Experimental gerontology最新文献

{"title":"Heat stress effects on the immune system of older adults: A systematic literature review","authors":"Rabab Awad ,&nbsp;Assaf Suberry ,&nbsp;Ahmad Abu-Akel ,&nbsp;Liat Ayalon","doi":"10.1016/j.exger.2025.112777","DOIUrl":"10.1016/j.exger.2025.112777","url":null,"abstract":"<div><h3>Objectives</h3><div>We examined the evidence from experimental and cohort studies concerning the associations between heat stress and immune vulnerability in older adults.</div></div><div><h3>Research design and methods</h3><div>A systematic search was performed in 6 academic databases, covering all papers that were published until April 2024. We included studies that explored immune-related outcomes associated with climate change, mainly heat shock, heat exposure, extreme temperature and global warming, among older adults, aged 65 and over. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews were followed to select the studies. Records that retained the exact same search terms from databases were imported into COVIDENCE software and were screened by two independent raters. Major findings were identified and synthesised.</div></div><div><h3>Results</h3><div>Fifteen papers were considered eligible for full-text evaluation, and 4 papers met the inclusion criteria and were included in the analysis. Studies mainly point to age-related dysregulation in heat induced response of subgroups of interleukins and heat shock proteins (hsps).</div></div><div><h3>Discussion and implications</h3><div>Heat stress may directly affect the regulatory function of older adults' immune system that plays a critical rule in the course of infections and inflammatory diseases. However, this review points to a paucity of relevant studies among older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112777"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the appendicular skeletal muscle mass-to-visceral fat area ratio and bone mineral density and osteoporosis: A cross-sectional study","authors":"Jiao Liu ,&nbsp;Fujue Ji ,&nbsp;Haesung Lee ,&nbsp;Jong-Hee Kim","doi":"10.1016/j.exger.2025.112772","DOIUrl":"10.1016/j.exger.2025.112772","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study investigated the association between appendicular skeletal muscle mass-to-visceral fat area ratio (SVR), bone mineral density (BMD), and osteoporosis in U.S. adults using NHANES data.</div></div><div><h3>Methods</h3><div>Data from the 2013–2014 and 2017–2018 NHANES cycles were analyzed. Multivariable regression models assessed associations between SVR, BMD, and osteoporosis, adjusting for demographic, lifestyle, metabolic, and comorbidity variables. Generalized Additive Models with smooth curve fitting and likelihood ratio tests evaluated model fit. Subgroup analyses explored effect modifications.</div></div><div><h3>Results</h3><div>The study included 2325 individuals with a mean age of 50.66 ± 5.55 years. In fully adjusted models, the highest SVR tertile was associated with a 0.05 g/cm² higher BMD (β = 0.05, 95 % CI: 0.03–0.08, <em>P</em> = 0.002) and 57 % lower odds of osteoporosis (OR = 0.43, 95 % CI: 0.24–0.78, <em>P</em> = 0.028) than the lowest tertile. As a continuous variable, SVR remained significantly associated with BMD (β = 0.03, 95 % CI: 0.02–0.04, <em>P</em> = 0.002) and osteoporosis (OR = 0.67, 95 % CI: 0.50–0.91, <em>P</em> = 0.033). Stronger associations were found in individuals with diabetes (β = 0.09, 95 % CI: 0.06–0.12, <em>P</em> &lt; 0.01) and BMI ≥ 30 (β = 0.07, 95 % CI: 0.05–0.09, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Higher SVR was significantly associated with increased BMD and lower odds of osteoporosis, suggesting its potential as a marker for bone health assessment. However, the cross-sectional design limits causal inference. Further longitudinal and mechanistic studies are warranted to confirm these findings and explore clinical applicability.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112772"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of health literacy and self-management on quality of life among older adults with hypertension and diabetes in Northwest China","authors":"Yiliyaer Aihemaiti ,&nbsp;Zhihong Li ,&nbsp;Ying Tong ,&nbsp;Lijun Ma ,&nbsp;Fang Li","doi":"10.1016/j.exger.2025.112776","DOIUrl":"10.1016/j.exger.2025.112776","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the relationship between health literacy, self-management, and quality of life among older adults diagnosed with hypertension and diabetes. Additionally, the influence of these factors on quality of life was assessed to provide a theoretical basis for enhancing the well-being of individuals with chronic conditions.</div></div><div><h3>Methods</h3><div>A cohort of 600 older adults diagnosed with hypertension and diabetes were recruited in Xinjiang, China. Data were collected through a questionnaire survey, and the relationship between health literacy, self-management levels, and quality of life were analysed using a structural equation model (SEM).