Experimental gerontology最新文献

{"title":"Immune cell–associated DNA methylation responses to exercise in women: A bioinformatics analysis comparing pre- and postmenopausal stages","authors":"Guilherme da Silva Rodrigues ,&nbsp;Natalia Yumi Noronha ,&nbsp;Andressa Crystine da Silva Sobrinho ,&nbsp;Bernadette Jones-Freeman ,&nbsp;Robin Grolaux ,&nbsp;Camila Fernanda Cunha Brandao ,&nbsp;Julio Sergio Marchini ,&nbsp;Lígia Moriguchi Watanabe ,&nbsp;Carla Barbosa Nonino ,&nbsp;Andrew Teschendorff ,&nbsp;Nir Eynon ,&nbsp;Carlos Roberto Bueno Júnior ,&nbsp;Macsue Jacques","doi":"10.1016/j.exger.2025.112996","DOIUrl":"10.1016/j.exger.2025.112996","url":null,"abstract":"<div><h3>Introduction</h3><div>Menopause is associated with immunosenescence and altered immune profiles, potentially reducing immune competence. Physical exercise may counteract these changes by modulating DNA methylation in fitness-related genes.</div></div><div><h3>Methods</h3><div>This observational bioinformatics study analyzed genome-wide DNA methylation profiles derived from whole blood using two publicly available datasets from Brazilian cohorts (Illumina MethylationEPIC 850K). The analysis included pre- (PreM, <em>n</em> = 13; 34 ± 4.7 years) and postmenopausal (PostM, <em>n</em> = 49; 59.8 ± 4.7 years) women who completed supervised combined exercise training. Four linear models were applied to examine associations between DNA methylation, cardiorespiratory fitness (VO₂ peak), and exercise intervention (pre- vs. post-training), while adjusting for age, fat percentage, and estimated immune-cell proportions (EpiDISH). Interaction terms were tested to assess whether immune cell composition or menopausal status modulated the relationship between VO₂ peak, exercise response, and DNA methylation.</div></div><div><h3>Results</h3><div>After adjusting for baseline values using analysis of covariance (ANCOVA), no statistically significant between-group differences were observed in the estimated immune cell proportions (FDR &gt; 0.05). In PostM, exercise-induced DNA methylation changes were significantly associated with baseline VO₂ peak and were modulated by B cells, CD4⁺ T cells, NK cells, and monocytes. Functional enrichment highlighted pathways involved in lipid kinase regulation, nucleobase metabolism, and membrane organization.</div></div><div><h3>Conclusion</h3><div>Postmenopausal women showed distinct epigenetic patterns in response to exercise, although these differences must be interpreted cautiously given the small premenopausal sample size. These results suggest potential immune cell–associated DNA methylation markers to inform personalized exercise strategies supporting healthy aging in women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 112996"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning for cognitive impairment screening: Development and external validation of a clinical prediction model based on NHANES data","authors":"Kang Chen ,&nbsp;Guran Yu ,&nbsp;Hao Li","doi":"10.1016/j.exger.2025.113019","DOIUrl":"10.1016/j.exger.2025.113019","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairment in older adults poses a growing public health challenge, yet accessible screening tools remain limited. We aimed to develop and validate an interpretable machine learning model for cognitive impairment prediction by routinely collecting clinical data.</div></div><div><h3>Methods</h3><div>We analyzed 1061 participants from the U.S. National Health and Nutrition Examination Survey (NHANES 2011–2014). Feature selection combined multivariable regression, restricted cubic splines, and the Boruta algorithm to identify 40 clinical, demographic, and socioeconomic variables. Twelve machine learning models (including Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), and Random Forest (RF)) were trained and externally validated on NHANES 2001–2002 (<em>n</em> = 531). Model performance was evaluated by area under the receiver operating characteristic curve (AUC-ROC), calibration (Brier score), accuracy, and sensitivity. Additionally, an assessment of fairness was conducted across racial subgroups. Interpretability was enhanced via SHapley Additive exPlanations (SHAP).</div></div><div><h3>Results</h3><div>The SVM model demonstrated optimal generalizability, achieving an external validation AUC of 0.8265 (95 %CI: 0.7867–0.8582) with sustained calibration (Brier score = 0.1703). Subgroup analyses showed no statistically significant AUC differences (all <em>P</em> &gt; 0.05). SHAP analysis identified socioeconomic factors, systemic inflammation indices, and metabolic markers as key predictors.</div><div>Limitations.</div><div>Generalizability may be limited to U.S. populations, and unmeasured biomarkers (e.g., amyloid-β) could affect prediction accuracy. Subgroup analyses for minorities were constrained by sample size.