IEEE transactions on biomedical circuits and systems最新文献_第2页

IEEE Transactions on Biomedical Circuits and Systems Publication Information IEEE生物医学电路和系统汇刊信息

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-08-05 DOI: 10.1109/TBCAS.2025.3576469

引用次数: 0

Erratum to “A 43.5dB Gain Unipolar a-IGZO TFT Amplifier with Parallel Bootstrap Capacitor for Bio-signals Sensing Applications” “用于生物信号传感应用的带并联自引导电容的43.5dB增益单极A - igzo TFT放大器”的校误

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-08-05 DOI: 10.1109/TBCAS.2025.3583095

Mingjian Zhao;Laiqing Li;Rui Liu;Bin Li;Rongsheng Chen;Zhaohui Wu

引用次数: 0

A Fast Electrochemical Impedance Spectroscopy With a Square Wave as Excitation Signal for Impedance-Based Biomedical Applications. 基于阻抗的生物医学应用中以方波为激励信号的快速电化学阻抗谱。

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-08-01 DOI: 10.1109/TBCAS.2025.3579698

Zhongzheng Wang, Han Shao, Alan O'Riordan, Javier Higes-Marquez, Ivan O'Connell, Daniel O'Hare

{"title":"A Fast Electrochemical Impedance Spectroscopy With a Square Wave as Excitation Signal for Impedance-Based Biomedical Applications.","authors":"Zhongzheng Wang, Han Shao, Alan O'Riordan, Javier Higes-Marquez, Ivan O'Connell, Daniel O'Hare","doi":"10.1109/TBCAS.2025.3579698","DOIUrl":"10.1109/TBCAS.2025.3579698","url":null,"abstract":"This paper introduces a fast, high-accuracy methodology for conducting Electrochemical Impedance Spectroscopy (EIS) based on Fast Fourier Transform (FFT), to meet the requirements of portable, real-time biomedical impedance-based detections with Ultra-Microband (UMB) sensor. Instead of using white noise-like wideband signals as in conventional FFT-based EIS, the proposed method uses a square wave as the excitation signal, which achieves a fast, accurate EIS measurement, but no longer requires complex circuits like high-resolution DACs or frequency mixers for the signal generation. This work starts with the theoretical justification for treating the sensor as a Linear Time-Invariant (LTI), then the practical linear region for operating the sensor as an LTI system is experimentally verified and determined, which enables the capacity of employing the harmonics of a square wave for EIS measurements. A dynamic model of the charge-transfer resistance together with an approximated of the Constant Phase Element (CPE) are implemented with Verilog-A for simulations, and a circuit consisting of a control amplifier and a Trans-Impedance Amplifier (TIA) is designed and fabricated with 65 nm CMOS for validating its on-chip feasibility. This work shortens the EIS measurement time by 91.7% in a frequency sweep range from 0.5 Hz to 500 Hz, with only 2.73% average Mean Absolute Percentage Error (MAPE), compared to a commercial electrochemical instrument AutoLab, with five pre-modified electrodes across four different concentrations of Ferrocene Carboxylic Acid (FcCOOH), demonstrating this method is suitable for portable, real-time label-free EIS biomedical detections and applications.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":"726-742"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FPGA-based Medical Image Processing Using Hardware-Software Co-design Approach. 基于fpga的医学图像处理软硬件协同设计方法。

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-08-01 DOI: 10.1109/TBCAS.2025.3594840

Abhishek Yadav, Vyom Kumar Gupta, Binod Kumar

{"title":"FPGA-based Medical Image Processing Using Hardware-Software Co-design Approach.","authors":"Abhishek Yadav, Vyom Kumar Gupta, Binod Kumar","doi":"10.1109/TBCAS.2025.3594840","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3594840","url":null,"abstract":"This paper presents a field-programmable gate array (FPGA) based medical image processing framework using a hardware-software co-design approach for biomedical tasks such as Malaria and Pneumonia detection. The design is implemented on the AMD-Xilinx UltraScale+ MPSoC (ZCU104) FPGA, focusing on optimizing data movement between the Processing System (PS) and Programmable Logic (PL) through a customized high-level synthesis (HLS) process. Depth-wise convolution is employed to reduce computational complexity, while layer fusion is applied to optimize layer-wise execution, and custom cache is integrated to improve memory access efficiency. The accelerated architecture is integrated with AXI interconnects and tested using the PYNQ overlay process. The experimental results demonstrate that the proposed accelerator achieves a throughput of 298.22 FPS and 205.87 FPS for the detection of malaria and pneumonia, respectively. The proposed design significantly improves energy efficiency, consuming 14.62 mJ/img for the detection of malaria and 23.89 mJ/img for the detection of pneumonia. Compared to alternative hardware platforms like Raspberry Pi with Coral TPU, the FPGA-based implementation offers superior performance, achieving 8.3× higher throughput and 4.3× better energy efficiency, making it well-suited for real-time medical image processing applications.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MulPi: A Multi-class and Patient-Independent Epileptic Seizure Classifier With Co-Designed Input-stationary Computing-in-SRAM. MulPi：一种多类别、独立于患者的癫痫发作分类器，在sram中协同设计输入静止计算。

