{"title":"婚姻状况的性别差异和年龄加速的风险：NHANES 2015-2018的调查结果。","authors":"Jialu Wang, Feixiang Xu, Yin Wang, Lizhan Bie","doi":"10.1016/j.exger.2025.112912","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging. Our study aimed to investigate the association between marital status and the risk of age acceleration, as well as exploring whether there were gender differences in this association.</p><p><strong>Methods: </strong>This cross-sectional study involved 3202 participants from four National Health and Nutrition Examination Survey (NHANES) cycles between 2015-2018. Marital status was collected via a questionnaire. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated by performing a linear regression of PhenoAge against chronological age.</p><p><strong>Results: </strong>The multivariable logistic regression model showed that, compared to individuals who were married or living with a partner, those who were widowed, divorced or separated were associated with a 35 % reduced risk of PhenoAgeAccel development (OR: 0.65, 95 % CI: 0.49-0.87), while those who had never been married had a 1.79-fold increased risk of PhenoAgeAccel development (OR: 1.79, 95 % CI: 1.33-2.40). Of these, individuals who were married or living with a partner, or who were widowed, divorced or separated, and who did not have depression, had a lower risk of aging compared with people who were married or living with a partner and who had depression (OR: 0.61, 95 % CI: 0.38-0.98; OR:0.41, 95 % CI: 0.23-0.73, respectively). Gender disparity analyses indicated that never being married increased the risk of PhenoAgeAccel in men (OR: 2.45, 95 % CI: 1.69-3.56) while it decreased the risk in women (OR: 0.56, 95 % CI: 0.39-0.81) (P for interaction = 0.013).</p><p><strong>Conclusions: </strong>The findings of this cross-sectional study suggested that differential marital status has a variable impact on the risk of developing age acceleration, with significant gender differences. All indications are that men benefit more from marriage in the aging process, which is food for thought.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112912"},"PeriodicalIF":4.3000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gender disparities in marital status and risk of developing age acceleration: Findings from NHANES 2015-2018.\",\"authors\":\"Jialu Wang, Feixiang Xu, Yin Wang, Lizhan Bie\",\"doi\":\"10.1016/j.exger.2025.112912\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging. Our study aimed to investigate the association between marital status and the risk of age acceleration, as well as exploring whether there were gender differences in this association.</p><p><strong>Methods: </strong>This cross-sectional study involved 3202 participants from four National Health and Nutrition Examination Survey (NHANES) cycles between 2015-2018. Marital status was collected via a questionnaire. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated by performing a linear regression of PhenoAge against chronological age.</p><p><strong>Results: </strong>The multivariable logistic regression model showed that, compared to individuals who were married or living with a partner, those who were widowed, divorced or separated were associated with a 35 % reduced risk of PhenoAgeAccel development (OR: 0.65, 95 % CI: 0.49-0.87), while those who had never been married had a 1.79-fold increased risk of PhenoAgeAccel development (OR: 1.79, 95 % CI: 1.33-2.40). Of these, individuals who were married or living with a partner, or who were widowed, divorced or separated, and who did not have depression, had a lower risk of aging compared with people who were married or living with a partner and who had depression (OR: 0.61, 95 % CI: 0.38-0.98; OR:0.41, 95 % CI: 0.23-0.73, respectively). Gender disparity analyses indicated that never being married increased the risk of PhenoAgeAccel in men (OR: 2.45, 95 % CI: 1.69-3.56) while it decreased the risk in women (OR: 0.56, 95 % CI: 0.39-0.81) (P for interaction = 0.013).</p><p><strong>Conclusions: </strong>The findings of this cross-sectional study suggested that differential marital status has a variable impact on the risk of developing age acceleration, with significant gender differences. All indications are that men benefit more from marriage in the aging process, which is food for thought.</p>\",\"PeriodicalId\":94003,\"journal\":{\"name\":\"Experimental gerontology\",\"volume\":\" \",\"pages\":\"112912\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental gerontology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.exger.2025.112912\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental gerontology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.exger.2025.112912","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gender disparities in marital status and risk of developing age acceleration: Findings from NHANES 2015-2018.
Background: Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging. Our study aimed to investigate the association between marital status and the risk of age acceleration, as well as exploring whether there were gender differences in this association.
Methods: This cross-sectional study involved 3202 participants from four National Health and Nutrition Examination Survey (NHANES) cycles between 2015-2018. Marital status was collected via a questionnaire. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated by performing a linear regression of PhenoAge against chronological age.
Results: The multivariable logistic regression model showed that, compared to individuals who were married or living with a partner, those who were widowed, divorced or separated were associated with a 35 % reduced risk of PhenoAgeAccel development (OR: 0.65, 95 % CI: 0.49-0.87), while those who had never been married had a 1.79-fold increased risk of PhenoAgeAccel development (OR: 1.79, 95 % CI: 1.33-2.40). Of these, individuals who were married or living with a partner, or who were widowed, divorced or separated, and who did not have depression, had a lower risk of aging compared with people who were married or living with a partner and who had depression (OR: 0.61, 95 % CI: 0.38-0.98; OR:0.41, 95 % CI: 0.23-0.73, respectively). Gender disparity analyses indicated that never being married increased the risk of PhenoAgeAccel in men (OR: 2.45, 95 % CI: 1.69-3.56) while it decreased the risk in women (OR: 0.56, 95 % CI: 0.39-0.81) (P for interaction = 0.013).
Conclusions: The findings of this cross-sectional study suggested that differential marital status has a variable impact on the risk of developing age acceleration, with significant gender differences. All indications are that men benefit more from marriage in the aging process, which is food for thought.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
