Experimental gerontology最新文献

{"title":"Differences in power and performance during sit-to-stand test and its relationships to functional measures in older adults with and without Parkinson's disease","authors":"Ivan Baltasar-Fernandez ,&nbsp;Rosalia Parrino ,&nbsp;Keri Strand ,&nbsp;Joseph F. Signorile","doi":"10.1016/j.exger.2024.112542","DOIUrl":"10.1016/j.exger.2024.112542","url":null,"abstract":"<div><h3>Aims</h3><p>i) to compare 30-s sit-to-stand (STS) test repetitions and power between older adults with and without Parkinson's disease (PD) and ii) to evaluate the relationship of STS repetitions and power with functional measures in older people with PD.</p></div><div><h3>Methods</h3><p>STS repetitions and power (Alcazar's equation) during the 30-s STS test were assessed in forty-six age- and sex-matched older adults with and without PD. Functional measures included habitual (HGS) and maximum gait speed (MGS), timed-up-and-go (TUG) test and the Mini-Balance Evaluation System Test (Mini-BEST). PD-specific tests were as follows: the motor subscale of the Unified Parkinson's Disease Rating Scale (UPDRS-III), quality of life [Parkinson's Disease Questionnaire (PDQ-39)], perceived freezing of gait (FOG questionnaire), and fear of falling [Falls Efficacy Scale (FES)]. T scores, repeated measures ANOVA and linear regression analyses were used.</p></div><div><h3>Results</h3><p>T scores for older adults with PD were − 2.7 ± 4.5 for STS repetitions, −5.2 ± 4.2 for absolute STS power, and − 3.1 ± 4.6 for relative STS power compared to older adults without PD. T scores for absolute STS power were lower than T scores for STS repetitions (<em>p</em> &lt; 0.001) and relative STS power (<em>p</em> &lt; 0.001). Both absolute and relative STS power and STS repetitions showed similar correlations with functional measures (<em>r</em> = 0.44 to 0.59; both <em>p</em> &lt; 0.05). Relative STS power (<em>r</em> = −0.55; <em>p</em> &lt; 0.05) and STS repetitions (<em>r</em> = −0.47 to −0.55; <em>p</em> &lt; 0.05) but not absolute STS power were correlated to PD-specific tests.</p></div><div><h3>Conclusions</h3><p>STS repetitions and power values estimated through the 30-s STS test were lower in older people with PD than without PD. Overall, STS power measures were similarly associated with functional performance as STS repetitions, indicating these power equations can be implemented when assessing lower extremity function in older people with PD.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112542"},"PeriodicalIF":3.9,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001888/pdfft?md5=36875ae592d7f38c397037815e231bb8&pid=1-s2.0-S0531556524001888-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Aerobic exercise alleviates skeletal muscle aging in male rats by inhibiting apoptosis via regulation of the Trx system” [Exp. Gerontol. 194 (2024) 112523]","authors":"Fenmiao Bao ,&nbsp;Xiaoqin Zhao ,&nbsp;Jiaqi You ,&nbsp;Yiyao Liu ,&nbsp;Zheng Xu ,&nbsp;Yuqing Wu ,&nbsp;Yufeng Wu ,&nbsp;Zujie Xu ,&nbsp;Liang Yu ,&nbsp;Junping Li ,&nbsp;Yan Wei","doi":"10.1016/j.exger.2024.112541","DOIUrl":"10.1016/j.exger.2024.112541","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112541"},"PeriodicalIF":3.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001876/pdfft?md5=a357c67b98d24e98721db8e67ef048b8&pid=1-s2.0-S0531556524001876-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frailty and main work during the LIFE: A cross-sectional analysis of the UK Biobank","authors":"Nicola Veronese ,&nbsp;Laura Maniscalco ,&nbsp;Domenica Matranga ,&nbsp;Ligia J. Dominguez ,&nbsp;Mario Barbagallo","doi":"10.1016/j.exger.2024.112548","DOIUrl":"10.1016/j.exger.2024.112548","url":null,"abstract":"<div><h3>Background</h3><p>The role of main work during the life course in predicting frailty, a typical geriatric syndrome, is still largely unknown. Therefore, with this research, we aimed to investigate the potential association between the main work done during the life with frailty and pre-frailty among participants 60 years and older of the UK Biobank study.</p></div><div><h3>Methods</h3><p>Frailty and pre-frailty presence were ascertained using a model including 5 indicators (weakness, slowness, weight loss, low physical activity, and exhaustion); the main employment status was ascertained using self-reported information. The association between frailty and main work was explored using an ordinal logistic regression model and reported as odds ratios (ORs) with their 95 % confidence intervals (CIs).