Experimental gerontology最新文献

{"title":"Investigation of commonly used assessment methods for predicting fall risk in the elderly","authors":"Aziz DENGİZ ,&nbsp;Ahmet AYTEPE ,&nbsp;Bayram SIRRI ,&nbsp;Mehmet EFE","doi":"10.1016/j.exger.2025.112784","DOIUrl":"10.1016/j.exger.2025.112784","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the effectiveness of four different commonly used assessment methods Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Modified Falls Efficacy Scale (MFES), and Morse Fall Scale (MFS) in predicting fall risk in elderly.</div></div><div><h3>Method</h3><div>The study included 195 participants (97 female, mean age: 69.82 ± 7.45 years) aged 60 and above. The BBS, TUG, MFES, and MFS were used to asses fall risk. Logistic regression analysis was conduct.</div></div><div><h3>Results</h3><div>The addition of independent variables significantly reduced the −2 Log Likelihood value (from 222.015 to 49.196), and the Nagelkerke R² value was 0.865. The Hosmer-Lemeshow goodness-of-fit test (<em>p</em> = .738) and ROC analysis (AUC 0.958–0.972) confirmed the model's strong fit and high discriminative power. The MFS (B = 0.120, <em>p</em> = .001, Exp(B) = 1.128) and the TUG(B = 0.542, <em>p</em> = .004, Exp(B) = 1.720) were significantly associated with fall risk. In contrast, the MFES and BBS did not show statistically significant effects.</div></div><div><h3>Conclusions</h3><div>The MFS and TUG are particularly effective in identifying fall risk in elderly individuals. However, using these tests alone may have limited predictive power, highlighting the importance of a multidisciplinary approach for fall risk assessment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112784"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between molecular markers of biological aging and orthopedic diseases: A two-sample bidirectional Mendelian randomization study","authors":"Wei Yan ,&nbsp;Yichen Zhao ,&nbsp;Jiahui Zhang ,&nbsp;Ping Jiang ,&nbsp;Honghong Ma ,&nbsp;Min Fang ,&nbsp;Xiaobing Xi","doi":"10.1016/j.exger.2025.112785","DOIUrl":"10.1016/j.exger.2025.112785","url":null,"abstract":"<div><h3>Background</h3><div>Studies indicate an association between biological aging and orthopedic diseases, but the causality remains unclear.</div></div><div><h3>Aims</h3><div>This study aims to investigate the bidirectional causal relationship between molecular markers of biological aging age and orthopedic conditions.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian randomization (MR) analysis based on a genome-wide association study (GWAS) was conducted to explore these causal relationships. Analysis methods included inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode. Sensitivity analyses involved Cochran's Q, MR-Egger, leave-one-out, and MR pleiotropy residual sum and outlier (MR-PRESSO) tests.</div></div><div><h3>Results</h3><div>The forward MR analysis identified several causal relationships: granulocyte proportions influenced intervertebral disc degeneration (IVDD) (OR 0.2316, <em>P</em> = 0.0101) and low back pain (LBP) (OR 0.2624, <em>P</em> = 0.007); telomere length (TL) affected cervical spondylosis (C/S) (OR 0.8759, <em>P</em> = 0.0167) and IVDD (OR 0.9184, <em>P</em> = 0.023); fibroblast growth factor-23 (FGF-23) impacted frozen shoulder (FS) (OR 1.2424, <em>P</em> = 0.0316); and HannumAge influenced C/S (OR 0.9518, <em>P</em> = 0.0233). The reverse MR analysis found that FS influenced TL (OR 0.9582, <em>P</em> = 0.0002) and α-Klotho (OR 0.7592, <em>P</em> = 0.0256), while sciatica affected TL (OR 0.9344, <em>P</em> = 0.0055) and C/S impacted PhenoAge (OR 1.6583, <em>P</em> = 0.0131) after outlier exclusion. Cochran's Q indicated heterogeneity in certain analyses, and MR-Egger showed no horizontal pleiotropy in significant causal associations.</div></div><div><h3>Conclusions</h3><div>This study suggests a potential causal associations between molecular markers of biological aging and orthopedic diseases, suggesting avenues for future research into the underlying mechanisms.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112785"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between METS-VF and sarcopenia among middle-aged and older adults in China: The first longitudinal evidence from CHARLS","authors":"Tong Li ,&nbsp;Yi Ren ,&nbsp;Meilan Liu ,&nbsp;Qing Wang ,&nbsp;Tianhan Sun ,&nbsp;Jianfu Cao ,&nbsp;Hongyuan Cui","doi":"10.1016/j.exger.2025.112778","DOIUrl":"10.1016/j.exger.2025.112778","url":null,"abstract":"<div><h3>Background</h3><div>The association between the Metabolic Score for Visceral Fat (METS-VF) and sarcopenia remains unclear. This study aims to explore the relationship between METS-VF and sarcopenia in the middle-aged and older adults in China.