</div></div><div><h3>Results</h3><div>Of the 600 distributed questionnaires, 556 were completed. Among the older adults with hypertension and diabetes, 17 (3.0 %) demonstrated very adequate health literacy, 188 (33.8 %) had adequate health literacy, 67 (12.1 %) exhibited possible insufficient health literacy, and 284 (51.1 %) were categorized as having insufficient health literacy. The mean self-efficacy score was 6.97 ± 1.03, reflecting low levels of self-management. The average Physical Component Summary score for quality of life was 51.10 ± 12.80, while the average Mental Component Summary score was 70.89 ± 9.43. SEM analysis indicated that quality of life exerted a significant positive effect on health literacy (<em>β</em> = 0.369, <em>P</em> &lt; 0.001) and self-management (<em>β</em> = 0.133, <em>P</em> &lt; 0.01). Furthermore, health literacy was found to significantly positively influence self-management (<em>β</em> = 0.210, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Quality of life in older adults with chronic conditions is significantly influenced by their health literacy and self-management levels. Higher health literacy and improved self-management are associated with enhanced overall quality of life.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112776"},"PeriodicalIF":3.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ‘Internet + dietary diary management’ on serum TP, ALB, PA levels and nutritional risk for elderly patients with esophageal cancer","authors":"Yue Fu,&nbsp;Qingmiao Zhu,&nbsp;Chang Liu,&nbsp;Qi Li,&nbsp;Nuoxiaoxuan Wang,&nbsp;Ning Zhao","doi":"10.1016/j.exger.2025.112780","DOIUrl":"10.1016/j.exger.2025.112780","url":null,"abstract":"<div><h3>Objective</h3><div>This study examines the impact of “Internet + diet diary management” on serum total protein (TP), albumin (ALB), and prealbumin (PA) levels, as well as nutritional risk during the postoperative home care period for elderly esophageal cancer patients.</div></div><div><h3>Methods</h3><div>From May 2022 to May 2023, 74 elderly patients who underwent surgical treatment and were discharged as planned were included. Patients were assigned into a control group and a research group, with 37 in each, using a digital randomization table. Both groups received continuous nursing care, with the research group receiving additional “Internet + diet diary management” during their ongoing care. Serum levels of TP, ALB, and PA, along with other nutritional indicators and scores from the Patient-Generated Subjective Global Assessment (PG-SGA), were compared preoperatively and one month post-discharge.</div></div><div><h3>Results</h3><div>Preoperatively, there was no significant difference in serum indicators and PG-SGA scores between the two groups (<em>P</em> &gt; 0.05). One month postoperatively, the research group showed higher levels of serum ALB, TP, PA, IgA, and IgG, and lower PG-SGA scores than the control group (<em>P</em> &lt; 0.05); no significant differences were found in serum levels of IgM, CA19–9, CA72–4, cyfra21–1, NSE, SCC, and CEA between the groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The application of “Internet + diet diary management” can improve the nutritional status and reduce nutritional risk during the postoperative home care period for elderly patients with esophageal cancer.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112780"},"PeriodicalIF":3.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index and Alzheimer's disease mortality in a prospective cohort","authors":"Ruitong Liao ,&nbsp;Jinzhao Yang ,&nbsp;Xiaoping Huang ,&nbsp;Yue Xu ,&nbsp;Qianqian Ji ,&nbsp;Qi Liu ,&nbsp;Shan Xu ,&nbsp;Peiyi Liu ,&nbsp;Yiqiang Zhan","doi":"10.1016/j.exger.2025.112770","DOIUrl":"10.1016/j.exger.2025.112770","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the relationship between the Dietary Inflammatory Index (DII) and Alzheimer's disease (AD) mortality in US adults.</div></div><div><h3>Methods</h3><div>Data from 45,093 participants in the 1988–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed, with mortality follow-up through December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AD mortality. Restricted cubic spline analysis explored the non-linear association of DII with AD mortality, and stratified analyses identified higher-risk subgroups.</div></div><div><h3>Results</h3><div>Over a median follow-up of 14.3 years, 455 AD-related deaths occurred. Participants in the highest DII quartile (&gt;2.41) had a 1.50-fold increased risk of AD mortality (95 % CI: 1.12–2.01) compared to the lowest quartile (≤−0.44). Pro-inflammatory diets (DII &gt; 0) were associated with a 44 % higher risk of AD mortality (HR: 1.44, 95 % CI: 1.14–1.81). A dose-response relationship was observed, with increased risks across quartiles, and findings were consistent across demographic and clinical subgroups.