Experimental gerontology最新文献

{"title":"Establishment of a dexamethasone-induced zebrafish skeletal muscle atrophy model and exploration of its mechanisms","authors":"Chen-Chen Sun ,&nbsp;Ye-Jun Li ,&nbsp;Dan-Ting Zhu ,&nbsp;Zhang-Lin Chen ,&nbsp;Jiang-Ling Xiao ,&nbsp;Xiang-Tao Chen ,&nbsp;Lan Zheng ,&nbsp;Xi-Yang Peng ,&nbsp;Chang-Fa Tang","doi":"10.1016/j.exger.2024.112615","DOIUrl":"10.1016/j.exger.2024.112615","url":null,"abstract":"<div><h3>Background</h3><div>Skeletal muscle atrophy is one of the main side effects of high-dose or continuous use of glucocorticoids (such as dexamethasone). However, there are limited studies on dexamethasone-induced skeletal muscle atrophy in zebrafish and even fewer explorations of the underlying molecular mechanisms. This study aimed to construct a model of dexamethasone-induced skeletal muscle atrophy in zebrafish and to investigate the molecular mechanisms.</div></div><div><h3>Methods</h3><div>Zebrafish soaked in 0.01 % dexamethasone solution for 10 days. Loli Track (Denmark) and Loligo Swimming Respirometer were used to observe the effect of dexamethasone on swimming ability. The effects of dexamethasone on zebrafish skeletal muscle were observed by Transmission electron microscopy, H&amp;E, and wheat germ agglutinin techniques. Enriched genes and signaling pathways were analyzed using Transcriptome sequencing. Further, the levels of mitochondrial and endoplasmic reticulum-related proteins were examined to investigate possible mechanisms.</div></div><div><h3>Results</h3><div>0.01 % dexamethasone reduced zebrafish skeletal muscle mass (<em>p</em> &lt; 0.05), myofibre size and cross-sectional area (<em>p</em> &lt; 0.001), and increased protein degradation (ubiquitination and autophagy) (p &lt; 0.05). In addition, 0.01 % dexamethasone reduced the swimming ability of zebrafish, as evidenced by the reluctance to move, fewer movement trajectories, decreased total distance traveled (<em>p</em> &lt; 0.001), average velocity of movement (<em>p</em> &lt; 0.001), oxygen consumption (p &lt; 0.001), critical swimming speed (<em>p</em> &lt; 0.01) and increased exhaustive swimming time (p &lt; 0.001). Further, 0.01 % dexamethasone-induced mitochondrial dysfunction (decreased mitochondrial biogenesis, disturbs kinetic homeostasis, increased autophagy) and endoplasmic reticulum stress.</div></div><div><h3>Conclusions</h3><div>0.01 % dexamethasone induces skeletal muscle atrophy and impairs the swimming ability of zebrafish through mitochondrial dysfunction and endoplasmic reticulum stress.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112615"},"PeriodicalIF":3.9,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations – A narrative review","authors":"Kai Huang ,&nbsp;Haili Cai","doi":"10.1016/j.exger.2024.112614","DOIUrl":"10.1016/j.exger.2024.112614","url":null,"abstract":"<div><div>This comprehensive review examines the relationship between osteoarthritis (OA) and osteoporosis (OP), two common disorders in the elderly. OA involves joint cartilage degeneration and pain, while OP leads to fractures due to reduced bone mass. Despite different pathologies, both conditions share risk factors such as age and genetics. Studies reveal mixed results: some show higher bone mineral density (BMD) in OA patients, suggesting an inverse relationship, while others find no significant link. Proposed mechanisms include mechanical loading, bone remodeling, and inflammation. Clinical strategies focus on maintaining bone health in OA and monitoring joint health in OP, with treatments like bisphosphonates and exercise. Understanding these interactions is crucial for developing integrated treatments to improve patient outcomes and quality of life. Further research is needed to clarify these complex mechanisms.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112614"},"PeriodicalIF":3.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults: A cross-sectional study from UK Biobank","authors":"Abdulrahman T. Alsowail ,&nbsp;Marion T. Guerrero Wyss ,&nbsp;Frederick K. Ho ,&nbsp;Carlos Celis-Morales ,&nbsp;Stuart R. Gray","doi":"10.1016/j.exger.2024.112612","DOIUrl":"10.1016/j.exger.2024.112612","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.</div></div><div><h3>Research methods &amp; procedures</h3><div>A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women). The primary outcomes were grip strength index and muscle mass index, the predictor variable was n-3 fatty acid intake and the covariates were age, ethnicity, Townsend deprivation index, physical activity, multimorbidity count, total energy intake, body fat percentage and the month of assessment. Multivariable linear regression analyses were performed across 5 models. Model 1 was unadjusted; model 2 adjusted for age, ethnicity, deprivation index and month of assessment; model 3 adjusted as in model 2 plus total energy intake; model 4 as in model 2 plus multimorbidity count; and model 5 as in model 4 plus body fat percentage.