Experimental gerontology最新文献

{"title":"The relationship between youth obesity and metabolic syndrome among middle-aged and elderly adults in the United States","authors":"Gang Cheng ,&nbsp;Ying Zhou ,&nbsp;Yan Wang,&nbsp;Chunguang Wang,&nbsp;Jianghong Xu","doi":"10.1016/j.exger.2025.112806","DOIUrl":"10.1016/j.exger.2025.112806","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to observe the relationship between youth obesity and metabolic syndrome (MetS) among middle-aged and elderly adults in the United States.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted on United States adults aged ≥50 years. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 cycles. The levels of height and weight at aged 25 years were obtained. Body mass index (BMI) at aged 25 years (BMI₂₅) was calculated. Healthy weight, overweight and obesity at aged 25 years (healthy weight₂₅, overweight₂₅ and obesity₂₅) were defined as BMI₂₅ 18.5 to &lt;25 kg/m², 25 to &lt;30 kg/m² and 30 kg/m² or greater. MetS was defined According to the National Cholesterol Education Program's Adult Treatment Panel III report (ATP III).</div></div><div><h3>Results</h3><div>The prevalences of MetS were 48.7 %, 63.5 %, and 71.4 % in adults with healthy weight₂₅, overweight₂₅, and obesity₂₅ group. After control for confounding factors, the prevalences of MetS in overweight₂₅ group and obesity₂₅ group were 2.147 (95%CI: 1.892–2.436, <em>P</em> &lt; 0.001) times and 2.878 (95%CI: 2.304–3.597, <em>P</em> &lt; 0.001) times than that in healthy weight₂₅ group. After further adjusted for BMI at the time of survey, the prevalences of MetS in adults with overweight₂₅ group and obesity₂₅ group were 1.193 (95%CI:1.035–1.375，<em>P</em> = 0.015) times and 1.222 (95%CI:0.959–1.557，<em>P</em> = 0.105) times than adults with healthy weight₂₅ group.</div></div><div><h3>Conclusion</h3><div>The present study demonstrates that youth obesity was closely associated with an increased risk of MetS among middle-aged and elderly adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112806"},"PeriodicalIF":3.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of chronic knee pain and age on conditioned pain modulation and motor unit control","authors":"Emily J. Parsowith ,&nbsp;Emma Herring ,&nbsp;Brandon Cohen ,&nbsp;Kevan S. Knowles ,&nbsp;Ethan C. Hill ,&nbsp;Meredith Chaput ,&nbsp;Abigail W. Anderson ,&nbsp;Matt S. Stock","doi":"10.1016/j.exger.2025.112803","DOIUrl":"10.1016/j.exger.2025.112803","url":null,"abstract":"<div><h3>Background</h3><div>Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of the underlying mechanisms hinders the development of effective treatments.</div></div><div><h3>Purpose</h3><div>This study integrated assessments of Conditioned Pain Modulation (CPM) and motor unit control to elucidate the role of pain sensitization and neuromuscular impairments specific to chronic knee pain.</div></div><div><h3>Methods</h3><div>Seventy-five participants were divided into three groups: young adults (n = 25), older adults without pain (n = 30), and older adults with chronic pain (n = 20). CPM efficiency was evaluated using heat and pressure test stimuli alongside a cold-water bath conditioning stimulus. Motor unit assessments involved isometric contractions of the dominant/painful quadriceps at 50 % of maximal torque, with surface electromyographic signals recorded from the vastus lateralis.</div></div><div><h3>Results</h3><div>Independent of chronic knee pain, older adults demonstrated more efficient heat-CPM than young adults (<em>p</em> = 0.014, η_p² = 0.080). The slope of the mean firing rate versus recruitment threshold relationship indicated that older adults showed greater firing rates for high threshold motor units, independent chronic knee pain (<em>p</em> = 0.010, ηp² = 0.136). The y-intercept of this relationship was greater in younger versus chronic-pain older adults (<em>p</em> = 0.024, ηp² = 0.111).</div></div><div><h3>Conclusion</h3><div>Contrary to our hypothesis, older adults displayed more efficient heat-CPM, independent of chronic pain. Similarly, motor unit control was mostly influenced by age but not chronic knee pain. These findings suggest that age-related changes in pain modulation and motor unit behavior may play a greater role in neuromuscular function than the presence of chronic pain itself.