IEEE transactions on biomedical circuits and systems最新文献_第3页

A Cyto-silicon Hybrid System with On-chip Closed-loop Modulation. 具有片上闭环调制功能的细胞硅混合系统

IEEE transactions on biomedical circuits and systems Pub Date : 2024-09-23 DOI: 10.1109/TBCAS.2024.3466549

Jun Wang, Seok Joo Kim, Wenxuan Wu, Jongha Lee, Henry Hinton, Rona S Gertner, Han Sae Jung, Hongkun Park, Donhee Ham

{"title":"A Cyto-silicon Hybrid System with On-chip Closed-loop Modulation.","authors":"Jun Wang, Seok Joo Kim, Wenxuan Wu, Jongha Lee, Henry Hinton, Rona S Gertner, Han Sae Jung, Hongkun Park, Donhee Ham","doi":"10.1109/TBCAS.2024.3466549","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3466549","url":null,"abstract":"We introduce a bioelectronic interface between biological electrogenic cells and a mixed-signal CMOS integrated circuit with an array of surface electrodes, where not only is the CMOS electrode array capable of electrophysiological recording and stimulation of the cells with 1,024 recording and stimulation channels, but it can also provide low-latency artificial signal pathways from cells it records to cells it stimulates. This on-chip closed-loop modulation has an intrinsic latency less than 5 μs. To demonstrate the utility of the on-chip closed loop modulation as an artificial feedback pathway between biological cells, we develop a silicon-cardiomyocyte self-sustained oscillator with a tunable frequency to which both the relevant part of the CMOS chip and cells are locked, and also a silicon-neuron interface with a silicon inhibitory connection between neuronal cells. This line of cyto-silicon hybrid system, where the boundary between biological and semiconductor systems is blurred, may find applications in prosthesis, brain-machine interface, and fundamental biology research.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Implementation of Integrated Dual-Mode Pulse and Continuous-Wave Electron Paramagnetic Resonance Spectrometers. 集成双模脉冲和连续波电子顺磁共振频谱仪的设计与实现。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-09-20 DOI: 10.1109/TBCAS.2024.3465210

Jui-Hung Sun, Difei Wu, Peter Qin, Constantine Sideris

{"title":"Design and Implementation of Integrated Dual-Mode Pulse and Continuous-Wave Electron Paramagnetic Resonance Spectrometers.","authors":"Jui-Hung Sun, Difei Wu, Peter Qin, Constantine Sideris","doi":"10.1109/TBCAS.2024.3465210","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3465210","url":null,"abstract":"Electron paramagnetic resonance (EPR) is a powerful spectroscopic technique that allows direct detection and characterization of radicals containing unpaired electron(s). The development of portable, low-power EPR sensing modalities has the potential to significantly expand the utility of EPR in a broad range of fields, ranging from basic science to practical applications such as point-of-care diagnostics. The two major methodologies of EPR are continuous-wave (CW) EPR, where the frequency or field is swept with a constant excitation, and pulse EPR, where short pulses induce a transient signal. In this work, we present the first realization of a fully integrated pulse EPR spectrometer on-chip. The spectrometer utilizes a subharmonic direct-conversion architecture that enables an on-chip oscillator to be used as a dual-mode EPR sensing cell, capable of both CW and pulse-mode operation. An on-chip reference oscillator is used to injection-lock the sensor to form pulses and also to downconvert the pulse EPR signal. A proof-of-concept spectrometer IC with two independent sensing cells is presented, which achieves a pulse sensitivity of 4.6 x 109 spins (1000 averages) and a CW sensitivity of 2.9 x 109 spins/ √{Hz} and can be powered and controlled via a computer USB interface. The sensing cells consume as little as 2.1mW (CW mode), and the system is tunable over a wide frequency range of 12.8-14.9GHz (CW/pulse). Single-pulse free induction decay (FID), two-pulse inversion recovery, two-pulse Hahn echo, three-pulse stimulated echo, and CW experiments demonstrate the viability of the spectrometer for use in portable EPR sensing.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEXUS: A 28nm 3.3pJ/SOP 16-Core Spiking Neural Network with a Diamond Topology for Real-Time Data Processing. NEXUS：用于实时数据处理的 28 纳米 3.3pJ/SOP 16 核钻石拓扑尖峰神经网络。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-30 DOI: 10.1109/TBCAS.2024.3452635

