Experimental gerontology最新文献

{"title":"Cognitive impairment as a mediator between sarcopenic obesity and independence in older adults","authors":"Isnaria Rizki Hayati , Rikas Saputra , Yenni Lidyawati","doi":"10.1016/j.exger.2025.112870","DOIUrl":"10.1016/j.exger.2025.112870","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112870"},"PeriodicalIF":4.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive aerobic exercise in reducing inflammation and oxidative stress markers in older adult Korean women with obesity","authors":"Suhan Koh ,&nbsp;Taekyu Kim ,&nbsp;Seonyoung Son ,&nbsp;Minkyo Kim ,&nbsp;Doyeon Kim","doi":"10.1016/j.exger.2025.112868","DOIUrl":"10.1016/j.exger.2025.112868","url":null,"abstract":"<div><h3>Background/objectives</h3><div>South Korea is rapidly transitioning into a super-aged society, where women not only outnumber men, but also have longer life expectancy. However, older adult women in Korea engage in significantly less regular physical activity than their male counterparts. This study aimed to examine the physiological mechanisms through which a 16-week progressive aerobic exercise program affected chronic inflammation and oxidative stress associated with aging in older adult women with obesity.</div></div><div><h3>Methods</h3><div>We randomly assigned 28 women aged ≥70 years with obesity to either an obesity exercise group (OEG) or an obesity control group (OCG). The OEG participated in a supervised aerobic exercise program three times per week for 16 weeks, with intensity progressively increasing. To analyze the effects of the intervention over time and between groups, a two-way repeated-measures ANOVA was conducted. Within-group comparisons across time points were performed using paired <em>t</em>-tests, and between-group comparisons at each time point were analyzed using independent <em>t</em>-tests.</div></div><div><h3>Results</h3><div>The OEG demonstrated a greater reduction in serum chemotactic chemokine biomarker CCL11 concentration than the OCG. The pattern was consistent across participants, suggesting that regular, progressively intensified aerobic exercise may help suppress pro-inflammatory chemokine expression, particularly that of CCL11, in older adult women with obesity.</div></div><div><h3>Conclusions</h3><div>A 16-week program of progressive aerobic exercise effectively reduced systemic inflammation and oxidative stress in older adult women with obesity, while potentially enhancing antioxidant defense. CCL11 reduction may reflect anti-inflammatory adaptations and potential neuroprotective benefits. These findings support aerobic exercise as a non-pharmacological strategy to manage age-related physiological decline.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112868"},"PeriodicalIF":4.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between changes in frailty status and non-neoplastic digestive system diseases: A cohort study based on the China health and retirement longitudinal study","authors":"Jingwei Che ,&nbsp;Qiao Song ,&nbsp;Chunyu Zhao ,&nbsp;Yuan Yuan ,&nbsp;Xiaohua Lyu","doi":"10.1016/j.exger.2025.112861","DOIUrl":"10.1016/j.exger.2025.112861","url":null,"abstract":"<div><h3>Background</h3><div>While prior studies have linked baseline frailty to specific non-neoplastic digestive diseases (NNDSD), the impact of frailty status transitions remains understudied.</div></div><div><h3>Method</h3><div>Participants were sourced from the China Health and Retirement Longitudinal Study (CHARLS) and categorized as robust, pre-frail, or frail using a frailty index comprising 32 health deficits with thresholds of 0.10 and 0.25. The frailty status at initial follow-up served as the baseline, and transitions were assessed using changes between the first and second follow-ups. NNDSD was defined based on patients' self-reports of whether a physician diagnosed them with a relevant disease. Associations between baseline frailty status, frailty transitions and NNDSD were assessed using Cox proportional hazards modeling. Finally, multiple sensitivity analyses were performed to validate result robustness.