Experimental gerontology最新文献

{"title":"Epstein-Barr virus and the origin of frailty and fatigue: A two-sample multivariable bidirectional Mendelian randomization study","authors":"Jie Li ,&nbsp;Tailin Chen","doi":"10.1016/j.exger.2025.112860","DOIUrl":"10.1016/j.exger.2025.112860","url":null,"abstract":"<div><h3>Background</h3><div>The causal relationship between Epstein-Barr virus (EBV) infection and frailty or fatigue remains unclear, despite evidence linking chronic inflammation to these conditions.</div></div><div><h3>Methods</h3><div>This study utilized a two-sample Mendelian Randomization (MR) framework to investigate the causal relationship between EBV infection and the development of frailty and fatigue. The outcomes assessed were frailty, defined by the Frailty Index (FI), and fatigue, measured through Chronic Fatigue Syndrome (CFS), Malaise and Fatigue (MF), while EBV infection was represented by anti-EBV IgG seropositivity, antibody levels, and a history of infectious mononucleosis. Genetic variants strongly associated with EBV exposure were identified and used as instrumental variables (IVs). Two-sample MR analyses were conducted using the Inverse Variance Weighted (IVW) method, and multivariable MR (MVMR) was applied to adjust for potential confounding, including age. Reverse MR analyses were also performed to explore reverse causality. Sensitivity analyses, including horizontal pleiotropy and leave-one-out tests, were carried out to assess the reliability of the results.</div></div><div><h3>Results</h3><div>A total of 9 GWAS were used to derive summary data for EBV-related exposures and frailty/fatigue outcomes. In multivariable MR, EBV ZEBRA antibody levels were significantly associated with an increased FI score (aβ = 0.026; 95 % CI 0.006, 0.046; <em>P</em> = 0.011) after age adjustment. EBV EA-D showed a significant link with CFS in unadjusted models, but lost significance after age adjustment. EBV VCA p18 and EA-D were associated with MF, with significance remaining for EBV VCA p18 (aOR = 1.25; 95 % CI: 1.01, 1.57; <em>P</em> = 0.046) and EA-D (aOR = 1.38; 95 % CI: 1.00, 1.90; <em>P</em> = 0.049) after age adjustment. The reverse MR analysis revealed negative associations between MF and EBNA-1/ZEBRA antibodies. Sensitivity analyses confirmed robustness with no evidence of pleiotropy or heterogeneity. Secondary analysis further supported the causal associations.</div></div><div><h3>Conclusion</h3><div>EBV infection demonstrates causal links to frailty and fatigue, mediated through specific antibody responses. These findings emphasize EBV's role in chronic inflammatory pathways and highlight potential targets for clinical intervention.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112860"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of physical activity and hydration markers with cellular health in older adults: A doubly labeled water study","authors":"Kan Oishi ,&nbsp;Tsukasa Yoshida ,&nbsp;Hyeon-Ki Kim ,&nbsp;Keiichi Yokoyama ,&nbsp;Yuya Watanabe ,&nbsp;Yui Nakayama ,&nbsp;Misaka Kimura ,&nbsp;Kojiro Ishii ,&nbsp;Rei Ono ,&nbsp;Yosuke Yamada","doi":"10.1016/j.exger.2025.112859","DOIUrl":"10.1016/j.exger.2025.112859","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to determine the associations between the phase angle (PhA), extracellular water-to-intracellular water ratio (ECW/ICW), physical activity levels (PALs) measured using the doubly labeled water (DLW) method, and the time spent engaging in physical activities of varying intensities in older adults living in Japan.</div></div><div><h3>Methods</h3><div>This study was part of the Kyoto–Kameoka prospective cohort study of older adults. The PhA and ECW/ICW ratio were measured using a multi-frequency bioelectrical impedance analysis device. PAL, percentage body fat, and fat-free mass index were calculated using the DLW method, while the average daily moderate-to-vigorous physical activity (MVPA), high-intensity light physical activity (HLPA), low-intensity light physical activity, and sedentary behavior durations were quantified using a triaxial accelerometer.</div></div><div><h3>Results</h3><div>Adjusted partial order correlation analysis showed significant positive correlations between the PhA and PAL (<em>p</em> = 0.001), as well as between the PhA and the MVPA (<em>p</em> = 0.027) and HLPA (<em>p</em> = 0.023) durations. The PAL was also significantly negatively correlated with the ECW/ICW ratio (<em>p</em> = 0.008). Adjusted multiple regression analysis confirmed that PAL (<em>p</em> = 0.004) and HLPA (<em>p</em> = 0.025) were significantly positively associated with PhA and negatively associated with ECW/ICW ratio (p = 0.004 and <em>p</em> = 0.036, respectively).