Experimental gerontology最新文献

{"title":"Irisin and the muscle–brain axis: Mechanisms and translational potential","authors":"Beatrice Arosio ,&nbsp;Anna Picca","doi":"10.1016/j.exger.2026.113028","DOIUrl":"10.1016/j.exger.2026.113028","url":null,"abstract":"<div><div>The muscle–brain axis integrates peripheral metabolic activity with central nervous system function. Among the endocrine signaling molecules regulating such crosstalk, the peptide hormone irisin released during muscle contraction seems to play relevant roles. Irisin is generated by the proteolytic cleavage of the fibronectin type III domain-containing protein 5 and has emerged as a key regulator of neurotrophic and metabolic adaptation. Although initially described as a myokine, irisin is also expressed in adipose and neural tissues, acting through autocrine, paracrine, and endocrine mechanisms. Irisin binds to the αV/β5 integrin receptor complex and activates a network of signaling pathways which promote mitochondrial biogenesis, autophagy, oxidative stress resistance, and modulation of inflammatory responses. Within the central nervous system, irisin induces brain-derived neurotrophic factor expression and contributes to synaptic plasticity, neurogenesis, and cognitive preservation. Experimental models show that irisin reduces amyloid burden, limits α-synuclein pathology, suppresses neuroinflammation, and stabilizes blood–brain barrier integrity, supporting a disease-modifying role in neurodegenerative conditions. In skeletal muscle, irisin stimulates myogenesis, enhances anabolic signaling, and improves metabolic efficiency, suggesting broader relevance for sarcopenia and age-related metabolic decline. Herein, we discuss irisin as a promising biomarker and a candidate therapeutic target for disorders characterized by concurrent muscle deterioration and cognitive impairment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113028"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of grip indicators with post-discharge recovery in geriatric and hip fracture inpatients","authors":"Myrthe Swart ,&nbsp;Merle Geerds ,&nbsp;Ivan Bautmans ,&nbsp;Liza De Dobbeleer ,&nbsp;Siddharta Lieten ,&nbsp;Hugo Plácido da Silva ,&nbsp;Rudi Tielemans ,&nbsp;Cindel Bonneux ,&nbsp;Yvonne Schoon ,&nbsp;Geeske Peeters ,&nbsp;Marcel Olde Rikkert ,&nbsp;Dieuwke van Dartel ,&nbsp;René Melis","doi":"10.1016/j.exger.2025.113014","DOIUrl":"10.1016/j.exger.2025.113014","url":null,"abstract":"<div><h3>Objectives</h3><div>Hand grip measures offer potential indicators for recovery after hospitalization in older adults. We investigated prospective associations of the grip indicators maximal grip strength (GSmax), fatigue resistance (FR) and grip work (GW) with post-discharge functional limitations, health-related quality of life (HRQOL) and survival in older inpatients.</div></div><div><h3>Methods</h3><div>Grip indicators were evaluated at admission in general geriatric inpatients (GGI, <em>n</em> = 149) and geriatric hip fracture inpatients (HIP, <em>n</em> = 109). Questionnaires on functional limitations (10–40, lower is better) were collected for two weeks pre-admission, admission, three months follow-up, and six months follow-up. HRQOL (−4–10, higher is better) was assessed at admission, three months follow-up and six months follow-up. With individual growth modeling, we established the associations between grip indicators and the outcome trajectories. Three-month survival was analyzed using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>In GGI, higher FR and GW were associated with better functional recovery from admission to three months follow-up (FR: B = −1.0 points per 10s increase, 95 %CI −1.9, −0.14; GW: B = −0.33 points per 100 kPa × s increase, 95 %CI −0.59, −0.07). HIP with higher grip indicators showed a better functional recovery towards three months follow-up (GSmax: B = −2.4 per 10 kPa increase, 95 %CI −3.9, −0.89; FR: B = −1.1, 95 %CI −2.4, 0.20; GW: B = −0.31, 95 %CI −0.61, −0.02). No or weak associations were found between grip indicators and HRQOL recovery. Hazard ratios pointed towards a better survival for better scores on grip indicators, but associations were not statistically significant.</div></div><div><h3>Conclusion</h3><div>Higher FR and GW at admission were associated with better recovery post-discharge in geriatric inpatients. Future research should examine the added clinical value of grip indicators in addition to known patient characteristics.