Experimental gerontology最新文献

{"title":"Associations of non-exercise estimated cardiorespiratory fitness with mortality risk in individuals with diabetic kidney diseases: Analysis of 1999-2018 NHANES data.","authors":"Xiaoxu Ge, Juan Du, Jiajia Wang, Liuqing Xi, Wenfang Peng, Shan Huang, Ying Xie","doi":"10.1016/j.exger.2025.112856","DOIUrl":"10.1016/j.exger.2025.112856","url":null,"abstract":"<p><strong>Objective: </strong>Although non-exercise estimated cardiorespiratory fitness (eCRF) algorithms correlate well with measured CRF, their prognostic value in high-risk populations remains unclear. We investigated the associations between eCRF and mortality risk in adults with diabetic kidney disease (DKD), a vulnerable population with elevated mortality risk.</p><p><strong>Methods: </strong>Data from adults with DKD were derived from the 1999-2018 National Health and Nutrition Examination Survey. The primary exposure was eCRF, which was calculated from validated algorithm incorporating age, sex, body mass index, waist circumference, resting heart rate, physical activity, and smoking status. The primary outcomes were all-cause and cardiovascular disease (CVD) mortality. Hazard ratios (HRs) and 95 % confidence intervals (CIs) were calculated from Cox proportional hazards models for the associations between eCRF and mortality risk.</p><p><strong>Results: </strong>Among 2045 participants (mean age 61.65 years, 52.10 % men) included, 804 (35.84 %) deaths occurred during a median follow-up of 84 months, of which 296 were from CVD causes. Compared with the highest eCRF quartile, the HRs (95 % CIs) of the lowest quartile were 1.75 (1.27-2.40) for all-cause mortality and 2.29 (1.32-3.99) for CVD mortality. Restricted cubic spline curves demonstrated inversely linear relationships between eCRF and all-cause and CVD mortality. Associations between eCRF and all-cause mortality were stronger in female participants, those with overweight or obesity, and those without prior CVD.</p><p><strong>Conclusions: </strong>Lower eCRF was independently associated with elevated risks of all-cause and CVD mortality in individuals with DKD, supporting the utility of eCRF as a practical prognostic tool in clinical management of DKD.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112856"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular senescence in skeletal diseases: A bibliometric analysis from 2007 to 2024.","authors":"Xuanrui Zhang, Biao Yang, Xunpei Xu, Zhanrong Zhang, Zhengbo Tao, Weijin Zhang, Zheng Zhang, Xuhui Zhou","doi":"10.1016/j.exger.2025.112857","DOIUrl":"10.1016/j.exger.2025.112857","url":null,"abstract":"<p><strong>Background: </strong>Cellular senescence is a state of permanent cell cycle arrest. Numerous studies have highlighted the significant role of cellular senescence in age-related skeletal diseases, including intervertebral disc degeneration (IDD), osteoporosis, and osteoarthritis (OA). This article aims to review the current research landscape and identify emerging trends.</p><p><strong>Methods: </strong>Literature concerning cellular senescence and skeletal disease was obtained from the Web of Science Core Collection database, covering publications from 2007 to 2024. The Bibliometrix R package, VOSviewer, and CiteSpace were employed to perform the bibliometric analysis.</p><p><strong>Results: </strong>A total of 2653 publications were analyzed, revealing a rapid growth trend. China emerged as the dominant contributor, with the highest publication volume (n = 1148), while the United States led in citation impact (total citations = 50,420). Key journals, such as Osteoarthritis and Cartilage and Aging Cell, served as primary platforms for high-impact studies. The most influential author was James L. Kirkland, followed by Richard F. Loeser. Keyword clustering identified cellular senescence in intervertebral disc degeneration, osteoporosis, and osteoarthritis as core research domains, while current frontiers focus on the senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, extracellular vesicles, and immune infiltration.</p><p><strong>Conclusion: </strong>Research in this field has garnered substantial attention in recent years. This bibliometric analysis not only underscores the correlation between cellular senescence and skeletal diseases, but also highlights that targeting cellular senescence and the SASP may offer potential therapeutic strategies. These findings can inform future research directions and the development of targeted interventions for age-related skeletal conditions.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112857"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes in nutritional status and sleep disturbance in Parkinson's disease.","authors":"Bingchuan Xie, Junqiang Bao, Lizhuang Zhang, Zhenguo Wu, Hongmin Zhao","doi":"10.1016/j.exger.2025.112855","DOIUrl":"10.1016/j.exger.2025.112855","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the relationship between dynamic changes in nutritional status and sleep disturbance in patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>This study included 209 PD patients with regular follow-ups from January 2021 to January 2023. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Data on nutritional indicators, including albumin, hemoglobin, total protein, cholesterol, triglyceride, LDL cholesterol, prealbumin, transferrin, NEFA, and retinol-binding protein (RBP), were collected at both admission and discharge. Patients were categorized into groups based on changes in albumin levels, and the relationship between nutritional status and sleep disturbance was analyzed.</p><p><strong>Results: </strong>The study found that 27.75 % of patients experienced malnutrition, while 48.33 % had sleep disturbance. Before treatment, BMI, MDS-UPDRS, albumin, hemoglobin, total protein, cholesterol, triglyceride, transferrin, NEFA, and RBP were positively associated with sleep disturbance (r = 5.012, 6.821, 3.291, 0.782, 0.674, 0.813, 0.938, 0.531, 0.763, 0.362, P < 0.001); age, LDL cholesterol, and prealbumin were negatively correlated (r = -2.182, -2.187, -9.761, P < 0.001). Multivariate logistic regression analysis identified prealbumin as a significant risk factor for sleep disturbance (OR: 1.384, 95 % CI: 1.062-1.883, P < 0.05).</p><p><strong>Conclusions: </strong>The study concluded that nutritional status, particularly levels of albumin and prealbumin, is closely related to the occurrence of sleep disturbance in PD patients.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112855"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do older adults with and without a history of falls show different gait patterns in response to individualized treadmill perturbations?","authors":"Michel Hackbarth, Tania Zieschang, Sandra Lau, Jessica Koschate-Storm","doi":"10.1016/j.exger.2025.112853","DOIUrl":"10.1016/j.exger.2025.112853","url":null,"abstract":"<p><strong>Background: </strong>Dynamic reactive balance is key to avoid falls during walking and can be challenged with treadmill-based gait perturbations. The use of mechanical gait perturbations to measure reactive dynamic balance performance, is discussed to identify individuals at risk of falling. Gait speed and perturbation intensity, are often standardized in study populations. In heterogeneous study populations, this entails the risk of either overburdening the participants or failing to adequately challenge them.</p><p><strong>Research question: </strong>Are gait parameters and compensatory steps, after mechanical treadmill-based perturbations using perturbation intensities at the individual single step threshold and preferred walking speed, different between younger and older adults with or without a history of falling?</p><p><strong>Methods: </strong>In this study, 86 younger and older adults with and without a history of falls completed two treadmill-walking trials with mediolateral and anteposterior perturbations. Step length and step width were analyzed before and after perturbations using ANOVA with repeated measures.</p><p><strong>Results: </strong>The adjustments of both parameters to individualized mediolateral perturbations differed between younger and older participants, while between older adults with and without a history of falls, only small differences in step width (p < 0.001, η_p² = 0.141) were observed.</p><p><strong>Significance: </strong>Individually tailored treadmill-perturbations can be safely applied in older adults. Compensatory steps as a reaction to perturbations differ between younger and older adults. However, at the individual limit of balance control, differences between older adults with and without a history of falls are small.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112853"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-conventional lipid parameters predict the risk of rapid kidney function decline in patients with cardiovascular-kidney-metabolic syndrome: The first cohort study evidence from CHARLS.","authors":"Mengying Dong, Xueqi Chen, Jiangen Liu, Chunjian Li","doi":"10.1016/j.exger.2025.112892","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112892","url":null,"abstract":"<p><strong>Background: </strong>This study evaluates the predictive value of three novel lipid-derived biomarkers: non-HDL-to-HDL cholesterol ratio (NHHR); natural logarithm of remnant cholesterol (lnRC); and cholesterol, high-density lipoprotein, and glucose index (CHG) for rapid kidney function decline (RKFD) in patients with cardiovascular-kidney-metabolic (CKM) syndrome.</p><p><strong>Methods: </strong>Using data from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015), we evaluated 2734 CKM patients (stages 1-4) using RKFD as the primary endpoint. We assessed the associations of NHHR, lnRC, and CHG with renal outcomes using Logistic regression models. Restricted cubic spline and subgroup analyses were used to explore nonlinear relationships and consistency across population strata. Receiver operating characteristic (ROC) curve analysis compared the predictive performance of these indices.</p><p><strong>Results: </strong>Fully adjusted Logistic models showed that a unit increase in NHHR was associated with a 19 % increased RKFD risk (p < 0.001). LnRC and CHG demonstrated more pronounced effects, with risks increasing by 112 % and 125 % per unit, respectively (both p < 0.001). Restricted cubic splines analysis revealed a linear relationship for NHHR and \"J-shaped\" associations for lnRC and CHG. ROC analysis showed improved discriminative capacity, with receiver operating characteristic curve values of 0.694 (NHHR), 0.734 (lnRC), and 0.695 (CHG).