</div></div><div><h3>Results</h3><div>In model 5, higher n-3 fatty acid intake was positively associated with the grip strength index in women. For each additional gram of n-3 fatty acid consumed per day, there was an increase of 0.03 kg/m² (95% CI: 0.00 to 0.06 kg/m²) in active women and 0.04 kg/m² (95% CI: 0.00 to 0.07 kg/m²) in inactive women. However, no significant associations were observed in men, whether active (<em>p</em> = 0.405) or inactive (<em>p</em> = 0.323). Additionally, no significant associations were found between n-3 fatty acid intake and muscle mass index in either active (<em>p</em> = 0.858) or inactive (<em>p</em> = 0.250) men, or in active (<em>p</em> = 0.909) or inactive (<em>p</em> = 0.187) women.</div></div><div><h3>Conclusion</h3><div>Although n-3 fatty acid intake was associated with grip strength index in older women, regardless of their activity status, the magnitude of this association was very small and unlikely to be clinically relevant. Additionally, n-3 fatty acid was not associated with muscle mass index.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112612"},"PeriodicalIF":3.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of multicomponent exercise on frailty status and physical function in frail older adults: A meta-analysis and systematic review","authors":"Xinyu Yang ,&nbsp;Shasha Li ,&nbsp;Lingfen Xu ,&nbsp;Haibing Liu ,&nbsp;Yue Li ,&nbsp;Xiaofang Song ,&nbsp;Jianyi Bao ,&nbsp;Shufang Liao ,&nbsp;Yingxue Xi ,&nbsp;Guojing Guo","doi":"10.1016/j.exger.2024.112604","DOIUrl":"10.1016/j.exger.2024.112604","url":null,"abstract":"<div><h3>Objectives</h3><div>The study aimed to carry out a systematic review and meta-analysis to explore the effects of multicomponent exercise on frailty status and physical function in frail older adults.</div></div><div><h3>Design</h3><div>A systematic review and meta-analysis.</div></div><div><h3>Setting and participants</h3><div>Older adults aged ≥60 years diagnosed with frailty using the Frailty Assessment Tool.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang were searched from inception to March 10, 2024. Two reviewers independently screened and selected the publications, extracted the data, and assessed risk of bias. This study included randomized controlled trials and quasi-experimental designs. Review Manager 5.4 was used for data analysis.</div></div><div><h3>Results</h3><div>Twenty-eight randomized controlled trials with 4857 older adults were included. Multicomponent exercise significantly improved frailty status (SMD = −1.40, 95 % CI:−2.05 to −0.75, P &lt; .05) and had a significant impact on physical function (muscle strength: SMD = 0.31, 95 % CI: 0.01–0.61, P &lt; .05; gait speed: SMD = 0.27, 95 % CI: 0.02–0.52, P &lt; .001; balance: SMD = 0.27, 95 % CI: 0.05–0.49, P = .02; Short Physical Performance Battery [SPPB]: SMD = 1.03, 95 % CI: 0.65–1.42, P &lt; .001; and Timed Up and Go [TUG]: SMD = −3.05, 95 % CI: −3.90 to −2.19, P &lt; .001). Subgroup analysis suggested that a 12-week duration is optimal for multicomponent exercise interventions, demonstrating significantly greater effectiveness in hospital compared with out-of-hospital.</div></div><div><h3>Conclusions</h3><div>Multicomponent exercise intervention can improve frailty status in older adults and promote enhancement of physical functional abilities (muscle strength, gait speed, balance, SPPB, and TUG). Therefore, a possible protective effect of multicomponent exercise in frailty older adults is suggested.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112604"},"PeriodicalIF":3.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent interplay of phosphate and inflammation on muscle strength irrespective of muscle mass in middle-aged and older adults","authors":"Chih-Ping Chung ,&nbsp;Bo-An Chen ,&nbsp;Wei-Ju Lee ,&nbsp;Chih-Kuang Liang ,&nbsp;Pei-Lin Lee ,&nbsp;Li-Ning Peng ,&nbsp;Liang-Kung Chen","doi":"10.1016/j.exger.2024.112613","DOIUrl":"10.1016/j.exger.2024.112613","url":null,"abstract":"<div><h3>Background</h3><div>Elevated circulatory phosphate levels are linked to age-related muscle dysfunction, yet the mechanisms remain unclear. This study investigated the hypothesis that inflammation plays a role in connecting elevated phosphate levels to muscular dysfunction in middle-aged and older individuals and explored potential sex-based differences in these associations.