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113014"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity–frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study","authors":"Stefano Cacciatore ,&nbsp;Riccardo Calvani ,&nbsp;Konstantinos Prokopidis ,&nbsp;Mathias Schlögl ,&nbsp;Andrea Russo ,&nbsp;Matteo Tosato ,&nbsp;Stephen D. Anton ,&nbsp;Christiaan Leeuwenburgh ,&nbsp;John A. Batsis ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi","doi":"10.1016/j.exger.2026.113026","DOIUrl":"10.1016/j.exger.2026.113026","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC–frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains (locomotion, cognition, vitality, psychological well-being, and sensory function), rescaled to a 0–100 range, and combined with frailty status to define four IC–frailty phenotypes (concordant frail, discordant low IC, discordant high IC, concordant robust). Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured, and a composite inflammatory burden score (0–3) was derived.</div></div><div><h3>Results</h3><div>The analysis included 311 participants (mean age 85.4 ± 4.7 years, 66.6 % women). Median CRP, IL-6, and TNF-α levels increased progressively from concordant robust to concordant frail groups (<em>p</em> &lt; 0.01). In the fully adjusted model, concordant frail participants had higher inflammation compared with concordant robust (β = 0.71; 95 % CI 0.04–1.37; <em>p</em> = 0.03), while discordant high IC and discordant low IC showed intermediate values without statistical significance. A significant linear trend was observed across ordered phenotypes (β per category increment = 0.21, 95 % CI 0.06 to 0.37). Locomotion and vitality emerged as the domains most strongly linked to inflammation.</div></div><div><h3>Conclusions</h3><div>IC–frailty phenotypes show a biological gradient of subclinical inflammation, with higher IC having lower inflammation levels. Preserved locomotion reflects key functional correlates of resilience and vitality in advanced age.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113026"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary inflammation index and peripheral neuropathy: Insights into the role of biological aging from a cross-sectional NHANES study","authors":"Shishuang zhang ,&nbsp;Han Gao ,&nbsp;Yaru Liu ,&nbsp;Yongle Zhi ,&nbsp;Yu Du","doi":"10.1016/j.exger.2026.113031","DOIUrl":"10.1016/j.exger.2026.113031","url":null,"abstract":"<div><h3>Objectives</h3><div>Peripheral neuropathy (PN) is a prevalent neurological disorder with significant health and socio-economic burdens. The Dietary Inflammatory Index (DII) systematically assesses the proinflammatory characteristics of dietary patterns. This study aimed to elucidate the complex relationships among DII, biological aging, and PN, and to deepen the understanding of the potential factors driving these associations, thereby providing novel insights for prevention and clinical intervention.</div></div><div><h3>Methods</h3><div>This study investigated the National Health and Nutrition Examination Survey 1999–2004 data. The linear association between DII and PN was assessed using binary logistic regression, while restricted cubic splines were employed to evaluate potential nonlinear relationships. Furthermore, mediation analysis was conducted to quantify the contribution of biological age in this association.</div></div><div><h3>Results</h3><div>This study enrolled and analyzed 7860 participants. DII revealed a significant correlation with the prevalence of PN (the odds ratio [OR] = 1.07, 95% confidence interval [CI]: 1.03–1.30, <em>p</em> &lt; 0.001). A J-shaped nonlinear association was identified between DII and the PN (<em>p</em> = 0.0079), with an inflection point at 1.295. Beyond this threshold, OR significantly increased to 1.16 (95% CI: 1.03–1.30). Biological age contributed to 19.95% of the total association between DII and PN.</div></div><div><h3>Conclusions</h3><div>This study demonstrates a J-shaped association between DII and PN, which is partially accounted for by biological aging. These findings provide a new perspective for preventing PN through a low-inflammation diet.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113031"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional immunology in lifespan","authors":"Maryam Fallah ,&nbsp;Fatemeh Naeini ,&nbsp;Fatemeh Sadat Fahimzad ,&nbsp;Ali Nouri ,&nbsp;Sayyed Mehdi Rasooli Manesh ,&nbsp;Alireza Haghighi ,&nbsp;Soraiya Ebrahimpour-Koujan","doi":"10.1016/j.exger.2025.113015","DOIUrl":"10.1016/j.exger.2025.113015","url":null,"abstract":"<div><div>Immunonutrition refers to nutritional interventions that can improve immune function. The nutritional contents used in immunocytes include amino acids, vitamins, minerals, and flavonoids.