</p></div><div><h3>Results</h3><p>The final sample comprised a total of 50,447 individuals (mean age: 64.2 years, females: 50.2 %). Individuals with higher qualifications had a reduced risk of frailty (OR = 0.881, 95%CI = 0.83–0.95, <em>p</em>-value&lt;0.001 for pre-frail and OR = 0.681, 95%CI = 0.63–0.73, p-value&lt;0.001 for frail) compared to those with lower qualifications. Moreover, active participation in the workforce, compared to being inactive, emerged as a protective factor from frailty (OR = 0.753, 95%CI = 0.70–0.81, <em>p</em>-value&lt;0.001). The categories of Associate Professional and Technical Occupations exhibited protective effects against both pre-frailty and frailty. Similarly, occupations categorized as Professional and Management demonstrated protective effects against pre-frailty and frailty when compared to Elementary Occupations. Additionally, engagement in Trades and Services occupations, as opposed to Elementary Occupations, appeared to be protective against frailty.</p></div><div><h3>Conclusions</h3><p>In this large cross-sectional investigation based on the data of the UK Biobank we found that work during lifetime could be an important factor in determining frailty later in life.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112548"},"PeriodicalIF":3.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001943/pdfft?md5=bf3a584f483d2b876603709ca1984799&pid=1-s2.0-S0531556524001943-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tau pathology mediated the plasma biomarkers and cognitive function in patients with mild cognitive impairment","authors":"Lu Zhao,&nbsp;Qi Qiu,&nbsp;Shaowei Zhang,&nbsp;Feng Yan,&nbsp;Xia Li","doi":"10.1016/j.exger.2024.112535","DOIUrl":"10.1016/j.exger.2024.112535","url":null,"abstract":"<div><p>Glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are putative non-amyloid biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. Hence, this study aimed to demonstrate the relationship between plasma biomarkers (GFAP and NfL) and ¹⁸F-AV-1451 tau PET images, and to explore their effects on cognitive function. Ninety-one participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database and 20 participants from the Shanghai Action of Prevention Dementia for the Elderly (SHAPE) cohort underwent plasma biomarker testing, ¹⁸F-AV-1451 tau PET scans and cognitive function assessments. Within the ADNI, there were 42 cognitively normal (CN) individuals and 49 with mild cognitive impairment (MCI). Similarly, in the SHAPE, we had 10 CN and 10 MCI participants. We calculated the standardized uptake value ratios (SUVRs) for the regions of interest (ROIs) in the ¹⁸F-AV-1451 PET scans. Using plasma biomarkers and regional SUVRs, we trained machine learning models to differentiate between MCI and CN subjects with ADNI database and validated in SHAPE.</p><p>Results showed that eight selected variables (including left amygdala SUVR, right amygdala SUVR, left entorhinal cortex SUVR, age, education, plasma NfL, plasma GFAP, plasma GFAP/ NfL) identified by LASSO could differentiate between the MCI and CN individuals, with AUC ranging from 0.783 to 0.926. Additionally, cognitive function was negatively associated with the plasma biomarkers and tau deposition in amygdala and left entorhinal cortex. Increased tau deposition in amygdala and left entorhinal cortex were related to increased plasma biomarkers. Moreover, tau pathology mediated the effect of plasma biomarkers level on the cognitive decline. The present study provides valuable insights into the association among plasma markers (GFAP and NfL), regional tau deposition and cognitive function. This study reports the mediation effect of brain regions tau deposition on the plasma biomarkers level and cognitive function, indicating the significance of tau pathology in the MCI patients.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112535"},"PeriodicalIF":3.9,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001773/pdfft?md5=fdc9027bb2ba98a4494449e584743294&pid=1-s2.0-S0531556524001773-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cytokine receptor-like factor 1 (CRLF1) in facet joint osteoarthritis pathogenesis","authors":"Pengfei Xue ,&nbsp;Huricha Jin ,&nbsp;Xiaogang Zhou ,&nbsp;Zhiming Cui ,&nbsp;Daoran Cui","doi":"10.1016/j.exger.2024.112543","DOIUrl":"10.1016/j.exger.2024.112543","url":null,"abstract":"<div><h3>Background</h3><p>Facet joint osteoarthritis (FJOA) is a prevalent condition contributing to low back pain, particularly in the elderly population. This study aimed to investigate the potential role of Cytokine Receptor-like Factor 1 (CRLF1) in FJOA pathogenesis and its therapeutic implications.