</div></div><div><h3>Conclusions</h3><div>Higher DII levels were significantly associated with elevated AD mortality risk, highlighting the potential role of pro-inflammatory diets in AD-related outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112770"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis","authors":"Jinhao Zhang ,&nbsp;Wei Ye ,&nbsp;Wang Li ,&nbsp;Fan Zhang ,&nbsp;Zhijian Wu","doi":"10.1016/j.exger.2025.112768","DOIUrl":"10.1016/j.exger.2025.112768","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequately defined. To address these gaps, we conducted a network meta-analysis synthesizing direct and indirect evidence from existing literature to identify the most effective exercise interventions for enhancing cognitive function in older adults.</div></div><div><h3>Methods</h3><div>We conducted a systematic search across databases including PubMed and Web of Science to identify randomized controlled trials (RCTs) evaluating the impact of various exercise interventions on cognitive function in older adults. We assessed the quality of included studies and performed a traditional meta-analysis with Review Manager 5.3. Subsequently, a network meta-analysis was conducted using Stata 17.0 to evaluate the effects of different exercise modalities on cognitive outcomes, specifically memory, inhibitory control, and task-switching abilities.</div></div><div><h3>Results</h3><div>A total of 37 studies encompassing 2585 older adults met the inclusion criteria. The network meta-analysis revealed that resistance training exerted the strongest effect on overall cognitive improvement. Aerobic exercise, multimodal exercise, and physical-mental training followed in effectiveness. Specifically, resistance training significantly enhanced inhibitory control compared to high-intensity interval training (HIIT), aerobic exercise, and other modalities. Physical-mental training emerged as the most effective intervention for improving task-switching ability and demonstrated superior efficacy in enhancing working memory compared to aerobic exercise. Conversely, aerobic exercise showed the strongest effect on memory function, outperforming resistance training, multimodal exercise, and physical-mental training.</div></div><div><h3>Conclusion</h3><div>Resistance training is the most effective exercise modality for enhancing overall cognitive function and inhibitory control in older adults. Physical-mental training offers the greatest benefits for improving working memory and task-switching ability, while aerobic exercise is most beneficial for enhancing memory function. Based on these findings, the recommended exercise protocols are: Resistance Training: 12 weeks, 2–3 times per week, 45 min per session. Aerobic Exercise: 21 weeks, twice per week, 60 min per session. These tailored exercise interventions can inform public health strategies and clinical practices aimed at optimizing cognitive health in the aging population.</div></div><div><h3>Registration</h3><div>The protocol for this review was registered in PROSPERO (CRD42024597545).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112768"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of functional disability with cardiometabolic disease status in a national cohort study","authors":"Ping Ni ,&nbsp;Fang Wang ,&nbsp;Li Liu ,&nbsp;Meiling Ge ,&nbsp;Xiuying Hu","doi":"10.1016/j.exger.2025.112771","DOIUrl":"10.1016/j.exger.2025.112771","url":null,"abstract":"<div><h3>Background</h3><div>Cardiometabolic disease (CMD) status increases the risk of functional disability; however, the reverse relationship remains unclear. This study aimed to examine the impact of different patterns of functional disability on CMD status among Chinese middle-aged and older adults.</div></div><div><h3>Methods</h3><div>We used data from two waves of the China Health and Retirement Longitudinal Study. Functional disability was assessed based on activities of daily living (ADL) and instrumental activities of daily living (IADL), while CMD status was evaluated based on the incidence of diabetes, heart disease, and stroke. Generalized ordinal logistic regression analysis was employed to investigate the impact of functional disability on CMD status.</div></div><div><h3>Results</h3><div>In the longitudinal study, 509 individuals (20.0 %) developed CMD, and 102 individuals (4.0 %) developed cardiometabolic multimorbidity. After adjusting for confounders, Model 1 showed an odds ratio of 1.64 (95 % CI: 1.17, 2.29) for increased CMD status in individuals with ADL and IADL disability compared to those without functional disability. Model 2 and Model 3 produced similar results.</div></div><div><h3>Conclusions</h3><div>Functional disability, particularly ADL and IADL disability, increases the risk of CMD status in Chinese middle-aged and older adults. Measures should be implemented to maintain functional status in middle-aged and older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112771"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigation of learning and memory impairment caused by acute total sleep deprivation through OX1R/OX2R-mediated hippocampal neurogenesis in rats","authors":"Yixin Yu ,&nbsp;Na Shao ,&nbsp;Xiao Zhang ,&nbsp;Wanyu Zhao ,&nbsp;Baokun Zhang ,&nbsp;Jiyou Tang ,&nbsp;Shi Tang","doi":"10.1016/j.exger.2025.112769","DOIUrl":"10.1016/j.exger.2025.112769","url":null,"abstract":"<div><div>Sleep deprivation (SD) impairs learning and memory, which may be correlated with hippocampal neurogenesis. To