Experimental gerontology最新文献

{"title":"Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community","authors":"Minjun Kim ,&nbsp;Inhwan Lee","doi":"10.1016/j.exger.2025.112737","DOIUrl":"10.1016/j.exger.2025.112737","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 community-dwelling older women and assess physical activity’s mediating role.</div></div><div><h3>Methods</h3><div>Body composition was assessed using dual-energy X-ray absorptiometry, and the android-to-gynoid (A/G) fat ratio was calculated as the android fat proportion divided by the gynoid fat proportion. Participants were categorized into high and low 50 % groups based on the A/G fat ratio. Dysmobility syndrome was defined as the presence of at least three of the following: increased body fat percentage, decreased muscle mass, osteoporosis, slow gait speed, reduced grip strength, or a history of falls. Cognitive impairment was defined as a Mini-Mental State Examination for Dementia Screening score ≤ 23. Physical activity was measured using the International Physical Activity Questionnaire, with ≥600 metabolic equivalent of task-minutes per week classified as active and &lt; 600 as inactive. Binary logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the A/G fat ratio and physical activity. The mediating effects of physical activity were analyzed using Process Macro Model 4.</div></div><div><h3>Results</h3><div>Participants in the low 50 % A/G fat ratio group had higher odds of dysmobility syndrome (crude OR = 3.500, <em>p</em> &lt; 0.001; adjusted OR = 3.678, <em>p</em> = 0.002) and cognitive impairment (crude OR = 2.714, <em>p</em> = 0.005; adjusted OR = 3.293, p = 0.005) than did those in the high 50 % group, even after covariate adjustments. The inactive group had higher odds of dysmobility syndrome (crude OR = 4.185, <em>p</em> &lt; 0.001; adjusted OR = 3.199, <em>p</em> = 0.005) and cognitive impairment (crude OR = 3.190, <em>p</em> = 0.001; adjusted OR = 2.551, <em>p</em> = 0.022) than did the active group. Mediation analysis indicated that physical activity partially mediated the association between the A/G fat ratio and dysmobility syndrome (indirect effect = −0.5099, 95 % CI = −0.9045 to −0.1786) and cognitive impairment (indirect effect = 0.1446, 95 % CI = 0.0554 to 0.2582).</div></div><div><h3>Conclusion</h3><div>A lower A/G fat ratio increases the risks of dysmobility syndrome and cognitive impairment in older women; physical activity may mitigate these effects.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112737"},"PeriodicalIF":3.9,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques","authors":"Ludwig A.P. Metzler ,&nbsp;Jeanette M. Metzger ,&nbsp;Keenan J. Gerred ,&nbsp;Marina E. Emborg ,&nbsp;Amita Kapoor","doi":"10.1016/j.exger.2025.112736","DOIUrl":"10.1016/j.exger.2025.112736","url":null,"abstract":"<div><div>As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related neurodegenerative disorders are increasingly important for identifying early diagnostic biomarkers, monitoring disease progression, and evaluating treatment responsiveness. Rhesus macaques are an ideal species for studies on neurodegeneration due to their phylogenetic relatedness to humans and their complex brain anatomy and physiology. Technological advances in assay sensitivity have facilitated the identification of blood-based biomarkers of neurodegeneration and inflammation in human populations. The aim of this study was to translate these methods for use in male and female rhesus macaques across adulthood. We collected plasma samples from 47 rhesus macaques representing pre-adult (1–5 years, <em>n</em> = 6 female, <em>n</em> = 5 male), young (5–7 years, n = 5 female, <em>n</em> = 7 male), middle (8–16 years, n = 7 female, n = 7 male), and older adult (17–22 years, n = 6 female, <em>n</em> = 4 male) subjects. Quantified biomarkers included neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid beta (Aβ42, Aβ40, and their ratio), total tau, phosphorylated tau (pTau181), interleukin (IL) 2, IL-6, IL-8, and IL-10. Plasma NfL and IL-6 levels were significantly increased with age in both sexes, with a marked rise during middle adulthood. The ratio of Aβ42/Aβ40 was significantly lower in the middle and older aged females compared to the youngest group. There was no effect of age or sex on total tau or pTau181 levels. Overall, these results demonstrate the feasibility of evaluating blood biomarkers of neurodegeneration and inflammation in rhesus macaques during adulthood.