IEEE transactions on biomedical circuits and systems最新文献

{"title":"A 402 MHz and 1.73-VCE Resonance Regulating Rectifier with On-Chip Antennas for Bioimplants.","authors":"Guoao Liu, Yuanqi Hu","doi":"10.1109/TBCAS.2024.3523913","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3523913","url":null,"abstract":"<p><p>In this paper, a wireless power transfer (WPT) system composed of a voltage-mode fully integrated resonance regulating rectifier (IR³) and an on-chip antenna running at 402 MHz has been designed for bioimplants in deep tissue. The proposed IR³, including a 200 pF decoupling capacitor, is implemented in a 0.22 mm² active area in the 180-nm CMOS process. A charging duration based regulation compensation circuit offers a low ripple factor of 0.3% at a 1.8 V output voltage and a high voltage conversion efficiency (VCE) of 1.73 to overcome the low inductive coupling coefficient (under 0.01) due to the deep implant scenario. And a clock gating VCDL-based on-&-off delay compensation scheme is proposed to compensate for the phase error of the IR³. Performing rectification and regulation simultaneously in a single stage, the IR³ effectively enhances power conversion efficiency. The whole system achieves a power conversion efficiency (PCE) of 65% with a 1.5 mW load. In addition, digital control-based compensation circuits also improve its transient response performance, the 1% setting time is only 6.9 μs when the load changes from 65 μW to 1.5 mW.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Portable Chip-Based Overhauser DNP Platform for Biomedical Liquid Sample Analysis","authors":"Qing Yang;Hadi Lotfi;Frederik Dreyer;Michal Kern;Bernhard Blümich;Jens Anders","doi":"10.1109/TBCAS.2024.3521033","DOIUrl":"10.1109/TBCAS.2024.3521033","url":null,"abstract":"Low-field nuclear magnetic resonance (NMR) instruments are an indispensable tool in industrial research and quality control. However, the intrinsically low spin polarization at low magnetic fields severely limits their detection sensitivity and measurement throughput, preventing their widespread use in biomedical analysis. Overhauser dynamic nuclear polarization (ODNP) effectively addresses this problem by transferring the spin polarization from free electrons to protons, significantly enhancing sensitivity. In this paper, we explore the potential of using ODNP for signal enhancement in a custom-designed portable chip-based DNP-enhanced NMR platform, which is centered around a miniaturized microwave (MW) transmitter, a custom-designed NMR-on-a-chip transceiver, and two application-specific ODNP probes. The MW transmitter provides frequency synthesis, signal modulation, and power amplification, providing sufficient output power for efficient polarization transfer. The NMR-on-a-chip transceiver combines a radio frequency (RF) transmitter with a fully differential quadrature receiver, providing pulsed excitation and NMR signal down-conversion and amplification. Two custom-designed ODNP probes are used for proof-of-concept DNP-enhanced NMR relaxometry and spectroscopy measurements. The presented chip-based ODNP platform achieves a maximum MW output power of <inline-formula><tex-math>$34 textrm{dBm}$</tex-math></inline-formula>, resulting in a signal enhancement of <inline-formula><tex-math>$-162$</tex-math></inline-formula> using the relaxometry ODNP probe with <inline-formula><tex-math>$1.4 mutextrm{L}$</tex-math></inline-formula> of <inline-formula><tex-math>$10 textrm{mM}$</tex-math></inline-formula> non-degassed TEMPOL solution, and an enhancement of <inline-formula><tex-math>$-63$</tex-math></inline-formula> with the spectroscopy ODNP probe using <inline-formula><tex-math>$50 textrm{nL}$</tex-math></inline-formula> of the same solution. The proton polarization was increased from <inline-formula><tex-math>$0.5times 10^{-6}$</tex-math></inline-formula> to <inline-formula><tex-math>$81times 10^{-6}$</tex-math></inline-formula> at a low field of <inline-formula><tex-math>$0.16 textrm{T}$</tex-math></inline-formula>. Proof-of-concept measurements on radical-doped tattoo inks and acetic acid verify the potential of our chip-based ODNP platform for the analysis of biologically and medically relevant parameters such as relaxation times, chemical shifts, and hyperfine interactions.