Yining Wang, Yiyang Liu, Alistair Gorman, Robert K Henderson
{"title":"Characterization of a Pixel-level Binarized Autocorrelator for Large Array Multispeckle Diffuse Correlation Spectroscopy under Photon-starved Conditions.","authors":"Yining Wang, Yiyang Liu, Alistair Gorman, Robert K Henderson","doi":"10.1109/TBCAS.2026.3690899","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3690899","url":null,"abstract":"<p><p>Multispeckle Diffuse Correlation Spectroscopy (mDCS) is an advanced optical technology used to measure microvascular blood flow in deep tissue. It has emerged as a promising tool for continuous, real-time monitoring in clinical studies. However, its adoption in wearable applications is limited by the high resource demand for autocorrelation computation. To address this, we propose a resource-efficient 1-bit autocorrelator for in-pixel computation that exploits the inherent sparsity of photon detection events in long source-detector separation scenarios. By binarizing the detected photon counts, this architecture eliminates the need for multi-bit multipliers and reduces the bitwidth of shift registers. The proposed design is implemented on an FPGA and validated using real Single Photon Avalanche Diode (SPAD) inputs against a conventional 5-bit baseline under identical experimental conditions. It achieves 79% and 29.5% reductions in Look-Up Table and Flip-Flop usage, respectively. Systematic characterization using a rotating diffuser experimentally identifies an empirical threshold of 0.7 for the photon hit probability per lag bin, below which the 1-bit system estimates the decay time constant with tolerable error, closely matching the 5-bit baseline. The practical viability of this architecture is also demonstrated through a qualitative cuff occlusion measurement. This work presents a proof-of-concept for the 1-bit autocorrelator as a highly scalable solution toward massively parallel, large-array mDCS systems-on-chip for wearable healthcare devices.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyun-Su Lee, Kyeongho Eom, Joonghoon Kang, Hojae Chon, Taewoo Kim, Jaesoon Joo, Taekyung Kim, Young-Min Shon, Hyung-Min Lee
{"title":"A Single-Stage Single-Coil Wireless Multi-Channel Adiabatic Supply Stimulation System for Multiple Source Current Steering Deep Brain Stimulation.","authors":"Hyun-Su Lee, Kyeongho Eom, Joonghoon Kang, Hojae Chon, Taewoo Kim, Jaesoon Joo, Taekyung Kim, Young-Min Shon, Hyung-Min Lee","doi":"10.1109/TBCAS.2026.3685780","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3685780","url":null,"abstract":"<p><p>This paper presents a single-stage single-coil wireless multi-channel adiabatic supply stimulation (M-CASS) system that generates four separate adiabatic supplies to independently regulate four constant stimulus currents, without using power-hungry current sources, regardless of stimulus current and load impedance. A wireless power distributor, combined with an AC-DC quadruple-output current regulator, independently controls four stimulus channels while receiving AC power from a single wireless link. A channel-optimized size control technique and a wide adaptive offset control scheme are employed to enhance the peak AC-to-stimulation efficiency in wireless adiabatic stimulation. The 2.72 mm<sup>2</sup> 0.25-μm CMOS M-CASS demonstrates four independently controlled stimulus currents with four adiabatic supplies over a 6.78-MHz resonant link. Furthermore, M-CASS achieves a peak AC-to-stimulation efficiency of 82.2% when steering four 2-mA currents and maintains approximately 80% efficiency even when the four channels experience different impedances and currents. These features of M-CASS using a single coil provide a compact and energy-efficient solution for multiple-source current-steering (MSCS) deep brain stimulation (DBS) applications.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaeouk Cho, Daehyeok Park, Jaeseong Park, Minjae Kim, Geunchang Seong, Yujun Bae, Chul Kim
{"title":"On-Device Maternal-Fetal Heart Monitoring from Abdominal ECG Using a NEO-Based Adaptive Predictor.","authors":"Jaeouk Cho, Daehyeok Park, Jaeseong Park, Minjae Kim, Geunchang Seong, Yujun Bae, Chul Kim","doi":"10.1109/TBCAS.2026.3685945","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3685945","url":null,"abstract":"<p><p>Existing non-invasive fetal ECG (FECG) systems often rely on external computation via wireless links, limiting their feasibility for long-term, battery-powered use. To overcome this limitation, a hardware-efficient signal processing architecture that performs fetal and maternal heart rate extraction fully on the device is presented. Key signal processing steps include parallel maternal/fetal band-pass filtering and a nonlinear energy operatorbased adaptive predictor to robustly identify maternal and fetal R-peaks in real time. Evaluated on public abdominal ECG datasets, the proposed on-device system achieved high fetal R-peak detection performance with an average F1-score of greater than 96.0%. Moreover, the system outputs processed results-specifically, fetal and maternal RR intervals-thereby reducing data transmission by greater than 99.9% compared to raw signal transmission. This fully on-device approach eliminates the need for high-data-rate wireless streaming, demonstrating its practical feasibility for continuous wearable FECG monitoring.