Experimental gerontology最新文献

{"title":"Corrigendum to “TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence” [Experimental Gerontology Volume 195 (2024) 1-8 /112546]","authors":"Limeiting Wang , Jun Zhang , Lu Liang , Zijun Song , Pinwen Wang , Liya Ma , Zhenhui Liao , Ning Li , Hefeng Yang , Song Li","doi":"10.1016/j.exger.2024.112653","DOIUrl":"10.1016/j.exger.2024.112653","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112653"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary phytochemicals alleviate the premature skin aging: A comprehensive review","authors":"Harpreet Singh ,&nbsp;Y.T. Kamal ,&nbsp;Jessica Pandohee ,&nbsp;Arun Kumar Mishra ,&nbsp;Aritra Biswas ,&nbsp;Sourav Mohanto ,&nbsp;Arvind Kumar ,&nbsp;Sagnik Nag ,&nbsp;Amrita Mishra ,&nbsp;Mhaveer Singh ,&nbsp;Himanshu Gupta ,&nbsp;Hitesh Chopra","doi":"10.1016/j.exger.2024.112660","DOIUrl":"10.1016/j.exger.2024.112660","url":null,"abstract":"<div><div>Skin aging, often called as premature skin aging, is the hastened deterioration of the skin resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, <em>etc.</em> Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency to eradicate free radicals and lowering the release of inflammatory mediators which accounts for premature skin aging. Several dietary phytochemicals, <em>i.e.</em>, carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, <em>etc.</em>, exhibited potential anti-oxidant, anti-inflammatory, suppression of UV damage, and promote collagen synthesis. In addition, dietary phytochemicals include sulfur, present in various foods safeguard the skin against oxidative stress and inflammation. Thus, this article delves into the comprehension of various dietary phytochemicals investigated to alleviate the premature skin aging. The article further highlights specific phytochemicals and their sources, bioavailability, mechanisms, <em>etc.</em>, in the context of safeguarding the skin against oxidative stress and inflammation. The present manuscript is a systematic comprehension of the available literature on dietary phytochemicals and skin aging in various database, <em>i.e.</em>, PubMed, ScienceDirect, Google Scholar using the keywords, <em>i.e.</em>, “dietary phytochemicals”, “nutraceuticals”, “skin aging” <em>etc.</em>, <em>via</em> Boolean operator, <em>i.e.</em>, “AND”. The dietary guidelines presented in the manuscript is a unique summarization for a broad reader to understand the inclusion of various functional foods, nutrients, supplements, <em>etc.</em>, to prevent premature skin aging. Thus, the utilization of dietary phytochemicals has shown a promising avenue in preventing skin aging, however, the future perspectives and challenges of such phytochemicals should be comprehended <em>via</em> clinical investigations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112660"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action observation with motor simulation of reactive stepping: A randomized study in older adults with a history of falls","authors":"Lotte Hagedoorn ,&nbsp;Aurora Ruiz-Rodríguez ,&nbsp;Ilse Leijen ,&nbsp;Edwin van Asseldonk ,&nbsp;Vivian Weerdesteyn","doi":"10.1016/j.exger.2024.112645","DOIUrl":"10.1016/j.exger.2024.112645","url":null,"abstract":"<div><h3>Background</h3><div>Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated whether action observation with motor simulation (AOMS) of balance recovery improves reactive stepping in older adults with a history of falls. Additionally, we evaluated whether effects differ between AOMS of a human actor in the same experimental context or of an avatar in a virtual world.</div></div><div><h3>Methods</h3><div>Seventy participants with a history of falls (68.3 ± 5.2y/o;52f) were subjected to 20 balance perturbations eliciting backward reactive steps. The AOMS group was tested after simulation of 20 reactive steps demonstrated by either a human actor (HumanAOMS) or a virtual avatar (AvatarAOMS). The control group was tested without prior observation. The primary outcome was reactive step quality, quantified as the leg angle at stepping-foot contact.</div></div><div><h3>Results</h3><div>Differences between groups in the first perturbation trial were not significant. Upon repeated trials, both AOMS groups improved reactive step quality substantially faster than the control group. AOMS participants required on average five repetitions to achieve a reactive step quality that was no longer different from final performance in the last trial, whereas the control group needed ten. Both HumanAOMS and AvatarAOMS yielded similar gains.