Experimental gerontology最新文献

{"title":"Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly.","authors":"Mahdie Dehnavi, Najmeh Valizadeh Zare, Seyd Reza Mazlom, Samira Mohajer, Tahereh Sadeghi, Mohammad Namazinia, Danial Baghie","doi":"10.1016/j.exger.2024.112661","DOIUrl":"10.1016/j.exger.2024.112661","url":null,"abstract":"<p><strong>Background: </strong>The increasing elderly population is a complex and globally significant phenomenon impacting various sectors of society, including healthcare. By 2050, it is projected that one-fourth of Iran's population will be elderly. Falls are a major concern among the elderly, leading to physical and psychological injuries and imposing significant financial burdens on healthcare and social systems. Given the widespread acceptance of smartphones and mobile health applications, however limited research has been conducted on the effectiveness of mobile applications in training caregivers for home safety and accident prevention in elderly populations.</p><p><strong>Methods: </strong>This randomized clinical trial was conducted in 2022 in Mashhad, Iran. The sample consisted of 66 elderly caregivers, randomly assigned to intervention and control groups. Data collection tools included a demographic information questionnaire and the Home Safety Self-Assessment Tool (HSSAT). The intervention group used a home safety educational application, while the control group received educational brochures. Data were analyzed using SPSS software and appropriate statistical tests.</p><p><strong>Results: </strong>Sixty-two elderly caregivers participated in the study, with a mean age of 72 ± 37.7 years. The chi-square test showed no significant difference in gender distribution between the intervention and control groups (p = 0.060). The majority of participants in both groups had a high school education. Before the training, there was no significant difference in the mean accident risk management scores between the two groups (p = 0.713). Repeated measures ANOVA revealed a significant time effect (F(1, 60) = 408, p < 0.001, Partial η² = 0.872) and a significant group effect (F(1, 60) = 5, p = 0.025, Partial η² = 0.081). Additionally, the interaction between time and group was significant (F(1, 60) = 6, p = 0.015, Partial η² = 0.095), indicating a greater improvement in accident risk management scores in the intervention group compared to the control group.</p><p><strong>Conclusions: </strong>The use of home safety educational applications can effectively reduce the risk of accidents and improve preventive measures management among the elderly. These modern educational tools can alleviate the burden on healthcare systems and save costs associated with in-person training. Future research should continue exploring innovative educational methods to enhance the safety and well-being of the elderly population.</p><p><strong>Trial registration: </strong>This study was registered in the Iranian Registry of Clinical Trials (no. IRCT20210610051532N1) on 07/09/2021.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112661"},"PeriodicalIF":3.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice.","authors":"Nida Rasheed, Hafiza Khushbakht Hussain, Zohabia Rehman, Azka Sabir, Waseem Ashraf, Tanveer Ahmad, Faleh Alqahtani, Imran Imran","doi":"10.1016/j.exger.2024.112659","DOIUrl":"10.1016/j.exger.2024.112659","url":null,"abstract":"<p><p>Aluminum chloride (AlCl₃), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays a pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes and efficacy of CoQ10 and curcumin low dose (100 mg/kg each) combination in 18-months old geriatric male Balb/c mice subjected to AlCl₃-prompted memory derangements (200 mg/kg in water bottles) for 28 days. The neuroprotective properties driven by antioxidant mechanisms were assessed via observing cellular pathology in key-memory related brain regions including the cornuammonis (CA3 and DG) and cortex 2/3 layer. Our outcomes revealed that AlCl₃ exposure significantly reduced spatial learning and memory. In contrast, CoQ10 and curcumin combinatorial regime markedly mitigated cognitive deficits Vs. individual high-dose in AlCl₃-treated animals as demonstrated by their improved performance in neurobehavioral tests such as the Y-maze, novel object recognition, passive avoidance and Morris-water maze test. Additionally, CoQ10 and curcumin co-administration restored redox balance by significantly reducing the levels of oxidative stressor (MDA) and increasing the anti-oxidant capacity (SOD,GPx). AchE is an enzyme involved in acetylcholine breakdown which negatively impacts acetylcholine levels and memory function. AlCl₃ exposure elevated AchE levels in mice brains vs. treatment. This neurochemical alteration was notably reversed in the dual-treatment group. Furthermore, CoQ10 and curcumin ameliorated AlCl₃-induced neurotoxicity by preserving neuronal cytoarchitecture in both cortical and hippocampal regions. In conclusion, CoQ10 and curcumin combination might attenuate memory loss induced by AlCl₃-intoxication via restoring aberrant AchE activity, enhanced anti-oxidant defenses and salvaging the deleterious neuronal damage.