Experimental gerontology最新文献

{"title":"Task difficulty modulates motor learning benefits of balance exercises in community-dwelling older adults.","authors":"Kazunori Akizuki, Kosuke Takeuchi, Kazuto Yamaguchi, Ryohei Yamamoto, Wataru Nakano, Jun Yabuki","doi":"10.1016/j.exger.2025.112816","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112816","url":null,"abstract":"<p><strong>Purpose: </strong>Balance disorders are a major modifiable risk factor for falls, and balance exercises reduce fall rates. However, the effectiveness of balance exercises may depend on the relationship between the task difficulty and individual skill levels. This study aimed to explore the impact of task difficulty on the motor learning benefits of balance exercises.</p><p><strong>Methods: </strong>A sex-stratified, randomized, and non-blinded study was conducted among 40 community-dwelling older adults assigned to either a low- or high-difficulty balance exercise group. The task difficulty was manipulated by altering the support component affixed to an unstable board. Balance performance was measured using a stability index, and functional task difficulty was assessed using the National Aeronautics and Space Administration Task Load Index (NASA-TLX). The experiment included a pre-test, practice trials, and post-test conducted 24 h later. Statistical analyses included analysis of variance and regression analyses to examine the impact of task difficulty on motor learning and the relationship between motor learning benefits and task difficulty.</p><p><strong>Results: </strong>While both groups showed improved balance performance with practice, the low-difficulty group demonstrated greater motor learning benefits at the 24-h post-test (p < 0.001). Regression analysis showed a curvilinear relationship between the performance dimension score of the NASA-TLX and motor learning benefits (y = -0.017x² + 1.843x - 26.711, adjusted R² = 0.380, p < 0.001).</p><p><strong>Conclusion: </strong>In balance exercises for community-dwelling older adults, task difficulty significantly influences exercise intervention effectiveness. Our findings contribute to the development of personalized fall prevention programs that adjust task difficulty according to individual skill levels.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112816"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beam walking increases gait velocity and reduces falls risk in older adults","authors":"Ben Sidaway","doi":"10.1016/j.exger.2025.112814","DOIUrl":"10.1016/j.exger.2025.112814","url":null,"abstract":"<div><h3>Introduction</h3><div>A third of community-dwelling older adults will fall at least once per year, often during walking. In such individuals, the greatest postural instability during walking occurs in the mediolateral direction and thus lateral instability is a significant risk factor for falls. The current study uses one-month of beam walking to challenge the dynamic mediolateral stability of older adults in an attempt to improve balance and reduce falls risk.</div></div><div><h3>Material and methods</h3><div>25 community dwelling older adults over 70 years of age (Mean = 83.5 yrs.) completed a fear of falling questionnaire, the Activities-specific Balance Confidence (ABC) scale, the Dynamic Gait Index (DGI), and normal and fast walking trials. Participants then walked along a series of wooden beams of decreasing widths. Following pretest measurements participants practiced walking on the beams twice a week for 4 weeks. Assessments were conducted at the end of practice (posttest) and one week later (retention test).</div></div><div><h3>Results</h3><div>At the pretest 83 % of the participants reported they were somewhat afraid of falling while at the retention test 37 % were somewhat afraid of falling. ABC scores improved from the pretest (M = 61 %) to the retention test (M = 90 %). The DGI also improved significantly as a result of the beam-walking. Gait analysis revealed that stride length and gait velocity increased significantly following training while stride length and stride width variability decreased.</div></div><div><h3>Conclusion</h3><div>Beam training appears to be a simple intervention that can improve dynamic mediolateral stability consequently reducing the falls risk of older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112814"},"PeriodicalIF":3.