镁耗尽评分与美国老年人虚弱患病率和死亡率的关系：1999-2018年NHANES的证据

IF 3.9

Experimental gerontology Pub Date : 2025-04-16 DOI:10.1016/j.exger.2025.112757

Haifeng Jiang , Wei Tao , Ting Jia , Weiwei Liu

{"title":"镁耗尽评分与美国老年人虚弱患病率和死亡率的关系：1999-2018年NHANES的证据","authors":"Haifeng Jiang , Wei Tao , Ting Jia , Weiwei Liu","doi":"10.1016/j.exger.2025.112757","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the associations between magnesium depletion score (MDS) and frailty prevalence, as well as its prognostic significance for all-cause and cardiovascular mortality among US older adults with frailty.</div></div><div><h3>Methods</h3><div>We analyzed data from older adults participating in the 1999–2018 National Health and Nutrition Examination Survey. The primary exposure was MDS, and the main outcomes were prevalence of frailty as defined by the 49-item accumulation-deficit model and all-cause or cardiovascular mortality in frail participants. The associations between MDS and frailty prevalence or mortality were analyzed using multivariable-adjusted logistic regression and Cox proportional hazards models, respectively.</div></div><div><h3>Results</h3><div>Overall, 13,551 participants (mean age 71.31 years, 45.46 % men, 4464 with frailty) were included. Compared with the MDS = 0 group, the multivariable-adjusted odds ratio and 95 % confidence interval (CI) for frailty were 1.144 (0.899–1.456), 1.702 (1.327–2.183), and 2.661 (2.038–3.475) for the MDS = 1, MDS = 2, and MDS ≥ 3 groups, respectively. A total of 2195 (791 cardiovascular-related) deaths occurred during a median follow-up of 70 months. Compared with the MDS = 0 group, the hazard ratios and 95 % CIs for the MDS = 1, MDS = 2, and MDS ≥ 3 groups were 1.509 (1.146–1.986), 1.988 (1.515–2.611), and 2.751 (2.125–3.562), respectively, for all-cause mortality, and 1.376 (0.843–2.246), 1.933 (1.183–3.160), and 2.872 (1.817–4.541), respectively for cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>A higher MDS is related to a higher prevalence of frailty and increased risk of all-cause and cardiovascular mortality in US older adults.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112757"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Magnesium depletion score in relation to frailty prevalence and mortality in US older adults: Evidence from 1999–2018 NHANES\",\"authors\":\"Haifeng Jiang , Wei Tao , Ting Jia , Weiwei Liu\",\"doi\":\"10.1016/j.exger.2025.112757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This study aimed to explore the associations between magnesium depletion score (MDS) and frailty prevalence, as well as its prognostic significance for all-cause and cardiovascular mortality among US older adults with frailty.</div></div><div><h3>Methods</h3><div>We analyzed data from older adults participating in the 1999–2018 National Health and Nutrition Examination Survey. The primary exposure was MDS, and the main outcomes were prevalence of frailty as defined by the 49-item accumulation-deficit model and all-cause or cardiovascular mortality in frail participants. The associations between MDS and frailty prevalence or mortality were analyzed using multivariable-adjusted logistic regression and Cox proportional hazards models, respectively.</div></div><div><h3>Results</h3><div>Overall, 13,551 participants (mean age 71.31 years, 45.46 % men, 4464 with frailty) were included. Compared with the MDS = 0 group, the multivariable-adjusted odds ratio and 95 % confidence interval (CI) for frailty were 1.144 (0.899–1.456), 1.702 (1.327–2.183), and 2.661 (2.038–3.475) for the MDS = 1, MDS = 2, and MDS ≥ 3 groups, respectively. A total of 2195 (791 cardiovascular-related) deaths occurred during a median follow-up of 70 months. Compared with the MDS = 0 group, the hazard ratios and 95 % CIs for the MDS = 1, MDS = 2, and MDS ≥ 3 groups were 1.509 (1.146–1.986), 1.988 (1.515–2.611), and 2.751 (2.125–3.562), respectively, for all-cause mortality, and 1.376 (0.843–2.246), 1.933 (1.183–3.160), and 2.872 (1.817–4.541), respectively for cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>A higher MDS is related to a higher prevalence of frailty and increased risk of all-cause and cardiovascular mortality in US older adults.</div></div>\",\"PeriodicalId\":94003,\"journal\":{\"name\":\"Experimental gerontology\",\"volume\":\"205 \",\"pages\":\"Article 112757\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental gerontology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0531556525000865\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental gerontology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0531556525000865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的本研究旨在探讨镁耗尽评分（MDS）与虚弱患病率之间的关系，以及其对美国老年虚弱患者全因死亡率和心血管死亡率的预后意义。方法分析参与1999-2018年全国健康与营养调查的老年人数据。主要暴露是MDS，主要结果是虚弱的患病率（由49项累积缺陷模型定义）和虚弱参与者的全因或心血管死亡率。分别使用多变量调整logistic回归和Cox比例风险模型分析MDS与虚弱患病率或死亡率之间的关系。结果共纳入13551名参与者（平均年龄71.31岁，45.46%为男性，4464名体弱者）。与MDS = 0组相比，MDS = 1组、MDS = 2组和MDS≥3组的多变量校正优势比和95%可信区间（CI）分别为1.144（0.899 ~ 1.456）、1.702（1.327 ~ 2.183）和2.661（2.038 ~ 3.475）。在中位随访70个月期间，共发生2195例（791例心血管相关）死亡。与MDS = 0组相比，MDS = 1、MDS = 2和MDS≥3组的全因死亡率风险比和95% ci分别为1.509（1.146 ~ 1.986）、1.988（1.515 ~ 2.611）、2.751(2.125 ~ 3.562)，心血管死亡率分别为1.376（0.843 ~ 2.246）、1.933（1.183 ~ 3.160）、2.872（1.817 ~ 4.541）。结论在美国老年人中，较高的MDS与更高的虚弱患病率、全因死亡率和心血管死亡率风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Magnesium depletion score in relation to frailty prevalence and mortality in US older adults: Evidence from 1999–2018 NHANES

Objective

This study aimed to explore the associations between magnesium depletion score (MDS) and frailty prevalence, as well as its prognostic significance for all-cause and cardiovascular mortality among US older adults with frailty.

Methods

We analyzed data from older adults participating in the 1999–2018 National Health and Nutrition Examination Survey. The primary exposure was MDS, and the main outcomes were prevalence of frailty as defined by the 49-item accumulation-deficit model and all-cause or cardiovascular mortality in frail participants. The associations between MDS and frailty prevalence or mortality were analyzed using multivariable-adjusted logistic regression and Cox proportional hazards models, respectively.

Results

Overall, 13,551 participants (mean age 71.31 years, 45.46 % men, 4464 with frailty) were included. Compared with the MDS = 0 group, the multivariable-adjusted odds ratio and 95 % confidence interval (CI) for frailty were 1.144 (0.899–1.456), 1.702 (1.327–2.183), and 2.661 (2.038–3.475) for the MDS = 1, MDS = 2, and MDS ≥ 3 groups, respectively. A total of 2195 (791 cardiovascular-related) deaths occurred during a median follow-up of 70 months. Compared with the MDS = 0 group, the hazard ratios and 95 % CIs for the MDS = 1, MDS = 2, and MDS ≥ 3 groups were 1.509 (1.146–1.986), 1.988 (1.515–2.611), and 2.751 (2.125–3.562), respectively, for all-cause mortality, and 1.376 (0.843–2.246), 1.933 (1.183–3.160), and 2.872 (1.817–4.541), respectively for cardiovascular mortality.