Experimental gerontology最新文献

{"title":"SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging","authors":"Xi Chen ,&nbsp;Yingxiao Zhang ,&nbsp;Yuxing Zhao ,&nbsp;Min Zhou ,&nbsp;Pan Cheng ,&nbsp;Hong Yang ,&nbsp;Yue Shu ,&nbsp;Liang Duan ,&nbsp;Yongxin Wu ,&nbsp;Yue Sun ,&nbsp;Yuan Gao ,&nbsp;Kexiang Zhao ,&nbsp;Qian Xiao ,&nbsp;Jing Yu","doi":"10.1016/j.exger.2025.112880","DOIUrl":"10.1016/j.exger.2025.112880","url":null,"abstract":"<div><div>Ferroptosis has been implicated in skeletal muscle aging. Nevertheless, specific ferroptosis-related genes (FRGs) governing skeletal muscle aging remain unclear. The aim of this study was to identify ferroptosis-related marker genes associated with skeletal muscle aging, uncovering potential therapeutic targets for skeletal muscle aging. Data from GSE38718 was utilized to identify differentially expressed FRGs (DE-FRGs) in aging versus normal human skeletal muscle by the least absolute shrinkage and selection operator (LASSO) and the support vector machine recursive feature elimination (SVM-RFE) algorithms. Validation was conducted using RT-qPCR and Western blot in aging mouse muscle and D-galactose (D-gal)-treated C2C12 cells. SLC38A1 was identified as a significantly downregulated marker for aging skeletal muscle. Overexpression of SLC38A1 mitigated cellular aging in D-gal treated C2C12 cells. In both D-gal treated and sh-SLC38A1 C2C12 cells, increased ROS levels, elevated mtROS, higher intracellular iron concentrations, and intensified lipid peroxidation were observed. In contrast, SLC38A1 overexpression markedly reduced the accumulation of ROS, mtROS, iron concentration, and lipid peroxidation associated with D-gal treatment in these cells. In conclusion, through screening analyses and validation experiments, we identified SLC38A1 as a ferroptosis-related regulator for skeletal muscle aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112880"},"PeriodicalIF":4.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of walking training with and without a robot and standard care on clinical and mobility outcomes: A randomized clinical trial in acute ischemic stroke patients","authors":"József Tollár ,&nbsp;Szilvia Kóra ,&nbsp;Klaudia Széphelyi ,&nbsp;István Drotár ,&nbsp;Péter Prukner ,&nbsp;Blanka Törő ,&nbsp;Nándor Prontvai ,&nbsp;Bence Csutorás ,&nbsp;Tamás Haidegger ,&nbsp;Tibor Hortobágyi","doi":"10.1016/j.exger.2025.112882","DOIUrl":"10.1016/j.exger.2025.112882","url":null,"abstract":"<div><h3>Background</h3><div>Stroke incidence rises with age. A stroke can severely affect walking ability, requiring therapy. Robot-assisted walking therapy (ROB) has been advocated as one form of walking rehabilitation in stroke patients. However, its comparative efficacy remains controversial and three-group comparisons are scant. We compared the effects of ROB, walking training therapy without a robot (WTT) and standard treatment therapy (STT) on clinical and mobility outcomes in acute ischemic stroke patients.</div></div><div><h3>Methods</h3><div>Individuals (<em>n</em> = 45, 71 % males, age 64.4y ±6.34), who have recently experienced an ischemic stroke, were randomized to ROB, WTT or STT. Clinical and mobility outcomes were assessed before and after each intervention (3 weeks, 5 sessions/week) and after 5 weeks of no-intervention follow-up.</div></div><div><h3>Results</h3><div>Outcomes did not differ between groups at baseline (<em>p</em> &gt; 0.05). Modified Rankin Scale (primary outcome), improved (<em>p</em> &lt; 0.05) after ROB and WTT vs. STT. These improvements were retained relative to baseline (p &lt; 0.05) after follow-up. Barthel index, Berg Balance Scale, 10-m walking speed, the distance while walking with and without the robot for six minutes, and center pressure velocity in standing improved most after ROB (all <em>p</em> &lt; 0.001), exceeding the changes after WTT which in turn were greater than the changes after STT (<em>p</em> ≤ 0.040).</div></div><div><h3>Conclusion</h3><div>Older adults shortly after an ischemic stroke can quickly learn to walk with a soft robot and retain substantial clinical and mobility improvements at follow-up.