Experimental gerontology最新文献

{"title":"Shadow puppetry therapy enhances dementia-related cognitive function and interpersonal relationship","authors":"Shu-Yuan Chao ,&nbsp;Hsiao-Mei Chen ,&nbsp;Bei-Yi Su","doi":"10.1016/j.exger.2024.112667","DOIUrl":"10.1016/j.exger.2024.112667","url":null,"abstract":"<div><h3>Background</h3><div>With the growing demand for dementia care, non-pharmacological interventions, such as creative arts therapies, have been proven effective in stabilizing cognitive function. Shadow Puppetry Therapy (SPT), which integrates visual, auditory, and kinesthetic elements, offers a promising care option for individuals with dementia.</div></div><div><h3>Objective</h3><div>This study evaluated the effectiveness of SPT on cognitive function, self-esteem, and interpersonal relationships among older adults with mild dementia.</div></div><div><h3>Methods</h3><div>We adopted a quasi-experimental design and recruited 33 older adults with mild dementia from two dementia care centers. Older adults with mild dementia were randomly assigned to an experimental group (<em>n</em> = 15) and a control group (<em>n</em> = 18). The experimental group participated in a 16-week SPT program, and the control group engaged in regular activities, such as physical exercises, painting, cooking, music, and handicraft projects. Assessments included the short portable mental status questionnaire (SPMSQ), the Rosenberg self-esteem scale (RSES), and the interpersonal relationship scale, with evaluations conducted before and after the intervention.</div></div><div><h3>Results</h3><div>The intervention significantly improved cognitive function, self-esteem, and interpersonal relationships in the experimental group. SPMSQ scores decreased, indicating enhanced cognitive function (<em>p</em> = .001), while self-esteem and interpersonal relationship scores showed significant improvements (<em>p</em> = .001). No significant changes were observed in the control group.</div></div><div><h3>Conclusion</h3><div>SPT is an effective non-pharmacological intervention for enhancing cognitive function, self-esteem, and interpersonal relationships in older adults with mild dementia. The findings support the integration of creative arts therapies into dementia care.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112667"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for the special issue on “microbiomes in extremes of aging”","authors":"Hariom Yadav ,&nbsp;Varsha D. Badal ,&nbsp;Michal M. Masternak ,&nbsp;Christiaan Leeuwenburgh","doi":"10.1016/j.exger.2024.112663","DOIUrl":"10.1016/j.exger.2024.112663","url":null,"abstract":"<div><div>This special issue of the <em>Journal of Experimental Gerontology</em> explores the dynamic interplay between microbiomes and aging-related conditions. The four selected studies highlight the role of microbiota in Alzheimer's disease, cancer immunotherapy, myocardial infarction and tryptophan metabolism, providing insights into how microbiomes influence health and disease in aging. These studies underscore the potential for microbiome-targeted interventions to mitigate aging-related disorders and improve the quality of life for older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112663"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure","authors":"Kengo Yoshida ,&nbsp;Zhenqiu Liu ,&nbsp;Yoshiko Kubo ,&nbsp;Masahiko Miura ,&nbsp;Mika Yamaoka ,&nbsp;Hiroko Nagamura ,&nbsp;Munechika Misumi ,&nbsp;Yoichiro Kusunoki","doi":"10.1016/j.exger.2024.112646","DOIUrl":"10.1016/j.exger.2024.112646","url":null,"abstract":"<div><div>The T cell aging process can be modified by genotoxic factors, including ionizing radiation, and metabolic controls, such as caloric restriction; the former accelerates and the latter retards the process. However, the mechanisms by which these systemic factors interact to cause T cell aging remain unclear. This study investigated the naïve T-cell pool, thymic cellularity, and transcriptome in mice irradiated with 3.8 Gy at 5 weeks of age and treated 13 months later with 30 mM spermidine (SPD), a metabolism regulator. The number of conventional naïve CD4 and CD8 T cells in the peripheral blood decreased 14 months after irradiation whereas the number of virtual memory naïve T cells, which increased with age, further increased by irradiation. However, these radiation-related changes were not significant in similarly irradiated mice that were subsequently treated with SPD. The numbers of total, double-positive, and single-positive thymocytes were decreased by irradiation, whereas none were decreased in the irradiated mice treated with SPD. RNA sequencing of thymus cells revealed 803 upregulated genes in irradiated mice compared with those in non-irradiated control mice, with these genes enriched in leukocyte activation and inflammatory cytokine production. However, only 22 genes were upregulated in irradiated and SPD-treated mice, suggesting a reversal of many radiation-induced gene expression changes. These findings suggest that SPD may alleviate radiation-induced