</div><div>In this study, we examine the oxi-inflamm-aging theory, which illustrates the antioxidant effects of diet, immune system performance, and life span. According to this theory, if vitamin C is consumed in the early stages of life, it can increase life span. The main objective of this study was to investigate the potential role of key immunonutrients in modulating immune system activity and lifespan through antioxidant and anti-inflammatory mechanisms. Vitamin E can reduce the mortality caused by the disease by inhibiting the oxidative damage associated with aging and inducing the P21 signaling pathway as an anti-cancer pathway. Also, vitamin D can reduce aging by increasing the expression of skinhead-1 (SKN-1), a gene of stress response pathways, inhibition of toxicity caused by human β-amyloid, and insolubility of proteins as a molecular pathology of aging. Zinc can adjust the activity of thymus and its hormones, regulating natural killer cells/Natural killer cells (NK/NKT), causing the inherent immune system responses. Moreover, Selenium can reduce the disorders induced by oxidative damage via improving the function of thyroid and immune cells, as well as metabolic and cellular redox homeostasis. Flavonoids also protect against the use of old cells and aging-related phenotypes by protecting nerve cells and metabolic homeostasis, as well as inhibiting old cells and aging phenotypes. However, the findings are still incomplete, and more studies are needed to prove this claim. Therefore, we made this study with careful attention to future issues.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113015"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145852011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol associated with all-cause mortality in oldest-old acute coronary syndrome patients: A cohort study","authors":"Zijie Dang ,&nbsp;Boning Zhou ,&nbsp;Yongkang Su ,&nbsp;Haocheng Huang ,&nbsp;Xin Zhang ,&nbsp;Yang Jiao ,&nbsp;Jian Wang ,&nbsp;Xiaoling Hou ,&nbsp;Yanru Yang ,&nbsp;Zhenhong Fu","doi":"10.1016/j.exger.2026.113047","DOIUrl":"10.1016/j.exger.2026.113047","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies showed that remnant cholesterol(RC) partially explained the residual risk of cardiovascular disease. We tried to test the hypothesis that remnant cholesterol is a risk factor for all-cause mortality and cardiovascular(CV) mortality in oldest-old(&gt;80 years old) patients with acute coronary syndrome(ACS).</div></div><div><h3>Methods</h3><div>699 oldest-old patients with ACS and undergoing coronary angiography(CAG) were included in our study. RC was calculated by fasting total cholesterol(TC) minus low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL<img>C). With a maximum follow-up period of 10 years, 37 patients were lost to follow-up, and 662 were finally available for statistical analysis. Pearson's correlation test was used to assess the associations between RC and clinical parameter. Multivariable Cox regression analysis was used to identify the association between RC and all-cause mortality. Nelson-Aalen cumulative hazard curves and Fine-Gray plots were used to assess the association between RC and clinical outcomes, including all-cause mortality, major adverse cardiovascular events (MACEs), cardiovascular (CV) mortality, and non-CV mortality. Receiver operating characteristic(ROC) curve was used to compare the discrimination capacity of RC, TC, HDL-C and LDL-C to predict all-cause mortality.</div></div><div><h3>Results</h3><div>Among the 662 oldest-old patients enrolled, 92.90% accepted statin therapy. The average age was 81.87 ± 2.14 years old. Nelson-Aalen cumulative hazard curves showed that the cumulative hazard of all-cause mortality and MACEs in the high RC tertile was higher than that in the middle or low RC tertiles. In the fully-adjusted Cox regression model, the Hazard ratio(HR) [95% confidence interval (CI)] of all-cause mortality was 1.17 (1.01, 1.44) for each standard deviation(SD) increase in RC. Compared to RC tertile 1, RC tertile 3 was associated with a 94% increased risk of all-cause mortality (HR:1.94; 95%CI: 1.22–3.10). The increased risk of all-cause death from tertile 1 to tertile 3 was statistically significant. Fine-Gray test showed that regarding CV mortality, marginally statistically significant differences in cumulative incidence were observed among the three RC tertile groups (<em>P</em> = 0.054). For non-CV mortality, statistically significant differences were detected across three groups (<em>P</em> = 0.026). The subgroup analysis confirmed the significant association between RC and all-cause mortality. ROC curve showed that RC had a better discrimination capacity at predicting all-cause mortality (AUC (95% CI): 0.621(0.575–0.666)), and improved the prognostic value of the Gensini score combined with left ventricular ejection fraction(LVEF).