Experimental gerontology最新文献

{"title":"The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials","authors":"Liang Ding ,&nbsp;Lijie Lou ,&nbsp;Mingyang Zhang ,&nbsp;Xing Zhang","doi":"10.1016/j.exger.2024.112652","DOIUrl":"10.1016/j.exger.2024.112652","url":null,"abstract":"<div><div>Aerobic and resistance exercises are widely recognized as essential for preserving and enhancing cognitive function. However, the effects of concurrent exercise on cognition in older adults remain unclear. This systematic review sought to evaluate the regular effects of concurrent aerobic and resistance training on global cognition in healthy older adults. A comprehensive search was conducted across PubMed, Web of Science, EMBASE, Google Scholar, Cochrane Library, and CNKI up to July 2024. Randomized controlled trials involving healthy older adults aged ≥65 years that assessed the cognitive effects of concurrent exercise were included. The methodological quality of the included studies was evaluated using the PEDro scale. Meta-analyses were performed using a random-effects model, and heterogeneity was quantified with the I² statistic. The initial search identified 13,533 records, ultimately including 12 studies in the meta-analysis, which involved 2557 participants. The meta-analysis revealed non-significant effects of concurrent exercise on global cognition (SMD = 0.12, 95 % CI: −0.08 to 0.33, <em>p</em> = 0.200). The subgroup analysis indicated that concurrent exercise cannot enhance global cognition compared to active controls (SMD = −0.03, 95 % CI: −0.23 to 0.18, <em>p</em> = 0.80), but it does show significant improvement compared to passive controls (SMD = 0.35, 95 % CI: 0.14 to 0.56, <em>p</em> &lt; 0.001). Moderate heterogeneity was observed (I² = 49.9 %), and sensitivity analyses confirmed the stability of the results. No significant publication bias was identified. While concurrent exercise was effective in improving global cognition in healthy older adults, the improvements were not superior to active control conditions. Future research should investigate optimal training combinations and sequences to maximize cognitive benefits.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112652"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes","authors":"Kun Zhang ,&nbsp;Bo Hou ,&nbsp;Tao Yan ,&nbsp;Ruru Qiao ,&nbsp;Peng Qu ,&nbsp;Xinbo Xu ,&nbsp;Hanbing Zhang","doi":"10.1016/j.exger.2025.112676","DOIUrl":"10.1016/j.exger.2025.112676","url":null,"abstract":"<div><h3>Background</h3><div>Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. Therefore, we performed a systematic genome-wide MR of drug-eligible individuals to explore potential therapeutic targets for ARHL.</div></div><div><h3>Methods</h3><div>We obtained data on the expression quantitative trait locis (eQTLs) of druggable genes, which were then subjected to two-sample MR analyses and co-localisation analyses with data from the ARHL genome-wide association study to identify genes highly associated with ARHL. Additionally, we conducted phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking to help develop more effective and targeted therapeutic treatments.</div></div><div><h3>Results</h3><div>Overall, the MR analysis of eQTL data showed that 14 drug targets were significantly associated with ARHL. GO analysis of 14 potential targets revealed their primary involvement in biological processes such as the endoplasmic reticulum unfolded protein response, ER-nucleus signaling pathway, and fibroblast apoptotic process. Additionally, important cellular components include the Bcl-2 family of proteins and the endoplasmic reticulum lumen. After filtering using methods such as phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking, six potentially druggable genes (BAK1, AMFR, LAMP3, STK17B, ACP5, and CD9) and six drugs (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, and naftidrofuryl) that may affect ARHL outcomes were finally identified.</div></div><div><h3>Conclusions</h3><div>Our findings identified 14 potential drug targets for ARHL. These findings offer promising leads for more effective treatments for ARHL and help determine the priority of drug development, potentially reducing costs.