acceleration of T-cell aging, particularly by mitigating reduced thymopoiesis and inflammation. Further research is warranted to explore the rejuvenating potential of SPD and its mechanisms of action in accelerated T-cell aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112646"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly","authors":"Mahdie Dehnavi ,&nbsp;Najmeh Valizadeh zare ,&nbsp;Seyd Reza Mazlom ,&nbsp;Samira Mohajer ,&nbsp;Tahereh Sadeghi ,&nbsp;Mohammad Namazinia ,&nbsp;Danial Baghie","doi":"10.1016/j.exger.2024.112661","DOIUrl":"10.1016/j.exger.2024.112661","url":null,"abstract":"<div><h3>Background</h3><div>The increasing elderly population is a complex and globally significant phenomenon impacting various sectors of society, including healthcare. By 2050, it is projected that one-fourth of Iran's population will be elderly. Falls are a major concern among the elderly, leading to physical and psychological injuries and imposing significant financial burdens on healthcare and social systems. Given the widespread acceptance of smartphones and mobile health applications, however limited research has been conducted on the effectiveness of mobile applications in training caregivers for home safety and accident prevention in elderly populations.</div></div><div><h3>Methods</h3><div>This randomized clinical trial was conducted in 2022 in Mashhad, Iran. The sample consisted of 66 elderly caregivers, randomly assigned to intervention and control groups. Data collection tools included a demographic information questionnaire and the Home Safety Self-Assessment Tool (HSSAT). The intervention group used a home safety educational application, while the control group received educational brochures. Data were analyzed using SPSS software and appropriate statistical tests.</div></div><div><h3>Results</h3><div>Sixty-two elderly caregivers participated in the study, with a mean age of 72 ± 37.7 years. The chi-square test showed no significant difference in gender distribution between the intervention and control groups (<em>p</em> = 0.060). The majority of participants in both groups had a high school education. Before the training, there was no significant difference in the mean accident risk management scores between the two groups (<em>p</em> = 0.713). Repeated measures ANOVA revealed a significant time effect (F(1, 60) = 408, <em>p</em> &lt; 0.001, Partial η² = 0.872) and a significant group effect (F(1, 60) = 5, <em>p</em> = 0.025, Partial η² = 0.081). Additionally, the interaction between time and group was significant (F(1, 60) = 6, <em>p</em> = 0.015, Partial η² = 0.095), indicating a greater improvement in accident risk management scores in the intervention group compared to the control group.</div></div><div><h3>Conclusions</h3><div>The use of home safety educational applications can effectively reduce the risk of accidents and improve preventive measures management among the elderly. These modern educational tools can alleviate the burden on healthcare systems and save costs associated with in-person training. Future research should continue exploring innovative educational methods to enhance the safety and well-being of the elderly population.</div></div><div><h3>Trial registration</h3><div>This study was registered in the Iranian Registry of Clinical Trials (no. IRCT20210610051532N1) on 07/09/2021.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"199 ","pages":"Article 112661"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower extremity muscle hypertrophy in response to resistance training in older adults: Systematic review, meta-analysis, and meta-regression of randomized controlled trials","authors":"Davi Alves de Santana ,&nbsp;Pedro Godoi Scolfaro ,&nbsp;Emanuele Marzetti ,&nbsp;Cláudia Regina Cavaglieri","doi":"10.1016/j.exger.2024.112639","DOIUrl":"10.1016/j.exger.2024.112639","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the effects of resistance training (RT) on knee extensor muscle hypertrophy in adults 65 years and older.</div></div><div><h3>Methods</h3><div>A systematic search was carried out in PubMed, Embase, and Scopus to review randomized controlled trials that assessed the effects of supervised RT on 1) muscle size, 2) fiber area, and 3) leg lean mass (LLM). Random-effects meta-analyses of standardized mean difference (SMD) and raw mean difference (RMD) for LLM were calculated. We performed a meta-regression to examine the interference of age, training volume, and duration on the results related to hypertrophy at muscle and fiber levels.</div></div><div><h3>Results</h3><div>Thirty-two studies were included in the review, and 28 were meta-analyzed. The meta-analysis found a significant effect of RT on muscle size (SMD = 0.34; 95 % CI: 0.16–0.52; <em>p</em> &lt; 0.001) and fiber area (SMD = 0.54; 95 % CI: 0.24–0.84; <em>p</em> &lt; 0.001), but not on LLM (RMD = 0.22; 95 % CI: −0.22-0.66 <em>p</em> = 0.321<em>). A</em> subanalysis of studies that assessed quadriceps femoris size (excluding isolated quadriceps femoris muscles from the analysis) also revealed a significant effect of RT (95 % CI: 0.20–0.69; <em>p</em> <em>&lt;</em> <em>0.001)</em>. Regression analysis indicated a significant influence of intervention duration on type II fiber area (<em>p</em> <em>=</em> <em>0.034),</em> while no significant influence was detected for weekly sets or age for any outcome measure.