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112803"},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic oxidative stress associates with delirium in a geriatric population with hip fracture","authors":"Monika Trzpis ,&nbsp;Maria Zernova ,&nbsp;Karin M. Vermeulen ,&nbsp;Marian L.C. Bulthuis ,&nbsp;Marjan Reinders-Luinge ,&nbsp;Harry van Goor ,&nbsp;Barbara C. van Munster ,&nbsp;Arno R. Bourgonje","doi":"10.1016/j.exger.2025.112801","DOIUrl":"10.1016/j.exger.2025.112801","url":null,"abstract":"<div><h3>Background</h3><div>Oxidative stress ensues in patients undergoing surgery for hip fracture and has been implicated in the pathophysiology of delirium. Circulating free thiols (R-SH, sulfhydryl groups) serve as biomarker of systemic oxidative stress since they are rapidly oxidized by reactive species, acting as potent antioxidants. We aimed to investigate the relationship between delirium and systemic oxidative stress in older patients hospitalized with hip fracture.</div></div><div><h3>Methods</h3><div>Patients aged 65 years or more, acutely admitted due to hip fracture, were included between 2005 and 2008. Delirium was diagnosed according to the DSM-IV criteria for delirium. Free thiols were determined in plasma samples that had been collected longitudinally during hospitalization for previous clinical trial, using colorimetric detection. Albumin-adjusted plasma free thiol concentrations were both cross-sectionally and longitudinally evaluated in relation to delirium.</div></div><div><h3>Results</h3><div>In total 813 plasma samples from 336 patients were analysed. Delirium was experienced by 110 (33 %) patients. Mean albumin-adjusted free thiols of patients who experienced delirium (7.3 ± SD 1.4 μM/g) was lower than that of non-delirious patients (7.5 ± SD 1.3 μM/g) (<em>P</em> = 0.050). Multivariable logistic regression analysis, adjusted for age, preexisting cognitive impairment, institutionalization, time to surgery, and complications, indicated that delirium was significantly inversely associated with albumin-adjusted free thiol concentrations (OR = 0.8, 95%CI 0.75–0.96). The significant association between delirium and albumin-adjusted free thiols tested in all the samples was also shown by linear mixed model analysis after adjusting for confounders (β = −0.292; 95%CI 0.04–0.55).</div></div><div><h3>Conclusions</h3><div>Reduced concentrations of free thiols, reflecting systemic oxidative stress, are associated with delirium onset among patients with hip fracture.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112801"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and cancer risk: A bidirectional two-sample Mendelian randomization study","authors":"Qian Wang ,&nbsp;Jia Li ,&nbsp;Hao Qiao ,&nbsp;Yuelang Zhang ,&nbsp;Ying Xu ,&nbsp;Rui Chen ,&nbsp;Kaishunzi Liu ,&nbsp;Shuqun Zhang ,&nbsp;Guihua Zhuang","doi":"10.1016/j.exger.2025.112802","DOIUrl":"10.1016/j.exger.2025.112802","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence suggests that metabolic syndrome (MetS) contributes to cancer development, but the causal relationship remains unclear. This study aimed to explore the potential causal associations between MetS and 50 types of cancer (including the main cancer subtypes) using bidirectional Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Genome-wide association study (GWAS) data were downloaded from the IEU-GWAS database and CNCR-CTGLAB. We investigated the causal associations between MetS and cancer via the inverse variance-weighted (IVW) method. We used sensitivity analyses, including Cochran's Q, MR-PRESSO, and MR-Egger intercept tests, to verify the reliability of the MR results. The P-value of the IVW analysis was adjusted for the false discovery rate (FDR) to avoid false-positive results.