Experimental gerontology最新文献

{"title":"Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study.","authors":"Shiyi Shan, Weidi Sun, Jing Wu, Leying Hou, Zeyu Luo, Jiali Zhou, Jiayao Ying, Peige Song","doi":"10.1016/j.exger.2025.112791","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112791","url":null,"abstract":"<p><strong>Background: </strong>As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases.</p><p><strong>Methods: </strong>In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women were included. ALLB was further classified equally into tertiles (<26 years, 26-29 years, and ≥30 years). Total stroke and its three subtypes (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were identified as outcomes. Cox proportional hazard regression was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations of ALLB with incident stroke and its subtypes. Latent class analysis (LCA) was employed to explore underlying socioeconomic status (SES) classes within women in urban and rural areas, and SES-stratified analysis was conducted. Population attributable fraction (PAF) was estimated to assess the impact of later ALLB on stroke at the population level.</p><p><strong>Results: </strong>Compared with women with ALLB of <26 years, women with later ALLB (26-29 years and ≥ 30 years) faced a higher risk of stroke, with the highest fully adjusted HRs (aHRs) observed in women with an ALLB of ≥30 years (total stroke: 3.88, 95 % CI 3.71-4.07; IS: 5.33, 95 % CI 5.05-5.63; ICH: 3.79, 95 % CI 3.36-4.29; SAH: 4.93, 95 % CI 3.41-7.12). The strongest associations were found among rural-low-SES participants with total stroke and IS, with aHRs of 5.61 (95 % CI 5.12-6.16) and 7.28 (95 % CI 6.51-8.14) for an ALLB of ≥30 years. The highest PAF of total stroke with ALLB ≥26 years was observed in rural-middle-SES individuals, with value of 59.15 % (95 % CI 56.80-61.48).</p><p><strong>Conclusion: </strong>Later ALLB was associated with an increased risk of stroke among Chinese parous postmenopausal women, notably in lower socioeconomic rural populations.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112791"},"PeriodicalIF":3.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of metformin on serum miRNA expression and target gene regulation in prediabetic patients.","authors":"Chunxiao Wang, Li Li, Zhi Yang, Lina Wang, Yonghua Liu, Peng Duan, Jiang Liu, Nijia Meng, Tongxi Zhou","doi":"10.1016/j.exger.2025.112792","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112792","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes, also known as impaired glucose tolerance (IGT), is a common metabolic disorder and is often considered a risk factor for the development of diabetes. Metformin (MET) is a widely used medication for the treatment of diabetes and has the potential to improve insulin sensitivity and blood sugar control. This work aimed to investigate the impact of MET treatment on serum miRNA expression in IGT patients and explore the quantitative changes in miRNA after MET treatment.</p><p><strong>Methods: </strong>Peripheral blood samples were collected from 6 prediabetic patients, and serum miRNA expression was analyzed before and after MET treatment. Differentially expressed miRNAs were identified, and gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analyses were performed to explore the biological processes and pathways involved.</p><p><strong>Results: </strong>Fourteen miRNAs (8 upregulated and 6 downregulated) were identified in IGT patients. The top 5 miRNAs based on differential fold change (FC) were identified. Following MET treatment, hsa-miR-455-5p, hsa-miR-505-3p, hsa-miR-21-5p, and hsa-miR-33a-5p were downshifted, while hsa-miR-96-5p was increased in patients (P < 0.05). The differentially expressed miRNAs were linked with collagen catabolic process (CCP), postsynaptic density (PD), and extracellular matrix structural constituent (EMSC). Enrichment analysis (EA) revealed involvement in signaling pathways like advanced glycation end products (AGEs) and their receptor (RAGE) signaling pathway in diabetic complications, signaling pathways regulating pluripotency of stem cells, and TNF signaling pathway.</p><p><strong>Conclusion: </strong>MET modulates miRNA expression in prediabetic patients, potentially influencing pathways related to insulin sensitivity and metabolic regulation. These findings may guide future therapeutic strategies for early diabetes intervention.