</div></div><div><h3>Conclusions</h3><div>RT promotes muscle hypertrophy in older adults at both whole-muscle and fiber levels, with training duration potentially influencing the response. Measures of leg lean mass may not capture RT-induced adaptation.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112639"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of precision health management combined with dual-energy bone densitometer treatment on bone biomarkers in senile osteoporosis patients","authors":"Zhixing Du ,&nbsp;Xiaojing Yan ,&nbsp;Yongjian Liu,&nbsp;Yongbin Pei,&nbsp;Jin Zhou,&nbsp;Lei Zhang,&nbsp;Dandan Han,&nbsp;Litao Chen","doi":"10.1016/j.exger.2024.112642","DOIUrl":"10.1016/j.exger.2024.112642","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the effects of precision health management combined with dual-energy X-ray absorptiometry (DXA) therapy on bone biomarkers in elderly osteoporotic patients.</div></div><div><h3>Methods</h3><div>236 elderly patients diagnosed with osteoporosis between May 2020 and November 2021 were enrolled from our hospital. Patients were randomly allocated to either the observation group (<em>n</em> = 118), receiving precision health management alongside DXA therapy, or the control group (<em>n</em> = 118), receiving standard treatment. Clinical data were compared between the two groups. Protein levels of bone formation markers (BSAP, OC) and bone resorption markers (CTX, DPD, TRAP) were analyzed using Western blotting. Bone mineral density (BMD) was measured using DXA at baseline, 12 months, and 24 months. Pain levels were assessed using the Visual Analog Scale (VAS) at the same intervals. Osteoporosis knowledge and self-management confidence were evaluated using respective scales before and after intervention.</div></div><div><h3>Results</h3><div>Baseline characteristics did not significantly differ between groups (<em>P</em> &gt; 0.05). The observation group exhibited decreased BSAP and increased OC and OC protein expressions compared to the control group (<em>P</em> &lt; 0.05). CTX, DPD, and TRAP protein levels were significantly lower in the observation group (<em>P</em> &lt; 0.05). Prior to the intervention, there were no significant variations observed in BMD, as well as VAS, knowledge, and self-efficacy scores between the two groups (<em>P</em> &gt; 0.05). However, over the course of 12 and 24 months, the observation group exhibited significant increases in BMD (<em>P</em> &lt; 0.05). VAS scores were notably lower in the observation group during both follow-up assessments (<em>P</em> &lt; 0.05). Furthermore, knowledge scores were higher in the observation group at 12 and 24 months (<em>P</em> &lt; 0.05), while self-efficacy scores showed significant improvement in the observation group at both follow-up intervals (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Precision health management combined with DXA therapy positively impacts elderly osteoporotic patients by enhancing bone biomarkers, promoting bone growth, and preventing bone loss. This approach leads to increased BMD, reduced fracture risk, improved pain management, and enhanced knowledge and self-management abilities related to osteoporosis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112642"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate effects of structured and natural deep breathing on heart rate variability and blood pressure in community-dwelling older adults","authors":"Ting-Ting Yeh ,&nbsp;Yi-Chieh Ho","doi":"10.1016/j.exger.2024.112644","DOIUrl":"10.1016/j.exger.2024.112644","url":null,"abstract":"<div><h3>Background</h3><div>This study investigated the immediate effects of structured deep breathing (SDB) and natural deep breathing (NDB) on heart rate variability (HRV) and blood pressure (BP) in community-dwelling older adults.</div></div><div><h3>Methods</h3><div>Twenty-six participants were randomly assigned to SDB (<em>n</em> = 14) or NDB (<em>n</em> = 12) groups. HRV parameters (time domain: standard deviation of normal-to-normal intervals [SDNN], root mean square of successive differences [RMSSD]; frequency domain: low frequency [LF], high frequency [HF], LF/HF ratio, total power [TP], normalized low frequency [LFnu], normalized high frequency [HFnu]) and BP were assessed during spontaneous breathing, DB, and post DB.</div></div><div><h3>Results</h3><div>Both groups showed significant increases during DB in SDNN (<em>p</em> &lt; 0.001), RMSSD (<em>p</em> = 0.021), LF power (<em>p</em> &lt; 0.001), LFnu (p &lt; 0.001), TP (<em>p</em> &lt; 0.001), and LF/HF ratio (p &lt; 0.001). HFnu decreased significantly during DB (p &lt; 0.001) with no group differences. HF power showed no significant effect in group and time. BP remained stable throughout the protocol, with no significant changes in either systolic or diastolic BP across time points or between groups.