Experimental gerontology最新文献

{"title":"Construction of a novel online calculator for prediction of osteoporosis risk in Chinese type 2 diabetes patients","authors":"Xing Yu ,&nbsp;Wenchi Liu ,&nbsp;Xiaojun Chen ,&nbsp;Yicheng Wang ,&nbsp;Huibin Tang ,&nbsp;Yunyun Su ,&nbsp;Liangdi Xie ,&nbsp;Li Luo","doi":"10.1016/j.exger.2025.112819","DOIUrl":"10.1016/j.exger.2025.112819","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes (T2D) has been established as an independent risk factor for osteoporosis, often resulting in a poor prognosis. Thus, it is crucial for clinicians to diagnose osteoporosis in diabetic patients. This study aimed to develop a prediction model for osteoporosis in people with T2D from China.</div></div><div><h3>Methods</h3><div>A clinical analysis was retrospectively carried out using our hospital database for patients with definite T2D diagnosed between January 1, 2012, and December 31, 2020. All patients were randomly divided into a training set (70 %) and a test set (30 %). Then, univariate and multivariate logistic regression analyses were used to screen independent risk factors for osteoporosis. Machine learning(ML) models were developed to predict osteoporosis risk using different methods such as logistic regression (LR), naive Bayes (NB), neural network (NNET), support vector machine (SVM), gradient boosting machine (GBM), and k-nearest neighbor (KNN). In addition, Shapley additivity explanations (SHAP) were employed to determine the significance of selected features and interpret the ML models.</div></div><div><h3>Results</h3><div>A total of 2029 patients were enrolled in the study, of which 457 suffered from osteoporosis. Based on the analysis, five characteristic variables were selected to construct the predictive model for osteoporosis in diabetics, comprising gender, age, BMI, heart rate, and alkaline phosphatase. The GBM model revealed an AUC of 0.79 in the test set and 0.89 in the external validation set. Furthermore, the calibration curves, decision curve analysis, and precision-recall curves highlighted the satisfactory clinical applicability of the GBM model. According to this model, an online calculator was built for clinicians to diagnose diabetes-related osteoporosis patients.</div></div><div><h3>Conclusion</h3><div>Age, sex, BMI, heart rate, and ALP are significantly associated with osteoporosis in people with T2D. The screening model provides an accurate, user-friendly, and low-cost tool for the early diagnosis of osteoporosis in people with T2D from China.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112819"},"PeriodicalIF":3.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of the Clinical pHysical rEsilience assEssment Scale (CHEES) in community-dwelling older adults","authors":"Yiwen Xing ,&nbsp;Pan Liu ,&nbsp;Wenhua Yu ,&nbsp;Yiwei Zhao ,&nbsp;Zhibin Wang ,&nbsp;Yue Wu ,&nbsp;Xue Gao ,&nbsp;Yu Wang ,&nbsp;Yansu Guo ,&nbsp;Yumin Wang ,&nbsp;Yi Tang ,&nbsp;Lina Ma","doi":"10.1016/j.exger.2025.112818","DOIUrl":"10.1016/j.exger.2025.112818","url":null,"abstract":"<div><h3>Background</h3><div>Physical resilience is closely related to healthy aging and refers to the ability of an individual to recover or maintain function after a stressor. However, tools for assessing physical resilience among community-dwelling older adults in China are lacking. We previously developed a 14-item Clinical pHysical rEsilience assEssment Scale (CHEES) in Chinese older adults.</div></div><div><h3>Objective</h3><div>To determine the reliability and validity of the CHEES among community-dwelling older adults.</div></div><div><h3>Methods</h3><div>A total of 1934 older adults from the Beijing community were included. The acceptability of the scale was evaluated by scale acceptance rate, scale qualification rate, and scale completion time. The reliability of the scale was evaluated from the aspects of internal consistency, split-half, and test-retest reliability. The validity of the scale was evaluated in terms of content, construct, and criterion validity.</div></div><div><h3>Results</h3><div>The average age of the 1934 older adults was 69.73 ± 5.95 years, of whom 1219 were female (63.03 %). The CHEES scale acceptance and qualification rate were both 100 %, and the scale completion time was 2–3 min. The Cronbach's alpha, Spearman–Brown, and Guttman's split-half coefficients for the total scale were 0.733, 0.508, and 0.507, respectively. The Cronbach's alpha, Spearman–Brown, and Guttman's split-half coefficients were 0.567, 0.252, and 0.195 for the intrinsic capacity dimension; 0.768, 0.826, and 0.759 for the adapt to change dimension; and 0.646, 0.554, and 0.554 for the external support dimension, respectively. In the test-retest reliability analysis, the intraclass correlation coefficient for the total scores of the two assessments was 0.915. Further exploratory factor analysis showed that the cumulative variance contribution rate of the common factor was 59.91 %, with factor loadings for each item ranging from 0.472 to 0.858. The Spearman correlation coefficient between CHEES and the Barthel index was 0.110.