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter life- and health-span, disturbed insulin-like growth factor signalling in cannabinoid receptor type-1 knockout mice","authors":"A. Bilkei-Gorzo","doi":"10.1016/j.exger.2025.112810","DOIUrl":"10.1016/j.exger.2025.112810","url":null,"abstract":"<div><div>Cannabinoid receptor type-1 (Cnr1) signalling declines with age, which may contribute to the ageing process, as Cnr1 activity influences several hallmarks of ageing. Indeed, previous studies have shown that mice with a genetic deletion of Cnr1 (Cnr1^−/−) exhibit an early onset of brain ageing. However, it is not yet clear whether Cnr1 activity influences life span and the pace of bodily ageing. Thus, we asked whether the life- and health-span of Cnr1^−/− mice differs from their wild-type controls and whether their insulin-like growth factor 1 (IGF-1) and gonadotropin-releasing hormone (GnRH) signalling is affected.</div><div>Comparison of survival curves revealed that the median survival time of Cnr1^−/− mice was lower than that of Cnr1^+/+ wild-type or Cnr1^+/− mice, similarly in both sexes. Frailty developed earlier and was more intense in both knockout and heterozygous animals than in their wild-type siblings, in males and females alike. Cnr1^−/− mice had reduced hypothalamic expression of GHRH and lower IGF-1 plasma levels – thus reduced IGF-1 signalling. Furthermore, we observed a reduced GnRH production and lower expression of elements of IGF-1 receptor signalling in the hypothalamus of knockout animals.</div><div>The present study demonstrates that reduced CB1 receptor activity accelerates bodily ageing by reducing GnRH production. Furthermore, the lower IGF-1 signalling did not compensate for the early ageing phenotype of the knockout mice.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112810"},"PeriodicalIF":3.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of personality on wearable activity trackers use among Chinese patients over 50 with type 2 diabetes mellitus: A technology acceptance model perspective","authors":"Zeming Li ,&nbsp;Ping Chen ,&nbsp;Xinying Sun","doi":"10.1016/j.exger.2025.112813","DOIUrl":"10.1016/j.exger.2025.112813","url":null,"abstract":"<div><h3>Objective</h3><div>This study uses the technology acceptance model (TAM) as the theoretical framework to explore the predicting factors of intention to adopt wearable activity trackers and the actual wearing behavior among Chinese type 2 diabetes mellitus (T2DM) patients over 50 with different personality traits.</div></div><div><h3>Methods</h3><div>The wearable activity tracker (WAT) was freely distributed to T2DM patients recruited from 22 community health service stations affiliating to four community health service centers in Beijing. A questionnaire survey was conducted to examine predicting factors of adoption intention after a week's try-on. Actual wearing behavior for 30-day was obtained from the exclusive cloud. Latent profile analysis was used to explore personality portraits. Structural equation modeling (SEM) was used to analyze the data.</div></div><div><h3>Results</h3><div>A total of 668 patients (age over 50) with T2DM were included in the analysis. According to the latent profile analysis, the T2DM patients in this study could be classified into four personality profiles: Negative, Anxious, Introverted-Stable (IS), and Active-Responsible (AR). The results of SEM indicated that perceived ease of use (PEOU, β = 0.37, <em>P</em> &lt; 0.01), perceived usefulness (PU, β = 0.31, <em>P</em> &lt; 0.01), social image (SI,β = 0.11, P &lt; 0.01), and privacy concerns (PC, β = −0.50, P &lt; 0.01) directly influenced behavioral intention. Neuroticism positively influenced SI (β = 0.18, <em>P</em> &lt; 0.01). Conscientiousness and openness positively impacted PEOU (β = 0.20, <em>P</em> &lt; 0.01; β = 0.09, <em>P</em> &lt; 0.05). Agreeableness negatively influenced PC (β = −0.17, <em>P</em> &lt; 0.01). Openness and extraversion positively impacted individual innovation(β = 0.15, <em>P</em> &lt; 0.01; β = 0.17, P &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Adoption intentions of WAT was the main factor influencing the actual wearing behavior of older patients with T2DM. PEOU, PU, and SI were the main facilitators of adoption intention, while PC was the main barrier. Different personality traits have their particular path of influence on WAT adoption intentions. It is recommended that future interventions with new devices or technologies for older patients with T2DM be carried out according to the preferences and needs of patients with different personality traits, such as product ease of use, innovativeness, and aesthetics, to promote patients' intention and actual use behaviors.