Experimental gerontology最新文献

{"title":"Long-term prognostic value of CRP–albumin–lymphocyte index in elderly patients with heart failure with preserved ejection fraction","authors":"Qingwei He ,&nbsp;Yukun Cao ,&nbsp;Xingman Fan ,&nbsp;Bowen Li ,&nbsp;Qiongyi He ,&nbsp;Haitao Zhang","doi":"10.1016/j.exger.2025.112744","DOIUrl":"10.1016/j.exger.2025.112744","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure with preserved ejection fraction (HFpEF) is a complex and heterogeneous clinical condition characterized by the interplay of malnutrition and immune inflammation, especially in elderly patients. The CRP-Albumin-Lymphocyte (CALLY) index, a novel composite indicator reflecting immune inflammation and nutritional status, has not yet been validated as a prognostic tool in elderly patients with HFpEF.</div></div><div><h3>Methods</h3><div>This retrospective study included 320 elderly patients hospitalized at the Air Force Medical Center from October 2016 to April 2019 due to HFpEF. Patients were stratified into the all-cause mortality and the survival groups according to follow-up outcomes. Kaplan–Meier analysis and Cox regression were performed to identify risk factors associated with poor prognosis. Additionally, we constructed and evaluated a nomogram based on the CALLY index to predict survival rates.</div></div><div><h3>Results</h3><div>During the follow-up period, 137 cases (42.81 %) of patients experienced all-cause mortality. Kaplan-Meier survival curves and Cox regression analysis revealed that a lower CALLY index (HR 0.811, 95 % CI 0.714–0.921, <em>P</em> = 0.001) was independently associated with adverse prognosis in elderly patients with HFpEF. The nomogram incorporating the CALLY index exhibited robust predictive performance for predicting 1-year, 3-year, and 5-year survival outcomes.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that the CALLY index is an independent predictor of long-term mortality in elderly patients with HFpEF. The developed nomogram incorporating the CALLY index could effectively predict survival probabilities.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112744"},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA and piRNA differential expression profiles in Alzheimer's disease: A potential source of pathology and tool for diagnosis","authors":"Benjamin Landon ,&nbsp;Kumudu Subasinghe ,&nbsp;Nathalie Sumien ,&nbsp;Nicole Phillips","doi":"10.1016/j.exger.2025.112745","DOIUrl":"10.1016/j.exger.2025.112745","url":null,"abstract":"<div><div>Alzheimer's Disease (AD) is the most prevalent form of dementia and one of the leading causes of death in the United States, and despite our best efforts and recent advancements, a treatment that stops or substantially slows its progression has remained elusive. Small extracellular vesicles (sEVs), hold the potential to alleviate some of the common issues in the field by serving to better differentiate AD and non-AD individuals. These vesicles could provide insights into therapeutic targets, and potentially an avenue towards early detection. We compared the sEV cargo profiles of AD and non-AD brains (<em>n</em> = 6) and identified significant differences in both the micro RNA (miRNA) and Piwi-interacting RNA (piRNA) cargo through sEV isolation from temporal cortex tissue, followed by small RNA sequencing, and differential expression analysis. Differentially expressed miRNAs targeting systems relevant to AD included miR-206, miR-4516, miR-219a-5p, and miR-486-5p. Significant piRNAs included piR-6,565,525, piR-2,947,194, piR-7,181,973, and piR-7,326,987. These targets warrant further study for their potential role in the progression of AD pathology by dysregulating cellular activity; additionally, future large-scale studies of neuronal sEV miRNA profiles may facilitate the development of diagnostic tools which can aid in clinical trial design and recruitment. Longitudinal analysis of sEV data, perhaps accessible through plasma surveyance, will help determine at what point these miRNA and/or piRNA profiles begin to diverge between AD and non-AD individuals.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112745"},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway","authors":"Yating Wu ,&nbsp;Fengrui Li ,&nbsp;Shibin Shu ,&nbsp;Zhenhua Feng ,&nbsp;Yong Qiu ,&nbsp;Sen Li ,&nbsp;Zezhang Zhu","doi":"10.1016/j.exger.2025.112743","DOIUrl":"10.1016/j.exger.2025.112743","url":null,"abstract":"<div><h3>Background</h3><div>Intervertebral disc degeneration (IVDD) represents a prevalent degenerative pathology of the spinal, primarily precipitated by inflammatory processes and the deterioration of extracellular matrix (ECM). Baicalin has an effective anti-inflammatory effect on degenerative diseases. In addition, the P38 mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in the pathogenesis of IVDD.