</div></div><div><h3>Methods</h3><div>The study, based on the I-Lan Longitudinal Aging Study Cohort, analyzed individuals' serum phosphate and hsCRP levels. Sex-specific analyses explored links between circulatory phosphate, inflammation, and muscle profiles (mass, handgrip strength, and walking speed). The study also examined potential mediation or synergistic effects of inflammation in the circulatory phosphate-muscle relationship.</div></div><div><h3>Results</h3><div>The study included 2006 participants (mean age: 65.5 ± 6.5 years; 49.8 % men). Women exhibited higher circulatory phosphate levels than men. Linear analyses revealed that higher phosphate levels were significantly associated with weaker handgrip strength but not with reduced muscle mass in both men and women. In women, circulatory phosphate was not associated with inflammation (hsCRP levels), while in men, higher phosphate levels were significantly associated with higher hsCRP levels. In men, a synergistic effect was observed, where the combination of high hsCRP and elevated phosphate levels had a more pronounced impact on reducing handgrip strength than either factor alone.</div></div><div><h3>Conclusions</h3><div>This study highlights a sex-specific association of inflammation in the mechanisms of hyperphosphatemia-related muscle weakness. The findings emphasize the importance of managing both hyperphosphatemia and chronic inflammation to mitigate their collective impact on muscle function, particularly in older men. Addressing these factors is crucial for promoting muscle health in later life.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112613"},"PeriodicalIF":3.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sarcopenic obesity and osteoarthritis: The potential mediating role of insulin resistance","authors":"Zijian Li ,&nbsp;Shishu Yin ,&nbsp;Gang Zhao,&nbsp;Xianglong Cao","doi":"10.1016/j.exger.2024.112611","DOIUrl":"10.1016/j.exger.2024.112611","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenic obesity (SO) and osteoarthritis (OA) are highly prevalent musculoskeletal conditions that significantly impair health-related quality of life.</div></div><div><h3>Aim</h3><div>This study investigated the association between SO and OA, and explored the potential mediating role of insulin resistance in this relationship. We utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis employs NHANES data collected from 1999 to 2018, including participants aged 18 years and older. SO was assessed using dual-energy X-ray absorptiometry (DXA) measurements. Insulin resistance was estimated using the triglyceride-glucose (TyG) index. OA status was based on self-reported physician diagnosis. Statistical analyses included weighted logistic regression, restricted cubic spline (RCS) interaction analysis, mediation analysis using structural equation modeling (SEM), and receiver operating characteristic (ROC) curve analysis. Subgroup analyses were conducted based on age, sex, and diabetes status.</div></div><div><h3>Results</h3><div>The sarcopenic obese group demonstrated the highest prevalence of OA (23.4 %), hypertension (47.8 %), and diabetes (12.0 %). Additionally, they exhibited elevated levels of triglycerides, cholesterol, glucose, blood urea nitrogen (BUN), creatinine, and uric acid. Logistic regression revealed significant positive associations between sarcopenic obesity, the TyG index, and OA risk. RCS analysis identified significant non-linear relationships and interactions of the TyG index with age, sex, and diabetes status on OA risk. Mediation analysis indicated that the TyG index mediated approximately 4.9 % of the effect of sarcopenic obesity on OA risk. ROC curve analysis demonstrated moderate diagnostic accuracy for the TyG index (AUC = 0.65), which improved when incorporated into the multivariate model (AUC = 0.78). Subgroup analyses confirmed significant associations between the TyG index and sarcopenic obesity with OA risk across different age, sex, and diabetes status categories.</div></div><div><h3>Conclusion</h3><div>Our findings suggest a significant correlation between insulin resistance, as measured by the TyG index, and elevated OA risk in individuals with sarcopenic obesity. Targeting insulin resistance through future research may be a promising avenue to lower OA risk in this population.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112611"},"PeriodicalIF":3.