</div></div><div><h3>Results</h3><div>A total of 6994 participants (41 % women) were included in the baseline. Participants classified as pre-frail (hazard ratio [HR]: 1.55, 95 % confidence interval [CI]: 1.38–1.75) and frail (HR: 2.39, 95 % CI: 1.99–2.89) exhibited elevated NNDSD incidence. The final sample comprised 5299 participants (41 % women). Progression to pre-frail (HR: 1.64, 95 % CI: 1.30–2.10) and frail (HR: 2.91, 95 % CI: 1.72–4.90) was associated with NNDSD risk relative to participants who remained robust. Progression from pre-frail to frail (HR: 1.39 95 % CI: 1.08–1.81) elevated the risk of NNDSD onset. Recovery from pre-frail to robust (HR: 0.73, 95 % CI: 0.57–0.94) was associated with reduced NNDSD risk, with sensitivity findings corroborating study robustness.</div></div><div><h3>Conclusions</h3><div>Changes in frailty status were positively associated with new-onset NNDSD risk. Frailty progression corresponded to elevated risk, whereas reversal was linked to risk reduction.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112861"},"PeriodicalIF":4.3,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of resistance training on osteosarcopenia in community-dwelling postmenopausal Korean women: Randomised controlled ERTO-K trial","authors":"Byung Chan Lee ,&nbsp;Kyung Il Kim ,&nbsp;Juhyun Lee ,&nbsp;Kang Hee Cho ,&nbsp;Changwon Moon","doi":"10.1016/j.exger.2025.112869","DOIUrl":"10.1016/j.exger.2025.112869","url":null,"abstract":"<div><h3>Objective</h3><div>We evaluated the efficacy of a 6-month progressive resistance exercise in postmenopausal women with osteosarcopenia.</div></div><div><h3>Study design</h3><div>Thirty-four community-dwelling postmenopausal women with osteosarcopenia were randomly assigned to either a resistance exercise group (RE; <em>n</em> = 17) or a home exercise group (HE; n = 17). Both groups received home exercise brochures and nutritional supplementation. The RE group additionally participated in supervised resistance training sessions twice weekly.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was the change in the skeletal muscle index (SMI) and bone mineral density (BMD). The secondary outcomes included changes in handgrip strength (HGS) and physical performance.</div></div><div><h3>Results</h3><div>Seventeen and sixteen participants in the RE and HE groups, respectively, completed the intervention. The RE group showed significantly greater SMI improvement at the 12-week follow-up (0.310 ± 0.343 kg/m² vs. 0.011 ± 0.423 kg/m² in HE). However, there was no significant difference between groups at the 24-week follow-up. The other primary outcome, BMD, did not show any statistically significant differences either within or between groups. While both groups showed significant improvement in HGS and physical performance over time, the RE group had significantly higher HGS at the 6-week and 18-week follow-ups.</div></div><div><h3>Conclusions</h3><div>A 6-month program of progressive resistance exercise combined with nutritional support improved muscle mass and strength in postmenopausal women with osteosarcopenia. Although the HE group showed less improvement at earlier time points, their muscle strength and physical performance were comparable to those of the RE group by the end of the intervention.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112869"},"PeriodicalIF":4.3,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of body roundness index, serum α-Klotho and osteoarthritis: A nationwide population-based study of middle-aged and older adults","authors":"Wentian Gao ,&nbsp;Yu Zhang ,&nbsp;Yuejian Ding ,&nbsp;Qiangqiang Li ,&nbsp;Qing Jiang ,&nbsp;Dongyang Chen","doi":"10.1016/j.exger.2025.112873","DOIUrl":"10.1016/j.exger.2025.112873","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has identified associations between the body roundness index (BRI), a novel marker of abdominal obesity, and serum α-Klotho levels with osteoarthritis (OA). However, the interplay between BRI, α-Klotho and OA has been understudied. We aimed to investigate the association between BRI and OA, as well as the potential mediating role of α-Klotho in the bidirectional relationships between BRI and OA among middle-aged and older adults</div></div><div><h3>Methods</h3><div>This study enrolled 8275 participants from the National Health and Nutrition Examination Survey (NHANES). Weighted logistic regressions and restricted cubic splines were utilized to assess the relationships between BRI, α-Klotho, and OA. Subgroup analyses, interaction effects, and mediation analyses were also conducted</div></div><div><h3>Results</h3><div>After