Experimental gerontology最新文献

{"title":"Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort","authors":"Hao Sun ,&nbsp;Dong-Wan Chen ,&nbsp;Yuan-Ye Ma ,&nbsp;Bai Liu ,&nbsp;Jun Wang ,&nbsp;Yu-Jie Lai ,&nbsp;Gui-Hua Zeng ,&nbsp;Ying-Ying Shen ,&nbsp;Cheng-Rong Tan ,&nbsp;Xian-Le Bu ,&nbsp;Fan Zeng ,&nbsp;Yan-Jiang Wang","doi":"10.1016/j.exger.2025.112689","DOIUrl":"10.1016/j.exger.2025.112689","url":null,"abstract":"<div><h3>Background</h3><div>Platelet factor 4 (PF4), a chemotactic factor secreted from the α-granules of platelets, has recently been proved to mitigate neuroinflammation and improve aging-related cognition decline, which may be involved in Alzheimer's disease (AD).</div></div><div><h3>Objective</h3><div>This study aims to investigate the alterations of serum PF4 levels in AD, the correlation between serum PF4 and β-amyloid (Aβ) and tau levels in cerebrospinal fluid (CSF), and the potential diagnostic utility of PF4 in AD.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted involving 38 amyloid-positive AD patients and 50 cognitively normal controls. The levels of serum PF4 were detected using the Human CXCL4/PF4 enzyme-linked immunosorbent assay (ELISA) Kit. The levels of CSF Aβ42, Aβ40, p-tau181, and t-tau were measured on the fully-automated Lumipulse G1200 platform via commercially available kits.</div></div><div><h3>Results</h3><div>The levels of serum PF4 were significantly decreased in AD patients (5163.51 (3198.24–6301.15) vs. 5859.29 (4126.06–8006.70), Z = −2.30, <em>P</em> = 0.021). The negative correlation between AD diagnosis (β = −1972.292, <em>P</em> = 0.009) and PF4 levels retained after the adjustments of age, sex, <em>APOE</em> ε4 status, platelet count, platelet distribution width (PDW), and comorbidity of dyslipidemia in the multiple linear regression analysis. Further analysis showed that serum PF4 levels were positively correlated with CSF Aβ42 levels and Mini-Mental State Examination (MMSE) scores, and negatively correlated with CSF t-tau levels. Besides, the area under the curve (AUC) of serum PF4 for AD (AUC = 0.6437, <em>P</em> = 0.022) was comparable to that of CSF Aβ40 (AUC = 0.6400) yet lower than those of CSF Aβ42, ptau181, and t-tau. The AUC slightly increased when combining serum PF4 with other CSF AD biomarkers separately.</div></div><div><h3>Conclusions</h3><div>The serum levels of PF4 were decreased in AD patients and were significantly correlated with the cognitive function and CSF levels of Aβ42 and t-tau. PF4 may become a promising anti-aging and therapeutic target for AD, which is worthy of further study.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112689"},"PeriodicalIF":3.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and time-course changes in hemodynamic and physical performance parameters following single and multiple resistance training sets in cognitively impaired individuals: A randomized crossover study","authors":"Nuno Fonseca ,&nbsp;Dulce Esteves ,&nbsp;Diogo Luís Marques ,&nbsp;Luís Brandão Faíl ,&nbsp;Tiago Sousa ,&nbsp;Mafalda Pamplona Pinto ,&nbsp;Henrique Pereira Neiva ,&nbsp;Mikel Izquierdo ,&nbsp;Mário Cardoso Marques","doi":"10.1016/j.exger.2025.112688","DOIUrl":"10.1016/j.exger.2025.112688","url":null,"abstract":"<div><div>This study analyzed the acute and time-course changes following one resistance training (RT) set (1SET) and three sets (3SET) on hemodynamic and physical performance parameters in individuals with different cognitive impairment levels. Thirty-nine individuals (22 women and 17 men aged 80 ± 9 years) grouped by cognitive impairment (mild [MILD], moderate [MOD], and severe [SEV]) randomly performed two protocols, each separated by one week, of 1SET or 3SET of 10 repetitions. Before (PRE), immediately (POST), and 72 h after (POST72) protocols, the participants performed the following measurements: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), 1-kg medicine ball throw (MBT) distance, five-repetition sit-to-stand (STS) time, and handgrip strength (HGS). A three-way ANOVA with repeated measures revealed no significant differences between 1SET and 3SET on SBP, DBP, HR, STS, MBT, and HGS in any group at any time (all <em>p</em> ≥ 0.05). SEV increased SBP and HR from PRE to POST and decreased STS time after 3SET. From POST to POST72, all groups decreased SBP after both protocols, and SEV improved STS time after 3SET and HGS following both protocols. Furthermore, from PRE to POST72, MILD decreased SBP, while SEV improved HGS following 1SET and STS time following 3SET. These findings demonstrate that single and multiple sets cause acute hemodynamic changes, with a tendency to reduce SBP within 72 h. Additionally, individuals with worse cognitive function showed greater adaptive responses over time in physical performance, with 1SET improving HGS and 3SET enhancing STS performance.