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112792"},"PeriodicalIF":3.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in prevalence of loneliness among home-dwelling older adults over three decades and associated factors","authors":"Mia T. Knuutila ,&nbsp;Laura J. Rautiainen ,&nbsp;Ulla L. Aalto ,&nbsp;Tuuli E. Lehti ,&nbsp;Helena Karppinen ,&nbsp;Hannu Kautiainen ,&nbsp;Timo E. Strandberg ,&nbsp;Hanna Reeta Öhman ,&nbsp;Niina M. Savikko ,&nbsp;Anu H. Jansson ,&nbsp;Kaisu H. Pitkälä","doi":"10.1016/j.exger.2025.112790","DOIUrl":"10.1016/j.exger.2025.112790","url":null,"abstract":"<div><h3>Background</h3><div>Studies examining loneliness trends over several decades among comparable cohorts of older people are rare.</div></div><div><h3>Objective</h3><div>We evaluated how the prevalence of self-reported loneliness has changed over three decades among home-dwelling older people (75+ years), and factors associated with loneliness.</div></div><div><h3>Methods</h3><div>We used data from four waves of the Helsinki Aging Study (1989-present), a repeated cross-sectional cohort study. The data had been collected using a postal questionnaire. The sample sizes were: 1989 (<em>n</em> = 660), 1999 (<em>n</em> = 2598), 2009 (<em>n</em> = 1637), 2019 (<em>n</em> = 1758). Based on responses to the question “Do you suffer from loneliness?”, we categorized the respondents into lonely (‘always or often’, ‘sometimes’) and not lonely (‘seldom or never’). The associations between various characteristics and loneliness were explored.</div></div><div><h3>Results</h3><div>The prevalence of loneliness among older people decreased slightly between 1989 and 2019, from 34 % to 30 %. Loneliness decreased among both sexes. In the multivariable forward stepwise regression model, factors associated with loneliness were widowhood (OR 2.18, 95 % CI 1.91–2.49), needing help daily (OR 1.83, 95 % CI 1.56–2.16), feeling depressed (OR 5.26, 95 % CI 3.56–7.77), comorbidities (OR 1.07, 95 % CI 1.03–1.11), feeling useful (OR 0.36, 95 % CI 0.31–0.41), meeting friends (OR 0.65, 95 % CI 0.57–0.74), and male sex (OR 0.69, 95 % CI 0.59–0.80).</div></div><div><h3>Conclusions</h3><div>Loneliness among both older men and women has decreased over the past three decades. Several factors were found to be associated with loneliness. Given the detrimental impact of loneliness on health of individuals, policies and health strategies aimed at alleviating loneliness among older people should be a top priority.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112790"},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological alterations and gene expression levels in the cerebral cortex causally influence susceptibility to type 2 diabetes: A Mendelian randomization study","authors":"Fanghang Ye ,&nbsp;Yucheng Huang ,&nbsp;Na Li ,&nbsp;Liyuan Hao ,&nbsp;Jiali Deng ,&nbsp;Shenghao Li ,&nbsp;Jiayun Yue ,&nbsp;Fei Yu ,&nbsp;Xiaoyu Hu","doi":"10.1016/j.exger.2025.112789","DOIUrl":"10.1016/j.exger.2025.112789","url":null,"abstract":"<div><h3>Background</h3><div>The associations between type 2 diabetes (T2D) and neurological as well as psychiatric disorders have garnered growing interest. Previous evidence has indicated a correlation between the cerebral cortex and these conditions. However, the causal direction between the cerebral cortex and T2D remains ambiguous.</div></div><div><h3>Methods</h3><div>We conducted a cerebral cortex-focused systematic Mendelian randomization (MR) study based on multiple data sourced from genome-wide association studies and expression quantitative trait locus.