adjusting for all covariates, higher BRI was associated with lower odds of OA (OR = 1.40, 95 % CI: 1.29 to 1.52, <em>P</em> &lt; 0.001), whereas lower α-Klotho corresponded to higher odds of OA incidence (OR = 0.90, 95 % CI: 0.83 to 0.97, <em>P</em> = 0.009). Moreover, BRI was negatively correlated with serum α-Klotho (β = −0.045, <em>P</em> &lt; 0.001). Notably, α-Klotho partially mediated the relationship between BRI and OA (mediation proportion: 1.46 %, <em>P</em> = 0.004), as well as the relationship between OA and BRI (mediation proportion: 1.56 %, <em>P</em> = 0.001)</div></div><div><h3>Conclusion</h3><div>The associations between higher BRI and lower α-Klotho levels among individuals with OA was observed. These findings contribute to a better understanding of the bidirectional associations between BRI, α-Klotho levels, and OA among middle-aged and older adults, which may help inform future hypothesis-driven or mechanistic studies</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112873"},"PeriodicalIF":4.3,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary elementomic analysis indicates aluminum as a potential urinary biomarker of sarcopenia in the older adults","authors":"Mei-Lin Li ,&nbsp;Yi-Min Li ,&nbsp;Jing-Jing Huang ,&nbsp;Zhi-Yue Wang ,&nbsp;Quan Wang ,&nbsp;Can Zhao ,&nbsp;Xiang Lu ,&nbsp;Jin-Shui Xu ,&nbsp;Zheng-Kai Shen ,&nbsp;Wei Gao","doi":"10.1016/j.exger.2025.112865","DOIUrl":"10.1016/j.exger.2025.112865","url":null,"abstract":"<div><div>Sarcopenia is characterized by aging-related progressive loss of muscle mass and function; however, the specific and sensitive biomarkers are still limited. Biometals and trace elements provide a potential connection linking the environment and lifestyle to pathological processes of sarcopenia. The aim of the present study was to investigate the relationship between urinary trace elements levels and the presence of sarcopenia. A total of 100 older adults aged ≥65 years consisting of 50 patients with sarcopenia and 50 subjects without sarcopenia were enrolled. The urinary concentrations of 35 elements were examined by using inductively coupled plasma mass spectrometry. We found that a panel of 11 urinary elements including Ti, B, Na, Al, K, Ca, V, Rb, Sr, Cs, and Tl were decreased in patients with sarcopenia. Partial correlation analysis showed that urinary levels of Na (<em>r</em> = 0.242, <em>P</em> = 0.017) and Al (<em>r</em> = 0.303, <em>P</em> = 0.002) were positively correlated with gait speed. Multivariate logistic regression analysis showed that urinary Al level (adjusted OR = 0.986, 95 %CI =0.978–0.996, <em>P</em> = 0.004) was negatively associated with the risk of sarcopenia in older adults even after adjustment for potential confounding factors. ROC curve analysis indicated that the optimal cut-off value of urinary Al level for the prediction of sarcopenia was 46.53 μg/mL with a sensitivity of 58 % and a specificity of 78 % (AUC =0.691, 95 % CI =0.587–0.796, <em>P</em> &lt; 0.001). Taken together, our data indicate that urinary Al level shows potential as a biomarker associated with sarcopenia status in older adults. Further studies are needed to confirm the results of our study and elucidate the underlying mechanism by which Al participates in the pathogenesis of sarcopenia.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112865"},"PeriodicalIF":4.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE)","authors":"Zhi Meng Lim ,&nbsp;Yi Ern Chew ,&nbsp;Lihuan Guan ,&nbsp;Weilan Wang ,&nbsp;Muhammad Daniel A. Mahadzir ,&nbsp;Rajkumar Dorajoo ,&nbsp;Brian Kennedy ,&nbsp;Elena Sandalova ,&nbsp;Andrea B. Maier","doi":"10.1016/j.exger.2025.112867","DOIUrl":"10.1016/j.exger.2025.112867","url":null,"abstract":"<div><h3>Background</h3><div>Gerotherapeutic interventions that optimize the health and healthspan of biologically older, yet generally healthy adults are importance for reducing healthcare costs associated with ageing populations. It remains unclear whether recruiting middle-aged individuals with an older biological age is feasible in gerotherapeutic trials. The aim is to evaluate feasibility of recruiting biologically older yet generally healthy middle-aged adults for Alpha-ketoglutarate Supplementation and BiologicaL agE in middle-aged adults (ABLE) trial.