Experimental gerontology最新文献

{"title":"Association between body roundness index trajectories and successful aging among older adults in China: A nationally representative longitudinal cohort study.","authors":"Kangle Wang, Huanghao Zhou, Jiale Peng, Lixin Wu, Hao Liu, Kaifeng Xu, Lidian Chen, Zhizhen Liu","doi":"10.1016/j.exger.2025.112921","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112921","url":null,"abstract":"<p><strong>Background: </strong>Successful aging involves maintaining physical vitality, emotional health, and meaningful social connections throughout late life. Body Roundness Index (BRI), a numerical indicator of body shape, is drawing growing interest as a potential marker for evaluating successful aging. Drawing on data from the China Health and Retirement Longitudinal Study (CHARLS), this research examined how BRI trajectory patterns were associated with successful aging in the older Chinese population.</p><p><strong>Methods: </strong>The analysis included 2517 individuals aged 60 and above, drawn from the CHARLS cohort. BRI was measured in 2011, 2013, and 2015, and its longitudinal patterns were determined through group-based trajectory modeling (GBTM). Successful aging was assessed at the 2018 follow-up. To investigate the link between BRI trajectories and successful aging, we employed binary logistic regression, supplemented by subgroup and interaction analyses to test for effect modification.</p><p><strong>Findings: </strong>Three distinct BRI trajectories were identified: low-stable (46.9 %), intermediate-stable (43.0 %), and high-rising (10.1 %). The intermediate-stable group had the greatest odds of successful aging compared to the high-rising group, followed by the low-stable group with a moderately lower likelihood. Upon controlling for a range of covariates, individuals in the intermediate-stable group and the low-stable group had significantly greater odds of successful aging, with ORs of 2.63 (95 % CI: 1.45-5.12, P = 0.002) and 2.52 (95 % CI: 1.26-5.31, P = 0.012), respectively. Across sensitivity analyses, the intermediate-stable trajectory showed the strongest and most consistent association with successful aging.</p><p><strong>Conclusion: </strong>This study highlights the need to monitor body changes in older adults and develop targeted health strategies to support successful aging.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112921"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant-induced autophagy ameliorates oxidative mediated endoplasmic reticulum stress in ultraviolet-B-exposed human primary dermal fibroblasts.","authors":"Sheikh Umar Ahmad, Aalim Maqsood Bhat, Gupta Ragni, Malik Ahmad Mushtaq, Sheikh Tasduq Abdullah","doi":"10.1016/j.exger.2025.112922","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112922","url":null,"abstract":"<p><p>Exposure to ultraviolet-B (UVB) radiation is a major contributor to skin damage and photoaging. UVB primarily induces oxidative stress and endoplasmic reticulum (ER) stress, leading to DNA instability and cellular dysfunction. Elevated reactive oxygen species (ROS) levels disrupt cellular homeostasis and activate stress-response pathways that exacerbate damage. While the effects of UVB-induced stress are well documented, strategies that enhance antioxidant defenses to simultaneously mitigate oxidative and ER stress while promoting cellular repair mechanisms, such as autophagy, remain underexplored. In this study, we investigated the protective role of antioxidant-mediated autophagy in UVB-exposed primary human dermal fibroblasts (HDFs). Our results show that UVB irradiation markedly increases ROS accumulation, triggering ER stress and DNA damage, ultimately impairing cell viability. Pharmacological enhancement of antioxidant defenses using Trolox, a vitamin E analog (α-tocopherol), effectively reduced ROS levels, alleviated oxidative and ER stress markers, and restored cellular homeostasis. Importantly, this intervention also activated autophagy, revealing a synergistic mechanism by which antioxidant and autophagic responses cooperate to protect cells. These findings establish a mechanistic link between autophagy activation and the alleviation of oxidative stress-induced ER stress, highlighting a coordinated cellular defense that mitigates DNA damage in HDFs. Collectively, our study provides valuable insights into potential therapeutic strategies aimed at enhancing skin resilience and protecting against UVB-induced damage.