</div><div>Trial registration: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> ID: <span><span>NCT06185010</span><svg><path></path></svg></span></div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"201 ","pages":"Article 112688"},"PeriodicalIF":3.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China","authors":"Decheng Li ,&nbsp;Yunhe Wang ,&nbsp;Shuai Guo ,&nbsp;Ziyang Ren ,&nbsp;Binbin Su ,&nbsp;Lichuan Zhang ,&nbsp;Zuliyaer Talifu ,&nbsp;Xiaoying Zheng","doi":"10.1016/j.exger.2024.112656","DOIUrl":"10.1016/j.exger.2024.112656","url":null,"abstract":"<div><h3>Background</h3><div>Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.</div></div><div><h3>Methods</h3><div>We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS). IC was evaluated across cognitive, locomotion, psychological, sensory, and vitality domains. Asymmetry and weakness were measured using the maximum value of HGS. Logistic regression models were employed to examine the association of the individual and combined groupings of HGS asymmetry and weakness with IC impairment (a total score ≥ 2 across five domains). The potential non-linear relationship was explored using a restricted cubic spline (RCS) model.</div></div><div><h3>Results</h3><div>Of the 4798 participants included (median age 66.0 years, IQR 63.0–71.0 years; 56.9 % male), 35.2 % had IC impairment. HGS asymmetry (<em>OR</em> = 1.26, 95 % <em>CI</em>: 1.11–1.43) and weakness (<em>OR</em> = 2.09, 95 % <em>CI</em>: 1.78–2.45) were both independent risk factors for IC impairment. Notably, participants experiencing both HGS asymmetry and weakness were at even higher risk of IC impairment (<em>OR</em> = 2.47, 95 % <em>CI</em>: 1.99–3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between HGS status and impairments in specific IC domains, particularly in locomotion. In contrast to other domains, it was the Weakness only group, rather than the Both group, that had the highest risk of vitality impairment. There was a U-shaped relationship between HGS asymmetry and IC impairment.</div></div><div><h3>Conclusions</h3><div>HGS asymmetry and weakness were associated with an increased risk of composite and individual domain IC impairment. Assessing and maintaining HGS symmetry and strength may have implications for the early identification of individuals at risk for IC impairment and the prevention of related adverse health outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112656"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive analysis of sarcopenia markers in young adults with down syndrome","authors":"Brett S. Nickerson ,&nbsp;Michael R. Esco ,&nbsp;George Schaefer ,&nbsp;Elroy J. Aguiar ,&nbsp;Stefan A. Czerwinski","doi":"10.1016/j.exger.2024.112655","DOIUrl":"10.1016/j.exger.2024.112655","url":null,"abstract":"<div><h3>Background</h3><div>Most body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.</div></div><div><h3>Objective</h3><div>This brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.</div></div><div><h3>Methods</h3><div>Fourteen young adults (age = 26 ± 9 yrs.) with DS (males: <em>n</em> = 6; females: <em>n</em> = 8) had appendicular skeletal muscle mass (ASM) measured with bioimpedance analysis and handgrip strength (HGS) measured with a hand dynamometer (dominant hand). Sarcopenia was computed using the European Working Group on Sarcopenia in Older People revised definition (EWGSOP2).</div></div><div><h3>Results</h3><div>The BMI for the entire group was 24.41 ± 4.01 kg/m², ranging from 16.21 to 31.31 kg/m², with one participant classified as obese. ASM ranged from 11.33 to 24.41 kg (17.49 ± 4.71 kg), and 64 % of participants fell below the EWGSOP2 criteria for muscle mass. HGS ranged from 8 to 31 kg (20 ± 7 kg), and 57 % of participants fell below the EWGSOP2 criteria for muscular strength. Lastly, 5 of 14 participants (approximately 36 %) had sarcopenia according to the EWGSOP2 definition.