Experimental gerontology最新文献

{"title":"Association between weight-adjusted waist index (WWI) and multimorbidity: Evidence from NHANES and prospective validation in CHARLS","authors":"Xiaorong Ye , Dingqi Shi , Ruixuan Li , Yuxin Li , Luwen Zhang , Lei Shi , Yao Xiao","doi":"10.1016/j.exger.2026.113044","DOIUrl":"10.1016/j.exger.2026.113044","url":null,"abstract":"<div><h3>Background</h3><div>The burden of chronic diseases is known to be significantly increased by obesity, yet conventional measures like waist circumference (WC) and body mass index (BMI) do not accurately capture central adiposity. The Weight-Adjusted Waist Index (WWI), calculated as waist circumference (cm)/√weight (kg), has been proposed to assess abdominal fat distribution independent of overall body size and may theoretically outperform BMI and WC by reducing muscle-mass–related misclassification. Evidence regarding its association with multimorbidity remains limited. This study sought to elucidate these associations using nationally representative NHANES data and to verify the results in a prospective Chinese cohort (CHARLS).</div></div><div><h3>Method</h3><div>Adults ≥20 years in NHANES 2017–2023 were included, applying sampling weights. Multimorbidity was defined as the coexistence of ≥2 chronic conditions, identified based on self-reported physician-diagnosed diseases in both NHANES and CHARLS. In NHANES, multivariable logistic regression, RCS, GAM, interaction analysis and Sensitivity analyses were performed, adjusting for demographics, socioeconomic status, lifestyle behaviors, and dietary factors. ROC curve analysis was then performed to evaluate and compare the predictive performance of WWI, BMI, and WC. WWI, BMI, and WC were analyzed in separate regression models to avoid multicollinearity interference when comparing predictive performance. External validation was conducted using Cox regression and RCS in CHARLS 2011–2028, adjusting for demographic, socioeconomic, and lifestyle variables.</div></div><div><h3>Result</h3><div>In NHANES, WWI was significantly positively associated with multimorbidity (OR = 1.74; 95% CI: 1.59–1.90; <em>P</em> < 0.001). Participants in the highest quartile of WWI had over threefold higher odds of multimorbidity compared with those in the lowest quartile (OR = 3.04; 95% CI: 2.94–3.73; P < 0.001). RCS indicated a predominantly linear association, while GAM suggested a modest J-shaped pattern. Sex significantly modified the association (P for interaction <0.05). Sensitivity analysis in adults ≥45 years yielded consistent results. In the CHARLS cohort (<em>n</em> = 2985), higher WWI significantly predicted incident multimorbidity (HR = 1.14; 95% CI: 1.06–1.22). WWI showed the highest discriminative ability for multimorbidity (AUC = 0.709) compared with BMI and WC.</div></div><div><h3>Conclusions</h3><div>WWI remained a significant and consistent predictor of multimorbidity, demonstrating greater discriminatory ability than BMI or WC. While RCS suggested a predominantly linear association, GAM revealed potential non-linearity at extreme WWI levels, indicating that dose-response patterns warrant further confirmation. Validation in the CHARLS cohort supports temporal association, offering greater causal plausibility. Collectively, these results highlight WWI as a practical marker for identifying h","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"215 ","pages":"Article 113044"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation","authors":"Yan Lv ,&nbsp;Yongjun Du ,&nbsp;Peng Lin ,&nbsp;Jiamian Liu ,&nbsp;Shaoquan Pu ,&nbsp;Sheng Lu","doi":"10.1016/j.exger.2026.113033","DOIUrl":"10.1016/j.exger.2026.113033","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis and sarcopenia are age-related degenerative diseases that frequently co-occur in the older adults, yet their shared molecular mechanisms remain poorly understood. This study aimed to identify common biomarkers.