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112736"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related peculiarities of antibody-mediated humoral immune response following SARS-CoV-2 infection","authors":"M. Movsisyan ,&nbsp;H. Harutyunyan ,&nbsp;Kh. Movsisyan ,&nbsp;I. Kasparova ,&nbsp;A. Hakobyan ,&nbsp;K. Yenkoyan","doi":"10.1016/j.exger.2025.112735","DOIUrl":"10.1016/j.exger.2025.112735","url":null,"abstract":"<div><div>Thousands of articles were published about the COVID-19 disease and hundreds about the immune response. But still little is known about the features of SARS-CoV-2-specific immunity in elderly. The aim of current research was to evaluate the age-related peculiarities of antibody mediated humoral immune response following SARS-CoV-2 infection. Our study presents an intriguing divergence from the classical concept of immunosenescence, where aging has been assumed to cause poor antibody responses, reduced or inefficient vaccination, and overall blunted immune responses in elderly people. Our findings were opposite to some of these expectations; participants aged over 60 expressed elevated titers of anti-SARS-CoV-2 antibodies in comparison to younger adults. Analyzing the data of relative neutralization and avidity of anti-SARS-Cov-2 (S) antibodies we propose that although older adults produce a higher quantity of antibodies, their functional efficiency appears relatively reduced exhibiting lower neutralizing capacity and binding strength per antibody compared to younger adults. We can assume that the immune system of the elderly may require a higher level of antibody production to obtain a comparable level of protection. Our findings highlight the intricate nature of immune responses in convalescent older adults. This has particular relevance to understanding immunity and vaccine responses in different age groups.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112735"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age related gut microbiota regulates energy-related metabolism to influence natural aging phenotypes in the heart","authors":"Shufen Wu ,&nbsp;Lingran Qiao ,&nbsp;Haiyan Liu ,&nbsp;Yan-Li Li ,&nbsp;Rui Wang ,&nbsp;Yiru Yin ,&nbsp;Enhui Li ,&nbsp;Lele Wang ,&nbsp;Xiaoya Guan ,&nbsp;Litian Yin ,&nbsp;Qinghua Liu ,&nbsp;Xiaoyang Peng ,&nbsp;Yutong Zhang ,&nbsp;Zhuanfang Yang ,&nbsp;Lin Zuo ,&nbsp;Ce Zhang","doi":"10.1016/j.exger.2025.112734","DOIUrl":"10.1016/j.exger.2025.112734","url":null,"abstract":"<div><div>As the population ages, problems pertaining to health and life expectancy due to the aging heart have become increasingly prominent. The gut microbiota has become a potential therapeutic target in several diseases, including cardiovascular diseases. Current studies on the roles of the gut microbiota in the cardiovascular system have focused mainly on cardiovascular diseases; therefore, the effects of the gut microbiota on the natural aging of myocardial tissue remain unclear. The present study aimed to explore the roles and mechanisms of the gut microbiota and related metabolites in the natural aging of the heart. Animal models of fecal microbiota transplantation (FMT) were established in elderly and young rats. 16S rRNA sequencing revealed that the gut microbiota of the recipients shifted toward the profile of the donors, with concomitant cardiac structure and diastolic function changes detected via ultrasound and positron emission tomography–computed tomography (PET–CT). A group of significantly enriched myocardial metabolites detected by LC/MS were involved in the fatty acid β-oxidation process. Together with altered glucose uptake, as revealed by PET–CT, changes in ATP content and mitochondrial structure further verified a metabolic difference related to energy among rats transplanted with the gut microbiota from donors of different ages. This study demonstrated that gut microbes may participate in the physiological aging process of the rat heart by regulating oxidative stress and autophagy. The gut microbiota has been shown to be involved in the natural aging of the heart at multiple levels, from the organ level to the metabolically plastic myocardiocytes and associated molecules.