</div></div><div><h3>Conclusions</h3><div>The lack of effect in the first trial suggests that AOMS alone may not be sufficient for preventing real-life falls in this population. A next step would be to investigate whether this could be achieved by combining brief real perturbation practice with AOMS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112645"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the synergistic potential of herbal medicine and dietary supplements for treating postmenopausal osteoporosis","authors":"Jinfang Dou ,&nbsp;Xuehong Hu ,&nbsp;Junchang Liu ,&nbsp;Jiaxian Liu ,&nbsp;Chuyue Zhang ,&nbsp;Yuelin Zhang ,&nbsp;Xianjie Zhen ,&nbsp;Siyu Tao ,&nbsp;Jinghua Zhang ,&nbsp;Guangjian Jiang","doi":"10.1016/j.exger.2024.112648","DOIUrl":"10.1016/j.exger.2024.112648","url":null,"abstract":"<div><h3>Purpose</h3><div>The exploration of the combined effects of FLL and quinoa presents an intriguing opportunity to enhance the efficacy of osteoporosis treatment.</div></div><div><h3>Methods</h3><div>This study aimed to predict the potential anti-osteoporotic effects of FLL and quinoa using network pharmacology and subsequently verify these predictions through experimental investigation. Thirty rats were divided into five groups: sham operation group (SO), ovariectomized group (OVX), FLL group (FLL), quinoa group (Quinoa), and FLL combined with quinoa group (F&amp;Q). The 12-week experiment involved measurements of bone density and microstructure, histological evaluation of femoral trabeculae and bone cortex, quantification of osteoclasts in the femur, assessment of osteoclast differentiation factor expression (NFATc1 and C-Fos), and measurement of collagen I carboxyl-terminal peptide (CTX-1). Additionally, intestinal flora analysis was performed.</div></div><div><h3>Results</h3><div>The results demonstrated reduced bone mineral density, compromised bone microarchitecture, increased osteoclast numbers and differentiation, and enhanced bone resorption in the OVX group, which were completely ameliorated by FLL, quinoa and F&amp;Q interventions. F&amp;Q exhibited superior improvement in bone density and microarchitecture compared to FLL and quinoa, although no significant differences were observed in their effects on osteoclasts and bone resorption. Gut flora analysis revealed that F&amp;Q was more effective than FLL and quinoa in alleviating OVX-induced intestinal flora disorders, particularly in terms of enhancing intestinal flora diversity and function.</div></div><div><h3>Conclusion</h3><div>The combo of FLL and quinoa was more effective in treating ovariectomy-induced osteoporosis and gut flora dysbiosis than FLL alone.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112648"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise training alters resting brain-derived neurotrophic factor concentration in older adults: A systematic review with meta-analysis of randomized-controlled trials","authors":"Farhad Gholami ,&nbsp;Javad Mesrabadi ,&nbsp;Mohadeseh Iranpour ,&nbsp;Adel Donyaei","doi":"10.1016/j.exger.2024.112658","DOIUrl":"10.1016/j.exger.2024.112658","url":null,"abstract":"<div><div>This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3–4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes.</div></div><div><h3>Registration number</h3><div>CRD42024499195.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112658"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shadow puppetry therapy enhances dementia-related cognitive function and interpersonal relationship","authors":"Shu-Yuan Chao ,&nbsp;Hsiao-Mei Chen ,&nbsp;Bei-Yi Su","doi":"10.1016/j.exger.2024.112667","DOIUrl":"10.1016/j.exger.2024.112667","url":null,"abstract":"<div><h3>Background</h3><div>With the growing demand for dementia care, non-pharmacological interventions, such as creative arts therapies, have been proven effective in stabilizing cognitive function. Shadow Puppetry Therapy (SPT), which integrates visual, auditory, and kinesthetic elements, offers a promising care option for individuals with dementia.</div></div><div><h3>Objective</h3><div>This study evaluated the effectiveness of SPT on cognitive function, self-esteem, and interpersonal relationships among older adults with mild dementia.</div></div><div><h3>Methods</h3><div>We adopted a quasi-experimental design and recruited 33 older adults with mild dementia from two dementia care centers. Older adults with mild dementia were randomly assigned to an experimental group (<em>n</em> = 15) and a control group (<em>n</em> = 18). The experimental group participated in a 16-week SPT program, and the control group engaged in regular activities, such as physical exercises, painting, cooking, music, and handicraft projects. Assessments included the short portable mental status questionnaire (SPMSQ), the Rosenberg self-esteem scale (RSES), and the interpersonal relationship scale, with evaluations conducted before and after the intervention.