</div></div><div><h3>Conclusions</h3><div>This first direct comparison of structured versus natural DB in healthy older adults demonstrates that both approaches effectively enhance parasympathetic activity. These findings support DB as a cost-effective, accessible intervention for promoting autonomic balance in healthy aging, without requiring specialized equipment or instruction.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112644"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake” [Exp. Gerontol. 197 (2024) 112607]","authors":"Nur Zuliani Ramli ,&nbsp;Mohamad Fairuz Yahaya ,&nbsp;Nur Azlina Mohd Fahami ,&nbsp;Hamizah Shahirah Hamezah ,&nbsp;Zulzikry Hafiz Abu Bakar ,&nbsp;Aslina Pahrudin Arrozi ,&nbsp;Daijiro Yanagisawa ,&nbsp;Ikuo Tooyama ,&nbsp;Meharvan Singh ,&nbsp;Hanafi Ahmad Damanhuri","doi":"10.1016/j.exger.2024.112627","DOIUrl":"10.1016/j.exger.2024.112627","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112627"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in mortality risk and U-shaped relationship with klotho levels: A long-term cohort study","authors":"Junwen Wang ,&nbsp;Lin Bai ,&nbsp;Yuyang Ye,&nbsp;Xuefeng Chen,&nbsp;Xinru Hu,&nbsp;Yong Peng","doi":"10.1016/j.exger.2024.112643","DOIUrl":"10.1016/j.exger.2024.112643","url":null,"abstract":"<div><h3>Backgrounds</h3><div>It remains unclear whether there are sex differences in the correlation between klotho and mortality risk. The purpose of our study is to investigate the relationship between klotho levels and all-cause mortality, specifically examining potential sex disparities.</div></div><div><h3>Methods</h3><div>The study utilized data from the National Health and Nutrition Examination Survey. The study employed the Cox proportional hazards model and Kaplan-Meier survival curves to conduct multivariate analyses investigating the associations between klotho and mortality. The impact of klotho level on mortality was assessed by a restricted cubic spline curve.</div></div><div><h3>Results</h3><div>Our study included 13,748 participants. The hazard ratios (HR) for all-cause mortality were found to be higher in males compared to females. The risk of all-cause mortality decreased until the klotho level reached 959 pg/mL in all-cause mortality, then increased thereafter in females (<em>P</em> value for nonlinearity = 0.01, P overall = 0.02); no curved relationship was observed in males.</div></div><div><h3>Conclusion</h3><div>Klotho levels and mortality follow a U-shaped curve, with sex differences in the relationship. Males with higher klotho levels have a higher risk of all-cause death than females.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112643"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific poor physical performance in Korean community-dwelling older adults","authors":"Kai Wang ,&nbsp;Suyeon Kim ,&nbsp;Taehyun Song ,&nbsp;Seongryu Bae ,&nbsp;Hyuntae Park ,&nbsp;S. Jun Son","doi":"10.1016/j.exger.2024.112636","DOIUrl":"10.1016/j.exger.2024.112636","url":null,"abstract":"<div><h3>Background</h3><div>Poor physical performance appears to be different across age and sex. The aim of this study was to examine changes in physical performance across age groups by sex.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted with 292 community-dwelling older adults (144 males, 148 females; age: 74.7 ± 5.2 years, body mass index: 23.8 ± 2.7 kg/m²). Physical performance tests included (i) strength (handgrip, knee extension, ankle dorsiflexion, ankle plantarflexion, and toe grip), (ii) functional mobility (5 sit-to-stand, 4-m gait speed, and 4-m fast gait speed), and (iii) postural control (timed single-leg stance). Physical performance was compared across four different age groups by sex using ANOVA tests, T-score, and linear regression analysis. All statistical analysis was set at 0.05.</div></div><div><h3>Results</h3><div>ANOVA showed a significant age effect (<em>p</em> &lt; 0.05) on physical performance measures with only exception for ankle muscle strength. T-score and linear regression analyses revealed sex-specific trends. In males, postural control showed the most significant poor performance, followed by strength. In females, the most notable poor performance was also observed in postural control, followed by functional mobility.</div></div><div><h3>Conclusions</h3><div>Most main outcome measures in physical performance worsened over time across age groups while poor performance pattern was different between older males (strength) and females (functional mobility). We highlighted the importance of assessing strength, functional mobility, and postural control in older adults. Based on observed poor performance patterns across age groups by sex, sex-specific interventions should be implemented.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112636"},"PeriodicalIF":3.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}