observe the effects on learning and memory and hippocampal neurogenesis in the hippocampal CA1 area, we first transfected lentivirus to downregulate orexin receptor function in rats. Then, we established a rat model of 72 hourh SD. The Y-maze and Morris water maze tests were deployed to evaluate learning and memory of the rats after SD, 14 days sleep recovery and 28 days sleep recovery. Hippocampal neurogenesis was quantified using BrdU-NeuN immunofluorescence in the dentate gyrus (DG). The results showed that SD impaired learning and memory and reduced the generation of new neurons in DG. The cognition impairments were improved at 14 and 28 days after sleep recovery, but the differentiation and maturation of DG neurons were inhibited during 28 days of sleep recovery. Following the downregulated orexin receptor function after SD, the impairments of learning and memory were alleviated and DG neurogenesis were protected. We hypothesized that the downregulation in orexin receptor function could attenuate the cognition impairment by SD and exert a neuroprotective effect in hippocampus, and this process could be related to the OX1R/OX2R mediated hippocampal neurogenesis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112769"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test","authors":"Daniel Jiménez-Lupión ,&nbsp;Ignacio Chirosa-Ríos ,&nbsp;Rodrigo Lizama-Pérez ,&nbsp;Luis Chirosa-Ríos ,&nbsp;Daniel Jerez-Mayorga","doi":"10.1016/j.exger.2025.112767","DOIUrl":"10.1016/j.exger.2025.112767","url":null,"abstract":"<div><div>Muscle power is a better indicator of musculoskeletal health and functional capacity than muscle strength. The Load-Velocity (L-V) relationship provides a method for assessing muscle function during dynamic multi-joint movements, making it valuable for identifying age-related neuromuscular decline. This study aimed to examine the relationship between variables derived from the L-V relationship (L₀, V₀, and A_line) obtained during the loaded sit-to-stand test and various muscle performance indices, including knee extension peak force (KEPF) and various muscle quality indices (MQI).</div><div>A total of 113 participants (49 middle-aged adults and 64 older adults; age = 61 ± 9.92 years) performed the loaded 5-Sit-To-Stand using Functional Electromechanical Dynamometry. L-V variables were calculated, and their relationships with indicators of muscle performance and quality were analyzed. The impact of age on these variables was also evaluated. The results showed a high positive correlation between A_line and KEPF, MQI_Equation1, MQI_Equation2 and MQI_Equation3 (rs = 0.56–0.59, <em>p</em> ≤0.001–0.01), and between V₀ and KEFP (rs = 0.51, <em>p</em> &lt; 0.001). Older adults exhibited significantly lower L₀ compared to middle-aged adults (76.86 ± 29.74 kg vs. 94.62 ± 35.69 kg, <em>p</em> = 0.007), as well as lower V₀ (0.92 ± 0.28 m·s⁻¹ vs. 1.22 ± 0.19 m·s⁻¹, <em>p</em> &lt; 0.001) and A_line values (35.39 ± 18.95 kg·m·s⁻¹ vs. 57.75 ± 23.84 kg·m·s⁻¹, p &lt; 0.001). These findings suggest that L-V variables are valuable indicators for assessing muscle function deterioration and guiding training interventions, providing a more comprehensive and sensitive assessment of muscle quality and functional status in aging populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112767"},"PeriodicalIF":3.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial investigating the effect of a Baduanjin exercise plus nutrition programme on cancer-related fatigue in elderly lung cancer patients receiving chemotherapy","authors":"Jing Wu ,&nbsp;Chuanfeng Zhang ,&nbsp;Zhao Jing ,&nbsp;Xiushao Wu","doi":"10.1016/j.exger.2025.112763","DOIUrl":"10.1016/j.exger.2025.112763","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to evaluate the benefits of the Baduanjin exercise and nutrition intervention on Cancer-related fatigue (CRF) in elderly lung cancer patients undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>96 elderly patients suffering from lung cancer and undergoing chemotherapy were enlisted and randomly assigned to the control group, the exercise group, and the exercise plus nutrition group. Primary and secondary endpoints were assessed at baseline, week 6, and week 12, including Brief Fatigue Inventory (BFI) scores, Pittsburgh Sleep Quality Index (PSQI) scores, grip strength, and gait speed.</div></div><div><h3>Results</h3><div>Significant beneficial intervention effects were found for CRF, sleep quality, grip strength, and gait speed in the exercise plus nutrition group at 6 and 12 weeks after the treatment. The exercise group improved CRF, grip strength, and gait speed at 12 weeks. No beneficial effects on the outcomes were noticed in the control group.</div></div><div><h3>Conclusions</h3><div>Baduanjin exercise may help alleviate CRF in elderly lung cancer patients undergoing chemotherapy. Moreover, when combined with nutrition intervention, it appears to enhance their sleep quality and physical function more substantially than Baduanjin alone.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112763"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}