Experimental gerontology最新文献

{"title":"Machine learning insights on activities of daily living disorders in Chinese older adults","authors":"Huanting Zhang ,&nbsp;Wenhao Zhou ,&nbsp;Jianan He ,&nbsp;Xingyou Liu ,&nbsp;Jie Shen","doi":"10.1016/j.exger.2024.112641","DOIUrl":"10.1016/j.exger.2024.112641","url":null,"abstract":"<div><h3>Objective</h3><div>This study on the aged population in China first used a large-scale longitudinal survey database to explore how different life factors affect their ability to engage in daily activities. We select and integrate multiple machine models to obtain an excellent model for analyzing relationships. Based on the identified factors, our goal is to help them maintain a good daily life and quality of life.</div></div><div><h3>Method</h3><div>We analyzed data from 13,220 older individuals participating in the China Longitudinal Health Longevity Survey (CLHLS) from 2002 to 2018. ADL was measured based on participants' self-reported results. Nine machine learning algorithms, including neural networks and an ensemble model, were employed with a 2/3 training and 1/3 testing split. Model performance was evaluated using the area under the curve (AUC), sensitivity, and specificity, while logistic regression assessed the relationship between lifestyle changes and ADL disorders.</div></div><div><h3>Result</h3><div>The K-nearest neighbors (KNN) and decision tree algorithms showed the best performance, with AUCs of 0.8598 and 0.8322, respectively. Combining results from all models improved the AUC to 0.8619. Activities, such as playing mahjong, engaging in outdoor work, and reducing TV time, were linked to lower ADL decline, with greater participation in social activities and pet care also being beneficial.</div></div><div><h3>Conclusion</h3><div>Machine learning algorithms, especially ensemble models, can effectively identify older adults at risk for ADL disorders. Increased outdoor activity, social engagement, and dietary adjustments are associated with a decreased risk of ADL deterioration.</div></div><div><h3>Translational significance</h3><div><ul><li><span>1)</span><span><div>The primary question addressed by this study is: What modifiable risk factors can impact Activities of Daily Living (ADL) in older adults?</div></span></li><li><span>2)</span><span><div>The main finding of this study is that specific daily activities, such as playing mahjong and engaging in outdoor activities, significantly reduce the risk of future ADL disorders in older adults. Additionally, a robust predictive model was developed using longitudinal data from 13,220 individuals, improving the accuracy of ADL disorder risk predictions.</div></span></li><li><span>3)</span><span><div>The meaning of the finding is that incorporating behavioral interventions into community care strategies can effectively enhance the well-being of older adults by minimizing their risk of ADL dysfunction.</div></span></li></ul></div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112641"},"PeriodicalIF":3.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of plasma suPAR, sTNFR1, and sTNFR2 levels in risk stratification and outcome prediction of complicated acute kidney injury in elderly patients with coronavirus disease 2019","authors":"Fang Li ,&nbsp;Xue Tian ,&nbsp;Lu Wang ,&nbsp;Ling-Pei Wu ,&nbsp;Xiao Liu ,&nbsp;Hong-Ying Peng","doi":"10.1016/j.exger.2024.112634","DOIUrl":"10.1016/j.exger.2024.112634","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;The aim of this study is to investigate the early prognostic efficacy of plasma soluble urokinase-type plasminogen activator receptor (suPAR), soluble tumor necrosis factor receptor 1 (sTNFR1), and soluble tumor necrosis factor receptor 2 (sTNFR2) in complicated acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19), and to analyze the relevant factors contributing to complicated AKI in these patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Patients with COVID-19 hospitalized at the Affiliated Baiyun Hospital of Guizhou Medical University from March 2022 to March 2024 were selected as study participants. A total of 589 patients met the inclusion and exclusion criteria, 68 patients complicated with AKI were classified as AKI group, and the remaining 521 cases were divided into proportion sampling method and randomly selected 200 samples, which were classified as non-AKI group. Additionally, 50 healthy controls were enrolled as the control group. Logistic regression analysis was conducted to identify the relevant factors associated with complicated AKI in patients with COVID-19. Receiver operating characteristic (ROC) curves were plotted to evaluate the prognostic efficacy of plasma suPAR, sTNFR1, and sTNFR2 indicators for complicated AKI in patients with COVID-19.