Experimental gerontology最新文献

{"title":"Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women","authors":"Stephen J. Carter ,&nbsp;Tyler H. Blechschmid ,&nbsp;Emily B. Long ,&nbsp;Tenzin Yangchen ,&nbsp;Marissa N. Baranauskas ,&nbsp;Chad C. Wiggins ,&nbsp;John S. Raglin ,&nbsp;Andrew R. Coggan","doi":"10.1016/j.exger.2025.112764","DOIUrl":"10.1016/j.exger.2025.112764","url":null,"abstract":"<div><div>Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m²; <em>n</em> = 14) or older (≥65 y; 81.8 ± 10.4 kg/m²; <em>n</em> = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O_2peak). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O₂). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O₂. However, older women had lower aerobic capacity (<em>p</em> = 0.002, <em>ES</em> = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (<em>p</em> = 0.042, <em>ES</em> = 0.41). Among all participants, and independent of V̇O_2peak, MRT correlated with average daily fatigue (<em>r</em> = 0.500, <em>p</em> = 0.015), fatigue interference (<em>r</em> = 0.421, <em>p</em> = 0.046), and POMS total mood disturbance (<em>r</em>_<em>s</em> = 0.437, <em>p</em> = 0.037). Regression modeling revealed MRT and walking net V̇O₂ jointly explained 55 % (<em>R</em> = 0.744, <em>p</em> &lt; 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O₂ may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112764"},"PeriodicalIF":3.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxidative stress in the association between metabolic score for insulin resistance and stroke: evidence from two large population-based studies","authors":"Yi Tan ,&nbsp;Xing Lin ,&nbsp;Liquan Xie","doi":"10.1016/j.exger.2025.112761","DOIUrl":"10.1016/j.exger.2025.112761","url":null,"abstract":"<div><h3>Objective</h3><div>This study endeavors to unveil the association between the Metabolic Score for Insulin Resistance (METS-IR) and stroke among adults utilizing data of the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS), and whether oxidative stress (OS) mediates their association.</div></div><div><h3>Methods</h3><div>Our study cohort comprised 101,316 individuals from NHANES and 17,708 individuals from CHARLS. The intricate relationships among the METS-IR, stroke, and OS biomarkers were evaluated via logistic regression, restricted cubic splines (RCS), as well as mediation analysis.</div></div><div><h3>Results</h3><div>The final analysis included 22,542 American and 9521 Chinese participants, among whom 844 and 887 were diagnosed with stroke, respectively. Regression analysis indicated a positive association of METS-IR with stroke [NHANES: <em>OR</em> = 1.01, <em>95 % CI</em> (1.01, 1.02), <em>p</em> &lt; 0.001; CHARLS: <em>OR</em> = 1.02, <em>95 % CI</em> (1.02, 1.03), <em>p</em> &lt; 0.001], with higher METS-IR quartiles being associated with elevated stroke incidence [NHANES: <em>OR</em> = 1.39, <em>95 % CI</em> (1.11, 1.73), <em>p</em> = 0.004; CHARLS: <em>OR</em> = 1.74, <em>95 % CI</em> (1.39, 2.17), <em>p</em> &lt; 0.001]. Participants with elevated METS-IR and serum uric acid (SUA) exhibited the greatest probability of stroke. Mediation analysis proved that OS partially mediated this association [Mediation effect: NHANES <em>β</em> = −8.45e−5, <em>95 % CI</em> (−1.41e−4, −4.01e−5), <em>p</em> &lt; 0.001; CHARLS <em>β</em> = −4.02e−5, <em>95 % CI</em> (−8.14e−5, −7.76e−6), <em>p</em> = 0.012].</div></div><div><h3>Conclusion</h3><div>The METS-IR was positively associated with stroke in NHANES and CHARLS cohorts, and OS partially mediated this association.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112761"},"PeriodicalIF":3.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel_circ_0004013 targeting miR-29a-3p affects age-related hearing loss in miR-29a mouse model by RNA-seq analysis","authors":"Mulan Li ,&nbsp;Bingqian Li ,&nbsp;Shuli Wang ,&nbsp;Pengcheng Liu ,&nbsp;Zhen Liu ,&nbsp;Tihua Zheng ,&nbsp;Ruishuang Geng ,&nbsp;Bo Li ,&nbsp;Qingyin Zheng ,&nbsp;Peng Ma","doi":"10.1016/j.exger.2025.112758","DOIUrl":"10.1016/j.exger.2025.112758","url":null,"abstract":"<div><div>Age-related hearing loss (ARHL) is a gradual, symmetrical sensorineural disorder. Exploring the pathogenesis of ARHL from a biological perspective is important for its treatment. In this study, we analyzed the circRNA expression profiles of 2-month-old <em>miR-29a</em>^+/+ mice and <em>miR-29a</em>^−/− mice by transcriptome sequencing to investigate the role of circRNAs in