Experimental gerontology最新文献

{"title":"Foresight older adults' quality of life in the aging crisis in Iran: A systematic review and meta-analysis","authors":"Raheleh Alimoradzadeh ,&nbsp;Katayoun Jahangiri ,&nbsp;Roya Alimoradzadeh","doi":"10.1016/j.exger.2024.112671","DOIUrl":"10.1016/j.exger.2024.112671","url":null,"abstract":"<div><h3>Introduction</h3><div>To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted.</div></div><div><h3>Methods</h3><div>All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023.</div></div><div><h3>Results</h3><div>Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7.</div></div><div><h3>Conclusion</h3><div>The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112671"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents","authors":"Erivaldo Machado Araújo ,&nbsp;Hélio José Coelho-Júnior ,&nbsp;Caio Victor Sousa ,&nbsp;Thiago dos Santos Rosa ,&nbsp;Ivo Vieira Sousa Neto ,&nbsp;Emanuele Marzetti ,&nbsp;Octávio Luiz Franco ,&nbsp;Samuel da Silva Aguiar","doi":"10.1016/j.exger.2024.112662","DOIUrl":"10.1016/j.exger.2024.112662","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.</div></div><div><h3>Methods</h3><div>The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation.</div></div><div><h3>Results</h3><div>Dual-task RT significantly enhanced balance (<em>p</em> = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (<em>p</em> = 0.008) and post-detraining (<em>p</em> = 0.015) relative to baseline. Cognitive ability showed significant improvements (<em>p</em> &lt; 0.05). The CAT/TBARS ratio increased significantly post-training (<em>p</em> &lt; 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (<em>p</em> &lt; 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112662"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia: A cross-sectional study","authors":"Xiudeng Yang ,&nbsp;Zheng Zhong","doi":"10.1016/j.exger.2025.112680","DOIUrl":"10.1016/j.exger.2025.112680","url":null,"abstract":"<div><h3>Background</h3><div>The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter that's used to evaluate cardiovascular disease risk. However, its association with sarcopenia risk has not been explored before.</div></div><div><h3>Methods</h3><div>Data on NHHR and sarcopenia were based on the secondary analysis of the years 2011–2018 of National Health and Nutrition Examination Survey (NHANES) dataset. NHHR was nature log-transformed (LnNHHR) to achieve a normal distribution. A multivariate logistic regression and a restricted cubic spline (RCS) model adjusted for associated factors were utilized to evaluate the correlation between NHHR and sarcopenia. Subgroup and sensitivity analyses were conducted to verify the robustness of the findings.</div></div><div><h3>Results</h3><div>The study cohort comprised 7069 participants, of whom 6497 (91.91 %) were sarcopenia-free, and 572 (8.09 %) exhibited sarcopenia. A significant increase in NHHR was observed in the sarcopenia group compared to the non-sarcopenic group (<em>P</em> &lt; 0.001). Multivariate logistic regression analysis revealed that sarcopenia was independently linked to NHHR [odds ratio (OR): 1.394, <em>P</em> = 0.007]. A linear relationship was identified between NHHR and sarcopenia risk (<em>P</em>_non-linear = 0.108). Interaction analysis indicated that the relationship between NHHR and sarcopenia risk was not significantly modified by gender, sex, poverty income ratio, education, smoking status, or race.</div></div><div><h3>Conclusion</h3><div>NHHR was significantly associated with an elevated risk of sarcopenia among U.S. adults. Further research is warranted to elucidate the underlying physiological mechanisms through which NHHR influences sarcopenia development.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112680"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome","authors":"Valerie Lohner ,&nbsp;Laura Perna ,&nbsp;Ben Schöttker ,&nbsp;Robert Perneczky ,&nbsp;Hermann Brenner ,&nbsp;Ute Mons","doi":"10.1016/j.exger.2025.112684","DOIUrl":"10.1016/j.exger.2025.112684","url":null,"abstract":"<div><h3>Background</h3><div>In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).</div></div><div><h3>Methods</h3><div>We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (<em>n</em> = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (<em>n</em> = 377), and amyloid β (Aβ₄₀, Aβ₄₂, Aβ₄₂/Aβ₄₀) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (<em>ApoE</em>) ε4 genotype.</div></div><div><h3>Results</h3><div>Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ₄₀/Aβ₄₂-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on <em>ApoE</em> ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes.</div></div><div><h3>Conclusions</h3><div>In persons with CSS, NfL and the Aβ₄₀/Aβ₄₂-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by <em>ApoE</em> genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112684"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia","authors":"Beatrice Arosio ,&nbsp;Paolo Dionigi Rossi ,&nbsp;Evelyn Ferri ,&nbsp;Ernesto Consorti ,&nbsp;Simona Ciccone ,&nbsp;Tiziano Angelo Lucchi ,&nbsp;Nicola Montano","doi":"10.1016/j.exger.2025.112692","DOIUrl":"10.1016/j.exger.2025.112692","url":null,"abstract":"<div><h3>Background</h3><div>During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. Frailty represents a condition of increased vulnerability to stresses and reduced homeostatic reserve reflecting not only health status but also biological age. In older subjects without dementia, we showed that markers of inflammaging were differently associated with chronological age than with frailty. This study analysed the same markers in older people with cognitive decline and/or dementia.</div></div><div><h3>Methods</h3><div>The cohort consisted of 776 community-dwelling older people: 235 patients with mild cognitive impairment, 63 with Alzheimer's disease (AD), 175 with mixed dementia (MD), and 303 subjects without cognitive decline. Plasma concentrations of inflammatory cytokines and peripheral markers of neuroinflammation were analysed by next-generation ELISA.</div></div><div><h3>Results</h3><div>After adjustment for age, sex, frailty, education and Apolipoprotein E genotype, only interleukin-10, interleukin-1β, and neurofilament light chain were associated with the risk for AD and MD. Moreover, interleukin-6 showed a weak association only with AD.</div></div><div><h3>Conclusions</h3><div>Our data showed similar associations between AD and MD, supporting the concept that late-onset dementia is a complex outcome of aging, intimately linked to the individual's health status as well as frailty.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112692"},"PeriodicalIF":3.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous extract of Atractylodes macrocephala Koidz. improves dexamethasone-induced skeletal muscle atrophy in mice by enhancing mitochondrial biological function","authors":"Mingzhu Ye,&nbsp;Peng Lai,&nbsp;Yajing Fang,&nbsp;Yafeng Li,&nbsp;Fang Wang,&nbsp;Junqi Yu,&nbsp;Yuyu Zhang,&nbsp;Qiaoyi Yang,&nbsp;Jinsen Zhu,&nbsp;Xiaoqin Xie,&nbsp;Ningrong Yang,&nbsp;Tong Peng","doi":"10.1016/j.exger.2025.112693","DOIUrl":"10.1016/j.exger.2025.112693","url":null,"abstract":"<div><h3>Purpose</h3><div>The study aims to investigate the therapeutic effects of the aqueous extract of <em>Atractylodes macrocephala</em> Koidz. (AEA) on dexamethasone (Dex) -induced sarcopenia in mice and to explore its possible mechanisms of action.</div></div><div><h3>Methods</h3><div>This study utilized bioinformatics analysis to explore the primary pathogenic mechanisms of age-related sarcopenia and Dex-induced muscle atrophy. In animal experiments, a mouse model of muscle atrophy was established using Dex, and different doses of AEA were administered for treatment. The therapeutic effects of AEA were evaluated through tests of motor ability and histological analysis, and the molecular mechanisms predicted by bioinformatics were verified by measuring the expression levels of related genes.</div></div><div><h3>Results</h3><div>Bioinformatics analysis suggests that there may be shared pathogenic mechanisms related to mitochondrial function and structure between age-related sarcopenia and Dex-induced muscle atrophy. Dex significantly reduced the mass, function, and cross-sectional area of muscle fibers in mice, and also induced changes in muscle fiber types. In contrast, AEA significantly ameliorated the aforementioned atrophic effects caused by Dex. The modulation of mitochondrial biogenesis and dynamics may be a crucial mechanism by which AEA exerts its anti-sarcopenia effects.</div></div><div><h3>Conclusion</h3><div>AEA can significantly alleviate the symptoms of Dex-induced skeletal muscle atrophy in mice by improving mitochondrial function, indicating its potential for clinical application in the prevention and treatment of age-related sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112693"},"PeriodicalIF":3.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors influencing preoperative frailty in elderly patients with gynecologic oncology surgery: A cross-sectional study","authors":"Xiaofang Wu ,&nbsp;Shuo Man ,&nbsp;Haowen Huang ,&nbsp;Jinjin Yu ,&nbsp;Ling Xia","doi":"10.1016/j.exger.2025.112691","DOIUrl":"10.1016/j.exger.2025.112691","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is an important predictor of poor postoperative outcomes in elderly patients with gynaecologic cancer. However, the prevalence and risk factors for frailty in this population remain unclear.