{"title":"The X-Age Project to construct a Chinese aging clock","authors":"Jiaming Li, Mengmeng Jiang, Qiaoran Wang, Zikai Zheng, Jianghua Shen, Jingyi Li, Muzhao Xiong, Yandong Zheng, Xiaoyong Lu, Yusheng Cai, Yanling Fan, Lingling Geng, Qianzhao Ji, Qianqian Peng, Shuhui Sun, Yuanyuan Wang, Zijuan Xin, Kaowen Yan, Yuanhan Yang, Jun Yu, Haoteng Yan, Ding Ai, Yongping Bai, Yan Bi, Xiu-Wu Bian, Pengcheng Bu, Jian-Ping Cai, Chun-Mei Cao, Feng Cao, Zhongwei Cao, Renjie Chai, Piu Chan, Chang Chen, Cheng-Shui Chen, Chunying Chen, Di Chen, Hou-Zao Chen, Lin Chen, Quan Chen, Xiao Chen, Xiaochun Chen, Yu Chen, Zi-Jiang Chen, Weimin Ci, Zhe Dai, Qiurong Ding, Birong Dong, Jiahong Dong, Jian-Gao Fan, Shiqing Feng, Xin Feng, Yun Feng, Xiaobing Fu, Xiaolong Fu, Feng Gao, Jiangang Gao, Qiang Gao, Shaorong Gao, Yonghao Gu, Youfei Guan, Feifan Guo, Jing-Dong J. Han, Haiping Hao, Jihui Hao, Fuchu He, Jinhan He, Ming He, Mingguang He, Qiyang He, Zhiying He, Zuhong He, Huashan Hong, Jiaxu Hong, Shengping Hou, Cheng Hu, Ping Hu, Zhibin Hu, Canhua Huang, Jun Huang, Kai Huang, Pengyu Huang, Xunming Ji, Yong Ji, Shunji Jia, Hong Jiang, Wenjian Jiang, Lingjing Jin, Zi-Bing Jin, Shenghong Ju, Zhenyu Ju, Qing-Peng Kong, Wei Kong, Wei-Jia Kong, Xiangqing Kong, Guanghua Lei, Geng-Lin Li, Ji Li, Jian Li, Mengfeng Li, Rong Li, Wei Li, Wei Li, Xiao-Jun Li, Xin Li, Qingfeng Liang, Zhen Liang, Haotian Lin, Baohua Liu, Cai-Yue Liu, Changsheng Liu, Feng Liu, Jianfeng Liu, Jun-Ping Liu, Ke Liu, Lin Liu, Pingsheng Liu, Qiang Liu, Qiang Liu, Tiemin Liu, Wenwen Liu, Xingguo Liu, Yajun Liu, Yong Liu, Youhua Liu, Youshuo Liu, Zhili Liu, Xiao Long, Yao Lu, Jian Luo, Xianghang Luo, Chunhong Ma, Shuai Ma, Xinran Ma, Jianhua Mao, Zhiyong Mao, Shyh-Chang Ng, Guangjun Nie, Yuyu Niu, Yaojin Peng, Jun Pu, Jieyu Qi, Li Qiang, Jie Qiao, Yingying Qin, Aijuan Qu, Jing Qu, Jie Ren, Ruibao Ren, Xiong Z. Ruan, Anbing Shi, Haibo Shi, Jie Shi, Kwok-Fai So, Moshi Song, Weihong Song, Zhou Songyang, Jiacan Su, Aijun Sun, Liang Sun, Qiang Sun, Yi Eve Sun, Yu Sun, Peifu Tang, Qi-Qun Tang, Yi Tang, Jun Tao, Ling Tao, Mei Tian, Xiao-Li Tian, Ye Tian, Xiaolin Tong, Cong-Yi Wang, Haibo Wang, Hongmei Wang, Huating Wang, Jianan Wang, Jianwei Wang, Jianwei Wang, Jiqiu Wang, Liheng Wang, Lin Wang, Miao Wang, Qiang Wang, Si Wang, Sijia Wang, Songlin Wang, Wengong Wang, Xiaoming Wang, Xiaoning Wang, Yan Wang, Yan-Jiang Wang, Yuan Wang, Yunfang Wang, Zhenning Wang, Xiawei Wei, Jianping Weng, Haitao Wu, Jihong Wu, Xiaohuan Xia, Yang Xia, Andy Peng Xiang, Guozhi Xiao, Junjie Xiao, Yichuan Xiao, Zhi-Xiong Jim Xiao, Zhengwei Xie, Wei Xiong, Aimin Xu, Hua Xu, Lingyan Xu, Ming Xu, Liying Yan, Jiayin Yang, Jichun Yang, Liu Yang, Yun-Gui Yang, Ze Yang, Zhenglin Yang, Hongjie Yao, Jing Ye, Chengqi Yi, Fan Yi, Honghua Yu, Yang Yu, Zhengrong Yu, Ti-Fei Yuan, Jirong Yue, Rui Yue, Chen Zhang, Chunxiang Zhang, Cuntai Zhang, Feng Zhang, Hongbo Zhang, Hongjia Zhang, Huijie Zhang, Jie Zhang, Jingjing Zhang, Licheng Zhang, Lingqiang Zhang, Luoying Zhang, Qingjiong Zhang, Wei Zhang, Weiping J. Zhang, Xin Zhang, Xuan Zhang, Yong Zhang, Yun-Wu Zhang, Zhanjun Zhang, Zhuohua Zhang, Bing Zhao, Guoguang Zhao, Jiajun Zhao, Meng Zhao, Tongbiao Zhao, Jialin C. Zheng, Junke Zheng, Zhuozhao Zheng, Huixia Zhou, Lili Zhou, Xiangtian Zhou, Yongsheng Zhou, Zhongjun Zhou, Lan Zhu, Yizhun Zhu, Zhiming Zhu, Wenjuan Zhuang, Weiguo Zou, Weiqi Zhang, Gang Pei, Guang-Hui Liu","doi":"10.1038/s43587-025-00935-w","DOIUrl":null,"url":null,"abstract":"The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age‐related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual’s physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions. In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 9","pages":"1669-1685"},"PeriodicalIF":19.4000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00935-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age‐related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual’s physiological and molecular state, across diverse Chinese cohorts. This Perspective outlines the core objectives, methodological framework and key deliverables of the X-Age Project, including cohort recruitment, standardized sample collection, multimodal data acquisition and clock model development. By integrating interdisciplinary expertise, we aim to provide a practical and scalable platform for understanding aging complexity and heterogeneity, early detection of accelerated aging and evaluation of aging interventions. In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.
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