Experimental gerontology最新文献

{"title":"Complex relationships among various domains of intrinsic capacity and their associated factors in community-dwelling older adults: A network analysis","authors":"Tianle Zou ,&nbsp;Jialin Liu ,&nbsp;Li Zhang ,&nbsp;Fang Liu ,&nbsp;Enming Zhang ,&nbsp;Xiaolong Wang ,&nbsp;Jun Ju ,&nbsp;Xiuxiu Huang ,&nbsp;Qiong Fang","doi":"10.1016/j.exger.2025.113020","DOIUrl":"10.1016/j.exger.2025.113020","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to adopt the network analysis approach to elucidate the complex associations among various domains of intrinsic capacity (IC) and the factors contributing to IC impairments among community-dwelling older adults based on the health ecological model.</div></div><div><h3>Methods</h3><div>A cross-sectional design was adopted, and older adults were recruited from local community health centers. IC was assessed using standardized tools recommended by the World Health Organization. The potential influencing factors of IC were collected based on the health ecological model, including personal characteristics, behavioral lifestyles, interpersonal networks, and living and working conditions. Network analyses were performed using a mixed graphical model to explore the complex relationships among IC domains and their associated factors.</div></div><div><h3>Results</h3><div>Among 3398 eligible participants, 2634 (77.52 %) individuals showed IC impairment, including mobility impairment (46.60 %), cognition impairment (39.38 %) and sensory impairment (35.00 %). Cognition and mobility functions were strongly interrelated (<em>r</em> = 0.24). The predictability values for IC domains were 27.7 % for cognition, 22.9 % for mobility, 15.4 % for psychology, 8.0 % for vitality and 7.5 % for sensory function. Education, age, monthly income, and the number of comorbidities showed close correlations with multiple IC domains. Furthermore, cognition showed specific positive links with lifestyles involving more mental engagement and intellectual work. Mobility was particularly associated with physical activity, including leisure time and household physical activities. Psychological capacity showed a specific association with sleep quality.</div></div><div><h3>Conclusions</h3><div>IC, particularly in the domains of cognition and mobility, was prevalently impaired among older adults. We identified both common and domain-specific factors associated with IC, offering insights for developing targeted interventions to enhance IC.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113020"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-Galactose induces the senescence and senescence-related secretory phenotype switch of nucleus pulposus cells","authors":"ShuWen Zhang ,&nbsp;Jing Du ,&nbsp;Dilimulati Aikeremu ,&nbsp;ZhanBin Ma ,&nbsp;Hao Wang","doi":"10.1016/j.exger.2026.113025","DOIUrl":"10.1016/j.exger.2026.113025","url":null,"abstract":"<div><div>Senescence of nucleus pulposus cells (NPCs) in degenerative intervertebral discs is related to the development and progression of intervertebral disc degeneration (IVDD). The aim of this study was to establish a reliable and robust cell senescent model using D-galactose (D-Gal) to induce oxidative stress in NPCs. NPCs were isolated from Sprague Dawley rats and incubated with increasing concentrations of D-Gal. Cell viability, cell cycle, senescence-associated markers, and extracellular matrix were detected to evaluate the effect of D-Gal on NPCs. The migration and polarization of macrophage were observed by Transwell assay and flow cytometry. Finally, the oxidative stress mechanism of D-Gal induced NPCs senescence was analyzed by flow cytometry and absorbance analysis. Cell viability and cell cycle analyses revealed that D-Gal induced senescence by blocking DNA synthesis and decreasing NPC proliferation. Furthermore, a dose-dependent increase was observed in senescence-associated makers in D-Gal induced NPCs. RT-qPCR analysis revealed an increase in mRNA expression of key senescence related secretory phenotype (SASP) components. Extracellular matrix was significantly decreased along with cell senescence. Transwell assay and flow cytometry revealed that senescent NPC-conditioned medium triggered macrophage migration and polarization. Increased levels of reactive oxygen species (ROS), advanced glycation end products, and the lipid peroxidation product malondialdehyde, along with decreased superoxide dismutase activity, were associated with the senescence of NPCs induced by D-Gal. The data imply that D-Gal treatment successfully triggered senescence in NPCs and SASP switch, establishing it as a reliable model for studying IVDD.