</div></div><div><h3>Methods</h3><div>ABLE is a double-blind, placebo-controlled randomized trial assessing the effects of 1 g sustained-release calcium alpha-ketoglutarate versus placebo over 6 months, followed by 3 months of follow up visit, in 120 generally healthy adults (with at most one chronic condition) aged 40–60 years with a higher biological age (assessed by DNA methylation clocks) than chronological age living in Singapore. Feasibility analyses were done using the recruitment metrics; recruitment rate, consent rate, eligibility rate, recruitment conversion rate, and the effectiveness of recruitment strategies.</div></div><div><h3>Results</h3><div>Among 467 individuals who expressed interest in participation, 120 participants were enrolled in the study. The recruitment period was 223 working days. Eligibility rates were 80.3 % at pre-screening and 67.3 % at screening, with a consent rate of 66.1 %. Conversion rates were 25.7 % and 48.4 % from pre-screening and screening to enrolment, respectively. The biological age was exceeding the chronological age in 80.2 % of participants and 54.3 % reported no pre-existing health conditions. Word-of-mouth was the most effective recruitment method (36.2 %).</div></div><div><h3>Conclusion</h3><div>ABLE demonstrated the feasibility of recruiting biologically older yet generally healthy middle-aged adults for gerotherapeutic interventions.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112867"},"PeriodicalIF":4.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex- and age-related declines in muscle mass, strength, physical performance, and muscle quality among community-dwelling older adults: A cross-sectional study","authors":"Yujiro Asano ,&nbsp;Tsukasa Yoshida ,&nbsp;Kenji Tsunoda ,&nbsp;Keiichi Yokoyama ,&nbsp;Yuya Watanabe ,&nbsp;Yasuko Yoshinaka ,&nbsp;Tomohiro Okura ,&nbsp;Misaka Kimura ,&nbsp;Yosuke Yamada","doi":"10.1016/j.exger.2025.112862","DOIUrl":"10.1016/j.exger.2025.112862","url":null,"abstract":"<div><div>Muscle volume, strength, physical performance, and quality (functional and morphological domains) decline with age; however, the specific patterns and differences among these variables in old age remain unclear. We quantitatively assessed sex- and age-related changes and differences among these variables in older adults. We hypothesized that the rates of age-related decline differ among the parameters. Specifically, muscle quality would decline more steeply than muscle mass, with sex-related variations.</div><div>A cross-sectional survey of 1370 community-dwelling Japanese older adults (aged 65–90 years) was conducted. Muscle mass and volume were measured by appendicular lean mass (ALM) index using bioelectrical impedance spectroscopy (BIS) and thigh muscle thickness (MT) using ultrasonography. Physical performance was assessed by the 5-times chair stand, timed up-and-go test, maximum walking speed, and vertical jump × body weight. Handgrip strength (HG) and knee extension strength (KES) were used to assess muscle strength. Functional (HG/ALM and KES/MT) and morphological (whole-body and thigh phase angles [PhA], extracellular/intracellular water ratio [ECW/ICW] by BIS, and thigh echo intensity by ultrasonography) domain muscle qualities were assessed.</div><div>Linear regression predicted significant age-related declines in all parameters. The predicted decline rates/year were as follows: thigh MT (male: 0.9 %; female: 1.1 %), KES (male: 2.0 %; female: 2.1 %), lower extremity physical performance (male: 1.4–2.8 %; female: 1.8–3.0 %), thigh morphological muscle quality via BIS (male: 1.5–2.2 %; female: 1.4–1.9 %), echo intensity (male: 1.2 %; female: 0.5 %), and functional muscle quality (KES/MT) (male: 1.3 %; female: 1.3 %). The slopes of lower extremity strength, performance, and muscle quality were steeper than those of muscle mass. These patterns also varied by parameter and sex.</div><div>This study provides novel insight into the differential aging patterns of muscle mass, strength, performance, and functional (e.g., KES/MT) and morphological (e.g., PhA, ECW/ICW, EI) muscle quality by simultaneously comparing age- and sex-related changes in these parameters. Our findings highlight muscle quality, particularly in the lower limbs, as a sensitive and distinct indicator of age-related physical decline. These findings offer new perspectives for assessing and intervening with older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112862"},"PeriodicalIF":4.