</div></div><div><h3>Methods</h3><div>By utilizing the GEO database, differential and enrichment analyses were conducted to identify genes that are commonly expressed in both diseases. Subsequently, key genes were identified through four types of machine learning and six types of immune infiltration analyses. Finally, the Dual Condition Sarcopenia and Osteoporosis (DSO) model was established by combining bilateral ovariectomy with natural aging to validate the key genes.</div></div><div><h3>Results</h3><div>A total of 577 and 625 genes were identified in the osteoporosis (GSE156508) and sarcopenia (GSE226151), respectively. GO, KEGG, and GSEA analyses revealed that osteoporosis-related genes were enriched in muscle development and myogenesis pathways, while sarcopenia-related genes were linked to osteoclast differentiation and inflammatory responses. Venn analysis identified 20 genes shared by both diseases. Four machine learning algorithms identified five key genes: APOC1, ENPP5, FBXL22, IRS1, and PAQR4. Among them, PAQR4 showed the highest predictive value in ROC analysis and was consistently downregulated in both training and validation datasets. Immune infiltration analysis indicated altered neutrophil levels, notably reduced in osteoporotic skeletal muscle. Experimental validation confirmed decreased PAQR4 expression in both bone and muscle tissues of the DSO model.</div></div><div><h3>Conclusions</h3><div>These findings highlight PAQR4 as a potential biomarker and a candidate molecule of interest for osteosarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113033"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of remnant cholesterol inflammatory index for cardiovascular-kidney-metabolic syndrome progression: A prospective cohort study","authors":"Xiaoying Ren ,&nbsp;Yong Tian ,&nbsp;Juan Tian ,&nbsp;Guang Wang ,&nbsp;Jia Liu","doi":"10.1016/j.exger.2026.113030","DOIUrl":"10.1016/j.exger.2026.113030","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular-kidney-metabolic (CKM) syndrome is a progressive disorder resulting from the intricate interactions among obesity, diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD). Remnant cholesterol (RC) has been shown to be associated with the risk of CKM syndrome progression. However, the combined effects of RC and high-sensitivity C-reactive protein (hs-CRP) on CKM syndrome progression remain unclear. This study evaluated the association between the remnant cholesterol inflammatory index (RCII) and CKM progression risk.</div></div><div><h3>Methods</h3><div>Data from the China Health and Retirement Longitudinal Study (CHARLS) were analyzed. Logistic regression models were employed to investigate the association between the baseline RCII and advanced CKM stages. Kaplan-Meier analysis was conducted to assess the cumulative incidence of CVD across RCII quartiles in individuals with CKM stages 0–3. Cox regression models were used to examine the associations of the baseline RCII and cumulative RCII (CumRCII) with the risk of new-onset CVD among individuals with CKM stages 0–3.</div></div><div><h3>Results</h3><div>In the baseline analysis, each standard deviation (SD) increase in the RCII was associated with a 26% greater risk of advanced CKM stages (odds ratio (OR): 1.26, 95% CI: 1.20–1.34). During the 7-year follow-up, 1483 (21.5%) participants with CKM stages 0–3 developed CVD. The cumulative incidence of CVD progressively increased across RCII quartiles, from 17.02% in Q1 to 25.75% in Q4. After full adjustment, compared with that in RCII Q1, CVD risk was 19% greater in RCII Q3 (hazard ratio (HR): 1.19, 95% CI: 1.02–1.39) and 29% greater in RCII Q4 (HR: 1.29, 95% CI: 1.11–1.51). Participants with CumRCII levels that exceeded 29.49 had a significantly increased risk of new-onset CVD (HR: 1.41, 95% CI: 1.10–1.80).</div></div><div><h3>Conclusions</h3><div>Higher baseline RCII and CumRCII were associated with an increased CVD risk in participants with CKM stages 0<strong>–</strong>3. Early intervention in those with elevated RCII may help prevent CKM progression.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113030"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle–brain axis mechanisms linking community-based exercise to cognitive function in older adults: A five-arm randomized controlled trial","authors":"Jiadong Qiu ,&nbsp;Xiongying Song ,&nbsp;Jian Wang ,&nbsp;Sungmin Kim","doi":"10.1016/j.exger.2026.113041","DOIUrl":"10.1016/j.exger.2026.113041","url":null,"abstract":"<div><h3>Objective</h3><div>To compare community-feasible exercise effects on cognition and explore muscle–brain axis mechanisms in older adults.