Experimental gerontology最新文献

{"title":"A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions","authors":"Ismail A. Ibrahim ,&nbsp;Ahmed Hosney Nada ,&nbsp;Nada Khalid Asar ,&nbsp;Rand Ibrahim ,&nbsp;Rawan Ahmed Farouk ,&nbsp;Almonzer Al-Qiami ,&nbsp;Sarah A. Nada ,&nbsp;Parisa Alizadeh Oghyanous ,&nbsp;Seyed Ali Noorbakhsh","doi":"10.1016/j.exger.2024.112551","DOIUrl":"10.1016/j.exger.2024.112551","url":null,"abstract":"<div><p>Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"196 ","pages":"Article 112551"},"PeriodicalIF":3.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001979/pdfft?md5=85c12d056d091c77a0db43abc6d37ed1&pid=1-s2.0-S0531556524001979-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease","authors":"Yanghong Zou ,&nbsp;Tao Huang ,&nbsp;Ailan Pang ,&nbsp;Houjun Zhou ,&nbsp;Xin Geng","doi":"10.1016/j.exger.2024.112558","DOIUrl":"10.1016/j.exger.2024.112558","url":null,"abstract":"<div><h3>Background</h3><p>Parkinson's disease (PD) is a common central neurodegenerative disease in middle-aged and elderly people. The progressive degeneration and death of dopaminergic neurons leads to insufficient dopamine (DA) neurotransmitters. Acupuncture and moxibustion can alleviate the aging of neurons. Therefore, studying the neuroprotective effects of electroacupuncture (EA) in PD mice is particularly important.</p></div><div><h3>Methods</h3><p>Intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg) was used to establish a PD mouse model, and lipopolysaccharide (LPS) was used to induce microglia polarization. Western blotting, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), Nissl staining and immunohistochemistry were used to detect neuronal apoptosis and injury, α-syn expression and microglial accumulation in PD mice. In addition, the levels of inflammatory factors were determined using enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to detect the Ca²⁺ content. The fluorescein isothiocyanate (FITC) labeling method was used to assess glucose uptake. A reagent kit was used to detect glucose and lactate levels.</p></div><div><h3>Results</h3><p>MPTP induced the selective loss of DA neurons in the SN of mice, altered Ca²⁺ homeostasis, and induced an inflammatory response. In addition, maintaining Ca²⁺ homeostasis depends on the activity of transient receptor potential channel 1 (TRPC1). EA therapy promotes TRPC1 expression, which has a negative regulatory effect on sodium–glucose cotransporter 1 (SGLT1). Under the action of EA, TRPC1 protein expression increased, Ca²⁺ concentrations increased, and the effect of SGLT1 was inhibited, thereby facilitating glucose metabolism, blocking the activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway, restraining M1 polarization of microglia, and alleviating the PD process.</p></div><div><h3>Conclusion</h3><p>EA promotes TRPC1/Ca²⁺ pathway activation, inhibits SGLT1-mediated regulation of glucose metabolism and PI3K/AKT pathway activation, inhibits microglial M1 polarization, and alleviates PD.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"196 ","pages":"Article 112558"},"PeriodicalIF":3.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002043/pdfft?md5=09ec3aec4214aa48f61a985bee54c284&pid=1-s2.0-S0531556524002043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity & sedentary time on frailty in adults with chronic kidney disease: Cross-sectional NHANES study","authors":"Guixing Zeng ,&nbsp;Yujie Lin ,&nbsp;Peirui Xie ,&nbsp;Jiarong Lin ,&nbsp;Yaxing He ,&nbsp;Junping Wei","doi":"10.1016/j.exger.2024.112557","DOIUrl":"10.1016/j.exger.2024.112557","url":null,"abstract":"<div><h3>Objective</h3><p>A considerable percentage of individuals with chronic kidney disease (CKD) are reported to be frail. Lower physical activity and higher sedentary time are most consistently associated with frailty among the potentially alterable risk factors. Although the single effect of physical activity or sedentary time on suppressing frailty have been widely studied, whether physical activity can mitigate or counteract the detrimental consequences of higher sedentary time on frailty among CKD population has never been explored. This study aims to explore whether and to what extent the correlation between sedentary time and frailty was diminished by physical activity among CKD population.