Experimental gerontology最新文献

{"title":"Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention","authors":"Xuan Lu ,&nbsp;Ying Chen ,&nbsp;Yue Shi ,&nbsp;Yi Shi ,&nbsp;Xianbin Su ,&nbsp;Peijie Chen ,&nbsp;Die Wu ,&nbsp;Hui Shi","doi":"10.1016/j.exger.2025.112685","DOIUrl":"10.1016/j.exger.2025.112685","url":null,"abstract":"<div><div>Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging. This review provides a comprehensive summary of different forms of exercise for older adults and the multifaceted role of exercise in anti-aging, focusing on the biological functions and sources of these exerkines. We further explore how exerkines combat aging-related diseases, such as type 2 diabetes and osteoporosis. By stimulating the secretion of these exerkines, exercise supports healthy longevity by promoting tissue homeostasis and metabolic balance. Additionally, the integration of exercise-induced exerkines into therapeutic strategies represents a promising approach to mitigating age-related pathologies at the molecular level. As our understanding deepens, it may pave the way for personalized interventions leveraging physical activity to enhance healthspan and improve quality of life.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112685"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling FOXO3's metabolic contribution to menopause and Alzheimer's disease","authors":"Christopher O'Mahony,&nbsp;Oscar Hidalgo-Lanussa,&nbsp;George E. Barreto","doi":"10.1016/j.exger.2025.112679","DOIUrl":"10.1016/j.exger.2025.112679","url":null,"abstract":"<div><div>The increasing prevalence of Alzheimer's disease (AD) calls for a comprehensive exploration of its complex etiology, with a focus on sex-specific vulnerability, particularly the heightened susceptibility observed in postmenopausal women. Neurometabolic alterations during the endocrine transition emerge as early indicators of AD pathology, including reduced glucose metabolism and increased amyloid-beta (Aβ) deposition. The fluctuating endocrine environment, marked by declining estradiol levels and reduced estrogen receptor beta (ERβ) activity, further exacerbates this process. In this context, here we explore the potential of forkhead box O3 (FOXO3) as a critical mediator linking metabolic disturbances to hormonal decline. We propose that FOXO3 plays a key role in the intersection of menopause and AD, given its dysregulation in both AD patients and postmenopausal women, modulating cellular metabolism through interactions with the AMPK/AKT/PI3K pathways. This relationship highlights the intersection between hormonal changes and increased AD susceptibility. This review aims to open a discussion on FOXO3's contribution to the metabolic dysregulation seen in menopause and its impact on the progression of AD. Understanding the functional role of FOXO3 in menopause-associated metabolic changes could lead to targeted therapeutic strategies, offering novel insights for managing for this condition.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112679"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weight-adjusted-waist index and serum anti-aging protein α-Klotho in U.S. adults: Evidence from NHANES 2007–2016","authors":"Zujun Wen ,&nbsp;Xiang Liu ,&nbsp;Tingting Zhang ,&nbsp;Junhai Zhang ,&nbsp;Zhicong Zou ,&nbsp;Shuncheng Jiang ,&nbsp;Shusi Li","doi":"10.1016/j.exger.2024.112672","DOIUrl":"10.1016/j.exger.2024.112672","url":null,"abstract":"<div><h3>Background</h3><div>As unhealthy diets have proliferated, there has been an increasing trend in the prevalence of obesity along with socioeconomic progress. WWI, mainly representing weight-independent central obesity, is a more accurate indicator of obesity than BMI and WC. Klotho is known to be one of the root causes of several age-related illnesses. There has never been any prior evidence associating WWI and serum α-Klotho levels.</div></div><div><h3>Methods</h3><div>The current cross-sectional investigation used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016. The calculation of each participant's WWI involved dividing their waist circumference in centimeters by the square root of their weight in kilograms. Using multivariable linear regression models, the association between serum Klotho concentrations and WWI was analyzed. Smoothed curve fitting was utilized to investigate the nonlinear connection. In addition, interaction tests and other subgroup analyses were carried out.</div></div><div><h3>Results</h3><div>With an average age of 57.57 ± 10.81 years, 13,172 participants were enrolled in this study, of whom 51.45 % were female. After full adjustment, each unit increase in WWI was significantly associated with a decrease in Klotho by 23.18 ng/ml [β(95%CI) = −23.18 (−31.34, −15.02)]. Moreover, we uncovered that WWI had a stronger negative correlation with Klotho than other obesity markers, such as WC, body mass index (BMI), and a body shape index (ABSI).</div></div><div><h3>Conclusions</h3><div>To sum up, weight-adjusted-waist index levels were negatively associated with serum Klotho protein concentration and showed a stronger correlation than other obesity markers. Our findings indicated that WWI may be a predictor of reduced Klotho levels, and that controlling obesity in accordance with WWI may help lower the Klotho levels.