ARHL. We identified 12 differentially expressed circRNAs in the two groups. Our focus was on circRNAs predicted to regulate <em>miR-29a</em>, with novel_circ_0004013 identified as having a targeted binding relationship with miR-29a-3p. Dual luciferase assays confirmed that miR-29a-3p is a direct target of novel_circ_0004013. Fluorescence in situ hybridization (FISH) was employed to localize the novel_circ_0004013 in HEI-OC1 cells and the cochlea. Novel_circ_0004013 was mainly expressed in the cytoplasm. In the hair cells (HCs) and stria vascularis (SV) regions of <em>miR-29a</em>^−/− mice, novel_circ_0004013 expression was higher than the corresponding regions in <em>miR-29a</em>^+/+ mice. Furthermore, Western blot assays revealed that levels of oxidative stress and apoptosis were significantly decreased in HEI-OC1 cells following the knockdown of novel_circ_0004013, whereas these levels were significantly increased in HEI-OC1 cells after the knockdown of miR-29a-3p. It was indicated in rescue assays that novel_circ_0004013 expedited oxidative stress and apoptosis of HEI-OC1 cells via modulation on miR-29a-3p. These findings may reveal the important role of novel_circ_0004013 in hearing loss and provide a new perspective and theoretical basis for the molecular mechanism of ARHL.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112758"},"PeriodicalIF":3.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A societal cost-benefit analysis of falls prevention in community-dwelling older people in the Netherlands","authors":"Martien J.M. Panneman ,&nbsp;Ed F. van Beeck ,&nbsp;Branko F. Olij ,&nbsp;Juanita A. Haagsma ,&nbsp;Frans van Zoest ,&nbsp;Judith I. Kuiper ,&nbsp;Suzanne Polinder","doi":"10.1016/j.exger.2025.112755","DOIUrl":"10.1016/j.exger.2025.112755","url":null,"abstract":"<div><h3>Background</h3><div>Aging populations face rising incidents of falls among older people, leading to increased healthcare costs. Preventive measures can reduce this burden and associated costs. However, implementing falls prevention interventions causes costs for society. In order to gain insight in the balance between investments and gains for society the Societal Cost Benefit Analysis (SCBA) methodology can be applied. We conducted a societal cost-benefit analysis (SCBA) of falls prevention interventions in the Netherlands in order to show the stepwise approach, data sources needed and analyses that characterize this method.</div></div><div><h3>Methods</h3><div>We used SCBA to assess falls prevention interventions' costs and benefits for three stakeholders: private health insurance companies, the national government, and local government. We created five healthcare scenarios for falls prevention interventions, involving informal care, primary care, home care, social work, and an integral scenario. Our SCBA model considered all associated costs with case-finding, screening, and recruitment for each scenario, as well as multifactorial falls prevention programs' costs and benefits, such as reduced healthcare expenses and health gains (DALYs).</div></div><div><h3>Results</h3><div>All scenarios lead to health gains, ranging from 90 averted DALYs in the informal care to 300 in the primary care scenario.The net benefits per 100,000 senior citizens of falls prevention programs range from €0.2- €5.6 million respectively for social care and home care scenario with benefit-cost ratios of respectively 1.1 and 2.5. Sensitivity analysis revealed that a lower age limit accompanied by a low initial fall risk for recruitment significantly influence the SCBA outcomes.</div></div><div><h3>Conclusion</h3><div>Structural implementation of evidence-based falls prevention can provide significant health benefits and net cost savings, supporting its implementation at the societal level. The SCBA offers guidance to policymakers on the optimal falls prevention programs for older people, reducing the disease burden of falls in the Netherlands.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112755"},"PeriodicalIF":3.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients","authors":"Min Chen ,&nbsp;Gongbing Guo ,&nbsp;Shuangyu Liu ,&nbsp;Jingjing Cai ,&nbsp;Xueying Tong ,&nbsp;Xia Liu ,&nbsp;Yufei Zhang ,&nbsp;Yanhong Chen ,&nbsp;Jiangtao Huo","doi":"10.1016/j.exger.2025.112762","DOIUrl":"10.1016/j.exger.2025.112762","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to explore the relationship between self-reported sleep disturbances (e.g., insomnia, REM sleep behavior disorder [RBD]) and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease (PD) patients.