</div></div><div><h3>Conclusions</h3><div>The CHEES exhibits good reliability and validity; therefore, it can be used as a reliable tool for evaluating physical resilience of older adults in community settings.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112818"},"PeriodicalIF":3.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization study of lipid metabolites reveals causal associations with age-related macular degeneration","authors":"Miao Shui ,&nbsp;Guoke Yang ,&nbsp;Jiang Jiang ,&nbsp;Sibo Wang ,&nbsp;Rongfeng Liao","doi":"10.1016/j.exger.2025.112817","DOIUrl":"10.1016/j.exger.2025.112817","url":null,"abstract":"<div><h3>Background</h3><div>Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly, affecting approximately 8.7 % of individuals over 55 years old. Increasing evidence suggests that lipid metabolism plays a significant role in AMD pathogenesis, yet the causal relationships remain unclear. This study aims to elucidate the causal relationship between lipid metabolites and AMD using Mendelian randomization (MR) methodology.</div></div><div><h3>Methods</h3><div>A two-sample MR analysis was conducted to explore the associations between specific lipid metabolites (such as bile acids, fatty acids, sphingolipids, and steroid hormones) and the incidence of AMD, as well as the potential causal effect of AMD on these lipid metabolites. Genetic variants significantly associated with these lipid metabolites were selected as instrumental variables (IVs). Data for AMD and lipid metabolites were sourced from the IEU GWAS database, covering over 209,000 cases and &gt;16 million single nucleotide polymorphisms (SNPs). The MR analysis employed inverse-variance weighted (IVW), MR-Egger regression, and weighted median methods to estimate causal relationships and address potential pleiotropy and heterogeneity.</div></div><div><h3>Results</h3><div>IVW analysis revealed significant associations between several lipid metabolites and AMD. Specifically, higher levels of laurate were found to increase the risk of AMD by 3.532 times (OR = 3.532, 95%CI 1.498–8.328, <em>P</em> &lt; 0.010). In contrast, dehydroepiandrosterone sulfate (DHEA-S) (OR = 0.551, 95%CI 0.311–0.977, <em>P</em> = 0.042) and palmitoyl sphingomyelin (OR = 0.213, 95%CI 0.053–0.863, <em>P</em> = 0.030) were protective, with DHEA-S and palmitoyl sphingomyelin levels reducing the risk of AMD by 44.9 % and 78.7 %, respectively. Sensitivity analyses using MR-Egger and weighted median methods supported these findings, highlighting consistent trends across different analytical approaches.</div></div><div><h3>Conclusion</h3><div>By clarifying these causal relationships, this research aims to provide insights that could inform the development of therapeutic strategies targeting lipid metabolism, ultimately improving outcomes for individuals at risk of AMD.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112817"},"PeriodicalIF":3.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task difficulty modulates motor learning benefits of balance exercises in community-dwelling older adults","authors":"Kazunori Akizuki ,&nbsp;Kosuke Takeuchi ,&nbsp;Kazuto Yamaguchi ,&nbsp;Ryohei Yamamoto ,&nbsp;Wataru Nakano ,&nbsp;Jun Yabuki","doi":"10.1016/j.exger.2025.112816","DOIUrl":"10.1016/j.exger.2025.112816","url":null,"abstract":"<div><h3>Purpose</h3><div>Balance disorders are a major modifiable risk factor for falls, and balance exercises reduce fall rates. However, the effectiveness of balance exercises may depend on the relationship between the task difficulty and individual skill levels. This study aimed to explore the impact of task difficulty on the motor learning benefits of balance exercises.</div></div><div><h3>Methods</h3><div>A sex-stratified, randomized, and non-blinded study was conducted among 40 community-dwelling older adults assigned to either a low- or high-difficulty balance exercise group. The task difficulty was manipulated by altering the support component affixed to an unstable board. Balance performance was measured using a stability index, and functional task difficulty was assessed using the National Aeronautics and Space Administration Task Load Index (NASA-TLX). The experiment included a pre-test, practice trials, and post-test conducted 24 h later. Statistical analyses included analysis of variance and regression analyses to examine the impact of task difficulty on motor learning and the relationship between motor learning benefits and task difficulty.