Experimental gerontology最新文献

{"title":"Association between body roundness index with femoral neck bone mineral density, osteoporosis, and FRAX score in middle-aged and older adults: A cross-sectional study","authors":"Wentao Xiao ,&nbsp;Yi Wang ,&nbsp;Taichuan Xu ,&nbsp;Chao Li ,&nbsp;Xian Zhang","doi":"10.1016/j.exger.2025.112848","DOIUrl":"10.1016/j.exger.2025.112848","url":null,"abstract":"<div><h3>Background</h3><div>The clinical usefulness of the body roundness index (BRI) in predicting bone health outcomes, including femoral neck bone mineral density (FN BMD), osteoporosis, and fracture risk assessment (FRAX) scores, remains unvalidated in middle-aged and elderly populations.</div></div><div><h3>Methods</h3><div>Based on NHANES data from 2013 to 2014, we included 2215 adults. Weighted multiple linear regression and logistic regression models were used to investigate the relationship between BRI and FN BMD, osteoporosis, and FRAX scores. Non-linear correlations were examined using the restricted cubic spline (RCS) model.</div></div><div><h3>Results</h3><div>The regression analyses indicated a robust positive correlation between BRI and FN BMD, with each unit boost in BRI leading to a 0.018 g/cm² increase in FN BMD (β = 0.018, 95 %CI: 0.015, 0.021). A substantial negative association was found between BRI and osteoporosis (OR = 0.804, 95 %CI: 0.714, 0.906). Furthermore, the BRI was significantly and negatively associated with FRAX scores. RCS revealed a linear positive correlation between BRI and FN BMD and a negative linear correlation with osteoporosis and a negative non-linear correlation with FRAX scores.</div></div><div><h3>Conclusion</h3><div>This cross-sectional study elucidated that the BRI demonstrates a complex relationship with various bone health parameters, including a significant positive correlation with FN BMD and a significant negative correlation with osteoporosis prevalence and FRAX scores. However, it was unable to establish a causal relationship between the BRI and these various bone health parameters.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112848"},"PeriodicalIF":4.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of home-based slow-paced breathing on functional performance in middle-aged women: A randomized controlled trial study","authors":"Karama Masmoudi ,&nbsp;Fatma Chaari ,&nbsp;Haithem Rebai ,&nbsp;Sonia Sahli","doi":"10.1016/j.exger.2025.112854","DOIUrl":"10.1016/j.exger.2025.112854","url":null,"abstract":"<div><div>As individuals age, functional performance declines, particularly affecting mobility, strength, and postural balance, with middle-aged women experiencing earlier and more pronounced impairments due to menopausal transition. Given the low adherence to traditional exercise programs among this population, home-based slow-paced breathing (SPB) presents a promising accessible alternative. Hence, this study aimed to examine the effects of a 12-week daily SPB intervention on functional performance in middle-aged women.</div><div>Twenty-six middle-aged women were randomized into an experimental group (EG), which practiced home-based SPB, or a control group (CG), which continued their usual activities. Static postural balance, upper- and lower-limb muscle strength, mobility and dynamic balance, and aerobic endurance were evaluated at pre-intervention, post-4, post-8, and post-12 weeks of intervention.</div><div>Static postural balance improved on a firm surface within the EG post-12 weeks of intervention, though no significant differences emerged between groups. On a foam surface, improvements emerged post-8 weeks in the eyes-open condition and post-4 weeks in the eyes-closed condition. Additionally, aerobic endurance improved within the EG post-8 weeks, with no significant differences between groups. No significant group x session interactions were found for other functional performances.</div><div>These findings indicate that middle-aged women who practiced or not the SPB demonstrated similar functional outcomes, suggesting that SPB alone may not be sufficient to induce significant improvements in functional performances. Exploring the effects of integrating SPB with muscle-strengthening exercises or neuromuscular training could be interesting to determine whether a combined approach could yield greater functional benefits and address the limitations of the observed non-significant results.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112854"},"PeriodicalIF":4.