</div></div><div><h3>Conclusions</h3><div>PAL, measured using the precise DLW method, is an explanatory factor for PhA and ECW/ICW ratio. HLPA below the MVPA threshold was linked to more favorable hydration markers of cellular health in older adults. As this was a cross-sectional study, causality cannot be inferred.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112859"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-response associations of accelerometer-measured physical activity with mortality across frailty levels: A prospective cohort study","authors":"Qunyong Peng ,&nbsp;Tianqi Ma ,&nbsp;Lingfang He ,&nbsp;Xunjie Cheng ,&nbsp;Wei Xie","doi":"10.1016/j.exger.2025.112858","DOIUrl":"10.1016/j.exger.2025.112858","url":null,"abstract":"<div><h3>Background</h3><div>Limited evidence, majorly based on questionnaire-derived measurements, was available to reflect long-term benefits of physical activity (PA) across different frailty levels.</div></div><div><h3>Methods</h3><div>We included 81,219 UK Biobank participants (mean age 61.88 years; 41.2 % men) with accelerometer data. Participants were categorized using frailty phenotype as robust, prefrail, and frail. Restricted cubic splines described the associations of continuous light intensity PA (LPA), moderate/vigorous intensity PA (MVPA), and total PA (TPA) levels with all-cause mortality. Adjusted hazard ratios (HRs) of outcomes by multi-categorical LPA and MVPA levels were estimated. Further joint analyses were performed if significant interaction existed between PAs and frailty.</div></div><div><h3>Results</h3><div>Of the included participants, 54,081 (66.6 %) were robust and 1071 (1.3 %) were frail. Over a median follow-up of 10.68 years, 3825 (4.7 %) deaths occurred. For all-cause mortality, L-shaped nonlinear associations existed for LPA, MVPA, and TPA. Compared with &lt;150 min/week, MVPA of 150–300, 300–600, and ≥600 min/week-related HRs were 0.57 (0.48–0.68), 0.39 (0.33–0.46), and 0.30 (0.25–0.36) for robust and 0.37 (0.23–0.58), 0.32 (0.20–0.53), and 0.18 (0.07–0.48) for frail people, respectively. MVPA-related associations were modified by frailty (<em>P</em>_{<em>interaction</em>} = 0.007). In joint analyses, compared with robust people with highest MVPA level, frail patients with MVPA &lt;150 min/week had ~6 times higher risk of mortality, while those with frailty but MVPA ≥150 min/week had a relatively lower mortality risk than robust people with MVPA &lt;150 min/week.</div></div><div><h3>Conclusion</h3><div>Dose-response associations existed between device-measured PA levels and mortality risk across different frailty levels. Frail patients benefited greater via MVPA engagement, which partially attenuated frailty-related excessive risk.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112858"},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between body roundness index with femoral neck bone mineral density, osteoporosis, and FRAX score in middle-aged and older adults: A cross-sectional study","authors":"Wentao Xiao ,&nbsp;Yi Wang ,&nbsp;Taichuan Xu ,&nbsp;Chao Li ,&nbsp;Xian Zhang","doi":"10.1016/j.exger.2025.112848","DOIUrl":"10.1016/j.exger.2025.112848","url":null,"abstract":"<div><h3>Background</h3><div>The clinical usefulness of the body roundness index (BRI) in predicting bone health outcomes, including femoral neck bone mineral density (FN BMD), osteoporosis, and fracture risk assessment (FRAX) scores, remains unvalidated in middle-aged and elderly populations.</div></div><div><h3>Methods</h3><div>Based on NHANES data from 2013 to 2014, we included 2215 adults. Weighted multiple linear regression and logistic regression models were used to investigate the relationship between BRI and FN BMD, osteoporosis, and FRAX scores. Non-linear correlations were examined using the restricted cubic spline (RCS) model.</div></div><div><h3>Results</h3><div>The regression analyses indicated a robust positive correlation between BRI and FN BMD, with each unit boost in BRI leading to a 0.018 g/cm² increase in FN BMD (β = 0.018, 95 %CI: 0.015, 0.021). A substantial negative association was found between BRI and osteoporosis (OR = 0.804, 95 %CI: 0.714, 0.906). Furthermore, the BRI was significantly and negatively associated with FRAX scores. RCS revealed a linear positive correlation between BRI and FN BMD and a negative linear correlation with osteoporosis and a negative non-linear correlation with FRAX scores.</div></div><div><h3>Conclusion</h3><div>This cross-sectional study elucidated that the BRI demonstrates a complex relationship with various bone health parameters, including a significant positive correlation with FN BMD and a significant negative correlation with osteoporosis prevalence and FRAX scores. However, it was unable to establish a causal relationship between the BRI and these various bone health parameters.