</div></div><div><h3>Results</h3><div>The intervention significantly improved cognitive function, self-esteem, and interpersonal relationships in the experimental group. SPMSQ scores decreased, indicating enhanced cognitive function (<em>p</em> = .001), while self-esteem and interpersonal relationship scores showed significant improvements (<em>p</em> = .001). No significant changes were observed in the control group.</div></div><div><h3>Conclusion</h3><div>SPT is an effective non-pharmacological intervention for enhancing cognitive function, self-esteem, and interpersonal relationships in older adults with mild dementia. The findings support the integration of creative arts therapies into dementia care.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112667"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for the special issue on “microbiomes in extremes of aging”","authors":"Hariom Yadav ,&nbsp;Varsha D. Badal ,&nbsp;Michal M. Masternak ,&nbsp;Christiaan Leeuwenburgh","doi":"10.1016/j.exger.2024.112663","DOIUrl":"10.1016/j.exger.2024.112663","url":null,"abstract":"<div><div>This special issue of the <em>Journal of Experimental Gerontology</em> explores the dynamic interplay between microbiomes and aging-related conditions. The four selected studies highlight the role of microbiota in Alzheimer's disease, cancer immunotherapy, myocardial infarction and tryptophan metabolism, providing insights into how microbiomes influence health and disease in aging. These studies underscore the potential for microbiome-targeted interventions to mitigate aging-related disorders and improve the quality of life for older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112663"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure","authors":"Kengo Yoshida ,&nbsp;Zhenqiu Liu ,&nbsp;Yoshiko Kubo ,&nbsp;Masahiko Miura ,&nbsp;Mika Yamaoka ,&nbsp;Hiroko Nagamura ,&nbsp;Munechika Misumi ,&nbsp;Yoichiro Kusunoki","doi":"10.1016/j.exger.2024.112646","DOIUrl":"10.1016/j.exger.2024.112646","url":null,"abstract":"<div><div>The T cell aging process can be modified by genotoxic factors, including ionizing radiation, and metabolic controls, such as caloric restriction; the former accelerates and the latter retards the process. However, the mechanisms by which these systemic factors interact to cause T cell aging remain unclear. This study investigated the naïve T-cell pool, thymic cellularity, and transcriptome in mice irradiated with 3.8 Gy at 5 weeks of age and treated 13 months later with 30 mM spermidine (SPD), a metabolism regulator. The number of conventional naïve CD4 and CD8 T cells in the peripheral blood decreased 14 months after irradiation whereas the number of virtual memory naïve T cells, which increased with age, further increased by irradiation. However, these radiation-related changes were not significant in similarly irradiated mice that were subsequently treated with SPD. The numbers of total, double-positive, and single-positive thymocytes were decreased by irradiation, whereas none were decreased in the irradiated mice treated with SPD. RNA sequencing of thymus cells revealed 803 upregulated genes in irradiated mice compared with those in non-irradiated control mice, with these genes enriched in leukocyte activation and inflammatory cytokine production. However, only 22 genes were upregulated in irradiated and SPD-treated mice, suggesting a reversal of many radiation-induced gene expression changes. These findings suggest that SPD may alleviate radiation-induced acceleration of T-cell aging, particularly by mitigating reduced thymopoiesis and inflammation. Further research is warranted to explore the rejuvenating potential of SPD and its mechanisms of action in accelerated T-cell aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112646"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly","authors":"Mahdie Dehnavi ,&nbsp;Najmeh Valizadeh zare ,&nbsp;Seyd Reza Mazlom ,&nbsp;Samira Mohajer ,&nbsp;Tahereh Sadeghi ,&nbsp;Mohammad Namazinia ,&nbsp;Danial Baghie","doi":"10.1016/j.exger.2024.112661","DOIUrl":"10.1016/j.exger.2024.112661","url":null,"abstract":"<div><h3>Background</h3><div>The increasing elderly population is a complex and globally significant phenomenon impacting various sectors of society, including healthcare. By 2050, it is projected that one-fourth of Iran's population will be elderly. Falls are a major concern among the elderly, leading to physical and psychological injuries and imposing significant financial burdens on healthcare and social systems. Given the widespread acceptance of smartphones and mobile health applications, however limited research has been conducted on the effectiveness of mobile applications in training caregivers for home safety and accident prevention in elderly populations.