Experimental gerontology最新文献

{"title":"Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8+","authors":"Stefano Cacciatore ,&nbsp;Riccardo Calvani ,&nbsp;Jasmine Mancini ,&nbsp;Francesca Ciciarello ,&nbsp;Vincenzo Galluzzo ,&nbsp;Matteo Tosato ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi ,&nbsp;Lookup Study Group","doi":"10.1016/j.exger.2024.112666","DOIUrl":"10.1016/j.exger.2024.112666","url":null,"abstract":"<div><h3>Background</h3><div>Poor sleep quality may contribute to sarcopenia, but evidence remains sparse. This retrospective cross-sectional study investigated the association between subjective sleep quality and probable sarcopenia in a cohort of community-dwelling older adults enrolled in the Longevity Check-Up 8+ study.</div></div><div><h3>Methods</h3><div>Participants were asked about their sleep quality over the past month, with four possible options (“very good”, “quite good”, “quite bad”, very bad”). For the analysis, participants were grouped into good or bad sleep quality categories. Probable sarcopenia was operationalized according to handgrip strength values &lt; 27 kg for men and &lt; 16 kg for women. Logistic regression models were used to explore the relationship between sleep quality and probable sarcopenia.</div></div><div><h3>Results</h3><div>1971 participants were included in the analysis (mean age 73.4 ± 6.2 years, 50.0 % women). Bad sleep quality was reported by 28.3 % of participants and was more prevalent among women, physically inactive individuals, and those with dyslipidemia. Probable sarcopenia was more prevalent in participants with bad sleep quality (23.8 % vs. 18.7 %, <em>p</em> = 0.012). Logistic regression revealed that bad sleep quality was significantly associated with increased odds of probable sarcopenia in both unadjusted (odds ratio [OR] 1.36, 95 % confidence interval [CI] 1.07–1.72, <em>p</em> = 0.010) and fully adjusted models (OR 1.40, 95 % CI 1.08–1.81, <em>p</em> = 0.011).</div></div><div><h3>Conclusions</h3><div>Poor sleep quality is associated with increased likelihood of probable sarcopenia in older adults. This finding highlights the importance of addressing sleep quality in interventions aimed at preventing sarcopenia and promoting healthy aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112666"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study","authors":"Mingyi Yang ,&nbsp;Jiale Xie ,&nbsp;Yani Su ,&nbsp;Ke Xu ,&nbsp;Pengfei Wen ,&nbsp;Xianjie Wan ,&nbsp;Hui Yu ,&nbsp;Zhi Yang ,&nbsp;Lin Liu ,&nbsp;Peng Xu","doi":"10.1016/j.exger.2025.112682","DOIUrl":"10.1016/j.exger.2025.112682","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the genetic causality for the insomnia and common orthopedic diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), osteoporosis (OP), and gout (GT).</div></div><div><h3>Methods</h3><div>The genome-wide association study (GWAS) summary data on insomnia were obtained from a published study, while the GWAS summary data on RA, AS, OP, and GT were sourced from the FinnGen consortium. We utilized the TwoSampleMR package of the R software (version 4.1.2) to conduct a two-sample Mendelian randomization (MR) analysis. Our primary method of analysis was the random-effects inverse variance weighted (IVW) approach. Subsequently, we conducted a series of sensitivity analyses for the MR analysis.</div></div><div><h3>Results</h3><div>The MR analysis revealed a positive genetic causal relationship between insomnia and RA (<em>P</em> = 0.016, odds ratio [OR] 95 % confidence interval [CI] = 1.112 [1.020–1.212]). However, no significant genetic causal relationship was observed between insomnia and AS (<em>P</em> = 0.194, OR 95 % CI = 1.121 [0.944–1.331]), OP (<em>P</em> = 0.788, OR 95 % CI = 1.016 [0.904–1.142]), and GT (<em>P</em> = 0.757, OR 95 % CI = 1.018 [0.912–1.136]). The MR analysis did not exhibit heterogeneity, horizontal pleiotropy, outlier effects, or dependence on a single SNP, and demonstrated normal distribution, which guaranteed the robustness of the results.</div></div><div><h3>Conclusion</h3><div>The results of this study suggest that insomnia may be a significant risk factor for RA, and controlling insomnia may represent a promising strategy for preventing RA. While insomnia was not observed to be associated with AS, OP, and GT at the genetic level, other levels of association cannot be excluded.