Experimental gerontology最新文献

{"title":"Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort","authors":"Ruitong Liao ,&nbsp;Jinzhao Yang ,&nbsp;Xiaoping Huang ,&nbsp;Yue Xu ,&nbsp;Qianqian Ji ,&nbsp;Qi Liu ,&nbsp;Shan Xu ,&nbsp;Peiyi Liu ,&nbsp;Yiqiang Zhan","doi":"10.1016/j.exger.2025.112770","DOIUrl":"10.1016/j.exger.2025.112770","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults.</div></div><div><h3>Methods</h3><div>Data from 45,093 participants in the 1988–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follow-up through December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AD mortality. Restricted cubic spline analysis explored the non-linear association of DII with AD mortality, and stratified analyses identified higher-risk subgroups.</div></div><div><h3>Results</h3><div>Over a median follow-up of 14.3 years, 455 AD-related deaths occurred. Participants in the highest DII quartile (&gt;2.41) had a 1.50-fold increased risk of AD mortality (95 % CI: 1.12–2.01) compared to the lowest quartile (≤−0.44). Pro-inflammatory diets (DII &gt; 0) were associated with a 44 % higher risk of AD mortality (HR: 1.44, 95 % CI: 1.14–1.81). A dose-response relationship was observed, with increased risks across quartiles, and findings were consistent across demographic and clinical subgroups.</div></div><div><h3>Conclusions</h3><div>Higher DII levels were significantly associated with elevated AD mortality risk, highlighting the potential role of pro-inflammatory diets in AD-related outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112770"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis","authors":"Jinhao Zhang ,&nbsp;Wei Ye ,&nbsp;Wang Li ,&nbsp;Fan Zhang ,&nbsp;Zhijian Wu","doi":"10.1016/j.exger.2025.112768","DOIUrl":"10.1016/j.exger.2025.112768","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequately defined. To address these gaps, we conducted a network meta-analysis synthesizing direct and indirect evidence from existing literature to identify the most effective exercise interventions for enhancing cognitive function in older adults.</div></div><div><h3>Methods</h3><div>We conducted a systematic search across databases including PubMed and Web of Science to identify randomized controlled trials (RCTs) evaluating the impact of various exercise interventions on cognitive function in older adults. We assessed the quality of included studies and performed a traditional meta-analysis with Review Manager 5.3. Subsequently, a network meta-analysis was conducted using Stata 17.0 to evaluate the effects of different exercise modalities on cognitive outcomes, specifically memory, inhibitory control, and task-switching abilities.</div></div><div><h3>Results</h3><div>A total of 37 studies encompassing 2585 older adults met the inclusion criteria. The network meta-analysis revealed that resistance training exerted the strongest effect on overall cognitive improvement. Aerobic exercise, multimodal exercise, and physical-mental training followed in effectiveness. Specifically, resistance training significantly enhanced inhibitory control compared to high-intensity interval training (HIIT), aerobic exercise, and other modalities. Physical-mental training emerged as the most effective intervention for improving task-switching ability and demonstrated superior efficacy in enhancing working memory compared to aerobic exercise. Conversely, aerobic exercise showed the strongest effect on memory function, outperforming resistance training, multimodal exercise, and physical-mental training.</div></div><div><h3>Conclusion</h3><div>Resistance training is the most effective exercise modality for enhancing overall cognitive function and inhibitory control in older adults. Physical-mental training offers the greatest benefits for improving working memory and task-switching ability, while aerobic exercise is most beneficial for enhancing memory function. Based on these findings, the recommended exercise protocols are: Resistance Training: 12 weeks, 2–3 times per week, 45 min per session. Aerobic Exercise: 21 weeks, twice per week, 60 min per session. These tailored exercise interventions can inform public health strategies and clinical practices aimed at optimizing cognitive health in the aging population.</div></div><div><h3>Registration</h3><div>The protocol for this review was registered in PROSPERO (CRD42024597545).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112768"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of functional disability with cardiometabolic disease status in a national cohort study","authors":"Ping Ni ,&nbsp;Fang Wang ,&nbsp;Li Liu ,&nbsp;Meiling Ge ,&nbsp;Xiuying Hu","doi":"10.1016/j.exger.2025.112771","DOIUrl":"10.1016/j.exger.2025.112771","url":null,"abstract":"<div><h3>Background</h3><div>Cardiometabolic disease (CMD) status increases the risk of functional disability; however, the reverse relationship remains unclear. This study aimed to examine the impact of different patterns of functional disability on CMD status among Chinese middle-aged and older adults.