</div></div><div><h3>Results</h3><div>The surficial area (SA) of Pars Opercularis and the thickness (TH) of the Supramarginal gyrus were found as significant contributors to the risk of T2D. Conversely, thickening in the Precentral area, Caudal Anterior Cingulate cortex, and banks of the Superior Temporal Sulcus, as well as SA amplification of the Precentral area, were associated with a reduced risk of T2D. There was no evidence of reverse causation. These alterations also have an impact on susceptibility to T2D complications. Combining the summary-data-based MR (SMR) analysis and colocalization analysis, we prioritized the expression of three causal genes in the cerebral cortex with genetic evidence for influencing T2D susceptibility. Elevated expression levels of <em>NUDC</em> and <em>PACC1</em> increased susceptibility to T2D, whereas <em>RAB29</em> expression exhibits an inverse association with T2D susceptibility. Mediation MR analysis revealed that TH of the Banks of the Superior Temporal Sulcus, SA of Precentral area, SA of Pars Opercularis, and SA of Supramarginal gyrus mediated the effect of <em>RAB29</em> on T2D. Cross-tissue colocalization analysis demonstrated that the expression pattern of <em>NUDC</em> displayed brain tissue specificity. <em>PACC1</em> and <em>RAB29</em> also exhibited colocalization signals in several specific tissues beyond brain tissue. The phenome-wide association study suggested that these genes underscore the shared genetic burden of T2D with a range of disease phenotypes including mental disorders, cardiovascular disease, and malignancies.</div></div><div><h3>Conclusions</h3><div>These findings underscore the novel role of the central nervous system in genetic liability to T2D and provide valuable clues for future mechanism studies.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112789"},"PeriodicalIF":3.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis","authors":"Zhi Liu ,&nbsp;XiangMing Chen ,&nbsp;Zhe Ruan ,&nbsp;Chao Wang ,&nbsp;Dongliang Yuan ,&nbsp;Wenfeng Xiao ,&nbsp;Yusheng Li ,&nbsp;Shushan Zhao","doi":"10.1016/j.exger.2025.112788","DOIUrl":"10.1016/j.exger.2025.112788","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA), sarcopenia (SCP), and osteoporosis (OP) pose a substantial global morbidity and mortality burden, and previous studies have observed potential associations among them. This study aims to comprehensively characterize the common genetic structure, biological basis, and underlying causal relationship among OA, SCP, and OP.</div></div><div><h3>Methods</h3><div>We used pooled statistics from the largest European genome-wide association study to investigate the genetic overlap and underlying causal relationships among OA, SCP, and OP. LD Score Regression (LDSC) was first used for estimating global and local genetic associations, cross-trait meta-analysis was then conducted to identify shared loci, and mendelian randomization (MR) analysis was performed to test causal association.</div></div><div><h3>Results</h3><div>In global and local genetic correlation analysis, we found strong positive correlations among OA, SCP, and OP. Cross-trait meta-analysis revealed 9 novel pleiotropic loci for HandOA_SCP trait-pairs, 1 for ThumbOA_SCP (females), and 6 for KneeOA_SCP (males)0.10 novel pleiotropic loci were also identified for HipOA_TBMD, while none for WLM_FinOP. Bidirectional MR analyses indicated significant causal associations between HandOA and SCP(Forward: OR: 1.41, 95 % CI: 1.25–1.60, <em>p</em> &lt; 0.01,Reverse: OR: 1.77, 95 % CI: 1.34–2.35, <em>p</em> &lt; 0.01). Reverse analyses suggested that ThumbOA.female (OR: 1.92, 95 % CI:1.18–3.13, <em>p</em> &lt; 0.01) and KneeOA.male (OR: 1.58, 95 % CI: 1.13–2.12, <em>p</em> &lt; 0.01) were positively correlated with SCP, while TBMD was positively correlated with HipOA (OR: 1.23, 95 % CI: 1.16–1.31, <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Our work demonstrates a shared genetic basis, pleiotropic loci, and putative causal relationships among OA, SCP, and OP, highlighting the intrinsic links behind these three complex skeletal diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112788"},"PeriodicalIF":3.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we underestimating cardiovascular risks in midlife women? A call for gender-specific strategies","authors":"Madhan Krishnan,&nbsp;Shyamaladevi Babu","doi":"10.1016/j.exger.2025.112787","DOIUrl":"10.1016/j.exger.2025.112787","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112787"},"PeriodicalIF":3.