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112882"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of sulfasalazine for sarcopenia: Insights from mouse models and clinical data","authors":"Meehee Park ,&nbsp;Seungju Cho ,&nbsp;Seonggyu Choi ,&nbsp;Hwayoung Lee ,&nbsp;Jandee Lee ,&nbsp;Youngsuk Jo ,&nbsp;Jisoo Park ,&nbsp;Jongsun Park","doi":"10.1016/j.exger.2025.112883","DOIUrl":"10.1016/j.exger.2025.112883","url":null,"abstract":"<div><div>Sarcopenia, a disease marked by a progressive loss of muscle mass, increases the risks of disability and metabolic disorders, and decreases quality of life. Current therapeutic options are limited. YY1 transcriptional activity is augmented through an interaction with PHF20 at its promoter region, suppressing muscle differentiation. This study screened sulfasalazine, a medication for managing inflammatory bowel diseases (IBD), using the PHF20-YY1 promoter assay in C₂C₁₂ myoblasts from an FDA-approved drug library. Sulfasalazine effectively inhibited PHF20-induced YY1 promoter activity (IC₅₀ = 24 μM), reducing YY1 expression and enhancing muscle-specific gene expression. In mouse models of muscle atrophy, sulfasalazine not only enhanced muscle strength and function but also mitigated muscle loss. Clinical data from patients with IBD revealed that those treated with sulfasalazine had a significantly higher TPI (total psoas index), used as a muscle mass marker, suggesting enhanced muscle preservation. In conclusion, this study suggests the potential for repurposing sulfasalazine to manage sarcopenia, especially associated with IBD.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112883"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement","authors":"Hafiza Khushbakht Hussain ,&nbsp;Nida Rasheed ,&nbsp;Zohabia Rehman ,&nbsp;Sehrish Hanif ,&nbsp;Waseem Ashraf ,&nbsp;Syed Muhammad Muneeb Anjum ,&nbsp;Rana Muhammad Zahid Mushtaq ,&nbsp;Naeem Akhtar ,&nbsp;Faleh Alqahtani ,&nbsp;Imran Imran","doi":"10.1016/j.exger.2025.112881","DOIUrl":"10.1016/j.exger.2025.112881","url":null,"abstract":"<div><div>Late-life depression (LLD) arises from the confluence of neurochemical dysfunction, oxidative stress, and neural network disintegration, presenting a formidable therapeutic challenge. Here, we demonstrated that combined vitamin D (Vit D) and L-theanine (L-thea) administration exerts multimodal neurorestorative effects in an aged murine model of unpredictable chronic mild stress (UCMS), addressing the core triad of LLD pathology: dopaminergic decline, redox imbalance, and thalamocortical dyssynchrony. Using a comprehensive battery of behavioral assays (Open Field Test, Elevated Plus Maze, Hole Board Test, Tail Suspension Test, Forced Swim Test, Sucrose Preference Test), we observed profound anxiogenic and anhedonic phenotypes in the UCMS-exposed mice, accompanied by elevated immobility and suppressed exploratory drive. Co-treatment with L-theanine (2 mg/kg) and vitamin D (500 IU/kg) robustly reversed these deficits, surpassing the efficacy of monotherapy (<em>P</em> &lt; 0.05). Electrophysiologically, Vit D + L-thea restored alpha oscillations (8–13 Hz power: 2.33-fold increase vs. UCMS, <em>P</em> &lt; 0.0001), indicating recovered thalamocortical coherence, which is a biomarker of cognitive-emotional integration. Amperometric brain homogenate analysis revealed dopaminergic recovery (Δcurrent = 1.99 μA vs. UCMS 0.66 μA), paralleled by supra-normalized antioxidant defenses as evidenced by significant reductions in MDA and enhancements in endogenous antioxidant enzymes (SOD, catalase, <em>P</em> &lt; 0.0001). These convergent outcomes underscore multimodal therapeutic action of combination, targeting the GABA-glutamate balance, dopaminergic tone, oxidative stress, and cortical oscillatory stability. This combination presents a transformative approach for LLD, particularly in frail, treatment-resistant populations, where polypharmacy risks prevail. Our study bridges nutritional neuroscience and geriatric psychiatry, offering a path to resilience against the converging tides of stress and aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112881"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined aerobic and resistance exercise on arterial stiffness in middle-aged and older men with dysglycemia and dyslipidemia: A 12-week intervention study","authors":"Yifan Feng ,&nbsp;Boming Li ,&nbsp;Peng Lu ,&nbsp;Boli Cheng ,&nbsp;Zhengxuan Bao ,&nbsp;Liqiang Su ,&nbsp;Dayong Qiu ,&nbsp;Yunqing Liu ,&nbsp;Fanghui Li","doi":"10.1016/j.exger.2025.112879","DOIUrl":"10.1016/j.exger.2025.112879","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to evaluate the effects of 12-week combined aerobic and resistance exercise program on vascular function in individuals with dysglycemia and dyslipidemia.