</div></div><div><h3>Methods</h3><div>We used data from two waves of the China Health and Retirement Longitudinal Study. Functional disability was assessed based on activities of daily living (ADL) and instrumental activities of daily living (IADL), while CMD status was evaluated based on the incidence of diabetes, heart disease, and stroke. Generalized ordinal logistic regression analysis was employed to investigate the impact of functional disability on CMD status.</div></div><div><h3>Results</h3><div>In the longitudinal study, 509 individuals (20.0 %) developed CMD, and 102 individuals (4.0 %) developed cardiometabolic multimorbidity. After adjusting for confounders, Model 1 showed an odds ratio of 1.64 (95 % CI: 1.17, 2.29) for increased CMD status in individuals with ADL and IADL disability compared to those without functional disability. Model 2 and Model 3 produced similar results.</div></div><div><h3>Conclusions</h3><div>Functional disability, particularly ADL and IADL disability, increases the risk of CMD status in Chinese middle-aged and older adults. Measures should be implemented to maintain functional status in middle-aged and older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112771"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigation of learning and memory impairment caused by acute total sleep deprivation through OX1R/OX2R-mediated hippocampal neurogenesis in rats","authors":"Yixin Yu ,&nbsp;Na Shao ,&nbsp;Xiao Zhang ,&nbsp;Wanyu Zhao ,&nbsp;Baokun Zhang ,&nbsp;Jiyou Tang ,&nbsp;Shi Tang","doi":"10.1016/j.exger.2025.112769","DOIUrl":"10.1016/j.exger.2025.112769","url":null,"abstract":"<div><div>Sleep deprivation (SD) impairs learning and memory, which may be correlated with hippocampal neurogenesis. To observe the effects on learning and memory and hippocampal neurogenesis in the hippocampal CA1 area, we first transfected lentivirus to downregulate orexin receptor function in rats. Then, we established a rat model of 72 hourh SD. The Y-maze and Morris water maze tests were deployed to evaluate learning and memory of the rats after SD, 14 days sleep recovery and 28 days sleep recovery. Hippocampal neurogenesis was quantified using BrdU-NeuN immunofluorescence in the dentate gyrus (DG). The results showed that SD impaired learning and memory and reduced the generation of new neurons in DG. The cognition impairments were improved at 14 and 28 days after sleep recovery, but the differentiation and maturation of DG neurons were inhibited during 28 days of sleep recovery. Following the downregulated orexin receptor function after SD, the impairments of learning and memory were alleviated and DG neurogenesis were protected. We hypothesized that the downregulation in orexin receptor function could attenuate the cognition impairment by SD and exert a neuroprotective effect in hippocampus, and this process could be related to the OX1R/OX2R mediated hippocampal neurogenesis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112769"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test","authors":"Daniel Jiménez-Lupión ,&nbsp;Ignacio Chirosa-Ríos ,&nbsp;Rodrigo Lizama-Pérez ,&nbsp;Luis Chirosa-Ríos ,&nbsp;Daniel Jerez-Mayorga","doi":"10.1016/j.exger.2025.112767","DOIUrl":"10.1016/j.exger.2025.112767","url":null,"abstract":"<div><div>Muscle power is a better indicator of musculoskeletal health and functional capacity than muscle strength. The Load-Velocity (L-V) relationship provides a method for assessing muscle function during dynamic multi-joint movements, making it valuable for identifying age-related neuromuscular decline. This study aimed to examine the relationship between variables derived from the L-V relationship (L₀, V₀, and A_line) obtained during the loaded sit-to-stand test and various muscle performance indices, including knee extension peak force (KEPF) and various muscle quality indices (MQI).</div><div>A total of 113 participants (49 middle-aged adults and 64 older adults; age = 61 ± 9.92 years) performed the loaded 5-Sit-To-Stand using Functional Electromechanical Dynamometry. L-V variables were calculated, and their relationships with indicators of muscle performance and quality were analyzed. The impact of age on these variables was also evaluated. The results showed a high positive correlation between A_line and KEPF, MQI_Equation1, MQI_Equation2 and MQI_Equation3 (rs = 0.56–0.59, <em>p</em> ≤0.001–0.01), and between V₀ and KEFP (rs = 0.51, <em>p</em> &lt; 0.001). Older adults exhibited significantly lower L₀ compared to middle-aged adults (76.86 ± 29.74 kg vs. 94.62 ± 35.69 kg, <em>p</em> = 0.007), as well as lower V₀ (0.92 ± 0.28 m·s⁻¹ vs. 1.22 ± 0.19 m·s⁻¹, <em>p</em> &lt; 0.001) and A_line values (35.39 ± 18.95 kg·m·s⁻¹ vs. 57.75 ± 23.84 kg·m·s⁻¹, p &lt; 0.001). These findings suggest that L-V variables are valuable indicators for assessing muscle function deterioration and guiding training interventions, providing a more comprehensive and sensitive assessment of muscle quality and functional status in aging populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112767"},"PeriodicalIF":3.