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted simultaneously in three gynecology departments of a tertiary hospital in China between January and March 2024. The study recruited 126 hospitalised patients with gynaecologic malignancies who underwent surgery. The demographic and clinical characteristics and biochemical laboratory parameters of all patients were collected. The Edmonton Frailty Scale was used to assess the patient's frailty. Multivariate logistic regression model analysis was used to identify the influencing factors of frailty.</div></div><div><h3>Results</h3><div>The prevalence of preoperative frailty was 31 %. Univariate analysis showed significant differences between frail and non-frail groups in terms of age, body mass index, menopausal status, self-management ability, nutritional risk and activities of daily living (ADL) (all <em>p</em> &lt; 0.05). Multiple logistic regression analysis identified older age (odds ratio [OR] = 1.27, 95%CI: 1.068–1.511, <em>p</em> = 0.007), ADL disability (OR = 3.184, 95%CI: 2.294–4.833, <em>p</em> = 0.010) and high nutritional risk (Nutritional Risk Screening 2002 score ≥ 3) (OR = 4.823, 95%CI: 1.422–16.816, <em>p</em> = 0.031) as risk factors for frailty. High self-management ability (OR = 0.918, 95%CI: 0.844–0.998, <em>p</em> = 0.046) was a protective factor against frailty.</div></div><div><h3>Conclusion</h3><div>Nutritional support, activity exercise and improvement of patient self-management are potential intervention goals, and nurses should develop targeted prevention strategies based on identified risk factors to protect patient health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112691"},"PeriodicalIF":3.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort","authors":"Hao Sun ,&nbsp;Dong-Wan Chen ,&nbsp;Yuan-Ye Ma ,&nbsp;Bai Liu ,&nbsp;Jun Wang ,&nbsp;Yu-Jie Lai ,&nbsp;Gui-Hua Zeng ,&nbsp;Ying-Ying Shen ,&nbsp;Cheng-Rong Tan ,&nbsp;Xian-Le Bu ,&nbsp;Fan Zeng ,&nbsp;Yan-Jiang Wang","doi":"10.1016/j.exger.2025.112689","DOIUrl":"10.1016/j.exger.2025.112689","url":null,"abstract":"<div><h3>Background</h3><div>Platelet factor 4 (PF4), a chemotactic factor secreted from the α-granules of platelets, has recently been proved to mitigate neuroinflammation and improve aging-related cognition decline, which may be involved in Alzheimer's disease (AD).</div></div><div><h3>Objective</h3><div>This study aims to investigate the alterations of serum PF4 levels in AD, the correlation between serum PF4 and β-amyloid (Aβ) and tau levels in cerebrospinal fluid (CSF), and the potential diagnostic utility of PF4 in AD.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted involving 38 amyloid-positive AD patients and 50 cognitively normal controls. The levels of serum PF4 were detected using the Human CXCL4/PF4 enzyme-linked immunosorbent assay (ELISA) Kit. The levels of CSF Aβ42, Aβ40, p-tau181, and t-tau were measured on the fully-automated Lumipulse G1200 platform via commercially available kits.</div></div><div><h3>Results</h3><div>The levels of serum PF4 were significantly decreased in AD patients (5163.51 (3198.24–6301.15) vs. 5859.29 (4126.06–8006.70), Z = −2.30, <em>P</em> = 0.021). The negative correlation between AD diagnosis (β = −1972.292, <em>P</em> = 0.009) and PF4 levels retained after the adjustments of age, sex, <em>APOE</em> ε4 status, platelet count, platelet distribution width (PDW), and comorbidity of dyslipidemia in the multiple linear regression analysis. Further analysis showed that serum PF4 levels were positively correlated with CSF Aβ42 levels and Mini-Mental State Examination (MMSE) scores, and negatively correlated with CSF t-tau levels. Besides, the area under the curve (AUC) of serum PF4 for AD (AUC = 0.6437, <em>P</em> = 0.022) was comparable to that of CSF Aβ40 (AUC = 0.6400) yet lower than those of CSF Aβ42, ptau181, and t-tau. The AUC slightly increased when combining serum PF4 with other CSF AD biomarkers separately.</div></div><div><h3>Conclusions</h3><div>The serum levels of PF4 were decreased in AD patients and were significantly correlated with the cognitive function and CSF levels of Aβ42 and t-tau. PF4 may become a promising anti-aging and therapeutic target for AD, which is worthy of further study.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112689"},"PeriodicalIF":3.