Experimental gerontology最新文献

{"title":"Foresight older adults' quality of life in the aging crisis in Iran: A systematic review and meta-analysis.","authors":"Raheleh Alimoradzadeh, Katayoun Jahangiri, Roya Alimoradzadeh","doi":"10.1016/j.exger.2024.112671","DOIUrl":"https://doi.org/10.1016/j.exger.2024.112671","url":null,"abstract":"<p><strong>Introduction: </strong>To provide foresight for the older adults' quality of life (QOL) in the aging crisis in Iran, this systematic review and meta-analysis study is conducted.</p><p><strong>Methods: </strong>All relevant articles were searched in the English and Persian databases such as Scopus, Web of Science, PubMed, Google Scholar, SID, and Medex regardless of the time range up to December 2023.</p><p><strong>Results: </strong>Out of 348 articles found, 8 articles were included finally. In total, the QOL of 1093 older adults' people with a mean age of 71.55 ± 6.91 years were evaluated. The study showed that the overall average of the QOL of the older adults is 58.5 ± 10.1 The overall average QOL of the older adults at the Iranian community level was 57.6 ± 15.5. The overall average QOL of the older adults in nursing homes are 60.1 ± 29.7.</p><p><strong>Conclusion: </strong>The Iranian older adults have an average QOL and paying attention to the older adults and their needs and designing interventions to improve their health status should be on the agenda of health policymakers.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112671"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents.","authors":"Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Caio Victor Sousa, Thiago Dos Santos Rosa, Ivo Vieira Sousa Neto, Emanuele Marzetti, Octávio Luiz Franco, Samuel da Silva Aguiar","doi":"10.1016/j.exger.2024.112662","DOIUrl":"10.1016/j.exger.2024.112662","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.</p><p><strong>Methods: </strong>The study involved 11 older adults (83.09 ± 8.1 years) residing in a long-term care institution, spanning 42 weeks with assessments at weeks 1, 14-15, 28, and 42. The initial 12 weeks following the first assessment (weeks 2-13) served as a baseline, during which participants maintained their routine activities. A dual-task resistance training protocol was implemented from weeks 16 to 27, followed by a detraining period from weeks 29 to 41. Assessments included clinical characteristics, physical function, cognitive ability, blood samples for biochemical parameters, oxidative stress, and chronic inflammation.</p><p><strong>Results: </strong>Dual-task RT significantly enhanced balance (p = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. It also decreased the completion time for the sit-and-stand test both post-training (p = 0.008) and post-detraining (p = 0.015) relative to baseline. Cognitive ability showed significant improvements (p < 0.05). The CAT/TBARS ratio increased significantly post-training (p < 0.001) and remained elevated post-detraining. Nitric Oxide levels increased post-training (p < 0.05) and stayed higher post-detraining. The IL-10/TNF-α ratio significantly increased post-training (p < 0.05).</p><p><strong>Conclusion: </strong>Dual-task RT performed over 12 weeks improved physical function, cognitive capacity, muscular strength, oxidative stress markers, and chronic inflammation in institutionalized older adults. Furthermore, these benefits were sustained even after a period of detraining.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112662"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for the special issue on \"microbiomes in extremes of aging\".","authors":"Hariom Yadav, Varsha D Badal, Michal M Masternak, Christiaan Leeuwenburgh","doi":"10.1016/j.exger.2024.112663","DOIUrl":"10.1016/j.exger.2024.112663","url":null,"abstract":"<p><p>This special issue of the Journal of Experimental Gerontology explores the dynamic interplay between microbiomes and aging-related conditions. The four selected studies highlight the role of microbiota in Alzheimer's disease, cancer immunotherapy, myocardial infarction and tryptophan metabolism, providing insights into how microbiomes influence health and disease in aging. These studies underscore the potential for microbiome-targeted interventions to mitigate aging-related disorders and improve the quality of life for older adults.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112663"},"PeriodicalIF":3.9,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Vivifrail-B multicomponent exercise program based on society ecosystems theory on physical function in community-dwelling frail older adults: A randomized controlled trial.","authors":"Yue Li, Shasha Li, Xu Weng, Xinyu Yang, Jianyi Bao, Shufang Liao, Yingxue Xi, Xiaofang Song, Guojing Guo","doi":"10.1016/j.exger.2024.112670","DOIUrl":"https://doi.org/10.1016/j.exger.2024.112670","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to explore the short and long-term effects of the Vivifrail-B multicomponent exercise based on society ecosystems theory on physical function in community-dwelling frail older adults.