</div></div><div><h3>Results</h3><div>While both groups showed improved balance performance with practice, the low-difficulty group demonstrated greater motor learning benefits at the 24-h post-test (<em>p</em> &lt; 0.001). Regression analysis showed a curvilinear relationship between the performance dimension score of the NASA-TLX and motor learning benefits (y = -0.017x² + 1.843x - 26.711, adjusted <em>R</em>^<em>2</em> = 0.380, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>In balance exercises for community-dwelling older adults, task difficulty significantly influences exercise intervention effectiveness. Our findings contribute to the development of personalized fall prevention programs that adjust task difficulty according to individual skill levels.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112816"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beam walking increases gait velocity and reduces falls risk in older adults","authors":"Ben Sidaway","doi":"10.1016/j.exger.2025.112814","DOIUrl":"10.1016/j.exger.2025.112814","url":null,"abstract":"<div><h3>Introduction</h3><div>A third of community-dwelling older adults will fall at least once per year, often during walking. In such individuals, the greatest postural instability during walking occurs in the mediolateral direction and thus lateral instability is a significant risk factor for falls. The current study uses one-month of beam walking to challenge the dynamic mediolateral stability of older adults in an attempt to improve balance and reduce falls risk.</div></div><div><h3>Material and methods</h3><div>25 community dwelling older adults over 70 years of age (Mean = 83.5 yrs.) completed a fear of falling questionnaire, the Activities-specific Balance Confidence (ABC) scale, the Dynamic Gait Index (DGI), and normal and fast walking trials. Participants then walked along a series of wooden beams of decreasing widths. Following pretest measurements participants practiced walking on the beams twice a week for 4 weeks. Assessments were conducted at the end of practice (posttest) and one week later (retention test).</div></div><div><h3>Results</h3><div>At the pretest 83 % of the participants reported they were somewhat afraid of falling while at the retention test 37 % were somewhat afraid of falling. ABC scores improved from the pretest (M = 61 %) to the retention test (M = 90 %). The DGI also improved significantly as a result of the beam-walking. Gait analysis revealed that stride length and gait velocity increased significantly following training while stride length and stride width variability decreased.</div></div><div><h3>Conclusion</h3><div>Beam training appears to be a simple intervention that can improve dynamic mediolateral stability consequently reducing the falls risk of older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112814"},"PeriodicalIF":3.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter life- and health-span, disturbed insulin-like growth factor signalling in cannabinoid receptor type-1 knockout mice","authors":"A. Bilkei-Gorzo","doi":"10.1016/j.exger.2025.112810","DOIUrl":"10.1016/j.exger.2025.112810","url":null,"abstract":"<div><div>Cannabinoid receptor type-1 (Cnr1) signalling declines with age, which may contribute to the ageing process, as Cnr1 activity influences several hallmarks of ageing. Indeed, previous studies have shown that mice with a genetic deletion of Cnr1 (Cnr1^−/−) exhibit an early onset of brain ageing. However, it is not yet clear whether Cnr1 activity influences life span and the pace of bodily ageing. Thus, we asked whether the life- and health-span of Cnr1^−/− mice differs from their wild-type controls and whether their insulin-like growth factor 1 (IGF-1) and gonadotropin-releasing hormone (GnRH) signalling is affected.</div><div>Comparison of survival curves revealed that the median survival time of Cnr1^−/− mice was lower than that of Cnr1^+/+ wild-type or Cnr1^+/− mice, similarly in both sexes. Frailty developed earlier and was more intense in both knockout and heterozygous animals than in their wild-type siblings, in males and females alike. Cnr1^−/− mice had reduced hypothalamic expression of GHRH and lower IGF-1 plasma levels – thus reduced IGF-1 signalling. Furthermore, we observed a reduced GnRH production and lower expression of elements of IGF-1 receptor signalling in the hypothalamus of knockout animals.</div><div>The present study demonstrates that reduced CB1 receptor activity accelerates bodily ageing by reducing GnRH production. Furthermore, the lower IGF-1 signalling did not compensate for the early ageing phenotype of the knockout mice.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112810"},"PeriodicalIF":3.