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-08-01 DOI: 10.1109/TBCAS.2025.3579273

Bokyung Kim, Qijia Huang, Brady Taylor, Qilin Zheng, Jonathan Ku, Yiran Chen, Hai Li

{"title":"MulPi: A Multi-class and Patient-Independent Epileptic Seizure Classifier With Co-Designed Input-stationary Computing-in-SRAM.","authors":"Bokyung Kim, Qijia Huang, Brady Taylor, Qilin Zheng, Jonathan Ku, Yiran Chen, Hai Li","doi":"10.1109/TBCAS.2025.3579273","DOIUrl":"10.1109/TBCAS.2025.3579273","url":null,"abstract":"Unprovoked seizures have threatened epilepsy patients over 70 million. Automated classification to detect and predict seizures could bring seizure-free lives to epilepsy patients, delivering them from fatal danger and increasing the quality of life. Authentic detection and prediction of seizures require 1) multi-class (Mul) and 2) patient-independent (Pi) classification. Recent implementable chips for seizure classification rarely satisfy the two requirements due to restricted resources in small chips; therefore, high efficiency is imperative along with accuracy. This paper introduces an efficient MulPi chip, fabricated for the first time to simultaneously fulfill multi-class and patient independence, based on a co-design approach. We develop a 5-layer convolutional neural network (CNN), MulPiCNN, with advanced training techniques for lightness and accuracy. At the hardware level, our SRAM-based chip leverages computing-in-memory (CIM) for efficiency. The fabricated MulPi chip is distinguished from prior CIMs in two folds, namely ISRW-CIM: a) input-stationary (IS) CIM for resource-saving, and b) row-wise (RW) computing to address a challenge of SRAM CIM, empowered by our novel 2T-Hadamard product unit (HPU). MulPi outperforms state-of-the-art chips with 98.5% sensitivity and 99.2% specificity, classifying in 0.12s and 0.348mm${}^{2}$.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":"756-766"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 40.68-MHz Fully-Integrated Voltage/Current-Mode Dual-Output PMU for Wireless Neural Implants. 用于无线神经植入物的40.68 mhz全集成电压/电流模式双输出PMU。

IEEE transactions on biomedical circuits and systems Pub Date : 2025-07-22 DOI: 10.1109/TBCAS.2025.3591228

Yi-Han Ou-Yang, Ronald Wijermars, Pyungwoo Yeon, Tianqi Lu, Amin Arbabian, Wouter A Serdijn, Sijun Du, Dante G Muratore

{"title":"A 40.68-MHz Fully-Integrated Voltage/Current-Mode Dual-Output PMU for Wireless Neural Implants.","authors":"Yi-Han Ou-Yang, Ronald Wijermars, Pyungwoo Yeon, Tianqi Lu, Amin Arbabian, Wouter A Serdijn, Sijun Du, Dante G Muratore","doi":"10.1109/TBCAS.2025.3591228","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3591228","url":null,"abstract":"This paper presents a fully-integrated single-input dual-output power management unit operating both in voltage/ current modes for powering mm-scale wireless neural implants. The chip operates in voltage mode most of the time, using an active full-wave rectifier to regulate a low-voltage, high-load output with high power efficiency and low output ripple (<32 mVpp). It switches to current mode rectification when generating a high-voltage, low-load output. This dual-mode operation allows for flexible power distribution and configurable voltage ratios between the two outputs. The selected 40.68 MHz operating frequency reduces the required capacitances for input impedance matching and output filtering, enabling on-chip integration; the only external component is the receiver coil. A novel resonance breakup switch compatible with full-wave rectification ensures a smooth cold start-up of the chip without any external voltage supply. The chip was fabricated using 40-nm CMOS technology with an active area of 1.18 mm2and was tested in a wireless power link. Measurement results demonstrate that the chip can simultaneously regulate two outputs, $V_{LV} = text{1 V}$ and $V_{HV} = text{2 V}$, with a tested maximum output power of 10 mW and 32.6 μW on $V_{LV}$ and $V_{HV}$ , respectively. At the optimal output power condition $(P_{LV} = 4.4 sim 6.7, text{mW})$, the system achieves a peak power conversion efficiency of 85.87% and a peak end-to-end efficiency of 17.32% when regulating $V_{LV}$. The end-to-end efficiency drops by only 2.38% when regulating both outputs with $R_{LV} = 225 Omega$ and $R_{HV} = 400 ,text{k}Omega$.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Stimulus Artifact Suppression System With Fast Template Subtraction 一种新的快速模板减法刺激伪影抑制系统。