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112682"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of utility of wearable sensor technologies for older person frailty assessment","authors":"Chen Yixiao ,&nbsp;Shen Hui ,&nbsp;Song Quhong ,&nbsp;Zeng Xiaoxi ,&nbsp;Yue Jirong","doi":"10.1016/j.exger.2024.112668","DOIUrl":"10.1016/j.exger.2024.112668","url":null,"abstract":"<div><div>Frailty is one of the most concerning aspects of global population aging, and early identification is crucial to prevent or reverse its progression. Simple, universal, and efficient frailty assessment technologies are essential for the timely detection of frailty in older patients. Various multi-dimensional assessment instruments have been developed to quantify frailty phenotypes; we review the literature on wearable sensor technologies leveraged for older person frailty assessment. This review examines representative studies on older person frailty assessment published up to 2024, summarizing pertinent wearable sensor technologies utilized for frailty assessment. Our findings suggest that objective, simple, rapid, and affordable sensor-based frailty screening holds utility across diverse applications including diagnostic aid, prognostication, and endpoint ascertainment in research.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112668"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Vivifrail-B multicomponent exercise program based on society ecosystems theory on physical function in community-dwelling frail older adults: A randomized controlled trial","authors":"Yue Li ,&nbsp;Shasha Li ,&nbsp;Xu Weng ,&nbsp;Xinyu Yang ,&nbsp;Jianyi Bao ,&nbsp;Shufang Liao ,&nbsp;Yingxue Xi ,&nbsp;Xiaofang Song ,&nbsp;Guojing Guo","doi":"10.1016/j.exger.2024.112670","DOIUrl":"10.1016/j.exger.2024.112670","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to explore the short and long-term effects of the Vivifrail-B multicomponent exercise based on society ecosystems theory on physical function in community-dwelling frail older adults.</div></div><div><h3>Methods</h3><div>59 older adults were randomly assigned to the intervention (<em>n</em> = 30) and control (<em>n</em> = 29) groups. The exercise was performed thrice a week for 12 weeks, with one offline group training and two at home training. The Tilburg Frailty Indicator (TFI), the Short Physical Performance Battery (SPPB), Handgrip strength (HGS), the Physical Self-Maintenance Scale (PSMS), and the Instrumental Activities of Daily Living Scale (IADL) were assessed at baseline, 6 weeks, 12 weeks, 18 weeks, and 24 weeks. Exercise compliance assessments and satisfaction surveys were conducted at post intervention. Generalized estimating equations was used to compare outcome measures.</div></div><div><h3>Results</h3><div>At T1 (6-week), SPPB (<em>P</em> = 0.040) and PSMS (<em>P</em> = 0.042) of subjects in the intervention group were statistically different from the control group. At T2 (12-week), T3 (18-week) and T4 (24-week), all variables were significantly improved compared to the control group (all, <em>P</em> &lt; 0.05), except for IADL (P_T2 = 0.181, P_T3 = 0.192, P_T4 = 0.163). The short and long-term effects of the intervention were significant compared to the baseline level. However, the differences in Psychology (<em>P</em> = 0.699) and Society (<em>P</em> = 0.644) before and after the intervention were not significant.</div></div><div><h3>Conclusion</h3><div>Vivifrail-B multicomponent exercise based on society ecosystems theory improved physical function of community-dwelling frail older adults, and the older adults' exercise compliance and satisfaction were high.