Experimental gerontology最新文献

{"title":"Verbal training can improve neurocognitive and reading performance by increasing white matter integrity and grey matter volume","authors":"Ching-Chi Hsu ,&nbsp;Yun-Hsiang Wu ,&nbsp;Kang-Shuo Lee ,&nbsp;Po-Cheng Shih ,&nbsp;Tzu-Yu Liu ,&nbsp;James Cheng-Chung Wei ,&nbsp;Wei-Min Chu ,&nbsp;Toshiharu Nakai ,&nbsp;Fan-Pei Gloria Yang","doi":"10.1016/j.exger.2024.112625","DOIUrl":"10.1016/j.exger.2024.112625","url":null,"abstract":"<div><h3>Introduction</h3><div>Dementia and mild cognitive impairment (MCI) present both health and economic challenges on a global scale, thus affecting millions of people, and is projected to increase significantly by the year 2050. Early language processing deficits are evident in those diagnosed with Alzheimer's disease and MCI. Recent advances in pharmacologic and non-pharmacologic interventions, including cognitive rehabilitation and training, show promising effects on cognitive functions. Articulation training, particularly, is highlighted for its potential in addressing the communication difficulties which those experiencing dementia and MCI face, based on the transmission deficit hypothesis. This study aimed to perform a voxel-wise comparison of morphological changes in grey matter volume as well as white matter integrity to represent the plastic changes in response to articulation training among older, healthy Japanese adults.</div></div><div><h3>Methods</h3><div>Forty older, healthy Japanese adults were randomized into either a cognitive training group or a control group. The study involved comprehensive behavioral assessments, neuroimaging (including 3D anatomy, fMRI and Diffusion Tensor Imaging), and a structured verbal articulation training regimen. The training included reading tasks which focused on enhancing both articulation and phonological skills. Neuroimaging data were acquired using a 3 Tesla Siemens MR scanner, with the FSL tool being used for white matter analysis and the CAT12 toolbox for grey matter analysis.</div></div><div><h3>Results</h3><div>Significant increases in grey matter volume were observed in certain regions, including the left Supplementary motor area, Postcentral gyrus, and bilateral Superior frontal gyrus among those in the training group. Correlations were noted between reading abilities and cortical volume in areas such as the left Middle temporal gyrus, pulvinar, and Middle occipital gyrus. White matter integrity also improved, as evidenced by increased fractional anisotropy in tracts such as the superior longitudinal fasciculus, corona radiata, and internal capsule. These findings suggest a link between articulation training and enhanced neuroplasticity in both grey and white matter regions related to language processing.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that a 4-week verbal articulation training intervention period can lead to significant improvements in grey matter volume in the left Supplementary motor area, the left Postcentral gyrus, and the bilateral Superior frontal gyrus, as well as the integrity of white matter tracts associated with language processing among older adults. These results suggest that such training could be a valuable tool in enhancing cognitive functions related to language in older populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112625"},"PeriodicalIF":3.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of home-based exercise alone or combined with cognitive training on cognition in community-dwelling older adults: A randomized clinical trial","authors":"Emma Gabrielle Dupuy ,&nbsp;Florent Besnier ,&nbsp;Christine Gagnon ,&nbsp;Thomas Vincent ,&nbsp;Tudor Vrinceanu ,&nbsp;Caroll-Ann Blanchette ,&nbsp;Jeremy Gervais ,&nbsp;Juliana Breton ,&nbsp;Kathia Saillant ,&nbsp;Josep Iglesies-Grau ,&nbsp;Sylvie Belleville ,&nbsp;Martin Juneau ,&nbsp;Paolo Vitali ,&nbsp;Anil Nigam ,&nbsp;Mathieu Gayda ,&nbsp;Louis Bherer","doi":"10.1016/j.exger.2024.112628","DOIUrl":"10.1016/j.exger.2024.112628","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Structured and supervised physical exercise and cognitive training are two efficient ways to enhance cognition in older adults. Performing both within a combined intervention could maximize their effect on cognition due to their potential synergy on brain functions. During the COVID-19 pandemic, these interventions were particularly relevant due to the collateral impact of social restrictions regarding physical activity and the level of cognitive stimulation. However, the benefits of remotely monitored intervention combining physical exercise and cognitive training for older adult cognition remain to be demonstrated.