Experimental gerontology最新文献

{"title":"Are we underestimating cardiovascular risks in midlife women? A call for gender-specific strategies","authors":"Madhan Krishnan, Shyamaladevi Babu","doi":"10.1016/j.exger.2025.112787","DOIUrl":"10.1016/j.exger.2025.112787","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112787"},"PeriodicalIF":3.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VPS33B-dependent exosomes modulate cellular senescence of mesenchymal stem cells via an autocrine signaling pathway","authors":"Hehe Wang ,&nbsp;Qi Tan ,&nbsp;Yijuan Duan ,&nbsp;Mingduo Wu ,&nbsp;Bin Zuo ,&nbsp;Jiao Li","doi":"10.1016/j.exger.2025.112786","DOIUrl":"10.1016/j.exger.2025.112786","url":null,"abstract":"<div><div>Mesenchymal stem cell (MSC)-derived exosomes have been intensively studied for their therapeutic effects on tissue repair and regeneration. However, the specific contributions of exosomes derived from endogenous bone marrow MSCs to the maintenance of bone tissue homeostasis remain unclear. In this study, we impaired MSC-derived exosome secretion by specifically deleting vascular protein sorting 33B (VPS33B). Mice deficient in VPS33B (VPS33B-cKO mice) exhibited premature bone loss and imbalanced bone remodeling processes, which were associated with a reduction in MSC number and an increase in bone marrow inflammation. MSCs derived from VPS33B-cKO mice exhibited impaired self-renewal, proliferation, osteoblastic differentiation, and increased cellular senescence. Incubation with exosomes (Y-Exo) derived from MSCs of wildtype young mice greatly ameliorated senescent phenotypes observed in VPS33B-deficient MSCs. We further demonstrated exosome autocrine pathway through a fluorescent-labeled uptake assay and observed a significant association between autocrinal exosomes and the senescence of MSCs. Mechanistically, miR-136-3p and miR-146a-5p were highly enriched in Y-Exo but not in exosomes from senescent MSCs, which promoted cell proliferation while inhibiting inflammation by targeting the PI3K-Akt and NF-κB pathway, respectively. Furthermore, intramedullary transplantation of Y-Exo successfully mitigated age-related MSC exhaustion and bone loss. Our findings indicate that endogenous MSC-derived exosomes play a crucial regulatory role in the maintenance of bone homeostasis, and propose the potential therapeutic application of young MSC-derived exosomes for the treatment of senile osteoporosis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"207 ","pages":"Article 112786"},"PeriodicalIF":3.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between diffusion MRI-based measures of neurite microstructure and risk of Alzheimer's disease","authors":"Sasha Hakhu,&nbsp;Andrew Hooyman,&nbsp;Jennapher Lingo VanGilder,&nbsp;Sydney Y. Schaefer,&nbsp;Scott C. Beeman,&nbsp;Alzheimer's Disease Neuroimaging Initiative","doi":"10.1016/j.exger.2025.112782","DOIUrl":"10.1016/j.exger.2025.112782","url":null,"abstract":"<div><div>Early detection of Alzheimer's disease (AD) is crucial for intervention, but traditional MRI and cognitive assessments may miss pre-symptomatic changes. Advanced diffusion MRI (dMRI) methods, such as Neurite Orientation Dispersion and Density Imaging (NODDI), show promise in identifying early brain changes. We analyzed 65 cognitively unimpaired older adults (25 APOE-e4 carriers, 40 non-carriers) from the ADNI3 dataset. NODDI's neurite density index (NDI) and orientation dispersion index (ODI), volumetric MRI and cognition (MoCA) were analyzed in key brain regions like the hippocampus, fusiform gyrus, and entorhinal cortex. Statistical analyses included linear regression and <em>t</em>-tests, with FDR correction. NDI differed significantly between carriers and non-carriers and correlated with MoCA scores. ODI differed only in the CA1 hippocampal subfield. Volumetric MRI measures showed no group differences. Significant APOE-e4 group differences were