</div></div><div><h3>Methods</h3><div>Data were collected from 2011 and 2015 of the China Health and Retirement Longitudinal Survey (CHARLS) and 2948 participants were enrolled in this study. METS-VF was calculated using data from CHARLS. Sarcopenia was defined according to the criteria set by the Asian Working Group for Sarcopenia (AWGS) 2019. Potential confounders were identified through the Directed Acyclic Graph (DAG). The association between METS-VF and sarcopenia was then analyzed using multivariate logistic regression and restricted cubic spline (RCS) analysis.</div></div><div><h3>Results</h3><div>Compared with low METS-VF, high METS-VF (OR = 1.65, 95 % CI = 1.08–2.52) showed a significant association with the occurrence of sarcopenia. Subgroup and interaction analyses revealed that residence (<em>P</em> for interaction = 0.012) influenced the relationship between METS-VF and sarcopenia. Additionally, RCS analysis demonstrated a non-linear relationship between METS-VF and sarcopenia.</div></div><div><h3>Conclusions</h3><div>There is a positive non-linear correlation between METS-VF and sarcopenia with residence showing an impact on this association. Early identification of patients with possible sarcopenia by METS-VF is of great value for disease prediction, prevention, early diagnosis and timely treatment to reduce the potential disease burden.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112778"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging","authors":"Dongfeng Lan ,&nbsp;Dan Zhang ,&nbsp;Xiaofang Dai ,&nbsp;Ji Cai ,&nbsp;He Zhou ,&nbsp;Tao Song ,&nbsp;Xianyao Wang ,&nbsp;Qinghong Kong ,&nbsp;Zhengzhen Tang ,&nbsp;Jun Tan ,&nbsp;Jidong Zhang","doi":"10.1016/j.exger.2025.112781","DOIUrl":"10.1016/j.exger.2025.112781","url":null,"abstract":"<div><div>Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating evidence from extensive research underscores the remarkable anti-aging potential of both MSCs and their Exos. This review comprehensively explores the impact of MSCs and their Exos on key hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Furthermore, this paper highlights emerging strategies and novel approaches for modulating the aging process, offering insights into potential therapeutic interventions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112781"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triglyceride-glucose index mediates associations between dietary inflammation index/Composite Dietary Antioxidant Index and cardiovascular disease incidence: insights from NHANES study","authors":"Han Gao ,&nbsp;Bo Yan ,&nbsp;Fangyuan Cheng ,&nbsp;Shishuang Zhang ,&nbsp;Pan Liao ,&nbsp;Dai Li ,&nbsp;Lin Zhang ,&nbsp;Fanglian Chen ,&nbsp;Ping Lei","doi":"10.1016/j.exger.2025.112779","DOIUrl":"10.1016/j.exger.2025.112779","url":null,"abstract":"<div><h3>Aims</h3><div>This study investigates how Dietary Inflammatory Index (DII) and Composite Dietary Antioxidant Index (CDAI) patterns relate to cardiovascular disease, with particular focus on their metabolic connections, providing novel insights for prophylaxis and remedy.</div></div><div><h3>Methods</h3><div>Data from NHANES (2009–2014) were utilized in this retrospective cross-sectional research. Binary logistic regression and the generalized linear model (GLM) were applied to assess the correlations among DII, CDAI, metabolic factors, and CVD. Moreover, causal mediation analysis was carried out to further probe into the mediating role of the TyG-index.</div></div><div><h3>Results</h3><div>Significant positive correlations between DII (odds ratio [OR] 1.08, 95 % confidence interval [CI] 1.01–1.16, <em>p</em> = 0.036) and CVD were observed, while CDAI exhibits a nonlinear association with the risk of CVD. The combined effect analysis indicated that the group with a low DII and high CDAI combination had the least risk (OR 0.52, 95 % CI 0.35–0.78, <em>p</em> = 0.002). TyG-index was found to mediate 4.95 % of the connection between DII and CVD and 8.02 % of the linkage between CDAI and CVD, respectively.</div></div><div><h3>Conclusions</h3><div>This study manifests that DII and CDAI are respectively correlated with the risk of CVD incidence. The diet low in inflammation and rich in antioxidants can safeguard against disease occurrence. Serving as a metabolic marker, the TyG-index serves to establish the connection among DII, CDAI, and the progression of CVD.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112779"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific association of oxidative balance score with sarcopenia in American adults: NHANES 2011–2018","authors":"Xinyi Pei ,&nbsp;Di Jin ,&nbsp;Lin Liu ,&nbsp;Qingrao Song ,&nbsp;Da Pan ,&nbsp;Baofu Guo ,&nbsp;Wei Xie","doi":"10.1016/j.exger.2025.112775","DOIUrl":"10.1016/j.exger.2025.112775","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Nutritional status and levels of oxidative stress may be modifiable risk factors for the development of sarcopenia. The Oxidative Balance Score (OBS) is a comprehensive measure of oxidative balance in diet and life exposures. We conducted a cross-sectional study to investigate the association between OBS and sarcopenia in US adults.