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of personality on wearable activity trackers use among Chinese patients over 50 with type 2 diabetes mellitus: A technology acceptance model perspective","authors":"Zeming Li ,&nbsp;Ping Chen ,&nbsp;Xinying Sun","doi":"10.1016/j.exger.2025.112813","DOIUrl":"10.1016/j.exger.2025.112813","url":null,"abstract":"<div><h3>Objective</h3><div>This study uses the technology acceptance model (TAM) as the theoretical framework to explore the predicting factors of intention to adopt wearable activity trackers and the actual wearing behavior among Chinese type 2 diabetes mellitus (T2DM) patients over 50 with different personality traits.</div></div><div><h3>Methods</h3><div>The wearable activity tracker (WAT) was freely distributed to T2DM patients recruited from 22 community health service stations affiliating to four community health service centers in Beijing. A questionnaire survey was conducted to examine predicting factors of adoption intention after a week's try-on. Actual wearing behavior for 30-day was obtained from the exclusive cloud. Latent profile analysis was used to explore personality portraits. Structural equation modeling (SEM) was used to analyze the data.</div></div><div><h3>Results</h3><div>A total of 668 patients (age over 50) with T2DM were included in the analysis. According to the latent profile analysis, the T2DM patients in this study could be classified into four personality profiles: Negative, Anxious, Introverted-Stable (IS), and Active-Responsible (AR). The results of SEM indicated that perceived ease of use (PEOU, β = 0.37, <em>P</em> &lt; 0.01), perceived usefulness (PU, β = 0.31, <em>P</em> &lt; 0.01), social image (SI,β = 0.11, P &lt; 0.01), and privacy concerns (PC, β = −0.50, P &lt; 0.01) directly influenced behavioral intention. Neuroticism positively influenced SI (β = 0.18, <em>P</em> &lt; 0.01). Conscientiousness and openness positively impacted PEOU (β = 0.20, <em>P</em> &lt; 0.01; β = 0.09, <em>P</em> &lt; 0.05). Agreeableness negatively influenced PC (β = −0.17, <em>P</em> &lt; 0.01). Openness and extraversion positively impacted individual innovation(β = 0.15, <em>P</em> &lt; 0.01; β = 0.17, P &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Adoption intentions of WAT was the main factor influencing the actual wearing behavior of older patients with T2DM. PEOU, PU, and SI were the main facilitators of adoption intention, while PC was the main barrier. Different personality traits have their particular path of influence on WAT adoption intentions. It is recommended that future interventions with new devices or technologies for older patients with T2DM be carried out according to the preferences and needs of patients with different personality traits, such as product ease of use, innovativeness, and aesthetics, to promote patients' intention and actual use behaviors.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112813"},"PeriodicalIF":3.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics analysis based on microarray data reveals molecular crosstalk and immune relationship between sarcopenia and atherosclerosis","authors":"Jinghong Yang ,&nbsp;Jun Zhong ,&nbsp;Yimin Du ,&nbsp;Jialin Liu ,&nbsp;Zhong Li ,&nbsp;Yanshi Liu","doi":"10.1016/j.exger.2025.112811","DOIUrl":"10.1016/j.exger.2025.112811","url":null,"abstract":"<div><h3>Background</h3><div>Several global studies have investigated the association between sarcopenia and atherosclerosis. However, the potential common pathogenesis, molecular mechanisms, and their relationship remain elusive. Through bioinformatic analysis, we aim to identify potential biomarkers and therapeutic targets for sarcopenia and atherosclerosis, providing a theoretical foundation for future research.</div></div><div><h3>Methods</h3><div>We screened microarray data from the Gene Expression Omnibus to explore the relationship between atherosclerosis and sarcopenia. We employed multiple statistical methods and bioinformatics tools to identify shared differentially expressed genes (DEGs). Subsequently, we conducted functional enrichment analysis, protein-protein interaction analysis, and TF-gene interaction network analysis, as well as TF-miRNA coregulatory network analysis. Drug compounds were predicted using the Drug Signatures database based on the common DEGs. Immune infiltration analysis was conducted on sarcopenia and atherosclerosis datasets. Finally, ROC curves were plotted to verify the reliability of our results using external databases.</div></div><div><h3>Result</h3><div>We identified 11 upregulated and 17 downregulated DEGs that were enriched in microglial cell activation, plasma membrane raft, and phosphatidylinositol−3,4−bisphosphate binding. PPI network analysis identified 6 hub genes: ADA, AIM2, CSF1R, C1QA, NCF1, and ITGAM. Notably, Isotretinoin HL60 UP is considered to be the best candidate drug for the treatment of sarcopenia and atherosclerosis, and some immune cells associated with atherosclerosis and sarcopenia were identified.