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VPS33B-dependent exosomes modulate cellular senescence of mesenchymal stem cells via an autocrine signaling pathway","authors":"Hehe Wang ,&nbsp;Qi Tan ,&nbsp;Yijuan Duan ,&nbsp;Mingduo Wu ,&nbsp;Bin Zuo ,&nbsp;Jiao Li","doi":"10.1016/j.exger.2025.112786","DOIUrl":"10.1016/j.exger.2025.112786","url":null,"abstract":"<div><div>Mesenchymal stem cell (MSC)-derived exosomes have been intensively studied for their therapeutic effects on tissue repair and regeneration. However, the specific contributions of exosomes derived from endogenous bone marrow MSCs to the maintenance of bone tissue homeostasis remain unclear. In this study, we impaired MSC-derived exosome secretion by specifically deleting vascular protein sorting 33B (VPS33B). Mice deficient in VPS33B (VPS33B-cKO mice) exhibited premature bone loss and imbalanced bone remodeling processes, which were associated with a reduction in MSC number and an increase in bone marrow inflammation. MSCs derived from VPS33B-cKO mice exhibited impaired self-renewal, proliferation, osteoblastic differentiation, and increased cellular senescence. Incubation with exosomes (Y-Exo) derived from MSCs of wildtype young mice greatly ameliorated senescent phenotypes observed in VPS33B-deficient MSCs. We further demonstrated exosome autocrine pathway through a fluorescent-labeled uptake assay and observed a significant association between autocrinal exosomes and the senescence of MSCs. Mechanistically, miR-136-3p and miR-146a-5p were highly enriched in Y-Exo but not in exosomes from senescent MSCs, which promoted cell proliferation while inhibiting inflammation by targeting the PI3K-Akt and NF-κB pathway, respectively. Furthermore, intramedullary transplantation of Y-Exo successfully mitigated age-related MSC exhaustion and bone loss. Our findings indicate that endogenous MSC-derived exosomes play a crucial regulatory role in the maintenance of bone homeostasis, and propose the potential therapeutic application of young MSC-derived exosomes for the treatment of senile osteoporosis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112786"},"PeriodicalIF":3.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between diffusion MRI-based measures of neurite microstructure and risk of Alzheimer's disease","authors":"Sasha Hakhu,&nbsp;Andrew Hooyman,&nbsp;Jennapher Lingo VanGilder,&nbsp;Sydney Y. Schaefer,&nbsp;Scott C. Beeman,&nbsp;Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.exger.2025.112782","DOIUrl":"10.1016/j.exger.2025.112782","url":null,"abstract":"<div><div>Early detection of Alzheimer's disease (AD) is crucial for intervention, but traditional MRI and cognitive assessments may miss pre-symptomatic changes. Advanced diffusion MRI (dMRI) methods, such as Neurite Orientation Dispersion and Density Imaging (NODDI), show promise in identifying early brain changes. We analyzed 65 cognitively unimpaired older adults (25 APOE-e4 carriers, 40 non-carriers) from the ADNI3 dataset. NODDI's neurite density index (NDI) and orientation dispersion index (ODI), volumetric MRI and cognition (MoCA) were analyzed in key brain regions like the hippocampus, fusiform gyrus, and entorhinal cortex. Statistical analyses included linear regression and <em>t</em>-tests, with FDR correction. NDI differed significantly between carriers and non-carriers and correlated with MoCA scores. ODI differed only in the CA1 hippocampal subfield. Volumetric MRI measures showed no group differences. Significant APOE-e4 group differences were observed in NDI for the left fusiform gyrus (β = 0.015, p = 0.02), right fusiform gyrus (β = 0.018, p = 0.02), left entorhinal cortex (β = 0.018, p = 0.04), right entorhinal cortex (β = 0.018, p = 0.03), left CA1 (β = 0.03, p = 0.02), and left CA2–3 (β = 0.03, p = 0.02). ODI differences were observed only in left CA1 (β = 0.037, p = 0.008). No volumetric measures differed significantly. MoCA correlated with NDI in bilateral entorhinal cortices (p = 0.001–0.05), left fusiform gyrus (p = 0.02), and right CA2–3 (p = 0.02). NODDI metrics, particularly NDI, could help detect early APOE-e4-related microstructural changes, while traditional volumetric MRI measures remain uninformative at early stages.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112782"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases","authors":"Feixiang Yang ,&nbsp;Xiangyu Zhang ,&nbsp;Wei Dai ,&nbsp;Ke Xu ,&nbsp;Yunyun Mei ,&nbsp;Tianrui Liu ,&nbsp;Kun Wang ,&nbsp;Qianjun Liang ,&nbsp;Peng Guo ,&nbsp;Chaozhao Liang ,&nbsp;Jialin Meng","doi":"10.1016/j.exger.2025.112783","DOIUrl":"10.1016/j.exger.2025.112783","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia is a prevalent age-related disorder characterized by progressive loss of muscle mass, strength, and physical performance. While genome-wide association studies (GWAS) have explored isolated traits, the multifactorial genetic architecture underlying sarcopenia remains poorly defined. In this study, we constructed a comprehensive genetic factor to explain the genetic architecture of sarcopenia, and explore causal associations, genetic comorbidities, and mediating pathways linking sarcopenia to 30 urological diseases.