observed in NDI for the left fusiform gyrus (β = 0.015, p = 0.02), right fusiform gyrus (β = 0.018, p = 0.02), left entorhinal cortex (β = 0.018, p = 0.04), right entorhinal cortex (β = 0.018, p = 0.03), left CA1 (β = 0.03, p = 0.02), and left CA2–3 (β = 0.03, p = 0.02). ODI differences were observed only in left CA1 (β = 0.037, p = 0.008). No volumetric measures differed significantly. MoCA correlated with NDI in bilateral entorhinal cortices (p = 0.001–0.05), left fusiform gyrus (p = 0.02), and right CA2–3 (p = 0.02). NODDI metrics, particularly NDI, could help detect early APOE-e4-related microstructural changes, while traditional volumetric MRI measures remain uninformative at early stages.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112782"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases","authors":"Feixiang Yang ,&nbsp;Xiangyu Zhang ,&nbsp;Wei Dai ,&nbsp;Ke Xu ,&nbsp;Yunyun Mei ,&nbsp;Tianrui Liu ,&nbsp;Kun Wang ,&nbsp;Qianjun Liang ,&nbsp;Peng Guo ,&nbsp;Chaozhao Liang ,&nbsp;Jialin Meng","doi":"10.1016/j.exger.2025.112783","DOIUrl":"10.1016/j.exger.2025.112783","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia is a prevalent age-related disorder characterized by progressive loss of muscle mass, strength, and physical performance. While genome-wide association studies (GWAS) have explored isolated traits, the multifactorial genetic architecture underlying sarcopenia remains poorly defined. In this study, we constructed a comprehensive genetic factor to explain the genetic architecture of sarcopenia, and explore causal associations, genetic comorbidities, and mediating pathways linking sarcopenia to 30 urological diseases.</div></div><div><h3>Methods</h3><div>Based on the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, six sarcopenia-related phenotypes were selected. A multivariate GWAS framework using genomic structural equation modeling (genomic SEM) was constructed, with an effective sample size of 651,820 individuals. Bidirectional Mendelian randomization (MR) was employed to assess causal relationships between sarcopenia and 30 urological diseases. Genetic correlation, tissue-specific heritability enrichment, shared risk genes, and gene set enrichment analyses were conducted to dissect genetic comorbidities between sarcopenia and urological diseases. Multi-omic mediation analysis was conducted to identify potential pathways mediated by blood proteins, metabolites, and immune traits.</div></div><div><h3>Results</h3><div>Multivariate GWAS identified 215 loci and 30,869 single-nucleotide polymorphisms (SNPs) associated with polygenic architecture of sarcopenia. Bidirectional Mendelian randomization revealed causal links between sarcopenia and urological diseases, notably hyperplasia of prostate (BPH; OR = 1.17, <em>P</em> = 0.043) and acute tubulointerstitial nephritis (ATIN; OR = 1.14, <em>P</em> = 0.028). Genetic comorbidity analyses identified local genetic correlations between sarcopenia and BPH, and highlighted tissue-specific heritability enrichment in <em>Cells Cultured fibroblasts</em> tissue for both traits, while no genetic correlation was found with ATIN. We identified 75 shared risk genes for sarcopenia and BPH, which were enriched in cellular component biogenesis, RNA binding, and metabolic pathways. Multi-omic mediation analyses prioritized 17 metabolites and proteins linking sarcopenia to BPH and ATIN, though no significant immune mediators were identified.</div></div><div><h3>Conclusion</h3><div>These findings unveil a shared genetic architecture between sarcopenia and urological diseases, especially BPH, with heritability enrichment in fibroblast tissue and metabolic dysfunction emerging as the significant overlapping pathway.