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multimorbidity and cognitive frailty among the elderly in China: the mediating effect of depressive symptoms","authors":"Jing Lv ,&nbsp;Fengmei Huang ,&nbsp;Yumei Shi","doi":"10.1016/j.exger.2025.112864","DOIUrl":"10.1016/j.exger.2025.112864","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship among multimorbidity, depressive symptoms, and cognitive frailty (CF) in the elderly, and to explore the mediating effect of depressive symptoms between multimorbidity and CF in the elderly.</div></div><div><h3>Methods</h3><div>The data for this study were derived from the 2018 China Health and Retirement Longitudinal Study (CHARLS). A sample of the elderly (aged ≥60 years) was selected. The associations of CF with multimorbidity and depressive symptoms were analyzed by logistic regression while adjusting for potential confounding factors. The mediating effect of depressive symptoms between multimorbidity and CF was verified using a <em>Z</em>-test.</div></div><div><h3>Results</h3><div>Among the 9217 participants, there were 6045 older adults with multimorbidity (65.6 %), 3566 with depressive symptoms (38.7 %), and 1591 with CF (17.3 %). Regression analysis showed that both multimorbidity (<em>OR</em> = 2.624, <em>P</em> &lt; 0.001) and depressive symptoms (<em>OR</em> = 2.737, <em>P</em> &lt; 0.001) increased the risk of CF in the elderly. The results of mediation analysis showed that multimorbidity was strongly associated with CF (<em>C</em> = 0.119, <em>P</em> &lt; 0.001). After incorporating depressive symptoms as a mediator into the model of multimorbidity and CF, the relationship between multimorbidity and CF remained significant (<em>C</em> = 0.098, <em>P</em> &lt; 0.001). <em>Z</em>-test results confirmed that the mediating role of depressive symptoms between multimorbidity and CF in the elderly was significant (<em>Z</em> = 2.96, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The status of CF in the elderly shouldn't be ignored. Multimorbidity and depressive symptoms are significantly related to CF, which increases the risk of CF in the elderly, and the mediating effect of depressive symptoms is significant in the relationship between multimorbidity and CF in the elderly.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"210 ","pages":"Article 112864"},"PeriodicalIF":4.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in social isolation and risk of frailty among older adults: results from two prospective cohorts","authors":"Fan Zhang ,&nbsp;Chang Liu ,&nbsp;Yan Bai ,&nbsp;Min Cao","doi":"10.1016/j.exger.2025.112863","DOIUrl":"10.1016/j.exger.2025.112863","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the longitudinal association between changes in social isolation and incident frailty in older adults.</div></div><div><h3>Methods</h3><div>Older adults from the China Health and Retirement Longitudinal Study (CHARLS) and the Survey of Health, Ageing, and Retirement in Europe (SHARE). About 3931 participants from CHARLS and 15,817 participants from SHARE aged 60 years and older who were non-frail at baseline were included. Social isolation was assessed using six questions in CHARLS (score ≥ 3) and four questions in SHARE (score ≥ 2). Frailty was defined as Rockwood Frailty Index ≥25. Changes in social isolation were categorized as “no isolation,” “developed isolation,” “resolved isolation,” and “persistent isolation”.</div></div><div><h3>Results</h3><div>In CHARLS, persistent isolation was associated with an increased risk of frailty (hazard ratio [HR], 1.2; 95 % confidence interval [95 % CI], 1.1–1.4), while neither developed isolation (HR, 1.1; 95 % CI, 1.0–1.3) nor resolved isolation (HR, 1.1; 95 % CI, 0.9–1.2) showed significant associations. In SHARE, both persistent isolation (HR, 1.4; 95 % CI, 1.2–1.6) and resolved isolation (HR, 1.3; 95 % CI, 1.0–1.6) were significantly associated with frailty, whereas developed isolation showed no significant association (HR, 1.1; 95 % CI, 1.0–1.2).</div></div><div><h3>Conclusions</h3><div>Changes in social isolation are significantly associated with the incidence of frailty in older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"209 ","pages":"Article 112863"},"PeriodicalIF":4.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}