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112922"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EpiClock; biological age measurement from blood DNA methylation using a minimal CpG marker set for high-throughput iPlex mass spectrometry assay for screening in drug development and population health.","authors":"Hyojung Kim, Ah-Hyun Park, Minjae Kwon, Kyoung Joo Lee, Min-Jeong Kim, Min-Seob Lee","doi":"10.1016/j.exger.2025.112918","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112918","url":null,"abstract":"<p><p>Measuring biological aging-the underlying rate of physiological decline-has become increasingly important in predicting disease risk, guiding personalized health strategies, and advancing age-targeted therapeutics. Unlike chronological age, biological age provides a more accurate reflection of an individual's functional health and longevity potential. DNA methylation-based epigenetic clocks are established tools for estimating biological age, but existing assays often require hundreds to thousands of CpG sites, resulting in high costs, complex analysis, and poor scalability. These limitations hinder their practical use in large-scale population screening and routine clinical applications. To address this gap, we developed EpiClock, a streamlined and cost-effective biological age prediction model based on just eight age-associated CpG markers (ASPA, FHL2, MIR29B2CHG, Chr16q24.1, SLC12A5, SST, LDB2, and COL1A1) from blood-derived DNA. The model showed high accuracy (R² = 0.9332; mean absolute deviation (MAD) = 3.78 years), strong inter-operator reproducibility (R² = 0.9667), and robust intra-assay precision (CV < 6 %, SD ≤ 0.05), with optimal performance using buffy coat samples. By combining a minimal marker set with high analytical reliability, EpiClock enables scalable, high-throughput biological age assessment-supporting its use in drug development, population-level screening, and accessible precision aging diagnostics.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112918"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Healthy Aging Index with all-cause mortality: Results from the Korean frailty and aging cohort study.","authors":"Jinhee Kim, Yunhwan Lee, Eunsaem Kim, Seri Hong, Miji Kim","doi":"10.1016/j.exger.2025.112925","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112925","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the association between the Healthy Aging Index (HAI) and all-cause mortality and its potential modification by sociodemographic or lifestyle factors.</p><p><strong>Methods: </strong>We analyzed data from 2303 community-dwelling adults aged 70-84 years who participated in the Korean Frailty and Aging Cohort Study (2016-2023). The HAI was constructed using five domains-physical function, cognitive function, social well-being, psychological health, and physiological health-each scored from 0 to 3. The total HAI score (range: 0-15) was evaluated as a continuous variable and by tertiles (poor, 0-9; moderate, 10-11; high, 12-15 points). All-cause mortality was assessed biennially from 2018 to 2023 from family or neighbor interviews or electronic medical records. Cox proportional hazards regression models were used for statistical analyses.</p><p><strong>Results: </strong>During the 6-year follow-up, 152 (6.6 %) participants died. After adjusting for covariates, each 1-point increase in HAI was associated with an 18 % lower risk of all-cause mortality (hazard ratio [HR], 0.82; 95 % confidence interval [CI]: 0.76-0.88). Compared with the high HAI group, the HRs for the moderate and poor HAI groups were 1.27 (95 % CI: 0.70-2.28) and 2.77 (95 % CI: 1.58-4.88), respectively (P for trend <0.001). HAI and educational level showed a significant interaction.</p><p><strong>Conclusions: </strong>Lower levels of healthy aging were associated with higher mortality, particularly among older adults with lower educational attainment. These findings highlight the need for targeted strategies to promote healthy aging, especially among those with lower levels of education.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112925"},"PeriodicalIF":4.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compromised autophagy in the aging epididymis: Evidence and relevance to male fertility.","authors":"Nabil Eid","doi":"10.1016/j.exger.2025.112920","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112920","url":null,"abstract":"<p><p>Impaired autophagy and increased cellular senescence in the aging epididymis may lead to cellular stress, inflammation, and epithelial dysfunction. This reduction in autophagy can be identified using light and electron microscopy, as well as molecular biology techniques. Autophagy, which may be selective or non-selective, is tightly regulated by genes such as LC3 and LAMP-2. Decreased autophagic activity in the epididymis results in reduced sperm quality and male fertility. These findings highlight autophagy as a potential therapeutic target in age-related male reproductive decline.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112920"},"PeriodicalIF":4.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of clinical trials on lavender for sleep disorders in the elderly.","authors":"Mohadeseh Ostovar, Mohammad Hamed Khademizadeh, Foroogh Namjoyan, Asma Kazemi, Sina Vakili, Seyed Hamdollah Mosavat, Mohsen Mohit, Mohammad Hashem Hashempur","doi":"10.1016/j.exger.2025.112919","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112919","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to gather existing findings related to the effect of lavender on improving sleep disorders in older adults.</p><p><strong>Methods: </strong>In this systematic review, PubMed, Web of Science, Embase, and Scopus databases were searched using keywords ((lavender OR Lavandula) AND (sleep OR insomnia OR \"sleep disturbance\" OR \"sleep quality\" OR \"sleep disorder\") AND (elderly OR elder OR aging OR aging OR \"older adult\" OR geriatric OR geriatrics)) from their inception up to August 20, 2025. Only clinical trials evaluating the effect of lavender on aged patients (more than 60 years old) with sleep disorders were included. Then, data about drug formulation, dosage, duration of treatment, measurements, findings, and adverse events were recorded. A random-effects meta-analysis was used to calculate the pooled standardized mean differences (SMD) and their corresponding 95 % confidence intervals (CI).