</div></div><div><h3>Methods</h3><div>In this a single-blind, five-arm randomized controlled trial, participants were allocated to 12-form Chen-style Tai Chi (CTC12), 24-form Yang-style Tai Chi (TC24), square dancing (SD), walking, or control for 12 weeks (two sessions/week). Global cognition was assessed using Beijing Chinese MoCA. Body composition was evaluated using multifrequency bioimpedance: skeletal muscle mass (SMM), fat mass (FM), total body water, protein mass and basal metabolic rate (BMR). Physical performance was assessed using Short Physical Performance Battery (SPPB), maximal handgrip strength (HGS). Fasting interleukin-6 (IL-6) levels and other blood biomarkers were also measured.</div></div><div><h3>Results</h3><div>113 participants completed the intervention (mean age 62.3 years; 79.6% female). After 12 weeks training, MoCA scores were improved in CTC12 group (<em>n</em> = 22, Δ = +0.46, <em>p</em> = 0.0045) and SD group (n = 22, Δ = +0.50, <em>p</em> = 0.0046), with no change in TC24 group (<em>n</em> = 23), walking group (n = 23), and control group (n = 23). Physiologically, CTC12 group increased SMM and BMR with small SPPB/HGS gains and showed a significant reduction in IL-6 levels; SD group reduced BMI and FM and increased BMR and SPPB; TC24 group increased BMR only; walking showed no measurable changes. For correlation analyses, ΔMoCA was positively associated with ΔSMM (<em>p</em> = 0.014) and ΔBMR (<em>p</em> = 0.004) in the CTC12 group, and negatively associated with ΔBMI (<em>p</em> = 0.002) and ΔFM (p = 0.002) in the SD group.</div></div><div><h3>Conclusions</h3><div>CTC12, SD were associated with modest cognitive gains and distinct physiological patterns potentially linked to the muscle–brain axis, which may help guide exercise choices for older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113041"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do myokines influence the associations between sarcopenia-related parameters and cognitive function in community-dwelling older adults: exploratory results from the ENHANce study","authors":"Nadjia Amini ,&nbsp;Laurence Lapauw ,&nbsp;Jolan Dupont ,&nbsp;Laura Vercauteren ,&nbsp;Sebastiaan Dalle ,&nbsp;Katrien Koppo ,&nbsp;Sabine Verschueren ,&nbsp;Jos Tournoy ,&nbsp;Evelien Gielen","doi":"10.1016/j.exger.2026.113042","DOIUrl":"10.1016/j.exger.2026.113042","url":null,"abstract":"<div><h3>Background</h3><div>Studies have shown that sarcopenia and its related parameters are associated with cognition. Preclinical evidence suggests that myokines, such as irisin, Brain-Derived Neurotrophic Factor(BDNF), myostatin and Insulin-like Growth Factor-1(IGF-1) might explain this relationship. This study aimed to explore the associations between sarcopenia-related parameters and cognition, and whether myokines influence this association.</div></div><div><h3>Methods</h3><div>Exploratory, cross-sectional analysis of data from the Exercise and Nutrition for Healthy AgeiNg (ENHANce,<span><span>NCT03649698</span><svg><path></path></svg></span>) study. Participants were older adults(≥65 years) with EWGSOP2-defined sarcopenia. Cognitive functioning was assessed by Mini-Mental State Examination(MMSE), Repeatable Battery for the Assessment of Neuropsychological Status(RBANS), Trail Making Test A&amp;B(TMT), Stroop and Maze Test. Sarcopenia-related parameters were measured: Handgrip Strength, Chair Stand Test, appendicular Lean Mass(aLM), Gait Speed (GS) and Short Physical Performance Battery(SPPB). Serum myokines(IGF-1, irisin, myostatin, BDNF) were determined through ELISA. Associations between cognition and sarcopenia-related parameters were analyzed using multivariable regression, adjusting for potential confounders including myokines.