</div></div><div><h3>Conclusion</h3><div>Our interpretable prediction strategy enables rapid cognitive risk assessment using routine clinical data, providing a cost-effective decision support tool adaptable to electronic health record systems.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113019"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probucol attenuates bone loss in APP/PS1 mice and ameliorates Aβ42-induced osteoblast dysfunction by regulating AKT/FOXO3a signaling pathway","authors":"Dong Liu ,&nbsp;Hongyan Yang ,&nbsp;Xiangqian Feng ,&nbsp;Mingliang Hou ,&nbsp;Xiaoyan Fu ,&nbsp;Xiaoxiong Li ,&nbsp;Wenjuan Hong ,&nbsp;Le Chen ,&nbsp;Jinping Li ,&nbsp;Linqiu Ma ,&nbsp;Qirong Liao ,&nbsp;Yating Liu ,&nbsp;Jing Lu ,&nbsp;Donglin Wang ,&nbsp;Huadong Zhou ,&nbsp;Rui Zhou","doi":"10.1016/j.exger.2026.113034","DOIUrl":"10.1016/j.exger.2026.113034","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) and osteoporosis are common age-related degenerative diseases. Emerging evidence suggests that amyloid-β (Aβ) deposition may contribute to the pathogenesis of both conditions. This study investigated whether probucol could alleviate AD-associated bone loss and Aβ42-induced osteoblast dysfunction, and further explored the underlying mechanisms.</div></div><div><h3>Methods</h3><div>Female mice were divided into four groups (<em>n</em> = 5 per group): C57BL/6 wild-type (WT), WT treated with probucol (WT + PBC), APP/PS1 transgenic (AD) mice, and AD treated with probucol (AD+PBC). Bone mineral density (BMD) was assessed by micro-CT. Levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) along with bone metabolism markers including fibroblast growth factor 23 (FGF23), sclerostin, and brain-derived neurotrophic factor (BDNF) in bone and brain tissues were measured by ELISA. FOXO3a was knocked down in the bone marrow of APP/PS1 mice via stereotactic injection of lentiviral vectors. Expression of APP and FOXO3a in bone tissue was evaluated using RT-qPCR and Western blotting (WB). Mitochondrial damage in osteoblasts and neuronal cells was assessed by transmission electron microscopy (TEM). In vitro study, osteoblast differentiation and mineralization deficits were evaluated using Alizarin Red staining. WB was used to measure the expression of AKT, FOXO3a, autophagy and apoptosis related proteins.</div></div><div><h3>Results</h3><div>Probucol attenuated bone loss and mitochondrial damage in both APP/PS1 and FOXO3a-knockdown APP/PS1 mice, and improved cognitive impairment and neuronal ultrastructure in APP/PS1 mice. Furthermore, probucol attenuated Aβ42-induced osteoblast differentiation and mineralization via the AKT/FOXO3a signaling pathway in vitro.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that probucol ameliorates AD-associated bone loss and Aβ42-induced osteoblast impairments by regulating AKT/FOXO3a signaling pathway.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113034"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sensory afferences in postural control quantified by force platform in healthy older adults: Systematic review and meta-analysis","authors":"J. Aflalo ,&nbsp;C. Truong ,&nbsp;A. Nicolaï ,&nbsp;L. Gouzer ,&nbsp;B. Morisset ,&nbsp;F. Bertin-Hugault ,&nbsp;D. Ricard ,&nbsp;F. Quijoux","doi":"10.1016/j.exger.2025.112976","DOIUrl":"10.1016/j.exger.2025.112976","url":null,"abstract":"<div><div>Postural balance in older adults is a key research focus, as impaired balance significantly increases fall risk, potentially leading to severe injury or mortality. Given age-related sensory decline, force-platform posturography assessing sensory perturbation effects could elucidate postural control deficits in aging. This systematic review and meta-analysis examines older adults' ability to maintain quiet stance during sensory perturbations.</div><div>We searched 8 databases for studies evaluating older adults' balance under various sensory conditions.</div><div>We included 64 articles in this review, for a total number of 4481 subjects. Proprioceptive and visual afferences were the most explored. Meta-analyses were conducted when several studies shared similar procedures and domain analysis for older adults (OA), older fallers (OF), and young adults (YA). They showed a significant impact of visual deprivation on older adults' balance for positional, dynamic and frequential variables, while it was significant only in the positional and dynamic domains for younger adults. When proprioception was disturbed, all the meta-analyses showed a significant impact on older adults.