</p><p><strong>Results: </strong>In this study, 84 articles were evaluated, and ten articles were selected for full review. In nine studies (90 %), lavender significantly improved sleep disorders. The most used scale among the articles was the Pittsburgh Sleep Quality Index (PSQI), which was used in seven studies (70 %). All the studies reported using lavender in the medicinal form of inhalation. The results of the meta-analysis indicated a significant improvement in the total score of sleep quality (SMD: -1.20, 95 % CI: -1.73, -0.68, I²: 87.5 %), with a more pronounced effect observed in studies that utilized the PSQI questionnaire.</p><p><strong>Conclusion: </strong>Based on preliminary evidence from this review, lavender may effectively treat sleep disorders, especially in the elderly. However, more research is required to fully understand its effectiveness and safety, especially with long-term use.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112919"},"PeriodicalIF":4.3,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between anemia and stroke with its subtypes in adults: Insights from NHANES 2005–2016 and Mendelian randomization analyses","authors":"Qizhao Li ,&nbsp;Shuai Wang ,&nbsp;Wenjuan Gao ,&nbsp;Yuying Wei ,&nbsp;Xiao Gao ,&nbsp;Puzhou Wang ,&nbsp;Johan Rebetz ,&nbsp;Elisabeth Semple ,&nbsp;Li Guo ,&nbsp;John W. Semple ,&nbsp;Joaquín Martínez-López ,&nbsp;Jun Peng ,&nbsp;Shuqian Xu","doi":"10.1016/j.exger.2025.112916","DOIUrl":"10.1016/j.exger.2025.112916","url":null,"abstract":"<div><div>Stroke and anemia are both prevalent conditions with significant health burdens, yet their bidirectional relationship remains poorly understood. Anemia affects up to 29 % of stroke patients and is associated with increased worse outcomes. However, the causal nature of this association, particularly concerning different anemia subtypes, remains controversial, and there is a lack of clear targets and specific treatments for anemia in stroke patients. This study employed data from National Health and Nutrition Examination Survey (NHANES) database and two sample Mendelian randomization (MR) to investigate the relationship between different types of anemia, particularly aplastic anemia (AA) and iron deficiency anemia (IDA), and the risk of stroke and its subtypes in adults. The study included 7931 participants (3824 male and 4107 female) from NHANES (2005–2016). After adjusting for all covariates, the exposure factor of stroke was significantly positively correlated with the risk of anemia in middle-aged and elderly females, while in males, although the correlation was not significant, it was close to the threshold (OR = 1.66, 95 % CI = 0.987–2.78, <em>P</em> = 0.0558 in male. OR = 2.36, 95 % CI = 1.35–4.14, <em>P</em> &lt; 0.01 in female at model 3). Genetically instrumented total anemia risk was nominally associated with risk of stroke (<em>P</em> = 0.086), IDA (OR = 1.413, ARI = 0.0407, 95 % CI = 1.318–1.515, <em>P</em> &lt; 0.001) and AA (OR = 1.057, ARI = 0.0058, 95 % CI = 1.002–1.116, <em>P</em> = 0.04) were significantly associated with stroke risk. Furthermore, both genetic instrumented IDA and AA were significantly associated with an increased risk of large artery stroke but not with other stroke subtypes, in a unidirectional manner. The reverse MR analyses showed that genetically predicted stroke risk also associated with increased risk of total anemia (OR = 1.005, ARI =0.0050, 95 % CI = 1.003–1.007, <em>P</em> &lt; 0.001), as well as with subtypes of anemia (IDA: OR = 1.038, ARI =0.0366, 95 % CI = 1.002–1.075, <em>P</em> = 0.037; AA: OR = 1.240, ARI =0.1935, 95 % CI = 1.062–1.447, <em>P</em> = 0.012). In conclusion, a bidirectional association between increased risk of two types of anemia and elevated stroke risk was observed, with varying magnitudes of effect. Randomized trials are now needed to assess the effects of different treatments for anemia on stroke and its subtypes, particularly in high-risk older individuals.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"211 ","pages":"Article 112916"},"PeriodicalIF":4.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Link between triglyceride-glucose-body mass index and future cardiovascular disease risk in Chinese menopausal women: A nationwide prospective cohort study.","authors":"Daoyuan Wei, Weiqi Zhu, Xinyu Yang, Yuanxiang Liu, Jiguo Yang","doi":"10.1016/j.exger.2025.112906","DOIUrl":"10.1016/j.exger.2025.112906","url":null,"abstract":"<p><strong>Background: </strong>The association between the triglyceride glucose-body mass (TyG-BMI) index and cardiovascular disease (CVD) risk in postmenopausal women remains unclear. This study examines this association in Chinese menopausal women to develop targeted risk assessment tools.