Mannhee Cho, Minil Kang, Minseong Um, Hangue Park, Hyung-Min Lee
{"title":"CMOS LIF Neurons with Local Membrane Dynamic Biasing Based on Reciprocal Inhibition for Self-Oscillatory Neural Networks.","authors":"Mannhee Cho, Minil Kang, Minseong Um, Hangue Park, Hyung-Min Lee","doi":"10.1109/TBCAS.2025.3583093","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3583093","url":null,"abstract":"<p><p>This paper presents a CMOS-based neuron network that can emulate self-oscillatory biasing behaviors found in biological neural oscillator models. Based on leaky integrate-and-fire (LIF) neuron models, the proposed neuron circuit adopts the concept of reciprocal inhibitory network and synaptic fatigue as well as excitatory drive stimulation for replicating extracellular fluidic biasing of membrane potentials. On top of the base neuron circuit, an excitation integrator integrates positive and negative excitatory input spikes to stimulate the membrane potential bias, and a bias controller receives inhibitory drive input and generates output inhibitory drives depending on the membrane potential bias level. The proposed networks of multiple neurons with inhibitory connections can generate oscillating membrane potential biases, which can be used as local dynamic thresholds for neuron spike firing, resulting in self-patterned output spikes such as switching or dynamic firing rate patterns. The proposed neuron network was implemented with 250-nm CMOS process operating at the supply voltage of 2.5 V and consuming average power of 99.31μW per neuron during full operation. Operation waveforms were measured in various input conditions which can produce multiple output patterns. Variances in output signals due to process variation were measured from 32 neurons to verify the stability of operation, showing the standard deviation of 18% in the membrane potential gain per input spike and 12% in oscillation periods of the membrane potential bias. The results verified that the proposed neuron network can replicate the self-oscillatory behaviors of biological neuron models.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 0.66-mm<sup>2</sup> 0.49 pJ/SOP SNN Processor with Temporal-Spatial Post-Neuron-Processing and Model-Adaptive Crossbar in 40-nm CMOS.","authors":"Jinqiao Yang, Zikai Zhu, Haoming Chu, Anqin Xiao, Yuxiang Huan, Lirong Zheng, Zhuo Zou","doi":"10.1109/TBCAS.2025.3582246","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3582246","url":null,"abstract":"<p><p>This paper presents a Spiking Neural Network (SNN) processor specifically designed to overcome the limitations of existing parallel architectures in maintaining high energy efficiency and model adaptability in a compact area footprint for Artificial Intelligence of Things (AIoT). This is achieved through two key design features: a Temporal-Spatial Post-Neuron Processing (PoNP) scheme that efficiently reuses membrane potential, maximizes parallelism, and reduces memory bank requirements; and a Model-Adaptive Crossbar design with preconfigured parameters and a dynamic switching mechanism enables processing of various SNN models through operation orchestration without efficiency degradation. Using an 8-way parallel pipeline design, the processor achieves a throughput of 128 Synaptic Operations (SOPs) per cycle, resulting in a 2.8× enhancement in energy efficiency. Fabricated in a 40-nm CMOS process, the chip occupies a compact core area of 0.66 mm<sup>2</sup>. It achieves a power consumption of 6.26 mW, an energy efficiency of 0.49 pJ/SOP, and a throughput of 12.8 GSOPS/s at 0.75 V, 100 MHz. The chip is evaluated using typical spatial, temporal, and temporal-spatial datasets, including MIT-BIH, MNIST, N-MNIST, NavGesture, and SHD. These results demonstrate that our chip achieves best-in-class in terms of energy efficiency and latency compared to state-of-the-art architectures.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulating 3D Magnetic Flux Density for Stable Wireless Power Transfer in a Compact Planar Charger for Capsule Endoscopy.","authors":"Heng Zhang, Zheng Li, Chi-Kwan Lee","doi":"10.1109/TBCAS.2025.3581526","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3581526","url":null,"abstract":"<p><p>Wireless charging for small electronic devices remains a significant challenge, especially for applications that demand high-performance operation, such as wearable electronics and medical devices. Many compact devices, including smart-watches and capsule endoscopes, often suffer from limited battery life and frequent recharging requirements. To address these issues, this paper proposes a compact, planar, omnidirectional wireless power transmitter implemented on a multilayer printed circuit