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shijia Du, Yangfan Xuan, Yili Shen, Xin Xie, Weixiao Wang, Lianyi Xie, Cheng Han, Bo Zhao
{"title":"A Wireless Battery-Free Probe-Free Disposable Electrical-Digital-PCR Chip.","authors":"Shijia Du, Yangfan Xuan, Yili Shen, Xin Xie, Weixiao Wang, Lianyi Xie, Cheng Han, Bo Zhao","doi":"10.1109/TBCAS.2026.3682919","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3682919","url":null,"abstract":"<p><p>As the most fundamental and widely-used technique in molecular diagnostics, polymerase chain reaction (PCR) plays a crucial role across various applications including epidemic surveillance and medical diagnosis. For the numerous epidemics such as COVID-19, the massive and frequent detection has challenged the PCR equipment in system miniaturization and hardware cost efficiency as well as rapid and precise detection. In conventional methods, fluorescence-PCR requires huge costly optical instruments, and the DNA-Probe-PCR can only detect a corresponding sample. In addition, both the fluorescence-PCR and DNA-Probe-PCR suffer from complex pre-label or modification procedure, further increasing the fabrication cost. In this work, we demonstrate the first probe-free electrical-digital-PCR (EdPCR) chip based on impedance detection: 1) A sensor-on-circuit structure is proposed to replace the bulky costly optical instrument with a single CMOS chip, enabling the PCR equipment to be portable and disposable. 2) A harmonic-voting method is proposed to reduce the testing pixel error rate (PER). The system is implemented in 55nm CMOS process, and in-vitro PCR experiment is conducted in various samples. The on-chip sensing array of the proposed PCR chip achieves a pixel density of 1111 pixels/mm<sup>2</sup>, which is the highest in the state of the arts. Additionally, the proposed harmonic-voting method reduces the measured PER of impedance judgment by 35%, achieving an average PER of 12.2%.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yili Shen, Yekan Chen, Changgui Yang, Tingting He, Chaonan Yu, Jun Zhou, Yuxuan Luo, Kedi Xu, Gang Pan, Yunshan Zhang, Bo Zhao
{"title":"A 32-Channel Neural-Recording Chip Achieving 117dB Intrinsic-CMRR and 100dB PSRR by CM-Tracking-Dynamic-Power-Rail and CM-Canceling-in-Idle-Phase Techniques.","authors":"Yili Shen, Yekan Chen, Changgui Yang, Tingting He, Chaonan Yu, Jun Zhou, Yuxuan Luo, Kedi Xu, Gang Pan, Yunshan Zhang, Bo Zhao","doi":"10.1109/TBCAS.2026.3683086","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3683086","url":null,"abstract":"<p><p>Multi-channel neural recording enables simultaneous monitoring of neuronal activities across multiple brain regions, while the in-vivo common-mode interference (CMI) significantly degrades the signal quality of implantable neural-recording chips. For a multi-channel neural-recording chip, the total common-mode rejection ratio (T-CMRR) of the analog front-end (AFE) is limited by the input imbalance between the signal electrode and the shared reference electrode, as well as the intrinsic CMRR (I-CMRR) of its circuits. The traditional common-mode replication (CM-REP) technique is only applicable to single-channel systems such as ECG monitoring devices. In addition, conventional pre-amplifier and frequency-controlled differential regulator (FCDR) techniques suffer from gain mismatch and high power consumption, respectively. To address these issues, this work presents a 32-channel neural-recording chip fabricated in a 65 nm CMOS process, which effectively suppresses the CMI in two operational modes: 1) In high-gain mode, the proposed CM-tracking-dynamic-power-rail (CM-TDPR) instrumentation amplifier (IA) achieves 50 GΩ CM input impedance, 117 dB I-CMRR, and 100 dB power supply rejection ratio (PSRR), resulting in a T-CMRR of 87 dB; 2) In low-gain mode, a CM-canceling-in-idle-phase (CM-CIP) technique is proposed to increase the I-CMRR to 102 dB and match the signal-reference input impedance, thereby achieving a 95 dB T-CMRR. In-vivo experiments were conducted on a Sprague-Dawley rat, successfully validating the CMRR performance of the proposed chip.