</div></div><div><h3>Methods</h3><div>Based on the 2011–2018 National Health and Nutrition Examination Survey (NHANES), this study included 3084 participants. Weighted logistic regression analysis and restricted cubic spline regression (RCS) were used to assess the association between OBS and sarcopenia, as well as gender differences in this association.</div></div><div><h3>Results</h3><div>OBS and sarcopenia are negatively associated (OR = 0.951, 0.919–0.983, <em>p</em> = 0.004). Compared with the lowest quartile of OBS, the highest quartile was significantly negatively associated with sarcopenia (OR = 0.431, 0.202–0.917, <em>p</em> for trend = 0.01). Both dietary OBS and lifestyle OBS were significantly negatively associated with sarcopenia (OR = 0.963, 0.930–0.997, <em>p</em> = 0.032; OR = 0.634, 0.562–0.715, <em>p</em> &lt; 0.001). In gender subgroup analysis, a significant negative association between OBS and sarcopenia was observed in women (OR = 0.916, 0.862–0.973, <em>p</em> = 0.005), while the association was not significant in men. The RCS showed a significant linear correlation between total population OBS, female OBS and sarcopenia (<em>p</em> for nonlinear &gt;<!--> <!-->0.05, <em>p</em> for overall &lt;0.05).</div></div><div><h3>Conclusions</h3><div>Higher oxidative balance scores are associated with a lower prevalence of sarcopenia, particularly among women. These findings support the importance of antioxidant-rich diets and healthy lifestyles in mitigating sarcopenia risk, especially in aging female populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112775"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat stress effects on the immune system of older adults: A systematic literature review","authors":"Rabab Awad ,&nbsp;Assaf Suberry ,&nbsp;Ahmad Abu-Akel ,&nbsp;Liat Ayalon","doi":"10.1016/j.exger.2025.112777","DOIUrl":"10.1016/j.exger.2025.112777","url":null,"abstract":"<div><h3>Objectives</h3><div>We examined the evidence from experimental and cohort studies concerning the associations between heat stress and immune vulnerability in older adults.</div></div><div><h3>Research design and methods</h3><div>A systematic search was performed in 6 academic databases, covering all papers that were published until April 2024. We included studies that explored immune-related outcomes associated with climate change, mainly heat shock, heat exposure, extreme temperature and global warming, among older adults, aged 65 and over. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews were followed to select the studies. Records that retained the exact same search terms from databases were imported into COVIDENCE software and were screened by two independent raters. Major findings were identified and synthesised.</div></div><div><h3>Results</h3><div>Fifteen papers were considered eligible for full-text evaluation, and 4 papers met the inclusion criteria and were included in the analysis. Studies mainly point to age-related dysregulation in heat induced response of subgroups of interleukins and heat shock proteins (hsps).</div></div><div><h3>Discussion and implications</h3><div>Heat stress may directly affect the regulatory function of older adults' immune system that plays a critical rule in the course of infections and inflammatory diseases. However, this review points to a paucity of relevant studies among older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112777"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the appendicular skeletal muscle mass-to-visceral fat area ratio and bone mineral density and osteoporosis: A cross-sectional study","authors":"Jiao Liu ,&nbsp;Fujue Ji ,&nbsp;Haesung Lee ,&nbsp;Jong-Hee Kim","doi":"10.1016/j.exger.2025.112772","DOIUrl":"10.1016/j.exger.2025.112772","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study investigated the association between appendicular skeletal muscle mass-to-visceral fat area ratio (SVR), bone mineral density (BMD), and osteoporosis in U.S. adults using NHANES data.</div></div><div><h3>Methods</h3><div>Data from the 2013–2014 and 2017–2018 NHANES cycles were analyzed. Multivariable regression models assessed associations between SVR, BMD, and osteoporosis, adjusting for demographic, lifestyle, metabolic, and comorbidity variables. Generalized Additive Models with smooth curve fitting and likelihood ratio tests evaluated model fit. Subgroup analyses explored effect modifications.</div></div><div><h3>Results</h3><div>The study included 2325 individuals with a mean age of 50.66 ± 5.55 years. In fully adjusted models, the highest SVR tertile was associated with a 0.05 g/cm² higher BMD (β = 0.05, 95 % CI: 0.03–0.08, <em>P</em> = 0.002) and 57 % lower odds of osteoporosis (OR = 0.43, 95 % CI: 0.24–0.78, <em>P</em> = 0.028) than the lowest tertile. As a continuous variable, SVR remained significantly associated with BMD (β = 0.03, 95 % CI: 0.02–0.04, <em>P</em> = 0.002) and osteoporosis (OR = 0.67, 95 % CI: 0.50–0.91, <em>P</em> = 0.033). Stronger associations were found in individuals with diabetes (β = 0.09, 95 % CI: 0.06–0.12, <em>P</em> &lt; 0.01) and BMI ≥ 30 (β = 0.07, 95 % CI: 0.05–0.09, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Higher SVR was significantly associated with increased BMD and lower odds of osteoporosis, suggesting its potential as a marker for bone health assessment. However, the cross-sectional design limits causal inference. Further longitudinal and mechanistic studies are warranted to confirm these findings and explore clinical applicability.