board. The proposed design achieves stable wireless charging across varying positions and orientations while maintaining a portable form factor that enables convenient use in diverse settings. To mitigate control challenges arising from overlapping transmitter coils in the planar configuration, a current source inverter is integrated with an LCCL compensation network. Comprehensive mathematical modeling is developed to provide design insights, and the system performance is further validated through computer simulations. In addition, we propose a robust wireless charging algorithm that maintains stable performance under arbitrary spatial positions and orientations, as evidenced by experimental tests demonstrating a mean receiving current fluctuation of only 2.16 mA. Moreover, in capsule endoscopy scenarios, the system achieved an effective charging performance with a maximum transmission power of 1904.4 mW, underscoring its competitiveness with current state-of-the-art designs.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhongzheng Wang, Han Shao, Alan O Riordan, Javier Higes-Marquez, Ivan O Connell, Daniel O Hare
{"title":"A Fast Electrochemical Impedance Spectroscopy with A Square Wave as Excitation Signal for Impedance-based Biomedical Applications.","authors":"Zhongzheng Wang, Han Shao, Alan O Riordan, Javier Higes-Marquez, Ivan O Connell, Daniel O Hare","doi":"10.1109/TBCAS.2025.3579698","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3579698","url":null,"abstract":"<p><p>This paper introduces a fast, high-accuracy methodology for conducting Electrochemical Impedance Spectroscopy (EIS) based on Fast Fourier Transform (FFT), to meet the requirements of portable, real-time biomedical impedance-based detections with Ultra-Microband (UMB) sensor. Instead of using white noise-like wideband signals as in conventional FFT-based EIS, the proposed method uses a square wave as the excitation signal, which achieves a fast, accurate EIS measurement, but no longer requires complex circuits like high-resolution DACs or frequency mixers for the signal generation. This work starts with the theoretical justification for treating the sensor as a Linear Time-Invariant (LTI), then the practical linear region for operating the sensor as an LTI system is experimentally verified and determined, which enables the capacity of employing the harmonics of a square wave for EIS measurements. A dynamic model of the charge-transfer resistance together with an approximated of the Constant Phase Element (CPE) are implemented with Verilog-A for simulations, and a circuit consisting of a control amplifier and a Trans-Impedance Amplifier (TIA) is designed and fabricated with 65 nm CMOS for validating its on-chip feasibility. This work shortens the EIS measurement time by 91.7% in a frequency sweep range from 0.5 Hz to 500 Hz, with only 2.73% average Mean Absolute Percentage Error (MAPE), compared to a commercial electrochemical instrument AutoLab, with five pre-modified electrodes across four different concentrations of Ferrocene Carboxylic Acid (FcCOOH), demonstrating this method is suitable for portable, real-time label-free EIS biomedical detections and applications.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bokyung Kim, Qijia Huang, Brady Taylor, Qilin Zheng, Jonathan Ku, Yiran Chen, Hai Li
{"title":"MulPi: A Multi-class and Patient-independent Epileptic Seizure Classifier with Co-designed Input-stationary Computing-in-SRAM.","authors":"Bokyung Kim, Qijia Huang, Brady Taylor, Qilin Zheng, Jonathan Ku, Yiran Chen, Hai Li","doi":"10.1109/TBCAS.2025.3579273","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3579273","url":null,"abstract":"<p><p>Unprovoked seizures have threatened epilepsy patients over 70 million. Automated classification to detect and predict seizures could bring seizure-free lives to epilepsy patients, delivering them from fatal danger and increasing the quality of life. Authentic detection and prediction of seizures require 1) multi-class (Mul) and 2) patient-independent (Pi) classification. Recent implementable chips for seizure classification rarely satisfy the two requirements due to restricted resources in small chips; therefore, high efficiency is imperative along with accuracy. This paper introduces an efficient MulPi chip, fabricated for the first time to simultaneously fulfill multi-class and patient independence, based on a co-design approach. We develop a 5-layer convolutional neural network (CNN), MulPiCNN, with advanced training techniques for lightness and accuracy. At the hardware level, our SRAM-based chip leverages computingin- memory (CIM) for efficiency. The fabricated MulPi chip is distinguished from prior CIMs in two folds, namely ISRW-CIM: a) input-stationary (IS) CIM for resource-saving, and b) rowwise (RW) computing to address a challenge of SRAM CIM, empowered by our novel 2T-Hadamard product unit (HPU). MulPi outperforms state-of-the-art chips with 98.5% sensitivity and 99.2% specificity, classifying in 0.12s and 0.348mm<sup>2</sup>.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manhyuck Choi, Byeongseol Kim, Sangmin Lee, Kyounghwan Kim, Mookyoung Yoo, Jihyang Wi, Gibae Nam, Minhyeok Son, Inju Yoo, Joonsung Bae, Hyoungho Ko