</div></div><div><h3>Objective</h3><div>To investigate the therapeutic potential of baicalin in modulating pathological changes in IVDD.</div></div><div><h3>Methods</h3><div>To design an in vitro model of degeneration of nucleus pulposus cells (NPCs) stimulated by IL-1β and an in vivo mouse model of needling to assess the protective effect of baicalin against IVDD and its underlying mechanism.</div></div><div><h3>Results</h3><div>Baicalin down-regulated inflammatory factors (INOS, COX-2, IL-6) and catabolic factors (MMP-3, MMP-13, ADAMTS-5) while up-regulating anabolic factors (collagen II, SOX-9) by inhibiting the activation of the p38 MAPK signaling pathway, in addition to slowing down the progression of IVDD in the mouse acupuncture model.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated in vitro experiments that baicalin attenuates IL-1β-stimulated IVDD by inhibiting activation of the P38 MAPK signaling pathway. Meanwhile, the effects of baicalin were also confirmed in vivo experiments, Consequently, we propose that baicalin is a promising therapeutic agent for the treatment of disc degeneration.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112743"},"PeriodicalIF":3.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of blood ethylene oxide levels with osteoarthritis and rheumatoid arthritis: Evidence from NHANES (2013–2020)","authors":"Zhaoyi Fang ,&nbsp;Qingxiang Hu ,&nbsp;Wenxin Liu","doi":"10.1016/j.exger.2025.112739","DOIUrl":"10.1016/j.exger.2025.112739","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoarthritis (OA) and rheumatoid arthritis (RA) are common conditions with important public health implications. The role of environmental toxins in their pathogenesis is increasingly recognized; however, the impact of ethylene oxide (EO) exposure on OA and RA remains unexplored. This study investigated the association between blood EO levels and the prevalence of OA and RA in the US population, using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2020.</div></div><div><h3>Methods</h3><div>NHANES 2013–2020 participants ≥40 years old with OA or RA who reported the condition during the NHANES interview were included. Blood EO levels were directly measured using hemoglobin adduct quantification. Univariate and multivariable logistic regression models were used to evaluate the association between EO exposure and OA and RA, adjusting for potential confounders. Restricted cubic spline (RCS) analysis was performed to assess potential non-linear relations.</div></div><div><h3>Results</h3><div>A total of 3476 participants (mean age: 60.0 years; 52.0 % female) were included in the study. In the unadjusted model, participants in the highest EO quintile did not have a significantly higher likelihood of OA (odds ratio [OR] = 1.23; 95 % confidence interval [CI]: 0.86–1.74) or RA (OR = 1.58; 95 % CI: 0.97–2.58) compared to those in the lowest quintile. However, after adjustment, participants in the highest EO quintile had significantly greater likelihood of having OA (aOR = 2.00; 95 % CI: 1.30–3.07) and RA (aOR = 1.81; 95 % CI: 1.08–3.03) compared to those in the lowest quintile. RCS analyses suggested no significant non-linear associations between EO exposure and OA or RA.</div></div><div><h3>Conclusion</h3><div>This study identified independent associations between EO exposures and an increased prevalence of OA and RA. These findings highlight the need for regulatory measures to minimize EO exposure and further investigations to confirm causal relationships.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112739"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition” [Exp. Gerontol. Volume 89 (2017), 45–56]","authors":"Jingxing Zhang ,&nbsp;Qiong Cai ,&nbsp;Ming Jiang ,&nbsp;Yigang Liu ,&nbsp;Hua Gu ,&nbsp;Jia Guo ,&nbsp;Hui Sun ,&nbsp;Jianmin Fang ,&nbsp;Lingjing Jin","doi":"10.1016/j.exger.2025.112733","DOIUrl":"10.1016/j.exger.2025.112733","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112733"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism of melatonin-mediated mitophagy regulating proline production to ameliorate skin aging","authors":"Tao Quan,&nbsp;Ran Li,&nbsp;Ting Gao","doi":"10.1016/j.exger.2025.112738","DOIUrl":"10.1016/j.exger.2025.112738","url":null,"abstract":"<div><div>Collagen loss is one of the major contributor to signs of skin aging such as dryness, roughness, and wrinkle formation, which is closely linked to a decline in the amount of proline produced in mitochondria. Melatonin has been shown to improve several clinical signs of skin aging, while the mechanism is unclear. In our study, we found that mitophagy, proline synthesis key enzyme NADK2 and proline and collagen levels were significantly reduced, while oxidative stress levels increased in aging skin, and melatonin