</div></div><div><h3>Results</h3><div>The results of the IVW analysis revealed that genetically predicted MetS was positively associated with an increased risk of 11 types of cancers (P-FDR &lt; 0.05, odds ratio [OR] = 1.23–3.01), including squamous cell lung cancer, lung cancer, endometrial cancer, endometrial cancer (endometrioid histology), endometrial cancer (non-endometrioid histology), rectal cancer, hepatic cancer, colorectal cancer, non-follicular lymphoma cancer, primary lymphoid and hematopoietic malignant neoplasm cancer, and thyroid cancer. Genetically predicted MetS was negatively associated with the risk of prostate cancer (P-FDR &lt; 0.05, OR = 0.87). The sensitivity analyses revealed no heterogeneity or horizontal pleiotropy (P &gt; 0.05) in the MR Egger intercept and MR-PRESSO tests, confirming the robustness of the results. Moreover, there were no reverse causalities between these cancers and MetS.</div></div><div><h3>Conclusion</h3><div>Our study revealed a positive causal relationship between genetically predicted MetS and lung cancer, lung squamous cell carcinoma, endometrial cancer, colorectal cancer, hepatic cancer, non-follicular lymphoma cancer, primary lymphoid and hematopoietic malignant neoplasm cancer, and thyroid cancer, and a negative causal relationship between genetically predicted MetS and prostate cancer, which provides important insights into the cancer prevention, treatment, and long-term health management of MetS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112802"},"PeriodicalIF":3.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydroacteoside rejuvenates senescence via TVP23C-CDRT4 regulation","authors":"Yoo Jin Lee ,&nbsp;Eun Seon Song ,&nbsp;Yun Haeng Lee ,&nbsp;Kyeong Seon Lee ,&nbsp;Byeonghyeon So ,&nbsp;Ji Ho Park ,&nbsp;Jee Hee Yoon ,&nbsp;Duyeol Kim ,&nbsp;Minseon Kim ,&nbsp;Hyung Wook Kwon ,&nbsp;Youngjoo Byun ,&nbsp;Ki Yong Lee ,&nbsp;Joon Tae Park","doi":"10.1016/j.exger.2025.112800","DOIUrl":"10.1016/j.exger.2025.112800","url":null,"abstract":"<div><div>One of the major factors inducing senescence is reactive oxygen species (ROS) produced from dysfunctional mitochondria. Therapeutic strategies that reduce mitochondrial ROS generation are considered essential for rejuvenating senescence, but effective methods have not yet been established. Here, we screened phenylpropanoids (PPs), secondary metabolites produced in response to oxidative stress in plants, and identified dehydroacteoside as a potential candidate. Dehydroacteoside restored mitochondrial function, thereby reducing mitochondrial ROS generated by inefficient electron transport. Furthermore, senescence-associated phenotypes were restored by dehydroacteoside-mediated ROS reduction. Using RNA sequencing, we identified <em>TVP23C-CDRT4</em> as a gene that plays a critical role in dehydroacteoside-mediated senescence rejuvenation. Knockdown of <em>TVP23C-CDRT4</em> showed similar effects to dehydroacteoside, reducing ROS and subsequently restoring senescence-associated phenotypes. Taken together, our study uncovered a novel mechanism by which dehydroacteoside reduces mitochondrial ROS generation, thereby restoring senescence. Our findings open the way to a new field of anti-aging therapy aimed at controlling senescence by modulating ROS production in mitochondria.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112800"},"PeriodicalIF":3.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychological assessment in cognitively healthy nonagenarians and centenarians: an updated systematic review and meta-analysis","authors":"Carlotta Gualco ,&nbsp;Paola Del Sette ,&nbsp;Carlo Chiorri ,&nbsp;Emilio Di Maria","doi":"10.1016/j.exger.2025.112796","DOIUrl":"10.1016/j.exger.2025.112796","url":null,"abstract":"<div><div>The assessment of cognitive impairment in individuals aged 90 years and older is based on normative data estimated in the younger elderly. A first systematic review had provided the reference values in the oldest population for a few neuropsychological tests. Robust estimations on additional cohorts are needed.</div><div>We designed a systematic review update (PROSPERO: CRD42022347327) encompassing the literature published from 2015 to June 2024, to include studies reporting raw neuropsychological test scores from at least ten individuals aged &gt;90 without dementia. All types of cohort studies were eligible. The data set from the previously published systematic review and the studies retrieved in the update process were pooled. Random effect meta-analysis was applied to estimate the updated mean and cut-off values.