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113025"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing predictive energy-expenditure equations with indirect calorimetry in older adults living in long-term care facilities","authors":"Katarzyna Zadka ,&nbsp;Krzysztof Ławiński ,&nbsp;Natalia Grodzicka ,&nbsp;Atanas G. Atanasov ,&nbsp;Michał Ławiński","doi":"10.1016/j.exger.2026.113037","DOIUrl":"10.1016/j.exger.2026.113037","url":null,"abstract":"<div><h3>Objective</h3><div>Accurate estimation of resting energy expenditure (REE) in long-term care facilities (LTCFs) is challenging, and indirect calorimetry (IC) is seldom available. This cross-sectional study assessed the agreement between predictive equations and IC in older adults residing in LTCFs.</div></div><div><h3>Research methods &amp; procedures</h3><div>REE was measured by IC and compared with estimates from 22 predictive equations. Agreement was evaluated using linear regression (R²), root mean square error (RMSE), Bland–Altman analysis, individual-level accuracy (90–110% of measured REE), mean percentage bias (%Bias), Lin's concordance correlation coefficient (CCC), and extreme prediction errors.</div></div><div><h3>Results</h3><div>A total of 182 residents were enrolled (72% women; mean age 81.24 ± 9.21 years; BMI 23.05 ± 5.11 kg/m²). Across equations, R² ranged from 0.24 to 0.41, RMSE from 230 to 317 kcal/d, and individual accuracy from 27% to 45%. Mean percentage bias ranged from –6% to +18%, indicating systematic under- and overestimation across models. The most consistent overall performance was observed for Lührmann, Müller, and Liu equations. Nonetheless, Bland–Altman analysis revealed wide limits of agreement, and CCC values indicating poor-to-moderate concordance (0.465–0.624). Several equations also produced extreme errors, demonstrating limited interchangeability with IC at the individual level.</div></div><div><h3>Conclusion(s)</h3><div>In people living in LTCFs, predictive equations showed modest explanatory power and low individual accuracy, with wide limits of agreement indicating that none can reliably replace IC when precise estimation of REE is required. Clinically, predicted REE should be regarded as an estimate rather than a dose, requiring cautious adjustment and verification against short-term monitoring of body weight, intake, and clinical status. When precise energy dosing is critical, IC should be used whenever feasible.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113037"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idebenone protects against doxorubicin-induced cardiac injury by inhibiting ferroptosis in cardiomyocytes","authors":"Jie Mao ,&nbsp;Zhiyi Zhou ,&nbsp;Yuting Xu ,&nbsp;Hangbo Qu ,&nbsp;Bo Ma ,&nbsp;Yihua Yu","doi":"10.1016/j.exger.2026.113039","DOIUrl":"10.1016/j.exger.2026.113039","url":null,"abstract":"<div><div>Heart failure (HF) remains a global health challenge with limited efficacious therapies, necessitating novel strategies targeting its underlying pathological mechanisms. Emerging evidence implicates dysregulated iron metabolism and ferroptosis-an iron-dependent form of regulated cell death-as critical drivers of cardiomyocyte attrition in heart failure pathogenesis. This study investigates the therapeutic potential of idebenone (IDE), a clinically approved mitochondrial-targeted antioxidant and short-chain analog of coenzyme Q10, in modulating ferroptosis-mediated cardiac dysfunction. We confirmed that idebenone significantly attenuated pathological markers of cardiac stress, reducing expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in cardiomyocytes. Furthermore, idebenone treatment suppressed lipid peroxidation and mitochondrial iron overload. In the HF animal model, idebenone administration improved left ventricular ejection fraction, restored redox homeostasis and reduced cardiac iron deposition. These findings establish idebenone as a promising strategy to mitigate ferroptosis-driven myocardial injury, providing a translational framework for developing idebenone-based therapies for heart failure management.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113039"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women: a non-randomized study","authors":"Mila Vukadinović Jurišić ,&nbsp;Roberto Roklicer ,&nbsp;Anja Obradović ,&nbsp;Sandra Stefan ,&nbsp;Antonino Bianco ,&nbsp;Patrik Drid ,&nbsp;Jelena Obradović","doi":"10.1016/j.exger.2025.113016","DOIUrl":"10.1016/j.exger.2025.113016","url":null,"abstract":"<div><h3>Objective</h3><div>The present study aimed to investigate the effects of specially designed training program based on multicomponent and stability exercises on body composition, physical fitness, and functional movement capability in active older women.</div></div><div><h3>Methods</h3><div>Thirty active older women (age 69.37 ± 3.66 years; body height 162.59 ± 6.14 cm; body mass 71.25 ± 8.08 kg) were divided into an intervention group (IG, <em>n</em> = 15) and a control group (CG, n = 15). The IG performed 14 weeks of a specially designed training program. Body composition parameters (muscle mass, fat mass, body mass, basal metabolic rate, and visceral fat mass) were assessed using Bioelectrical Impedance Analysis. Physical fitness was measured with Single-Leg Stance (SLS), 8-ft-up-and-go test (8UG), 30-s chair stand test (30-s CST), and Handgrip strength test left/right hand (HGS L/R). The functional movement capability was measured with a Functional Movement Screen (FMS).