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112848"},"PeriodicalIF":4.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length in sleep disorders","authors":"Gülüstan Eşel ,&nbsp;Özlem Olguner Eker ,&nbsp;Ayaz Amraliyev ,&nbsp;Akif Asdemir ,&nbsp;Elif Özge Biçer ,&nbsp;Damla Badur Mermer ,&nbsp;Munis Dündar ,&nbsp;Ertuğrul Eşel ,&nbsp;Sevda İsmailoğulları","doi":"10.1016/j.exger.2025.112851","DOIUrl":"10.1016/j.exger.2025.112851","url":null,"abstract":"<div><h3>Background</h3><div>Sleep and circadian rhythms are affected by aging. Although the relationship between sleep disorders and cellular aging has been demonstrated in some studies, it still remains unclear. Telomere length has been considered one of the sensitive biomarkers for aging in recent years. Studies investigating the relationship between sleep disorders and telomere length are limited and their results are inconsistent. This study aims to demonstrate telomere length in sleep disorders.</div></div><div><h3>Methods</h3><div>The study sample consisted of 116 participants, 94 patients and 22 healthy participants. Patients groups comprised diagnosed with narcolepsy (<em>N</em> = 31), insomnia (<em>N</em> = 20), Restless Legs Syndrome (RLS) (<em>N</em> = 21), and Obstructive Sleep Apnea Syndrome (OSAS) (<em>N</em> = 22) according to ICSD-3 diagnostic criteria. All participants were aged between 18‐55 and had no tobacco, alcohol, or substance dependence. Telomere lengths of the participants were measured using the rtPCR method.</div></div><div><h3>Results</h3><div>When telomere lengths were compared across groups, no significant differences were observed between the healthy controls and any of the patient groups. However, among the patient groups, individuals with insomnia had significantly shorter telomere lengths compared to those with RLS (<em>p</em> = 0.014) and OSAS (<em>p</em> = 0.012) (F = 4.405; <em>p</em> = 0.002).</div></div><div><h3>Conclusions</h3><div>The finding that patients with insomnia exhibited shorter telomeres than those with RLS and OSAS suggests that insomnia may present a higher risk for age-related diseases and accelerated aging processes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112851"},"PeriodicalIF":4.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of home-based slow-paced breathing on functional performance in middle-aged women: A randomized controlled trial study","authors":"Karama Masmoudi ,&nbsp;Fatma Chaari ,&nbsp;Haithem Rebai ,&nbsp;Sonia Sahli","doi":"10.1016/j.exger.2025.112854","DOIUrl":"10.1016/j.exger.2025.112854","url":null,"abstract":"<div><div>As individuals age, functional performance declines, particularly affecting mobility, strength, and postural balance, with middle-aged women experiencing earlier and more pronounced impairments due to menopausal transition. Given the low adherence to traditional exercise programs among this population, home-based slow-paced breathing (SPB) presents a promising accessible alternative. Hence, this study aimed to examine the effects of a 12-week daily SPB intervention on functional performance in middle-aged women.</div><div>Twenty-six middle-aged women were randomized into an experimental group (EG), which practiced home-based SPB, or a control group (CG), which continued their usual activities. Static postural balance, upper- and lower-limb muscle strength, mobility and dynamic balance, and aerobic endurance were evaluated at pre-intervention, post-4, post-8, and post-12 weeks of intervention.</div><div>Static postural balance improved on a firm surface within the EG post-12 weeks of intervention, though no significant differences emerged between groups. On a foam surface, improvements emerged post-8 weeks in the eyes-open condition and post-4 weeks in the eyes-closed condition. Additionally, aerobic endurance improved within the EG post-8 weeks, with no significant differences between groups. No significant group x session interactions were found for other functional performances.</div><div>These findings indicate that middle-aged women who practiced or not the SPB demonstrated similar functional outcomes, suggesting that SPB alone may not be sufficient to induce significant improvements in functional performances. Exploring the effects of integrating SPB with muscle-strengthening exercises or neuromuscular training could be interesting to determine whether a combined approach could yield greater functional benefits and address the limitations of the observed non-significant results.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112854"},"PeriodicalIF":4.