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112670"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials","authors":"Liang Ding ,&nbsp;Lijie Lou ,&nbsp;Mingyang Zhang ,&nbsp;Xing Zhang","doi":"10.1016/j.exger.2024.112652","DOIUrl":"10.1016/j.exger.2024.112652","url":null,"abstract":"<div><div>Aerobic and resistance exercises are widely recognized as essential for preserving and enhancing cognitive function. However, the effects of concurrent exercise on cognition in older adults remain unclear. This systematic review sought to evaluate the regular effects of concurrent aerobic and resistance training on global cognition in healthy older adults. A comprehensive search was conducted across PubMed, Web of Science, EMBASE, Google Scholar, Cochrane Library, and CNKI up to July 2024. Randomized controlled trials involving healthy older adults aged ≥65 years that assessed the cognitive effects of concurrent exercise were included. The methodological quality of the included studies was evaluated using the PEDro scale. Meta-analyses were performed using a random-effects model, and heterogeneity was quantified with the I² statistic. The initial search identified 13,533 records, ultimately including 12 studies in the meta-analysis, which involved 2557 participants. The meta-analysis revealed non-significant effects of concurrent exercise on global cognition (SMD = 0.12, 95 % CI: −0.08 to 0.33, <em>p</em> = 0.200). The subgroup analysis indicated that concurrent exercise cannot enhance global cognition compared to active controls (SMD = −0.03, 95 % CI: −0.23 to 0.18, <em>p</em> = 0.80), but it does show significant improvement compared to passive controls (SMD = 0.35, 95 % CI: 0.14 to 0.56, <em>p</em> &lt; 0.001). Moderate heterogeneity was observed (I² = 49.9 %), and sensitivity analyses confirmed the stability of the results. No significant publication bias was identified. While concurrent exercise was effective in improving global cognition in healthy older adults, the improvements were not superior to active control conditions. Future research should investigate optimal training combinations and sequences to maximize cognitive benefits.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112652"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of lower-limb isokinetic strength from functional fitness tests in older adults: A 550-participant cross-sectional study","authors":"Carlos Babiloni-López ,&nbsp;Pablo Jiménez-Martínez ,&nbsp;Carlos Alix-Fages ,&nbsp;Ángel Saez-Berlanga ,&nbsp;Álvaro Juesas ,&nbsp;Pedro Gargallo ,&nbsp;Javier Gene-Morales ,&nbsp;Juan C. Colado","doi":"10.1016/j.exger.2025.112683","DOIUrl":"10.1016/j.exger.2025.112683","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to explore the association and prediction of hip abduction-adduction and knee flexion-extension isokinetic absolute and relative strength and power at 60°/s and 180°/s from functional tests performance (i.e., Up-and-Go Test [seconds], 30-Second Chair Stand Test [repetitions and relative and allometric power], 30-Second Arm Curl Test [repetitions], and 6-Minute Walk Test [meters]) in older adults.</div></div><div><h3>Methods</h3><div>Five hundred and fifty participants (404 women; age: 69.12 ± 5.29 years) enrolled in this cross-sectional study. Participants attended the laboratory once. Isokinetic concentric-concentric strength was assessed before physical fitness tests. Agility and dynamic tests were completed before strength and aerobic resistance tests within the physical fitness tests.</div></div><div><h3>Results</h3><div>Significant trivial-to-moderate correlations (positive and negative) were found between all the tests and the isokinetic strength and power of the knee and the hip. The performance in the UGT and 6MWT showed the best direct correlations with isokinetic strength and power (|<em>r|</em> = 0.09–0.48), and the 30CS and 30 AC showed inconsistent positive and negative correlations (<em>r</em> = −0.46–0.44). Significant regression equations including the functional tests, age, and sex were found, with higher values for knee isokinetic strength and power (R² = 0.19–0.44) compared to hip (R² = 0.09–0.35) and no clear pattern regarding better or worse predictability at higher angular velocities.</div></div><div><h3>Conclusions</h3><div>Isokinetic knee and hip strength and power are associated with functional fitness in older adults. The functional fitness tests, along with age and sex are predictive variables of older adults' lower-limb isokinetic strength, although explaining at most 44 % of the variance.