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112734"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis","authors":"Qiang Ren ,&nbsp;Kaixi Ding ,&nbsp;Wei Jiang ,&nbsp;Wen Zhu ,&nbsp;Yongxiang Gao","doi":"10.1016/j.exger.2025.112729","DOIUrl":"10.1016/j.exger.2025.112729","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) promotes the onset and progression of sarcopenia, yet mechanisms of co-morbidity between RA and sarcopenia are under-explored. Therefore, this study integrated Gene Expression Omnibus (GEO) and Genome-wide association studies (GWAS) data to comprehensively identify shared genes, associated mechanisms, and biological pathways in RA and sarcopenia.</div></div><div><h3>Methods</h3><div>Utilizing two GEO datasets—GSE226151, which includes 60 RNA-seq samples of skeletal muscle from healthy aged, pre-sarcopenia, and sarcopenia individuals, and GSE55235, with 20 RNA-seq samples of synovial tissue from healthy and RA joints—we performed differentially expressed genes analysis, weighted gene co-expression network analysis to identify crosstalk genes in RA and sarcopenia, and enrichment analysis for these genes. Using relevant GWAS datasets, SMR analyses and cis-eQTL analyses were performed. We further validated and identified key crosstalk genes and explored potential causal associations between key crosstalk genes and RA and sarcopenia-related traits.</div></div><div><h3>Results</h3><div>We identified 25 crosstalk genes shared between RA and sarcopenia, which are involved in immune-inflammatory response pathways, including neutrophil extracellular trap formation and Fc gamma receptor-mediated phagocytosis. SMR analysis further identified six core crosstalk genes: NCF1, FCGR2A, FCGR3A, SORL1, FCGR3B, and ITGAX (<em>P</em>_<em>SMR</em> &lt; 0.05). <em>cis</em>-eQTL analysis showed that FCGR2A might have a negative causal association with appendicular lean mass, whole body fat-free mass, and a positive causal association with RA (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Overall, this study is the first to reveal the molecular crosstalk between RA and sarcopenia, identifying 25 shared genes and key immune-inflammatory response-related pathways. Further SMR and cis-eQTL analyses were conducted to validate six core genes, with FCGR2A emerging as a potential drug target for RA-associated sarcopenia. These findings provide new insights into the comorbid mechanisms of RA and sarcopenia, offering potential therapeutic targets for both conditions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112729"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional role of circular RNA XYLT1 in vascular remodeling and oxidative stress in aging","authors":"Fahimeh Varzideh ,&nbsp;Pasquale Mone ,&nbsp;Urna Kansakar ,&nbsp;Gaetano Santulli","doi":"10.1016/j.exger.2025.112728","DOIUrl":"10.1016/j.exger.2025.112728","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112728"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of cognitive and emotional factors on motor dual-task performance in nursing home residents. The mediating and moderating roles of cognition, concerns about falling, well-being, and depressive symptoms. A cross-sectional observational study","authors":"Thomas Jürgen Klotzbier ,&nbsp;Julian Rudisch ,&nbsp;Nadja Schott ,&nbsp;Oliver Vogel ,&nbsp;Thomas Cordes ,&nbsp;Claudia Voelcker-Rehage ,&nbsp;Bettina Wollesen","doi":"10.1016/j.exger.2025.112726","DOIUrl":"10.1016/j.exger.2025.112726","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed (1) to compare walking performance under single (ST) and dual-task (DT) conditions with varying cognitive tasks and degrees of difficulty, (2) to investigate the association of concerns about falling, depressive symptomatology, and psychological and physical well-being with ST and DT walking performance as well as cognitive and motor DT costs (cDTC; mDTC); and (3) to examine whether depressive symptomatology and well-being mediate or moderate the association between concerns about falling and DT performance in a large sample of German nursing home residents.