Experimental gerontology最新文献

{"title":"Age and sex modulate scapular muscle excitation strategies during loaded shoulder flexion.","authors":"Josée Rochon, Sarah Bohunicky, Trisha Scribbans","doi":"10.1016/j.exger.2025.112897","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112897","url":null,"abstract":"<p><p>Age and sex are primary risk factors for shoulder pain, yet the underlying neuromuscular adaptations in scapular control are poorly understood, partly due to methodological inconsistencies in prior research, particularly in load standardization. This study aimed to define age- and sex-related differences in scapular muscle excitation during a shoulder flexion task with a standardized relative load. Fifty-two healthy younger (18-39y) and older (60-74y) males and females performed shoulder flexion against a load equivalent to 30 % of their maximal strength. High-density and bipolar surface electromyography (EMG) quantified the excitation magnitude (%MVIC) and time-to-peak (%TTP) of the serratus anterior (SA), and upper, middle, and lower trapezius (UT, MT, LT). Compared to younger adults, older adults demonstrated significantly greater SA excitation magnitude (p = 0.044) and a delayed time to peak SA excitation (p = 0.002). Separately, females exhibited significantly greater LT excitation than males (p = 0.033). No significant differences were observed for the UT or MT muscles between any groups. Our findings reveal distinct neuromuscular strategies that are dependent on age and sex. The greater and delayed SA excitation in older adults may be a critical compensatory mechanism to preserve shoulder function in the face of age-related neuromuscular decline. Similarly, the heightened LT excitation in females points to a sex-specific motor control strategy. By using a standardized relative load, this study clarifies conflicting reports in the literature and provides novel insights into the adaptive neuromuscular patterns that may influence long-term shoulder health.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112897"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-conventional lipid parameters predict the risk of rapid kidney function decline in patients with cardiovascular-kidney-metabolic syndrome: The first cohort study evidence from CHARLS","authors":"Mengying Dong ,&nbsp;Xueqi Chen ,&nbsp;Jiangen Liu ,&nbsp;Chunjian Li","doi":"10.1016/j.exger.2025.112892","DOIUrl":"10.1016/j.exger.2025.112892","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluates the predictive value of three novel lipid-derived biomarkers: non-HDL-to-HDL cholesterol ratio (NHHR); natural logarithm of remnant cholesterol (lnRC); and cholesterol, high-density lipoprotein, and glucose index (CHG) for rapid kidney function decline (RKFD) in patients with cardiovascular-kidney-metabolic (CKM) syndrome.</div></div><div><h3>Methods</h3><div>Using data from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2015), we evaluated 2734 CKM patients (stages 1–4) using RKFD as the primary endpoint. We assessed the associations of NHHR, lnRC, and CHG with renal outcomes using Logistic regression models. Restricted cubic spline and subgroup analyses were used to explore nonlinear relationships and consistency across population strata. Receiver operating characteristic (ROC) curve analysis compared the predictive performance of these indices.</div></div><div><h3>Results</h3><div>Fully adjusted Logistic models showed that a unit increase in NHHR was associated with a 19 % increased RKFD risk (<em>p</em> &lt; 0.001). LnRC and CHG demonstrated more pronounced effects, with risks increasing by 112 % and 125 % per unit, respectively (both <em>p</em> &lt; 0.001). Restricted cubic splines analysis revealed a linear relationship for NHHR and “J-shaped” associations for lnRC and CHG. ROC analysis showed improved discriminative capacity, with receiver operating characteristic curve values of 0.694 (NHHR), 0.734 (lnRC), and 0.695 (CHG).</div></div><div><h3>Conclusions</h3><div>NHHR, lnRC, and CHG are significantly associated with RKFD in CKM patients and are robust predictors of renal function deterioration.</div></div><div><h3>Key learning points</h3><div><ul><li><span>•</span><span><div>What was known: The existing rapid kidney function decline (RKFD) models for patients with cardiovascular-kidney-metabolic (CKM) syndrome lack sensitivity and often overlook the synergistic effect of glucose and lipid metabolism disorders on renal deterioration.