</p></div><div><h3>Methods</h3><p>Bioinformatics analysis was utilized to identify CRLF1 as the target gene, followed by quantification of CRLF1 expression levels and joint degeneration degree using immunohistochemistry (IHC). In primary chondrocytes, the inhibition of CRLF1 expression by siRNA was performed, and Western blot analysis was conducted to evaluate the involvement of the extracellular matrix and MAPK/ERK signaling pathway. Flow cytometry was employed to assess the apoptosis rate of chondrocytes, while immunofluorescence (IF) was utilized to evaluate the localization of CRLF1, cleaved-caspase3, MMP13, COL2A1, and ERK.</p></div><div><h3>Results</h3><p>The expression of CRLF1 was found to be significantly elevated in FJOA tissues compared to normal tissues. Through the use of loss-of-function assays, it was determined that CRLF1 not only enhanced the rate of apoptosis in chondrocytes, but also facilitated the degradation of the extracellular matrix in vitro. Furthermore, CRLF1 was found to activate the ERK1/2 pathways. The pro-arthritic effects elicited by CRLF1 were mitigated by treatment with the MEK inhibitor U0126 in chondrocytes.</p></div><div><h3>Conclusion</h3><p>These results suggest that CRLF1 enhances chondrocytes apoptosis and extracellular matrix degration in FJOA and thus may therefore be a potential therapeutic target for FJOA.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112543"},"PeriodicalIF":3.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S053155652400189X/pdfft?md5=1586af3634a732d2d338e865124ffcc2&pid=1-s2.0-S053155652400189X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pegylated chitosan nanoparticles of fluoxetine enhance cognitive performance and hippocampal brain derived neurotrophic factor levels in a rat model of local demyelination","authors":"Masoomeh Dadkhah ,&nbsp;Salva Afshari ,&nbsp;Tara Samizadegan ,&nbsp;Leila Rezaie Shirmard ,&nbsp;Sajjad Barin","doi":"10.1016/j.exger.2024.112533","DOIUrl":"10.1016/j.exger.2024.112533","url":null,"abstract":"<div><p>Cognitive impairment is a common feature in neurodegenerative diseases such as multiple sclerosis (MS). This study aims to explore the potential of enhancing the beneficial effects of fluoxetine (FLX), a neuroprotective agent known for its ability to increase neural plasticity by utilizing nanoparticles. The study specifically focuses on the synthesis and evaluation of PEGylated chitosan nanoparticles of FLX and its effect on demyelination and the subsequent cognitive impairment (CI) in the hippocampus of rats induced by local injection of lysophosphatidylcholine (LPC). Chitosan/polyethylene glycol nanoparticles were synthesized, and their properties were analyzed. Demyelination was induced in rats via hippocampal injections of lysolecithin. Behavioral assessments included open field maze, elevated plus maze, and novel object recognition memory (NORM) tests. Hippocampal levels of insulin-like growth factor (IGF-1) and brain-derived neurotrophic factor (BDNF) were measured using enzyme-linked immunoassay (ELISA). The extent of remyelination was quantified using Luxol fast blue staining. Nanoparticle size measured 240.2 nm with 53 % encapsulation efficacy. Drug release exhibited a slow pattern, with 76 % released within 4 h. Nanoparticle-treated rats displayed reduced anxiety-like behavior, improved memory, increased BDNF levels, and a reduced extent of demyelination, with no change in IGF- levels. In addition, FLX -loaded chitosan nanoparticles had better effect on cognitive improvement, BDNF levels in the hippocampus that FLX. Altering pharmacokinetics and possibly pharmacodynamics. These findings highlight the potential of innovative drug delivery systems, encouraging further research in this direction.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112533"},"PeriodicalIF":3.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S053155652400175X/pdfft?md5=e9b0ad87a793f405b1d3df5bdc5e37e5&pid=1-s2.0-S053155652400175X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between high-mobility group box-l and cognitive impairments induced by myocardial ischemia-reperfusion in elderly rats","authors":"Wenqu Yang,&nbsp;Jing Yu,&nbsp;Hui Wang,&nbsp;Jiandong He,&nbsp;Ruomeng Pei","doi":"10.1016/j.exger.2024.112540","DOIUrl":"10.1016/j.exger.2024.112540","url":null,"abstract":"<div><h3>Background</h3><p>Myocardial ischemia-reperfusion (MI/R) can lead to structural and functional abnormalities in the hippocampal neurons of the brain. High-mobility group box-l (HMGB1) is implicated in the activation of immune cells and the stimulation of inflammatory responses. However, the specific role of HMGB1 in cognitive impairment induced by MI/R in elderly rats has yet to be elucidated.