{"title":"Implantable Cardiovascular Biopotential Acquisition and Stimulation Circuit with Body-Channel Communication for Transcatheter Leadless Pacemaker.","authors":"Manhyuck Choi, Byeongseol Kim, Sangmin Lee, Kyounghwan Kim, Mookyoung Yoo, Jihyang Wi, Gibae Nam, Minhyeok Son, Inju Yoo, Joonsung Bae, Hyoungho Ko","doi":"10.1109/TBCAS.2025.3579065","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3579065","url":null,"abstract":"<p><p>This paper presents an implantable cardiovascular biopotential acquisition and stimulation circuit with body-channel (BC) data communication and power transfer capabilities for a transcatheter leadless pacemaker. The power and size requirements of leadless pacemakers, specifically for implantable electronics and minimally-invasive transcatheter delivery, are highly challenging. To reduce size, electrocardiogram (ECG) sensing, pacing, timing and control logic, and body- coupled wireless transceivers are integrated into a single chip. The ECG sensing channel is designed using a current-reused current-feedback instrumentation amplifier to reduce power consumption. The pacing circuit is implemented using a switched-capacitor stimulator with passive discharge for high stimulation efficiency. The pacemaker utilizes BC communication instead of RF communication to achieve low power consumption. The measured input-referred noise of the sensing channel is 3.69 μV<sub>RMS</sub>, and the power consumption ranges from 4.5 to 19.4 μW. The downlink and uplink speeds of BC communication are 10 Mbps and 16 kbps, respectively. The internal rechargeable battery is properly charged when a 600 mV<sub>PP</sub>, 20 MHz input signal is applied. The leadless pacemaker prototype is implemented with a small size of 5.89 mm and 26.5 mm in diameter and length, respectively. The performance of the leadless pacemaker prototype is evaluated through in vivo experiments using swine.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tzu-Hsuan Chou, Siyuan Yu, Calder Wilson, Jacob Dawes, Jaehyeong Park, Louis Marun, Matthew L Johnston
{"title":"System-on-Chip for Flow Cytometry with Impedance Measurement and Integrated Real-time Size Classification.","authors":"Tzu-Hsuan Chou, Siyuan Yu, Calder Wilson, Jacob Dawes, Jaehyeong Park, Louis Marun, Matthew L Johnston","doi":"10.1109/TBCAS.2025.3576317","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3576317","url":null,"abstract":"<p><p>This paper presents an impedance measurement system-on-chip (SoC) for flow cytometry (i.e. cell counting) applications. A source-differential, three-electrode sensing scheme is used in a microfluidic flow cell for particle detection. At the front-end, a lock-in amplifier architecture is used, including a high-gain TIA with 60MHz bandwidth, passive mixers, and lowpass filters. The ac sensor signal is demodulated to extract inphase (I) and quadrature (Q) baseband components to measure complex impedance. At the back-end, the SoC includes an 8-bit level-crossing ADC (LCADC) for digitizing I/Q signals, followed by real-time digital feature extraction and linear classification for real-time cell size determination. The SoC was fabricated in a 180nm CMOS process. A measured prototype IC achieves 733 fA/$sqrt {Hz}$ noise floor and 23 pArms input-referred noise from 1-1 kHz. Combined with a microfludic flow cell, polymer beads in solution were used as cell surrogates to demonstrate particle counting. Measured results for particle diameters of 10 μm, 6 μm, 4.5 μm and 3 μm are shown. Following offline training, the SoC demonstrated on-chip classification of 4.5 μm and 6 μm beads with a prediction accuracy of 86.16% with pre-recorded data, and 73.6% while performing real-time inline classification.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paola Busia, Gianluca Leone, Andrea Matticola, Luigi Raffo, Paolo Meloni