</p><p><strong>Methods: </strong>Data from the 2011 and 2020 China Health and Retirement Longitudinal Study (CHARLS) included menopausal women aged ≥45 years. Multivariable logistic regression models assessed the association between TyG-BMI and CVD. Restricted cubic spline (RCS) regression tested nonlinearity, and stratified analyses evaluated effect modification.</p><p><strong>Results: </strong>Among 2405 participants, 609 (25.32 %) developed CVD. Each interquartile TyG-BMI (49.10) increase raised CVD risk by 28 % (OR = 1.28; 95 % CI: 1.07-1.53). A linear dose-response relationship existed for CVD (P-trend <0.05; P-nonlinearity >0.05). Marital status modified the association (P-interaction = 0.035), with no significant interactions in other subgroups. For CVD prediction, TyG-BMI (AUC = 0.645) outperformed TyG (AUC = 0.622).</p><p><strong>Conclusions: </strong>Our study demonstrates a significant association between TyG-BMI and the risk of CVD in postmenopausal women, supporting its utility as a valuable biomarker for enhancing primary prevention and management strategies in this population.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112906"},"PeriodicalIF":4.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in prolonged walking intensity and duration between older people reporting difficulty, modifications or no difficulty in walking.","authors":"Heli Peltomaa, Merja Rantakokko, Emmi Matikainen-Tervola, Timo Aittokoski, Taina Rantanen, Laura Karavirta","doi":"10.1016/j.exger.2025.112914","DOIUrl":"10.1016/j.exger.2025.112914","url":null,"abstract":"<p><p>Older people report modifying their walking by slowing down speed or using walking aids to accommodate increased exertion and the decline in physical capacity. Self-reported walking modifications and difficulties are associated with daily walking accumulation; however, the relationship between self-reported walking ability and prolonged walking intensity and duration is not well understood. This cross-sectional study compared walking speed, duration, and changes in intensity during prolonged walking bout between older people self-reporting walking difficulty, modifications, or no difficulty in walking. Participants (n = 104, 51 % women, age 78-90 years) performed a prolonged walking test at a constant speed based on Borg's rating of perceived exertion (RPE 13), walking at a constant speed until reaching RPE 16 or the maximum test duration (30 min). Wearable sensors recorded heart rate (HR), accelerometry, and cadence during the test. Walking speed was slower for older people reporting walking difficulty (1.17 ± 0.23) than for those reporting modifications (1.34 ± 0.19, p = 0.010) or no difficulty (1.42 ± 0.19, p < 0.001), which was similarly observed in accelerometry. No differences were found in walking duration (p = 0.205). Changes in RPE, HR, acceleration, and cadence did not differ between the walking ability categories. In conclusion, older people with self-reported walking difficulties were able to sustain the same perceived exertion level, but at a lower speed and acceleration, during prolonged walking as those without difficulties, for the same duration. These results highlight the importance of developing metrics for wearable sensors that reflect perceived exertion and its changes during prolonged activity bouts.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112914"},"PeriodicalIF":4.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between red blood cell distribution width (RDW), hemoglobin-to-RDW ratio (HRR), and mortality in hip fracture patients in the ICU: A MIMIC-IV database analysis.","authors":"Chin-Yi Liao, Yu-Der Lu, Yu-Jui Chang, Chih-Hsiang Hsu, Shan-Lin Hsu","doi":"10.1016/j.exger.2025.112917","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112917","url":null,"abstract":"<p><p>Hip fractures are associated with significant mortality, and hematologic indices such as red blood cell distribution width (RDW) and hemoglobin-to-RDW ratio (HRR) have shown potential as prognostic markers. However, their prognostic value in the intensive care unit (ICU) setting remains uncertain. This study aimed to explore the associations between RDW, HRR, and mortality in hip fracture patients requiring ICU admission. Data of patients with hip fractures admitted to the ICU were extracted from the MIMIC-IV database and retrospectively analyzed. The primary outcomes were 28-day and 1-year mortality. Associations between RDW, HRR, and mortality outcomes were evaluated using logistic regression and Cox proportional hazards models. A total of 488 patients were included. After adjustment, high RDW (≥ 14.3 %) was associated with significantly increased 28-day mortality (adjusted odds ratio [aOR] = 2.04, 95 % confidence interval [CI]: 1.07-3.88) and 1-year mortality (adjusted hazard ratio [aHR] = 1.95, 95 % CI: 1.15-3.29). High HRR (≥0.65 %) was independently associated with a reduced risk of 28-day mortality (aOR = 0.37, 95 % CI: 0.21-0.66) and 1-year mortality (aHR = 0.51, 95 % CI: 0.32-0.81) after adjusting for confounders. In conclusions, both RDW and HRR are independent predictors of mortality in patients with hip fractures admitted to the ICU. These indices could serve as a valuable prognostic tool in this patient population.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112917"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}