{"title":"为内在能力开发一种基于血液的表观遗传时钟。","authors":"Xueqing Jia, Zuyun Liu","doi":"10.1038/s43587-025-00899-x","DOIUrl":null,"url":null,"abstract":"Intrinsic capacity, the composite of an individual’s physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to develop an epigenetic predictor of intrinsic capacity and pinpoint immune system dysfunction as a key driver of intrinsic capacity decline.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 7","pages":"1188-1190"},"PeriodicalIF":19.4000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Developing a blood-based epigenetic clock for intrinsic capacity\",\"authors\":\"Xueqing Jia, Zuyun Liu\",\"doi\":\"10.1038/s43587-025-00899-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Intrinsic capacity, the composite of an individual’s physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to develop an epigenetic predictor of intrinsic capacity and pinpoint immune system dysfunction as a key driver of intrinsic capacity decline.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":\"5 7\",\"pages\":\"1188-1190\"},\"PeriodicalIF\":19.4000,\"publicationDate\":\"2025-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-025-00899-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00899-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Developing a blood-based epigenetic clock for intrinsic capacity
Intrinsic capacity, the composite of an individual’s physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to develop an epigenetic predictor of intrinsic capacity and pinpoint immune system dysfunction as a key driver of intrinsic capacity decline.
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