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study comparing 100 PD patients (observation group) with 100 age-matched controls. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and serum levels of amyloid-beta (Aβ1-42), α-synuclein, and inflammatory markers (CRP, TNF-α, IL-1β) were quantified.</div></div><div><h3>Results</h3><div>PD patients exhibited significantly poorer sleep quality (PSQI total score: 2.11 ± 0.27 vs. 0.52 ± 0.02, <em>P</em> &lt; 0.001), reduced parietal cortical thickness (2.68 ± 0.12 mm vs. 3.15 ± 0.18 mm, <em>P</em> = 0.003), and lower brainstem volume (2697.42 ± 147.05 mm³ vs. 3185.16 ± 255.41 mm³, <em>P</em> = 0.007) compared to controls. Biomarker profiling revealed elevated amyloid pathology in PD, with higher serum Aβ1-42 (median [IQR]: 1.98 [1.75–2.22] vs. 1.14 [1.10–1.19], <em>P</em> &lt; 0.001) and α-synuclein (2.03 [1.85–2.22] vs. 1.06 [1.03–1.10], <em>P</em> &lt; 0.001). Proinflammatory markers were markedly increased in PD, including CRP (9.30 [7.85–10.75] vs. 6.30 [5.60–7.10], <em>P</em> = 0.01), TNF-α (372.20 [329.85–414.55] vs. 184.50 [165.20–203.80], <em>P</em> &lt; 0.001), and IL-1β (573.50 [497.15–649.85] vs. 115.40 [101.05–129.75], <em>P</em> &lt; 0.001). Multivariate analysis identified cortical thinning, brainstem atrophy, and IL-1β elevation as independent predictors of sleep disturbances (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>These findings highlight the interplay between neuroanatomical changes, amyloid pathology, and systemic inflammation in PD-related sleep dysfunction, suggesting potential therapeutic targets.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112762"},"PeriodicalIF":3.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnesium depletion score in relation to frailty prevalence and mortality in US older adults: Evidence from 1999–2018 NHANES","authors":"Haifeng Jiang ,&nbsp;Wei Tao ,&nbsp;Ting Jia ,&nbsp;Weiwei Liu","doi":"10.1016/j.exger.2025.112757","DOIUrl":"10.1016/j.exger.2025.112757","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the associations between magnesium depletion score (MDS) and frailty prevalence, as well as its prognostic significance for all-cause and cardiovascular mortality among US older adults with frailty.</div></div><div><h3>Methods</h3><div>We analyzed data from older adults participating in the 1999–2018 National Health and Nutrition Examination Survey. The primary exposure was MDS, and the main outcomes were prevalence of frailty as defined by the 49-item accumulation-deficit model and all-cause or cardiovascular mortality in frail participants. The associations between MDS and frailty prevalence or mortality were analyzed using multivariable-adjusted logistic regression and Cox proportional hazards models, respectively.</div></div><div><h3>Results</h3><div>Overall, 13,551 participants (mean age 71.31 years, 45.46 % men, 4464 with frailty) were included. Compared with the MDS = 0 group, the multivariable-adjusted odds ratio and 95 % confidence interval (CI) for frailty were 1.144 (0.899–1.456), 1.702 (1.327–2.183), and 2.661 (2.038–3.475) for the MDS = 1, MDS = 2, and MDS ≥ 3 groups, respectively. A total of 2195 (791 cardiovascular-related) deaths occurred during a median follow-up of 70 months. Compared with the MDS = 0 group, the hazard ratios and 95 % CIs for the MDS = 1, MDS = 2, and MDS ≥ 3 groups were 1.509 (1.146–1.986), 1.988 (1.515–2.611), and 2.751 (2.125–3.562), respectively, for all-cause mortality, and 1.376 (0.843–2.246), 1.933 (1.183–3.160), and 2.872 (1.817–4.541), respectively for cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>A higher MDS is related to a higher prevalence of frailty and increased risk of all-cause and cardiovascular mortality in US older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112757"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equating conversion norms for the Mini-Mental State Examination and Montreal Cognitive Assessment in healthy subjects and patients with neurodegenerative disorders","authors":"Sara Bernini ,&nbsp;Elena Ballante ,&nbsp;Marta Picascia ,&nbsp;Marica Barbieri ,&nbsp;Alfredo Costa ,&nbsp;Elena Cavallini ,&nbsp;Cristina Tassorelli ,&nbsp;Tomaso Vecchi ,&nbsp;Sara Bottiroli","doi":"10.1016/j.exger.2025.112756","DOIUrl":"10.1016/j.exger.2025.112756","url":null,"abstract":"<div><h3>Introduction</h3><div>The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are globally recognized as validated cognitive screening tests widely used.