</p></div><div><h3>Methods</h3><p>Elderly rats underwent surgical procedures to induce MI/R. To evaluate the learning and memory abilities of these rats, a water maze test and a new-object recognition test were administered. Nissl staining was utilised to examine hippocampal neuron damage. Enzyme-linked immunosorbent assay, western blotting, and real-time quantitative polymerase chain reaction (RT-qPCR) analyses were conducted to measure the expression levels of HMGB1, inflammatory cytokines, and molecular pathways.</p></div><div><h3>Results</h3><p>The study found that MI/R induced cognitive impairment in elderly rats. There was an observed increase in serum HMGB1 levels, along with elevated concentrations of pro-inflammatory cytokines in the plasma and hippocampus, accompanied by a decrease in anti-inflammatory cytokines. Moreover, substantial damage was evident in the hippocampal neurons of rats exposed to MI/R. In the brains of these rats, there was an increased expression of HMGB1, the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), phosphorylated p65, interleukin-1β (IL-1β), IL-6, IL-23, tumour necrosis factor-α (TNF-α), caspase-3, and Bax. In contrast, the expression of B-cell lymphoma 2 was decreased. The RT-qPCR analyses indicated elevated levels of HMGB1, RAGE, TLR4, IL-1β, IL-6, IL-23, TNF-α, caspase-3, and Bax mRNA.</p></div><div><h3>Conclusion</h3><p>The increased concentration of serum and hippocampal inflammatory factors in the brains of elderly rats subjected to MI/R suggests that cognitive impairment may be induced through the activation of the HMGB1/TLR4/NF-κB signalling pathway.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112540"},"PeriodicalIF":3.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001827/pdfft?md5=424806c78dce251e2456e3648326d0db&pid=1-s2.0-S0531556524001827-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of potential drug targets for amyotrophic lateral sclerosis by Mendelian randomization analysis based on brain and plasma proteomics","authors":"Ni Yang ,&nbsp;Liangyuan Shi ,&nbsp;Pengfei Xu ,&nbsp;Fang Ren ,&nbsp;Chunlin Li ,&nbsp;Xianghua Qi","doi":"10.1016/j.exger.2024.112538","DOIUrl":"10.1016/j.exger.2024.112538","url":null,"abstract":"<div><p>Amyotrophic lateral sclerosis as a fatal neurodegenerative disease currently lacks effective therapeutic agents. Thus, finding new therapeutic targets to drive disease treatment is necessary. In this study, we utilized brain and plasma proteins as genetic instruments obtained from genome-wide association studies to conduct a Mendelian randomization analysis to identify potential drug targets for amyotrophic lateral sclerosis. Additionally, we validated our results externally using other datasets. We also used Bayesian co-localization analysis and phenotype scanning. Furthermore, we constructed a protein-protein interaction network to elucidate potential correlations between the identified proteins and existing targets. Mendelian randomization analysis indicated that elevated levels of ANO5 (OR = 1.30; 95 % CI, 1.14–1.49; <em>P</em> = 1.52E-04), SCFD1 (OR = 3.82; 95 % CI, 2.39–6.10; <em>P</em> = 2.19E-08), and SIGLEC9 (OR = 1.05; 95% CI, 1.03–1.07; <em>P</em> = 4.71E-05) are associated with an increased risk of amyotrophic lateral sclerosis, with external validation supporting these findings. Co-localization analysis confirmed that ANO5, SCFD1, and SIGLEC9 (coloc.abf-PPH4 = 0.848, 0.984, and 0.945, respectively) shared the same variant with amyotrophic lateral sclerosis, further substantiating potential role of these proteins as a therapeutic target. There are interactive relationships between the potential proteins and existing targets of amyotrophic lateral sclerosis. Our findings suggested that elevated levels of ANO5, SCFD1, and SIGLEC9 are connected with an increased risk of amyotrophic lateral sclerosis and might be promising therapeutic targets. However, further exploration is necessary to fully understand the underlying mechanisms involved.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112538"},"PeriodicalIF":3.