</div></div><div><h3>Methods</h3><div>Participants aged 45–69 years with a Body Mass Index (BMI) &lt; 35 kg/m² and abnormal blood glucose or lipid levels were included. All participants performed two aerobic training sessions and one resistance training session per week for 12 weeks.</div></div><div><h3>Results</h3><div>After a 12-week intervention of aerobic exercise combined with resistance training, significant reductions in weight, BMI, blood glucose, Glycosylated Hemoglobin, Type A1C (HbA1c), low-density lipoprotein (LDL), and diastolic blood pressure in individuals with dysglycemia and dyslipidemia. The right cardio-ankle vascular index (CAVI) and the bilateral ankle-brachial index (ABI) showed highly significant enhancement (p &lt; 0.001). When grouping based on pre-exercise blood glucose levels, only the impaired fasting glucose group exhibited significant improvement in right CAVI (p = 0.045) and left ABI (p = 0.039). Comparison between the groups revealed that the ABI after exercise was significantly higher in the normoglycaemic individuals than in the other two groups (p = 0.029). Both blood glucose levels and exercise significantly affected left ABI changes (p = 0.017), but no interaction was found (p = 0.081). When grouping was based on pre-exercise lipid levels, analysis showed no significant CAVI changes, but bilateral ABIs improved significantly. Furthermore, a notable association between HbA1c changes and right ABI (p = 0.049).</div></div><div><h3>Conclusions</h3><div>The exercise regimen significantly improved arterial stiffness, while reducing obstruction in those with abnormal glucose and lipid metabolism. The extent of ABI improvement correlated with reductions in HbA1c (p = 0.049), suggesting that exercise positively influences vascular function, potentially modulated by glucose levels.</div></div><div><h3>Clinical relevance</h3><div>Supplementing measures to lower blood glucose during exercise may benefit vascular function. Trial registration: IRB number is NNU202310007.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112879"},"PeriodicalIF":4.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis of inhibition of advanced glycation end-products accumulation and prevention of aging muscle deterioration in animals and human models","authors":"Moon Jin Lee ,&nbsp;Jin-Ho Park ,&nbsp;Seong-Min Hong ,&nbsp;Sun Yeou Kim ,&nbsp;Jiyoun Kim","doi":"10.1016/j.exger.2025.112866","DOIUrl":"10.1016/j.exger.2025.112866","url":null,"abstract":"<div><h3>Background</h3><div>Advanced glycation end-products (AGEs) contribute to metabolic dysfunction and sarcopenia by promoting oxidative stress and inflammation. The therapeutic impact of exercise on AGEs-induced muscle deterioration and clinical relevance of skin autofluorescence (SAF) as a biomarker remain unclear. Therefore, we aimed to comprehensively investigate the physiological effects of AGEs using two complementary approaches.</div></div><div><h3>Methods</h3><div>This study comprised an animal experiment and a human observational study. In Experiment 1, male mice were administered methylglyoxal (MGO) to induce muscle atrophy and treated with or without treadmill exercise for 12 weeks. Muscle morphology, function, and atrophy-related markers were evaluated. In Experiment 2, 37 older adults (≥65 years) were stratified into low-SAF (&lt;2.3 arbitrary units [AU]) and high-SAF (&gt;2.7 AU) groups. Nε-(carboxymethyl)lysine (CML) and secreted protein acidic and rich in cysteine (SPARC) levels were compared.</div></div><div><h3>Results</h3><div>In mice, muscle atrophy induced by MGO was associated with upregulation of MuRF1 and Atrogin-1, increased fibrosis, and suppression of MyoD and myogenin proteins. Aerobic exercise prevented these effects, restoring muscle mass, enhancing glucose transporter type 4 and myosin heavy chain expression, and reducing SMAD2/3 signaling. In humans, the high-SAF group showed elevated insulin resistance, higher CML, reduced SPARC, and poor performance in grip strength, five times sit-to-stand (STS), 2-min walk test, and STS power. SAF positively correlated with CML and negatively with muscle function.