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112772"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of health literacy and self-management on quality of life among older adults with hypertension and diabetes in Northwest China","authors":"Yiliyaer Aihemaiti ,&nbsp;Zhihong Li ,&nbsp;Ying Tong ,&nbsp;Lijun Ma ,&nbsp;Fang Li","doi":"10.1016/j.exger.2025.112776","DOIUrl":"10.1016/j.exger.2025.112776","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the relationship between health literacy, self-management, and quality of life among older adults diagnosed with hypertension and diabetes. Additionally, the influence of these factors on quality of life was assessed to provide a theoretical basis for enhancing the well-being of individuals with chronic conditions.</div></div><div><h3>Methods</h3><div>A cohort of 600 older adults diagnosed with hypertension and diabetes were recruited in Xinjiang, China. Data were collected through a questionnaire survey, and the relationship between health literacy, self-management levels, and quality of life were analysed using a structural equation model (SEM).</div></div><div><h3>Results</h3><div>Of the 600 distributed questionnaires, 556 were completed. Among the older adults with hypertension and diabetes, 17 (3.0 %) demonstrated very adequate health literacy, 188 (33.8 %) had adequate health literacy, 67 (12.1 %) exhibited possible insufficient health literacy, and 284 (51.1 %) were categorized as having insufficient health literacy. The mean self-efficacy score was 6.97 ± 1.03, reflecting low levels of self-management. The average Physical Component Summary score for quality of life was 51.10 ± 12.80, while the average Mental Component Summary score was 70.89 ± 9.43. SEM analysis indicated that quality of life exerted a significant positive effect on health literacy (<em>β</em> = 0.369, <em>P</em> &lt; 0.001) and self-management (<em>β</em> = 0.133, <em>P</em> &lt; 0.01). Furthermore, health literacy was found to significantly positively influence self-management (<em>β</em> = 0.210, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Quality of life in older adults with chronic conditions is significantly influenced by their health literacy and self-management levels. Higher health literacy and improved self-management are associated with enhanced overall quality of life.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112776"},"PeriodicalIF":3.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ‘Internet + dietary diary management’ on serum TP, ALB, PA levels and nutritional risk for elderly patients with esophageal cancer","authors":"Yue Fu,&nbsp;Qingmiao Zhu,&nbsp;Chang Liu,&nbsp;Qi Li,&nbsp;Nuoxiaoxuan Wang,&nbsp;Ning Zhao","doi":"10.1016/j.exger.2025.112780","DOIUrl":"10.1016/j.exger.2025.112780","url":null,"abstract":"<div><h3>Objective</h3><div>This study examines the impact of “Internet + diet diary management” on serum total protein (TP), albumin (ALB), and prealbumin (PA) levels, as well as nutritional risk during the postoperative home care period for elderly esophageal cancer patients.</div></div><div><h3>Methods</h3><div>From May 2022 to May 2023, 74 elderly patients who underwent surgical treatment and were discharged as planned were included. Patients were assigned into a control group and a research group, with 37 in each, using a digital randomization table. Both groups received continuous nursing care, with the research group receiving additional “Internet + diet diary management” during their ongoing care. Serum levels of TP, ALB, and PA, along with other nutritional indicators and scores from the Patient-Generated Subjective Global Assessment (PG-SGA), were compared preoperatively and one month post-discharge.</div></div><div><h3>Results</h3><div>Preoperatively, there was no significant difference in serum indicators and PG-SGA scores between the two groups (<em>P</em> &gt; 0.05). One month postoperatively, the research group showed higher levels of serum ALB, TP, PA, IgA, and IgG, and lower PG-SGA scores than the control group (<em>P</em> &lt; 0.05); no significant differences were found in serum levels of IgM, CA19–9, CA72–4, cyfra21–1, NSE, SCC, and CEA between the groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The application of “Internet + diet diary management” can improve the nutritional status and reduce nutritional risk during the postoperative home care period for elderly patients with esophageal cancer.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112780"},"PeriodicalIF":3.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}