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among the patients with COVID-19 in the AKI group, 43 were males (63.20 %), with a median age of 79.00 (interquartile range: 75.00, 83.00) years, while the non-AKI group comprised 83 males (41.50 %), with a median age of 73.00 (interquartile range: 60.00, 80.75) years. Comparison of the sex and age between the two groups indicated that males and elderly patients had increased risks of complicated AKI (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Plasma levels of suPAR, sTNFR1, and sTNFR2 in the AKI group were significantly higher than those in the non-AKI group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Logistic regression analysis indicated that suPAR and sTNFR2 were independent factors influencing complicated AKI in patients with COVID-19 (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). The ROC curve for a single indicator showed that suPAR had the highest prognostic efficacy for complicated AKI, with an area under the curve (AUC) of 0.813, a sensitivity of 79.4 %, and a specificity of 74.0 %. The combined use of suPAR and sTNFR2 for risk assessment yielded the highest AUC of 0.838, with a sensitivity of 66.2 % and a specificity of 87.5 %. The combined risk assessment using all three indicators (suPAR, sTNFR1, and sTNFR2) had an AUC of 0.837, with a sensitivity of 64.7 % and a specificity of 89.0 %.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Elderly patients had increased risks of complicated AKI. Indicators such as suPAR, sTNFR1, and sTNFR2 can assist in assessing the risk in patients with COVID-19 complicated AKI, with suPAR demonstrating the highest prognostic efficacy as a single indicator. The combined detection of suPAR, sTNFR1, and sTNFR2 offers greater prognos","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112634"},"PeriodicalIF":3.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of physical exercise on Irisin and BDNF concentrations, and their relationship with cardiometabolic and mental health of individuals with Metabolic Syndrome: A Systematic Review","authors":"Wilder Villamil-Parra ,&nbsp;Luisa Moscoso-Loaiza","doi":"10.1016/j.exger.2024.112640","DOIUrl":"10.1016/j.exger.2024.112640","url":null,"abstract":"<div><div>Chronic Non-Communicable Diseases (NCDs), including cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes, are the leading global causes of mortality, accounting for 71 % of deaths annually. Metabolic Syndrome (MS), characterized by hypertension, obesity, insulin resistance, and dyslipidemia, is a significant risk factor for NCDs. Physical inactivity exacerbates these conditions, contributing to poor cardiovascular and mental health outcomes.</div></div><div><h3>Objective</h3><div>To analyze the effects of physical exercise on Irisin and Brain-Derived Neurotrophic Factor (BDNF) concentrations and their relationship with cardiometabolic and mental health of individuals with MS.</div></div><div><h3>Methods</h3><div>A systematic review was conducted of articles published between August 2023 and June 2024 in ScienceDirect, PubMed, and SciELO, following PRISMA guidelines. Inclusion criteria encompassed observational studies, clinical trials, and reviews with high methodological quality. The review focused on Irisin, BDNF, physical exercise, and MS.</div></div><div><h3>Results</h3><div>A total of 584 articles were identified, with 43 selected for detailed analysis. The review highlights that physical exercise significantly impacts Irisin and BDNF levels, which in turn influence metabolic and mental health. Irisin, a myokine secreted during exercise, promotes the conversion of white adipose tissue to brown adipose tissue, enhancing energy expenditure and metabolic health. Elevated Irisin levels are associated with improved cognitive function and mental well-being. BDNF, a neurotrophin, supports neuronal growth and cognitive function. Exercise-induced increases in BDNF levels are linked to enhanced neuroplasticity, reduced anxiety, and improved mood.</div></div><div><h3>Conclusion</h3><div>Understanding the role of Irisin and BDNF in response to physical exercise offers valuable insights for developing strategies to manage and prevent MS and its related mental health issues. Further research is needed to elucidate the molecular mechanisms involved.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112640"},"PeriodicalIF":3.9,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognition of mild cognitive impairment in older adults using a polynomial regression model based on prefrontal cortex hemoglobin oxygenation","authors":"Mao Tso-Yen ,&nbsp;Huang Chun-Feng ,&nbsp;Lo Hong-Wa ,&nbsp;Liu Ying-Fang ,&nbsp;Hsu Wei-Hsun ,&nbsp;Hwang Shinn-Jang","doi":"10.1016/j.exger.2024.112637","DOIUrl":"10.1016/j.exger.2024.112637","url":null,"abstract":"<div><h3>Aim</h3><div>This study employed a three-minute game-based intelligence test (GBIT) to create a hemoglobin polynomial regression model for early identification of mild cognitive impairment (MCI) in older adults.