Dynamic changes in nutritional status and sleep disturbance in Parkinson's disease.

Purpose: This study aims to investigate the relationship between dynamic changes in nutritional status and sleep disturbance in patients with Parkinson's disease (PD).

Methods: This study included 209 PD patients with regular follow-ups from January 2021 to January 2023. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Data on nutritional indicators, including albumin, hemoglobin, total protein, cholesterol, triglyceride, LDL cholesterol, prealbumin, transferrin, NEFA, and retinol-binding protein (RBP), were collected at both admission and discharge. Patients were categorized into groups based on changes in albumin levels, and the relationship between nutritional status and sleep disturbance was analyzed.

Results: The study found that 27.75 % of patients experienced malnutrition, while 48.33 % had sleep disturbance. Before treatment, BMI, MDS-UPDRS, albumin, hemoglobin, total protein, cholesterol, triglyceride, transferrin, NEFA, and RBP were positively associated with sleep disturbance (r = 5.012, 6.821, 3.291, 0.782, 0.674, 0.813, 0.938, 0.531, 0.763, 0.362, P < 0.001); age, LDL cholesterol, and prealbumin were negatively correlated (r = -2.182, -2.187, -9.761, P < 0.001). Multivariate logistic regression analysis identified prealbumin as a significant risk factor for sleep disturbance (OR: 1.384, 95 % CI: 1.062-1.883, P < 0.05).

Conclusions: The study concluded that nutritional status, particularly levels of albumin and prealbumin, is closely related to the occurrence of sleep disturbance in PD patients.