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112683"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice","authors":"Tianchan Peng ,&nbsp;Jian Xiang ,&nbsp;Yun Tian ,&nbsp;Xiaogen Tang ,&nbsp;Lina Wang ,&nbsp;Lijuan Gao ,&nbsp;Oscar Junhong Luo ,&nbsp;Li’an Huang ,&nbsp;Guobing Chen","doi":"10.1016/j.exger.2025.112686","DOIUrl":"10.1016/j.exger.2025.112686","url":null,"abstract":"<div><h3>Background</h3><div>Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking.</div></div><div><h3>Objective</h3><div>To investigate the geroprotective effects of <em>Lycium barbarum</em> glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model.</div></div><div><h3>Methods</h3><div>Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks to induce aging, while LbGp was orally administered (100 mg/kg/day) throughout the study. The geroprotective effects of LbGp were assessed by behavioral tests, cardiac echocardiography, pathohistological and transcriptomic analyses. Transmission electron microscopy was used to observe the ultrastructure of mitochondria. Mitochondrial stress assays and JC-1 fluorescent probe were conducted to evaluate mitochondrial function. Flow cytometer and western blot were performed to assess mitophagy flux.</div></div><div><h3>Results</h3><div>LbGp treatment improved the aging phenotypes of D-galactose-induced mice, with a pronounced enhancement in cardiac function compared to neurocognitive and skeletal muscle functions. Transcriptome analysis indicated that LbGp ameliorated energy metabolism in the heart. Mitochondrial assays revealed LbGp improved mitochondrial function and preserved structural integrity of the mitochondrial inner membrane. LbGp attenuated mitochondrial fission and restored impaired PINK1/Parkin-mediated mitophagy pathway caused by D-galactose in cardiomyocytes.</div></div><div><h3>Conclusion</h3><div>LbGp can ameliorate aging phenotypes and enhance cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice. These findings underscore its potential as a therapeutic agent for aging and aging-related cardiovascular diseases.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112686"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes","authors":"Kun Zhang ,&nbsp;Bo Hou ,&nbsp;Tao Yan ,&nbsp;Ruru Qiao ,&nbsp;Peng Qu ,&nbsp;Xinbo Xu ,&nbsp;Hanbing Zhang","doi":"10.1016/j.exger.2025.112676","DOIUrl":"10.1016/j.exger.2025.112676","url":null,"abstract":"<div><h3>Background</h3><div>Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets. Therefore, we performed a systematic genome-wide MR of drug-eligible individuals to explore potential therapeutic targets for ARHL.</div></div><div><h3>Methods</h3><div>We obtained data on the expression quantitative trait locis (eQTLs) of druggable genes, which were then subjected to two-sample MR analyses and co-localisation analyses with data from the ARHL genome-wide association study to identify genes highly associated with ARHL. Additionally, we conducted phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking to help develop more effective and targeted therapeutic treatments.</div></div><div><h3>Results</h3><div>Overall, the MR analysis of eQTL data showed that 14 drug targets were significantly associated with ARHL. GO analysis of 14 potential targets revealed their primary involvement in biological processes such as the endoplasmic reticulum unfolded protein response, ER-nucleus signaling pathway, and fibroblast apoptotic process. Additionally, important cellular components include the Bcl-2 family of proteins and the endoplasmic reticulum lumen. After filtering using methods such as phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking, six potentially druggable genes (BAK1, AMFR, LAMP3, STK17B, ACP5, and CD9) and six drugs (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, and naftidrofuryl) that may affect ARHL outcomes were finally identified.</div></div><div><h3>Conclusions</h3><div>Our findings identified 14 potential drug targets for ARHL. These findings offer promising leads for more effective treatments for ARHL and help determine the priority of drug development, potentially reducing costs.