</div></div><div><h3>Conclusions</h3><div>Aerobic exercise mitigates AGEs-induced muscle deterioration through molecular and structural improvements. SAF and CML may serve as noninvasive biomarkers of functional decline in older adults. These findings highlight the potential of exercise to counteract sarcopenia associated with AGEs accumulation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112866"},"PeriodicalIF":4.3,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social determinants of health on mortality risk in older adults with osteopenia or osteoporosis","authors":"Mingzhen Yang ,&nbsp;Ping Wang ,&nbsp;Guanghua Liu ,&nbsp;Mingfang Shi ,&nbsp;Ruijun Xue ,&nbsp;Yuanyuan Liu ,&nbsp;Bangzhong Liu","doi":"10.1016/j.exger.2025.112871","DOIUrl":"10.1016/j.exger.2025.112871","url":null,"abstract":"<div><h3>Background</h3><div>Osteopenia and osteoporosis are prevalent bone disorders among older adults that impose substantial health and economic burdens. This study aimed to explore the associations between social determinants of health (SDOH) and mortality risk in this vulnerable population.</div></div><div><h3>Methods</h3><div>We analyzed data of 3087 older adults (mean age 70.62 years, 66.95 % women) from the 2005–2010, 2013–2014, and 2017–2018 cycles of National Health and Nutrition Examination Survey. SDOH were quantified using an 8-item composite score and categorized into four groups: 7–8 (reference) group, 5–6 group, 3–4 group, and 0–2 group. The primary and secondary outcomes were all-cause and cardiovascular disease (CVD) mortality, respectively. Mortality risks were assessed using Cox proportional hazards models, restricted cubic splines, and stratified analyses.</div></div><div><h3>Results</h3><div>During a median follow-up period of 79 months, 913 (25.11 %) death occurred, including 302 CVD mortality. Compared to the reference group, multivariable-adjusted hazard ratios (95 % confidence intervals) for the SDOH 5–6 group, 3–4 group, and 0–2 group were 1.38 (1.18–1.61, <em>P</em> &lt; 0.001), 1.92 (1.48–2.50, P &lt; 0.001), and 2.11 (1.41–3.14, <em>P</em> &lt; 0.001), respectively, for all-cause mortality, and 1.58 (1.14–2.20, <em>P</em> = 0.006), 2.29 (1.54–3.39, P &lt; 0.001), and 2.57 (1.45–4.55, <em>P</em> = 0.001), respectively, for CVD mortality. Restricted cubic spline curves demonstrated a significant inverse linear relationship between SDOH score and mortality risk. Results remained consistent across sex, race/ethnicity, physical activity, and body mass index subgroups.</div></div><div><h3>Conclusion</h3><div>Adverse SDOH demonstrates a strong, graded association with elevated mortality risk in older adults with osteopenia or osteoporosis. Systematic SDOH screening and targeted interventions may reduce mortality disparities in this population.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112871"},"PeriodicalIF":4.3,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic inflammation and cognitive frailty in older adults: A narrative review","authors":"Qiqi Jiang ,&nbsp;Jinyang Li ,&nbsp;Shijie Zhao ,&nbsp;Yanxia Lin ,&nbsp;Nannan Li ,&nbsp;Chunwei Wu ,&nbsp;Wen Tian ,&nbsp;Guoxian Qi ,&nbsp;Liye Shi ,&nbsp;Ling Chen","doi":"10.1016/j.exger.2025.112875","DOIUrl":"10.1016/j.exger.2025.112875","url":null,"abstract":"<div><div>Cognitive Frailty (CF) is a clinical syndrome characterized by the co-occurrence of physical frailty and cognitive impairment in the absence of dementia. This geriatric condition has emerged as a significant contributor to compromised health status and diminished quality of life among aging populations, yet its underlying pathological mechanisms remain incompletely elucidated. Chronic low-grade inflammation, recognized as a hallmark of biological aging, has been implicated in the pathogenesis of multiple age-related diseases, including hypertension, diabetes, panvascular diseases, and cerebrovascular disorders. Given the established associations between these inflammatory-related diseases and CF progression, systemic inflammation is