</p></div><div><h3>Study design and setting</h3><p>Data were acquired from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018 cycles. Frailty index was assessed using 49-item deficit model. Physical activity and sedentary time were measured using the Global Activity Questionnaire. Weighted binary logistic regression models, restricted cubic spline models and sensitivity analyses were performed to investigate the aforementioned relationship.</p></div><div><h3>Results</h3><p>The final sample included 2551 adults aged ≥20 years with CKD, which is represented a weighted number of 4.98 million noninstitutionalized US population. In the fully adjusted model, the group with low physical activity was 1.56 (95 % CI:1.19, 2.03) times more likely to develop frailty than the group with high physical activity and each unit of increase of sedentary time was associated with an 41 % increased risk of frailty (OR = 1.41, 95 % CI = 1.04–1.89). Our findings also indicated that engaging in 1240–6200 MET-min/week of high physical activity was associated with a decreased risk of frailty related to moderate-to-high sedentary time among CKD population (OR = 0.69, 95 % CI = 0.49–0.99, <em>P</em> = 0.044). In subgroup analyses, high physical activity was associated with a 0.43-fold (95%CI: 0.24, 0.77) decreased risk of moderate-to-high sedentary time associated with frailty in female groups and a significant modification effect of gender was uncovered (P_interaction = 0.024).</p></div><div><h3>Conclusion</h3><p>High physical activity was associated with a decreased risk of frailty related to moderate-to-high sedentary time in adults with CKD, especially in females subgroups.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112557"},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002031/pdfft?md5=ea9b25e3f01beb4095cd22b0aa8c9034&pid=1-s2.0-S0531556524002031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal postcentral gyrus voxel-mirrored homotopic connectivity as a biomarker of mild cognitive impairment: A resting-state fMRI and support vector machine analysis","authors":"Ziruo Li ,&nbsp;Chunyan Huang ,&nbsp;Xingfu Zhao ,&nbsp;Yujun Gao ,&nbsp;Shenglan Tian","doi":"10.1016/j.exger.2024.112547","DOIUrl":"10.1016/j.exger.2024.112547","url":null,"abstract":"<div><h3>Background</h3><p>While patients affected by mild cognitive impairment (MCI) exhibit characteristic voxel-mirrored homotopic connectivity (VMHC) alterations, the ability of such VMHC abnormalities to predict the diagnosis of MCI in these patients remains uncertain. As such, this study was performed to evaluate the potential role of VMHC abnormalities in the diagnosis of MCI.</p></div><div><h3>Methods</h3><p>MCI patients and healthy controls (HCs) were enrolled and subjected to resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing. VMHC and support vector machine (SVM) techniques were then used to examine the collected imaging data.</p></div><div><h3>Results</h3><p>Totally, 53 MCI patients and 68 healthy controls were recruited. Compared to HCs, MCI patients presented with an increase in postcentral gyrus VMHC. SVM classification demonstrated the ability of postcentral gyrus VMHC values to classify HCs and MCI patients with accuracy, sensitivity, and specificity values of 63.64 %, 71.69 %, and 89.71 %, respectively.</p></div><div><h3>Conclusion</h3><p>VMHC abnormalities in the postcentral gyrus may be mechanistically involved in the pathophysiological progression of MCI patients, and these abnormal VMHC patterns may also offer utility as a neuroimaging biomarker for MCI patient diagnosis.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112547"},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001931/pdfft?md5=704d55ad23f8ef48088378c84fc22442&pid=1-s2.0-S0531556524001931-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory and antioxidant effect of liposomal auraptene against cyclophosphamide-induced immunosuppression in BALB/c mice","authors":"Saeed Naseri ,&nbsp;Jinous Asgarpanah ,&nbsp;Seyed Ali Ziai","doi":"10.1016/j.exger.2024.112552","DOIUrl":"10.1016/j.exger.2024.112552","url":null,"abstract":"<div><h3>Introduction</h3><p>Cyclophosphamide (CP), which is a commonly used chemotherapy drug, can lead to a range of side effects such as immunosuppression, bone marrow suppression, leukopenia, and oxidative stress. This study aims to explore the effects of Auraptene (AUR), which has immunomodulatory and antioxidant properties, on immune function in mice that are experiencing suppression induced by CP.