</div></div><div><h3>Methods</h3><div>Based on the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, six sarcopenia-related phenotypes were selected. A multivariate GWAS framework using genomic structural equation modeling (genomic SEM) was constructed, with an effective sample size of 651,820 individuals. Bidirectional Mendelian randomization (MR) was employed to assess causal relationships between sarcopenia and 30 urological diseases. Genetic correlation, tissue-specific heritability enrichment, shared risk genes, and gene set enrichment analyses were conducted to dissect genetic comorbidities between sarcopenia and urological diseases. Multi-omic mediation analysis was conducted to identify potential pathways mediated by blood proteins, metabolites, and immune traits.</div></div><div><h3>Results</h3><div>Multivariate GWAS identified 215 loci and 30,869 single-nucleotide polymorphisms (SNPs) associated with polygenic architecture of sarcopenia. Bidirectional Mendelian randomization revealed causal links between sarcopenia and urological diseases, notably hyperplasia of prostate (BPH; OR = 1.17, <em>P</em> = 0.043) and acute tubulointerstitial nephritis (ATIN; OR = 1.14, <em>P</em> = 0.028). Genetic comorbidity analyses identified local genetic correlations between sarcopenia and BPH, and highlighted tissue-specific heritability enrichment in <em>Cells Cultured fibroblasts</em> tissue for both traits, while no genetic correlation was found with ATIN. We identified 75 shared risk genes for sarcopenia and BPH, which were enriched in cellular component biogenesis, RNA binding, and metabolic pathways. Multi-omic mediation analyses prioritized 17 metabolites and proteins linking sarcopenia to BPH and ATIN, though no significant immune mediators were identified.</div></div><div><h3>Conclusion</h3><div>These findings unveil a shared genetic architecture between sarcopenia and urological diseases, especially BPH, with heritability enrichment in fibroblast tissue and metabolic dysfunction emerging as the significant overlapping pathway.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112783"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of commonly used assessment methods for predicting fall risk in the elderly","authors":"Aziz DENGİZ ,&nbsp;Ahmet AYTEPE ,&nbsp;Bayram SIRRI ,&nbsp;Mehmet EFE","doi":"10.1016/j.exger.2025.112784","DOIUrl":"10.1016/j.exger.2025.112784","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the effectiveness of four different commonly used assessment methods Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Modified Falls Efficacy Scale (MFES), and Morse Fall Scale (MFS) in predicting fall risk in elderly.</div></div><div><h3>Method</h3><div>The study included 195 participants (97 female, mean age: 69.82 ± 7.45 years) aged 60 and above. The BBS, TUG, MFES, and MFS were used to asses fall risk. Logistic regression analysis was conduct.</div></div><div><h3>Results</h3><div>The addition of independent variables significantly reduced the −2 Log Likelihood value (from 222.015 to 49.196), and the Nagelkerke R² value was 0.865. The Hosmer-Lemeshow goodness-of-fit test (<em>p</em> = .738) and ROC analysis (AUC 0.958–0.972) confirmed the model's strong fit and high discriminative power. The MFS (B = 0.120, <em>p</em> = .001, Exp(B) = 1.128) and the TUG(B = 0.542, <em>p</em> = .004, Exp(B) = 1.720) were significantly associated with fall risk. In contrast, the MFES and BBS did not show statistically significant effects.</div></div><div><h3>Conclusions</h3><div>The MFS and TUG are particularly effective in identifying fall risk in elderly individuals. However, using these tests alone may have limited predictive power, highlighting the importance of a multidisciplinary approach for fall risk assessment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112784"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}