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;127 older adults (age: 65.20 ± 7.95) were randomized in two arms, encouraging self-engagement in six months of home-based physical exercise alone or combined with cognitive training, monitored by phone once a week. Neuropsychological assessment was performed under videoconference supervision at baseline and after three and six months. Composite &lt;em&gt;Z&lt;/em&gt;-scores were calculated for processing speed, executive functioning, working, and episodic memory to assess changes after three and six months of training. The weekly metabolic expenditure of self-reported activities was estimated using the compendium of physical activity to distinguish participants performing higher and lower doses of exercise (median split).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;106 participants (83.46 %) completed the 6-month training. Results showed a greater &lt;em&gt;Z&lt;/em&gt;-score change in executive functioning for participants in the combined arm than those who only exercised (F = 4.127, &lt;em&gt;p&lt;/em&gt; = 0.046, η&lt;sub&gt;p&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.050). Group x Exercise dose interaction was observed for episodic memory Z-score change (F = 6.736, &lt;em&gt;p&lt;/em&gt; = 0.011, η&lt;sub&gt;p&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.070), with a greater improvement for participants performing higher doses of exercise compared to those who performed a lower dose, only in exercise alone arm. Performing a higher dose of exercise increased the working memory &lt;em&gt;Z&lt;/em&gt;-score change in both intervention arms compared to a lower dose (F = 7.391, &lt;em&gt;p&lt;/em&gt; = 0.008, η &lt;sub&gt;p&lt;/sub&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.076).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Remote combined training may lead to larger improvement in executive functioning than exercise alone. Physical exercise showed a dose-related improvement in working and episodic memory performances. The combination of cognitive interventions mitigated the effects of exercise on episodic memory. These results suggest that home-based exercise and cognitive training may help improve older adults' cognition.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Trial registration&lt;/h3&gt;&lt;div&gt;COVEPIC was retrospectively registered on December 03, 2020. Clinical trials Identifier: &lt;span&gt;&lt;span&gt;NCT04635462&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt; - &lt;span&gt;&lt;span&gt;https://clinicaltrials.gov/ct2/show/record/NCT04635462?term=NCT04635462&amp;draw=2&amp;rank=1&lt;/span&gt;&lt;svg&gt;&lt;pat","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112628"},"PeriodicalIF":3.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non pharmacoligical approaches for neurodegenerative diseases: A narrative review","authors":"Muhammad Liaquat Raza ,&nbsp;Areej Bhojani ,&nbsp;Syeda Kashaf Batool ,&nbsp;Dua Zehra","doi":"10.1016/j.exger.2024.112620","DOIUrl":"10.1016/j.exger.2024.112620","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112620"},"PeriodicalIF":3.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: A systematic review and meta-analysis","authors":"Henrique Monteiro Lapo ,&nbsp;Amanda Veiga Sardeli ,&nbsp;Lilian Oliveira Mariano ,&nbsp;Fiona Jayne Howroyd ,&nbsp;Paulo Roberto Sokoll ,&nbsp;Elizabeth Sapey ,&nbsp;Mara Patrícia Traina Chacon-Mikahil","doi":"10.1016/j.exger.2024.112617","DOIUrl":"10.1016/j.exger.2024.112617","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.</div></div><div><h3>Methods</h3><div>A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.</div></div><div><h3>Results</h3><div>At admission, higher functionality was significantly higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], <em>P</em> ≤ 0.001), with greatest effect in the patients &gt;70 years (2.84 [1.74, 3.93], <em>P</em> = 0.006), compared to their counterparts.</div></div><div><h3>Conclusion</h3><div>Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.</div></div><div><h3>Protocol registration</h3><div>PROSPERO CRD42021278619.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112617"},"PeriodicalIF":3.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of epicardial adipose tissue volume measured in diagnosis and prognosis of patients with HFPEF","authors":"Yunlu Jiang ,&nbsp;Li Su","doi":"10.1016/j.exger.2024.112618","DOIUrl":"10.1016/j.exger.2024.112618","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112618"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of spleen tyrosine kinase (SYK) contributes to neuronal pyroptosis and cognitive impairment in diabetic mice via the NLRP3/Caspase-1/GSDMD signaling pathway","authors":"Chenglong Zhou ,&nbsp;Jun Li ,&nbsp;Xiaochu Wu ,&nbsp;Fei Liu","doi":"10.1016/j.exger.2024.112626","DOIUrl":"10.1016/j.exger.2024.112626","url":null,"abstract":"<div><h3>Background/aim</h3><div>Diabetes mellitus (DM) patients are at increased risk of cognitive impairment. The precise mechanisms underlying the association between DM and cognitive impairment remain unclear. Spleen tyrosine kinase (SYK), a crucial regulator of signal transduction, has been implicated in microglial pyroptosis in experimental ischemic stroke models. The present study investigated the potential role of SYK in DM-associated cognitive impairment.