</div><div>We concluded that positional and dynamic variables are sensitive to sensory perturbations and therefore could be useful in geriatric balance assessment. However, we emphasize the variability in methodological approaches and reporting standards, which constrains the broader applicability of these findings. We posit that posturographic research requires standardization and the establishment of an expert consensus regarding clinically relevant variables to facilitate the integration of posturography into geriatric fall risk assessment protocols, preventive programs and rehabilitation care.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112976"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145610421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of neutrophil-percentage-to-albumin ratio in the association between stroke and heart failure among U.S. adults","authors":"Yan Zhao ,&nbsp;Tingting Chen ,&nbsp;Conghua Ji ,&nbsp;Yuxin Shang ,&nbsp;Yuqing Pan ,&nbsp;Wei Mao","doi":"10.1016/j.exger.2025.113010","DOIUrl":"10.1016/j.exger.2025.113010","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is an independent risk factor for heart failure (HF), and they are both linked to systemic inflammation. The neutrophil-percentage-to-albumin ratio (NPAR) is a novel inflammation biomarker. However, it is unclear whether the NPAR mediates the relationship between stroke and HF.</div></div><div><h3>Methods</h3><div>We analyzed data from 42,101 adults in the NHANES. Multivariable regression models adjusted for confounders were used to assess associations of stroke with NPAR and HF. Restricted cubic spline (RCS) curves were employed to investigate potential non-linear or linear relationships between NPAR and HF. Furthermore, mediation analysis was performed to assess the potential mediating role of NPAR.</div></div><div><h3>Results</h3><div>NPAR levels of participants with HF and/or stroke were higher than those without HF and stroke (<em>P</em> &lt; 0.0001). Following full adjustment, stroke was positively associated with NPAR (β = 0.421, 95 % CI = 0.242, 0.600, <em>P</em> &lt; 0.0001), with stronger associations noted in females (interaction β = 0.450, interaction <em>p</em>-value &lt; 0.001). Similarly, stroke was positively associated with HF (OR = 3.0301, 95 % CI = 2.4143, 3.8030, <em>P</em> &lt; 0.0001). RCS analysis further revealed a nonlinear correlation between NPAR and HF. Furthermore, mediation analysis revealed that NPAR significantly mediated the relationship between stroke and HF (proportion mediated = 3.58 %, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>This study identified that stroke and NPAR are significantly related to HF, which increases the risk of HF in the adults, and the mediating role of NPAR is significant in the relationship between stroke and HF. This finding highlights the necessity of regulating the inflammatory-nutritional.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113010"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145807078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepcidin inhibits osteoclast differentiation to alleviate osteoporosis by modulating the p53/miR-34a/Trem2 axis","authors":"Lujun Chen ,&nbsp;Guiwen Liu ,&nbsp;Sheng Liu ,&nbsp;Yin Zhu ,&nbsp;Zhongrui Liu ,&nbsp;Luliang Wei ,&nbsp;Yuzhen Liao ,&nbsp;Yongjun Ye ,&nbsp;Weimin Huang ,&nbsp;Wuyang Liu ,&nbsp;Lulin Liu","doi":"10.1016/j.exger.2025.112994","DOIUrl":"10.1016/j.exger.2025.112994","url":null,"abstract":"<div><h3>Background</h3><div>The relationship between iron accumulation and osteoporosis (OP) progression has received attention in recent years. Hepcidin is a key regulator of iron homeostasis and may contribute to the treatment of OP. However, the underlying molecular mechanism of hepcidin in OP remains unclear.</div></div><div><h3>Methods</h3><div>Transgenic mice were constructed, including hepcidin overexpression (Hamp) mice and Trem2 overexpression (Trem2) mice, followed by performed ovariectomy (OVX) procedure. Trem2-OVX mice and Hamp mice were used to construct parabiosis model, which was named as Hamp+Trem2-OVX parabiosis mice. Serum hepcidin and ferritin levels were tested by ELISA. Bone microstructure and related parameters were evaluated by Micro-CT. Bone mass and osteoclast ratio in mice were assessed by tartrate-resistant acid phosphatase (TRAP) staining and hematoxylin and eosin staining. Bone marrow-derived macrophages (BMMs) were isolated from OVX mice and Hamp-OVX mice, and then treated with RANKL to induce osteoclast differentiation. Osteoclast formation and differentiation were assessed by TRAP staining, western blot and immunofluorescence staining assay. The protein levels of osteoclast differentiation-related markers, p53 and Trem2 were examined by western blot. Quantitative real-time PCR was used to measure miR-34a and Trem2 mRNA expression. The interaction between miR-34a and p53 or Trem2 was confirmed by ChIP assay, dual-luciferase reporter assay and RIP assay.