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112813"},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics analysis based on microarray data reveals molecular crosstalk and immune relationship between sarcopenia and atherosclerosis","authors":"Jinghong Yang ,&nbsp;Jun Zhong ,&nbsp;Yimin Du ,&nbsp;Jialin Liu ,&nbsp;Zhong Li ,&nbsp;Yanshi Liu","doi":"10.1016/j.exger.2025.112811","DOIUrl":"10.1016/j.exger.2025.112811","url":null,"abstract":"<div><h3>Background</h3><div>Several global studies have investigated the association between sarcopenia and atherosclerosis. However, the potential common pathogenesis, molecular mechanisms, and their relationship remain elusive. Through bioinformatic analysis, we aim to identify potential biomarkers and therapeutic targets for sarcopenia and atherosclerosis, providing a theoretical foundation for future research.</div></div><div><h3>Methods</h3><div>We screened microarray data from the Gene Expression Omnibus to explore the relationship between atherosclerosis and sarcopenia. We employed multiple statistical methods and bioinformatics tools to identify shared differentially expressed genes (DEGs). Subsequently, we conducted functional enrichment analysis, protein-protein interaction analysis, and TF-gene interaction network analysis, as well as TF-miRNA coregulatory network analysis. Drug compounds were predicted using the Drug Signatures database based on the common DEGs. Immune infiltration analysis was conducted on sarcopenia and atherosclerosis datasets. Finally, ROC curves were plotted to verify the reliability of our results using external databases.</div></div><div><h3>Result</h3><div>We identified 11 upregulated and 17 downregulated DEGs that were enriched in microglial cell activation, plasma membrane raft, and phosphatidylinositol−3,4−bisphosphate binding. PPI network analysis identified 6 hub genes: ADA, AIM2, CSF1R, C1QA, NCF1, and ITGAM. Notably, Isotretinoin HL60 UP is considered to be the best candidate drug for the treatment of sarcopenia and atherosclerosis, and some immune cells associated with atherosclerosis and sarcopenia were identified.</div></div><div><h3>Conclusion</h3><div>Through bioinformatic analysis, we identified potential biomarkers and therapeutic targets for atherosclerosis and sarcopenia, providing a theoretical basis for future studies.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112811"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans","authors":"Hanghang Gan ,&nbsp;Yu Yan ,&nbsp;Shanshan Jia ,&nbsp;Yingqiang Guo ,&nbsp;Gonggong Lu","doi":"10.1016/j.exger.2025.112805","DOIUrl":"10.1016/j.exger.2025.112805","url":null,"abstract":"<div><h3>Object</h3><div>To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weighted multivariate cox regression analyses were performed to assess the association between different combinations of calorie intake and exercise and mortality. Interaction effects were evaluated using the relative excess risk of interaction (RERI), attributable proportion of interaction (API), and synergy index (SI). Subgroup and sensitivity analyses were also conducted.</div></div><div><h3>Results</h3><div>A total of 21,618 participants (51 % female) were included, with 1957 all-cause deaths, 568 cardiovascular deaths, and 508 cancer deaths over a median follow-up of 6.75 years. Both higher- and low-calorie diet were associated with reduced all-cause mortality as long as the participants engaged in adequate exercise, with greater benefits in the former group (Higher-calorie diet: Hazard ratio (HR) [95%CI] 0.59 [0.48, 0.71]; low-calorie diet: 0.69 [0.56, 0.84]; both <em>P</em> &lt; 0.001). Only higher-calorie diet with adequate exercise was associated with reduced cardiovascular mortality (HR 0.64 [0.43, 0.94], <em>P</em> = 0.022, P for trend = 0.085). No significant association about cancer mortality was observed (<em>P</em> &gt; 0.05). There was no additive interaction between low-calorie diet and adequate exercise in reducing mortality (all P &gt; 0.05). Subgroup and sensitivity analyses remained stable.</div></div><div><h3>Conclusion</h3><div>Adequate exercise with either higher- or low-calorie diet was associated with reduced all-cause mortality, with greater benefits in the former group. Moreover, only the former was associated with a reduction in cardiovascular mortality.