Maryam Sadeghi, Yasser Rezaeiyan, Dario Fernandez Khatiboun, Sherif Eissa, Federico Corradi, Charles Augustine, Farshad Moradi

{"title":"NEXUS: A 28nm 3.3pJ/SOP 16-Core Spiking Neural Network with a Diamond Topology for Real-Time Data Processing.","authors":"Maryam Sadeghi, Yasser Rezaeiyan, Dario Fernandez Khatiboun, Sherif Eissa, Federico Corradi, Charles Augustine, Farshad Moradi","doi":"10.1109/TBCAS.2024.3452635","DOIUrl":"10.1109/TBCAS.2024.3452635","url":null,"abstract":"The realization of brain-scale spiking neural networks (SNNs) is impeded by power constraints and low integration density. To address these challenges, multi-core SNNs are utilized to emulate numerous neurons with high energy efficiency, where spike packets are routed through a network-on-chip (NoC). However, the information can be lost in the NoC under high spike traffic conditions, leading to performance degradation. This work presents NEXUS, a 16-core SNN with a diamond-shaped NoC topology fabricated in 28-nm CMOS technology. It integrates 4096 leaky integrate-and-fire (LIF) neurons with 1M 4-bit synaptic weights, occupying an area of 2.16 mm2. The proposed NoC architecture is scalable to any network size, ensuring no data loss due to contending packets with a maximum routing latency of 5.1μs for 16 cores. The proposed congestion management method eliminates the need for FIFO in routers, resulting in a compact router footprint of 0.001 mm2. The proposed neurosynaptic core allows for increasing the processing speed by up to 8.5× depending on input sparsity. The SNN achieves a peak throughput of 4.7 GSOP/s at 0.9 V, consuming a minimum energy per synaptic operation (SOP) of 3.3 pJ at 0.55 V. A 4-layer feed-forward network is mapped onto the chip, classifying MNIST digits with 92.3% accuracy at 8.4Kclassification/ s and consuming 2.7-μJ/classification. Additionally, an audio recognition task mapped onto the chip achieves 87.4% accuracy at 215-μJ/classification.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GCOC: A Genome Classifier-On-Chip based on Similarity Search Content Addressable Memory. GCOC：基于相似性搜索内容可寻址内存的片上基因组分类器。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-28 DOI: 10.1109/TBCAS.2024.3449788

Yuval Harary, Paz Snapir, Shir Siman Tov, Chen Kruphman, Eyal Rechef, Zuher Jahshan, Esteban Garzon, Leonid Yavits

{"title":"GCOC: A Genome Classifier-On-Chip based on Similarity Search Content Addressable Memory.","authors":"Yuval Harary, Paz Snapir, Shir Siman Tov, Chen Kruphman, Eyal Rechef, Zuher Jahshan, Esteban Garzon, Leonid Yavits","doi":"10.1109/TBCAS.2024.3449788","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3449788","url":null,"abstract":"GCOC is a genome classification system-on-chip (SoC) that classifies genomes by k-mer matching, an approach that divides a DNA query sequence into a set of short DNA fragments of size k, which are searched in a reference genome database, with the underlying assumption that sequenced DNA reads of the same organism (or its close variants) share most of such k-mers. At the core of GCOC is a similarity, or approximate search-capable Content Addressable Memory (SAS-CAM), which in addition to exact match, also supports approximate, or Hamming distance tolerant search. Classification operation is controlled by an embedded RISC-V processor. GCOC classification platform was designed and manufactured in a commercial 65nm process. We conduct a thorough analysis of GCOC classification efficiency as well as its performance, silicon area, and power consumption using silicon measurements. GCOC classifies 769.2K short DNA reads/sec. The silicon area of GCOC SoC is 3.12mm2 and its power consumption is 1.27mW. We envision GCOC deployed as a field (for example at points of care) portable classifier where the classification is required to be real-time, easy to operate and energy efficient.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Electrochemical CMOS Biosensor Array Using Phase-Only Modulation With 0.035% Phase Error And In-Pixel Averaging. 使用相位误差为 0.035% 的纯相位调制和像素内平均的电化学 CMOS 生物传感器阵列

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-28 DOI: 10.1109/TBCAS.2024.3450843

Aditi Jain, Saeromi Chung, Eliah Aronoff Spencer, Drew A Hall

引用次数: 0

Low-Power and Low-Cost AI Processor with Distributed-Aggregated Classification Architecture for Wearable Epilepsy Seizure Detection. 采用分布式聚合分类架构的低功耗、低成本人工智能处理器，用于可穿戴式癫痫发作检测。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-28 DOI: 10.1109/TBCAS.2024.3450896