</p><p><strong>Conclusions: </strong>NHHR, lnRC, and CHG are significantly associated with RKFD in CKM patients and are robust predictors of renal function deterioration.</p><p><strong>Key learning points: </strong></p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112892"},"PeriodicalIF":4.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain and subjective memory problems are dynamic risk factors for functional decline: An ACTIVE longitudinal study.","authors":"Tyler R Bell, Cynthia Felix, Nathalie Gider, George W Rebok, Michael Crowe, Karlene Ball, Gail Wallace, Sheila Black, Kelsey R Thomas, Katie M Wheeler, Felix J Kollasserry, Jeanine M Parisi, Caitlin A Northcutt","doi":"10.1016/j.exger.2025.112891","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112891","url":null,"abstract":"<p><p>Chronic pain is highly prevalent in older adults and is associated with elevated risk for disability and dementia. Subjective memory problems (SMPs) - self-rated memory difficulties - are also common and may serve as early indicators of functional decline. This study examined associations between SMPs and cognitive, physical, and psychosocial functioning among older adults with and without chronic pain. Data were drawn from 2365 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study. Multilevel models assessed the impact of baseline and time-varying SMPs on cognitive performance (memory, reasoning, processing speed), physical function (mobility, grip strength, self-rated physical health), and psychosocial outcomes (depressive symptoms, social functioning). Chronic pain, defined as moderate-to-severe pain using the SF-36 Bodily Pain Scale, was tested as a moderator. At baseline, greater SMPs were associated with poorer cognitive performance (βs: -0.52 to -0.23). SMPs and chronic pain were independently linked to worse physical function, lower social functioning, and more depressive symptoms (βs: -0.94 to -0.34; 0.51 to 1.01). Chronic pain uniquely predicted worse mobility and reduced grip strength. Prospectively, SMPs interacted with chronic pain to predict steeper declines in reasoning and physical function. Concurrent increases in SMPs paralleled further declines in most cognitive, physical, and psychosocial domains. Findings suggest that SMPs are stronger predictors of certain outcomes among older adults with chronic pain. These results highlight the importance of jointly considering subjective memory problems and chronic pain to better identify individuals at heightened risk for accelerated functional decline in later life.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112891"},"PeriodicalIF":4.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular global longitudinal strain is associated with physical performance in hospitalized older adults","authors":"Yu Song ,&nbsp;Pan Liu ,&nbsp;Yumeng Chen ,&nbsp;Bixi Li ,&nbsp;Ou Zhao ,&nbsp;Ying Li ,&nbsp;Yun Li ,&nbsp;Lina Ma","doi":"10.1016/j.exger.2025.112890","DOIUrl":"10.1016/j.exger.2025.112890","url":null,"abstract":"<div><h3>Background</h3><div>Low physical performance is associated with adverse clinical outcomes among older adults. Global longitudinal strain (GLS), a sensitive indicator of cardiac dysfunction, has been shown to provide greater predictive value than standard echocardiographic parameters. However, its association with physical performance in older adults remains unclear.</div></div><div><h3>Methods</h3><div>A total of 274 hospitalized patients aged over 60 years with a left ventricular ejection fraction ≥50 % were enrolled. GLS was measured using speckle-tracking echocardiography. Physical performance was evaluated using the Short Physical Performance Battery (SPPB), and participants were categorized into two groups: those with mobility limitation (SPPB ≤9) and those with normal mobility (SPPB &gt;9). Clinical characteristics, echocardiographic parameters, and geriatric assessments were compared between the two groups. Logistic regression, restricted cubic spline, and subgroup interaction analyses were performed to examine the association between GLS and physical performance.</div></div><div><h3>Results</h3><div>Patients with mobility limitations were older and exhibited impaired GLS, worse nutritional status, higher frailty scores, and a greater prevalence of polypharmacy. Logistic regression revealed a graded increase in the odds of mobility limitation with worsening GLS. In the fully adjusted multivariate model, participants in the worst GLS quartile had an odds ratio of 4.21 (95 % confidence interval: 1.57–11.33, <em>P</em> = 0.004) compared to those in the best quartile. Restricted cubic spline analysis showed a significant linear association between GLS and SPPB, gait speed, and chair-rise test time. Subgroup analyses revealed no significant interactions by age, sex, and comorbidities.</div></div><div><h3>Conclusions</h3><div>Impaired GLS was associated with low physical performance among older inpatients with preserved ejection fraction.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112890"},"PeriodicalIF":4.