</div></span></li><li><span>•</span><span><div>This study adds: The non-HDL-to-HDL cholesterol ratio; Natural Logarithm of Remnant Cholesterol (lnRC); and Cholesterol High-Density Lipoprotein, and Glucose index are strongly associated with RKFD, with lnRC demonstrating superior predictive accuracy over traditional risk factors, with identified thresholds for high-risk stratification.</div></span></li><li><span>•</span><span><div>Potential impact: Integrating these indices into standard clinical practice enhances the early detection of CKM syndrome patients at high risk of RKFD, thus permitting prompt intervention to deceler renal impairment and reduce the likelihood of progression to end-stage kidney disease.</div></span></li></ul></div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112892"},"PeriodicalIF":4.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study","authors":"Tyler R. Bell ,&nbsp;Cynthia Felix ,&nbsp;Nathalie Gider ,&nbsp;George W. Rebok ,&nbsp;Michael Crowe ,&nbsp;Karlene Ball ,&nbsp;Gail Wallace ,&nbsp;Sheila Black ,&nbsp;Kelsey R. Thomas ,&nbsp;Katie M. Wheeler ,&nbsp;Felix J. Kollasserry ,&nbsp;Jeanine M. Parisi ,&nbsp;Caitlin A. Northcutt","doi":"10.1016/j.exger.2025.112891","DOIUrl":"10.1016/j.exger.2025.112891","url":null,"abstract":"<div><div>Chronic pain is highly prevalent in older adults and is associated with elevated risk for disability and dementia. Subjective memory problems (SMPs) - self-rated memory difficulties - are also common and may serve as early indicators of functional decline. This study examined associations between SMPs and cognitive, physical, and psychosocial functioning among older adults with and without chronic pain. Data were drawn from 2365 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study. Multilevel models assessed the impact of baseline and time-varying SMPs on cognitive performance (memory, reasoning, processing speed), physical function (mobility, grip strength, self-rated physical health), and psychosocial outcomes (depressive symptoms, social functioning). Chronic pain, defined as moderate-to-severe pain using the SF-36 Bodily Pain Scale, was tested as a moderator. At baseline, greater SMPs were associated with poorer cognitive performance (βs: −0.52 to −0.23). SMPs and chronic pain were independently linked to worse physical function, lower social functioning, and more depressive symptoms (βs: −0.94 to −0.34; 0.51 to 1.01). Chronic pain uniquely predicted worse mobility and reduced grip strength. Prospectively, SMPs interacted with chronic pain to predict steeper declines in reasoning and physical function. Concurrent increases in SMPs paralleled further declines in most cognitive, physical, and psychosocial domains. Findings suggest that SMPs are stronger predictors of certain outcomes among older adults with chronic pain. These results highlight the importance of jointly considering subjective memory problems and chronic pain to better identify individuals at heightened risk for accelerated functional decline in later life.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112891"},"PeriodicalIF":4.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular global longitudinal strain is associated with physical performance in hospitalized older adults","authors":"Yu Song ,&nbsp;Pan Liu ,&nbsp;Yumeng Chen ,&nbsp;Bixi Li ,&nbsp;Ou Zhao ,&nbsp;Ying Li ,&nbsp;Yun Li ,&nbsp;Lina Ma","doi":"10.1016/j.exger.2025.112890","DOIUrl":"10.1016/j.exger.2025.112890","url":null,"abstract":"<div><h3>Background</h3><div>Low physical performance is associated with adverse clinical outcomes among older adults. Global longitudinal strain (GLS), a sensitive indicator of cardiac dysfunction, has been shown to provide greater predictive value than standard echocardiographic parameters. However, its association with physical performance in older adults remains unclear.</div></div><div><h3>Methods</h3><div>A total of 274 hospitalized patients aged over 60 years with a left ventricular ejection fraction ≥50 % were enrolled. GLS was measured using speckle-tracking echocardiography. Physical performance was evaluated using the Short Physical Performance Battery (SPPB), and participants were categorized into two groups: those with mobility limitation (SPPB ≤9) and those with normal mobility (SPPB &gt;9). Clinical characteristics, echocardiographic parameters, and geriatric assessments were compared between the two groups. Logistic regression, restricted cubic spline, and subgroup interaction analyses were performed to examine the association between GLS and physical performance.