</p><p><strong>Methods: </strong>59 older adults were randomly assigned to the intervention (n = 30) and control (n = 29) groups. The exercise was performed thrice a week for 12 weeks, with one offline group training and two at home training. The Tilburg Frailty Indicator (TFI), the Short Physical Performance Battery (SPPB), Handgrip strength (HGS), the Physical Self-Maintenance Scale (PSMS), and the Instrumental Activities of Daily Living Scale (IADL) were assessed at baseline, 6 weeks, 12 weeks, 18 weeks, and 24 weeks. Exercise compliance assessments and satisfaction surveys were conducted at post intervention. Generalized estimating equations was used to compare outcome measures.</p><p><strong>Results: </strong>At T1 (6-week), SPPB (P = 0.040) and PSMS (P = 0.042) of subjects in the intervention group were statistically different from the control group. At T2 (12-week), T3 (18-week) and T4 (24-week), all variables were significantly improved compared to the control group (all, P < 0.05), except for IADL (P_T2 = 0.181, P_T3 = 0.192, P_T4 = 0.163). The short and long-term effects of the intervention were significant compared to the baseline level. However, the differences in Psychology (P = 0.699) and Society (P = 0.644) before and after the intervention were not significant.</p><p><strong>Conclusion: </strong>Vivifrail-B multicomponent exercise based on society ecosystems theory improved physical function of community-dwelling frail older adults, and the older adults' exercise compliance and satisfaction were high.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112670"},"PeriodicalIF":3.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8.","authors":"Stefano Cacciatore, Riccardo Calvani, Jasmine Mancini, Francesca Ciciarello, Vincenzo Galluzzo, Matteo Tosato, Emanuele Marzetti, Francesco Landi","doi":"10.1016/j.exger.2024.112666","DOIUrl":"10.1016/j.exger.2024.112666","url":null,"abstract":"<p><strong>Background: </strong>Poor sleep quality may contribute to sarcopenia, but evidence remains sparse. This retrospective cross-sectional study investigated the association between subjective sleep quality and probable sarcopenia in a cohort of community-dwelling older adults enrolled in the Longevity Check-Up 8+ study.</p><p><strong>Methods: </strong>Participants were asked about their sleep quality over the past month, with four possible options (\"very good\", \"quite good\", \"quite bad\", very bad\"). For the analysis, participants were grouped into good or bad sleep quality categories. Probable sarcopenia was operationalized according to handgrip strength values < 27 kg for men and < 16 kg for women. Logistic regression models were used to explore the relationship between sleep quality and probable sarcopenia.</p><p><strong>Results: </strong>1971 participants were included in the analysis (mean age 73.4 ± 6.2 years, 50.0 % women). Bad sleep quality was reported by 28.3 % of participants and was more prevalent among women, physically inactive individuals, and those with dyslipidemia. Probable sarcopenia was more prevalent in participants with bad sleep quality (23.8 % vs. 18.7 %, p = 0.012). Logistic regression revealed that bad sleep quality was significantly associated with increased odds of probable sarcopenia in both unadjusted (odds ratio [OR] 1.36, 95 % confidence interval [CI] 1.07-1.72, p = 0.010) and fully adjusted models (OR 1.40, 95 % CI 1.08-1.81, p = 0.011).</p><p><strong>Conclusions: </strong>Poor sleep quality is associated with increased likelihood of probable sarcopenia in older adults. This finding highlights the importance of addressing sleep quality in interventions aimed at preventing sarcopenia and promoting healthy aging.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112666"},"PeriodicalIF":3.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of utility of wearable sensor technologies for older person frailty assessment.","authors":"Chen Yixiao, Shen Hui, Song Quhong, Zeng Xiaoxi, Yue Jirong","doi":"10.1016/j.exger.2024.112668","DOIUrl":"https://doi.org/10.1016/j.exger.2024.112668","url":null,"abstract":"<p><p>Frailty is one of the most concerning aspects of global population aging, and early identification is crucial to prevent or reverse its progression. Simple, universal, and efficient frailty assessment technologies are essential for the timely detection of frailty in older patients. Various multi-dimensional assessment instruments have been developed to quantify frailty phenotypes; we review the literature on wearable sensor technologies leveraged for older person frailty assessment. This review examines representative studies on older person frailty assessment published up to 2024, summarizing pertinent wearable sensor technologies utilized for frailty assessment. Our findings suggest that objective, simple, rapid, and affordable sensor-based frailty screening holds utility across diverse applications including diagnostic aid, prognostication, and endpoint ascertainment in research.