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112659"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China.","authors":"Decheng Li, Yunhe Wang, Shuai Guo, Ziyang Ren, Binbin Su, Lichuan Zhang, Zuliyaer Talifu, Xiaoying Zheng","doi":"10.1016/j.exger.2024.112656","DOIUrl":"10.1016/j.exger.2024.112656","url":null,"abstract":"<p><strong>Background: </strong>Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.</p><p><strong>Methods: </strong>We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). IC was evaluated across cognitive, locomotion, psychological, sensory, and vitality domains. Asymmetry and weakness were measured using the maximum value of HGS. Logistic regression models were employed to examine the association of the individual and combined groupings of HGS asymmetry and weakness with IC impairment (a total score ≥ 2 across five domains). The potential non-linear relationship was explored using a restricted cubic spline (RCS) model.</p><p><strong>Results: </strong>Of the 4798 participants included (median age 66.0 years, IQR 63.0-71.0 years; 56.9 % male), 35.2 % had IC impairment. HGS asymmetry (OR = 1.26, 95 % CI: 1.11-1.43) and weakness (OR = 2.09, 95 % CI: 1.78-2.45) were both independent risk factors for IC impairment. Notably, participants experiencing both HGS asymmetry and weakness were at even higher risk of IC impairment (OR = 2.47, 95 % CI: 1.99-3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between HGS status and impairments in specific IC domains, particularly in locomotion. In contrast to other domains, it was the Weakness only group, rather than the Both group, that had the highest risk of vitality impairment. There was a U-shaped relationship between HGS asymmetry and IC impairment.</p><p><strong>Conclusions: </strong>HGS asymmetry and weakness were associated with an increased risk of composite and individual domain IC impairment. Assessing and maintaining HGS symmetry and strength may have implications for the early identification of individuals at risk for IC impairment and the prevention of related adverse health outcomes.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112656"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary phytochemicals alleviate the premature skin aging: A comprehensive review.","authors":"Harpreet Singh, Y T Kamal, Jessica Pandohee, Arun Kumar Mishra, Aritra Biswas, Sourav Mohanto, Arvind Kumar, Sagnik Nag, Amrita Mishra, Mhaveer Singh, Himanshu Gupta, Hitesh Chopra","doi":"10.1016/j.exger.2024.112660","DOIUrl":"10.1016/j.exger.2024.112660","url":null,"abstract":"<p><p>Skin aging, often called as premature skin aging, is the hastened deterioration of the skin resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency to eradicate free radicals and lowering the release of inflammatory mediators which accounts for premature skin aging. Several dietary phytochemicals, i.e., carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, etc., exhibited potential anti-oxidant, anti-inflammatory, suppression of UV damage, and promote collagen synthesis. In addition, dietary phytochemicals include sulfur, present in various foods safeguard the skin against oxidative stress and inflammation. Thus, this article delves into the comprehension of various dietary phytochemicals investigated to alleviate the premature skin aging. The article further highlights specific phytochemicals and their sources, bioavailability, mechanisms, etc., in the context of safeguarding the skin against oxidative stress and inflammation. The present manuscript is a systematic comprehension of the available literature on dietary phytochemicals and skin aging in various database, i.e., PubMed, ScienceDirect, Google Scholar using the keywords, i.e., \"dietary phytochemicals\", \"nutraceuticals\", \"skin aging\" etc., via Boolean operator, i.e., \"AND\". The dietary guidelines presented in the manuscript is a unique summarization for a broad reader to understand the inclusion of various functional foods, nutrients, supplements, etc., to prevent premature skin aging. Thus, the utilization of dietary phytochemicals has shown a promising avenue in preventing skin aging, however, the future perspectives and challenges of such phytochemicals should be comprehended via clinical investigations.