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112676"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice","authors":"Tianchan Peng ,&nbsp;Jian Xiang ,&nbsp;Yun Tian ,&nbsp;Xiaogen Tang ,&nbsp;Lina Wang ,&nbsp;Lijuan Gao ,&nbsp;Oscar Junhong Luo ,&nbsp;Li’an Huang ,&nbsp;Guobing Chen","doi":"10.1016/j.exger.2025.112686","DOIUrl":"10.1016/j.exger.2025.112686","url":null,"abstract":"<div><h3>Background</h3><div>Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking.</div></div><div><h3>Objective</h3><div>To investigate the geroprotective effects of <em>Lycium barbarum</em> glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model.</div></div><div><h3>Methods</h3><div>Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks to induce aging, while LbGp was orally administered (100 mg/kg/day) throughout the study. The geroprotective effects of LbGp were assessed by behavioral tests, cardiac echocardiography, pathohistological and transcriptomic analyses. Transmission electron microscopy was used to observe the ultrastructure of mitochondria. Mitochondrial stress assays and JC-1 fluorescent probe were conducted to evaluate mitochondrial function. Flow cytometer and western blot were performed to assess mitophagy flux.</div></div><div><h3>Results</h3><div>LbGp treatment improved the aging phenotypes of D-galactose-induced mice, with a pronounced enhancement in cardiac function compared to neurocognitive and skeletal muscle functions. Transcriptome analysis indicated that LbGp ameliorated energy metabolism in the heart. Mitochondrial assays revealed LbGp improved mitochondrial function and preserved structural integrity of the mitochondrial inner membrane. LbGp attenuated mitochondrial fission and restored impaired PINK1/Parkin-mediated mitophagy pathway caused by D-galactose in cardiomyocytes.</div></div><div><h3>Conclusion</h3><div>LbGp can ameliorate aging phenotypes and enhance cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice. These findings underscore its potential as a therapeutic agent for aging and aging-related cardiovascular diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112686"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis","authors":"Yijian Deng ,&nbsp;Liying Zeng ,&nbsp;Yigui Lai ,&nbsp;Shuai Ji ,&nbsp;Baizhao Peng ,&nbsp;Hanqi Lu ,&nbsp;Ming Wang ,&nbsp;Hiu Yee Kwan ,&nbsp;Qi Wang ,&nbsp;Xiaoshan Zhao","doi":"10.1016/j.exger.2025.112677","DOIUrl":"10.1016/j.exger.2025.112677","url":null,"abstract":"<div><h3>Background</h3><div>Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain.</div></div><div><h3>Methods</h3><div>The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (<em>n</em> = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis.</div></div><div><h3>Results</h3><div>The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, <em>P</em> = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, <em>P</em> = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, <em>P</em> = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, <em>P</em> = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs.</div></div><div><h3>Conclusion</h3><div>The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112677"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study","authors":"Jeong Min Yang ,&nbsp;Jieun Hwang","doi":"10.1016/j.exger.2025.112681","DOIUrl":"10.1016/j.exger.2025.112681","url":null,"abstract":"<div><h3>Purpose</h3><div>Recently, the World Health Organization has emphasized the importance of a healthy lifestyle in reducing severe illnesses and premature mortality. To evaluate this, the Healthy Lifestyle Score (HLS), which focuses on health protecting behaviors (e.g., smoking, alcohol consumption, physical activity, body mass index), is widely used. However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. Accordingly, this study aims to track HLS trajectories (HLST) and examine their association with mortality among middle-aged and older Koreans.</div></div><div><h3>Methods</h3><div>After excluding missing values, data from 6249 participants were analyzed using the group-based trajectory model (GBTM) to classify HLST, based on the first to fourth waves of the Korean Longitudinal Study of Aging (KLoSA). The chi-square test and Cox proportional hazards model were employed to examine the association between HLST and all-cause mortality over a 10-year follow-up period (December 31, 2012, to December 31, 2022; 3650 days).