Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test

IF 4.3

Experimental gerontology Pub Date : 2025-04-30 DOI:10.1016/j.exger.2025.112767

Daniel Jiménez-Lupión , Ignacio Chirosa-Ríos , Rodrigo Lizama-Pérez , Luis Chirosa-Ríos , Daniel Jerez-Mayorga

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Abstract

Muscle power is a better indicator of musculoskeletal health and functional capacity than muscle strength. The Load-Velocity (L-V) relationship provides a method for assessing muscle function during dynamic multi-joint movements, making it valuable for identifying age-related neuromuscular decline. This study aimed to examine the relationship between variables derived from the L-V relationship (L₀, V₀, and A_line) obtained during the loaded sit-to-stand test and various muscle performance indices, including knee extension peak force (KEPF) and various muscle quality indices (MQI).

A total of 113 participants (49 middle-aged adults and 64 older adults; age = 61 ± 9.92 years) performed the loaded 5-Sit-To-Stand using Functional Electromechanical Dynamometry. L-V variables were calculated, and their relationships with indicators of muscle performance and quality were analyzed. The impact of age on these variables was also evaluated. The results showed a high positive correlation between A_line and KEPF, MQI_Equation1, MQI_Equation2 and MQI_Equation3 (rs = 0.56–0.59, p ≤0.001–0.01), and between V₀ and KEFP (rs = 0.51, p < 0.001). Older adults exhibited significantly lower L₀ compared to middle-aged adults (76.86 ± 29.74 kg vs. 94.62 ± 35.69 kg, p = 0.007), as well as lower V₀ (0.92 ± 0.28 m·s⁻¹ vs. 1.22 ± 0.19 m·s⁻¹, p < 0.001) and A_line values (35.39 ± 18.95 kg·m·s⁻¹ vs. 57.75 ± 23.84 kg·m·s⁻¹, p < 0.001). These findings suggest that L-V variables are valuable indicators for assessing muscle function deterioration and guiding training interventions, providing a more comprehensive and sensitive assessment of muscle quality and functional status in aging populations.

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老年人群肌肉功能退化的评估：从负重坐立测试中负载-速度关系的见解

肌肉力量比肌肉力量更能反映肌肉骨骼健康和功能能力。负载-速度（L-V）关系提供了一种在动态多关节运动中评估肌肉功能的方法，使其对识别与年龄相关的神经肌肉衰退有价值。本研究旨在检验负重坐立试验中获得的L-V关系（L0、V0和Aline）变量与各种肌肉性能指标(包括膝关节伸展峰值力（KEPF）和各种肌肉质量指标（MQI）之间的关系。共有113名参与者(49名中年人和64名老年人；年龄= 61±9.92岁)，采用功能机电测功仪进行负重5坐立试验。计算L-V变量，并分析其与肌肉性能和质量指标的关系。年龄对这些变量的影响也进行了评估。结果表明，Aline与KEPF、MQIEquation1、MQIEquation2、MQIEquation3呈正相关（rs = 0.56 ~ 0.59, p≤0.001 ~ 0.01），V0与KEFP呈正相关(rs = 0.51, p <；0.001)。老年人L0显著低于中年人（76.86±29.74 kg vs. 94.62±35.69 kg, p = 0.007）， V0显著低于中年人(0.92±0.28 m·s−1 vs. 1.22±0.19 m·s−1,p <；0.001)和艾琳值(35.39±18.95公斤·m·s−1和57.75±23.84公斤·m·s−1,p & lt;0.001)。这些发现表明，L-V变量是评估肌肉功能退化和指导训练干预的有价值的指标，为老年人肌肉质量和功能状态提供了更全面、更敏感的评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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