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112805"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the acutely presenting older patients tool in a real world setting: results from a large clinical hospital in the Netherlands","authors":"J.C. van Groen ,&nbsp;A.M. van Alphen ,&nbsp;S.P. Mooijaart ,&nbsp;C. van Noord ,&nbsp;R. Ruiter","doi":"10.1016/j.exger.2025.112804","DOIUrl":"10.1016/j.exger.2025.112804","url":null,"abstract":"<div><h3>Introduction</h3><div>The number of older patients visiting the emergency department (ED) is increasing. The Acutely Presenting Older Patients (APOP) screener has been developed to identify older patients at highest risk of mortality or functional decline after the hospital visit. In this study we aim to assess association between the APOP score and mortality for older patients presenting in the ED at the Maasstad hospital using real world data.</div></div><div><h3>Methods</h3><div>Within this retrospective cohort study, all patients aged 70 years and older, who visited the ED of the Maasstad Hospital in 2021 were included. The use of the APOP screener is standard practice at the ED of the Maasstad Hospital. Patients who were triaged red with the Manchester Triage System were excluded from the analyses.</div></div><div><h3>Results</h3><div>6136 patients of 70 years and older were included at the ED of the Maasstad Hospital. 70.9 % of these patients had a filled APOP screener. Of those patients, 663 died (15.2 %). Mortality rate was lower in patients with a negative APOP screener than in patients with a positive APOP screener (9.7 % vs 25.6 %), with an odds ratio of 2.08 (CI95% 1.88–2.30).</div></div><div><h3>Conclusion</h3><div>This study shows that the APOP screener, when used in the real word, has a fairly high association with three month mortality, even when adjusting for other variables that could indicate frailty. Furthermore the fill-in rate, in the real world, is high which shows that its implementation in a large teaching hospital is feasible.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112804"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between youth obesity and metabolic syndrome among middle-aged and elderly adults in the United States","authors":"Gang Cheng ,&nbsp;Ying Zhou ,&nbsp;Yan Wang,&nbsp;Chunguang Wang,&nbsp;Jianghong Xu","doi":"10.1016/j.exger.2025.112806","DOIUrl":"10.1016/j.exger.2025.112806","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to observe the relationship between youth obesity and metabolic syndrome (MetS) among middle-aged and elderly adults in the United States.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted on United States adults aged ≥50 years. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 cycles. The levels of height and weight at aged 25 years were obtained. Body mass index (BMI) at aged 25 years (BMI₂₅) was calculated. Healthy weight, overweight and obesity at aged 25 years (healthy weight₂₅, overweight₂₅ and obesity₂₅) were defined as BMI₂₅ 18.5 to &lt;25 kg/m², 25 to &lt;30 kg/m² and 30 kg/m² or greater. MetS was defined According to the National Cholesterol Education Program's Adult Treatment Panel III report (ATP III).</div></div><div><h3>Results</h3><div>The prevalences of MetS were 48.7 %, 63.5 %, and 71.4 % in adults with healthy weight₂₅, overweight₂₅, and obesity₂₅ group. After control for confounding factors, the prevalences of MetS in overweight₂₅ group and obesity₂₅ group were 2.147 (95%CI: 1.892–2.436, <em>P</em> &lt; 0.001) times and 2.878 (95%CI: 2.304–3.597, <em>P</em> &lt; 0.001) times than that in healthy weight₂₅ group. After further adjusted for BMI at the time of survey, the prevalences of MetS in adults with overweight₂₅ group and obesity₂₅ group were 1.193 (95%CI:1.035–1.375，<em>P</em> = 0.015) times and 1.222 (95%CI:0.959–1.557，<em>P</em> = 0.105) times than adults with healthy weight₂₅ group.</div></div><div><h3>Conclusion</h3><div>The present study demonstrates that youth obesity was closely associated with an increased risk of MetS among middle-aged and elderly adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112806"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of chronic knee pain and age on conditioned pain modulation and motor unit control","authors":"Emily J. Parsowith ,&nbsp;Emma Herring ,&nbsp;Brandon Cohen ,&nbsp;Kevan S. Knowles ,&nbsp;Ethan C. Hill ,&nbsp;Meredith Chaput ,&nbsp;Abigail W. Anderson ,&nbsp;Matt S. Stock","doi":"10.1016/j.exger.2025.112803","DOIUrl":"10.1016/j.exger.2025.112803","url":null,"abstract":"<div><h3>Background</h3><div>Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of the underlying mechanisms hinders the development of effective treatments.