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between visceral fat accumulation and sarcopenia: A cross-sectional study","authors":"Shengwei Wang ,&nbsp;Weigen Wu ,&nbsp;Ling Zhang ,&nbsp;Qi Zeng ,&nbsp;Yu Luo ,&nbsp;Weiwen He ,&nbsp;Wei Chen ,&nbsp;Wen He","doi":"10.1016/j.exger.2025.112849","DOIUrl":"10.1016/j.exger.2025.112849","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of sarcopenia is increasing annually, and tools for assessing its risk remain limited. Visceral fat accumulation is closely associated with sarcopenia.</div></div><div><h3>Methods</h3><div>Data from 5200 participants in NHANES 2011–2018 were analyzed. Six visceral fat accumulation indicators, namely relative fat mass (RFM), lipid accumulation product (LAP), weight-adjusted waist index (WWI), triglyceride glucose-waist-to-height ratio (TyG-WHtR), metabolic score for insulin resistance (METS-IR), and metabolic score for visceral fat (METS-VF), were evaluated and compared for their associations with sarcopenia using multivariable logistic regression, smoothed curve fitting and threshold effect analysis. This study aimed to develop nine machine learning (ML) models incorporating visceral fat indicators to predict the risk of sarcopenia, with Shapley Additive Explanations (SHAP) applied to enhance model interpretability.</div></div><div><h3>Results</h3><div>Visceral fat accumulation indicators were substantially associated with the risk of sarcopenia. Threshold effect analysis revealed that the saturation points for RFM, LAP, WWI, TyG-WHtR, METS-IR, and METS-VF in sarcopenia were 41.844, 76.747, 11.352, 4.777, 50.525, and 6.806, respectively. The logistic regression model exhibited the highest predictive performance with an area under the receiver operating characteristic curve (AUC-ROC) of 0.878. WWI was identified as the strongest predictor of sarcopenia risk in the SHAP analysis.</div></div><div><h3>Conclusion</h3><div>All visceral fat accumulation indicators were positively associated with sarcopenia risk and WWI identified as the most important predictor. The ML model achieved high predictive accuracy, highlighting the role of visceral fat accumulation in sarcopenia risk and healthy aging promotion.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112849"},"PeriodicalIF":4.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of different frailty assessment tools in older patients undergoing major abdominal surgery","authors":"Junli You ,&nbsp;Xuepiao Chen ,&nbsp;Yu Rong ,&nbsp;Sining Pan ,&nbsp;Tianxiao Liu ,&nbsp;Yubo Xie","doi":"10.1016/j.exger.2025.112852","DOIUrl":"10.1016/j.exger.2025.112852","url":null,"abstract":"<div><h3>Background</h3><div>Multiple frailty assessment tools are available for clinical practice, but the optimal tool remains unclear. This study aimed to compare the diagnostic performance of frail scale (FS), frailty phenotype (FP),11-item modified frailty index (mFI-11), Edmonton Frail Scale (EFS), and Tilburg Frailty Indicator (TFI) for frailty taking the comprehensive geriatric assessment (CGA) as the gold standard, and their ability to predict 30-day postoperative complications and prolonged length of stay (PLOS).</div></div><div><h3>Methods</h3><div>This study recruited older patients (≥ 65 years) undergoing elective major abdominal surgery. The receiver operating characteristic (ROC) curves, technique for order preference by similarity to ideal solution (TOPSIS), and decision analysis curve (DCA) were used to validate the diagnostic, comprehensive, and predictive performance of 5 tools in frailty, complications, and PLOS.</div></div><div><h3>Results</h3><div>EFS presented moderate consistency with CGA (Kappa = 0.544, <em>P</em> &lt; 0.001), excellent performance in diagnosing frailty (area under the ROC curve (AUC) = 0.881, <em>P</em> &lt; 0.001), and high clinical net benefit within the risk threshold ranging from 0.8 % to 57.44 %. Although EFS had the largest AUC for predicting complications (AUC = 0.612) and PLOS (AUC = 0.642) and showed high clinical net benefit, its predictive performance was poor (AUC &lt; 0.7). The TOPSIS indicated that EFS required optimization in multiple aspects (closeness coefficient (Ci) &lt; 0.8).</div></div><div><h3>Conclusion</h3><div>EFS has excellent diagnostic performance and clinical net benefit for frailty. However, further research is required to identify optimal tools or combine EFS with additional indicators to enhance its comprehensive and predictive performance for complications and PLOS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112852"},"PeriodicalIF":4.