</div></div><div><h3>Results</h3><div>Three HLST groups were identified in the GBTM analysis. These were the Poor HLST (17.8 %), Average HLST (42.9 %), and Good HLST (39.4 %) groups. Compared to the good HLST, the poor HLST had higher mortality at 1 year (hazard ratio [HR]: 1.98, p: 0.029), 3 years (HR: 1.78, p: 0.001), 5 years (HR: 1.52, p: 0.002), 7 years (HR: 1.39, p: 0.002), and 10 years (HR: 1.40, p: 0.000). Furthermore, stratified analysis by sex, age, marital status and residential region showed that male, ≥65 years, single and urban area groups had a strong association between HLST and all-cause mortality.</div></div><div><h3>Conclusion</h3><div>The findings of this study underscore the necessity of policies and institutional measures grounded in community networks to mitigate the risk of all-cause mortality among vulnerable groups with persistently poor HLST.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112681"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics","authors":"Guilherme da Silva Rodrigues ,&nbsp;Andressa Crystine da Silva Sobrinho ,&nbsp;Gabriel Peinado Costa ,&nbsp;Leonardo Santos Lopes da Silva ,&nbsp;João Gabriel Ribeiro de Lima ,&nbsp;Leonardo da Silva Gonçalves ,&nbsp;Larissa Chacon Finzeto ,&nbsp;Carlos Roberto Bueno Júnior","doi":"10.1016/j.exger.2024.112669","DOIUrl":"10.1016/j.exger.2024.112669","url":null,"abstract":"<div><div>This study employed multivariate analysis to investigate the effects of a 14-week multicomponent training program on sedentary adults and older populations, focusing on improvements in physical fitness, health markers, and anthropometric measures. The data included 376 participants aged 30 to 84 years who had been inactive for at least 3 months. Results showed that participants aged 71 and above had lower systolic blood pressure, height, body mass, elbow flexion and extension, sitting and standing up from a chair, agility, 6-Minute Walk Test (6MWT), and handgrip strength values compared to younger age groups (p &lt; 0.05). Initially, the 6MWT was inversely correlated with anthropometric measures and positively correlated with strength tests, but after the intervention, it remained correlated only with handgrip strength and agility. Interestingly, the elbow flexion and extension strongly correlated with other fitness measures pre-intervention, but these relationships weakened afterward. Agility became a key intermediary variable in the analysis. Despite improvements, anthropometric variables like body mass and waist circumference continued to have a strong relationship with fitness outcomes. Significant gains were observed in the 6MWT and elbow flexion and extension (p &lt; 0.05), indicating improvements in aerobic fitness and strength. Multivariate analysis showed that hip circumference, chair stand test, handgrip strength, and agility significantly influenced 6MWT performance. Using multivariate analysis, we were able to highlight the importance of incorporating regular exercise into daily life to promote active and healthy aging. Furthermore, agility emerged as the most significant intermediate variable after the intervention. This insight suggests that improvements in agility may be crucial for physical fitness and overall health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112669"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foresight older adults' quality of life in the aging crisis in Iran: A systematic review and meta-analysis","authors":"Raheleh Alimoradzadeh ,&nbsp;Katayoun Jahangiri ,&nbsp;Roya Alimoradzadeh","doi":"10.1016/j.exger.2024.112671","DOIUrl":"10.1016/j.exger.2024.112671","url":null,"abstract":"<div><h3>Introduction</h3><div>To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted.</div></div><div><h3>Methods</h3><div>All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023.</div></div><div><h3>Results</h3><div>Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7.</div></div><div><h3>Conclusion</h3><div>The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112671"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents","authors":"Erivaldo Machado Araújo ,&nbsp;Hélio José Coelho-Júnior ,&nbsp;Caio Victor Sousa ,&nbsp;Thiago dos Santos Rosa ,&nbsp;Ivo Vieira Sousa Neto ,&nbsp;Emanuele Marzetti ,&nbsp;Octávio Luiz Franco ,&nbsp;Samuel da Silva Aguiar","doi":"10.1016/j.exger.2024.112662","DOIUrl":"10.1016/j.exger.2024.112662","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.