</div></div><div><h3>Results</h3><div>Serum hepcidin level was decreased in OP women and mice, and its overexpression attenuated OP progression in OVX mice. Hepcidin overexpression inhibited osteoclast formation and differentiation in RANKL-induced BMMs. Hepcidin activated p53 to promote miR-34a transcription, and miR-34a targeted Trem2. Inhibition of miR-34a reversed the inhibitory effect of hepcidin on osteoclast formation and differentiation in RANKL-induced BMMs. Furthermore, Trem2 overexpression promoted bone loss and osteoclast formation in OVX mice, and these effects were abolished in Hamp+Trem2-OVX parabiosis mice.</div></div><div><h3>Conclusion</h3><div>Hepcidin alleviated OP progression by inhibiting osteoclast differentiation <em>via</em> regulating the p53/miR-34a/Trem2 axis.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112994"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of videoconference-supervised exercise training program on physical and cognitive conditions, and mental well-being in older adults: A randomized trial","authors":"E. Milot ,&nbsp;A. Langeard ,&nbsp;S. Rehel ,&nbsp;E. Gökçe ,&nbsp;D.-C. Navarro-Morales ,&nbsp;M. Bagueneau ,&nbsp;L. Vincent ,&nbsp;N. Bessot ,&nbsp;G. Quarck","doi":"10.1016/j.exger.2025.112990","DOIUrl":"10.1016/j.exger.2025.112990","url":null,"abstract":"<div><div>Aging is associated with declines in physical, cognitive, and physical and mental well-being. This randomized trial aimed to assess the effects of a supervised, home-based multicomponent physical training program delivered via videoconferencing on physical fitness, cognitive performance, and mental well-being in healthy older adults. Thirty participants aged 60–70 years completed either a physical training intervention (PT), a health education intervention (active control, AC), or no intervention (passive control, PC) over a period of 12 weeks. Physical fitness (daily movements, handgrip, knee extension, peak oxygen consumption, timed up and go, and balance), cognition (stroop, trail making tests, dual-task performance), and mental well-being (short form 36 item questionnaire, geriatrics depression scale, anxiety scales) were assessed pre- and post-intervention. The intervention demonstrated high adherence, supporting the feasibility and acceptability of remote exercise programs. Results showed no significant improvements in physical fitness across groups. However, only the PT group demonstrated significant improvements in mental well-being, whereas depressive symptoms decreased similarly across all groups. Cognitive improvements in executive functions were observed across groups, and dual-task performance improved specifically in the PT and AC groups. While limited by small sample size, these findings suggest that supervised videoconferencing-based exercise is a promising, accessible strategy that could improve mental well-being and promote fitness and cognitive functioning in older adults. Further research is needed among larger and more diverse populations.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112990"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145737546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between food inflammation scores of individuals and sarcopenia in U.S. adults: A cross-sectional study from NHANES 2011–2018","authors":"Li Tao ,&nbsp;Qinghuan Yang ,&nbsp;Xinrong Zeng ,&nbsp;Hao Yu ,&nbsp;Jun Mu ,&nbsp;Zhiwen Yan ,&nbsp;Yinghong Tang","doi":"10.1016/j.exger.2025.113004","DOIUrl":"10.1016/j.exger.2025.113004","url":null,"abstract":"<div><div>This cross-sectional study investigates the association between the Food Inflammation Scores of Individuals (FISI34, FISI26-USDA, FISI26-CHINA), derived from the Food Inflammation Index (FII), and sarcopenia in 5489 U.S. adults from the National Health and Nutrition Examination Survey (NHANES 2011–2018). Sarcopenia was defined using appendicular lean mass adjusted for body mass index (BMI). Logistic regression and restricted cubic spline analyses revealed significant positive associations between higher FISI and sarcopenia prevalence, with odds ratios ranging from 1.13 to 1.39 in fully adjusted models. Stronger associations were observed in females, adults aged ≥40 years, Mexican Americans, and those with higher BMI or chronic conditions like hypertension and cardiovascular disease, though no significant interaction effects were observed (p-interaction &gt;0.05). FISI, incorporating individual dietary intake and nutrient reference values, offers a personalized approach compared to the Dietary Inflammatory Index (DII), supporting the evaluation of targeted dietary strategies to address sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113004"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomous fall risk assessment in Australian Residential Aged Care Facilities