</div></div><div><h3>Conclusion</h3><div>An alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112655"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor","authors":"Xin Xu ,&nbsp;Hui Yu ,&nbsp;Mingyi Yang ,&nbsp;Jiale Xie ,&nbsp;Ke Xu ,&nbsp;Erliang Li ,&nbsp;Xianjie Wan ,&nbsp;Jiachen Wang ,&nbsp;Guoqiang Wang ,&nbsp;Ying Pan ,&nbsp;Peng Xu ,&nbsp;Junfei Guo","doi":"10.1016/j.exger.2024.112657","DOIUrl":"10.1016/j.exger.2024.112657","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) and obstructive sleep apnea (OSA) are prevalent chronic conditions with emerging evidence suggesting a potential link. However, the causality of this association remains unclear, possibly influenced by confounders like high body mass index (BMI). This study aimed to explore causal relationships between OA and OSA using Mendelian randomization (MR).</div></div><div><h3>Methods</h3><div>MR analysis was performed to assess causality between OA and OSA. Inverse variance weighting (IVW) was the primary MR method, complemented by sensitivity analyses, including MR steiger, MR-Egger, MR-PRESSO, weighted median, heterogeneity tests, and leave-one-out approaches to evaluate pleiotropy and confirm the robustness of the causal estimates. To exclude confounding effects of BMI, we also used a multivariate MR (MVMR).</div></div><div><h3>Results</h3><div>After adjusting for BMI through MVMR, no significant causal relationship was identified between genetically predicted OSA and OA phenotypes, including knee (KOA) and hip osteoarthritis (HOA), suggesting that obesity largely drives the observed relationship between these conditions. Similarly, MR steiger doesn't support a causal effect from OA on OSA. Sensitivity analyses confirmed the robustness of these results, with no significant evidence of horizontal pleiotropy or heterogeneity affecting outcomes. The findings indicate that BMI acts as a critical confounder in the relationship between OSA and OA, rather than OSA directly contributing to OA development.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that there is no significant causal relationship between genetically predicted OSA and OA after adjusting for BMI. These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. Future research should aim to validate these findings in diverse populations and explore other metabolic pathways that may contribute to these complex associations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112657"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing fracture risk indication: The impact of bone load index and muscle fat infiltration on vertebral compression fracture","authors":"Xiao-Yue Jiang ,&nbsp;Zhi-Yang Tang ,&nbsp;Bo-Wen Liu ,&nbsp;Si-Yuan Lu ,&nbsp;Dong-Gang Pan ,&nbsp;Hui Jiang ,&nbsp;Xiu-Hong Shan","doi":"10.1016/j.exger.2024.112654","DOIUrl":"10.1016/j.exger.2024.112654","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to identify risk factors for vertebral compression fracture and enhance the ability to indicate fracture risk.</div></div><div><h3>Methods</h3><div>A retrospective collection of clinical and imaging data was conducted for patients with vertebral compression fractures and control subjects who underwent quantitative computed tomography scans. Stepwise logistic regression analysis was employed to identify variables associated with fractures, constructing both unadjusted model and adjusted model.</div></div><div><h3>Results</h3><div>Compared with the non-fracture group, the fracture group showed significant differences in weight, body mass index (BMI), bone mineral density (BMD), vertebral cross-sectional area, paraspinal muscle area and right psoas major muscle fat area (all <em>P</em> &lt; 0.05). Adjusted characteristics analyzed by stepwise logistic regression indicated that bone load index (BLI) (OR = 3.19, <em>P</em> = 0.041), paraspinal muscle fat infiltration (PMFI) (OR = 2.27, <em>P</em> = 0.039), and right psoas major muscle fat infiltration (RPMFI) (OR = 1.08, <em>P</em> = 0.005) were independent risk factors for vertebral fractures. Interaction analysis revealed a positive interaction between BLI and PMFI (OR = 1.95, <em>P</em> = 0.008) as well as RPMFI (OR = 1.53, <em>P</em> = 0.045). Compared with the unadjusted model, the diagnostic performance of the adjusted model was significantly improved (training set IDI: 19.5 %, validation set IDI: 18.4 %, <em>P</em> &lt; 0.001). Correlation analysis demonstrated significant associations between BMD (<em>r</em> = −0.353, <em>P</em> = 0.002), BLI (<em>r</em> = 0.631, <em>P</em> &lt; 0.001), PMFI (<em>r</em> = 0.412, P &lt; 0.001), RPMFI (<em>r</em> = 0.513, P &lt; 0.001), and the degree of vertebral compression.</div></div><div><h3>Conclusion</h3><div>Under conditions of bone maladaptive loading and muscle degeneration, vertebral bodies may become more susceptible to external forces, increasing the risk of vertebral compression fracture.