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112672"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8+","authors":"Stefano Cacciatore ,&nbsp;Riccardo Calvani ,&nbsp;Jasmine Mancini ,&nbsp;Francesca Ciciarello ,&nbsp;Vincenzo Galluzzo ,&nbsp;Matteo Tosato ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi ,&nbsp;Lookup Study Group","doi":"10.1016/j.exger.2024.112666","DOIUrl":"10.1016/j.exger.2024.112666","url":null,"abstract":"<div><h3>Background</h3><div>Poor sleep quality may contribute to sarcopenia, but evidence remains sparse. This retrospective cross-sectional study investigated the association between subjective sleep quality and probable sarcopenia in a cohort of community-dwelling older adults enrolled in the Longevity Check-Up 8+ study.</div></div><div><h3>Methods</h3><div>Participants were asked about their sleep quality over the past month, with four possible options (“very good”, “quite good”, “quite bad”, very bad”). For the analysis, participants were grouped into good or bad sleep quality categories. Probable sarcopenia was operationalized according to handgrip strength values &lt; 27 kg for men and &lt; 16 kg for women. Logistic regression models were used to explore the relationship between sleep quality and probable sarcopenia.</div></div><div><h3>Results</h3><div>1971 participants were included in the analysis (mean age 73.4 ± 6.2 years, 50.0 % women). Bad sleep quality was reported by 28.3 % of participants and was more prevalent among women, physically inactive individuals, and those with dyslipidemia. Probable sarcopenia was more prevalent in participants with bad sleep quality (23.8 % vs. 18.7 %, <em>p</em> = 0.012). Logistic regression revealed that bad sleep quality was significantly associated with increased odds of probable sarcopenia in both unadjusted (odds ratio [OR] 1.36, 95 % confidence interval [CI] 1.07–1.72, <em>p</em> = 0.010) and fully adjusted models (OR 1.40, 95 % CI 1.08–1.81, <em>p</em> = 0.011).</div></div><div><h3>Conclusions</h3><div>Poor sleep quality is associated with increased likelihood of probable sarcopenia in older adults. This finding highlights the importance of addressing sleep quality in interventions aimed at preventing sarcopenia and promoting healthy aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112666"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study","authors":"Mingyi Yang ,&nbsp;Jiale Xie ,&nbsp;Yani Su ,&nbsp;Ke Xu ,&nbsp;Pengfei Wen ,&nbsp;Xianjie Wan ,&nbsp;Hui Yu ,&nbsp;Zhi Yang ,&nbsp;Lin Liu ,&nbsp;Peng Xu","doi":"10.1016/j.exger.2025.112682","DOIUrl":"10.1016/j.exger.2025.112682","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the genetic causality for the insomnia and common orthopedic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoporosis (OP), and gout (GT).</div></div><div><h3>Methods</h3><div>The genome-wide association study (GWAS) summary data on insomnia were obtained from a published study, while the GWAS summary data on RA, AS, OP, and GT were sourced from the FinnGen consortium. We utilized the TwoSampleMR package of the R software (version 4.1.2) to conduct a two-sample Mendelian randomization (MR) analysis. Our primary method of analysis was the random-effects inverse variance weighted (IVW) approach. Subsequently, we conducted a series of sensitivity analyses for the MR analysis.</div></div><div><h3>Results</h3><div>The MR analysis revealed a positive genetic causal relationship between insomnia and RA (<em>P</em> = 0.016, odds ratio [OR] 95 % confidence interval [CI] = 1.112 [1.020–1.212]). However, no significant genetic causal relationship was observed between insomnia and AS (<em>P</em> = 0.194, OR 95 % CI = 1.121 [0.944–1.331]), OP (<em>P</em> = 0.788, OR 95 % CI = 1.016 [0.904–1.142]), and GT (<em>P</em> = 0.757, OR 95 % CI = 1.018 [0.912–1.136]). The MR analysis did not exhibit heterogeneity, horizontal pleiotropy, outlier effects, or dependence on a single SNP, and demonstrated normal distribution, which guaranteed the robustness of the results.</div></div><div><h3>Conclusion</h3><div>The results of this study suggest that insomnia may be a significant risk factor for RA, and controlling insomnia may represent a promising strategy for preventing RA. While insomnia was not observed to be associated with AS, OP, and GT at the genetic level, other levels of association cannot be excluded.