</div></div><div><h3>Conclusion</h3><div>Through bioinformatic analysis, we identified potential biomarkers and therapeutic targets for atherosclerosis and sarcopenia, providing a theoretical basis for future studies.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112811"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher calorie intake with adequate exercise is associated with reduced mortality compared with low-calorie diet with equivalent exercise: An observational study from NHANES based on the 2020–2025 Dietary Guidelines for Americans","authors":"Hanghang Gan ,&nbsp;Yu Yan ,&nbsp;Shanshan Jia ,&nbsp;Yingqiang Guo ,&nbsp;Gonggong Lu","doi":"10.1016/j.exger.2025.112805","DOIUrl":"10.1016/j.exger.2025.112805","url":null,"abstract":"<div><h3>Object</h3><div>To explore the effects of different combinations of calorie intake and exercise on all-cause, cardiovascular and cancer mortality.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Weighted multivariate cox regression analyses were performed to assess the association between different combinations of calorie intake and exercise and mortality. Interaction effects were evaluated using the relative excess risk of interaction (RERI), attributable proportion of interaction (API), and synergy index (SI). Subgroup and sensitivity analyses were also conducted.</div></div><div><h3>Results</h3><div>A total of 21,618 participants (51 % female) were included, with 1957 all-cause deaths, 568 cardiovascular deaths, and 508 cancer deaths over a median follow-up of 6.75 years. Both higher- and low-calorie diet were associated with reduced all-cause mortality as long as the participants engaged in adequate exercise, with greater benefits in the former group (Higher-calorie diet: Hazard ratio (HR) [95%CI] 0.59 [0.48, 0.71]; low-calorie diet: 0.69 [0.56, 0.84]; both <em>P</em> &lt; 0.001). Only higher-calorie diet with adequate exercise was associated with reduced cardiovascular mortality (HR 0.64 [0.43, 0.94], <em>P</em> = 0.022, P for trend = 0.085). No significant association about cancer mortality was observed (<em>P</em> &gt; 0.05). There was no additive interaction between low-calorie diet and adequate exercise in reducing mortality (all P &gt; 0.05). Subgroup and sensitivity analyses remained stable.</div></div><div><h3>Conclusion</h3><div>Adequate exercise with either higher- or low-calorie diet was associated with reduced all-cause mortality, with greater benefits in the former group. Moreover, only the former was associated with a reduction in cardiovascular mortality.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112805"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the acutely presenting older patients tool in a real world setting: results from a large clinical hospital in the Netherlands","authors":"J.C. van Groen ,&nbsp;A.M. van Alphen ,&nbsp;S.P. Mooijaart ,&nbsp;C. van Noord ,&nbsp;R. Ruiter","doi":"10.1016/j.exger.2025.112804","DOIUrl":"10.1016/j.exger.2025.112804","url":null,"abstract":"<div><h3>Introduction</h3><div>The number of older patients visiting the emergency department (ED) is increasing. The Acutely Presenting Older Patients (APOP) screener has been developed to identify older patients at highest risk of mortality or functional decline after the hospital visit. In this study we aim to assess association between the APOP score and mortality for older patients presenting in the ED at the Maasstad hospital using real world data.</div></div><div><h3>Methods</h3><div>Within this retrospective cohort study, all patients aged 70 years and older, who visited the ED of the Maasstad Hospital in 2021 were included. The use of the APOP screener is standard practice at the ED of the Maasstad Hospital. Patients who were triaged red with the Manchester Triage System were excluded from the analyses.</div></div><div><h3>Results</h3><div>6136 patients of 70 years and older were included at the ED of the Maasstad Hospital. 70.9 % of these patients had a filled APOP screener. Of those patients, 663 died (15.2 %). Mortality rate was lower in patients with a negative APOP screener than in patients with a positive APOP screener (9.7 % vs 25.6 %), with an odds ratio of 2.08 (CI95% 1.88–2.30).</div></div><div><h3>Conclusion</h3><div>This study shows that the APOP screener, when used in the real word, has a fairly high association with three month mortality, even when adjusting for other variables that could indicate frailty. Furthermore the fill-in rate, in the real world, is high which shows that its implementation in a large teaching hospital is feasible.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112804"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}