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between visceral fat accumulation and sarcopenia: A cross-sectional study","authors":"Shengwei Wang ,&nbsp;Weigen Wu ,&nbsp;Ling Zhang ,&nbsp;Qi Zeng ,&nbsp;Yu Luo ,&nbsp;Weiwen He ,&nbsp;Wei Chen ,&nbsp;Wen He","doi":"10.1016/j.exger.2025.112849","DOIUrl":"10.1016/j.exger.2025.112849","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of sarcopenia is increasing annually, and tools for assessing its risk remain limited. Visceral fat accumulation is closely associated with sarcopenia.</div></div><div><h3>Methods</h3><div>Data from 5200 participants in NHANES 2011–2018 were analyzed. Six visceral fat accumulation indicators, namely relative fat mass (RFM), lipid accumulation product (LAP), weight-adjusted waist index (WWI), triglyceride glucose-waist-to-height ratio (TyG-WHtR), metabolic score for insulin resistance (METS-IR), and metabolic score for visceral fat (METS-VF), were evaluated and compared for their associations with sarcopenia using multivariable logistic regression, smoothed curve fitting and threshold effect analysis. This study aimed to develop nine machine learning (ML) models incorporating visceral fat indicators to predict the risk of sarcopenia, with Shapley Additive Explanations (SHAP) applied to enhance model interpretability.</div></div><div><h3>Results</h3><div>Visceral fat accumulation indicators were substantially associated with the risk of sarcopenia. Threshold effect analysis revealed that the saturation points for RFM, LAP, WWI, TyG-WHtR, METS-IR, and METS-VF in sarcopenia were 41.844, 76.747, 11.352, 4.777, 50.525, and 6.806, respectively. The logistic regression model exhibited the highest predictive performance with an area under the receiver operating characteristic curve (AUC-ROC) of 0.878. WWI was identified as the strongest predictor of sarcopenia risk in the SHAP analysis.</div></div><div><h3>Conclusion</h3><div>All visceral fat accumulation indicators were positively associated with sarcopenia risk and WWI identified as the most important predictor. The ML model achieved high predictive accuracy, highlighting the role of visceral fat accumulation in sarcopenia risk and healthy aging promotion.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112849"},"PeriodicalIF":4.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of different frailty assessment tools in older patients undergoing major abdominal surgery","authors":"Junli You ,&nbsp;Xuepiao Chen ,&nbsp;Yu Rong ,&nbsp;Sining Pan ,&nbsp;Tianxiao Liu ,&nbsp;Yubo Xie","doi":"10.1016/j.exger.2025.112852","DOIUrl":"10.1016/j.exger.2025.112852","url":null,"abstract":"<div><h3>Background</h3><div>Multiple frailty assessment tools are available for clinical practice, but the optimal tool remains unclear. This study aimed to compare the diagnostic performance of frail scale (FS), frailty phenotype (FP),11-item modified frailty index (mFI-11), Edmonton Frail Scale (EFS), and Tilburg Frailty Indicator (TFI) for frailty taking the comprehensive geriatric assessment (CGA) as the gold standard, and their ability to predict 30-day postoperative complications and prolonged length of stay (PLOS).</div></div><div><h3>Methods</h3><div>This study recruited older patients (≥ 65 years) undergoing elective major abdominal surgery. The receiver operating characteristic (ROC) curves, technique for order preference by similarity to ideal solution (TOPSIS), and decision analysis curve (DCA) were used to validate the diagnostic, comprehensive, and predictive performance of 5 tools in frailty, complications, and PLOS.</div></div><div><h3>Results</h3><div>EFS presented moderate consistency with CGA (Kappa = 0.544, <em>P</em> &lt; 0.001), excellent performance in diagnosing frailty (area under the ROC curve (AUC) = 0.881, <em>P</em> &lt; 0.001), and high clinical net benefit within the risk threshold ranging from 0.8 % to 57.44 %. Although EFS had the largest AUC for predicting complications (AUC = 0.612) and PLOS (AUC = 0.642) and showed high clinical net benefit, its predictive performance was poor (AUC &lt; 0.7). The TOPSIS indicated that EFS required optimization in multiple aspects (closeness coefficient (Ci) &lt; 0.8).</div></div><div><h3>Conclusion</h3><div>EFS has excellent diagnostic performance and clinical net benefit for frailty. However, further research is required to identify optimal tools or combine EFS with additional indicators to enhance its comprehensive and predictive performance for complications and PLOS.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112852"},"PeriodicalIF":4.