supplementation could effectively up-regulate mitophagy level and restore proline synthesis and further improved skin aging. However, proline supplementation could also exert an anti-aging effect, while it had no effect on the mitochondrial dysfunction. Moreover, our study indicated that melatonin enters the cell by binding to the MT1 receptor and then enters the mitochondria via the PEPT1 transporter to exert its mitochondrial protective effects. This study helps to elucidate the mechanism of mitochondrial dysfunction-induced skin aging, and provides new theoretical guidance for revealing the mechanism of skin aging and rationally utilizing endocrine hormones to improve skin aging, which has a broad application prospect.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112738"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community","authors":"Minjun Kim ,&nbsp;Inhwan Lee","doi":"10.1016/j.exger.2025.112737","DOIUrl":"10.1016/j.exger.2025.112737","url":null,"abstract":"<div><h3>Purpose</h3><div>To examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 community-dwelling older women and assess physical activity’s mediating role.</div></div><div><h3>Methods</h3><div>Body composition was assessed using dual-energy X-ray absorptiometry, and the android-to-gynoid (A/G) fat ratio was calculated as the android fat proportion divided by the gynoid fat proportion. Participants were categorized into high and low 50 % groups based on the A/G fat ratio. Dysmobility syndrome was defined as the presence of at least three of the following: increased body fat percentage, decreased muscle mass, osteoporosis, slow gait speed, reduced grip strength, or a history of falls. Cognitive impairment was defined as a Mini-Mental State Examination for Dementia Screening score ≤ 23. Physical activity was measured using the International Physical Activity Questionnaire, with ≥600 metabolic equivalent of task-minutes per week classified as active and &lt; 600 as inactive. Binary logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the A/G fat ratio and physical activity. The mediating effects of physical activity were analyzed using Process Macro Model 4.</div></div><div><h3>Results</h3><div>Participants in the low 50 % A/G fat ratio group had higher odds of dysmobility syndrome (crude OR = 3.500, <em>p</em> &lt; 0.001; adjusted OR = 3.678, <em>p</em> = 0.002) and cognitive impairment (crude OR = 2.714, <em>p</em> = 0.005; adjusted OR = 3.293, p = 0.005) than did those in the high 50 % group, even after covariate adjustments. The inactive group had higher odds of dysmobility syndrome (crude OR = 4.185, <em>p</em> &lt; 0.001; adjusted OR = 3.199, <em>p</em> = 0.005) and cognitive impairment (crude OR = 3.190, <em>p</em> = 0.001; adjusted OR = 2.551, <em>p</em> = 0.022) than did the active group. Mediation analysis indicated that physical activity partially mediated the association between the A/G fat ratio and dysmobility syndrome (indirect effect = −0.5099, 95 % CI = −0.9045 to −0.1786) and cognitive impairment (indirect effect = 0.1446, 95 % CI = 0.0554 to 0.2582).</div></div><div><h3>Conclusion</h3><div>A lower A/G fat ratio increases the risks of dysmobility syndrome and cognitive impairment in older women; physical activity may mitigate these effects.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112737"},"PeriodicalIF":3.9,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques","authors":"Ludwig A.P. Metzler ,&nbsp;Jeanette M. Metzger ,&nbsp;Keenan J. Gerred ,&nbsp;Marina E. Emborg ,&nbsp;Amita Kapoor","doi":"10.1016/j.exger.2025.112736","DOIUrl":"10.1016/j.exger.2025.112736","url":null,"abstract":"<div><div>As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related neurodegenerative disorders are increasingly important for identifying early diagnostic biomarkers, monitoring disease progression, and evaluating treatment responsiveness. Rhesus macaques are an ideal species for studies on neurodegeneration due to their phylogenetic relatedness to humans and their complex brain anatomy and physiology. Technological advances in assay sensitivity have facilitated the identification of blood-based biomarkers of neurodegeneration and inflammation in human populations. The aim of this study was to translate these methods for use in male and female rhesus macaques across adulthood. We collected plasma samples from 47 rhesus macaques representing pre-adult (1–5 years, <em>n</em> = 6 female, <em>n</em> = 5 male), young (5–7 years, n = 5 female, <em>n</em> = 7 male), middle (8–16 years, n = 7 female, n = 7 male), and older adult (17–22 years, n = 6 female, <em>n</em> = 4 male) subjects. Quantified biomarkers included neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid beta (Aβ42, Aβ40, and their ratio), total tau, phosphorylated tau (pTau181), interleukin (IL) 2, IL-6, IL-8, and IL-10. Plasma NfL and IL-6 levels were significantly increased with age in both sexes, with a marked rise during middle adulthood. The ratio of Aβ42/Aβ40 was significantly lower in the middle and older aged females compared to the youngest group. There was no effect of age or sex on total tau or pTau181 levels. Overall, these results demonstrate the feasibility of evaluating blood biomarkers of neurodegeneration and inflammation in rhesus macaques during adulthood.