</div></div><div><h3>Methods</h3><div>210 older adult participants were recruited from community centers in the central region of Taichung City. Working memory (WM) performance in older adults was assessed during GBIT, while hemoglobin responses were measured by near-infrared spectroscopy (NIRS). Variables included oxyhemoglobin (O₂Hb) and deoxyhemoglobin (HHb). Data sequences underwent a fitting procedure using a transformed cubic polynomial function. The transformed coefficients were used as predictors of a logistic regression model to recognize MCI in older adults.</div></div><div><h3>Results</h3><div>This study confirmed the relationship between age and cognitive performance. The findings demonstrate that the NIRS cubic polynomial function trends during the GBIT test showed significant changes in older adults, increasing with age. Logistic regression analysis identified age and the orientation (coefficient <em>a</em>) of HHb as the main factors for recognizing MCI. The model achieved an overall precision of 83.33 % (sensitivity = 75.00 %; specificity = 84.68 %) with the formula: ln (Odds [<em>MCI</em>]) = −1.64 + 0.57 × <em>HHb_a</em> + 1.40 × <em>age</em>.</div></div><div><h3>Conclusions</h3><div>NIRS hemoglobin response characteristics during GBIT may serve as an efficient indicator of MCI in older adults. These findings may advance the field of cognitive health evaluation, resulting in earlier detection of cognitive deterioration in older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112637"},"PeriodicalIF":3.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and diagnostic modeling of osteoporosis and comorbidities across demographic factors: A cross-sectional study of 2224 female patients","authors":"Li Dingpeng ,&nbsp;Bai Bihui ,&nbsp;Xie Ruixuan ,&nbsp;Yao Fei ,&nbsp;Xie Xingwen ,&nbsp;Lin Demin","doi":"10.1016/j.exger.2024.112638","DOIUrl":"10.1016/j.exger.2024.112638","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the distribution of osteoporosis (OP) and its associated comorbidities across different demographic factors. Furthermore, this study seeks to develop a statistically-based diagnostic model leveraging demographic and health indicators to provide personalized risk assessments for OP.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on the demographic data, health profiles, and bone density measurements of 2224 female patients. Key variables associated with OP were identified using chi-square tests. Feature selection was refined through Lasso regression and recursive feature elimination (RFE), which guided the development of a logistic regression-based dynamic nomogram. This model was subsequently implemented on the Shiny platform for personalized online OP risk assessments.</div></div><div><h3>Results</h3><div>Among 2224 female patients, 801 (36.0 %) were diagnosed with OP. Women aged 70 and older exhibited a significantly higher prevalence of OP compared to younger age groups (OR = 5.83, 95 % CI: 1.74–19.61, <em>P</em> = 0.004), and this remained significant in the multivariable analysis (OR = 5.18, 95 % CI: 1.19–22.52, <em>P</em> = 0.028). Later age at menarche was associated with increased OP risk (OR = 1.31, 95 % CI: 1.09–1.57, <em>P</em> = 0.004), persisting in multivariable analysis (OR = 1.25, 95 % CI: 1.03–1.52, <em>P</em> = 0.023). In rheumatoid arthritis (RA) patients, higher education reduced OP risk, with secondary education (OR = 0.09, <em>P</em> = 0.024) and college education (OR = 0.04, <em>P</em> = 0.009) showing protective effects. Diabetic patients who were unmarried or had non-traditional marital statuses showed increased OP risk (univariate OR = 2.73, <em>P</em> = 0.006; multivariate OR = 2.34, <em>P</em> = 0.029). Among nonalcoholic fatty liver disease (NAFLD) patients, age at menopause was significantly linked to OP risk (univariate OR = 1.04, <em>P</em> = 0.012). The prediction model showed strong performance (AUC = 0.720), and the dynamic nomogram on the Shiny platform provided effective personalized OP risk assessments.</div></div><div><h3>Conclusion</h3><div>Age and age at menarche are significant risk factors for OP, with later menarche increasing the risk. In RA patients, higher education levels were associated with a lower risk of OP. In contrast, unmarried or non-traditional marital statuses increased OP risk among diabetic patients. Additionally, age at menopause was found to be a significant factor for OP risk in NAFLD patients. The prediction model developed in this study, with an AUC of 0.720, provides a reliable method for personalized OP risk assessment through a dynamic nomogram. These findings highlight the crucial role of demographic factors in predicting OP risk and underscore the importance of personalized treatment strategies for effective OP prevention and management.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112638"},"PeriodicalIF":3.