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exergaming interventions for older adults: The effect of game characteristics on gameplay","authors":"Helen Müller ,&nbsp;Nina Skjæret-Maroni ,&nbsp;Ellen Marie Bardal ,&nbsp;Beatrix Vereijken ,&nbsp;Jochen Baumeister","doi":"10.1016/j.exger.2024.112610","DOIUrl":"10.1016/j.exger.2024.112610","url":null,"abstract":"<div><h3>Purpose</h3><div>Exergames can be used to train physical and cognitive abilities and have been shown to be effective in reducing the risk of falls in older adults. However, there is limited evidence about how people play exergames and how gameplay is affected by game settings and, thus, the potential training effects. The aim of this study was to investigate the impact of repeated exergaming sessions over 4 weeks and two game settings (difficulty level and game speed) on gameplay (performance, physical activity and perceived exertion) in older adults over a four-week exergaming intervention.</div></div><div><h3>Methods</h3><div>28 independently living older adults (mean age 74.47 years; 14 females) played two different exergames (Puzzle and Fox) at two difficulty levels 3× per week for 4 weeks. Physical activity measures from an accelerometer at the lower back, performance as game scores from the exergaming system, and self-reported measures of physical and cognitive exertion were collected at sessions 1,2,3,6,9 and 12.</div></div><div><h3>Results</h3><div>For the Puzzle game, performance and physical activity increased significantly across the 12 training sessions. For the Fox game, an increased game speed was associated with increased performance, physical activity, and exertion across the exergaming sessions. Across all exergaming sessions, increasing difficulty by adding cognitive elements decreased the performance and amount of physical activity.</div></div><div><h3>Conclusion</h3><div>Game characteristics significantly influence how the exergames are played during a 4-week exergaming intervention. Hence, individual tailoring of the difficulty level and game speed is important. This study highlights the importance of understanding the interplay between game characteristics and gameplay during an exergaming intervention, thereby adding critical information for interpreting intervention effects – or the lack thereof.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112610"},"PeriodicalIF":3.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of moderate-intensity aquatic treadmill exercise on cognitive function and cerebral blood flow for healthy older adults","authors":"Billy, C.L. So ,&nbsp;Hiko, C.Y. Cheung ,&nbsp;Y.P. Zheng ,&nbsp;Manny, M.Y. Kwok ,&nbsp;Eugenie, Y.K. Man ,&nbsp;Fabiola, Tang Mok ,&nbsp;Gerald, C.N. Ng ,&nbsp;Nicco, N.L. Sze ,&nbsp;Stella, W.S. Tang ,&nbsp;Shamay, S.M. Ng","doi":"10.1016/j.exger.2024.112605","DOIUrl":"10.1016/j.exger.2024.112605","url":null,"abstract":"<div><div>To compare the effect of moderate-intensity aquatic treadmill exercise (ATM) on cerebral blood flow (CBF) and cognitive function in healthy older adults to that of moderate-intensity land-based treadmill exercise (LTM). This randomized controlled trial study was conducted between May 2023 and Oct 2023. Twenty-eight participants aged 60–80 were randomly assigned to either ATM group (N = 14) or LTM group (N = 14). Cognitive function and cerebral blood flow were assessed before and after the exercise. The outcome measures used in this study were the Digit Symbol Substitution Test (DSST) and the Digit Span Test (DST) to assess cognitive performance, and the mean middle cerebral artery blood velocity (MCAvmean) to evaluate CBF. A mixed effects model was used to analyze the within-group and between-group differences in cognitive function and CBF outcomes pre-to-post treadmill by SPSS. The DSST demonstrated a statistically significant improvement within both the ATM [β ± SE: −13.643 ± 2.407, 95 % CI: −18.749, −8.537] and LTM [β ± SE: −19.25 ± 3.66, 95 % CI: −26.424, −12.076] groups, indicating clinical significance in both groups. Both ATM and LTM groups exhibited post-exercise improvements within their respective groups for forward Digit Span Test (FDST) [ATM β ± SE: −0.143 ± 0.362, 95 % CI: −0.92, 0.634; LTM β ± SE: −0.286 ± 0.37, 95 % CI: −1.078, 0.506] and backward Digit Span Test (BDST) (ATM β ± SE: −1.741 ± 5.377, 95 % CI: −13.27, 9.792; LTM β ± SE: −6.729 ± 5.370, 95 % CI: −4.788, 18.24). In terms of MCAv_mean, there is a higher improvement of CBF in ATM group [β ± SE: −138.669 ± 67.9217, 95 % CI: −288.164, 10.826] than LTM group [β ± SE: −9.305 ± 70.076, 95 % CI: −153.617, 135.007]. Hence, a single bout of moderate-intensity ATM and LTM can enhance cognitive function and CBF in healthy older adults, suggesting their potential as preventive strategies against age-related declines.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112605"},"PeriodicalIF":3.