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-07-22 DOI: 10.1109/TBCAS.2025.3591110

Yirui Liu;Quanbei Chang;Xuhui Li;Xiao Liu

{"title":"A Novel Stimulus Artifact Suppression System With Fast Template Subtraction","authors":"Yirui Liu;Quanbei Chang;Xuhui Li;Xiao Liu","doi":"10.1109/TBCAS.2025.3591110","DOIUrl":"10.1109/TBCAS.2025.3591110","url":null,"abstract":"The presence of large stimulus artifact (SA) makes it difficult to perform concurrent stimulation and recording in retinal prostheses. This paper presents a novel template-based system for suppressing SA visible at the stimulation/recording electrodes. The template of SA has been derived by working out the full <italic>Randles impedance model whose expression in the frequency domain serves as the transfer function from the stimulus current to SA. A prototype ASIC has been fabricated in a 180-nm CMOS process and validated in saline. The template calculation framework utilizes a pipeline digital processing which achieves rapid template generation within 26.35 ms (25.6 ms for acquiring the SA waveform and 0.75 ms for computation) after the detection of the first stimulation phase. The real-time SA suppression is 20.2 dB and can be boosted to 44.3 dB with offline signal processing. The ASIC’s core occupies 0.43 mm2. It consumes 8.27 <inline-formula><tex-math>$mu$</tex-math></inline-formula>W and 30.83 <inline-formula><tex-math>$mu$</tex-math></inline-formula>W in the normal amplification mode and SA suppression mode, respectively.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 5","pages":"936-949"},"PeriodicalIF":4.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Challenges in Integrated Circuits for Electrochemical Sensing: Enabling Next-Generation Biomedical and Molecular Applications 电化学传感集成电路的进展与挑战：实现下一代生物医学和分子应用。

IF 4.9

IEEE transactions on biomedical circuits and systems Pub Date : 2025-07-14 DOI: 10.1109/TBCAS.2025.3589027

Qiuyang Lin;Sander Crols;Aurojyoti Das;Marcel Zevenbergen;Wim Sijbers;Nick Van Helleputte;Carolina Mora Lopez

{"title":"Advances and Challenges in Integrated Circuits for Electrochemical Sensing: Enabling Next-Generation Biomedical and Molecular Applications","authors":"Qiuyang Lin;Sander Crols;Aurojyoti Das;Marcel Zevenbergen;Wim Sijbers;Nick Van Helleputte;Carolina Mora Lopez","doi":"10.1109/TBCAS.2025.3589027","DOIUrl":"10.1109/TBCAS.2025.3589027","url":null,"abstract":"This manuscript provides a comprehensive review of the design, implementation, and advancements in integrated circuits (ICs) for electrochemical sensing, with a focus on biomedical and molecular applications. It begins by discussing the fundamental principles of electrochemical sensing and core modalities, including potentiometry, amperometry, impedimetry, and ISFET-based sensing, highlighting their unique requirements and challenges. A detailed analysis of state-of-the-art readout circuit architectures is presented, emphasizing strategies for achieving high dynamic range (DR), low noise, and enhanced stability while minimizing leakage currents. Both resistive and capacitive transimpedance amplifiers (TIAs) and current conveyor (CC)-based circuits are examined, exploring critical trade-offs between speed, power consumption, and noise performance. This review also discusses emerging applications such as DNA sequencing and molecular sensing, covering both ISFET and nanopore-based approaches, to showcase recent advancements in high-throughput, high-speed, and low-power interface circuit designs. By highlighting the challenges of the readout-circuit miniaturization, integration, and scalability, as well as the current limitations in existing approaches, this review provides a comprehensive synthesis of advancements in high-performance electrochemical readout architectures and their potential to address the evolving demands of modern biomedical applications.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"19 5","pages":"876-896"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fully-Integrated 0.068-mm³ Implantable Pressure Sensing Device with Wireless Energy Harvesting and Data Telemetry. 具有无线能量收集和数据遥测功能的完全集成的0.068毫米3植入式压力传感装置。