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112682"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of utility of wearable sensor technologies for older person frailty assessment","authors":"Chen Yixiao ,&nbsp;Shen Hui ,&nbsp;Song Quhong ,&nbsp;Zeng Xiaoxi ,&nbsp;Yue Jirong","doi":"10.1016/j.exger.2024.112668","DOIUrl":"10.1016/j.exger.2024.112668","url":null,"abstract":"<div><div>Frailty is one of the most concerning aspects of global population aging, and early identification is crucial to prevent or reverse its progression. Simple, universal, and efficient frailty assessment technologies are essential for the timely detection of frailty in older patients. Various multi-dimensional assessment instruments have been developed to quantify frailty phenotypes; we review the literature on wearable sensor technologies leveraged for older person frailty assessment. This review examines representative studies on older person frailty assessment published up to 2024, summarizing pertinent wearable sensor technologies utilized for frailty assessment. Our findings suggest that objective, simple, rapid, and affordable sensor-based frailty screening holds utility across diverse applications including diagnostic aid, prognostication, and endpoint ascertainment in research.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112668"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Vivifrail-B multicomponent exercise program based on society ecosystems theory on physical function in community-dwelling frail older adults: A randomized controlled trial","authors":"Yue Li ,&nbsp;Shasha Li ,&nbsp;Xu Weng ,&nbsp;Xinyu Yang ,&nbsp;Jianyi Bao ,&nbsp;Shufang Liao ,&nbsp;Yingxue Xi ,&nbsp;Xiaofang Song ,&nbsp;Guojing Guo","doi":"10.1016/j.exger.2024.112670","DOIUrl":"10.1016/j.exger.2024.112670","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to explore the short and long-term effects of the Vivifrail-B multicomponent exercise based on society ecosystems theory on physical function in community-dwelling frail older adults.</div></div><div><h3>Methods</h3><div>59 older adults were randomly assigned to the intervention (<em>n</em> = 30) and control (<em>n</em> = 29) groups. The exercise was performed thrice a week for 12 weeks, with one offline group training and two at home training. The Tilburg Frailty Indicator (TFI), the Short Physical Performance Battery (SPPB), Handgrip strength (HGS), the Physical Self-Maintenance Scale (PSMS), and the Instrumental Activities of Daily Living Scale (IADL) were assessed at baseline, 6 weeks, 12 weeks, 18 weeks, and 24 weeks. Exercise compliance assessments and satisfaction surveys were conducted at post intervention. Generalized estimating equations was used to compare outcome measures.</div></div><div><h3>Results</h3><div>At T1 (6-week), SPPB (<em>P</em> = 0.040) and PSMS (<em>P</em> = 0.042) of subjects in the intervention group were statistically different from the control group. At T2 (12-week), T3 (18-week) and T4 (24-week), all variables were significantly improved compared to the control group (all, <em>P</em> &lt; 0.05), except for IADL (P_T2 = 0.181, P_T3 = 0.192, P_T4 = 0.163). The short and long-term effects of the intervention were significant compared to the baseline level. However, the differences in Psychology (<em>P</em> = 0.699) and Society (<em>P</em> = 0.644) before and after the intervention were not significant.</div></div><div><h3>Conclusion</h3><div>Vivifrail-B multicomponent exercise based on society ecosystems theory improved physical function of community-dwelling frail older adults, and the older adults' exercise compliance and satisfaction were high.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112670"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin is associated with higher cortical thickness in early Alzheimer's disease.","authors":"Yane Zheng, Huiying Gu, Yuming Kong","doi":"10.1016/j.exger.2025.112698","DOIUrl":"https://doi.org/10.1016/j.exger.2025.112698","url":null,"abstract":"<p><strong>Background: </strong>The brain is the most cholesterol-rich organ, essential for myelination and neuronal function. Statins, widely used to lower cholesterol, cross the blood-brain barrier and may impact brain cholesterol synthesis. Despite their widespread use, the effects of statins on cortical regions relevant to Alzheimer's disease (AD) are not well understood. This study aimed to compare cortical thickness between statin-exposed and statin-unexposed older adults and evaluate the potential neuroprotective effects of statins.</p><p><strong>Methods: </strong>Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The sample included 193 healthy controls (HC), 485 individuals with mild cognitive impairment (MCI), and 169 individuals with Alzheimer's disease (AD). Participants were categorized as statin users if they had used statins for at least two years. MRI data were processed using FreeSurfer software to estimate cortical thickness in 64 regions of interest. ANCOVA models assessed the association between statin use and cortical thickness at baseline, and linear mixed models evaluated longitudinal changes.</p><p><strong>Results: </strong>Statin use was associated with increased cortical thickness in multiple brain regions across HC, MCI, and AD participants. In HC, statin users had greater thickness in the right lateral occipital, left middle temporal, and left parahippocampal regions. MCI participants exhibited additional increases in the right cuneus, right posterior cingulate, and left superior temporal cortex. In AD, statin users had higher thickness in the right cuneus and right superior parietal lobule. Longitudinal analysis revealed no statin-related differences in cortical thickness changes among HC and AD groups, but in MCI, statins slowed cortical thinning in the left medial orbitofrontal cortex.