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do older adults with and without a history of falls show different gait patterns in response to individualized treadmill perturbations?","authors":"Michel Hackbarth, Tania Zieschang, Sandra Lau, Jessica Koschate-Storm","doi":"10.1016/j.exger.2025.112853","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112853","url":null,"abstract":"<p><strong>Background: </strong>Dynamic reactive balance is key to avoid falls during walking and can be challenged with treadmill-based gait perturbations. The use of mechanical gait perturbations to measure reactive dynamic balance performance, is discussed to identify individuals at risk of falling. Gait speed and perturbation intensity, are often standardized in study populations. In heterogeneous study populations, this entails the risk of either overburdening the participants or failing to adequately challenge them.</p><p><strong>Research question: </strong>Are gait parameters and compensatory steps, after mechanical treadmill-based perturbations using perturbation intensities at the individual single step threshold and preferred walking speed, different between younger and older adults with or without a history of falling?</p><p><strong>Methods: </strong>In this study, 86 younger and older adults with and without a history of falls completed two treadmill-walking trials with mediolateral and anteposterior perturbations. Step length and step width were analyzed before and after perturbations using ANOVA with repeated measures.</p><p><strong>Results: </strong>The adjustments of both parameters to individualized mediolateral perturbations differed between younger and older participants, while between older adults with and without a history of falls, only small differences in step width (p < 0.001, η_p² = 0.141) were observed.</p><p><strong>Significance: </strong>Individually tailored treadmill-perturbations can be safely applied in older adults. Compensatory steps as a reaction to perturbations differ between younger and older adults. However, at the individual limit of balance control, differences between older adults with and without a history of falls are small.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112853"},"PeriodicalIF":4.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acute response of irisin to resistance and endurance exercise at both lower and higher intensities in healthy older adults","authors":"James E. Newman ,&nbsp;Isabel King ,&nbsp;Nicole Flemming ,&nbsp;Kathryn M. Broadhouse ,&nbsp;Robert Buhmann ,&nbsp;Grace L. Rose ,&nbsp;David G. Jenkins ,&nbsp;Christopher D. Askew ,&nbsp;Mia A. Schaumberg","doi":"10.1016/j.exger.2025.112850","DOIUrl":"10.1016/j.exger.2025.112850","url":null,"abstract":"<div><div>Exercise-induced release of irisin may contribute to the beneficial effects of exercise on brain health. Previous studies in healthy adults have shown ~15 % increase in short-term post-exercise irisin concentrations. However, previous research investigating the exercise-induced release of irisin in older populations is scarce and findings are highly variable. The present study investigated the effects of exercise mode and intensity on short-term acute post-exercise irisin concentrations in older adults. Thirty-two healthy older adults (women n = 18, men n = 14, age 72 ± 5 years), completed a randomised cross over study of four single-bout exercise sessions on separate days, consisting of either: lower-intensity resistance exercise (Low-RE), higher-intensity resistance exercise (High-RE), lower-intensity endurance exercise (Low-EE) or higher-intensity endurance exercise (High-EE) as well as a seated rest control (RC). Serum irisin concentrations were measured at pre- and 0-, 30-, and 60-min post-exercise. Body composition, peak oxygen consumption and one repetition maximum were evaluated to inform individual exercise intensities. Irisin concentrations were increased immediately after High-RE, High-EE, and Low-EE and remained elevated after Low-EE at 30 min post-exercise. Irisin concentrations were greater after Low-EE than High-EE at 30-min post-exercise, and greater after High-RE than Low-RE at 60-min post-exercise. Healthy older adults exhibit a short-term acute peak irisin response to exercise (~17 %) comparable to that previously observed in younger populations (~15 %), highlighting the potential for exercise-induced benefits on brain health irrespective of age. Given that resistance and endurance exercises at different intensities elicit distinct responses, intensity, resistance volume, endurance session duration and mode must be considered when designing optimal exercise prescriptions for improved brain health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112850"},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and assessment of an early diagnostic approach for painful diabetic peripheral neuropathy using basic clinical and laboratory parameters","authors":"Yue Yang ,&nbsp;Lu Liu ,&nbsp;Hui-Hui Wang ,&nbsp;Yan Lu ,&nbsp;Jiang-Ping Li ,&nbsp;Ping Liu ,&nbsp;Zi-Cheng Hu ,&nbsp;Xiao Yang","doi":"10.1016/j.exger.2025.112847","DOIUrl":"10.1016/j.exger.2025.112847","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to construct a predictive model for the onset of painful diabetic peripheral neuropathy (PDPN) in patients with diabetic peripheral neuropathy (DPN).