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112736"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related peculiarities of antibody-mediated humoral immune response following SARS-CoV-2 infection","authors":"M. Movsisyan ,&nbsp;H. Harutyunyan ,&nbsp;Kh. Movsisyan ,&nbsp;I. Kasparova ,&nbsp;A. Hakobyan ,&nbsp;K. Yenkoyan","doi":"10.1016/j.exger.2025.112735","DOIUrl":"10.1016/j.exger.2025.112735","url":null,"abstract":"<div><div>Thousands of articles were published about the COVID-19 disease and hundreds about the immune response. But still little is known about the features of SARS-CoV-2-specific immunity in elderly. The aim of current research was to evaluate the age-related peculiarities of antibody mediated humoral immune response following SARS-CoV-2 infection. Our study presents an intriguing divergence from the classical concept of immunosenescence, where aging has been assumed to cause poor antibody responses, reduced or inefficient vaccination, and overall blunted immune responses in elderly people. Our findings were opposite to some of these expectations; participants aged over 60 expressed elevated titers of anti-SARS-CoV-2 antibodies in comparison to younger adults. Analyzing the data of relative neutralization and avidity of anti-SARS-Cov-2 (S) antibodies we propose that although older adults produce a higher quantity of antibodies, their functional efficiency appears relatively reduced exhibiting lower neutralizing capacity and binding strength per antibody compared to younger adults. We can assume that the immune system of the elderly may require a higher level of antibody production to obtain a comparable level of protection. Our findings highlight the intricate nature of immune responses in convalescent older adults. This has particular relevance to understanding immunity and vaccine responses in different age groups.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112735"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age related gut microbiota regulates energy-related metabolism to influence natural aging phenotypes in the heart","authors":"Shufen Wu ,&nbsp;Lingran Qiao ,&nbsp;Haiyan Liu ,&nbsp;Yan-Li Li ,&nbsp;Rui Wang ,&nbsp;Yiru Yin ,&nbsp;Enhui Li ,&nbsp;Lele Wang ,&nbsp;Xiaoya Guan ,&nbsp;Litian Yin ,&nbsp;Qinghua Liu ,&nbsp;Xiaoyang Peng ,&nbsp;Yutong Zhang ,&nbsp;Zhuanfang Yang ,&nbsp;Lin Zuo ,&nbsp;Ce Zhang","doi":"10.1016/j.exger.2025.112734","DOIUrl":"10.1016/j.exger.2025.112734","url":null,"abstract":"<div><div>As the population ages, problems pertaining to health and life expectancy due to the aging heart have become increasingly prominent. The gut microbiota has become a potential therapeutic target in several diseases, including cardiovascular diseases. Current studies on the roles of the gut microbiota in the cardiovascular system have focused mainly on cardiovascular diseases; therefore, the effects of the gut microbiota on the natural aging of myocardial tissue remain unclear. The present study aimed to explore the roles and mechanisms of the gut microbiota and related metabolites in the natural aging of the heart. Animal models of fecal microbiota transplantation (FMT) were established in elderly and young rats. 16S rRNA sequencing revealed that the gut microbiota of the recipients shifted toward the profile of the donors, with concomitant cardiac structure and diastolic function changes detected via ultrasound and positron emission tomography–computed tomography (PET–CT). A group of significantly enriched myocardial metabolites detected by LC/MS were involved in the fatty acid β-oxidation process. Together with altered glucose uptake, as revealed by PET–CT, changes in ATP content and mitochondrial structure further verified a metabolic difference related to energy among rats transplanted with the gut microbiota from donors of different ages. This study demonstrated that gut microbes may participate in the physiological aging process of the rat heart by regulating oxidative stress and autophagy. The gut microbiota has been shown to be involved in the natural aging of the heart at multiple levels, from the organ level to the metabolically plastic myocardiocytes and associated molecules.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"203 ","pages":"Article 112734"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}