{"title":"Wearable Epilepsy Seizure Detection on FPGA with Spiking Neural Networks.","authors":"Paola Busia, Gianluca Leone, Andrea Matticola, Luigi Raffo, Paolo Meloni","doi":"10.1109/TBCAS.2025.3575327","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3575327","url":null,"abstract":"<p><p>The development of epilepsy monitoring solutions suitable for everyday use is a very challenging task, where different constraints should be combined, resulting from the required accuracy standards, the unobtrusiveness of the monitoring device, and the efficiency of real-time operation. Considering the time-varying nature of the electroencephalography signal (EEG), Spiking Neural Networks (SNNs) represent a promising solution to model the evolution of the brain state based on the history of the previously processed signal. This work proposes an extremely lightweight SNN-based seizure detection solution, utilizing a simple encoding scheme to ensure high levels of sparsity. Despite the reduced complexity, the model provides a detection performance comparable with the state-of-the-art SNN-based approaches on the evaluated data from the CHB-MIT dataset, reaching a 96% area under the curve (AUC) and allowing 99.3% average accuracy, with the detection of 100% of the examined seizure events and a false alarm rate of 0.3 false positives per hour. The suitability for real-time inference execution on wearable monitoring devices was assessed on SYNtzulu, demonstrating 0.5 μs inference time with 4.55 nJ energy consumption.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 96 dB Input Dynamic Range Galvanic Skin Response Readout IC with 3.5 pArms Input-Referred Noise for Mental Stress Monitoring.","authors":"Yi-Jie Lin, Lin Chou, Kun-Ju Tsai, Yu-Te Liao","doi":"10.1109/TBCAS.2025.3573614","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3573614","url":null,"abstract":"<p><p>This paper presents a low-noise, low-power galvanic skin response (GSR) sensing circuit capable of simultaneously measuring skin conductance level (SCL) and skin conductance response (SCR) for psychological stress monitoring. The circuit incorporates second-order sub-ten-hertz filters that suppresses out-of-band interference and a programmable gain amplifier (PGA) to accommodate signals of varying magnitudes. Additionally, a dynamic range adjustment mechanism optimizes the primary amplifier's operating range based on real-time SCL readings. The design achieves a 96.4 dB dynamic range with an input-referred noise of only 3.47 pArms within 0.5-5 Hz under optimal conditions. These advancements significantly enhance measurement accuracy and robustness for wearable stress monitoring and real-time biofeedback applications.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thorir Mar Ingolfsson, Victor Kartsch, Luca Benini, Andrea Cossettini
{"title":"A Wearable Ultra-Low-Power System for EEG-based Speech-Imagery Interfaces.","authors":"Thorir Mar Ingolfsson, Victor Kartsch, Luca Benini, Andrea Cossettini","doi":"10.1109/TBCAS.2025.3573027","DOIUrl":"https://doi.org/10.1109/TBCAS.2025.3573027","url":null,"abstract":"<p><p>Speech imagery-the process of mentally simulating speech without vocalization-is a promising approach for brain-computer interfaces (BCIs), enabling assistive communication for individuals with speech impairments or to enhance privacy. However, existing EEG-based speech imagery systems remain impractical for use outside specialized laboratories due to their reliance on high-channel-count and resource-intensive machine learning models running on external computing platforms. In this work, we present the first end-to-end demonstration of EEG-based speech imagery decoding on a low-channel, ultra-low-power wearable device. Building on our previous work on vowel imagery, we introduce an extended framework leveraging the BioGAP platform and VOWELNET, a lightweight neural network optimized for embedded speech imagery classification. In particular, we demonstrate state-of- the-art accuracy in the classification of an expanded vocabulary comprising vowels, commands, and rest states (13 classes) with a subject-specific training approach, achieving up to 50.0% for one subject (42.8% average) in multi-class classification. We deploy our model on an embedded biosignal acquisition and processing platform (BioGAP), based on the GAP9 processor, for real-time inference with minimal power consumption (25.93 mW). Our system achieves continuous execution for more than 21 hours on a small LiPo battery while maintaining classification latencies of 40.9 ms. Finally, we also explore the benefits of applying Continual Learning techniques to progressively improve the system's performance throughout its operational lifetime, and we demonstrate that electrodes located on the temporal area contribute the most to the overall accuracy. This work marks a significant step toward practical, real-time, and unobtrusive speech imagery BCIs, unlocking new opportunities for covert communication and assistive technologies.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}