IEEE transactions on biomedical circuits and systems Pub Date : 2025-07-04 DOI: 10.1109/TBCAS.2025.3586009

Zehua Lan, Jiahua Shi, Jiayue Hao, Zhihua Wang, Yanshu Guo, Hanjun Jiang

{"title":"A Fully-Integrated 0.068-mm3 Implantable Pressure Sensing Device with Wireless Energy Harvesting and Data Telemetry.","authors":"Zehua Lan, Jiahua Shi, Jiayue Hao, Zhihua Wang, Yanshu Guo, Hanjun Jiang","doi":"10.1109/TBCAS.2025.3586009","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3586009","url":null,"abstract":"This paper reports a fully-integrated sub-0.1 mm3 wireless pressure sensing device for implantable applications. The miniature device integrates a customized system-on-a-chip (SoC) and an off-the-shelf half-bridge piezoresistive pressure transducer, eliminating off-chip passive components. The SoC mainly comprises a resistance-to-time converter, a 915 MHz inductively coupled energy harvester with an on-chip coil, and a backscatter telemetry. Key innovations enabling low power, small size and high precision include: (1) A source-input common-gate amplifier based R-V converter, that reuses the transducer's bias current, (2) advanced noise management via chopper stabilization and supply noise cancellation, and (3) A compact high-Q on-chip multi-layer stacked coil design for wireless link. The active circuits consume 9.75 μW power, which is fully supplied by the energy harvested wirelessly through the on-chip coil. The sensing data is transmitted wirelessly to an external recorder through the RF backscatter link. Fabricated in a 65-nm CMOS technology, the SoC occupies a die area of 400 μm × 490 μm, and the entire fully-integrated sensor has a volume of only 0.068 mm3, enabling syringe injection through a ≤0.5 mm needle. Experiments with the sensing device covered by pork have demonstrated that the device can operate at an implant depth of up to 10 mm with excellent misalignment tolerance. It offers a pressure sensing resolution of 3.1 mmHg over a relative pressure range of 0-200 mmHg and a temperature sensing resolution of 0.18°C.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Differential Impedance Flow Cytometry Front-End with Baseline Current Cancellation. 差分阻抗流式细胞仪前端与基线电流消除。

IEEE transactions on biomedical circuits and systems Pub Date : 2025-07-01 DOI: 10.1109/TBCAS.2025.3585089

Siyuan Yu, Louis Marun, Matthew L Johnston

{"title":"A Differential Impedance Flow Cytometry Front-End with Baseline Current Cancellation.","authors":"Siyuan Yu, Louis Marun, Matthew L Johnston","doi":"10.1109/TBCAS.2025.3585089","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3585089","url":null,"abstract":"In this work, we present a high-performance analog front-end (AFE) circuit for impedance-based flow cytometry readout. The AFE is designed to interface to a three-electrode sensor topology using center electrode excitation and differential current output. To satisfy the needs of a differential high gain signal path, we propose a digitally tunable and calibrated cancellation current generation path to remove the baseline current injected into the transimpedance amplifier (TIA) stages. This prevents TIA saturation and allows for higher gain. Consequently, the AFE is more power efficient while maintaining better noise and interference rejection. The proposed circuit is designed and fabricated in a 180nm CMOS process. It covers an excitation frequency range of 0.5MHz to 10MHz and consumes 15.6mW during nominal operation. Digital calibration is implemented using an off-chip ADC and automated calibration algorithm. Measurement results show that at 1MHz excitation, the AFE achieves $1.7 text{pA}/sqrt{text{Hz}}$ input-referred current noise density with floating inputs. The AFE achieves detection of 3um diameter particles in a microfluidic flow cell, demonstrating its performance and practicality for impedance flow cytometry.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0