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolytic therapy increases replicative capacity by eliminating senescent endothelial cells.","authors":"Hossein Abdeahad, Denisse G Moreno, Samuel I Bloom, Hui Huang, Lisa A Lesniewski, Anthony J Donato","doi":"10.1016/j.exger.2025.112885","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112885","url":null,"abstract":"<p><p>Aging is the greatest risk factor for cardiovascular diseases (CVD) and is characterized by inflammation, oxidative stress, and cellular senescence. Cellular senescence is a state of persistent cell cycle arrest triggered by stressors such as DNA damage and telomere attrition. Senescent endothelial cells (ECs) can impair vascular function and promote inflammation, thereby contributing to CVD progression. Senolytics, a class of drugs that selectively eliminate senescent cells, have been shown to remove senescent ECs, but their effects on the replicative capacity and genomic integrity of aged, endothelial cultures remain unclear. In this study, we treated replicative senescent human umbilical vein endothelial cells (HUVECs), used as a model of aged ECs, with Talabostat (10 μM), a novel senolytic, and Navitoclax, 1.0 μM). We hypothesized that senescent cell clearance would be associated with increased proliferative activity and reduced markers of senescence, DNA damage, and telomere dysfunction. Both compounds effectively reduced senescent cell burden, which was accompanied by an increase in cumulative population doublings. Talabostat treatment led to reductions in mean telomere length, DNA damage markers (53BP1), and telomere dysfunction-induced foci (TIFs), suggesting a possible link between increased proliferation and replication-associated telomere attrition. In contrast, Navitoclax treatment increased mitochondrial reactive oxygen species (mtROS) and maintained levels of DNA damage and telomere dysfunction comparable to the vehicle group. Overall, these findings indicate that both Navitoclax and Talabostat can reduce senescent EC burden and promote proliferation in aged EC cultures. Talabostat appears more effective, as it is associated with lower oxidative stress and improved genomic integrity. These results provide insight into how distinct senolytics differentially influence aging-related phenotypes in endothelial cells.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112885"},"PeriodicalIF":4.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and psychometric evaluation of the Polish version of the Chronic Pain Acceptance Questionnaire (CPAQ)","authors":"Joanna Kłosowska ,&nbsp;Magdalena Niedbał ,&nbsp;Aleksandra Budzisz ,&nbsp;Izabela A. Łaska ,&nbsp;Elżbieta A. Bajcar ,&nbsp;Julia Badzińska ,&nbsp;Helena Bieniek ,&nbsp;Justyna Brączyk ,&nbsp;Daryna Rubanets ,&nbsp;Karolina Wiercioch-Kuzianik ,&nbsp;Magdalena Żegleń ,&nbsp;Anna Przeklasa-Muszyńska ,&nbsp;Lance M. McCracken ,&nbsp;Przemysław Bąbel","doi":"10.1016/j.exger.2025.112886","DOIUrl":"10.1016/j.exger.2025.112886","url":null,"abstract":"<div><h3>Background</h3><div>Chronic pain remains a significant health concern, particularly among older adults. Pain acceptance – engaging in valued activities despite pain without attempting to control or avoid it – is thought to buffer against the negative psychosocial impacts of chronic pain.</div></div><div><h3>Objective</h3><div>The present study aimed to adapt to Polish and evaluate the psychometric properties of a widely used measure of pain acceptance, namely the Chronic Pain Acceptance Questionnaire (CPAQ).</div></div><div><h3>Methods</h3><div>Two samples of individuals with chronic pain participated: an online sample (<em>N</em> = 418) and a hospital-recruited sample (<em>N</em> = 148). Confirmatory factor analyses assessed one-factor, two-correlated-factor, and two-orthogonal-factor models for both the original 20-item (CPAQ-20) and the short 8-item (CPAQ-8) versions.</div></div><div><h3>Results</h3><div>In both samples, the results consistently supported a two-factor correlated structure for the Polish CPAQ-8: Activity Engagement (AE) and Pain Willingness (PW). The CPAQ-20 did not show adequate fit. The CPAQ-8 demonstrated acceptable-to-good internal consistency (Cronbach's α = 0.63-0.78 total; 0.75-0.82 subscales) and moderate test–retest reliability (ICC = 0.57). The Minimal Detectable Change for the total score was 9.34 points. In the online sample, CPAQ-8 scores negatively correlated with pain anxiety, pain catastrophizing, anxiety, and depression. Across both samples, total CPAQ-8 and PW scores, but not AE, were negatively associated with pain. Participants reporting activity limitations scored significantly lower on CPAQ-8. Additionally, age was positively correlated with AE scores in both samples.</div></div><div><h3>Conclusions</h3><div>Overall, the Polish CPAQ-8 exhibits good psychometric properties and is suitable for both research and clinical applications. Future studies should examine its longitudinal validity.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112886"},"PeriodicalIF":4.3,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population\" [Exp. Gerontol. 197 (2024) 112585].","authors":"Indranath Chatterjee, Videsha Bansal","doi":"10.1016/j.exger.2025.112889","DOIUrl":"10.1016/j.exger.2025.112889","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112889"},"PeriodicalIF":4.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}