</div></div><div><h3>Conclusion</h3><div>Remnant cholesterol was associated with all-cause mortality in oldest-old patients with ACS in a long-term follow-up.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113047"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cognitive and motor dual-task on stability and variability of walking in younger and older adults","authors":"Jay Barolo ,&nbsp;Douglas Mitchell ,&nbsp;Francesca E. Wade","doi":"10.1016/j.exger.2026.113035","DOIUrl":"10.1016/j.exger.2026.113035","url":null,"abstract":"<div><div>Dual-task walking, performing a secondary task while walking, challenges attentional and motor resources and has been linked to increased fall risk. While cognitive dual tasks are most often studied, physical (e.g., load carriage) and “combination” tasks such as obstacle crossing may also impact gait. Whole-body angular momentum and its variability provide sensitive markers of locomotor stability. We investigated how dual-task type influences gait mechanics and stability in younger and older adults.</div><div>Sixteen adults (18–80 years) completed four treadmill conditions at preferred walking speed: baseline walking (PWS), walking while talking (WWT), box carriage (BOX, 15 lb), and obstacle crossing (OBS). Spatiotemporal measures, trailing limb angle (TLA), and whole-body angular momentum in frontal and sagittal planes were computed. Mixed-model ANOVAs and statistical parametric mapping assessed trial and age effects.</div><div>Dual tasks altered spatiotemporal gait. BOX and OBS reduced step length, and OBS also shortened step time and reduced late-stance TLA. OBS elicited consistently greater variability in step length, width, time, double-support, and whole body angular momentum in both planes (all <em>p</em> &lt; .01). Older adults took shorter steps and longer double support, with age × task interactions observed in these metrics.</div><div>Obstacle crossing imposed the greatest locomotor challenge, producing significant changes in TLA, whole body angular momentum, and variability, whereas cognitive and load carriage tasks induced smaller deviations. Findings highlight the importance of incorporating ecologically relevant “combination” tasks into gait assessment and demonstrate the utility of time-series analyses for detecting phase-specific disruptions to locomotor stability.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113035"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for 90-day readmission after single-level lumbar fusion for degenerative spondylolisthesis in older adults: A National Readmission Database Analysis, 2016–2020","authors":"Yu-Chiang Yeh","doi":"10.1016/j.exger.2026.113038","DOIUrl":"10.1016/j.exger.2026.113038","url":null,"abstract":"<div><h3>Background/aim</h3><div>Degenerative spondylolisthesis (DS) is a spinal disorder prevalent in older adults, often requiring lumbar fusion surgery. Despite the benefits of surgery, older adult patients face an increased risk of complications and readmission. This study aimed to identify risk factors for 90-day readmission following single-level lumbar fusion for DS in older adult patients.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included the data of patients aged ≥60 years who had undergone single-level lumbar fusion for DS extracted from the National Readmission Database (NRD) from 2016 to 2020. Multivariable logistic regression with backward selection was used to identify factors associated with 90-day readmission.</div></div><div><h3>Results</h3><div>Data of 32,894 older adult patients were analyzed (mean age 70 years, 65% female.) Significant predictors of readmission were age (adjusted odds ratio [aOR] = 1.02, 95% confidence interval [CI]: 1.01–1.03), having Medicare/Medicaid insurance (aOR = 1.35, 95% CI: 1.19–1.54), myocardial infarction (aOR = 1.41, 95% CI: 1.16–1.72), venous thromboembolism (aOR = 2.39, 95% CI: 1.44–3.98), bleeding (aOR = 2.63, 95% CI: 1.08–6.40), and longer hospital stay (aOR = 1.04, 95% CI: 1.03–1.06). Stratified by age ≥70 years, several different risk factors were identified between the age groups.</div></div><div><h3>Conclusion</h3><div>Risk factors influencing 90-day readmission following single-level lumbar fusion in older adults with DS include age, comorbidities, perioperative complications, insurance type, and hospital length of stay (LOS). Patient-centered (or customized) perioperative strategies and postoperative care may ultimately help to reduce readmission rates in this population.