</div></div><div><h3>Methods</h3><div>We analyzed data from a cross-sectional study with 449 ambulatory nursing home residents (mean age 84.1 ± 7.87 years). Performance on three cognitive tasks with different cognitive loads (serial subtraction in one's [SST_1] and three's [SST_3]; verbal fluency [VFT]; number of correctly reproduced responses) and (walking speed) was recorded each under ST and DT conditions (walking plus additional cognitive task). In addition, we assessed concerns about falling, depressive symptomatology, and psychological and physical well-being using the Falls Efficacy Scale – International (FESI), the Center for Epidemiologic Studies Depression Scale (CESD), and the Short-Form-Health Survey (SF-12), respectively.</div></div><div><h3>Results</h3><div>We observed significant differences in ST walking and walking while performing an additional cognitive task. Walking speed was higher in ST walking than walking during the SST_1, SST_3, and VFT (all <em>p</em> &lt; 0.001). In both the ST walking and the SST_1 DT condition, the concerns about falling (and physical well-being) explained a low proportion of variance in walking speed. Physical well-being had a minor but significant mediating effect on the relationship between concerns about falling and walking speed in the ST walking and SST_1 DT condition.</div></div><div><h3>Conclusions</h3><div>Concerns about falling and physical well-being seem to exert a small yet statistically significant effect on ST walking under conditions of lower cognitive demand. The effect is diminished by increasing the cognitive load, as compensation becomes impossible. Interventions focusing on decreasing concerns about falling and maintaining physical well-being might compensate for limitations in walking performance of nursing home residents in ST and DT situations. Reducing fall concerns, promoting physical well-being, and adjusting cognitive demands can improve nursing home residents' walking performance.</div></div><div><h3>Trials registration</h3><div>DRKS00014957 (BfArM - Deutsches Register Klinischer Studien (DRKS)).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112726"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the oral microbiome, number of teeth and frailty among American adults: A cross-sectional study from NHANES 2009–2012","authors":"Sixiang Yang ,&nbsp;Yanyun He ,&nbsp;Yuping Ma ,&nbsp;Ruoli Wang ,&nbsp;Yeke Wu ,&nbsp;Wenbin Wu","doi":"10.1016/j.exger.2025.112727","DOIUrl":"10.1016/j.exger.2025.112727","url":null,"abstract":"<div><h3>Background</h3><div>The intricate interrelationship between oral health, the number of teeth, oral microbiota, and frailty remains largely unexplored in clinical research. This study aimed to investigate the interrelationship between oral microbiome, the number of teeth, and frailty.</div></div><div><h3>Methods</h3><div>Data from 4518 participants in NHANES 2009–2012 were analyzed. Frailty was measured using the 48-item Frailty Index (FI). Multivariable logistic regression and restricted cubic spline (RCS) evaluated associations between alpha diversity and frailty. Mediation analysis was used to assess the role of number of teeth. The associations between oral microbiome diveristy and mortality were analyzed by Cox regression. Beta diversity was examined with PCoA and PERMANOVA.</div></div><div><h3>Results</h3><div>The prevalence of frailty was 39.73 %. Univariate analysis showed that alpha diversity indices except for the Simpson index were significantly lower in frailty, and after adjusted for confounders, observed ASVs (adjusted OR: 0.80 [0.73, 0.87], <em>p</em> &lt; 0.001), Faith's PD (adjusted OR: 0.81 [0.74, 0.88], <em>p</em> &lt; 0.001) and Shannon-Weiner index (adjusted OR: 0.88 [0.81, 0.95], <em>p</em> = 0.002) were remained significantly associated with frailty. The reduced number of teeth partially mediated the relationship (for Faith's PD: β_indirect = −0.001 [−0.003, 0.000], <em>p</em> = 0.036, proportion: 8.33 % [0.00 %, 37.50 %]; for Shannon-Weiner index, β_indirect = −0.007 [−0.013, −0.002], <em>p</em> = 0.007, Proportion = 17.07 % [3.39 %, 65.00 %]). Univariable Cox proportional hazard regression showed that all alpha diversity indices were significantly associated with all-cause mortality in frail population, and in multivariable analysis, Shannon-Weiner index (HR: 0.72 [0.55, 0.94], <em>p</em> = 0.017) and Simpson index (HR: 0.71 [0.60, 0.83], <em>p</em> &lt; 0.001) remained statistically significant. PCoA showed that beta diversity was also significantly associated with frailty.