</p></div><div><h3>Materials and methods</h3><p>The experiment involved 60 male BALB/c mice that underwent a 10-day treatment. On days 1, 3, and 9, CP was given at 80 mg/kg IP doses to induce immunosuppression. The mice were divided into five groups: Control group, CP group, CP + liposomal AUR 0.2 mg/kg (AUR 0.2), CP + liposomal AUR 0.25 mg/kg (AUR 0.25), and liposomal vehicle group. Various parameters were measured, including mouse weight, immune organ weight index (spleen and thymus), spleen and thymus histopathology, levels of inflammatory cytokines (IL2, IL10, IL4, IFN-γ), TH1/TH2 balance ratio, IgG and IgM immunoglobulin levels, white blood cell count, platelets, neutrophils, lymphocytes, and oxidative activity measured by MDA, SOD, and Total Antioxidant.</p></div><div><h3>Results</h3><p>In the group treated with CP, the mice showed a significant decrease in weight compared to the control group. In contrast, the group treated with AUR maintained their weight and did not show a significant difference from the control group. AUR 0.25 reduced the damage to the spleen and thymus caused by CP. Additionally, AUR 0.25 demonstrated a significant decrease in IL4 and IL10 levels compared to the CP group (<em>p</em> = 0.04), approaching the levels of the control group. Furthermore, IL2 and IFN-γ levels in the AUR 0.25 group significantly increased (<em>p</em> = 0.04) compared to the CP group, reaching levels similar to the control group. AUR also increased serum IgM and IgG levels two to three times compared to the CP group, approaching the levels of the control group. MDA levels in the AUR 0.25 group decreased to normal and control levels. AUR 0.25 also showed increased SOD and Total Antioxidant levels. Additionally, white blood cells, platelets, neutrophils, and lymphocytes in the AUR group significantly increased compared to the CP group, reaching normal levels similar to the control group. The TH1/TH2 ratio in the AUR group exhibited a significant increase of two and a half times (<em>p</em> = 0.002) compared to the CP group.</p></div><div><h3>Conclusion</h3><p>These results show that AUR protects against the side effects of CP by increasing the function of the humoral and cellular immune system through the balance of TH1/TH2 and increasing the level of immunoglobulins, as well as increasing the antioxidant activity and the protective role of cytotoxicity.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112552"},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001980/pdfft?md5=ea91d8b82772d0ef3c483ff228864460&pid=1-s2.0-S0531556524001980-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of fibroblast autophagy and proliferation in skin anti-aging","authors":"Yantong Lu ,&nbsp;Guangjuan Pan ,&nbsp;Zhiying Wei ,&nbsp;Yaohua Li ,&nbsp;Xiaojiao Pan","doi":"10.1016/j.exger.2024.112559","DOIUrl":"10.1016/j.exger.2024.112559","url":null,"abstract":"<div><p>Skin, as the outermost protective barrier of the body, becomes damaged with age and exposure to external stimuli. Dermal fibroblasts age and undergo apoptosis, which decreases collagen, collagen fibers, elastic fibers, hyaluronic acid, etc., leading skin to loss of elasticity and appearance of wrinkles. Skin aging is complex, involving several biological reactions，and various treatment methods are used to treat it. This review focuses on the importance of autophagy and cell proliferation in skin anti-aging, summarizes research progress on skin anti-aging by regulating autophagy and promoting the proliferation of dermal fibroblasts, and discusses future directions on skin anti-aging research.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"196 ","pages":"Article 112559"},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002055/pdfft?md5=28802c786051570056d15cfafda31cd0&pid=1-s2.0-S0531556524002055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence","authors":"Limeiting Wang ,&nbsp;Jun Zhang ,&nbsp;Lu Liang ,&nbsp;Zijun Song ,&nbsp;Pinwen Wang ,&nbsp;Liya Ma ,&nbsp;Zhenhui Liao ,&nbsp;Ning Li ,&nbsp;Hefeng Yang ,&nbsp;Song Li","doi":"10.1016/j.exger.2024.112546","DOIUrl":"10.1016/j.exger.2024.112546","url":null,"abstract":"<div><p>Senescent chondrocytes or signaling mechanisms leading to senescence are promising new therapeutic approaches for ameliorating cartilage degradation. Herein, we show that the transactive response DNA/RNA-binding protein (TDP-43) regulates chondrocyte senescence and ameliorates cartilage degradation. First, a significant decrease in TDP-43 was observed in 16-month-old mice compared with