</div><div>The systematic workflow provided 11 articles eligible for data abstraction. Based on the pooled data we estimated the updated reference scores for MMSE, BNT-SF, Semantic Fluency, TMT-A, TMT-B, Digit span forward and Digit span backward. Moreover, we estimated for the first time the reference values for the Word List Immediate and Word List Delayed tasks.</div><div>The systematic review provided an updated set of norms for the neuropsychological test that are frequently used to assess the cognitive profile in individuals aged &gt;90 years. The heterogeneity of the assessments limited the quantitative synthesis. Further studies on large cohorts are needed to stratify the normative values by age, gender and education. The identification of country- and population-specific values would help clinicians and researchers to characterise the cognitive profile in the oldest old individuals.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"208 ","pages":"Article 112796"},"PeriodicalIF":3.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose to lymphocyte ratio as a predictor of all-cause and cancer-specific mortality in cancer patients: Insights from NHANES data","authors":"Xiuxiu Qiu ,&nbsp;Qi Gao","doi":"10.1016/j.exger.2025.112799","DOIUrl":"10.1016/j.exger.2025.112799","url":null,"abstract":"<div><h3>Background</h3><div>The glucose-to-lymphocyte ratio (GLR) is a crucial factor in predicting the prognosis of various cancers. Nevertheless, there is a lack of extensive research on the association between GLR and mortality rates among cancer patients.</div></div><div><h3>Methods</h3><div>This study utilized data from 1564 cancer patients who participated in the National Health and Nutrition Examination Surveys (NHANES) between 2001 and 2018.To assess the relationship between the glucose-to-lymphocyte ratio (GLR) and mortality rates in cancer patients, we employed a range of statistical techniques, including weighted Kaplan-Meier analysis and multivariate-adjusted Cox regression. Furthermore, we applied restricted cubic spline (RCS) analysis to explore the potential non-linear association between these variables. To validate our findings, subgroup analyses were conducted to ensure the robustness and reliability of the results.</div></div><div><h3>Results</h3><div>Over a median follow-up period of 89 months, the cohort recorded 536 deaths, including 171 due to cancer and 365 from other causes. The Kaplan-Meier curve demonstrated that individuals in the higher quartiles of GLR faced significantly increased mortality risks compared to those in the lower quartiles. Weighted Cox proportional hazards regression analysis showed that, among cancer patients, each one-unit increase in GLR was associated with a 5 % increase in all-cause mortality risk (HR = 1.05, 95 % CI: 1.02–1.08) and a 7 % increase in cancer-specific mortality risk (HR = 1.07, 95 % CI:1.01–1.14). Additionally, restricted cubic spline analysis indicated a non-linear relationship between GLR and mortality.</div></div><div><h3>Conclusion</h3><div>In cancer patients, elevated GLR levels are strongly associated with higher mortality from both all causes and cancer-specific deaths. This marker may serve as a reliable prognostic indicator in individuals with tumors.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112799"},"PeriodicalIF":3.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine and cellular senescence: from molecular pathways to populational health","authors":"Sergej M. Ostojic ,&nbsp;Viktória Prémusz ,&nbsp;Pongrác Ács","doi":"10.1016/j.exger.2025.112798","DOIUrl":"10.1016/j.exger.2025.112798","url":null,"abstract":"<div><div>Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to further delineate creatine's role in cellular senescence and age-associated dysfunctions. By integrating perspectives from molecular biology, gerontology, and applied physiology, this paper aims to advance the understanding of creatine-based strategies as potential interventions for promoting healthy aging and preventing senescence-associated conditions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112798"},"PeriodicalIF":3.9,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes","authors":"Yining Ding ,&nbsp;Rumeng Chen ,&nbsp;Zhiwei Zheng ,&nbsp;Shuling Xu ,&nbsp;Menghua Liu,&nbsp;Chunyan Hou,&nbsp;Sen Li","doi":"10.1016/j.exger.2025.112797","DOIUrl":"10.1016/j.exger.2025.112797","url":null,"abstract":"<div><h3>Background</h3><div>Innovative therapeutic approaches are essential for treating atrial fibrillation (AF), yet genetic support for AF-specific drug targets remains limited.