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112676"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis","authors":"Yijian Deng ,&nbsp;Liying Zeng ,&nbsp;Yigui Lai ,&nbsp;Shuai Ji ,&nbsp;Baizhao Peng ,&nbsp;Hanqi Lu ,&nbsp;Ming Wang ,&nbsp;Hiu Yee Kwan ,&nbsp;Qi Wang ,&nbsp;Xiaoshan Zhao","doi":"10.1016/j.exger.2025.112677","DOIUrl":"10.1016/j.exger.2025.112677","url":null,"abstract":"<div><h3>Background</h3><div>Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. Previous studies have underscored the association between BCAAs and CVD, but the causal link between BCAAs and ED remains uncertain.</div></div><div><h3>Methods</h3><div>The bidirectional Mendelian randomization (MR) study used the genetic data from genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with total BCAAs, leucine, isoleucine, and valine. The genetic data for ED were acquired from the FinnGen study (<em>n</em> = 95,178). The primary method used to assess causal associations was the inverse variance-weighted (IVW) method, supplemented by MR-Egger, weighted median, and simple median analyses. Cochrane's Q test was utilized to evaluate heterogeneity within the results, while the MR-Egger intercept test was utilized to evaluate the Level pleiotropy. A sensitivity analysis was performed employing leave-one-out analysis.</div></div><div><h3>Results</h3><div>The MR analysis results indicate a positive correlation between levels of total BCAA (OR = 1.984, 95 % CI = 1.018–3.868, <em>P</em> = 0.044), leucine (OR = 2.277, 95 % CI = 1.121–4.626, <em>P</em> = 0.023), isoleucine (OR = 2.584, 95 % CI = 1.167–5.722, <em>P</em> = 0.019), valine (OR = 1.894, 95 % CI = 1.119–3.206, <em>P</em> = 0.017), and the risk of ED. Sensitivity tests confirmed the accuracy and robustness of the study findings. Moreover, the reverse MR analysis found no association between ED and the BCAAs.</div></div><div><h3>Conclusion</h3><div>The results of this analysis indicate a positive association between the circulating BCAA concentrations and the risk of ED, but their underlying mechanisms require further investigation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112677"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study","authors":"Jeong Min Yang ,&nbsp;Jieun Hwang","doi":"10.1016/j.exger.2025.112681","DOIUrl":"10.1016/j.exger.2025.112681","url":null,"abstract":"<div><h3>Purpose</h3><div>Recently, the World Health Organization has emphasized the importance of a healthy lifestyle in reducing severe illnesses and premature mortality. To evaluate this, the Healthy Lifestyle Score (HLS), which focuses on health protecting behaviors (e.g., smoking, alcohol consumption, physical activity, body mass index), is widely used. However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. Accordingly, this study aims to track HLS trajectories (HLST) and examine their association with mortality among middle-aged and older Koreans.</div></div><div><h3>Methods</h3><div>After excluding missing values, data from 6249 participants were analyzed using the group-based trajectory model (GBTM) to classify HLST, based on the first to fourth waves of the Korean Longitudinal Study of Aging (KLoSA). The chi-square test and Cox proportional hazards model were employed to examine the association between HLST and all-cause mortality over a 10-year follow-up period (December 31, 2012, to December 31, 2022; 3650 days).</div></div><div><h3>Results</h3><div>Three HLST groups were identified in the GBTM analysis. These were the Poor HLST (17.8 %), Average HLST (42.9 %), and Good HLST (39.4 %) groups. Compared to the good HLST, the poor HLST had higher mortality at 1 year (hazard ratio [HR]: 1.98, p: 0.029), 3 years (HR: 1.78, p: 0.001), 5 years (HR: 1.52, p: 0.002), 7 years (HR: 1.39, p: 0.002), and 10 years (HR: 1.40, p: 0.000). Furthermore, stratified analysis by sex, age, marital status and residential region showed that male, ≥65 years, single and urban area groups had a strong association between HLST and all-cause mortality.</div></div><div><h3>Conclusion</h3><div>The findings of this study underscore the necessity of policies and institutional measures grounded in community networks to mitigate the risk of all-cause mortality among vulnerable groups with persistently poor HLST.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"200 ","pages":"Article 112681"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}