</div></div><div><h3>Methods</h3><div>This randomized clinical trial was conducted in 2022 in Mashhad, Iran. The sample consisted of 66 elderly caregivers, randomly assigned to intervention and control groups. Data collection tools included a demographic information questionnaire and the Home Safety Self-Assessment Tool (HSSAT). The intervention group used a home safety educational application, while the control group received educational brochures. Data were analyzed using SPSS software and appropriate statistical tests.</div></div><div><h3>Results</h3><div>Sixty-two elderly caregivers participated in the study, with a mean age of 72 ± 37.7 years. The chi-square test showed no significant difference in gender distribution between the intervention and control groups (<em>p</em> = 0.060). The majority of participants in both groups had a high school education. Before the training, there was no significant difference in the mean accident risk management scores between the two groups (<em>p</em> = 0.713). Repeated measures ANOVA revealed a significant time effect (F(1, 60) = 408, <em>p</em> &lt; 0.001, Partial η² = 0.872) and a significant group effect (F(1, 60) = 5, <em>p</em> = 0.025, Partial η² = 0.081). Additionally, the interaction between time and group was significant (F(1, 60) = 6, <em>p</em> = 0.015, Partial η² = 0.095), indicating a greater improvement in accident risk management scores in the intervention group compared to the control group.</div></div><div><h3>Conclusions</h3><div>The use of home safety educational applications can effectively reduce the risk of accidents and improve preventive measures management among the elderly. These modern educational tools can alleviate the burden on healthcare systems and save costs associated with in-person training. Future research should continue exploring innovative educational methods to enhance the safety and well-being of the elderly population.</div></div><div><h3>Trial registration</h3><div>This study was registered in the Iranian Registry of Clinical Trials (no. IRCT20210610051532N1) on 07/09/2021.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112661"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower extremity muscle hypertrophy in response to resistance training in older adults: Systematic review, meta-analysis, and meta-regression of randomized controlled trials","authors":"Davi Alves de Santana ,&nbsp;Pedro Godoi Scolfaro ,&nbsp;Emanuele Marzetti ,&nbsp;Cláudia Regina Cavaglieri","doi":"10.1016/j.exger.2024.112639","DOIUrl":"10.1016/j.exger.2024.112639","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the effects of resistance training (RT) on knee extensor muscle hypertrophy in adults 65 years and older.</div></div><div><h3>Methods</h3><div>A systematic search was carried out in PubMed, Embase, and Scopus to review randomized controlled trials that assessed the effects of supervised RT on 1) muscle size, 2) fiber area, and 3) leg lean mass (LLM). Random-effects meta-analyses of standardized mean difference (SMD) and raw mean difference (RMD) for LLM were calculated. We performed a meta-regression to examine the interference of age, training volume, and duration on the results related to hypertrophy at muscle and fiber levels.</div></div><div><h3>Results</h3><div>Thirty-two studies were included in the review, and 28 were meta-analyzed. The meta-analysis found a significant effect of RT on muscle size (SMD = 0.34; 95 % CI: 0.16–0.52; <em>p</em> &lt; 0.001) and fiber area (SMD = 0.54; 95 % CI: 0.24–0.84; <em>p</em> &lt; 0.001), but not on LLM (RMD = 0.22; 95 % CI: −0.22-0.66 <em>p</em> = 0.321<em>). A</em> subanalysis of studies that assessed quadriceps femoris size (excluding isolated quadriceps femoris muscles from the analysis) also revealed a significant effect of RT (95 % CI: 0.20–0.69; <em>p</em> <em>&lt;</em> <em>0.001)</em>. Regression analysis indicated a significant influence of intervention duration on type II fiber area (<em>p</em> <em>=</em> <em>0.034),</em> while no significant influence was detected for weekly sets or age for any outcome measure.</div></div><div><h3>Conclusions</h3><div>RT promotes muscle hypertrophy in older adults at both whole-muscle and fiber levels, with training duration potentially influencing the response. Measures of leg lean mass may not capture RT-induced adaptation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112639"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}