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112654"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma volume variations in response to high intensity interval training in obese women: The influential role of menopausal status and age","authors":"Georges Jabbour ,&nbsp;Maha Sellami ,&nbsp;Horia-Daniel Iancu","doi":"10.1016/j.exger.2024.112664","DOIUrl":"10.1016/j.exger.2024.112664","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the effects of high-intensity interval training (HIIT) on plasma volume (PV) variations in obese women, with a focus on understanding how menopausal status and age influence these changes.</div></div><div><h3>Methods</h3><div>We enrolled fifty-nine obese women (perimenopausal and postmenopausal), aged approximately 56.6 years in a six-week HIIT program. Measurements of fitness, health, and PV were taken before and after the intervention. PV was assessed at two points during each session: at post-warm-up (PV1), and immediately post-training (PV2). These measurements were derived using hematocrit (Ht) and hemoglobin (Hb) values.</div></div><div><h3>Results</h3><div>The intervention led to notable reductions in anthropometric measures and blood pressure (<em>P</em> &lt; 0.01). For all women pre- and post-HIIT comparisons revealed significant differences in the extent of PV reduction at all two points (P &lt; 0.01). Multiple linear regression analysis revealed that age was a significant contributor to the decreases in plasma volume (PV) observed both after warm-up and following the supramaximal cycling test - SCT (<em>r</em> = 0.44 and <em>r</em> = 0.57). On the other hand, menopause status was an independent predictor for PV decreases after warm-up (<em>r</em> = 0.33) as well after SCT (<em>r</em> = 0.38). Following HIIT, only menopause status accounted for 19 % of the variation in PV decreases after warm-up and 21 % of the variation in PV decreases after SCT.</div></div><div><h3>Conclusions</h3><div>The findings suggest that HIIT is effective in enhancing plasma volume among obese menopausal women, attenuating the age-related decline in PV.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112664"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index and its associations with cardiovascular diseases and cancer: Evidence form NHANES 2017–2018 and Mendelian randomization analysis","authors":"Xuehua Wang ,&nbsp;Qian Xu ,&nbsp;Wenhu Liu,&nbsp;Jingjie Xiong,&nbsp;Han Li,&nbsp;Ni Xiong,&nbsp;Yan Wang,&nbsp;Zhaohui Wang","doi":"10.1016/j.exger.2024.112665","DOIUrl":"10.1016/j.exger.2024.112665","url":null,"abstract":"<div><h3>Objective</h3><div>Cardiovascular diseases (CVDs) and cancer are significant global causes of mortality. However, the link between diets that promote inflammation and various subtypes of CVDs and cancers remains unclear.</div></div><div><h3>Methods</h3><div>Utilizing the dataset from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) data release cycle, our study encompassed 3538 adult participants within the age range of 20 to 80 years. The dietary questionnaire information was utilized to calculate dietary inflammatory index (DII) scores. Logistic regression analysis was employed to validate the association between the DII and CVDs, as well as overall cancer and special type cancer. Mediation analysis was conducted to evaluate the relationship between DII and the aforementioned diseases, with hemoglobin serving as the potential mediator. Mendelian randomization (MR) analysis externally validated hemoglobin's causal link to these diseases.</div></div><div><h3>Results</h3><div>Patients with the highest quartile levels of DII scores demonstrated an elevated prevalence of congestive heart failure (CHF), stroke, overall cancer and some specific types of cancers. The logistic regression analysis revealed a correlation between DII and CHF (OR = 1.197, <em>p</em> = 0.002), stroke (OR = 1.205, <em>p</em> &lt; 0.001), as well as breast cancer (OR = 1.306, <em>p</em> = 0.004). The pro-inflammatory diet also resulted in lower hemoglobin levels (p &lt; 0.001). Mediation analyses found a role for hemoglobin in the relationship of DII and CVDs.</div></div><div><h3>Conclusions</h3><div>Both CVDs and cancer risk were positively correlated with the DII in our study. Hemoglobin emerged as a potential mediator in the intricate relationship between DII and CHF, as well as stroke.