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and time-course changes in hemodynamic and physical performance parameters following single and multiple resistance training sets in cognitively impaired individuals: A randomized crossover study","authors":"Nuno Fonseca ,&nbsp;Dulce Esteves ,&nbsp;Diogo Luís Marques ,&nbsp;Luís Brandão Faíl ,&nbsp;Tiago Sousa ,&nbsp;Mafalda Pamplona Pinto ,&nbsp;Henrique Pereira Neiva ,&nbsp;Mikel Izquierdo ,&nbsp;Mário Cardoso Marques","doi":"10.1016/j.exger.2025.112688","DOIUrl":"10.1016/j.exger.2025.112688","url":null,"abstract":"<div><div>This study analyzed the acute and time-course changes following one resistance training (RT) set (1SET) and three sets (3SET) on hemodynamic and physical performance parameters in individuals with different cognitive impairment levels. Thirty-nine individuals (22 women and 17 men aged 80 ± 9 years) grouped by cognitive impairment (mild [MILD], moderate [MOD], and severe [SEV]) randomly performed two protocols, each separated by one week, of 1SET or 3SET of 10 repetitions. Before (PRE), immediately (POST), and 72 h after (POST72) protocols, the participants performed the following measurements: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), 1-kg medicine ball throw (MBT) distance, five-repetition sit-to-stand (STS) time, and handgrip strength (HGS). A three-way ANOVA with repeated measures revealed no significant differences between 1SET and 3SET on SBP, DBP, HR, STS, MBT, and HGS in any group at any time (all <em>p</em> ≥ 0.05). SEV increased SBP and HR from PRE to POST and decreased STS time after 3SET. From POST to POST72, all groups decreased SBP after both protocols, and SEV improved STS time after 3SET and HGS following both protocols. Furthermore, from PRE to POST72, MILD decreased SBP, while SEV improved HGS following 1SET and STS time following 3SET. These findings demonstrate that single and multiple sets cause acute hemodynamic changes, with a tendency to reduce SBP within 72 h. Additionally, individuals with worse cognitive function showed greater adaptive responses over time in physical performance, with 1SET improving HGS and 3SET enhancing STS performance.</div><div>Trial registration: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> ID: <span><span>NCT06185010</span><svg><path></path></svg></span></div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112688"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China","authors":"Decheng Li ,&nbsp;Yunhe Wang ,&nbsp;Shuai Guo ,&nbsp;Ziyang Ren ,&nbsp;Binbin Su ,&nbsp;Lichuan Zhang ,&nbsp;Zuliyaer Talifu ,&nbsp;Xiaoying Zheng","doi":"10.1016/j.exger.2024.112656","DOIUrl":"10.1016/j.exger.2024.112656","url":null,"abstract":"<div><h3>Background</h3><div>Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.</div></div><div><h3>Methods</h3><div>We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). IC was evaluated across cognitive, locomotion, psychological, sensory, and vitality domains. Asymmetry and weakness were measured using the maximum value of HGS. Logistic regression models were employed to examine the association of the individual and combined groupings of HGS asymmetry and weakness with IC impairment (a total score ≥ 2 across five domains). The potential non-linear relationship was explored using a restricted cubic spline (RCS) model.</div></div><div><h3>Results</h3><div>Of the 4798 participants included (median age 66.0 years, IQR 63.0–71.0 years; 56.9 % male), 35.2 % had IC impairment. HGS asymmetry (<em>OR</em> = 1.26, 95 % <em>CI</em>: 1.11–1.43) and weakness (<em>OR</em> = 2.09, 95 % <em>CI</em>: 1.78–2.45) were both independent risk factors for IC impairment. Notably, participants experiencing both HGS asymmetry and weakness were at even higher risk of IC impairment (<em>OR</em> = 2.47, 95 % <em>CI</em>: 1.99–3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between HGS status and impairments in specific IC domains, particularly in locomotion. In contrast to other domains, it was the Weakness only group, rather than the Both group, that had the highest risk of vitality impairment. There was a U-shaped relationship between HGS asymmetry and IC impairment.</div></div><div><h3>Conclusions</h3><div>HGS asymmetry and weakness were associated with an increased risk of composite and individual domain IC impairment. Assessing and maintaining HGS symmetry and strength may have implications for the early identification of individuals at risk for IC impairment and the prevention of related adverse health outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112656"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}