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acute response of irisin to resistance and endurance exercise at both lower and higher intensities in healthy older adults","authors":"James E. Newman ,&nbsp;Isabel King ,&nbsp;Nicole Flemming ,&nbsp;Kathryn M. Broadhouse ,&nbsp;Robert Buhmann ,&nbsp;Grace L. Rose ,&nbsp;David G. Jenkins ,&nbsp;Christopher D. Askew ,&nbsp;Mia A. Schaumberg","doi":"10.1016/j.exger.2025.112850","DOIUrl":"10.1016/j.exger.2025.112850","url":null,"abstract":"<div><div>Exercise-induced release of irisin may contribute to the beneficial effects of exercise on brain health. Previous studies in healthy adults have shown ~15 % increase in short-term post-exercise irisin concentrations. However, previous research investigating the exercise-induced release of irisin in older populations is scarce and findings are highly variable. The present study investigated the effects of exercise mode and intensity on short-term acute post-exercise irisin concentrations in older adults. Thirty-two healthy older adults (women n = 18, men n = 14, age 72 ± 5 years), completed a randomised cross over study of four single-bout exercise sessions on separate days, consisting of either: lower-intensity resistance exercise (Low-RE), higher-intensity resistance exercise (High-RE), lower-intensity endurance exercise (Low-EE) or higher-intensity endurance exercise (High-EE) as well as a seated rest control (RC). Serum irisin concentrations were measured at pre- and 0-, 30-, and 60-min post-exercise. Body composition, peak oxygen consumption and one repetition maximum were evaluated to inform individual exercise intensities. Irisin concentrations were increased immediately after High-RE, High-EE, and Low-EE and remained elevated after Low-EE at 30 min post-exercise. Irisin concentrations were greater after Low-EE than High-EE at 30-min post-exercise, and greater after High-RE than Low-RE at 60-min post-exercise. Healthy older adults exhibit a short-term acute peak irisin response to exercise (~17 %) comparable to that previously observed in younger populations (~15 %), highlighting the potential for exercise-induced benefits on brain health irrespective of age. Given that resistance and endurance exercises at different intensities elicit distinct responses, intensity, resistance volume, endurance session duration and mode must be considered when designing optimal exercise prescriptions for improved brain health.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112850"},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and assessment of an early diagnostic approach for painful diabetic peripheral neuropathy using basic clinical and laboratory parameters","authors":"Yue Yang ,&nbsp;Lu Liu ,&nbsp;Hui-Hui Wang ,&nbsp;Yan Lu ,&nbsp;Jiang-Ping Li ,&nbsp;Ping Liu ,&nbsp;Zi-Cheng Hu ,&nbsp;Xiao Yang","doi":"10.1016/j.exger.2025.112847","DOIUrl":"10.1016/j.exger.2025.112847","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study is to construct a predictive model for the onset of painful diabetic peripheral neuropathy (PDPN) in patients with diabetic peripheral neuropathy (DPN).</div></div><div><h3>Methods</h3><div>The clinical and laboratory data of 783 patients with DPN were retrospectively analyzed to form the modeling group. A Douleur Neuropathique 4 score of ≥4 was used to identify neuropathic pain (NP), and such patients were categorized into the PDPN group. Potential predictive variables were screened using least absolute shrinkage and selection operator (LASSO) regression. Logistic regression was subsequently used to construct a predictive model for PDPN. The discriminatory power and calibration of the model were assessed using receiver operator characteristic (ROC) curve analysis and calibration plots. For validation, the model was tested on an independent group of 350 patients with DPN.</div></div><div><h3>Results</h3><div>The final modeling and validation groups comprised of 359 and 162 patients with PDPN, respectively. The inclusion of five clinical variables resulted in an optimal predictive model: hemoglobin A1c (HbA1c) (odds ratio [OR] = 1.173, P &lt; 0.001), triglycerides (TG) (OR = 1.813, P &lt; 0.001), body mass index (BMI) (OR = 1.081, P = 0.002), disease duration (OR = 1.066, P &lt; 0.001), and 24-hour urine microalbumin (UMA) (OR = 1.003, P &lt; 0.001). The areas under the ROC curve for the modeling and validation groups were 0.812 and 0.850, respectively. The calibration plot demonstrated a close fit between the calibration curve and the ideal curve, with Hosmer–Lemeshow P values of 0.4153 for the modeling group and 0.8413 for the validation group.</div></div><div><h3>Conclusion</h3><div>These findings indicate that our nomogram can effectively predict the occurrence of PDPN in patients with DPN, thereby assisting clinicians in identifying patients at risk.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112847"},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}