younger mice. Immunohistochemistry (IHC) analysis of mouse articular cartilage showed that p21, p16, p53, and matrix metalloprotein-13 (MMP13) were increased, but laminB1 and Collagen type II alpha1 1 chain (Col2a1) were decreased in 16-month-old mice. Furthermore, TDP-43 levels were decreased <em>in vivo</em> following D-galactose (D-gal) induction. Therefore, we investigated the role of TDP-43 in the senescent chondrocytes. ATDC5 cells were induced to overexpress TDP-43. Western blot analysis showed increased expression of laminB1, Ki67, and PCNA but decreased expression of p21, p16, p53, and MMP13. Senescence-associated-β-galactosidase (SA-β-Gal) assay, γH2AX staining, and EdU were performed to assess changes in chondrocytes, showing weaker SA-β-Gal and γH2AX staining but stronger EdU and Alican Blue staining. However, TDP-43 deficiency had opposing effects, and similar to D-gal stimulation results. Taken together, our data verified that TDP-43 negatively correlated with senescence markers, positively correlated with cell proliferation markers, and could alleviate cartilage degradation induced by D-gal. This may be an essential mechanism of cellular senescence and cartilage degradation.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112546"},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S053155652400192X/pdfft?md5=a96b0944ef3f3f73dec29a12916fd0a8&pid=1-s2.0-S053155652400192X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosterols in mountain cultivated ginseng, as master healthy ageing dietary supplement, activates steroid signaling in ageing Drosophila melanogaster","authors":"Jialiang Liu ,&nbsp;Rui Ma ,&nbsp;Baoyu Fu ,&nbsp;Pengdi Yang ,&nbsp;Lili Zhang ,&nbsp;Chunyang Zhang ,&nbsp;Ying Chen ,&nbsp;Liwei Sun","doi":"10.1016/j.exger.2024.112554","DOIUrl":"10.1016/j.exger.2024.112554","url":null,"abstract":"<div><p>Mountain cultivated ginseng (MCG) is planted in mountain forests to simulate traditional wild ginseng; therefore, it has a greater pharmacological effect than cultivated ginseng (CG) in the garden; however, insufficient evidence confirms this theory. In light of the health-promoting and life-extending properties of ginseng, we analyzed the efficacy of MCG and CG. Initial observations revealed that the phytosterols content of MCG was higher than that of CG, with a positive correlation to the duration of growth. The distinction between phytosterols in MCG and in CG is predominately determined by the stigmasterol content using High-Performance Liquid Chromatography (HPLC). The lifespan of <em>Drosophila melanogaster</em> (fruit flies) that aged naturally was prolonged by phytosterols in MCG and CG and stigmasterols. Further, they prolonged healthy ageing as measured by progeny numbers, length of sleep, climbing distance, and survival following oxidative damage. The findings of behavioral observations revealed that phytosterols in MCG were more efficacious than in CG in promoting health maintenance and life extension; moreover, stigmasterol indicated that these effects were dose-dependent. Stigmasterols, phytosterols in MCG and CG have restored age-associated decreases in steroid hormone levels. Notably, molecular docking was predicted to promote stigmasterol's binding to the steroid hormone receptor ECR due to its similarity to steroid hormones. In addition, stigmasterols triggered the steroid hormone signaling pathway by increasing the activity of key genes <em>Eip75B</em> and <em>Br</em> in 20E signaling and <em>Jhamt</em>, <em>HmGR</em>, <em>Met</em>, and <em>Kr-h1</em> in JH signaling. Phytosterols, as a natural product, regulated health and longevity as a dietary supplement similar to that of steroids, which supported the social requirements of healthy ageing.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112554"},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524002006/pdfft?md5=7b94096b556cac2a08911beafe03497c&pid=1-s2.0-S0531556524002006-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of asthma with the risk of cardiovascular disease: A Mendelian randomization study","authors":"Shuang Han ,&nbsp;Xiao Wu ,&nbsp;Xiufa Peng ,&nbsp;Chunling Zhang","doi":"10.1016/j.exger.2024.112549","DOIUrl":"10.1016/j.exger.2024.112549","url":null,"abstract":"<div><h3>Background</h3><p>Association of asthma with the risk of cardiovascular disease has not been fully elucidated. So, this study tried to explore the genetic effect of asthma on five cardiovascular diseases and 90 peripheral cardiovascular proteins to answer the above topic.