</div></div><div><h3>Objective/aim</h3><div>The present study attempted to provide conversion tables from the MMSE to the MoCA and vice versa, deriving them from a large population of healthy older adults and a representative clinical sample of subjects with different types of cognitive decline within the spectrum of Alzheimer's (AD) and Parkinson's (PD) diseases.</div></div><div><h3>Methods</h3><div>A total of 1423 Italian participants, including healthy adults (n = 1203), individuals with AD (n = 93), and with PD (n = 127) were assessed using the MMSE and MoCA. Conversion tables were developed using log-linear smoothing equipercentile equating (LSEE). The reliability of the conversion was assessed through the Root Mean Square Error (RMSE) in a train-test approach confirmed in the whole sample.</div></div><div><h3>Results</h3><div>The findings demonstrated that the LSEE method enables the development of conversion tables allowing users to identify the corresponding MoCA score for each MMSE score within the studied groups, and vice versa. The estimation error RMSE was 1.8, 2.9, and 3.2 for the conversion of MoCA from MMSE and 1.2, 2.3, and 2.2 for the conversion of MMSE from MoCA in healthy subjects, AD, and PD, respectively. The reliability of the conversion is higher in healthy subjects and for higher values of MoCA and MMSE.</div></div><div><h3>Conclusion</h3><div>Results report easy-to-use conversion norms for transforming raw MMSE score to MoCA and vice versa, highlighting areas were the conversion has a strong or low reliability depending on the score range.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112756"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microRNAs in dexamethasone-induced skeletal muscle atrophy","authors":"Subi Ren ,&nbsp;Jie Chai ,&nbsp;Lijuan Zhang ,&nbsp;JiGang Li ,&nbsp;Xi Long ,&nbsp;Tinghuan Zhang","doi":"10.1016/j.exger.2025.112749","DOIUrl":"10.1016/j.exger.2025.112749","url":null,"abstract":"<div><div>Muscle atrophy is characterized by a decrease in muscle mass, strength, and activity. Recently, it was determined that microRNAs (miRNAs) can regulate muscle atrophy and that dexamethasone (Dex), an allergy and autoimmune disorder treatment that can induce muscle atrophy. Therefore, this study was designed to identify miRNAs expressed in Dex-induced muscle atrophy in mice using small RNA sequencing. A total of 820 miRNAs were identified, with 58 miRNAs expressed explicitly in atrophic muscles. Dex-induced muscle atrophy miRNAs clustered separately from the differential miRNAs in aging, disuse, and cancer-induced muscle atrophy models. The target genes of Dex-induced muscle atrophy miRNAs were independently enriched in inositol phosphate metabolism, hypoxia-inducible factor-1 signaling pathway, <em>etc.</em> Of note, there was a significant increase in the volume of fat cells and adipose weight in the Dex group, suggesting that fat deposition during Dex-induced skeletal muscle atrophy is a unique and typical feature.</div></div><div><h3>Simple summary</h3><div>Dexamethasone (Dex) is a glucocorticoid used to treat allergic and autoimmune diseases, but excessive use can lead to skeletal muscle atrophy. We used dexamethasone (Dex) to build a muscle atrophy model in mice, and obvious changes had taken place in mouse body weight, muscle tissue morphology and related genes. A large number of microRNAs were found to be differentially expressed, and their functions were enriched in pathways related to muscle development. At the same time, we compared the similarities and differences of microRNAs and their functions between Dex induced muscle atrophy model and other muscle atrophy models. Finally, we were surprised to find that Dex induced muscle atrophy is specifically accompanied by the accumulation of body fat.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112749"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study","authors":"Wan-Ju Liao ,&nbsp;Hsi-Yu Lai ,&nbsp;Liang-Yi Lin ,&nbsp;Cheng-Hsueh Wu ,&nbsp;Fei-Yuan Hsiao ,&nbsp;Liang-Kung Chen","doi":"10.1016/j.exger.2025.112754","DOIUrl":"10.1016/j.exger.2025.112754","url":null,"abstract":"<div><h3>Aims</h3><div>Frailty, a common and clinically significant condition in older adults with heart failure (HF), is often overlooked in emergency department (ED) settings. This study aims to evaluate the impact of frailty on clinical outcomes in older adults directly discharged from the ED due to HF.