</div></div><div><h3>Results</h3><div>After 14 weeks IG significantly improved (<em>p</em> &lt; 0.001) parameters of body composition (muscle mass, fat mass, body mass, body mass index) and physical fitness (8UG, 30-s CST, SLS, HST-R) compared to CG. The improvements in all FMS tests (Deep Squat, Hurdle Step, In-Lune Lunge, Shoulder mobility, Active Straight Leg Raise, Trunk Stability Push-Up, and Rotary Stability) were greater in the IG compared to the CG (p &lt; 0.001). In addition, IG showed higher Total FMS score compared to CG (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The combination of multicomponent and stability exercises as a novel approach is a convincing strategy that can improve body composition, physical fitness, and functional movement capability among active older women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113016"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher openness and conscientiousness are associated with lower risk of long-term care needs: A 22-year follow-up of community-dwelling older adults in Japan","authors":"Yukiko Nishita ,&nbsp;Chikako Tange ,&nbsp;Sayaka Kubota ,&nbsp;Shu Zhang ,&nbsp;Mana Tateishi ,&nbsp;Fujiko Ando ,&nbsp;Hiroshi Shimokata ,&nbsp;Rei Otsuka","doi":"10.1016/j.exger.2026.113040","DOIUrl":"10.1016/j.exger.2026.113040","url":null,"abstract":"<div><h3>Background</h3><div>Personality traits have been associated with physical and mental health outcomes, yet their relationship with long-term care (LTC) needs remains understudied.</div></div><div><h3>Objective</h3><div>To examine the longitudinal effect of personality traits on the incidence of LTC needs among community-dwelling older adults in Japan.</div></div><div><h3>Methods</h3><div>Data were drawn from the National Institute for Longevity Sciences–Longitudinal Study of Aging (NILS-LSA), involving 1003 older adults (≥65 years; mean age 73.0 ± 4.4; 48.6% male), who had no certification of LTC needs prior to baseline or within two years after baseline to prevent reverse causality. Personality traits were assessed at baseline using the Japanese version of the NEO Five-Factor Inventory. Participants were followed for up to 21.8 years (mean ± SD: 12.2 ± 5.7 years) to determine the incidences of long-term care (LTC) needs by the LTC Insurance System certificate. Cox proportional hazards models were used to estimate hazard ratios for the incidence of long-term care (LTC) needs per one standard deviation (1-SD) increase in each personality trait score, adjusting for relevant covariates.</div></div><div><h3>Results</h3><div>During follow-up, 583 individuals (58.1%) were newly certified for LTC needs. Higher levels of openness and conscientiousness were associated with reduced LTC needs incidence (HR [95% CI] 0.88 [0.81–0.95], <em>p</em> = 0.002; 0.91 [0.84–0.99], <em>p</em> = 0.030, respectively). No significant associations were found for neuroticism, extraversion, or agreeableness.</div></div><div><h3>Conclusion</h3><div>Among older adults living in the community, higher openness and conscientiousness were protective against future LTC needs. These findings highlight the potential role of psychological traits in promoting autonomy and healthy aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113040"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways","authors":"Junwan Fan ,&nbsp;Ling Zhou ,&nbsp;Run Song ,&nbsp;Fuqiang Yang ,&nbsp;Yingjie Geng ,&nbsp;Xueyu Zhang ,&nbsp;Qiuhua Yu ,&nbsp;Zirui Li ,&nbsp;Yan Wang ,&nbsp;Wenyan He","doi":"10.1016/j.exger.2026.113027","DOIUrl":"10.1016/j.exger.2026.113027","url":null,"abstract":"<div><div>The mass of inguinal white adipose tissue (iWAT) decreases with age, and its dysfunction contributes to systemic effects, including chronic inflammation, ectopic lipid deposition, and insulin resistance. However, the molecular and functional characteristics of aged adipose progenitor cells (APCs), as well as effective strategies to rejuvenate their adipogenic potential, remain poorly understood. In this study, we found that aged mice exhibited a reduced frequency of APCs, increased inflammatory activity, and impaired adipogenic differentiation capacity. Strikingly, while quercetin exerted concentration-dependent effects on the vitality and function of APCs, only moderate doses specifically restored the adipogenic differentiation of aged APCs. Mechanistically, this rejuvenating effect was primarily mediated through the suppression of pro-inflammatory pathways. Together, our findings provide novel mechanistic insights into APCs aging in iWAT and identify quercetin as a promising rejuvenative agent for the treatment of adipose tissue dysfunction and related metabolic disorders in aging.