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112783"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of commonly used assessment methods for predicting fall risk in the elderly","authors":"Aziz DENGİZ ,&nbsp;Ahmet AYTEPE ,&nbsp;Bayram SIRRI ,&nbsp;Mehmet EFE","doi":"10.1016/j.exger.2025.112784","DOIUrl":"10.1016/j.exger.2025.112784","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to evaluate the effectiveness of four different commonly used assessment methods Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Modified Falls Efficacy Scale (MFES), and Morse Fall Scale (MFS) in predicting fall risk in elderly.</div></div><div><h3>Method</h3><div>The study included 195 participants (97 female, mean age: 69.82 ± 7.45 years) aged 60 and above. The BBS, TUG, MFES, and MFS were used to asses fall risk. Logistic regression analysis was conduct.</div></div><div><h3>Results</h3><div>The addition of independent variables significantly reduced the −2 Log Likelihood value (from 222.015 to 49.196), and the Nagelkerke R² value was 0.865. The Hosmer-Lemeshow goodness-of-fit test (<em>p</em> = .738) and ROC analysis (AUC 0.958–0.972) confirmed the model's strong fit and high discriminative power. The MFS (B = 0.120, <em>p</em> = .001, Exp(B) = 1.128) and the TUG(B = 0.542, <em>p</em> = .004, Exp(B) = 1.720) were significantly associated with fall risk. In contrast, the MFES and BBS did not show statistically significant effects.</div></div><div><h3>Conclusions</h3><div>The MFS and TUG are particularly effective in identifying fall risk in elderly individuals. However, using these tests alone may have limited predictive power, highlighting the importance of a multidisciplinary approach for fall risk assessment.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112784"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between molecular markers of biological aging and orthopedic diseases: A two-sample bidirectional Mendelian randomization study","authors":"Wei Yan ,&nbsp;Yichen Zhao ,&nbsp;Jiahui Zhang ,&nbsp;Ping Jiang ,&nbsp;Honghong Ma ,&nbsp;Min Fang ,&nbsp;Xiaobing Xi","doi":"10.1016/j.exger.2025.112785","DOIUrl":"10.1016/j.exger.2025.112785","url":null,"abstract":"<div><h3>Background</h3><div>Studies indicate an association between biological aging and orthopedic diseases, but the causality remains unclear.</div></div><div><h3>Aims</h3><div>This study aims to investigate the bidirectional causal relationship between molecular markers of biological aging age and orthopedic conditions.</div></div><div><h3>Methods</h3><div>A two-sample Mendelian randomization (MR) analysis based on a genome-wide association study (GWAS) was conducted to explore these causal relationships. Analysis methods included inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode. Sensitivity analyses involved Cochran's Q, MR-Egger, leave-one-out, and MR pleiotropy residual sum and outlier (MR-PRESSO) tests.</div></div><div><h3>Results</h3><div>The forward MR analysis identified several causal relationships: granulocyte proportions influenced intervertebral disc degeneration (IVDD) (OR 0.2316, <em>P</em> = 0.0101) and low back pain (LBP) (OR 0.2624, <em>P</em> = 0.007); telomere length (TL) affected cervical spondylosis (C/S) (OR 0.8759, <em>P</em> = 0.0167) and IVDD (OR 0.9184, <em>P</em> = 0.023); fibroblast growth factor-23 (FGF-23) impacted frozen shoulder (FS) (OR 1.2424, <em>P</em> = 0.0316); and HannumAge influenced C/S (OR 0.9518, <em>P</em> = 0.0233). The reverse MR analysis found that FS influenced TL (OR 0.9582, <em>P</em> = 0.0002) and α-Klotho (OR 0.7592, <em>P</em> = 0.0256), while sciatica affected TL (OR 0.9344, <em>P</em> = 0.0055) and C/S impacted PhenoAge (OR 1.6583, <em>P</em> = 0.0131) after outlier exclusion. Cochran's Q indicated heterogeneity in certain analyses, and MR-Egger showed no horizontal pleiotropy in significant causal associations.</div></div><div><h3>Conclusions</h3><div>This study suggests a potential causal associations between molecular markers of biological aging and orthopedic diseases, suggesting avenues for future research into the underlying mechanisms.