</p><p><strong>Conclusion: </strong>Statin use is associated with greater cortical thickness in older adults, particularly in those with MCI. These findings suggest that statins may have neuroprotective effects, potentially mitigating neurodegenerative changes in early cognitive decline. Further research with larger cohorts and longer follow-up periods is needed to confirm these findings and understand the mechanisms involved.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112698"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of lower-limb isokinetic strength from functional fitness tests in older adults: A 550-participant cross-sectional study","authors":"Carlos Babiloni-López ,&nbsp;Pablo Jiménez-Martínez ,&nbsp;Carlos Alix-Fages ,&nbsp;Ángel Saez-Berlanga ,&nbsp;Álvaro Juesas ,&nbsp;Pedro Gargallo ,&nbsp;Javier Gene-Morales ,&nbsp;Juan C. Colado","doi":"10.1016/j.exger.2025.112683","DOIUrl":"10.1016/j.exger.2025.112683","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to explore the association and prediction of hip abduction-adduction and knee flexion-extension isokinetic absolute and relative strength and power at 60°/s and 180°/s from functional tests performance (i.e., Up-and-Go Test [seconds], 30-Second Chair Stand Test [repetitions and relative and allometric power], 30-Second Arm Curl Test [repetitions], and 6-Minute Walk Test [meters]) in older adults.</div></div><div><h3>Methods</h3><div>Five hundred and fifty participants (404 women; age: 69.12 ± 5.29 years) enrolled in this cross-sectional study. Participants attended the laboratory once. Isokinetic concentric-concentric strength was assessed before physical fitness tests. Agility and dynamic tests were completed before strength and aerobic resistance tests within the physical fitness tests.</div></div><div><h3>Results</h3><div>Significant trivial-to-moderate correlations (positive and negative) were found between all the tests and the isokinetic strength and power of the knee and the hip. The performance in the UGT and 6MWT showed the best direct correlations with isokinetic strength and power (|<em>r|</em> = 0.09–0.48), and the 30CS and 30 AC showed inconsistent positive and negative correlations (<em>r</em> = −0.46–0.44). Significant regression equations including the functional tests, age, and sex were found, with higher values for knee isokinetic strength and power (R² = 0.19–0.44) compared to hip (R² = 0.09–0.35) and no clear pattern regarding better or worse predictability at higher angular velocities.</div></div><div><h3>Conclusions</h3><div>Isokinetic knee and hip strength and power are associated with functional fitness in older adults. The functional fitness tests, along with age and sex are predictive variables of older adults' lower-limb isokinetic strength, although explaining at most 44 % of the variance.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112683"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials","authors":"Liang Ding ,&nbsp;Lijie Lou ,&nbsp;Mingyang Zhang ,&nbsp;Xing Zhang","doi":"10.1016/j.exger.2024.112652","DOIUrl":"10.1016/j.exger.2024.112652","url":null,"abstract":"<div><div>Aerobic and resistance exercises are widely recognized as essential for preserving and enhancing cognitive function. However, the effects of concurrent exercise on cognition in older adults remain unclear. This systematic review sought to evaluate the regular effects of concurrent aerobic and resistance training on global cognition in healthy older adults. A comprehensive search was conducted across PubMed, Web of Science, EMBASE, Google Scholar, Cochrane Library, and CNKI up to July 2024. Randomized controlled trials involving healthy older adults aged ≥65 years that assessed the cognitive effects of concurrent exercise were included. The methodological quality of the included studies was evaluated using the PEDro scale. Meta-analyses were performed using a random-effects model, and heterogeneity was quantified with the I² statistic. The initial search identified 13,533 records, ultimately including 12 studies in the meta-analysis, which involved 2557 participants. The meta-analysis revealed non-significant effects of concurrent exercise on global cognition (SMD = 0.12, 95 % CI: −0.08 to 0.33, <em>p</em> = 0.200). The subgroup analysis indicated that concurrent exercise cannot enhance global cognition compared to active controls (SMD = −0.03, 95 % CI: −0.23 to 0.18, <em>p</em> = 0.80), but it does show significant improvement compared to passive controls (SMD = 0.35, 95 % CI: 0.14 to 0.56, <em>p</em> &lt; 0.001). Moderate heterogeneity was observed (I² = 49.9 %), and sensitivity analyses confirmed the stability of the results. No significant publication bias was identified. While concurrent exercise was effective in improving global cognition in healthy older adults, the improvements were not superior to active control conditions. Future research should investigate optimal training combinations and sequences to maximize cognitive benefits.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112652"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}