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112665"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receiving financial support and its association with late-age depression: The mediating role of social engagement","authors":"Keying Song ,&nbsp;Zijian Zhao ,&nbsp;Amiya Saha ,&nbsp;Jhumki Kundu","doi":"10.1016/j.exger.2024.112647","DOIUrl":"10.1016/j.exger.2024.112647","url":null,"abstract":"<div><h3>Objectives</h3><div>Researchers have long been concerned with the association between family financial support and depression in older adults. However, it remains unclear whether social engagement influences the relationship between depression and financial support in later life. Therefore, this study aims to examine the relationship between receiving financial support from family and others and depression among Indian older adults and to also explore the mediating effect of social engagement on this relationship.</div></div><div><h3>Subjects and methods</h3><div>Data from the Longitudinal Aging Study in India Wave 1 (2017–2018) was used for the empirical analysis. A total sample of 30,210 older adults aged 60 years and above were selected for the study. The study employs bivariate and binary logistic regression analysis. Further Karlson–Holm–Breen method was adopted for mediation analysis.</div></div><div><h3>Results</h3><div>The adjusted prevalence of depression among older adults who did not receive financial support from family or others was nearly 33.8 % (men: 29.8 %, women: 37.4 %), compared to 29.9 % for those who received support (men: 27.6 %, women: 32 %). Older adults who received financial support had 21 % lower odds of depression (AoR: 0.79; 95 % CI: 0.73, 0.84) than those who did not. Additionally, the association between depression and receiving financial support was mediated by social engagement (17.3 %) with the mediating effect being higher among older women (29.3 %) than older men (13.5 %).</div></div><div><h3>Conclusion</h3><div>The study advances that although financial support plays a significant role in reducing depressive symptoms in older adults, social engagement also serves as an important mediator in this relationship. Enhancing opportunities for social engagement may amplify the protective effects of financial support, offering a more comprehensive approach to addressing mental health challenges among aging populations in India.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112647"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice","authors":"Nida Rasheed ,&nbsp;Hafiza Khushbakht Hussain ,&nbsp;Zohabia Rehman ,&nbsp;Azka Sabir ,&nbsp;Waseem Ashraf ,&nbsp;Tanveer Ahmad ,&nbsp;Faleh Alqahtani ,&nbsp;Imran Imran","doi":"10.1016/j.exger.2024.112659","DOIUrl":"10.1016/j.exger.2024.112659","url":null,"abstract":"<div><div>Aluminum chloride (AlCl₃), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays a pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes and efficacy of CoQ10 and curcumin low dose (100 mg/kg each) combination in 18-months old geriatric male Balb/c mice subjected to AlCl₃-prompted memory derangements (200 mg/kg in water bottles) for 28 days. The neuroprotective properties driven by antioxidant mechanisms were assessed via observing cellular pathology in key-memory related brain regions including the cornuammonis (CA3 and DG) and cortex 2/3 layer. Our outcomes revealed that AlCl₃ exposure significantly reduced spatial learning and memory. In contrast, CoQ10 and curcumin combinatorial regime markedly mitigated cognitive deficits Vs. individual high-dose in AlCl₃-treated animals as demonstrated by their improved performance in neurobehavioral tests such as the Y-maze, novel object recognition, passive avoidance and Morris-water maze test. Additionally, CoQ10 and curcumin co-administration restored redox balance by significantly reducing the levels of oxidative stressor (MDA) and increasing the anti-oxidant capacity (SOD,GPx). AchE is an enzyme involved in acetylcholine breakdown which negatively impacts acetylcholine levels and memory function. AlCl₃ exposure elevated AchE levels in mice brains vs. treatment. This neurochemical alteration was notably reversed in the dual-treatment group. Furthermore, CoQ10 and curcumin ameliorated AlCl₃-induced neurotoxicity by preserving neuronal cytoarchitecture in both cortical and hippocampal regions. In conclusion, CoQ10 and curcumin combination might attenuate memory loss induced by AlCl₃-intoxication via restoring aberrant AchE activity, enhanced anti-oxidant defenses and salvaging the deleterious neuronal damage.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112659"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}