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112660"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure.","authors":"Kengo Yoshida, Zhenqiu Liu, Yoshiko Kubo, Masahiko Miura, Mika Yamaoka, Hiroko Nagamura, Munechika Misumi, Yoichiro Kusunoki","doi":"10.1016/j.exger.2024.112646","DOIUrl":"10.1016/j.exger.2024.112646","url":null,"abstract":"<p><p>The T cell aging process can be modified by genotoxic factors, including ionizing radiation, and metabolic controls, such as caloric restriction; the former accelerates and the latter retards the process. However, the mechanisms by which these systemic factors interact to cause T cell aging remain unclear. This study investigated the naïve T-cell pool, thymic cellularity, and transcriptome in mice irradiated with 3.8 Gy at 5 weeks of age and treated 13 months later with 30 mM spermidine (SPD), a metabolism regulator. The number of conventional naïve CD4 and CD8 T cells in the peripheral blood decreased 14 months after irradiation whereas the number of virtual memory naïve T cells, which increased with age, further increased by irradiation. However, these radiation-related changes were not significant in similarly irradiated mice that were subsequently treated with SPD. The numbers of total, double-positive, and single-positive thymocytes were decreased by irradiation, whereas none were decreased in the irradiated mice treated with SPD. RNA sequencing of thymus cells revealed 803 upregulated genes in irradiated mice compared with those in non-irradiated control mice, with these genes enriched in leukocyte activation and inflammatory cytokine production. However, only 22 genes were upregulated in irradiated and SPD-treated mice, suggesting a reversal of many radiation-induced gene expression changes. These findings suggest that SPD may alleviate radiation-induced acceleration of T-cell aging, particularly by mitigating reduced thymopoiesis and inflammation. Further research is warranted to explore the rejuvenating potential of SPD and its mechanisms of action in accelerated T-cell aging.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112646"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor.","authors":"Xin Xu, Hui Yu, Mingyi Yang, Jiale Xie, Ke Xu, Erliang Li, Xianjie Wan, Jiachen Wang, Guoqiang Wang, Ying Pan, Peng Xu, Junfei Guo","doi":"10.1016/j.exger.2024.112657","DOIUrl":"10.1016/j.exger.2024.112657","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) and obstructive sleep apnea (OSA) are prevalent chronic conditions with emerging evidence suggesting a potential link. However, the causality of this association remains unclear, possibly influenced by confounders like high body mass index (BMI). This study aimed to explore causal relationships between OA and OSA using Mendelian randomization (MR).</p><p><strong>Methods: </strong>MR analysis was performed to assess causality between OA and OSA. Inverse variance weighting (IVW) was the primary MR method, complemented by sensitivity analyses, including MR steiger, MR-Egger, MR-PRESSO, weighted median, heterogeneity tests, and leave-one-out approaches to evaluate pleiotropy and confirm the robustness of the causal estimates. To exclude confounding effects of BMI, we also used a multivariate MR (MVMR).</p><p><strong>Results: </strong>After adjusting for BMI through MVMR, no significant causal relationship was identified between genetically predicted OSA and OA phenotypes, including knee (KOA) and hip osteoarthritis (HOA), suggesting that obesity largely drives the observed relationship between these conditions. Similarly, MR steiger doesn't support a causal effect from OA on OSA. Sensitivity analyses confirmed the robustness of these results, with no significant evidence of horizontal pleiotropy or heterogeneity affecting outcomes. The findings indicate that BMI acts as a critical confounder in the relationship between OSA and OA, rather than OSA directly contributing to OA development.</p><p><strong>Conclusions: </strong>Our findings indicate that there is no significant causal relationship between genetically predicted OSA and OA after adjusting for BMI. These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. Future research should aim to validate these findings in diverse populations and explore other metabolic pathways that may contribute to these complex associations.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112657"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma volume variations in response to high intensity interval training in obese women: The influential role of menopausal status and age.","authors":"Georges Jabbour, Maha Sellami, Horia-Daniel Iancu","doi":"10.1016/j.exger.2024.112664","DOIUrl":"https://doi.org/10.1016/j.exger.2024.112664","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the effects of high-intensity interval training (HIIT) on plasma volume (PV) variations in obese women, with a focus on understanding how menopausal status and age influence these changes.</p><p><strong>Methods: </strong>We enrolled fifty-nine obese women (perimenopausal and postmenopausal), aged approximately 56.6 years in a six-week HIIT program. Measurements of fitness, health, and PV were taken before and after the intervention. PV was assessed at two points during each session: at post-warm-up (PV1), and immediately post-training (PV2). These measurements were derived using hematocrit (Ht) and hemoglobin (Hb) values.