</div></div><div><h3>Methods</h3><div>The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14–15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2–13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation.</div></div><div><h3>Results</h3><div>Dual-task RT significantly enhanced balance (<em>p</em> = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (<em>p</em> = 0.008) and post-detraining (<em>p</em> = 0.015) relative to baseline. Cognitive ability showed significant improvements (<em>p</em> &lt; 0.05). The CAT/TBARS ratio increased significantly post-training (<em>p</em> &lt; 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (<em>p</em> &lt; 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112662"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia: A cross-sectional study","authors":"Xiudeng Yang ,&nbsp;Zheng Zhong","doi":"10.1016/j.exger.2025.112680","DOIUrl":"10.1016/j.exger.2025.112680","url":null,"abstract":"<div><h3>Background</h3><div>The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a newly developed lipid parameter that's used to evaluate cardiovascular disease risk. However, its association with sarcopenia risk has not been explored before.</div></div><div><h3>Methods</h3><div>Data on NHHR and sarcopenia were based on the secondary analysis of the years 2011–2018 of National Health and Nutrition Examination Survey (NHANES) dataset. NHHR was nature log-transformed (LnNHHR) to achieve a normal distribution. A multivariate logistic regression and a restricted cubic spline (RCS) model adjusted for associated factors were utilized to evaluate the correlation between NHHR and sarcopenia. Subgroup and sensitivity analyses were conducted to verify the robustness of the findings.</div></div><div><h3>Results</h3><div>The study cohort comprised 7069 participants, of whom 6497 (91.91 %) were sarcopenia-free, and 572 (8.09 %) exhibited sarcopenia. A significant increase in NHHR was observed in the sarcopenia group compared to the non-sarcopenic group (<em>P</em> &lt; 0.001). Multivariate logistic regression analysis revealed that sarcopenia was independently linked to NHHR [odds ratio (OR): 1.394, <em>P</em> = 0.007]. A linear relationship was identified between NHHR and sarcopenia risk (<em>P</em>_non-linear = 0.108). Interaction analysis indicated that the relationship between NHHR and sarcopenia risk was not significantly modified by gender, sex, poverty income ratio, education, smoking status, or race.</div></div><div><h3>Conclusion</h3><div>NHHR was significantly associated with an elevated risk of sarcopenia among U.S. adults. Further research is warranted to elucidate the underlying physiological mechanisms through which NHHR influences sarcopenia development.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112680"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome","authors":"Valerie Lohner ,&nbsp;Laura Perna ,&nbsp;Ben Schöttker ,&nbsp;Robert Perneczky ,&nbsp;Hermann Brenner ,&nbsp;Ute Mons","doi":"10.1016/j.exger.2025.112684","DOIUrl":"10.1016/j.exger.2025.112684","url":null,"abstract":"<div><h3>Background</h3><div>In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).</div></div><div><h3>Methods</h3><div>We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (<em>n</em> = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (<em>n</em> = 377), and amyloid β (Aβ₄₀, Aβ₄₂, Aβ₄₂/Aβ₄₀) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (<em>ApoE</em>) ε4 genotype.</div></div><div><h3>Results</h3><div>Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). The Aβ₄₀/Aβ₄₂-ratio was linked to incident stroke (0.72 (0.52–1.00)). Associations of GFAP with all-cause mortality and incident stroke were depending on <em>ApoE</em> ε4 genotype. The other biomarkers were not significantly associated with the studied outcomes.</div></div><div><h3>Conclusions</h3><div>In persons with CSS, NfL and the Aβ₄₀/Aβ₄₂-ratio were related to mortality and incident stroke, respectively, whereas associations of GFAP with adverse outcomes varied by <em>ApoE</em> genotype. These biomarkers might play a role in linking aging, cardiovascular and neurodegenerative diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112684"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}