</div></div><div><h3>Methods</h3><div>The clinical and laboratory data of 783 patients with DPN were retrospectively analyzed to form the modeling group. A Douleur Neuropathique 4 score of ≥4 was used to identify neuropathic pain (NP), and such patients were categorized into the PDPN group. Potential predictive variables were screened using least absolute shrinkage and selection operator (LASSO) regression. Logistic regression was subsequently used to construct a predictive model for PDPN. The discriminatory power and calibration of the model were assessed using receiver operator characteristic (ROC) curve analysis and calibration plots. For validation, the model was tested on an independent group of 350 patients with DPN.</div></div><div><h3>Results</h3><div>The final modeling and validation groups comprised of 359 and 162 patients with PDPN, respectively. The inclusion of five clinical variables resulted in an optimal predictive model: hemoglobin A1c (HbA1c) (odds ratio [OR] = 1.173, P &lt; 0.001), triglycerides (TG) (OR = 1.813, P &lt; 0.001), body mass index (BMI) (OR = 1.081, P = 0.002), disease duration (OR = 1.066, P &lt; 0.001), and 24-hour urine microalbumin (UMA) (OR = 1.003, P &lt; 0.001). The areas under the ROC curve for the modeling and validation groups were 0.812 and 0.850, respectively. The calibration plot demonstrated a close fit between the calibration curve and the ideal curve, with Hosmer–Lemeshow P values of 0.4153 for the modeling group and 0.8413 for the validation group.</div></div><div><h3>Conclusion</h3><div>These findings indicate that our nomogram can effectively predict the occurrence of PDPN in patients with DPN, thereby assisting clinicians in identifying patients at risk.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112847"},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis","authors":"Lei Wu ,&nbsp;Hengheng Zhang ,&nbsp;Yongwen Li ,&nbsp;Jinxin Tang ,&nbsp;Dengwen wang ,&nbsp;Linrong Zhu","doi":"10.1016/j.exger.2025.112842","DOIUrl":"10.1016/j.exger.2025.112842","url":null,"abstract":"<div><h3>Background</h3><div>Insomnia and osteoporosis are both prevalent conditions with rising incidence. Observational studies have suggested that insomnia may lead to thyroid dysfunction, which in turn contributes to osteoporosis. However, the interplay among these three conditions remains unexamined. This study aimed to investigate the causal association between insomnia and osteoporosis, while also analyzing whether thyroid dysfunction mediates this relationship.</div></div><div><h3>Method</h3><div>A two-sample Mendelian randomization approach was applied to examine the genetic association between insomnia and osteoporosis. Mediator MR was subsequently used to assess the intermediary role of thyroid dysfunction. The inverse variance weighting method served as the primary analytical strategy. Heterogeneity was evaluated using MR-Egger's intercept, Cochran's Q test, and leave-one-out analysis. The MR-PRESSO test was conducted to assess horizontal pleiotropy. To ensure robustness, FDR correction was applied.</div></div><div><h3>Results</h3><div>A genetic association between insomnia and osteoporosis was observed (IVW: OR = 1.004, <em>p</em> = 0.007). Insomnia showed a genetic link with hypothyroidism (IVW: OR = 1.010, <em>p</em> = 0.00075), but not with hyperthyroidism, Hashimoto's thyroiditis, or Graves' disease (<em>p</em> &gt; 0.05). Mediator MR revealed that hypothyroidism accounted for 6.29 % (6.27 %–6.31 %) of the effect of insomnia on osteoporosis.