called the Global Aging Society Index, which may be helpful to identify targets for the development of policies and programs to enhance the likelihood that older people will age successfully.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 1","pages":"113-121"},"PeriodicalIF":17.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s43587-024-00772-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}