</div></div><div><h3>Results</h3><div>Patients with mobility limitations were older and exhibited impaired GLS, worse nutritional status, higher frailty scores, and a greater prevalence of polypharmacy. Logistic regression revealed a graded increase in the odds of mobility limitation with worsening GLS. In the fully adjusted multivariate model, participants in the worst GLS quartile had an odds ratio of 4.21 (95 % confidence interval: 1.57–11.33, <em>P</em> = 0.004) compared to those in the best quartile. Restricted cubic spline analysis showed a significant linear association between GLS and SPPB, gait speed, and chair-rise test time. Subgroup analyses revealed no significant interactions by age, sex, and comorbidities.</div></div><div><h3>Conclusions</h3><div>Impaired GLS was associated with low physical performance among older inpatients with preserved ejection fraction.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112890"},"PeriodicalIF":4.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolytic therapy increases replicative capacity by eliminating senescent endothelial cells","authors":"Hossein Abdeahad ,&nbsp;Denisse G. Moreno ,&nbsp;Samuel I. Bloom ,&nbsp;Hui Huang ,&nbsp;Lisa A. Lesniewski ,&nbsp;Anthony J. Donato","doi":"10.1016/j.exger.2025.112885","DOIUrl":"10.1016/j.exger.2025.112885","url":null,"abstract":"<div><div>Aging is the greatest risk factor for cardiovascular diseases (CVD) and is characterized by inflammation, oxidative stress, and cellular senescence. Cellular senescence is a state of persistent cell cycle arrest triggered by stressors such as DNA damage and telomere attrition. Senescent endothelial cells (ECs) can impair vascular function and promote inflammation, thereby contributing to CVD progression. Senolytics, a class of drugs that selectively eliminate senescent cells, have been shown to remove senescent ECs, but their effects on the replicative capacity and genomic integrity of aged, endothelial cultures remain unclear. In this study, we treated replicative senescent human umbilical vein endothelial cells (HUVECs), used as a model of aged ECs, with Talabostat (10 μM), a novel senolytic, and Navitoclax, 1.0 μM). We hypothesized that senescent cell clearance would be associated with increased proliferative activity and reduced markers of senescence, DNA damage, and telomere dysfunction. Both compounds effectively reduced senescent cell burden, which was accompanied by an increase in cumulative population doublings. Talabostat treatment led to reductions in mean telomere length, DNA damage markers (53BP1), and telomere dysfunction-induced foci (TIFs), suggesting a possible link between increased proliferation and replication-associated telomere attrition. In contrast, Navitoclax treatment increased mitochondrial reactive oxygen species (mtROS) and maintained levels of DNA damage and telomere dysfunction comparable to the vehicle group. Overall, these findings indicate that both Navitoclax and Talabostat can reduce senescent EC burden and promote proliferation in aged EC cultures. Talabostat appears more effective, as it is associated with lower oxidative stress and improved genomic integrity. These results provide insight into how distinct senolytics differentially influence aging-related phenotypes in endothelial cells.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112885"},"PeriodicalIF":4.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and psychometric evaluation of the Polish version of the Chronic Pain Acceptance Questionnaire (CPAQ)","authors":"Joanna Kłosowska ,&nbsp;Magdalena Niedbał ,&nbsp;Aleksandra Budzisz ,&nbsp;Izabela A. Łaska ,&nbsp;Elżbieta A. Bajcar ,&nbsp;Julia Badzińska ,&nbsp;Helena Bieniek ,&nbsp;Justyna Brączyk ,&nbsp;Daryna Rubanets ,&nbsp;Karolina Wiercioch-Kuzianik ,&nbsp;Magdalena Żegleń ,&nbsp;Anna Przeklasa-Muszyńska ,&nbsp;Lance M. McCracken ,&nbsp;Przemysław Bąbel","doi":"10.1016/j.exger.2025.112886","DOIUrl":"10.1016/j.exger.2025.112886","url":null,"abstract":"<div><h3>Background</h3><div>Chronic pain remains a significant health concern, particularly among older adults. Pain acceptance – engaging in valued activities despite pain without attempting to control or avoid it – is thought to buffer against the negative psychosocial impacts of chronic pain.