using passive sensors: A feasibility study","authors":"David Silvera-Tawil ,&nbsp;Jane Li ,&nbsp;Liesel Higgins ,&nbsp;Deepa Prabhu ,&nbsp;Jennifer Hewitt ,&nbsp;Katie Packer ,&nbsp;Wei Lu ,&nbsp;Maggie Haertsch ,&nbsp;Marlien Varnfield","doi":"10.1016/j.exger.2025.113013","DOIUrl":"10.1016/j.exger.2025.113013","url":null,"abstract":"<div><h3>Background</h3><div>Falls in residential aged care home (RAC) remain a critical issue in Australia, contributing to diminished quality of life and increased morbidity among older adults. This study investigates the feasibility of passive sensor technologies to proactively identify behavioural changes, such as reduced mobility and sleep disturbances, that may signal elevated fall risk. It also explores resident and staff acceptance of the technology.</div></div><div><h3>Methods</h3><div>An open-label, non-randomized feasibility trial using a single-group, post-test mixed methods design was conducted with 24 residents at a RAC in Sydney, Australia. Ambient and wearable sensor data and clinical records were collected, alongside interviews with residents and staff. Data were analysed using quantitative and qualitative techniques to assess feasibility and user experience.</div></div><div><h3>Results</h3><div>Sensor data revealed diverse resident routines and rapid staff responses to alerts. Predictive analytics showed promise for identifying elevated fall risk, though further validation is needed. Qualitative feedback from 10 residents indicated residents found the system mostly unobtrusive but raised concerns around privacy and false alerts that triggered staff interventions. Despite this, many residents acknowledged its value, especially for individuals with higher vulnerability. Interviews with eight staff members echoed the system's potential to enhance monitoring and safety, but noted technical and training challenges.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that sensor-based monitoring in RACs is technically feasible and generally acceptable. The findings support its integration into aged care as a proactive, person-centred approach to falls management, provided that implementation is supported by thoughtful design, clear communication, and staff training.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 113013"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper-to-zinc ratio predicts incident sarcopenia and adverse health outcomes: Results from I-Lan Longitudinal Aging Study","authors":"Kuan-Yu Peng ,&nbsp;Wei-Ju Lee ,&nbsp;Chih-Kuang Liang ,&nbsp;Li-Ning Peng ,&nbsp;Ming-Hsien Lin ,&nbsp;Ching-Hui Loh ,&nbsp;Fei-Yuan Hsiao ,&nbsp;Liang-Kung Chen","doi":"10.1016/j.exger.2025.112984","DOIUrl":"10.1016/j.exger.2025.112984","url":null,"abstract":"<div><h3>Introduction</h3><div>The copper-to‑zinc (Cu/Zn) ratio is linked to inflammation and aging, but longitudinal evidence for sarcopenia remains limited. We examined associations of serum copper (Cu), zinc (Zn), and Cu/Zn ratio with adverse health outcomes and sarcopenia.</div></div><div><h3>Methods</h3><div>Cu, Zn, and the Cu/Zn ratio were analyzed as continuous variables and by tertiles. The study included (1) a 5-year survival analysis assessing associations with adverse outcomes (falls, hospital admissions, emergency department visits, mortality, and a composite outcome); and (2) cross-sectional and 3-year longitudinal analysis examining their associations with prevalent and incident sarcopenia. Sarcopenia was defined based on the Asian Working Group for Sarcopenia 2019 criteria.</div></div><div><h3>Results</h3><div>Over five years, 357 of 2015 participants experienced adverse events; 311 of 1474 non-sarcopenic participants developed incident sarcopenia over three years. Each standard deviation increase in the Cu/Zn ratio was associated with higher risks of adverse outcomes (aHR 1.18, 95 % CI 1.04–1.33, <em>p</em> = 0.008), hospitalization (aHR 1.23, 95 % CI 1.02–1.49, <em>p</em> = 0.030), mortality (aHR 1.50, 95 % CI 1.06–2.13, <em>p</em> = 0.021), and incident sarcopenia (aOR 1.39, 95 % CI 1.13–1.73, <em>p</em> &lt; 0.001). Higher Cu levels predicted low muscle mass (aOR 1.18, 95 % CI 1.05–1.33, <em>p</em> = 0.005), while higher Zn levels were protective against muscle weakness (aOR 0.84, 95 % CI 0.73–0.97, <em>p</em> = 0.015). Importantly, the association between the Cu/Zn ratio and incident sarcopenia remained significant after additional adjustment for cardiometabolic risk factors and inflammatory biomarkers.</div></div><div><h3>Conclusions</h3><div>Elevated serum Cu/Zn ratio predicts adverse outcomes and sarcopenia, highlighting its value as a biomarker for clinical risk in older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"213 ","pages":"Article 112984"},"PeriodicalIF":4.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}