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112785"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between METS-VF and sarcopenia among middle-aged and older adults in China: The first longitudinal evidence from CHARLS","authors":"Tong Li ,&nbsp;Yi Ren ,&nbsp;Meilan Liu ,&nbsp;Qing Wang ,&nbsp;Tianhan Sun ,&nbsp;Jianfu Cao ,&nbsp;Hongyuan Cui","doi":"10.1016/j.exger.2025.112778","DOIUrl":"10.1016/j.exger.2025.112778","url":null,"abstract":"<div><h3>Background</h3><div>The association between the Metabolic Score for Visceral Fat (METS-VF) and sarcopenia remains unclear. This study aims to explore the relationship between METS-VF and sarcopenia in the middle-aged and older adults in China.</div></div><div><h3>Methods</h3><div>Data were collected from 2011 and 2015 of the China Health and Retirement Longitudinal Survey (CHARLS) and 2948 participants were enrolled in this study. METS-VF was calculated using data from CHARLS. Sarcopenia was defined according to the criteria set by the Asian Working Group for Sarcopenia (AWGS) 2019. Potential confounders were identified through the Directed Acyclic Graph (DAG). The association between METS-VF and sarcopenia was then analyzed using multivariate logistic regression and restricted cubic spline (RCS) analysis.</div></div><div><h3>Results</h3><div>Compared with low METS-VF, high METS-VF (OR = 1.65, 95 % CI = 1.08–2.52) showed a significant association with the occurrence of sarcopenia. Subgroup and interaction analyses revealed that residence (<em>P</em> for interaction = 0.012) influenced the relationship between METS-VF and sarcopenia. Additionally, RCS analysis demonstrated a non-linear relationship between METS-VF and sarcopenia.</div></div><div><h3>Conclusions</h3><div>There is a positive non-linear correlation between METS-VF and sarcopenia with residence showing an impact on this association. Early identification of patients with possible sarcopenia by METS-VF is of great value for disease prediction, prevention, early diagnosis and timely treatment to reduce the potential disease burden.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112778"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging","authors":"Dongfeng Lan ,&nbsp;Dan Zhang ,&nbsp;Xiaofang Dai ,&nbsp;Ji Cai ,&nbsp;He Zhou ,&nbsp;Tao Song ,&nbsp;Xianyao Wang ,&nbsp;Qinghong Kong ,&nbsp;Zhengzhen Tang ,&nbsp;Jun Tan ,&nbsp;Jidong Zhang","doi":"10.1016/j.exger.2025.112781","DOIUrl":"10.1016/j.exger.2025.112781","url":null,"abstract":"<div><div>Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. Exosomes (Exos), a type of extracellular vesicles (EVs) secreted by MSCs via the paracrine pathway, play a pivotal role in conveying the biological functions of MSCs. Accumulating evidence from extensive research underscores the remarkable anti-aging potential of both MSCs and their Exos. This review comprehensively explores the impact of MSCs and their Exos on key hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, impaired macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Furthermore, this paper highlights emerging strategies and novel approaches for modulating the aging process, offering insights into potential therapeutic interventions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112781"},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triglyceride-glucose index mediates associations between dietary inflammation index/Composite Dietary Antioxidant Index and cardiovascular disease incidence: insights from NHANES study","authors":"Han Gao ,&nbsp;Bo Yan ,&nbsp;Fangyuan Cheng ,&nbsp;Shishuang Zhang ,&nbsp;Pan Liao ,&nbsp;Dai Li ,&nbsp;Lin Zhang ,&nbsp;Fanglian Chen ,&nbsp;Ping Lei","doi":"10.1016/j.exger.2025.112779","DOIUrl":"10.1016/j.exger.2025.112779","url":null,"abstract":"<div><h3>Aims</h3><div>This study investigates how Dietary Inflammatory Index (DII) and Composite Dietary Antioxidant Index (CDAI) patterns relate to cardiovascular disease, with particular focus on their metabolic connections, providing novel insights for prophylaxis and remedy.