</div></div><div><h3>Objective</h3><div>The present study aimed to adapt to Polish and evaluate the psychometric properties of a widely used measure of pain acceptance, namely the Chronic Pain Acceptance Questionnaire (CPAQ).</div></div><div><h3>Methods</h3><div>Two samples of individuals with chronic pain participated: an online sample (<em>N</em> = 418) and a hospital-recruited sample (<em>N</em> = 148). Confirmatory factor analyses assessed one-factor, two-correlated-factor, and two-orthogonal-factor models for both the original 20-item (CPAQ-20) and the short 8-item (CPAQ-8) versions.</div></div><div><h3>Results</h3><div>In both samples, the results consistently supported a two-factor correlated structure for the Polish CPAQ-8: Activity Engagement (AE) and Pain Willingness (PW). The CPAQ-20 did not show adequate fit. The CPAQ-8 demonstrated acceptable-to-good internal consistency (Cronbach's α = 0.63-0.78 total; 0.75-0.82 subscales) and moderate test–retest reliability (ICC = 0.57). The Minimal Detectable Change for the total score was 9.34 points. In the online sample, CPAQ-8 scores negatively correlated with pain anxiety, pain catastrophizing, anxiety, and depression. Across both samples, total CPAQ-8 and PW scores, but not AE, were negatively associated with pain. Participants reporting activity limitations scored significantly lower on CPAQ-8. Additionally, age was positively correlated with AE scores in both samples.</div></div><div><h3>Conclusions</h3><div>Overall, the Polish CPAQ-8 exhibits good psychometric properties and is suitable for both research and clinical applications. Future studies should examine its longitudinal validity.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112886"},"PeriodicalIF":4.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population” [Exp. Gerontol. 197 (2024) 112585]","authors":"Indranath Chatterjee ,&nbsp;Videsha Bansal","doi":"10.1016/j.exger.2025.112889","DOIUrl":"10.1016/j.exger.2025.112889","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112889"},"PeriodicalIF":4.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and molecular insights into Wiedemann-Rautenstrauch syndrome: A case report and genetic analysis of the c.2707G>A variant in the POLR3A gene","authors":"Karen L. Velásquez-Méndez ,&nbsp;Paula V. Gaete ,&nbsp;Gonzalo Arboleda ,&nbsp;Humberto Arboleda-Granados","doi":"10.1016/j.exger.2025.112887","DOIUrl":"10.1016/j.exger.2025.112887","url":null,"abstract":"<div><div>Wiedemann-Rautenstrauch syndrome (WRS) is a rare neonatal progeroid disorder primarily associated with pathogenic variants in <em>POLR3A</em>. However, the pathogenicity of certain variants remains unclear. Here, we report a WRS case carrying the <em>POLR3A</em> c.2707G &gt; A (p.Gly903Arg) variant and explore its potential role in disease pathogenesis through <em>in silico</em> predictive and structural modeling analyses. Evolutionary conservation analysis, along with functional impact predictions from Provean, SIFT, PolyPhen−2, MutationTaster, MutPred2, Align GVGD, SNAP, and PhD-SNP, consistently classified the variant as deleterious. Splicing predictions using Human Splicing Finder (HSF) and SpliceAI suggested disruption of regulatory motifs and activation of a cryptic splice site. To find potential structural consequences, molecular modeling of the wild-type and mutant RNA polymerase III complex (PDB: <span><span>7DN3</span><svg><path></path></svg></span>) was performed using PyMOL, while DynaMut analysis revealed destabilizing effects, decreased residue flexibility, and steric clashes that could impair complex function. By integrating genetic, computational, and structural approaches, this study not only provides a comprehensive characterization of the <em>POLR3A</em> c.2707G &gt; A (p.Gly903Arg) variant but also contributes to the expanding spectrum of genetic findings in WRS. Our findings highlight the importance of case reports in refining genotype-phenotype correlations and emphasize the need for further functional validation to elucidate the molecular mechanisms underlying WRS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112887"},"PeriodicalIF":4.