担心跌倒的老年人的压力系统和炎症之间的关系——来自FEARFALL研究的发现。

IF 4.3

Experimental gerontology Pub Date : 2025-09-17 DOI:10.1016/j.exger.2025.112899

Anja Müller , Robert Kob , Cornel Christian Sieber , Ellen Freiberger , Nicolas Rohleder , Sabine Britting

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引用次数: 0

摘要

老年人担心跌倒（CaF）与活动减少和负面健康结果有关。本研究的目的是研究社区居住老年人的CaF、应激系统活性和低度炎症之间的关系。在随机对照的FEARFALL研究中，N = 纳入了160名老年人（≥70 岁）（平均年龄：79.52岁，73.8 %为女性）；分析了102例的数据。采用跌落效能国际量表（FESI）、FES-I回避行为量表（FES-IAB）和更新的跌落量表感知控制量表（UP-CoF）评估CaF。分析唾液样本以确定应激系统活性（皮质醇，α -淀粉酶）。检测血中炎症标志物（c反应蛋白[CRP]、白细胞介素-6 [IL-6]）。较高的UP-CoF评分与较高的个体皮质醇值显著相关（β = 0.01,95 %-CI [0.00; 0.01], p = ）。047)，且与皮质醇日下降幅度较大有轻微关联（p = .059）。CaF与α -淀粉酶或其参数（AAR、slope、AUCg）之间无显著关联。IL-6与年龄显著相关（β = 0.01,95 %-CI [0.00; 0.01], p = ）。019)和BMI(β = 0.27,95 % ci [0.00, 0.02], p = 。004)， CRP与BMI也有显著相关性（β = 0.01,95 %-CI [0.00; 0.02], p = .004）。CaF与炎症标志物之间无显著相关性。对跌倒的感知控制与生理皮质醇动力学有关，并可能在调节老年人的应激系统活动中发挥作用。这些发现表明，心理因素，如感知控制，可能会影响老年人的压力调节。

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Relationship between stress systems and inflammation in older adults concerned about falling – Findings from the FEARFALL study

Concerns about falling (CaF) in older adults are associated with decreased activity and negative health outcomes. The aim of this study was to examine associations between CaF, stress system activity, and low-grade inflammation in community-dwelling older adults.

In the randomized-controlled FEARFALL study, N = 160 older adults (≥70 years) were enrolled (mean age: 79.5; 73.8 % women); data from 102 were analyzed. The Falls Efficacy Scale-International (FES-I), the FES-I Avoidance Behavior (FES-IAB) and Updated Perceived Control over Falling Scale (UP-CoF) were used to assess CaF. Saliva samples were analyzed to determine stress system activity (cortisol, alpha-amylase). Inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6]) were determined in blood.

A higher UP-CoF score was significantly associated with higher individual cortisol values (β = 0.01, 95 %-CI [0.00, 0.01], p = .047) and was marginally associated with a steeper diurnal cortisol decline (p = .059). No significant associations were found between CaF and alpha-amylase or its parameters (AAR, slope, AUCg). IL-6 was significantly associated with age (β = 0.01, 95 %-CI [0.00, 0.01], p = .019) and BMI (β = 0.27, 95 %-CI [0.00, 0.02], p = .004), while CRP also showed a significant association with BMI (β = 0.01, 95 %-CI [0.00, 0.02], p = .004). There were no significant associations between CaF and inflammatory markers.

Perceived control over falls is associated with physiological cortisol dynamics and may play a role in regulating the stress system activity in older adults. These findings show that psychological factors, such as perceived control, may influence stress regulation in older adults.

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来源期刊

Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

66 days