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial investigating the effect of a Baduanjin exercise plus nutrition programme on cancer-related fatigue in elderly lung cancer patients receiving chemotherapy","authors":"Jing Wu ,&nbsp;Chuanfeng Zhang ,&nbsp;Zhao Jing ,&nbsp;Xiushao Wu","doi":"10.1016/j.exger.2025.112763","DOIUrl":"10.1016/j.exger.2025.112763","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to evaluate the benefits of the Baduanjin exercise and nutrition intervention on Cancer-related fatigue (CRF) in elderly lung cancer patients undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>96 elderly patients suffering from lung cancer and undergoing chemotherapy were enlisted and randomly assigned to the control group, the exercise group, and the exercise plus nutrition group. Primary and secondary endpoints were assessed at baseline, week 6, and week 12, including Brief Fatigue Inventory (BFI) scores, Pittsburgh Sleep Quality Index (PSQI) scores, grip strength, and gait speed.</div></div><div><h3>Results</h3><div>Significant beneficial intervention effects were found for CRF, sleep quality, grip strength, and gait speed in the exercise plus nutrition group at 6 and 12 weeks after the treatment. The exercise group improved CRF, grip strength, and gait speed at 12 weeks. No beneficial effects on the outcomes were noticed in the control group.</div></div><div><h3>Conclusions</h3><div>Baduanjin exercise may help alleviate CRF in elderly lung cancer patients undergoing chemotherapy. Moreover, when combined with nutrition intervention, it appears to enhance their sleep quality and physical function more substantially than Baduanjin alone.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112763"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wrist rotation metrics as digital biomarkers for detecting physio-cognitive decline syndrome in older adults","authors":"Wei-Ju Lee ,&nbsp;Po-Yan Lin ,&nbsp;Min-Hsuan Chin ,&nbsp;Chih-Chieh Chang ,&nbsp;Chen-Wei Chang ,&nbsp;Hsiao-Wen Zan ,&nbsp;Chia-Huei Tseng ,&nbsp;Liang-Kung Chen","doi":"10.1016/j.exger.2025.112766","DOIUrl":"10.1016/j.exger.2025.112766","url":null,"abstract":"<div><h3>Introduction</h3><div>Physio-cognitive decline syndrome (PCDS) is a reversible condition affecting physical and cognitive health in older adults. Early detection is essential to facilitate timely interventions. This study aimed to evaluate wrist rotation metrics as potential biomarkers for PCDS and explore their applicability in digital health tools.</div></div><div><h3>Methods</h3><div>This pilot study recruited 50 community-dwelling individuals aged 50 years or older from Yi-Lan County, Taiwan, including 19 with PCDS and 31 robust participants. Wrist rotation movements were assessed using a custom device, and statistical analyses, including logistic regression and receiver operating characteristic (ROC) curve analysis, were performed to evaluate the diagnostic accuracy of the metrics.</div></div><div><h3>Results</h3><div>Two rotation metrics, Rotate (60°–30°) and the ratio Rotate (30°–90°)/Rotate (60°–90°), were significantly associated with PCDS. The ratio metric demonstrated high sensitivity, making it suitable for initial screening, while Rotate (60°–30°) exhibited high specificity, supporting its use as a confirmatory test. These complementary roles highlight the potential of these metrics in tiered diagnostic frameworks.</div></div><div><h3>Conclusions</h3><div>Wrist rotation metrics show promise as scalable and non-invasive tools for detecting PCDS. These findings support their integration into digital platforms, such as smartphone applications, for early screening and intervention. Further studies are needed to validate these findings in larger, diverse populations and to assess their utility in monitoring disease progression and guiding interventions to improve physical and cognitive health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112766"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty index and epigenetic aging acceleration in older adults: Evidence from the health and retirement study","authors":"Xuhui Lin ,&nbsp;Zhao Hu ,&nbsp;Lu Tang ,&nbsp;Yiqiang Zhan","doi":"10.1016/j.exger.2025.112765","DOIUrl":"10.1016/j.exger.2025.112765","url":null,"abstract":"<div><h3>Backgound</h3><div>This study aimed to examine the associations between the frailty index and four epigenetic aging acceleration (EAA) estimators in cross-sectional and longitudinal settings.