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between triglyceride-glucose index and glaucoma risk in hypertensive adults: Evidence from a nationally representative cohort","authors":"Kai Kang ,&nbsp;Qianqian Wang ,&nbsp;Yujie Li ,&nbsp;Haozhen Yu ,&nbsp;Zhao Dong","doi":"10.1016/j.exger.2025.112888","DOIUrl":"10.1016/j.exger.2025.112888","url":null,"abstract":"<div><h3>Background</h3><div>The triglyceride-glucose (TyG) index and its obesity-related derivatives have emerged as surrogate markers for metabolic dysfunction. This study aimed to explore their associations with glaucoma in hypertensive adults in the U.S. using NHANES data.</div></div><div><h3>Methods</h3><div>A total of 2458 hypertensive participants aged 40 years or older from NHANES 2005–2008 were included. Glaucoma was defined according to ISGEO-compatible structural and functional criteria. TyG, TyG-BMI, TyG-WC, and TyG-WHtR were calculated using standard formulas. Logistic regression models, restricted cubic splines, ROC curves, and decision curve analysis (DCA) were used to assess associations and predictive performance.</div></div><div><h3>Results</h3><div>All TyG-related indices were positively associated with glaucoma in fully adjusted models. Individuals in the highest TyG quartile had more than twice the odds of glaucoma compared to the lowest quartile (OR = 2.05; 95 % CI: 1.69–2.48, <em>p</em> &lt; 0.0001). TyG-BMI, TyG-WC, and TyG-WHtR also showed increased risks (ORs: 1.57, 95 % CI: 1.29–1.90, <em>p</em> &lt; 0.0001; 1.69, 95 % CI: 1.39–2.04, p &lt; 0.0001; 1.71, 95 % CI: 1.41–2.07, p &lt; 0.0001, respectively). These associations were consistent across age, sex, and race subgroups. A linear relationship was found for TyG, while its derivatives displayed nonlinear trends. TyG showed the best discriminative ability (AUC = 0.831; 95 % CI: 0.804–0.858, <em>p</em> &lt; 0.0001), exceeding BMI, WC, and WHtR. DCA revealed higher net benefit for TyG-based indices, particularly TyG-WHtR and TyG-WC.</div></div><div><h3>Conclusions</h3><div>The TyG index and its derivatives are strong, independent predictors of glaucoma in hypertensive adults, with better diagnostic and clinical value than traditional obesity measures.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112888"},"PeriodicalIF":4.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of repetitions in reserve for prescribing resistance exercise in older adults","authors":"Paola Gómez-Redondo ,&nbsp;Julian Alcazar ,&nbsp;Pedro L. Valenzuela ,&nbsp;Ignacio Ara ,&nbsp;Luis M. Alegre ,&nbsp;Asier Mañas","doi":"10.1016/j.exger.2025.112884","DOIUrl":"10.1016/j.exger.2025.112884","url":null,"abstract":"<div><div>We aimed to assess the validity of predicted repetitions in reserve (RIR) during resistance exercise (RE) in community-dwelling older adults (<em>n</em> = 25; 68 ± 4 yrs.; body mass index [BMI] = 28.1 ± 4.6 kg·m⁻²). Prior to data collection, participants were familiarized with resistance training as well as with the use of RIR and rating of perceived exertion (RPE). Participants completed a one-repetition maximum (1RM) test in the chest press exercise. The repetitions-to-failure test, used to determine actual RIR, was then performed at 65 %-1RM. On a subsequent visit, participants performed 3 sets (65 %-1RM) at the maximum intended velocity (quantified <em>via</em> linear position transducer) until attaining 3 different predicted RIR (2, 4 and 6; in randomized order). After each set, participants reported their RPE. Velocity loss in the last repetition of the predicted RIR-2 (16 % compared to the corresponding repetition in the repetitions-to-failure test; <em>p</em> &lt; 0.001) and RIR-4 (10 %; <em>p</em> = 0.009) was significantly greater, whereas no difference was found for RIR-6 (0 %; <em>p</em> = 0.989). Participants underestimated the number of repetitions for predicted RIR-2 (−2.1 ± 0.3 reps <em>vs.</em> actual RIR-2; <em>p</em> &lt; 0.001) and RIR-4 (−1.6 ± 0.6 reps; <em>p</em> = 0.003), but not for RIR-6 (0.1 ± 0.8 reps; <em>p</em> = 0.823). Predicted RIR-2 was associated with greater velocity loss and number of repetitions compared to predicted RIR-4 and RIR-6 (<em>p</em> &lt; 0.05). RPE values did not significantly differ between predicted RIR-2, RIR-4 and RIR-6 (8.0 ± 0.2, 7.6 ± 0.2, and 7.3 ± 0.3, <em>p</em> &gt; 0.05), suggesting limited sensitivity. Our findings suggest that using predicted RIR may lack precision for accurately prescribing RE in older adults, but might be relatively useful for volume monitoring, especially when interpreted alongside RPE.</div><div>Trial registration: ClinicalTrials.gov ID: NCT05619250</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112884"},"PeriodicalIF":4.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}