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific in the relationship between diastolic blood pressure and the risk of cardiovascular disease: A cohort study of the UK Biobank","authors":"Fang-Fei You ,&nbsp;Wen-Fang Zhong ,&nbsp;Yi-Ning Gao ,&nbsp;Dong Shen ,&nbsp;Zhi-Hao Li ,&nbsp;Jiao-Jiao Ren ,&nbsp;Jian Gao ,&nbsp;Xiao-Meng Wang ,&nbsp;Wei-Qi Song ,&nbsp;Chuan Li ,&nbsp;Huan Chen ,&nbsp;Jia-Hao Xie ,&nbsp;Hao-Yu Yan ,&nbsp;Chen Mao","doi":"10.1016/j.exger.2024.112635","DOIUrl":"10.1016/j.exger.2024.112635","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the effect of optimal diastolic blood pressure (DBP) level on cardiovascular disease (CVD) events, considering different age groups. And the nonlinear relationship between DBP and CVD events by age were evaluated.</div></div><div><h3>Methods</h3><div>358,734 participants of the UK biobank were included. Multivariable Cox regressions were performed to evaluate the relation between DBP and cardiovascular risk, and the natural cubic spline was applied to estimate the nonlinear relationship between the DBP measures and the hazard.</div></div><div><h3>Results</h3><div>In the UK Biobank, a total of 358,734 participants (mean [SD] age, 55.3 [8.1] years; 205,215 [57.2 %] female) were included in this analysis. The rate of CVD cases was 6.05 per 1000 person-years. For each SD increase, DBP was associated with elevated CVD events for both &lt;50 year (HR, 1.19; 95 % CI, 1.12 to 1.26) and 50–59 year-old group (HR, 1.04; 95 % CI, 1.01 to 1.08). However, for every SD increment, a marginal protective effect against CVD events was observed between DBP and the CVD events in elder people (≥60 years old) and lower DBP (&lt;70 mm Hg) may confer an increased CVD risks (HR, 1.10; 95 % CI, 1.03 to 1.17).</div></div><div><h3>Conclusions</h3><div>For adults younger than 60 years old, the study seems to support the ACC/AHA blood pressure guidelines lowering the DBP threshold to 80 mm Hg. Conversely, it may be reasonable to rule out large effects of high DBP on CVD events and DBP &lt;70 mm Hg may be cause for caution in older people aged 60–69.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112635"},"PeriodicalIF":3.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life exercise impacts physiology and lifespan in a sex- and genotype-dependent manner in a Drosophila melanogaster exercise model","authors":"Heidi M. Johnson,&nbsp;Nicole C. Riddle","doi":"10.1016/j.exger.2024.112630","DOIUrl":"10.1016/j.exger.2024.112630","url":null,"abstract":"<div><div>Exercise is a common strategy for disease prevention or management, including for diabetes and cardiac dysfunction. However, exercise response varies immensely between individuals, and in humans, the same exercise treatment can lead both to positive and negative responses. <em>Drosophila melanogaster</em> is an established model for exercise research that can be leveraged to understand this variation in exercise response. Here, we investigated how two early life exercise treatments differing in duration (5 and 20 days) impact the animals' health- and lifespan in four genotypes. Specifically, we measured lifespan, activity level, body condition, physical ability, and reproductive output in this exploratory study to gain insights into potential trade-offs. For most measures, we found both immediate and long-term effects, with some effects persisting weeks past the cessation of exercise. The effect of the exercise treatment was context-dependent, with treatment, sex, and genotype interactions determining phenotypes. For example, the 20-day treatment did not exhibit a consistently larger effect than the 5-day treatment. Similarly, neither the 5-day nor the 20-day treatment impacted lifespan, but two specific genotype/sex combinations showed altered lifespan after exercise. The 20-day treatment decreased climbing performance compared to controls up to several weeks after treatment ended in some genotypes. Together, our results highlight the complex, interacting factors controlling exercise response and demonstrate that early life exercise can have long-lasting effects in the Drosophila exercise model even though most individual groups show no response.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112630"},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics","authors":"Junqi Yang ,&nbsp;Yumin Ma ,&nbsp;Jiang Liu ,&nbsp;Qingtian Zhu ,&nbsp;Rui Zhou ,&nbsp;Chenchen Yuan ,&nbsp;Yanbing Ding ,&nbsp;Weiming Xiao ,&nbsp;Weijuan Gong ,&nbsp;Qing Shan ,&nbsp;Guotao Lu ,&nbsp;Hongwei Xu","doi":"10.1016/j.exger.2024.112633","DOIUrl":"10.1016/j.exger.2024.112633","url":null,"abstract":"<div><div>The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cells' high-throughput sequencing data from the GEO public database. Utilizing bioinformatics techniques, we identified the key regulatory factor YY1 in the aging process of pancreatic islets. We observed a significant decrease in the expression of YY1 in a D-gal-induced mouse model of pancreatic aging and an H₂O₂-induced MIN6 cell model of aging. Moreover, both vivo and vitro models, we found that the YY1 agonist eudesmin (EDN) improved glucose intolerance in mice, alleviated aging of pancreatic beta cells, and downregulated the expression of cell cycle protein P21. Mechanistically, we discovered that EDN inhibited the P38/JNK MAPK pathway in aging cells. In summary, our study confirms the regulatory role of the transcription factor YY1 in the aging process of pancreatic beta cells. This finding may provide a new approach for the clinical treatment of pancreatic aging-related diseases such as impaired glucose tolerance or diabetes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112633"},"PeriodicalIF":3.