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112668"},"PeriodicalIF":3.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics.","authors":"Guilherme da Silva Rodrigues, Andressa Crystine da Silva Sobrinho, Gabriel Peinado Costa, Leonardo Santos Lopes da Silva, João Gabriel Ribeiro de Lima, Leonardo da Silva Gonçalves, Larissa Chacon Finzeto, Carlos Roberto Bueno Júnior","doi":"10.1016/j.exger.2024.112669","DOIUrl":"https://doi.org/10.1016/j.exger.2024.112669","url":null,"abstract":"<p><p>This study employed multivariate analysis to investigate the effects of a 14-week multicomponent training program on sedentary adults and older populations, focusing on improvements in physical fitness, health markers, and anthropometric measures. The data included 376 participants aged 30 to 84 years who had been inactive for at least 3 months. Results showed that participants aged 71 and above had lower systolic blood pressure, height, body mass, elbow flexion and extension, sitting and standing up from a chair, agility, 6-Minute Walk Test (6MWT), and handgrip strength values compared to younger age groups (p < 0.05). Initially, the 6MWT was inversely correlated with anthropometric measures and positively correlated with strength tests, but after the intervention, it remained correlated only with handgrip strength and agility. Interestingly, the elbow flexion and extension strongly correlated with other fitness measures pre-intervention, but these relationships weakened afterward. Agility became a key intermediary variable in the analysis. Despite improvements, anthropometric variables like body mass and waist circumference continued to have a strong relationship with fitness outcomes. Significant gains were observed in the 6MWT and elbow flexion and extension (p < 0.05), indicating improvements in aerobic fitness and strength. Multivariate analysis showed that hip circumference, chair stand test, handgrip strength, and agility significantly influenced 6MWT performance. Using multivariate analysis, we were able to highlight the importance of incorporating regular exercise into daily life to promote active and healthy aging. Furthermore, agility emerged as the most significant intermediate variable after the intervention. This insight suggests that improvements in agility may be crucial for physical fitness and overall health.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112669"},"PeriodicalIF":3.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shadow puppetry therapy enhances dementia-related cognitive function and interpersonal relationship.","authors":"Shu-Yuan Chao, Hsiao-Mei Chen, Bei-Yi Su","doi":"10.1016/j.exger.2024.112667","DOIUrl":"10.1016/j.exger.2024.112667","url":null,"abstract":"<p><strong>Background: </strong>With the growing demand for dementia care, non-pharmacological interventions, such as creative arts therapies, have been proven effective in stabilizing cognitive function. Shadow Puppetry Therapy (SPT), which integrates visual, auditory, and kinesthetic elements, offers a promising care option for individuals with dementia.</p><p><strong>Objective: </strong>This study evaluated the effectiveness of SPT on cognitive function, self-esteem, and interpersonal relationships among older adults with mild dementia.</p><p><strong>Methods: </strong>We adopted a quasi-experimental design and recruited 33 older adults with mild dementia from two dementia care centers. Older adults with mild dementia were randomly assigned to an experimental group (n = 15) and a control group (n = 18). The experimental group participated in a 16-week SPT program, and the control group engaged in regular activities, such as physical exercises, painting, cooking, music, and handicraft projects. Assessments included the short portable mental status questionnaire (SPMSQ), the Rosenberg self-esteem scale (RSES), and the interpersonal relationship scale, with evaluations conducted before and after the intervention.</p><p><strong>Results: </strong>The intervention significantly improved cognitive function, self-esteem, and interpersonal relationships in the experimental group. SPMSQ scores decreased, indicating enhanced cognitive function (p = .001), while self-esteem and interpersonal relationship scores showed significant improvements (p = .001). No significant changes were observed in the control group.</p><p><strong>Conclusion: </strong>SPT is an effective non-pharmacological intervention for enhancing cognitive function, self-esteem, and interpersonal relationships in older adults with mild dementia. The findings support the integration of creative arts therapies into dementia care.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112667"},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017-2018 and Mendelian randomization analysis.","authors":"Xuehua Wang, Qian Xu, Wenhu Liu, Jingjie Xiong, Han Li, Ni Xiong, Yan Wang, Zhaohui Wang","doi":"10.1016/j.exger.2024.112665","DOIUrl":"10.1016/j.exger.2024.112665","url":null,"abstract":"<p><strong>Objective: </strong>Cardiovascular diseases (CVDs) and cancer are significant global causes of mortality. However, the link between diets that promote inflammation and various subtypes of CVDs and cancers remains unclear.