</div></div><div><h3>Methods and results</h3><div>This retrospective cohort study used data from Taiwan's National Health Insurance (NHI) database, identifying older adults (≥65 years) discharged from the ED due to HF between 2017 and 2021. Frailty was assessed using a 38-item multimorbidity frailty index (mFI) derived from ICD-10-CM codes, stratifying patients into fit, mild-to-moderately frail, and severely frail. Outcomes included all-cause mortality, all-cause readmissions, and HF-related readmissions. Cox regression and Fine and Gray models estimated the impact of frailty on these outcomes. Among 42,989 older HF patients (mean age 80.7 ± 8.2 years, 55.5 % female), 57.8 % were frail (46.4 % mild-to-moderately frail and 11.4 % severely frail). Six-month mortality rates were 12.0 % in fit, 16.0 % in mild-to-moderately frail, and 19.4 % in severely frail patients. Readmission rates showed similar patterns. The severely frail group had higher risks of mortality (aHR 1.44, 95 % CI 1.33–1.55), all-cause readmissions (sHR 1.69, 95 % CI 1.62–1.76), and HF-related readmissions (sHR 1.59, 95 % CI 1.48–1.71).</div></div><div><h3>Conclusion</h3><div>Frailty is prevalent among older adults directly discharged from the ED due to HF and significantly elevates risks of mortality and readmissions. These findings highlight the need for frailty assessment in ED settings for older HF patients to optimize care planning, and improve outcomes.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112754"},"PeriodicalIF":3.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia index based on serum creatinine and cystatin C is associated with all-cause mortality in patients aged 50 and over with hip fracture","authors":"Longqing Yu ,&nbsp;Fupeng Liu ,&nbsp;Qiuping Zhang ,&nbsp;Wenhua Yan ,&nbsp;Mei Zhang","doi":"10.1016/j.exger.2025.112750","DOIUrl":"10.1016/j.exger.2025.112750","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia index (SI), calculated as serum creatinine/cystatin C × 100, has emerged as a potential marker for muscle loss and adverse outcomes. However, its prognostic value in hip fracture patients remains unclear. This study aimed to investigate the association between SI and all-cause mortality in patients aged 50 and over with hip fracture.</div></div><div><h3>Methods</h3><div>This study included patients aged 50 and over with low-energy hip fractures and followed them for at least two years to track the incidence of death. Collect baseline demographic, clinical and biochemical data. Kaplan-Meier and log-rank analyses were performed to compare the mortality between different SI levels. Univariate and multivariate cox regression models were used to evaluate the relationship between SI and all-cause mortality in patients aged 50 and over with hip fracture. Subgroup analysis was carried out to evaluate the influence of potential regulators, and cubic spline curves were limited to check the potential nonlinear relationship between SI and all-cause mortality.</div></div><div><h3>Results</h3><div>A total of 637 patients were enrolled in the study, 62 deaths occurred during follow-up. Non-survivors were significantly older (80.02 ± 9.24 vs 71.05 ± 10.75 years, <em>P</em> &lt; 0.001) and had lower SI values (54.06 ± 11.17 vs 61.51 ± 14.51, P &lt; 0.001) compared to survivors. Kaplan-Meier analysis showed significantly better survival in the high SI group (<em>P</em> = 0.0034). In multivariate analysis, SI remained independently associated with mortality after adjusting for comprehensive covariates (HR = 0.98, 95 % CI: 0.95–0.99, <em>P</em> = 0.018). Restricted cubic spline analysis revealed a nearly linear relationship between SI and the risk of death in patients with hip fractures. In subgroup analysis except in diabetes and BMI ≥ 24, SI was negatively correlated with the second hip fracture.</div></div><div><h3>Conclusions</h3><div>Lower SI values are independently associated with increased all-cause mortality in patients aged 50 and over with hip fracture. SI might serve as a valuable prognostic marker for risk stratification in this population, potentially helping identify high-risk patients who may benefit from more intensive monitoring and intervention.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"204 ","pages":"Article 112750"},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}