</div></div><div><h3>Methods</h3><div>This Mendelian randomization (MR) study employed cis-expression quantitative trait loci (cis-eQTLs) to assess the causal relationships between gene expression and AF. After achieving significance in the UK Biobank following multiple testing adjustments and validation in FinnGen, colocalization analysis and protein quantitative trait loci (pQTL) analysis were carried out.</div></div><div><h3>Results</h3><div>In the UK Biobank, genetic expression of 65 genes showed significant correlation with AF risk, and 15 were replicated in FinnGen. Colocalization analysis identified three primary candidates: WDR1, ESR2, and CXCL10, with significant associations in inverse variance-weighted (IVW) analysis. ESR2 showed a positive association with AF (OR = 1.403; 95 % CI: 1.200–1.640), while WDR1 (OR = 0.800; 95 % CI: 0.734–0.871) and CXCL10 (OR = 0.814; 95 % CI: 0.738–0.897) were negatively associated. Given the absence of pQTL data for ESR2 and WDR1, pQTL analysis focused exclusively on CXCL10 (OR = 0.59; 95 % CI: 0.43–0.82). Results from both the MR-Egger and weighted median methods were predominantly in agreement with that from IVW analyses.</div></div><div><h3>Conclusion</h3><div>ESR2, WDR1 and CXCL10 emerge as promising therapeutic targets for AF.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112797"},"PeriodicalIF":3.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic disparities in the associations of age at last live birth with stroke and its subtypes among Chinese parous postmenopausal women: A prospective cohort study","authors":"Shiyi Shan ,&nbsp;Weidi Sun ,&nbsp;Jing Wu,&nbsp;Leying Hou,&nbsp;Zeyu Luo,&nbsp;Jiali Zhou,&nbsp;Jiayao Ying,&nbsp;Peige Song","doi":"10.1016/j.exger.2025.112791","DOIUrl":"10.1016/j.exger.2025.112791","url":null,"abstract":"<div><h3>Background</h3><div>As a pivotal reproductive factor, age at last live birth (ALLB) plays a critical role in a woman's health trajectory, including the risk of cardiovascular diseases.</div></div><div><h3>Methods</h3><div>In this prospective cohort study from the China Kadoorie Biobank (CKB), 148,456 parous postmenopausal women were included. ALLB was further classified equally into tertiles (&lt;26 years, 26–29 years, and ≥30 years). Total stroke and its three subtypes (ischemic stroke [IS], intracerebral hemorrhage [ICH], and subarachnoid hemorrhage [SAH]) were identified as outcomes. Cox proportional hazard regression was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations of ALLB with incident stroke and its subtypes. Latent class analysis (LCA) was employed to explore underlying socioeconomic status (SES) classes within women in urban and rural areas, and SES-stratified analysis was conducted. Population attributable fraction (PAF) was estimated to assess the impact of later ALLB on stroke at the population level.</div></div><div><h3>Results</h3><div>Compared with women with ALLB of &lt;26 years, women with later ALLB (26–29 years and ≥ 30 years) faced a higher risk of stroke, with the highest fully adjusted HRs (aHRs) observed in women whose ALLB was ≥30 years (total stroke: 3.88, 95 % CI 3.71–4.07; IS: 5.33, 95 % CI 5.05–5.63; ICH: 3.79, 95 % CI 3.36–4.29; SAH: 4.93, 95 % CI 3.41–7.12). The strongest associations were found among rural-low-SES participants with total stroke and IS, with aHRs of 5.61 (95 % CI 5.12–6.16) and 7.28 (95 % CI 6.51–8.14) for an ALLB of ≥30 years. The highest PAF of total stroke with ALLB ≥26 years was observed in rural-middle-SES individuals, with value of 59.15 % (95 % CI 56.80–61.48).</div></div><div><h3>Conclusion</h3><div>Later ALLB was associated with an increased risk of stroke among Chinese parous postmenopausal women, notably in lower socioeconomic rural populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112791"},"PeriodicalIF":3.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}