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LRE-MMF: A novel multi-modal fusion algorithm for detecting neurodegeneration in Parkinson's disease among the geriatric population","authors":"Indranath Chatterjee ,&nbsp;Videsha Bansal","doi":"10.1016/j.exger.2024.112585","DOIUrl":"10.1016/j.exger.2024.112585","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a prevalent neurological disorder characterized by progressive dopaminergic neuron loss, leading to both motor and non-motor symptoms. Early and accurate diagnosis is challenging due to the subtle and variable nature of early symptoms. This study aims to address these diagnostic challenges by proposing a novel method, Localized Region Extraction and Multi-Modal Fusion (LRE-MMF), designed to enhance diagnostic accuracy through the integration of structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) data. The LRE-MMF method utilizes the complementary strengths of sMRI and rs-fMRI: sMRI provides detailed anatomical information, while rs-fMRI captures functional connectivity patterns. We applied this approach to a dataset consisting of 20 PD patients and 20 healthy controls (HC), all scanned with a 3 T MRI. The primary objective was to determine whether the integration of sMRI and rs-fMRI through the LRE-MMF method improves the classification accuracy between PD and HC subjects. LRE-MMF involves the division of imaging data into localized regions, followed by feature extraction and dimensionality reduction using Principal Component Analysis (PCA). The resulting features were fused and processed through a neural network to learn high-level representations. The model achieved an accuracy of 75 %, with a precision of 0.8125, recall of 0.65, and an AUC of 0.8875. The validation accuracy curves indicated good generalization, with significant brain regions identified, including the caudate, putamen, thalamus, supplementary motor area, and precuneus, as per the AAL atlas. These results demonstrate the potential of the LRE-MMF method for improving early diagnosis and understanding of PD by effectively utilizing both sMRI and rs-fMRI data. This approach could contribute to the development of more accurate diagnostic tools.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112585"},"PeriodicalIF":3.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake","authors":"Nur Zuliani Ramli ,&nbsp;Mohamad Fairuz Yahaya ,&nbsp;Nur Azlina Mohd Fahami ,&nbsp;Hamizah Shahirah Hamezah ,&nbsp;Zulzikry Hafiz Abu Bakar ,&nbsp;Aslina Pahrudin Arrozi ,&nbsp;Daijiro Yanagisawa ,&nbsp;Ikuo Tooyama ,&nbsp;Meharvan Singh ,&nbsp;Hanafi Ahmad Damanhuri","doi":"10.1016/j.exger.2024.112607","DOIUrl":"10.1016/j.exger.2024.112607","url":null,"abstract":"<div><div>The menopausal transition is a complex neuroendocrine aging process affecting brain structure and metabolic function. Such changes are consistent with neurological sequelae noted following the menopausal transition, including cognitive deficits. Although studies in rodent models of the menopause revealed changes in learning and memory, little is known about the structural and metabolic changes in the brain regions serving the cognitive function in these models. The administration 4-vinylcyclohexene diepoxide (VCD) in laboratory animals results in follicular depletion, and thus, is a powerful translational tool that models the human menopause. In the studies presented here, we evaluated behavior, brain structure, and metabolism in young female rats administered with either VCD or vehicle for 15 days across the early, mid, and post-follicular depletion states at 1-, 2-, and 3-months post-final injection, respectively. Additionally, we evaluated the serum hormonal profile and ovarian follicles based on the estrous cycle pattern. Positron emission tomography (PET) was utilized to determine regional brain glucose metabolism in the hippocampus, medial prefrontal cortex, and striatum. Subsequently, the rats were euthanized for ex-vivo magnetic resonance imaging (MRI) to assess regional brain volumes. VCD-induced rats at the post-follicular depleted time points had diminished spatial learning and memory as well as reduced hippocampal glucose uptake. Additionally, VCD-induced rats at post-follicular depletion time points had marked reductions in estradiol, progesterone, and anti-mullerian hormone with an increase in follicle-stimulating hormone. These rats also exhibited fewer ovarian follicles, indicating that substantial ovarian function loss during post-follicular time points impairs the female rats' spatial learning/memory abilities and triggers the metabolic changes in the hippocampus.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112607"},"PeriodicalIF":3.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}