</div></div><div><h3>Conclusion</h3><div>This study supports a causal link between insomnia and osteoporosis. Hypothyroidism plays a mediating role in this pathway. Targeting hypothyroidism may lower the risk of osteoporosis associated with insomnia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112842"},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good sleep quality predicts a lower risk of osteoporosis in older adults: Evidence from the English longitudinal study of ageing","authors":"Mixue Guo ,&nbsp;Mengyuan Cai ,&nbsp;Huqiang Dong ,&nbsp;Hongli Wan ,&nbsp;Zongren Zhao ,&nbsp;Luming Wei ,&nbsp;Qixin Chen","doi":"10.1016/j.exger.2025.112844","DOIUrl":"10.1016/j.exger.2025.112844","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis is an increasingly prevalent public health concern in ageing populations. While traditional risk factors such as ageing, hormonal status, and physical inactivity are well-recognized, the role of sleep quality in osteoporosis risk remains understudied. This study aimed to investigate the prospective association between sleep quality and the risk of developing osteoporosis among older adults.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using data from the English Longitudinal Study of Ageing (ELSA). A total of 5958 osteoporosis-free participants aged ≥50 years were recruited at wave 4 (2008–2009) and followed up across waves 5 to 8 (2016–2017), with a maximum follow-up of 8 years. Sleep quality was assessed using a validated four-item questionnaire (score range: 4–16), and categorized as good (4 ≤ score ≤ 7), intermediate (8 ≤ score ≤ 11), and poor (12 ≤ score ≤ 16) sleep quality groups. Incident osteoporosis was identified via self-reported physician diagnosis. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs), adjusting for demographic, socioeconomic, lifestyle, and health-related covariates including sleep duration.</div></div><div><h3>Results</h3><div>During the 8-year follow-up, 319 participants (5.36 %) developed osteoporosis. Compared to those with poor sleep quality, the risk of osteoporosis was significantly lower in the intermediate (adjusted HR = 0.64, 95 % CI: 0.49–0.85) and good sleep quality groups (adjusted HR = 0.54, 95 % CI: 0.39–0.73). A significant dose–response relationship was observed (P for trend &lt;0.001). These associations remained robust among participants with normal sleep duration (6–9 h). Subgroup analyses revealed that the associations were particularly significant in adults aged 60–80 years, those who were married or cohabiting, and individuals with hypertension, even after Bonferroni correction.</div></div><div><h3>Conclusions</h3><div>Higher sleep quality was significantly associated with a reduced risk of osteoporosis among older adults. These findings suggest that sleep quality may be a potentially modifiable behavioral factor related to osteoporosis risk, warranting further investigation in future longitudinal and interventional studies.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112844"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary inflammatory index and endometriosis in the US population: A cross-sectional study","authors":"Yan Chen ,&nbsp;Meng Yu ,&nbsp;Shan Hu ,&nbsp;Donghui Yu ,&nbsp;Ying Zhao","doi":"10.1016/j.exger.2025.112846","DOIUrl":"10.1016/j.exger.2025.112846","url":null,"abstract":"<div><h3>Background</h3><div>Endometriosis is a chronic inflammatory disorder affecting reproductive-aged women. The Dietary Inflammatory Index (DII), a measure of diet-related inflammation, has been implicated in various inflammatory diseases, but its role in endometriosis remains unclear.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed 4149 women from the NHANES 2001–2006, including 287 with endometriosis. DII scores were derived from dietary data and categorized into quartiles. Logistic regression models were used to assess the association between DII and endometriosis, adjusting for confounders. Restricted cubic splines (RCS) were applied to explore non-linear trends, and subgroup analyses evaluated effect modifications. LASSO regression identified key predictors, and a nomogram was developed for risk prediction.</div></div><div><h3>Results</h3><div>Women with endometriosis had higher DII scores than those without (1.69 ± 1.76 vs. 1.48 ± 1.74, <em>P</em> = 0.044). In fully adjusted models, the odds of endometriosis increased with higher DII quartiles (Q4 vs. Q1: OR1.40, 95 % CI: 1.02–1.98, <em>P</em> for trend &lt; 0.001). While non-linear trends were not statistically significant (<em>P</em>-non-linear = 0.128), RCS analysis suggested a steeper risk increase at higher DII levels. Subgroup analyses indicated stronger associations among older women, those with higher BMI, and smokers. The nomogram achieved moderate predictive performance (AUC: 66.6 %, 95 % CI: 63.7–69.5 %).</div></div><div><h3>Conclusion</h3><div>Higher DII scores are associated with increased odds of endometriosis. Dietary interventions targeting inflammation may offer a novel approach to managing endometriosis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112846"},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}