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113038"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking malnutrition through soluble RAGE: A biomarker-guided insight from FRASNET","authors":"Sarah Damanti ,&nbsp;Clara Sciorati ,&nbsp;Amanda Avola ,&nbsp;Rebecca De Lorenzo ,&nbsp;Maria Pia Ruggiero ,&nbsp;Simona Santoro ,&nbsp;Eleonora Senini ,&nbsp;Marco Messina ,&nbsp;Francesca Farina ,&nbsp;Costanza Festorazzi ,&nbsp;Giulia Pata ,&nbsp;Martina Laffranchi ,&nbsp;Martina Mallus ,&nbsp;Elena Brioni ,&nbsp;Lorena Citterio ,&nbsp;Laura Zagato ,&nbsp;Marco Simonini ,&nbsp;Chiara Lanzani ,&nbsp;Paolo Manunta ,&nbsp;Angelo Manfredi ,&nbsp;Patrizia Rovere-Querini","doi":"10.1016/j.exger.2026.113032","DOIUrl":"10.1016/j.exger.2026.113032","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is a prevalent geriatric syndrome, with multifactorial etiology and consequences for health and independence. Inflammation contributes to nutritional decline, yet conventional inflammatory markers often lack sensitivity for identifying malnutrition risk. The soluble receptor for advanced glycation end-products (sRAGE), a modulator of inflammatory responses, has emerged as a biomarker of disease risk and adverse outcomes in various conditions.</div></div><div><h3>Objectives</h3><div>to evaluate the association between circulating sRAGE levels and nutritional status in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>This prospective observational study was conducted within the FRASNET cohort. Fifty-two community-dwelling older adults underwent multidimensional geriatric assessments during two time periods: 2017–2020 and 2023–2024. Serum sRAGE levels were measured at both timepoints. Nutritional status was assessed using the Mini Nutritional Assessment Short Form (MNA-SF). Associations between sRAGE and clinical parameters were evaluated through linear regression models adjusted for age and sex. The diagnostic performance of sRAGE in identifying malnutrition was assessed using ROC curve analysis.</div></div><div><h3>Results</h3><div>Higher baseline sRAGE levels were significantly associated with lower BMI (β = −0.003, <em>p</em> = 0.036), reduced calf circumference (β = −0.002, <em>p</em> = 0.04), and poorer nutritional status as revealed by MNA-SF scores (β = −0.001, p = 0.03) at follow-up. Associations were more pronounced in women. ROC analysis indicated good diagnostic accuracy for identifying malnutrition risk, with an AUC of 0.85. The optimal sRAGE cut-off value for malnutrition risk was 1362.5 pg/ml.</div></div><div><h3>Conclusions</h3><div>Higher sRAGE levels were prospectively associated with poorer nutritional outcomes in older adults, particularly in women. sRAGE may aid early identification of inflammation-related malnutrition risk.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113032"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of paroxetine on lifespan, feeding behavior, and other physiological parameters in the nematode C. elegans under a modified bacterial diet","authors":"Abdullah M. Almotayri ,&nbsp;Ali H. Alghamdi ,&nbsp;K. ELSHERBINY ,&nbsp;Ali A. Hroobi ,&nbsp;Nourah M. Almimoni ,&nbsp;Hussam A. Althagafi ,&nbsp;Tariq Saeed Alghamdi ,&nbsp;Fatehia N. Gharsan ,&nbsp;Mariam S. Alghamdi ,&nbsp;Abdullah A.A. Alghamdi","doi":"10.1016/j.exger.2025.113022","DOIUrl":"10.1016/j.exger.2025.113022","url":null,"abstract":"<div><div>Paroxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known for its metabolic side effects, yet its long-term physiological impacts remain incompletely understood. This study investigated the effects of paroxetine on lifespan, feeding behavior, and fat accumulation in <em>Caenorhabditis elegans</em> across different developmental stages and dietary conditions. We found that low-dose paroxetine extended lifespan when exposure began early, while high doses consistently reduced lifespan. Notably, the lifespan-extending effects appeared to be diminished when worms were fed a high-glucose diet, suggesting that dietary context may influence the physiological outcomes of paroxetine. Paroxetine also increased food intake without causing fat accumulation, indicating a possible metabolic uncoupling. These effects were independent of major serotonergic, dopaminergic, and insulin-like signaling pathways, pointing to alternative mechanisms. Overall, our findings highlight the potential roles of dose, timing of exposure, and diet in shaping the physiological impacts of SSRIs.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113022"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}