</p></div><div><h3>Methods</h3><p>Instrumental variables predicting asthma was extracted from its genome-wide association study data. Two-sample and multivariate MR approaches were used to assess the genetic association of exposure factor (i.e., asthma) with outcome factors (i.e., hypertension, atrial fibrillation, angina pectoris, myocardial infarction, heart failure, and 90 peripheral cardiovascular proteins).</p></div><div><h3>Results</h3><p>First, asthma nominally increased the risk of hypertension and atrial fibrillation (OR = 1.009, 95%CI = 1.003–1.016, <em>P</em> = 0.004; OR = 1.074, 95%CI = 1.024–1.127, <em>P</em> = 0.003). Second, of the 90 cardiovascular proteins, asthma was associated with the increased levels of tumor necrosis factor ligand superfamily member 14 and C<img>C motif chemokine 4 (β = 0.145, 95%CI = 0.077–0.212, <em>P</em> = 2.936e-05; β = 0.128, 95%CI = 0.063–0.193, <em>P</em> = 1.036e-04). Third, C<img>C motif chemokine 4 increased the risk of hypertension (<em>P</em> = 0.043); and after adjusting for this protein, asthma still increased the risk of hypertension, but the strength of its <em>P</em>-value changed from 0.004 to 0.011.</p></div><div><h3>Conclusion</h3><p>Asthma was a risk factor for hypertension and atrial fibrillation at the genetic level, and C<img>C motif chemokine 4 might play a mediating role in the mechanism by which asthma promoted hypertension. Thus, effective control of asthma may help reduce the risk of some cardiovascular diseases in older adults.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112549"},"PeriodicalIF":3.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001955/pdfft?md5=bba00354128e634d0917993928d5a3f2&pid=1-s2.0-S0531556524001955-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the causal relationship between frailty and sex hormone-binding globulin or insulin-like growth factor-1 levels: A sex-stratified bidirectional Mendelian Randomization study","authors":"Xinying Fan ,&nbsp;Yuxin Wang ,&nbsp;Zhaoyu Zhang ,&nbsp;Runjun Yang ,&nbsp;Yajing Zhou ,&nbsp;Jie Gu","doi":"10.1016/j.exger.2024.112545","DOIUrl":"10.1016/j.exger.2024.112545","url":null,"abstract":"<div><h3>Background</h3><p>The association between frailty and sex hormone-binding globulin (SHBG) or insulin-like growth factor-1(IGF-1) levels demonstrates sex differences with inconsistent conclusions. This study aims to explore the causal relationship between frailty and SHBG or IGF-1 levels through bidirectional Mendelian randomization (MR).</p></div><div><h3>Methods</h3><p>We conducted two-sample bidirectional sex-stratified MR analyses using summary-level data from genome-wide association studies (GWASs) to examine the causal relationship between frailty and IGF-1 or SHBG levels, as measured by frailty index (FI) and frailty phenotype (FP). We use the random-effects inverse-variance weighted (IVW), weighted median, MR-Egger, MR-Egger intercept, and leave-one-out approaches.</p></div><div><h3>Result</h3><p>The relationship between frailty and SHBG or IGF-1 levels is inversely related, with a significant decrease in SHBG levels in females. Specifically, SHBG levels significantly decrease with FI (β = −5.49; 95 % CI: −9.67 to −1.32; FDR = 0.02) and more pronounced with FP (β = −10.14; 95 % CI: −16.16 to −4.13; FDR = 0.01), as determined by the IVW approach. However, reverse analysis shows no significant effect of IGF-1 or SHBG levels on either FI or FP (<em>p</em> &gt; 0.05).</p></div><div><h3>Conclusion</h3><p>Our study indicates a negative correlation between frailty and the levels of SHBG and IGF-1. It is suggested that further research is required to establish cut-off values for SHBG and IGF-1 levels in the frailty population. This is particularly important for females at higher risk, such as those undergoing menopause, to enable comprehensive assessment and early prevention efforts. While the findings imply that reduced IGF-1 and SHBG levels may not directly contribute to frailty, it is important not to overlook the underlying mechanisms through which they may indirectly influence frailty.</p></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"195 ","pages":"Article 112545"},"PeriodicalIF":3.9,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0531556524001918/pdfft?md5=0e8c7d20fecf4184c34e66b3dfea6dc8&pid=1-s2.0-S0531556524001918-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}