</p><p><strong>Results: </strong>The intervention led to notable reductions in anthropometric measures and blood pressure (P < 0.01). For all women pre- and post-HIIT comparisons revealed significant differences in the extent of PV reduction at all two points (P < 0.01). Multiple linear regression analysis revealed that age was a significant contributor to the decreases in plasma volume (PV) observed both after warm-up and following the supramaximal cycling test - SCT (r = 0.44 and r = 0.57). On the other hand, menopause status was an independent predictor for PV decreases after warm-up (r = 0.33) as well after SCT (r = 0.38). Following HIIT, only menopause status accounted for 19 % of the variation in PV decreases after warm-up and 21 % of the variation in PV decreases after SCT.</p><p><strong>Conclusions: </strong>The findings suggest that HIIT is effective in enhancing plasma volume among obese menopausal women, attenuating the age-related decline in PV.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112664"},"PeriodicalIF":3.9,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials.","authors":"Farhad Gholami, Javad Mesrabadi, Mohadeseh Iranpour, Adel Donyaei","doi":"10.1016/j.exger.2024.112658","DOIUrl":"10.1016/j.exger.2024.112658","url":null,"abstract":"<p><p>This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3-4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes. REGISTRATION NUMBER: CRD42024499195.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112658"},"PeriodicalIF":3.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive analysis of sarcopenia markers in young adults with down syndrome.","authors":"Brett S Nickerson, Michael R Esco, George Schaefer, Elroy J Aguiar, Stefan A Czerwinski","doi":"10.1016/j.exger.2024.112655","DOIUrl":"10.1016/j.exger.2024.112655","url":null,"abstract":"<p><strong>Background: </strong>Most body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.</p><p><strong>Objective: </strong>This brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.</p><p><strong>Methods: </strong>Fourteen young adults (age = 26 ± 9 yrs.) with DS (males: n = 6; females: n = 8) had appendicular skeletal muscle mass (ASM) measured with bioimpedance analysis and handgrip strength (HGS) measured with a hand dynamometer (dominant hand). Sarcopenia was computed using the European Working Group on Sarcopenia in Older People revised definition (EWGSOP2).</p><p><strong>Results: </strong>The BMI for the entire group was 24.41 ± 4.01 kg/m², ranging from 16.21 to 31.31 kg/m², with one participant classified as obese. ASM ranged from 11.33 to 24.41 kg (17.49 ± 4.71 kg), and 64 % of participants fell below the EWGSOP2 criteria for muscle mass. HGS ranged from 8 to 31 kg (20 ± 7 kg), and 57 % of participants fell below the EWGSOP2 criteria for muscular strength. Lastly, 5 of 14 participants (approximately 36 %) had sarcopenia according to the EWGSOP2 definition.</p><p><strong>Conclusion: </strong>An alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112655"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing fracture risk indication: The impact of bone load index and muscle fat infiltration on vertebral compression fracture.","authors":"Xiao-Yue Jiang, Zhi-Yang Tang, Bo-Wen Liu, Si-Yuan Lu, Dong-Gang Pan, Hui Jiang, Xiu-Hong Shan","doi":"10.1016/j.exger.2024.112654","DOIUrl":"10.1016/j.exger.2024.112654","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify risk factors for vertebral compression fracture and enhance the ability to indicate fracture risk.</p><p><strong>Methods: </strong>A retrospective collection of clinical and imaging data was conducted for patients with vertebral compression fractures and control subjects who underwent quantitative computed tomography scans. Stepwise logistic regression analysis was employed to identify variables associated with fractures, constructing both unadjusted model and adjusted model.</p><p><strong>Results: </strong>Compared with the non-fracture group, the fracture group showed significant differences in weight, body mass index (BMI), bone mineral density (BMD), vertebral cross-sectional area, paraspinal muscle area and right psoas major muscle fat area (all P < 0.05). Adjusted characteristics analyzed by stepwise logistic regression indicated that bone load index (BLI) (OR = 3.19, P = 0.041), paraspinal muscle fat infiltration (PMFI) (OR = 2.27, P = 0.039), and right psoas major muscle fat infiltration (RPMFI) (OR = 1.08, P = 0.005) were independent risk factors for vertebral fractures. Interaction analysis revealed a positive interaction between BLI and PMFI (OR = 1.95, P = 0.008) as well as RPMFI (OR = 1.53, P = 0.045). Compared with the unadjusted model, the diagnostic performance of the adjusted model was significantly improved (training set IDI: 19.5 %, validation set IDI: 18.4 %, P < 0.001). Correlation analysis demonstrated significant associations between BMD (r = -0.353, P = 0.002), BLI (r = 0.631, P < 0.001), PMFI (r = 0.412, P < 0.001), RPMFI (r = 0.513, P < 0.001), and the degree of vertebral compression.</p><p><strong>Conclusion: </strong>Under conditions of bone maladaptive loading and muscle degeneration, vertebral bodies may become more susceptible to external forces, increasing the risk of vertebral compression fracture.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112654"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}