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wearable 3D Transmitter for Omnidirectional Wireless Energy Delivery for Microrobot.","authors":"Heng Zhang, Chi-Kwan Lee","doi":"10.1109/TBCAS.2026.3680158","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3680158","url":null,"abstract":"<p><p>Capsule robot has emerged as a non-invasive and painless diagnostic tool for gastrointestinal examination. However, the growing demand for high-definition video and advanced functionalities significantly increases power consumption, while the capsule's compact size imposes stringent battery constraints. Wireless power transfer (WPT) offers a promising solution to overcome this energy bottleneck. This paper presents a wearable three-dimensional transmitting coil (3DTC) and a one dimensional receiving coil (1DRC) to enable omnidirectional and uninterrupted wireless charging for capsule robots. By acquiring attitude data from the capsule, the magnetic field of the wearable 3DTC is adaptively controlled to maximise receiving efficiency despite changes in the capsule's position and orientation. The capsule's built-in thermal and charging management circuits monitor the device's temperature, battery voltage, and stop charging when necessary to ensure safety. Beyond demonstrating a maximum received power of 1690 mW and a peak efficiency of 16.09%, this work further examines a range of practical challenges including, the effects upon the flexible coil bending in garment, charging robustness under various capsule motions, and thermal safety. These evaluations contribute to safer, more efficient, and more sustainable ingestible biomedical devices.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gourab Barik, Sukriti Shaw, Baibhab Chatterjee, Shreyas Sen
{"title":"A Fast-Charging Inductive-Capacitive Dual-Mode Orthogonal Orientation-Independent Switched-Mode Wireless Power Transfer System for Battery-Less Implantable Medical Devices in 65nm CMOS.","authors":"Gourab Barik, Sukriti Shaw, Baibhab Chatterjee, Shreyas Sen","doi":"10.1109/TBCAS.2026.3680951","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3680951","url":null,"abstract":"<p><p>Batteryless implantable medical devices (IMDs) require tens of μW to mW-level power while operating under stringent size constraints, uncertain post-implant orientation, and high body-channel attenuation that forces high-ratio voltage multiplication and slow energy accumulation. This paper presents a Inductive-Capacitive dual mode wireless power transfer (WPT) system that improves charging latency and link robustness by combining three techniques: (i) a split rectifier (REC) architecture with temporal energy combining to mitigate stage-leakage and accelerate energy accumulation, (ii) an orthogonal coil-fed cuboid receiver that provides spatially neutral (orientation-independent) operation, and (iii) dual-mode inductive-capacitive powering by reusing the same conductors as both inductive coils and capacitive electrodes. A load-isolating switch (LIS) further suppresses leakage during startup, reducing the average load-leakage. Fabricated in 65-nm CMOS, the 0.19 mm<sup>2</sup> prototype achieves ~3.4× faster charging compared to the TEG/solar based prior-art design. In addition, under identical input conditions of -12 dBm at 70 MHz, the proposed 4 × 60-stage split-rectifier architecture demonstrates approximately 4× reduction in charging time compared to a conventional 240-stage implementation. The WPT system achieves a minimum input power sensitivity of -26 dBm (2.5 μW) and operates with input amplitudes down to ~30 mV, enabling compact, faststarting, and spatially robust wireless powering for IMDs.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 23-µJ-per-frame All-on-Chip TinyML U-Net Processor for Real-Time Autonomous Image Segmentation in Miniaturized Ultrasound Devices.","authors":"Zhiye Song, Ulkuhan Guler, Anantha Chandrakasan","doi":"10.1109/TBCAS.2026.3676752","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3676752","url":null,"abstract":"<p><p>Autonomous medical image segmentation enables critical applications, including urinary retention monitoring, prenatal fetal biometry, neuromodulation, and cardiovascular monitoring. Its deployment in wearable ultrasound patches demands on-device processing to preserve patient privacy and enable operation beyond clinical facilities. U-Net achieves state-of-the-art performance for biomedical segmentation, and recent binarized U-Nets retain high clinical accuracy with dramatically reduced computational cost. However, existing binary neural network (BNN) accelerators cannot support medicalgrade