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001803/pdfft?md5=f5bcace43924b6f716667825bc30064e&pid=1-s2.0-S0531556524001803-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration","authors":"Farhad Sanaeifar ,&nbsp;Sina Pourranjbar ,&nbsp;Mohammad Pourranjbar ,&nbsp;Sana Ramezani ,&nbsp;Samira Rostami Mehr ,&nbsp;Al-Hassan Soliman Wadan ,&nbsp;Farnaz Khazeifard","doi":"10.1016/j.exger.2024.112539","DOIUrl":"10.1016/j.exger.2024.112539","url":null,"abstract":"<div><p>Neurodegenerative diseases (NDDs) are a class of neurological disorders marked by the progressive loss of neurons that afflict millions of people worldwide. These illnesses affect brain connection, impairing memory, cognition, behavior, sensory perception, and motor function. Alzheimer's, Parkinson's, and Huntington's diseases are examples of common NDDs, which frequently include the buildup of misfolded proteins. Cognitive-behavioral impairments are early markers of neurodevelopmental disorders, emphasizing the importance of early detection and intervention. Neurotrophins such as brain-derived neurotrophic factor (BDNF) are critical for neuron survival and synaptic plasticity, which is required for learning and memory. NDDs have been associated with decreased BDNF levels. Physical exercise, a non-pharmacological intervention, benefits brain health by increasing BDNF levels, lowering cognitive deficits, and slowing brain degradation. Exercise advantages include increased well-being, reduced depression, improved cognitive skills, and neuroprotection by lowering amyloid accumulation, oxidative stress, and neuroinflammation. This study examines the effects of physical exercise on cognitive-behavioral deficits and BDNF levels in the limbic system impacted by neurodegeneration. The findings highlight the necessity of including exercise into NDD treatment to improve brain structure, function, and total BDNF levels. As research advances, exercise is becoming increasingly acknowledged as an important technique for treating cognitive decline and neurodegenerative disorders.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112539"},"PeriodicalIF":3.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001815/pdfft?md5=4ec83cb25a79e8666eb1fe6a0dd2a0b1&pid=1-s2.0-S0531556524001815-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients","authors":"Estelle Tran Van Hoi ,&nbsp;Brent Appelman ,&nbsp;Simon Mooijaart ,&nbsp;Virgil A.S.H. Dalm ,&nbsp;Harmke A. Polinder Bos ,&nbsp;Diana van Heemst ,&nbsp;Bas F.M. van Raaij ,&nbsp;Raymond Noordam ,&nbsp;Anna Kuranova ,&nbsp;Jacobien J. Hoogerwerf ,&nbsp;Geeske Peeters ,&nbsp;Annemieke Smorenberg","doi":"10.1016/j.exger.2024.112534","DOIUrl":"10.1016/j.exger.2024.112534","url":null,"abstract":"<div><h3>Introduction</h3><p>During the COVID19 pandemic, older patients hospitalized for COVID-19 exhibited an increased mortality risk compared to younger patients. While ageing is associated with compromised immune responses and frailty, their contributions and interplay remain understudied. This study investigated the association between inflammatory markers and mortality and potential modification by frailty among older patients hospitalized for COVID-19.</p></div><div><h3>Methods</h3><p>Data were from three multicenter Dutch cohorts (COVID-OLD, CliniCo, Covid-Predict). Patients were 70 years or older, hospitalized for COVID-19and categorized into three frailty groups: fit (Clinical frailty score (CFS) 1–3), pre-frail (CFS 4–5), and frail (CFS 6–9). Immunological markers (lymphocyte count, neutrophil count, C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic inflammation index (SII)) were measured at baseline. Associations with in hospital mortality were examined using logistic regression.</p></div><div><h3>Results</h3><p>A total of 1697 patients were included from COVID-OLD, 656 from Covid-Predict, and 574 from CliniCo. The median age was 79, 77, and 78 years for each cohort. Hospital mortality rates were 33 %, 27 % and 39 % in the three cohorts, respectively. A lower CRP was associated with a higher frailty score in all three cohorts (all p &lt; 0.01). Lymphocyte count, neutrophil count, NLR, PLR, or SII, were similar across frailty groups. Higher CRP levels were associated with increased in-hospital mortality risk across all frailty groups, across all cohorts (OR (95 % CI), 2.88 (2.20–3.78), 3.15 (1.95–5.16), and 3.28 (1.87–5.92)), and frailty did not modify the association between inflammatory markers and in-hospital mortality (all p-interaction&gt;0.05).</p></div><div><h3>Conclusion</h3><p>While frailty is a significant factor in determining overall outcomes in older patients, our study suggests that the elevated risk of mortality in older patients with frailty compared to fit patients is likely not explained by difference in inflammatory responses.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112534"},"PeriodicalIF":3.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001761/pdfft?md5=d42e0c189d9227a0254629c232048fd3&pid=1-s2.0-S0531556524001761-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}