</p><p><strong>Methods: </strong>Utilizing the dataset from the 2017-2018 National Health and Nutrition Examination Survey (NHANES) data release cycle, our study encompassed 3538 adult participants within the age range of 20 to 80 years. The dietary questionnaire information was utilized to calculate dietary inflammatory index (DII) scores. Logistic regression analysis was employed to validate the association between the DII and CVDs, as well as overall cancer and special type cancer. Mediation analysis was conducted to evaluate the relationship between DII and the aforementioned diseases, with hemoglobin serving as the potential mediator. Mendelian randomization (MR) analysis externally validated hemoglobin's causal link to these diseases.</p><p><strong>Results: </strong>Patients with the highest quartile levels of DII scores demonstrated an elevated prevalence of congestive heart failure (CHF), stroke, overall cancer and some specific types of cancers. The logistic regression analysis revealed a correlation between DII and CHF (OR = 1.197, p = 0.002), stroke (OR = 1.205, p < 0.001), as well as breast cancer (OR = 1.306, p = 0.004). The pro-inflammatory diet also resulted in lower hemoglobin levels (p < 0.001). Mediation analyses found a role for hemoglobin in the relationship of DII and CVDs.</p><p><strong>Conclusions: </strong>Both CVDs and cancer risk were positively correlated with the DII in our study. Hemoglobin emerged as a potential mediator in the intricate relationship between DII and CHF, as well as stroke.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112665"},"PeriodicalIF":3.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly.","authors":"Mahdie Dehnavi, Najmeh Valizadeh Zare, Seyd Reza Mazlom, Samira Mohajer, Tahereh Sadeghi, Mohammad Namazinia, Danial Baghie","doi":"10.1016/j.exger.2024.112661","DOIUrl":"10.1016/j.exger.2024.112661","url":null,"abstract":"<p><strong>Background: </strong>The increasing elderly population is a complex and globally significant phenomenon impacting various sectors of society, including healthcare. By 2050, it is projected that one-fourth of Iran's population will be elderly. Falls are a major concern among the elderly, leading to physical and psychological injuries and imposing significant financial burdens on healthcare and social systems. Given the widespread acceptance of smartphones and mobile health applications, however limited research has been conducted on the effectiveness of mobile applications in training caregivers for home safety and accident prevention in elderly populations.</p><p><strong>Methods: </strong>This randomized clinical trial was conducted in 2022 in Mashhad, Iran. The sample consisted of 66 elderly caregivers, randomly assigned to intervention and control groups. Data collection tools included a demographic information questionnaire and the Home Safety Self-Assessment Tool (HSSAT). The intervention group used a home safety educational application, while the control group received educational brochures. Data were analyzed using SPSS software and appropriate statistical tests.</p><p><strong>Results: </strong>Sixty-two elderly caregivers participated in the study, with a mean age of 72 ± 37.7 years. The chi-square test showed no significant difference in gender distribution between the intervention and control groups (p = 0.060). The majority of participants in both groups had a high school education. Before the training, there was no significant difference in the mean accident risk management scores between the two groups (p = 0.713). Repeated measures ANOVA revealed a significant time effect (F(1, 60) = 408, p < 0.001, Partial η² = 0.872) and a significant group effect (F(1, 60) = 5, p = 0.025, Partial η² = 0.081). Additionally, the interaction between time and group was significant (F(1, 60) = 6, p = 0.015, Partial η² = 0.095), indicating a greater improvement in accident risk management scores in the intervention group compared to the control group.</p><p><strong>Conclusions: </strong>The use of home safety educational applications can effectively reduce the risk of accidents and improve preventive measures management among the elderly. These modern educational tools can alleviate the burden on healthcare systems and save costs associated with in-person training. Future research should continue exploring innovative educational methods to enhance the safety and well-being of the elderly population.</p><p><strong>Trial registration: </strong>This study was registered in the Iranian Registry of Clinical Trials (no. IRCT20210610051532N1) on 07/09/2021.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112661"},"PeriodicalIF":3.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}