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113027"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle ultrasonography texture in young, middle-aged, and older people and its association with functional performance: A machine learning-based study","authors":"Chaoran Liu ,&nbsp;Hui Shen ,&nbsp;Kai Zhang ,&nbsp;Xiumei Zhang ,&nbsp;Rui Wang ,&nbsp;Ninghua Wang","doi":"10.1016/j.exger.2026.113029","DOIUrl":"10.1016/j.exger.2026.113029","url":null,"abstract":"<div><h3>Background</h3><div>Skeletal muscle deterioration accelerates with age, leading to muscle atrophy and dysfunction. Musculoskeletal ultrasound as a nonradiative, inexpensive, and portable tool, has potential to evaluate age-related muscle changes. This study aims to detect age-related muscle features based on muscle texture analysis and machine learning approach, and to investigate muscle features that are related to function.</div></div><div><h3>Methods</h3><div>Healthy adults were recruited and divided into young, middle-aged, and older groups. 3 muscle architecture and 154 texture features were extracted from transverse (T) and longitudinal (L) ultrasonic images of muscle. Reliability analysis of all texture features was performed. Support vector machine recursive feature elimination (SVM-RFE) was utilized to identify age-related muscle parameters. Muscle features as contributors of muscle function measured by 4 performance tests were detected.</div></div><div><h3>Results</h3><div>113 participants were recruited. The inter-rater and test-retest reliability showed that 44 muscle ultrasonography texture features were reliable. Among them, 9 features including gray variance-T, 0°short run low gray-level emphasis-T, inertia-L, 0°short run emphasis-T, gray variance-L, gray average-L, 0°run percentage-T, 45°energy-T, and 0°low gray-level run emphasis-L could be used to classify young and older groups with the accuracy of 94.04%, and sensitivity of 93.33% by SVM-RFE. In the multivariate analysis, 3 texture features contributed to functional performance. Gradient mean variance has the highest predictive value.</div></div><div><h3>Conclusion</h3><div>Texture analysis combined with machine learning could provide non-invasive biomarkers to classify muscles of young and old individuals, and assist in function prediction.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113029"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence” [Exp. Gerontol. 186 (2024) 112359]","authors":"Ziqiang Fan,&nbsp;Yingdong Tong,&nbsp;Ziyue Yang,&nbsp;Shuai Wang,&nbsp;Tiantian Huang,&nbsp;Deying Yang,&nbsp;Qingyong Ni,&nbsp;Mingwang Zhang,&nbsp;Diyan Li,&nbsp;Mingyao Yang,&nbsp;Xiaolan Fan","doi":"10.1016/j.exger.2025.113021","DOIUrl":"10.1016/j.exger.2025.113021","url":null,"abstract":"","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113021"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and mating status modulate combined efficacy of α-lipoic acid and climbing to mitigate high-fat diet-induced oxidative stress in Drosophila melanogaster","authors":"Madappa Machamada Bheemaiah ,&nbsp;Debarati Chattopadhyay","doi":"10.1016/j.exger.2026.113045","DOIUrl":"10.1016/j.exger.2026.113045","url":null,"abstract":"<div><div>High-fat diet (HFD) intake is a potent inducer of oxidative stress, promoting metabolic dysfunction and accelerated ageing. Identifying interventions capable of mitigating this persistent redox burden is therefore essential. This study investigated the combined efficacy of α-lipoic acid (LA) supplementation and a daily climbing regimen in counteracting HFD-induced oxidative stress across different life stages and mating statuses in <em>Drosophila melanogaster</em>. Flies were maintained on an HFD and subjected to LA (2 mM or 2.5 mM), climbing exercise, or their combination during early, mid, or late life. Oxidative stress resistance was evaluated using hydrogen peroxide challenge assays, and peroxide accumulation was quantified via the FOX method. Combined LA and climbing treatment significantly enhanced stress resistance and reduced peroxide levels in early- and mid-life flies, outperforming either intervention alone. This benefit was most pronounced in unmated flies, indicating that physiological costs associated with mating diminish adaptive responsiveness. Notably, while LA alone reduced fecundity, its combination with climbing restored reproductive output, suggesting exercise-mediated alleviation of resource-allocation trade-offs. In late-life groups, the interventions produced only modest biochemical improvements without corresponding lifespan extension, highlighting age-related loss of physiological plasticity and the limited reversibility of cumulative oxidative damage. Overall, the findings demonstrated that integrating antioxidant supplementation with hormetic exercise elicited superior protection against HFD-induced oxidative stress, but the magnitude of benefit depended strongly on age and reproductive status. These results underscore the importance of early, multifaceted interventions to maintain redox balance and physiological resilience.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"214 ","pages":"Article 113045"},"PeriodicalIF":4.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}