</div></div><div><h3>Results</h3><div>Fifty-eight participants were included in this analysis (76.2 ± 6.7 years, ♀:65.5%). After adjustment for age, sex, body mass index, aLM was associated with MMSE(β = 0.193,<em>p</em> = 0.012), RBANS Total(β = 0.196,<em>p</em> = 0.007) and RBANS Attention(β = 0.215,<em>p</em> = 0.002), CST was associated with RBANS Language(β = −0.314,<em>p</em> = 0.030), SPPB was associated with Maze time(β = −0.364,<em>p</em> = 0.004) and TMT-B (β = −0.333,<em>p</em> = 0.013) and GS was associated with TMT-A(β = −0.324,<em>p</em> = 0.045). After adjustments for BDNF&amp; IGF-1, the association between GS and TMT-A became non-significant. Irisin and myostatin did not influence the sarcopenia-cognition associations.</div></div><div><h3>Conclusion</h3><div>Sarcopenia-related parameters are associated with global and specific cognitive domains. BDNF may, partially, explain the association between muscle mass and MMSE. Additional research with larger sample size is needed to confirm these findings.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113042"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length and metabolic dysfunction-associated steatotic liver disease risk and progression: A systematic review and meta-analysis","authors":"Chunfeng Sun ,&nbsp;Ping Qiu ,&nbsp;Shuo Huang ,&nbsp;Qihan Luo ,&nbsp;Qing Ma ,&nbsp;Piao Hu ,&nbsp;Fangming Chen ,&nbsp;Hongyan Wu ,&nbsp;Chunxiao Chen","doi":"10.1016/j.exger.2026.113036","DOIUrl":"10.1016/j.exger.2026.113036","url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to systematically review existing literature to evaluate the association between telomere length (TL) and the risk of MASLD and its progression outcomes.</div></div><div><h3>Materials and methods</h3><div>PubMed, EMBASE, and Web of Science were searched for relevant studies up to May 27, 2025. Included studies were systematically reviewed to summarize the findings, with complementary quantitative analyses conducted using a random-effects model. This study was conducted in strict accordance with the PRISMA 2020 statement and was registered on the PROSPERO platform (CRD420251042478).</div></div><div><h3>Results</h3><div>Ultimately, 12 observational studies met the inclusion criteria. A limited number of high-quality cohort studies have consistently observed an association between shorter leukocyte TL (LTL) and an increased risk of MASLD. Evidence from cross-sectional studies appears more inconsistent and imprecise. Notably, cross-sectional analysis revealed a paradoxical increase in LTL among T2DM patients with MASLD, possibly reflecting a compensatory response to early-stage metabolic stress and insulin resistance; however, longitudinal evidence clarified that accelerated LTL attrition, rather than baseline length, serves as the critical driver and predictor of MASLD incidence. Despite consistent evidence indicating that shorter LTL may serve as a biomarker for severe MASLD progression, the interpretation of these findings is hampered by methodological limitations in current studies.</div></div><div><h3>Conclusion</h3><div>Current evidence suggests that shorter TL is a potential marker for MASLD risk, particularly supported by high-quality longitudinal data. While further quantitative analysis identified significant associations, the robustness of these results is compromised by the limited number of high-quality studies, alongside substantial heterogeneity and publication bias. Shorter TL may be associated with the adverse progression of MASLD. Future high-quality longitudinal studies are warranted to strengthen the body of evidence and establish their clinical utility.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113036"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between changes in intrinsic capacity of older adults in Chinese communities and adverse health-related outcomes: A prospective longitudinal Cohort study","authors":"Yaru Zhou ,&nbsp;Wenhua Yu ,&nbsp;Xiaohong Liu","doi":"10.1016/j.exger.2025.113008","DOIUrl":"10.1016/j.exger.2025.113008","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Preserving intrinsic capacity (IC) is essential for healthy aging. This study examined the associations between longitudinal changes in IC and subsequent adverse health outcomes.