</div></div><div><h3>Methods</h3><div>Diabetes was induced by streptozotocin (STZ) in C57BL/6 mice, and cognitive function and cerebral injury were assessed 12 weeks later using the Morris water maze (MWM), TUNEL assay and Western blotting. In vitro, the inhibition of SYK was investigated in a mouse hippocampal neuronal cell line cultured with high glucose.</div></div><div><h3>Results</h3><div>Compared with control mice, DM mice presented impaired spatial learning and memory. Additionally, SYK activation was linked to neuronal pyroptosis, as evidenced by increases in the number of TUNEL-positive cells and protein levels of NLRP3, ASC, procaspase-1, caspase-1, GSDMD, the GSDMD N-terminal fragment, pro-IL-1β, and IL-1β in the hippocampus of DM mice. Compared with no treatment, SYK knockdown markedly attenuated cognitive impairment and histologic and ultrastructural pathological changes in the hippocampus of DM mice. The increased expression of pyroptosis-associated proteins and the increased number of TUNEL-positive cells were also significantly reduced. In vitro, high glucose significantly activated SYK to trigger the canonical pyroptotic pathway in cultured HT22 cells. The inhibition of SYK with a small interfering RNA or specific inhibitor significantly ameliorated the neuronal pyroptosis mediated by high glucose.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that SYK activation plays a pivotal role in promoting the cognitive impairment associated with DM. This effect is mediated by triggering neuronal pyroptosis through the canonical NLRP3/Caspase-1/GSDMD pathway. These results suggest that SYK may serve as a potential target for preventing or mitigating cognitive impairment in patients with DM.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112626"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of different tree densities on alpha waves, physical activity enjoyment, and satisfaction of late middle-aged and older adults using virtual cycling.","authors":"Ta-Wei Tang, Tsai-Chiao Wang, Chia-Liang Tsai","doi":"10.1016/j.exger.2024.112608","DOIUrl":"10.1016/j.exger.2024.112608","url":null,"abstract":"<p><p>Cave automatic virtual environment (CAVE), as a novel approach to promoting physical activity, shows great potential for improving the mental health and healthy lifestyle of older adults. Based on stress reduction theory, tree density is regarded as a main characteristic of a virtual sportscape that will affect the experience and benefits of exercising. However, the effect of tree density on the experience of exercising remains unclear. The current study was undertaken to investigate the effects of tree cover density on the alpha waves induced and the enjoyment and satisfaction derived by engaging in physical activity in a virtual environment. Eighty-seven late middle-aged and older adults were randomly assigned to one of the following conditions: a high tree density sportscape (HTDS = 36-60 %), a medium tree density sportscape, (MTDS = 20-35 %), and a control condition. Questionnaires and electroencephalogram read-outs of alpha waves were used to evaluate the changes in stress levels experienced by the participants before, during, and after 20 min of cycling. The results showed that participants exposed to an HTDS exhibited to physical activity with significantly more enjoyment and satisfaction than those in the MTDS and control groups. In contrast, the highest degree of relaxation was exhibited in the MTDS condition, suggesting that an MTDS is more effective at reducing perceived stress among late middle-aged and older adults engaging in virtual cycling. These findings demonstrate that exercising in a virtual reality setting with different densities of tree cover comes with physiological and psychological wellbeing for late middle-aged and older adults.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":" ","pages":"112608"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High glucose-induced senescence contributes to tubular epithelial cell damage in diabetic nephropathy.","authors":"Deping Xu, Puseletso Moru, Kainan Liao, Wei Song, Ping Yang, Dandan Zang, Chunlin Cai, Haisheng Zhou","doi":"10.1016/j.exger.2024.112609","DOIUrl":"10.1016/j.exger.2024.112609","url":null,"abstract":"<p><p>Dysfunctional renal tubular epithelial cells, induced by high glucose, are commonly observed in the kidney tissues of diabetic nephropathy (DN) patients. The epithelial-mesenchymal transition (EMT) of these cells often leads to renal interstitial fibrosis and kidney damage in DN. High glucose also triggers mitochondrial damage and apoptosis, contributing further to the dysfunction of renal tubular epithelial cells. Cellular senescence, a recognized characteristic of DN, is primarily caused by high