</div></div><div><h3>Conclusion</h3><div>Lower oral microbiome diversity is associated with higher frailty and mortality. The number of teeth partially mediates this link, emphasizing the importance of oral health in mitigating frailty and promoting healthy aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112727"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into EIF6 as a target of Apigenin in alleviating chondrocyte senescence","authors":"Erliang Li ,&nbsp;Hui Yu ,&nbsp;Xin Xu ,&nbsp;Min Wang ,&nbsp;Mingyi Yang ,&nbsp;Zhi Yang ,&nbsp;Peng Xu","doi":"10.1016/j.exger.2025.112725","DOIUrl":"10.1016/j.exger.2025.112725","url":null,"abstract":"<div><h3>Purpose</h3><div>Apigenin, a flavonoid found in edible plants, has demonstrated therapeutic potential in various diseases, but its role in knee osteoarthritis (KOA) remains unclear. This study aimed to identify the potential targets and mechanisms of Apigenin in KOA.</div></div><div><h3>Methods</h3><div>Network pharmacology analysis identified 80 targets of Apigenin, of which 48 overlapped with KOA-related targets. Summary-data-based Mendelian randomization (SMR) analysis and molecular docking were utilized to explore key target genes. Single-cell RNA sequencing data from human cartilage tissue and in vitro studies using SW1353 cells treated with 3 % hydrogen peroxide (H2O2) were analyzed to validate findings.</div></div><div><h3>Results</h3><div>SMR analysis identified EIF6 as a potential target of Apigenin in KOA, negatively associated with disease progression. Molecular docking revealed strong binding affinity between Apigenin and EIF6. Single-cell analysis suggested downregulation of EIF6 may contribute to chondrocyte senescence. In vitro, Apigenin (20 μM) reversed H2O2-induced senescence and increased EIF6 expression in SW1353 cells, improving cell viability.</div></div><div><h3>Conclusion</h3><div>Apigenin upregulates EIF6 expression and mitigates H2O2-induced chondrocyte senescence, highlighting its potential as a therapeutic agent for KOA. These findings provide insights into the nutritional health benefits of Apigenin and its implications for KOA treatment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112725"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity classified by anthropometric parameters was associated with mitochondrial bioenergetics impairment of peripheral blood mononuclear cells in the elderly population","authors":"Tanawat Attachaipanich ,&nbsp;Sirawit Sriwichaiin ,&nbsp;Nattayaporn Apaijai ,&nbsp;Thanaphat Thanyaratsarun ,&nbsp;Nisakron Thongmung ,&nbsp;Prin Vathesatogkit ,&nbsp;Piyamitr Sritara ,&nbsp;Nipon Chattipakorn ,&nbsp;Chagriya Kitiyakara ,&nbsp;Siriporn C. Chattipakorn","doi":"10.1016/j.exger.2025.112724","DOIUrl":"10.1016/j.exger.2025.112724","url":null,"abstract":"<div><div>Waist circumference (WC), waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR), even in individuals who have a normal body mass index (BMI), are correlated with cardiovascular events. The aim of this study is to establish the association between obesity and mitochondrial bioenergetics in peripheral blood mononuclear cells (PBMCs). The study included 1584 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. The mean age of participants in this study was 68.4 years. There was 24.2 % diabetes mellitus (DM) with a mean HbA1c level of 6.8. WC, WHR, and WHtR were associated with decreased basal, maximal respiration, spare respiratory capacity (SRC), and ATP production, whereas BMI was only associated with reduced maximal respiration and SRC. We further stratified the participants into four groups based on obesity classified by WHR and DM status: Non-DM/Non-obese (<em>n</em> = 468), Non-DM/Obese (<em>n</em> = 733), DM/Non-obese (<em>n</em> = 84), and DM/Obese (<em>n</em> = 299). Both obesity and DM were associated with mitochondrial bioenergetic impairment and increased mitochondrial oxidative stress. Interestingly, there was no difference in mitochondrial bioenergetics impairment between non-DM/Obese and DM participants. Our study demonstrated that WC, WHR, and WHtR better reflected underlying mitochondrial dysfunction in PBMCs compared to BMI. Furthermore, obesity was associated with mitochondrial dysfunction to the same degree as DM.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"202 ","pages":"Article 112724"},"PeriodicalIF":3.9,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}