</div></div><div><h3>Methods</h3><div>Participants were community-dwelling adults aged ≥60 years from the China Health and Retirement Longitudinal Study (CHARLS). Changes in IC between 2011 and 2013 were classified as consistently well, improved, worsened, or consistently declined. Logistic regression assessed associations with falls and hospitalization (2015), and Cox models evaluated all-cause mortality (2020).</div></div><div><h3>Results</h3><div>Changes in IC were significant predictors of adverse outcomes. Worsened (OR = 1.674, 95 % CI: 1.163–2.411, <em>P</em> = 0.006) and consistently declined changes in IC (OR = 1.914, 95 % CI: 1.373–2.668, <em>P</em> &lt; 0.001) were both associated with an increased risk of falls, while domain-specific changes, such as worsened locomotion, consistently declined in cognition and fluctuations in psychology or vision, were also linked to increased fall risk (all <em>P</em> &lt; 0.017). Both consistently declined IC (OR = 1.513, 95 % CI: 1.079–2.122, P &lt; 0.017) and worsened locomotion were independent predictors of hospitalization (OR = 1.837, 95 % CI: 1.265–2.670, <em>P</em> = 0.001). Declines in locomotion were also strongly associated with mortality, with higher risk observed in the worsened group (HR = 1.571, 95 % CI: 1.088–2.267, <em>P</em> &lt; 0.017).</div></div><div><h3>Conclusions</h3><div>Monitoring intrinsic capacity changes, especially locomotion decline, enables early identification of vulnerable older adults and supports timely, targeted interventions to reduce adverse outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113008"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin and the muscle–brain axis: Mechanisms and translational potential","authors":"Beatrice Arosio ,&nbsp;Anna Picca","doi":"10.1016/j.exger.2026.113028","DOIUrl":"10.1016/j.exger.2026.113028","url":null,"abstract":"<div><div>The muscle–brain axis integrates peripheral metabolic activity with central nervous system function. Among the endocrine signaling molecules regulating such crosstalk, the peptide hormone irisin released during muscle contraction seems to play relevant roles. Irisin is generated by the proteolytic cleavage of the fibronectin type III domain-containing protein 5 and has emerged as a key regulator of neurotrophic and metabolic adaptation. Although initially described as a myokine, irisin is also expressed in adipose and neural tissues, acting through autocrine, paracrine, and endocrine mechanisms. Irisin binds to the αV/β5 integrin receptor complex and activates a network of signaling pathways which promote mitochondrial biogenesis, autophagy, oxidative stress resistance, and modulation of inflammatory responses. Within the central nervous system, irisin induces brain-derived neurotrophic factor expression and contributes to synaptic plasticity, neurogenesis, and cognitive preservation. Experimental models show that irisin reduces amyloid burden, limits α-synuclein pathology, suppresses neuroinflammation, and stabilizes blood–brain barrier integrity, supporting a disease-modifying role in neurodegenerative conditions. In skeletal muscle, irisin stimulates myogenesis, enhances anabolic signaling, and improves metabolic efficiency, suggesting broader relevance for sarcopenia and age-related metabolic decline. Herein, we discuss irisin as a promising biomarker and a candidate therapeutic target for disorders characterized by concurrent muscle deterioration and cognitive impairment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113028"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of grip indicators with post-discharge recovery in geriatric and hip fracture inpatients","authors":"Myrthe Swart ,&nbsp;Merle Geerds ,&nbsp;Ivan Bautmans ,&nbsp;Liza De Dobbeleer ,&nbsp;Siddharta Lieten ,&nbsp;Hugo Plácido da Silva ,&nbsp;Rudi Tielemans ,&nbsp;Cindel Bonneux ,&nbsp;Yvonne Schoon ,&nbsp;Geeske Peeters ,&nbsp;Marcel Olde Rikkert ,&nbsp;Dieuwke van Dartel ,&nbsp;René Melis","doi":"10.1016/j.exger.2025.113014","DOIUrl":"10.1016/j.exger.2025.113014","url":null,"abstract":"<div><h3>Objectives</h3><div>Hand grip measures offer potential indicators for recovery after hospitalization in older adults. We investigated prospective associations of the grip indicators maximal grip strength (GSmax), fatigue resistance (FR) and grip work (GW) with post-discharge functional limitations, health-related quality of life (HRQOL) and survival in older inpatients.