</div></div><div><h3>Methods</h3><div>Data from NHANES (2009–2014) were utilized in this retrospective cross-sectional research. Binary logistic regression and the generalized linear model (GLM) were applied to assess the correlations among DII, CDAI, metabolic factors, and CVD. Moreover, causal mediation analysis was carried out to further probe into the mediating role of the TyG-index.</div></div><div><h3>Results</h3><div>Significant positive correlations between DII (odds ratio [OR] 1.08, 95 % confidence interval [CI] 1.01–1.16, <em>p</em> = 0.036) and CVD were observed, while CDAI exhibits a nonlinear association with the risk of CVD. The combined effect analysis indicated that the group with a low DII and high CDAI combination had the least risk (OR 0.52, 95 % CI 0.35–0.78, <em>p</em> = 0.002). TyG-index was found to mediate 4.95 % of the connection between DII and CVD and 8.02 % of the linkage between CDAI and CVD, respectively.</div></div><div><h3>Conclusions</h3><div>This study manifests that DII and CDAI are respectively correlated with the risk of CVD incidence. The diet low in inflammation and rich in antioxidants can safeguard against disease occurrence. Serving as a metabolic marker, the TyG-index serves to establish the connection among DII, CDAI, and the progression of CVD.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112779"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific association of oxidative balance score with sarcopenia in American adults: NHANES 2011–2018","authors":"Xinyi Pei ,&nbsp;Di Jin ,&nbsp;Lin Liu ,&nbsp;Qingrao Song ,&nbsp;Da Pan ,&nbsp;Baofu Guo ,&nbsp;Wei Xie","doi":"10.1016/j.exger.2025.112775","DOIUrl":"10.1016/j.exger.2025.112775","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Nutritional status and levels of oxidative stress may be modifiable risk factors for the development of sarcopenia. The Oxidative Balance Score (OBS) is a comprehensive measure of oxidative balance in diet and life exposures. We conducted a cross-sectional study to investigate the association between OBS and sarcopenia in US adults.</div></div><div><h3>Methods</h3><div>Based on the 2011–2018 National Health and Nutrition Examination Survey (NHANES), this study included 3084 participants. Weighted logistic regression analysis and restricted cubic spline regression (RCS) were used to assess the association between OBS and sarcopenia, as well as gender differences in this association.</div></div><div><h3>Results</h3><div>OBS and sarcopenia are negatively associated (OR = 0.951, 0.919–0.983, <em>p</em> = 0.004). Compared with the lowest quartile of OBS, the highest quartile was significantly negatively associated with sarcopenia (OR = 0.431, 0.202–0.917, <em>p</em> for trend = 0.01). Both dietary OBS and lifestyle OBS were significantly negatively associated with sarcopenia (OR = 0.963, 0.930–0.997, <em>p</em> = 0.032; OR = 0.634, 0.562–0.715, <em>p</em> &lt; 0.001). In gender subgroup analysis, a significant negative association between OBS and sarcopenia was observed in women (OR = 0.916, 0.862–0.973, <em>p</em> = 0.005), while the association was not significant in men. The RCS showed a significant linear correlation between total population OBS, female OBS and sarcopenia (<em>p</em> for nonlinear &gt;<!--> <!-->0.05, <em>p</em> for overall &lt;0.05).</div></div><div><h3>Conclusions</h3><div>Higher oxidative balance scores are associated with a lower prevalence of sarcopenia, particularly among women. These findings support the importance of antioxidant-rich diets and healthy lifestyles in mitigating sarcopenia risk, especially in aging female populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"206 ","pages":"Article 112775"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}