Gender disparities in marital status and risk of developing age acceleration: Findings from NHANES 2015-2018.

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Experimental gerontology Pub Date : 2025-10-01 DOI:10.1016/j.exger.2025.112912

Jialu Wang, Feixiang Xu, Yin Wang, Lizhan Bie

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引用次数: 0

Abstract

Background: Marriage has been a hot topic since ancient times forever, yet there is little research evidence on marital status as an important socio-behavioral factor in relation to aging. Our study aimed to investigate the association between marital status and the risk of age acceleration, as well as exploring whether there were gender differences in this association.

Methods: This cross-sectional study involved 3202 participants from four National Health and Nutrition Examination Survey (NHANES) cycles between 2015-2018. Marital status was collected via a questionnaire. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated by performing a linear regression of PhenoAge against chronological age.

Results: The multivariable logistic regression model showed that, compared to individuals who were married or living with a partner, those who were widowed, divorced or separated were associated with a 35 % reduced risk of PhenoAgeAccel development (OR: 0.65, 95 % CI: 0.49-0.87), while those who had never been married had a 1.79-fold increased risk of PhenoAgeAccel development (OR: 1.79, 95 % CI: 1.33-2.40). Of these, individuals who were married or living with a partner, or who were widowed, divorced or separated, and who did not have depression, had a lower risk of aging compared with people who were married or living with a partner and who had depression (OR: 0.61, 95 % CI: 0.38-0.98; OR:0.41, 95 % CI: 0.23-0.73, respectively). Gender disparity analyses indicated that never being married increased the risk of PhenoAgeAccel in men (OR: 2.45, 95 % CI: 1.69-3.56) while it decreased the risk in women (OR: 0.56, 95 % CI: 0.39-0.81) (P for interaction = 0.013).

Conclusions: The findings of this cross-sectional study suggested that differential marital status has a variable impact on the risk of developing age acceleration, with significant gender differences. All indications are that men benefit more from marriage in the aging process, which is food for thought.

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婚姻状况的性别差异和年龄加速的风险：NHANES 2015-2018的调查结果。

背景：婚姻自古以来就是一个热门话题，但很少有研究表明婚姻状况是与衰老相关的重要社会行为因素。本研究旨在探讨婚姻状况与年龄加速风险之间的关系，并探讨这种关系是否存在性别差异。方法：本横断面研究涉及2015年至2018年四个国家健康与营养检查调查（NHANES）周期的3202名参与者。通过问卷调查收集婚姻状况。表型年龄加速（PhenoAgeAccel）是通过对表型年龄对实足年龄进行线性回归来计算的。结果：多变量logistic回归模型显示，与已婚或与伴侣同居的个体相比，丧偶、离婚或分居的个体表型加速发展风险降低35 % (or: 0.65, 95 % CI: 0.49-0.87)，而从未结婚的个体表型加速发展风险增加1.79倍（or: 1.79, 95 % CI: 1.33-2.40）。其中，已婚或与伴侣同住、丧偶、离婚或分居、没有抑郁症的人，与已婚或与伴侣同住并患有抑郁症的人相比，衰老的风险较低（or: 0.61, 95 % CI: 0.38-0.98; or:0.41, 95 % CI: 0.23-0.73）。性别差异分析表明，从未结婚会增加男性患PhenoAgeAccel的风险（OR: 2.45, 95 % CI: 1.69-3.56），而降低女性患PhenoAgeAccel的风险（OR: 0.56, 95 % CI: 0.39-0.81）（P为相互作用 = 0.013）。结论：本横断面研究发现，不同的婚姻状况对年龄加速发生的风险有不同的影响，且性别差异显著。所有迹象都表明，随着年龄的增长，男性从婚姻中获益更多，这是值得思考的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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