Qiang Zhang, Mingyue Cui, Yue Liu, Weichong Chen, Zhiyi Yu

{"title":"Low-Power and Low-Cost AI Processor with Distributed-Aggregated Classification Architecture for Wearable Epilepsy Seizure Detection.","authors":"Qiang Zhang, Mingyue Cui, Yue Liu, Weichong Chen, Zhiyi Yu","doi":"10.1109/TBCAS.2024.3450896","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3450896","url":null,"abstract":"Wearable devices with continuous monitoring capabilities are critical for the daily detection of epileptic seizures, as they provide users with accurate and comprehensible analytical results. However, current AI classifiers rely on a two-stage recognition process for continuous monitoring, which only reduces operation time but remains challenged by the high cost of additional hardware. To address this problem, this article proposes a novel fusion architecture for AI processors, which enables event-triggered cross-paradigm integration and computation. Our method introduces a distributed-aggregated classification architecture (D-ACA) that facilitates the reuse of hardware resources across two-stage recognition, thereby obviating the need for standby hardware and enhancing energy efficiency. Integrating a non-encoding biomedical circuit method based on spiking neural networks (SNNs), the architecture eliminates encoded neurons at the hardware level, significantly optimizing energy consumption and hardware resource utilization. Additionally, we develop a configurable and highly flexible control method that supports various neuron modules, enabling continuous detection of epileptic seizures and activating high-precision recognition upon event detection. Finally, we implement the design on the Xilinx ZCU 102 FPGA board, where the AI processor achieves a high classification accuracy of 98.1% while consuming extremely low classification energy (3.73 μJ per classification).","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parallel Resonant Magnetic Field Generator for Biomedical Applications. 用于生物医学应用的并联谐振磁场发生器。

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-28 DOI: 10.1109/TBCAS.2024.3450881

Yuan Lei, Shoulong Dong, Runze Liang, Sizhe Xiang, Qinyu Huang, Junhao Ma, Hongyu Kou, Liang Yu, Chenguo Yao

{"title":"Parallel Resonant Magnetic Field Generator for Biomedical Applications.","authors":"Yuan Lei, Shoulong Dong, Runze Liang, Sizhe Xiang, Qinyu Huang, Junhao Ma, Hongyu Kou, Liang Yu, Chenguo Yao","doi":"10.1109/TBCAS.2024.3450881","DOIUrl":"https://doi.org/10.1109/TBCAS.2024.3450881","url":null,"abstract":"In recent years, pulsed magnetic field (PMF) have attracted significant attention as a non-invasive electroporation method in the biomedical field. To further explore the biomedical effects generated by oscillating PMF, we designed a novel PMF generator for biomedical research. Based on resonance principles, the designed generator outputs sinusoidal oscillating PMF. To validate the feasibility and application value of the designed topology, a miniaturized platform was constructed using a selected multi-turn solenoid coil. The output performance of the generator was tested under different discharge voltage levels. The results revealed that the current multiplication factor remained consistently around 2 times, with the energy efficiency and circuit quality factor maintained at 82% and above 4.5, respectively. In addition, the generator's ability to flexibly modulate the number of pulse oscillations was demonstrated. The compatibility of the designed coil parameters and generator circuit parameters was analyzed, with tests on the effects of coil resistance and switch action time on the generator's output performance. Based on the magnetic field action platform, a simulation model of the actual scale coil was established. The spatial and temporal distribution of the magnetic field, induced electric field, and power transmission in the target area were described from multiple angles. Finally, biological experiments conducted using the constructed generator revealed the synergistic effect of sinusoidal oscillating PMF combined with drugs in tumor cell killing.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blank Page 空白页

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-21 DOI: 10.1109/TBCAS.2024.3437556

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IEEE Transactions on Biomedical Circuits and Systems Publication Information IEEE 生物医学电路与系统论文集》出版信息

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-21 DOI: 10.1109/TBCAS.2024.3437552

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Guest Editorial: Special Issue on Selected Articles From IEEE BioCAS 2023 特邀编辑：IEEE BioCAS 2023 文章选编特刊

IEEE transactions on biomedical circuits and systems Pub Date : 2024-08-21 DOI: 10.1109/TBCAS.2024.3434009

Chung-Chih Hung;Mohamed Atef;Vanessa Chen

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