</div></div><div><h3>Methods</h3><div>Grip indicators were evaluated at admission in general geriatric inpatients (GGI, <em>n</em> = 149) and geriatric hip fracture inpatients (HIP, <em>n</em> = 109). Questionnaires on functional limitations (10–40, lower is better) were collected for two weeks pre-admission, admission, three months follow-up, and six months follow-up. HRQOL (−4–10, higher is better) was assessed at admission, three months follow-up and six months follow-up. With individual growth modeling, we established the associations between grip indicators and the outcome trajectories. Three-month survival was analyzed using Cox proportional hazards models.</div></div><div><h3>Results</h3><div>In GGI, higher FR and GW were associated with better functional recovery from admission to three months follow-up (FR: B = −1.0 points per 10s increase, 95 %CI −1.9, −0.14; GW: B = −0.33 points per 100 kPa × s increase, 95 %CI −0.59, −0.07). HIP with higher grip indicators showed a better functional recovery towards three months follow-up (GSmax: B = −2.4 per 10 kPa increase, 95 %CI −3.9, −0.89; FR: B = −1.1, 95 %CI −2.4, 0.20; GW: B = −0.31, 95 %CI −0.61, −0.02). No or weak associations were found between grip indicators and HRQOL recovery. Hazard ratios pointed towards a better survival for better scores on grip indicators, but associations were not statistically significant.</div></div><div><h3>Conclusion</h3><div>Higher FR and GW at admission were associated with better recovery post-discharge in geriatric inpatients. Future research should examine the added clinical value of grip indicators in addition to known patient characteristics.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113014"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity–frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study","authors":"Stefano Cacciatore ,&nbsp;Riccardo Calvani ,&nbsp;Konstantinos Prokopidis ,&nbsp;Mathias Schlögl ,&nbsp;Andrea Russo ,&nbsp;Matteo Tosato ,&nbsp;Stephen D. Anton ,&nbsp;Christiaan Leeuwenburgh ,&nbsp;John A. Batsis ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi","doi":"10.1016/j.exger.2026.113026","DOIUrl":"10.1016/j.exger.2026.113026","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC–frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.</div></div><div><h3>Methods</h3><div>IC was assessed across five domains (locomotion, cognition, vitality, psychological well-being, and sensory function), rescaled to a 0–100 range, and combined with frailty status to define four IC–frailty phenotypes (concordant frail, discordant low IC, discordant high IC, concordant robust). Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured, and a composite inflammatory burden score (0–3) was derived.</div></div><div><h3>Results</h3><div>The analysis included 311 participants (mean age 85.4 ± 4.7 years, 66.6 % women). Median CRP, IL-6, and TNF-α levels increased progressively from concordant robust to concordant frail groups (<em>p</em> &lt; 0.01). In the fully adjusted model, concordant frail participants had higher inflammation compared with concordant robust (β = 0.71; 95 % CI 0.04–1.37; <em>p</em> = 0.03), while discordant high IC and discordant low IC showed intermediate values without statistical significance. A significant linear trend was observed across ordered phenotypes (β per category increment = 0.21, 95 % CI 0.06 to 0.37). Locomotion and vitality emerged as the domains most strongly linked to inflammation.</div></div><div><h3>Conclusions</h3><div>IC–frailty phenotypes show a biological gradient of subclinical inflammation, with higher IC having lower inflammation levels. Preserved locomotion reflects key functional correlates of resilience and vitality in advanced age.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113026"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}