Stephen J. Carter , Tyler H. Blechschmid , Emily B. Long , Tenzin Yangchen , Marissa N. Baranauskas , Chad C. Wiggins , John S. Raglin , Andrew R. Coggan
{"title":"绝经后妇女肺活量和步行净量与疲劳和情绪障碍相关","authors":"Stephen J. Carter , Tyler H. Blechschmid , Emily B. Long , Tenzin Yangchen , Marissa N. Baranauskas , Chad C. Wiggins , John S. Raglin , Andrew R. Coggan","doi":"10.1016/j.exger.2025.112764","DOIUrl":null,"url":null,"abstract":"<div><div>Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m<sup>2</sup>; <em>n</em> = 14) or older (≥65 y; 81.8 ± 10.4 kg/m<sup>2</sup>; <em>n</em> = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O<sub>2peak</sub>). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O<sub>2</sub>). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O<sub>2</sub>. However, older women had lower aerobic capacity (<em>p</em> = 0.002, <em>ES</em> = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (<em>p</em> = 0.042, <em>ES</em> = 0.41). Among all participants, and independent of V̇O<sub>2peak</sub>, MRT correlated with average daily fatigue (<em>r</em> = 0.500, <em>p</em> = 0.015), fatigue interference (<em>r</em> = 0.421, <em>p</em> = 0.046), and POMS total mood disturbance (<em>r</em><sub><em>s</em></sub> = 0.437, <em>p</em> = 0.037). Regression modeling revealed MRT and walking net V̇O<sub>2</sub> jointly explained 55 % (<em>R</em> = 0.744, <em>p</em> < 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O<sub>2</sub> may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"205 ","pages":"Article 112764"},"PeriodicalIF":4.3000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women\",\"authors\":\"Stephen J. Carter , Tyler H. Blechschmid , Emily B. Long , Tenzin Yangchen , Marissa N. Baranauskas , Chad C. Wiggins , John S. Raglin , Andrew R. Coggan\",\"doi\":\"10.1016/j.exger.2025.112764\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m<sup>2</sup>; <em>n</em> = 14) or older (≥65 y; 81.8 ± 10.4 kg/m<sup>2</sup>; <em>n</em> = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O<sub>2peak</sub>). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O<sub>2</sub>). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O<sub>2</sub>. However, older women had lower aerobic capacity (<em>p</em> = 0.002, <em>ES</em> = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (<em>p</em> = 0.042, <em>ES</em> = 0.41). Among all participants, and independent of V̇O<sub>2peak</sub>, MRT correlated with average daily fatigue (<em>r</em> = 0.500, <em>p</em> = 0.015), fatigue interference (<em>r</em> = 0.421, <em>p</em> = 0.046), and POMS total mood disturbance (<em>r</em><sub><em>s</em></sub> = 0.437, <em>p</em> = 0.037). Regression modeling revealed MRT and walking net V̇O<sub>2</sub> jointly explained 55 % (<em>R</em> = 0.744, <em>p</em> < 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O<sub>2</sub> may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.</div></div>\",\"PeriodicalId\":94003,\"journal\":{\"name\":\"Experimental gerontology\",\"volume\":\"205 \",\"pages\":\"Article 112764\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental gerontology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0531556525000932\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental gerontology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0531556525000932","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
绝经后妇女经常感到疲劳和情绪紊乱,这两种情况都会影响生活质量。由于更好的身体功能有助于心理社会健康,我们假设步行时的急性心肺反应可能揭示了与疲劳和情绪障碍相关的重要因素。在这项横断面研究中,年龄在55-75岁之间体重指数(BMI)相似的女性被分为中年(55-65岁;83.4±8.4 kg/m2;N = 14)或以上(≥65岁;81.8±10.4 kg/m2;N = 11)组。6分钟步行试验用于估计峰值有氧能力(vo2峰值)。结合间接量热法的跑步机任务测量了平均反应时间(MRT)——代表达到稳态净摄氧量(vo2) 63%的持续时间。用疲劳症状量表测量平均每日疲劳和疲劳干扰。一般情绪障碍采用心境状态量表(POMS)进行测量。在疲劳评分、MRT或步行净V / O2方面没有发现年龄组差异。然而,老年妇女的有氧能力较低(p = 0.002, ES = 1.39),在POMS抑郁-抑郁亚量表中出现更大的紊乱(p = 0.042, ES = 0.41)。在所有被试中,MRT与平均每日疲劳(r = 0.500, p = 0.015)、疲劳干扰(r = 0.421, p = 0.046)和POMS总情绪障碍(rs = 0.437, p = 0.037)相关,且与vo2峰值无关。回归模型显示,MRT和步行净V (O2)共同解释了55% (R = 0.744, p <;平均每日疲劳的方差为0.001)。综上所述,MRT和步行净V (O2)可能是缓解绝经后妇女疲劳和情绪障碍的重要干预点。
Pulmonary V̇O2 on-kinetics and walking net V̇O2 associate with fatigue and mood disturbance in postmenopausal women
Postmenopausal women often experience fatigue and mood disturbance both of which interfere with quality-of-life. Since greater physical function aids psychosocial well-being, we hypothesized the acute cardiopulmonary responses during walking may reveal important factors linked to fatigue and mood disturbance. In this cross-sectional study, women of similar body mass index (BMI) aged 55-75 y were dichotomized to mid-life (55-65 y; 83.4 ± 8.4 kg/m2; n = 14) or older (≥65 y; 81.8 ± 10.4 kg/m2; n = 11) groups. A 6-minute walk test was used to estimate peak aerobic capacity (V̇O2peak). A treadmill task coupled with indirect calorimetry measured mean response time (MRT) – representing the duration to reach 63 % of steady-state net oxygen uptake (V̇O2). Average daily fatigue and fatigue interference were measured with the Fatigue Symptom Inventory. General mood disturbance was measured with the Profile of Mood States (POMS) questionnaire. Age-group differences were not detected in fatigue ratings, MRT, or walking net V̇O2. However, older women had lower aerobic capacity (p = 0.002, ES = 1.39) and greater disturbance in the POMS Depression-Dejection subscale (p = 0.042, ES = 0.41). Among all participants, and independent of V̇O2peak, MRT correlated with average daily fatigue (r = 0.500, p = 0.015), fatigue interference (r = 0.421, p = 0.046), and POMS total mood disturbance (rs = 0.437, p = 0.037). Regression modeling revealed MRT and walking net V̇O2 jointly explained 55 % (R = 0.744, p < 0.001) of the variance in average daily fatigue. In conclusion, MRT and walking net V̇O2 may serve as important points of intervention to alleviate fatigue and mood disturbance in postmenopausal women.