Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination.

IF 17 Q1 CELL BIOLOGY

Nature aging Pub Date : 2025-03-05 DOI:10.1038/s43587-025-00819-z

Wenchao Li, Zhenhua Zhang, Saumya Kumar, Javier Botey-Bataller, Martijn Zoodsma, Ali Ehsani, Qiuyao Zhan, Ahmed Alaswad, Liang Zhou, Inge Grondman, Valerie Koeken, Jian Yang, Gang Wang, Sonja Volland, Tania O Crişan, Leo A B Joosten, Thomas Illig, Cheng-Jian Xu, Mihai G Netea, Yang Li

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引用次数: 0

Abstract

Aging affects human immune system functionality, increasing susceptibility to immune-mediated diseases. While gene expression programs accurately reflect immune function, their relationship with biological immune aging and health status remains unclear. Here we developed robust, cell-type-specific aging clocks (sc-ImmuAging) for the myeloid and lymphoid immune cell populations in circulation within peripheral blood mononuclear cells, using single-cell RNA-sequencing data from 1,081 healthy individuals aged from 18 to 97 years. Application of sc-ImmuAging to transcriptome data of patients with COVID-19 revealed notable age acceleration in monocytes, which decreased during recovery. Furthermore, inter-individual variations in immune aging induced by vaccination were identified, with individuals exhibiting elevated baseline interferon response genes showing age rejuvenation in CD8⁺ T cells after BCG vaccination. sc-ImmuAging provides a powerful tool for decoding immune aging dynamics, offering insights into age-related immune alterations and potential interventions to promote healthy aging.

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衰老会影响人体免疫系统的功能，增加对免疫介导疾病的易感性。虽然基因表达程序能准确反映免疫功能，但它们与生物免疫衰老和健康状况的关系仍不清楚。在这里，我们利用来自 1081 名年龄在 18 至 97 岁之间的健康人的单细胞 RNA 序列数据，为外周血单核细胞中循环的髓系和淋巴免疫细胞群开发了稳健的细胞类型特异性衰老时钟（sc-ImmuAging）。将 sc-ImmuAging 应用于 COVID-19 患者的转录组数据时发现，单核细胞的年龄明显加快，而在恢复期则有所下降。sc-ImmuAging为解码免疫老化动态提供了一个强大的工具，有助于深入了解与年龄相关的免疫改变以及促进健康老化的潜在干预措施。

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来源期刊

Nature aging

CiteScore

14.70

自引率

0.00%

发文量