</div></div><div><h3>Methods</h3><div>The frailty index in the older adults was measured according to a cumulative health-deficit model. Four different epigenetic age measures (Hannum, PhenoAge, GrimAge, and DunedinPoAm38) were regressed against chronological age, and the resulting standardized residuals were indicative of EAA. The longitudinal relationship between EAA at baseline and changes in the frailty index during the 4-year follow-up were examined using a mixed linear model.</div></div><div><h3>Results</h3><div>A single standard deviation (SD) increment in the frailty index was associated with a faster EAA, as indicated by the four clocks in Hannum (b = 0.057; <em>P</em> = 0.015), PhenoAge (b = 0.096; <em>P</em> &lt; 0.001), GrimAge (b = 0.120; P &lt; 0.001), and DunedinPoAm38 (b = 0.062; <em>P</em> = 0.002) in the fully adjusted model. A 1-SD increment in the GrimAge EAA was associated with a 0.003 frailty index increase (b = 0.003; P = 0.002). A 1-SD increment in DunedinPoAm38 EAA was associated with a 0.002 frailty index increase (b = 0.002; <em>P</em> = 0.009).</div></div><div><h3>Conclusions</h3><div>The frailty index was cross-sectionally associated with EAA, while only GrimAge and DunedinPoAm38 EAA predicted changes in the frailty index. More research is needed to understand the interplay between pathways.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112765"},"PeriodicalIF":3.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women","authors":"Stephen J. Carter ,&nbsp;Tyler H. Blechschmid ,&nbsp;Emily B. Long ,&nbsp;Tenzin Yangchen ,&nbsp;Marissa N. Baranauskas ,&nbsp;Chad C. Wiggins ,&nbsp;John S. Raglin ,&nbsp;Andrew R. Coggan","doi":"10.1016/j.exger.2025.112764","DOIUrl":"10.1016/j.exger.2025.112764","url":null,"abstract":"<div><div>Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m²; <em>n</em> = 14) or older (≥65 y; 81.8 ± 10.4 kg/m²; <em>n</em> = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O_2peak). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O₂). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O₂. However, older women had lower aerobic capacity (<em>p</em> = 0.002, <em>ES</em> = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (<em>p</em> = 0.042, <em>ES</em> = 0.41). Among all participants, and independent of V̇O_2peak, MRT correlated with average daily fatigue (<em>r</em> = 0.500, <em>p</em> = 0.015), fatigue interference (<em>r</em> = 0.421, <em>p</em> = 0.046), and POMS total mood disturbance (<em>r</em>_<em>s</em> = 0.437, <em>p</em> = 0.037). Regression modeling revealed MRT and walking net V̇O₂ jointly explained 55 % (<em>R</em> = 0.744, <em>p</em> &lt; 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O₂ may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112764"},"PeriodicalIF":3.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxidative stress in the association between metabolic score for insulin resistance and stroke: evidence from two large population-based studies","authors":"Yi Tan ,&nbsp;Xing Lin ,&nbsp;Liquan Xie","doi":"10.1016/j.exger.2025.112761","DOIUrl":"10.1016/j.exger.2025.112761","url":null,"abstract":"<div><h3>Objective</h3><div>This study endeavors to unveil the association between the Metabolic Score for Insulin Resistance (METS-IR) and stroke among adults utilizing data of the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS), and whether oxidative stress (OS) mediates their association.</div></div><div><h3>Methods</h3><div>Our study cohort comprised 101,316 individuals from NHANES and 17,708 individuals from CHARLS. The intricate relationships among the METS-IR, stroke, and OS biomarkers were evaluated via logistic regression, restricted cubic splines (RCS), as well as mediation analysis.</div></div><div><h3>Results</h3><div>The final analysis included 22,542 American and 9521 Chinese participants, among whom 844 and 887 were diagnosed with stroke, respectively. Regression analysis indicated a positive association of METS-IR with stroke [NHANES: <em>OR</em> = 1.01, <em>95 % CI</em> (1.01, 1.02), <em>p</em> &lt; 0.001; CHARLS: <em>OR</em> = 1.02, <em>95 % CI</em> (1.02, 1.03), <em>p</em> &lt; 0.001], with higher METS-IR quartiles being associated with elevated stroke incidence [NHANES: <em>OR</em> = 1.39, <em>95 % CI</em> (1.11, 1.73), <em>p</em> = 0.004; CHARLS: <em>OR</em> = 1.74, <em>95 % CI</em> (1.39, 2.17), <em>p</em> &lt; 0.001]. Participants with elevated METS-IR and serum uric acid (SUA) exhibited the greatest probability of stroke. Mediation analysis proved that OS partially mediated this association [Mediation effect: NHANES <em>β</em> = −8.45e−5, <em>95 % CI</em> (−1.41e−4, −4.01e−5), <em>p</em> &lt; 0.001; CHARLS <em>β</em> = −4.02e−5, <em>95 % CI</em> (−8.14e−5, −7.76e−6), <em>p</em> = 0.012].</div></div><div><h3>Conclusion</h3><div>The METS-IR was positively associated with stroke in NHANES and CHARLS cohorts, and OS partially mediated this association.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112761"},"PeriodicalIF":3.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}