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of MiR-143-3p in swimming exercise protection against osteoarthritis in mice","authors":"Jun Zhao,&nbsp;Yayi Xia,&nbsp;Jinwen He","doi":"10.1016/j.exger.2024.112632","DOIUrl":"10.1016/j.exger.2024.112632","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of swimming exercise on cartilage, inflammatory markers, subchondral bone structure, and stride length in mice with knee osteoarthritis induced by anterior cruciate ligament (ACL) transection, and to explore the role of miR-143-3p in these effects.</div></div><div><h3>Methods</h3><div>Thirty-six 3-month-old male C57BL/6 mice were randomly divided into three groups: control, exercise (swimming 30 min daily for one month), and exercise + miR-143-3p mimics (swimming exercise plus intra-articular injection of miR-143-3p mimics lentivirus once every two weeks for four weeks). Experimental groups underwent ACL transection to induce osteoarthritis. Interventions began two weeks post-modeling. Post-intervention, stride length analysis, histological analysis (including assessment of cartilage morphology and chondrocyte number), and micro-CT scanning (to assess subchondral bone structure) were performed. Inflammatory markers were measured in cartilage.</div></div><div><h3>Results</h3><div>Swimming exercise partially alleviated joint inflammation (as evidenced by reduced levels of IL-1β), protected cartilage (maintaining chondrocyte number and extracellular matrix homeostasis, as demonstrated by improved cartilage morphology), and enhanced subchondral bone structure. However, miR-143-3p supplementation partially inhibited these beneficial effects of swimming exercise. Both exercise groups showed gait impairment (reduced stride length) compared to controls, with no significant difference between the two exercise groups.</div></div><div><h3>Conclusion</h3><div>Swimming exercise can mitigate osteoarthritis progression by protecting cartilage, improving subchondral bone structure, and reducing inflammation. However, miR-143-3p partially counteracts these protective effects.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112632"},"PeriodicalIF":3.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of Life's Essentials 8 on sarcopenia prevalence among adults in the United States","authors":"Genshan Zhang ,&nbsp;Jie Fu ,&nbsp;Haokun Zhang ,&nbsp;Xiangshang Xu ,&nbsp;Zhixin Cao","doi":"10.1016/j.exger.2024.112631","DOIUrl":"10.1016/j.exger.2024.112631","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is closely associated with cardiovascular disease. We aimed to examine the association of Life's Essential 8 (LE8), the recently updated measurement of cardiovascular health (CVH), with the presence of sarcopenia among US adults.</div></div><div><h3>Methods</h3><div>This population-based cross-sectional study used data from the National Health and Nutrition Examination Survey in 2005–2006 and 2011–2018, and included adults aged 20 years or older. LE8 score was measured according to American Heart Association definitions. Sarcopenia was measured according to the National Institutes of Health definition, the ratio of appendicular skeletal muscle mass (ASM) to body mass index (BMI). Multivariable logistic and restricted cubic spline models were used to assess the associations between LE8 and sarcopenia.</div></div><div><h3>Results</h3><div>Among the 11,078 participants, 1021 (9.22 %) were diagnosed with sarcopenia. After adjusting for potential confounders, higher LE8, health behavior and health factors scores were associated with reduced odds ratios (OR) of sarcopenia (OR for per 10 scores increase in LE8, 0.65; 95 % CI 0.61–0.70; OR for per 10 scores increase in health behaviors score, 0.90; 95 % CI 0.84–0.97; OR for per 10 scores increase in health factors score, 0.67; 95 % CI 0.63–0.71). A non-linear dose-response relationship was observed between LE8 scores, health factors scores, and sarcopenia. The inversed association between LE8 score and sarcopenia was significantly stronger among males and participants with a high school education or above.</div></div><div><h3>Conclusions</h3><div>LE8 was negatively associated with the prevalence of sarcopenia in a nonlinear fashion. Promoting adherence to optimal CVH levels may benefit to reduce the risk of sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112631"},"PeriodicalIF":3.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}