segmentation due to missing accuracy-enhancing features, poor hardware utilization for compute-optimal layers, and memory bottlenecks requiring costly external DRAM. This work presents a 0.81 mm<sup>2</sup> fully-integrated U-Net processor in 28nm featuring: 1) mixed-precision datapaths combining binary convolution with 4-bit skip connections for clinical accuracy; 2) systematic design space exploration across 9,390 configurations optimizing energylatency tradeoffs; 3) interleaved memory representation and halo reuse for energy-efficient battery-powered operation; and 4) hardware-supported layer fusion and lossless compression eliminating external memory while reducing peak on-chip usage by 3.16× and 1.38×, respectively. Validated on bladder and fetal head segmentation datasets, the processor achieves 13.4 frames per second (fps) and 23 µJ per frame, enabling real-time autonomous monitoring in wearable medical devices.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Bimodal Imaging Wireless Capsule Endoscopy System with Precise Linear Magnetic Navigation and Motion-robust Power Transfer.","authors":"Jinlei Jiang, Qichao Li, Weicheng Wang, Cheng Zhou, Wei Wang, Daxiang Cui","doi":"10.1109/TBCAS.2026.3672399","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3672399","url":null,"abstract":"<p><p>Gastric cancer remains a global health challenge with high mortality rates, underscoring the urgent need for advanced diagnostic tools. While conventional gastroscopy encounters patient reluctance due to procedural discomfort, wireless capsule endoscopy (WCE) provides a non-invasive alternative but faces challenges, including intricate motion control, constrained power supply, and restricted detection capability. This study presents a bimodal imaging WCE system that integrates near-infrared fluorescence and white-light imaging, enhanced with linear magnetic navigation and motion-robust wireless power transfer. The innovative geometrically polarized permanent magnet configuration enables sensorless adaptive and precise linear navigation (position accuracy: 0.29 mm; orientation accuracy: 0.97<sup>°</sup>). The axially self-aligning coil configuration achieves motion-robust power transfer, with capacity further enhanced by a novel internal magnet layout. Experimental validation demonstrates stable high-power reception (2 W), reduced operator dependency through the linear navigation, and improved lesion detection capability via bimodal imaging. This breakthrough addresses the fundamental limitations of current WCE systems, showcasing a mechatronic approach to advance gastric cancer diagnostics.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congyi Qian, Sai Li, Heng Liang, Hongyuan Zhang, Songping Mai
{"title":"A Dual-mode FSK Wireless Power and Data Transfer System with 1.1 Mbps Data Rate and Rectifier Output Power of 148 mW for Implantable Medical Applications.","authors":"Congyi Qian, Sai Li, Heng Liang, Hongyuan Zhang, Songping Mai","doi":"10.1109/TBCAS.2026.3670033","DOIUrl":"https://doi.org/10.1109/TBCAS.2026.3670033","url":null,"abstract":"<p><p>This paper proposes a wireless power and data transfer (WPDT) system for implantable medical applications, featuring a simple structure, high data rate (DR), and efficient power transmission. To streamline the frequency-shift keying (FSK) data transmission link, the FSK modulator integrates merely one oscillator and one frequency divider, while the FSK demodulator requires only one D flip-flop and one delay unit. This minimalist design generates two FSK carrier signals with a large frequency difference, simultaneously enhancing the data transmission rate and reducing the bit error rate (BER). To meet the WPDT system's requirements for high power transmission under transient conditions and low coupling coefficients, a coupled network capacitive compensation technique is employed. This method significantly enhances the power transmission capability of one carrier frequency, enabling greater power delivery to the load (PDL) of that carrier frequency during non-data transmission periods. Relevant circuits were fabricated using the 180 nm BCD process, and a prototype WPDT system based on these circuits has been successfully developed. Test results show that under a low coupling scenario (17.5 mm coil spacing), the system achieves a PDL of 148 mW while maintaining a DR of 1.1 Mbps with a BER below 10<sup>-8</sup>. This work fully verifies the system's feasibility and provides an efficient, reliable technical solution for wireless power supply and data transmission in implantable medical devices.</p>","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":"PP ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}