glucose. However, it remains unclear whether high glucose-induced cellular senescence in DN exacerbates the functional impairment of tubular epithelial cells. In this study, we examined the relationship between EMT and cellular senescence in kidney tissues from streptozotocin (STZ)-induced DN and HK-2 cells treated with high glucose (HG). We also investigated the impact of HG concentrations on tubular epithelial cells, specifically mitochondrial dysfunction, cellular senescence and apoptosis. These damages were primarily associated with the secretion of cytokines (such as IL-6, and TNF-α), production of reactive oxygen species (ROS), and an increase of intracellular Ca²⁺. Notably, resveratrol, an anti-aging agent, could effectively attenuate the occurrence of EMT, mitochondrial dysfunction, and apoptosis induced by HG. Mechanistically, anti-aging treatment leads to a reduction in cytokine secretion, ROS production, and intracellular Ca²⁺ levels.</p>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"112609"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biological roots of the sex-frailty paradox","authors":"Beatrice Arosio ,&nbsp;Anna Picca","doi":"10.1016/j.exger.2024.112619","DOIUrl":"10.1016/j.exger.2024.112619","url":null,"abstract":"<div><div>Aging is a dynamic process that requires a continuous response and adaptation to internal and external stimuli over the life course. This eventually results in people aging differently and women aging differently than men. The “gender paradox” describes how women experience greater longevity than men, although linked with higher rates of disability and poor health status.</div><div>Recently, the concept of frailty has been incorporated into this paradox giving rise to the “sex-frailty paradox” which describes how women are frailer because they manifest worse health status but, at the same time, appear less susceptible to death than men of the same age. However, very little is known about the biological roots of this sex-related difference in frailty.</div><div>Inflamm-aging, the chronic low-grade inflammatory state associated with age, plays a key pathophysiological role in several age-related diseases/conditions, including Alzheimer's disease (AD), for which women have a higher lifetime risk than men. Interestingly, inflamm-aging develops at a different rate in women compared to men, with features that could play a critical role in the development of AD in women.</div><div>According to this view, a continuum between aging and age-related diseases that probably lacks clear boundaries can be envisioned in which several shared biological mechanisms that progress at different pace may lead to different aging trajectories in women than in men. It, therefore, becomes urgent to consider a holistic approach in the study of aging, and decline it from a gender medicine perspective also considering the biological roots of the sex-frailty paradox.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112619"},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythms and objective measures of physical activity among middle-aged and older adults in Taiwan","authors":"Jia-Chian Hu ,&nbsp;Szu-Yu Hou ,&nbsp;Jeanne L. Shea ,&nbsp;Hsiao-Han Tang ,&nbsp;Sheng-Fu Liang ,&nbsp;Yu-Ching Hsu ,&nbsp;Ching-Ju Chiu","doi":"10.1016/j.exger.2024.112616","DOIUrl":"10.1016/j.exger.2024.112616","url":null,"abstract":"<div><h3>Background</h3><div>To identify the association between daytime activity with objectively monitor and subjective variables at a different time-zone of day as well as the sex differences.</div></div><div><h3>Methods</h3><div>Participants aged 50 years and older living in the community in Taiwan were recruited. The activity was measured by wearable actigraphy devices, diaries, and self-reported questionnaires. The study used nonparametric analysis to examine the association between mean activity level and demographic and subjective measurement variables.</div></div><div><h3>Results</h3><div>Among the 55 participants enrolled in the study, data of 34 (62 %) participants who meet the criteria that wore a wearable actigraphy device for at least 7 completed days were analyzed. There is no significant relationship between each demographics and subjective measurement variables. However, actigraphy counts are significantly related to female's nutrition (Z = -2.367, <em>p</em> = 0.017*), and male's retirement status (Z = -2.132, <em>p</em> = 0.033*).</div></div><div><h3>Conclusions</h3><div>The activity in morning is highest of the day with significant correlation to evening activities. Moreover, actigraphy counts that indicating objective measure of physical activity in female is significantly related to physiological variables (nutritional status), while male are predicted by social variables (retired status).</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"198 ","pages":"Article 112616"},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}