</div></div><div><h3>Purpose</h3><div>This study integrated assessments of Conditioned Pain Modulation (CPM) and motor unit control to elucidate the role of pain sensitization and neuromuscular impairments specific to chronic knee pain.</div></div><div><h3>Methods</h3><div>Seventy-five participants were divided into three groups: young adults (n = 25), older adults without pain (n = 30), and older adults with chronic pain (n = 20). CPM efficiency was evaluated using heat and pressure test stimuli alongside a cold-water bath conditioning stimulus. Motor unit assessments involved isometric contractions of the dominant/painful quadriceps at 50 % of maximal torque, with surface electromyographic signals recorded from the vastus lateralis.</div></div><div><h3>Results</h3><div>Independent of chronic knee pain, older adults demonstrated more efficient heat-CPM than young adults (<em>p</em> = 0.014, η_p² = 0.080). The slope of the mean firing rate versus recruitment threshold relationship indicated that older adults showed greater firing rates for high threshold motor units, independent chronic knee pain (<em>p</em> = 0.010, ηp² = 0.136). The y-intercept of this relationship was greater in younger versus chronic-pain older adults (<em>p</em> = 0.024, ηp² = 0.111).</div></div><div><h3>Conclusion</h3><div>Contrary to our hypothesis, older adults displayed more efficient heat-CPM, independent of chronic pain. Similarly, motor unit control was mostly influenced by age but not chronic knee pain. These findings suggest that age-related changes in pain modulation and motor unit behavior may play a greater role in neuromuscular function than the presence of chronic pain itself.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112803"},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic oxidative stress associates with delirium in a geriatric population with hip fracture","authors":"Monika Trzpis ,&nbsp;Maria Zernova ,&nbsp;Karin M. Vermeulen ,&nbsp;Marian L.C. Bulthuis ,&nbsp;Marjan Reinders-Luinge ,&nbsp;Harry van Goor ,&nbsp;Barbara C. van Munster ,&nbsp;Arno R. Bourgonje","doi":"10.1016/j.exger.2025.112801","DOIUrl":"10.1016/j.exger.2025.112801","url":null,"abstract":"<div><h3>Background</h3><div>Oxidative stress ensues in patients undergoing surgery for hip fracture and has been implicated in the pathophysiology of delirium. Circulating free thiols (R-SH, sulfhydryl groups) serve as biomarker of systemic oxidative stress since they are rapidly oxidized by reactive species, acting as potent antioxidants. We aimed to investigate the relationship between delirium and systemic oxidative stress in older patients hospitalized with hip fracture.</div></div><div><h3>Methods</h3><div>Patients aged 65 years or more, acutely admitted due to hip fracture, were included between 2005 and 2008. Delirium was diagnosed according to the DSM-IV criteria for delirium. Free thiols were determined in plasma samples that had been collected longitudinally during hospitalization for previous clinical trial, using colorimetric detection. Albumin-adjusted plasma free thiol concentrations were both cross-sectionally and longitudinally evaluated in relation to delirium.</div></div><div><h3>Results</h3><div>In total 813 plasma samples from 336 patients were analysed. Delirium was experienced by 110 (33 %) patients. Mean albumin-adjusted free thiols of patients who experienced delirium (7.3 ± SD 1.4 μM/g) was lower than that of non-delirious patients (7.5 ± SD 1.3 μM/g) (<em>P</em> = 0.050). Multivariable logistic regression analysis, adjusted for age, preexisting cognitive impairment, institutionalization, time to surgery, and complications, indicated that delirium was significantly inversely associated with albumin-adjusted free thiol concentrations (OR = 0.8, 95%CI 0.75–0.96). The significant association between delirium and albumin-adjusted free thiols tested in all the samples was also shown by linear mixed model analysis after adjusting for confounders (β = −0.292; 95%CI 0.04–0.55).</div></div><div><h3>Conclusions</h3><div>Reduced concentrations of free thiols, reflecting systemic oxidative stress, are associated with delirium onset among patients with hip fracture.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112801"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}