hypothesized to constitute a pivotal pathophysiological mediator in CF development. We systematically searched PubMed and Web of Science databases (from inception to July 2025) using MeSH terms (e.g., Inflammation, Frailty, Cognitive decline, Cognitive Frailty, Microcirculation) and related keywords. This comprehensive review synthesizes current evidence regarding the inflammation-CF nexus, particularly emphasizing the potential role of microcirculation dysfunction as a mechanistic link. This review aims to advance our pathophysiological understanding and identify potential intervention targets, thereby facilitating the development of predictive models for CF risk stratification in older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112875"},"PeriodicalIF":4.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes and sarcopenia: A bibliometric exploration of mechanisms, comorbidities, and therapeutic frontiers—an evidence mapping study","authors":"Lili Chen ,&nbsp;Jinghan Zheng ,&nbsp;Bo Ye ,&nbsp;Yuxin Huang ,&nbsp;Zhenrong Wang","doi":"10.1016/j.exger.2025.112874","DOIUrl":"10.1016/j.exger.2025.112874","url":null,"abstract":"<div><h3>Background</h3><div>The increasing global prevalence of diabetes has highlighted sarcopenia as a significant emerging complication. While numerous studies have explored the association between diabetes and sarcopenia, a comprehensive synthesis of the research landscape and its evolving trends remains limited. This study employs bibliometric analysis to provide an objective overview, identify key contributors, and uncover emerging research frontiers.</div></div><div><h3>Methods</h3><div>We systematically retrieved articles on diabetes and sarcopenia published over the past two decades from the Web of Science Core Collection. Using advanced bibliometric tools (VOSviewer, CiteSpace, and R software), we analyzed publication trends, collaboration networks, and thematic clusters. Visualization techniques were applied to map the distribution of research outputs by country, institution, journal, and author, as well as to identify high-impact keywords and references.</div></div><div><h3>Results</h3><div>A total of 1608 articles were sourced from 75 countries and 561 institutions. China had the highest publication output, while the most productive institution was from Yonsei University in South Korea. The most prolific author was Fukui M from Japan. Among high-yield journals, the <em>Journal of Cachexia, Sarcopenia and Muscle</em> from Germany had the highest Impact Factor (IF). The hot keywords of strong citation burst strength were “sarcopenia”, “insulin resistance”, “skeletal muscle”, “older adults” and “metabolic syndrome”. Furthermore, frontier topics in recent years included “hepatocellular carcinoma” and “non-alcoholic fatty liver disease”.</div></div><div><h3>Conclusion</h3><div>This study provides a comprehensive bibliometric analysis of the relationship between diabetes and sarcopenia, offering insights into the evolution of research themes and identifying potential areas for future investigation. The findings underscore the importance of early intervention and multidisciplinary approaches to improve diagnosis, treatment, and patient outcomes. By mapping the current landscape, this work aims to guide future studies and address critical knowledge gaps.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112874"},"PeriodicalIF":4.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From strength to strain: How sarcopenia contributes to chronic low back pain","authors":"Zening Zhang ,&nbsp;Yaxing Guan ,&nbsp;Shu Xie","doi":"10.1016/j.exger.2025.112872","DOIUrl":"10.1016/j.exger.2025.112872","url":null,"abstract":"<div><h3>Social media abstract</h3><div>Sarcopenia, the age-related loss of muscle mass and function, may be a hidden driver of chronic low back pain (CLBP). This study explores the link between declining muscle quality and persistent back pain, highlighting the importance of early detection, exercise, and nutrition in prevention and treatment. A stronger back starts with stronger muscles.</div><div>#Sarcopenia #LowBackPain #ChronicPain #MuscleHealth #HealthyAging</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112872"},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}