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 2","pages":"257-269"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Index IEEE Transactions on Biomedical Circuits and Systems Vol. 18","authors":"","doi":"10.1109/TBCAS.2024.3519932","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3519932","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1385-1410"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10810376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 153.4 dB-DR PPG Recording IC with Extended Counting and Hardware Reuse.","authors":"Tingting Wei, Hang Chen, Jiahui Lai, Jinhua Ni, Xiaoyang Zeng, Zhiliang Hong","doi":"10.1109/TBCAS.2024.3517834","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3517834","url":null,"abstract":"<p><p>Photoplethysmogram (PPG) is widely used in wearable devices for health monitoring. High-precision signals are essential for medical diagnostics. However, motion artifacts in these devices can cause significant ambient light variation during PPG recording. This paper presents an accurate PPG recording front end with enhanced ambient light rejection (ALR). Quantization noise in a second-order sigma-delta modulator (SDM), used for direct current conversion, is reduced by extended counting of the modulator's residue. The first integrator of the SDM and the residue analog-to-digital converter (ADC) are reused in ALR circuits. The correlated double sampling (CDS) technique is enhanced by applying a first-order approximation of ambient light. Gain error in the residue ADC is reduced by charge compensation. The PPG front-end, implemented in a 180 nm process, achieves a dynamic range (DR) of 153.4 dB within a bandwidth of 20 Hz. The system operates with a minimum 1.28% duty cycle. Measurements of heart rate and blood oxygen at the fingertip and wrist verify the functionality of the PPG front end.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TechRxiv: Share Your Preprint Research with the World!","authors":"","doi":"10.1109/TBCAS.2024.3511193","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511193","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1382-1382"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blank Page","authors":"","doi":"10.1109/TBCAS.2024.3511176","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511176","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C4-C4"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783941","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IEEE Transactions on Biomedical Circuits and Systems Publication Information","authors":"","doi":"10.1109/TBCAS.2024.3485302","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3485302","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C2-C2"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Together, We are advance technology","authors":"","doi":"10.1109/TBCAS.2024.3511197","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511197","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"1384-1384"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IEEE Circuits and Systems Society Information","authors":"","doi":"10.1109/TBCAS.2024.3511174","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3511174","url":null,"abstract":"","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"18 6","pages":"C3-C3"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10783933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Programmable CMOS DEP Chip for Cell Manipulation.","authors":"Wen-Yue Lin, Lin-Hung Lai, Yi-Wei Lin, Chen-Yi Lee","doi":"10.1109/TBCAS.2024.3514874","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3514874","url":null,"abstract":"<p><p>This work presents a programmable CMOS DEP chip that allows real-time control over the spatial distribution of DEP force, enabling controlled cell movement on the chip surface, from single-cell manipulation to multi-cell patterning. Implemented on a standard 0.18 μm CMOS process without post-processing, the chip features a 128 × 128 array of individually controllable 10 μm microelectrodes with 0.28 μm spacing. Utilizing Metal 5 electrodes in a 1P6M process, the chip achieves particle manipulation speeds up to 27 μm/s while operating at only 1.8 V, preserving cell viability as confirmed through post- DEP assessments. The implementation of time-sharing patterns enhances manipulation precision by creating distinct boundaries between phases. Experiments demonstrate the chip's capabilities in particle patterning, concentration control, and single-particle manipulation, all performed sequentially on the same chip. Additionally, stem cell aggregation control demonstration offers possibilities for future differentiation studies. With its reconfigurability, this DEP chip offers promising solutions to technical challenges in cell preparation, drug screening, and other biological applications.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}